Primary Site >> Liver Cancer

Gene >> FOXO1

Journal: Gastroenterology. 2009 Nov;137(5):1816-26.e1-10.
Title: SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis.
Author: Calvisi, Diego F|Ladu, Sara|Pinna, Federico|Frau, Maddalena|Tomasi, Maria L|Sini, Marcella|Simile, Maria M|Bonelli, Piero|Muroni, Maria R|Seddaiu, Maria A|Lim, Dae-Sik|Feo, Francesco|Pascale, Rosa M
PMID: 19686743
Journal: Biochem Biophys Res Commun. 2009 Sep 4;386(4):757-61.
Title: Forkhead transcription factor FoxO1 inhibits insulin- and transforming growth factor-beta-stimulated plasminogen activator inhibitor-1 expression.
Author: Jung, Yun-A|Lee, Kyeong-Min|Kim, Mi-Kyung|Jung, Gwon-Soo|Seo, Ye-Jin|Kim, Hye-Soon|Cho, Ho-Chan|Lee, Ki-Up|Park, Keun-Gyu|Lee, In-Kyu
PMID: 19563779
Journal: Int J Cancer. 2010 Oct 1;127(7):1706-17.
Title: Muscle atrophy in experimental cancer cachexia: is the IGF-1 signaling pathway involved?
Author: Penna, Fabio|Bonetto, Andrea|Muscaritoli, Maurizio|Costamagna, Domiziana|Minero, Valerio Giacomo|Bonelli, Gabriella|Rossi Fanelli, Filippo|Baccino, Francesco Maria|Costelli, Paola
PMID: 20039316
Journal: Biochem Biophys Res Commun. 2011 Jan 28;404(4):963-7.
Title: FOXO1 stimulates ceruloplasmin promoter activity in human hepatoma cells treated with IL-6.
Author: Sidhu, Alpa|Miller, Patrick J|Hollenbach, Andrew D
PMID: 21185807
Journal: Eur Rev Med Pharmacol Sci. 2012 Aug;16(8):995-1000.
Title: From cirrhosis to hepatocellular carcinoma in HCV-infected patients: genes involved in tumor progression.
Author: Wang, Y|Li, J|Chen, J|Liu, L|Peng, Z|Ding, J|Ding, K
PMID: 22913147
Journal: Oncol Rep. 2013 Feb;29(2):653-61.
Title: Inhibition of miR-96 expression reduces cell proliferation and clonogenicity of HepG2 hepatoma cells.
Author: Xu, Dong|He, Xingxing|Chang, Ying|Xu, Chuanrui|Jiang, Xiang|Sun, Shuzhen|Lin, Jusheng
PMID: 23151657
Journal: Cell Cycle. 2013 Jan 1;12(1):67-75.
Title: Depletion of Aurora A leads to upregulation of FoxO1 to induce cell cycle arrest in hepatocellular carcinoma cells.
Author: Lee, Sun-Young|Lee, Gong Rak|Woo, Dong-Hyuk|Park, Neung Hwa|Cha, Hee Jeong|Moon, Yong-Hwan|Han, In-Seob
PMID: 23255113
Journal: BMC Cancer. 2013 Oct 10;13:468.
Title: FOXO/TXNIP pathway is involved in the suppression of hepatocellular carcinoma growth by glutamate antagonist MK-801.
Author: Yamaguchi, Fuminori|Hirata, Yuko|Akram, Hossain|Kamitori, Kazuyo|Dong, Youyi|Sui, Li|Tokuda, Masaaki
PMID: 24112473
Journal: BMC Cancer. 2014 Dec 3;14:909.
Title: MicroRNA-1269 promotes proliferation in human hepatocellular carcinoma via downregulation of FOXO1.
Author: Yang, Xue-Wei|Shen, Guan-Zhu|Cao, Liang-Qi|Jiang, Xiao-Feng|Peng, He-Ping|Shen, Gang|Chen, De|Xue, Ping
PMID: 25472505
Journal: J Transl Med. 2014 Aug 21;12:230.
Title: Viral expression and molecular profiling in liver tissue versus microdissected hepatocytes in hepatitis B virus-associated hepatocellular carcinoma.
Author: Melis, Marta|Diaz, Giacomo|Kleiner, David E|Zamboni, Fausto|Kabat, Juraj|Lai, Jinping|Mogavero, Giulia|Tice, Ashley|Engle, Ronald E|Becker, Steven|Brown, Charles R|Hanson, Jeffrey C|Rodriguez-Canales, Jaime|Emmert-Buck, Michael|Govindarajan, Sugantha|Kew,
PMID: 25141867
Journal: J Biol Chem. 2014 Sep 5;289(36):24759-70.
Title: GSK3 protein positively regulates type I insulin-like growth factor receptor through forkhead transcription factors FOXO1/3/4.
Author: Huo, Xiaodong|Liu, Shu|Shao, Ting|Hua, Hui|Kong, Qingbin|Wang, Jiao|Luo, Ting|Jiang, Yangfu
PMID: 25053419
Journal: Biochem Biophys Res Commun. 2014 Apr 18;446(4):1255-60.
Title: MicroRNA-145 suppresses hepatocellular carcinoma by targeting IRS1 and its downstream Akt signaling.
Author: Wang, Yelin|Hu, Chen|Cheng, Jun|Chen, Binquan|Ke, Qinghong|Lv, Zhen|Wu, Jian|Zhou, Yanfeng
PMID: 24690171
Journal: Cell Signal. 2014 Jul;26(7):1456-65.
Title: Galpha12gep oncogene inhibits FOXO1 in hepatocellular carcinoma as a consequence of miR-135b and miR-194 dysregulation.
Author: Jung, Hye Sun|Seo, Yu-Ri|Yang, Yoon Mee|Koo, Ja Hyun|An, Jihyun|Lee, Seung Jin|Kim, Kang Mo|Kim, Sang Geon
PMID: 24631529
Journal: J Virol. 2014 Apr;88(8):4195-203.
Title: Forkhead box transcription factor regulation and lipid accumulation by hepatitis C virus.
Author: Bose, Sandip K|Kim, Hangeun|Meyer, Keith|Wolins, Nathan|Davidson, Nicholas O|Ray, Ranjit
PMID: 24478438
Journal: J Biol Chem. 2015 Mar 13;290(11):7259-68.
Title: Insulin regulates retinol dehydrogenase expression and all-trans-retinoic acid biosynthesis through FoxO1.
Author: Obrochta, Kristin M|Krois, Charles R|Campos, Benito|Napoli, Joseph L
PMID: 25627686
Journal: PLoS One. 2015 Mar 4;10(3):e0119210.
Title: Polymorphisms in microRNA target sites of forkhead box O genes are associated with hepatocellular carcinoma.
Author: Tan, Chao|Liu, Shun|Tan, Shengkui|Zeng, Xiaoyun|Yu, Hongping|Li, Anhua|Bei, Chunhua|Qiu, Xiaoqiang
PMID: 25739100
Journal: Cancer Lett. 2015 Jun 28;362(1):97-105.
Title: Wnt/beta-Catenin activates MiR-183/96/182 expression in hepatocellular carcinoma that promotes cell invasion.
Author: Leung, Wilson K C|He, Mian|Chan, Anthony W H|Law, Priscilla T Y|Wong, Nathalie
PMID: 25813403
Journal: Oncotarget. 2015 Mar 20;6(8):6359-72.
Title: MicroRNA-3127 promotes cell proliferation and tumorigenicity in hepatocellular carcinoma by disrupting of PI3K/AKT negative regulation.
Author: Jiang, Jianxin|Zhang, Yi|Guo, Yuting|Yu, Chao|Chen, Meiyuan|Li, Zhu|Tian, Se|Sun, Chengyi
PMID: 25849943
Journal: Onco Targets Ther. 2015 Apr 7;8:735-44.
Title: Adipose tissue-secreted miR-27a promotes liver cancer by targeting FOXO1 in obese individuals.
Author: Sun, Baozhen|Li, Jing|Shao, Dan|Pan, Yue|Chen, Yujing|Li, Suo|Yao, Xiaoxiao|Li, Hang|Liu, Weiwei|Zhang, Ming|Zhang, Xuewen|Chen, Li
PMID: 25897249
Journal: Clin Sci (Lond). 2015 Nov;129(10):839-50.
Title: Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes.
Author: Liu, Tong-Yan|Shi, Chang-Xiang|Gao, Run|Sun, Hai-Jian|Xiong, Xiao-Qing|Ding, Lei|Chen, Qi|Li, Yue-Hua|Wang, Jue-Jin|Kang, Yu-Ming|Zhu, Guo-Qing
PMID: 26201094
Journal: Uirusu. 2015;65(2):263-268.
Title: Hepatitis C virus-induced glucose metabolic disorder.
Author: Shoji, Ikuo|Deng, Lin|Matsui, Chieko|Hotta, Hak
PMID: 27760925
Journal: Cancer Cell Int. 2016 Aug 2;16:63.
Title: miRNA-135a promotes hepatocellular carcinoma cell migration and invasion by targeting forkhead box O1.
Author: Zeng, Yue-Bin|Liang, Xing-Hua|Zhang, Guang-Xian|Jiang, Nan|Zhang, Tong|Huang, Jian-Ying|Zhang, Lei|Zeng, Xian-Cheng
PMID: 27486383
Journal: Oncotarget. 2016 Nov 1;7(44):71309-71329.
Title: Restoring miR122 in human stem-like hepatocarcinoma cells, prompts tumor dormancy through Smad-independent TGF-beta pathway.
Author: Boix, Loreto|Lopez-Oliva, Juan Manuel|Rhodes, Ana Carolina|Bruix, Jordi
PMID: 27612430
Journal: Cancer Lett. 2016 Nov 28;382(2):147-156.
Title: The oncoprotein HBXIP suppresses gluconeogenesis through modulating PCK1 to enhance the growth of hepatoma cells.
Author: Shi, Hui|Fang, Runping|Li, Yinghui|Li, Leilei|Zhang, Weiying|Wang, Huawei|Chen, Fuquan|Zhang, Shuqin|Zhang, Xiaodong|Ye, Lihong
PMID: 27609066
Journal: Cell Death Dis. 2016 Aug 4;7(8):e2324.
Title: Chemotherapy resistance and metastasis-promoting effects of thyroid hormone in hepatocarcinoma cells are mediated by suppression of FoxO1 and Bim pathway.
Author: Chi, Hsiang-Cheng|Chen, Shen-Liang|Cheng, Yi-Hung|Lin, Tzu-Kang|Tsai, Chung-Ying|Tsai, Ming-Ming|Lin, Yang-Hsiang|Huang, Ya-Hui|Lin, Kwang-Huei
PMID: 27490929
Journal: Oncotarget. 2016 Jul 12;7(28):44161-44170.
Title: Aquaporin 9 inhibits hepatocellular carcinoma through up-regulating FOXO1 expression.
Author: Li, Chuan-Fei|Zhang, Wen-Guang|Liu, Min|Qiu, Lie-Wang|Chen, Xiao-Feng|Lv, Lin|Mei, Zhe-Chuan
PMID: 27329843
Journal: Oncotarget. 2016 Mar 22;7(12):14336-49.
Title: Zinc finger protein ZBTB20 is an independent prognostic marker and promotes tumor growth of human hepatocellular carcinoma by repressing FoxO1.
Author: Kan, Heping|Huang, Yuqi|Li, Xianghong|Liu, Dingli|Chen, Jianjia|Shu, Miaojiang
PMID: 26893361
Journal: Sci Rep. 2016 Feb 16;6:21260.
Title: Interleukin-6-stimulated progranulin expression contributes to the malignancy of hepatocellular carcinoma cells by activating mTOR signaling.
Author: Liu, Feng|Zhang, Wen|Yang, Fusheng|Feng, Tingting|Zhou, Meng|Yu, Yuan|Yu, Xiuping|Zhao, Weiming|Yi, Fan|Tang, Wei|Lu, Yi
PMID: 26879559
Journal: Oncol Rep. 2016 Feb;35(2):625-38.
Title: Protein-protein interactions among signaling pathways may become new therapeutic targets in liver cancer (Review).
Author: Zhang, Xiao|Wang, Yulan|Wang, Jiayi|Sun, Fenyong
PMID: 26717966
Journal: Toxicol Appl Pharmacol. 2016 Jan 15;291:70-83.
Title: Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells.
Author: Shukla, Shatrunajay|Sharma, Ankita|Pandey, Vivek Kumar|Raisuddin, Sheikh|Kakkar, Poonam
PMID: 26712469
Journal: Mol Med Rep. 2016 Jun;13(6):5223-9.
Title: HCV core protein-induced upregulation of microRNA-196a promotes aberrant proliferation in hepatocellular carcinoma by targeting FOXO1.
Author: Xu, Hao|Li, Guangming|Yue, Zhanyi|Li, Chengzhong
PMID: 27108614
Journal: Oncol Rep. 2017 Oct;38(4):2148-2154.
Title: Downregulation of microRNA-196a inhibits human liver cancer cell proliferation and invasion by targeting FOXO1.
Author: Yang, Liu|Peng, Fei|Qin, Jian|Zhou, Henghua|Wang, Bing
PMID: 28791406
Journal: J Biol Chem. 2017 Nov 24;292(47):19146-19159.
Title: NK3 homeobox 1 (NKX3.1) up-regulates forkhead box O1 expression in hepatocellular carcinoma and thereby suppresses tumor proliferation and invasion.
Author: Jiang, Jingyi|Liu, Zheng|Ge, Chao|Chen, Cong|Zhao, Fangyu|Li, Hong|Chen, Taoyang|Yao, Ming|Li, Jinjun
PMID: 28972178
Journal: Toxicol Sci. 2017 Sep 1;159(1):25-41.
Title: Sex-Differential Responses of Tumor Promotion-Associated Genes and Dysregulation of Novel Long Noncoding RNAs in Constitutive Androstane Receptor-Activated Mouse Liver.
Author: Lodato, Nicholas J|Melia, Tisha|Rampersaud, Andy|Waxman, David J
PMID: 28903501
Journal: DNA Cell Biol. 2017 Oct;36(10):813-821.
Title: Trifluoperazine Activates FOXO1-Related Signals to Inhibit Tumor Growth in Hepatocellular Carcinoma.
Author: Jiang, Jingwen|Huang, Zhongxi|Chen, Xuewu|Luo, Rongcheng|Cai, Hongbin|Wang, Hairu|Zhang, Hui|Sun, Tao|Zhang, Yunfang
PMID: 28876084
Journal: Evid Based Complement Alternat Med. 2017;2017:4063865.
Title: Curcumin Induces p53-Null Hepatoma Cell Line Hep3B Apoptosis through the AKT-PTEN-FOXO4 Pathway.
Author: Liou, An-Ting|Chen, Mei-Fang|Yang, Chu-Wen
PMID: 28769986
Journal: Biochem Biophys Res Commun. 2017 May 20;487(1):167-172.
Title: miR-101 suppresses HBV replication and expression by targeting FOXO1 in hepatoma carcinoma cell lines.
Author: Wang, Yanjing|Tian, Hui
PMID: 28400278
Journal: World J Surg Oncol. 2017 Mar 16;15(1):63.
Title: Identification and interaction analysis of key genes and microRNAs in hepatocellular carcinoma by bioinformatics analysis.
Author: Mou, Tong|Zhu, Di|Wei, Xufu|Li, Tingting|Zheng, Daofeng|Pu, Junliang|Guo, Zhen|Wu, Zhongjun
PMID: 28302149
Journal: Oncol Res. 2017 Jan 2;25(1):65-73.
Title: MicroRNA-142-5p Overexpression Inhibits Cell Growth and Induces Apoptosis by Regulating FOXO in Hepatocellular Carcinoma Cells.
Author: Lou, Kexin|Chen, Ning|Li, Zhihong|Zhang, Bei|Wang, Xiuli|Chen, Ye|Xu, Haining|Wang, Dongwei|Wang, Hao
PMID: 28081734
Journal: Oncotarget. 2017 Jan 3;8(1):1703-1713.
Title: FOXO1 inhibits the invasion and metastasis of hepatocellular carcinoma by reversing ZEB2-induced epithelial-mesenchymal transition.
Author: Dong, Tianxiu|Zhang, Yu|Chen, Yaodong|Liu, Pengfei|An, Tingting|Zhang, Jiuwei|Yang, Haichao|Zhu, Wenjing|Yang, Xiuhua
PMID: 27924058
Journal: Sci Rep. 2018 Oct 29;8(1):15950.
Title: Molecular and Metabolic Markers of Fructose Induced Hepatic Insulin Resistance in Developing and Adult Rats are Distinct and Aegle marmelos is an Effective Modulator.
Author: Nair, Jayachandran|Velpandian, Thirumurthy|Das, Ujjalkumar Subhash|Sharma, Prateek|Nag, Tapas|Mathur, Sandeep R|Mathur, Rajani
PMID: 30374065
Journal: Oncol Rep. 2018 Sep 21.
Title: Upregulation of microRNA300 induces the proliferation of liver cancer by downregulating transcription factor FOXO1.
Author: Chang, Yuanhong|Zhou, Cancan|Fan, Lin|Qiu, Guanglin|Wang, Guanghui|Wei, Guangbing|Chang, Xinming|Li, Xuqi
PMID: 30272296
Journal: J Transl Med. 2018 Aug 9;16(1):220.
Title: A circRNA-miRNA-mRNA network identification for exploring underlying pathogenesis and therapy strategy of hepatocellular carcinoma.
Author: Xiong, Dan-Dan|Dang, Yi-Wu|Lin, Peng|Wen, Dong-Yue|He, Rong-Quan|Luo, Dian-Zhong|Feng, Zhen-Bo|Chen, Gang
PMID: 30092792
Journal: Theranostics. 2018 Jun 13;8(14):3808-3823.
Title: Self-assembled dual fluorescence nanoparticles for CD44-targeted delivery of anti-miR-27a in liver cancer theranostics.
Author: Zheng, Xiao|Zhang, Fan|Zhao, Yawei|Zhang, Jing|Dawulieti, Jianati|Pan, Yue|Cui, Lianzhi|Sun, Madi|Shao, Dan|Li, Mingqiang|He, Kan|Zhang, Ming|Li, Jing|Chen, Li
PMID: 30083261
Journal: Exp Mol Pathol. 2018 Aug;105(1):144-149.
Title: Different roles of FAT10, FOXO1, and ADRA2A in hepatocellular carcinoma tumorigenesis in patients with alcoholic steatohepatitis (ASH) vs non-alcoholic steatohepatitis (NASH).
Author: Jia, Yue|French, Barbara|Tillman, Brittany|French, Samuel
PMID: 30009772
Journal: Neoplasma. 2018 Sep 19;65(5):701-707.
Title: Overexpression of EPS8L3 promotes cell proliferation by inhibiting the transactivity of FOXO1 in HCC.
Author: Zeng, C X|Tang, L Y|Xie, C Y|Li, F X|Zhao, J Y|Jiang, N|Tong, Z|Fu, S B|Wen, F J|Feng, W S
PMID: 29940761
Journal: Medicine (Baltimore). 2018 Jun;97(23):e10892.
Title: Systems analysis of key genes and pathways in the progression of hepatocellular carcinoma.
Author: Shang, Yu-Kui|Li, Fanni|Zhang, Yi|Liu, Ze-Kun|Wang, Zi-Ling|Bian, Huijie|Chen, Zhi-Nan
PMID: 29879025
Journal: Oncotarget. 2018 Jan 9;9(25):17368-17395.
Title: An autophagy-related gene expression signature for survival prediction in multiple cohorts of hepatocellular carcinoma patients.
Author: Lin, Peng|He, Rong-Quan|Dang, Yi-Wu|Wen, Dong-Yue|Ma, Jie|He, Yun|Chen, Gang|Yang, Hong
PMID: 29707114
Journal: Blood. 2018 Jun 14;131(24):2670-2681.
Title: Genetic landscape of hepatitis B virus-associated diffuse large B-cell lymphoma.
Author: Ren, Weicheng|Ye, Xiaofei|Su, Hong|Li, Wei|Liu, Dongbing|Pirmoradian, Mohammad|Wang, Xianhuo|Zhang, Bo|Zhang, Qiang|Chen, Longyun|Nie, Man|Liu, Yao|Meng, Bin|Huang, Huiqiang|Jiang, Wenqi|Zeng, Yixin|Li, Wenyu|Wu, Kui|Hou, Yong|Wiman, Klas G|Li, Zhiming|Zh
PMID: 29545328
Journal: Toxicol Lett. 2018 Jun 1;289:63-74.
Title: Inhibition of sirtuins 1 and 2 impairs cell survival and migration and modulates the expression of P-glycoprotein and MRP3 in hepatocellular carcinoma cell lines.
Author: Ceballos, Maria Paula|Decandido, Giulia|Quiroga, Ariel Dario|Comanzo, Carla Gabriela|Livore, Veronica Ines|Lorenzetti, Florencia|Lambertucci, Flavia|Chazarreta-Cifre, Lorena|Banchio, Claudia|Alvarez, Maria de Lujan|Mottino, Aldo Domingo|Carrillo, Maria Cr
PMID: 29545174
Journal: FEBS J. 2018 Apr;285(7):1326-1345.
Title: Sestrin2 facilitates glutamine-dependent transcription of PGC-1alpha and survival of liver cancer cells under glucose limitation.
Author: Kumar, Ashish|Giri, Sagnik|Shaha, Chandrima
PMID: 29436167
Journal: Mol Imaging Biol. 2018 Jun;20(3):388-397.
Title: Metformin Promotes 2-Deoxy-2-[(18)F]Fluoro-D-Glucose Uptake in Hepatocellular Carcinoma Cells Through FoxO1-Mediated Downregulation of Glucose-6-Phosphatase.
Author: Wang, Zhengjie|Kang, Fei|Gao, Yongheng|Liu, Yi|Xu, Xiaolong|Ma, Xiaowei|Ma, Wenhui|Yang, Weidong|Wang, Jing
PMID: 29256045
Journal: Oncol Rep. 2018 Feb;39(2):843-850.
Title: Survival pathway of cholangiocarcinoma via AKT/mTOR signaling to escape RAF/MEK/ERK pathway inhibition by sorafenib.
Author: Yokoi, Kenta|Kobayashi, Akira|Motoyama, Hiroaki|Kitazawa, Masato|Shimizu, Akira|Notake, Tsuyoshi|Yokoyama, Takahide|Matsumura, Tomio|Takeoka, Michiko|Miyagawa, Shin-Ichi
PMID: 29251327
Journal: Cancer Res. 2018 Feb 1;78(3):645-658.
Title: SIRT6 Is a Target of Regulation by UBE3A That Contributes to Liver Tumorigenesis in an ANXA2-Dependent Manner.
Author: Kohli, Saishruti|Bhardwaj, Abhishek|Kumari, Richa|Das, Sanjeev
PMID: 29217762