Primary Site >> Colorectal Cancer

Gene >> FLT3

Journal: Oncogene. 1994 Jul;9(7):1977-88.
Title: Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern.
Author: Levedakou, E N|He, M|Baptist, E W|Craven, R J|Cance, W G|Welcsh, P L|Simmons, A|Naylor, S L|Leach, R J|Lewis, T B
PMID: 8208544
Journal: Int J Cancer. 2000 Apr 15;86(2):238-43.
Title: FLT3 ligand gene expression and protein production in human colorectal cancer cell lines and clinical tumor specimens.
Author: Spagnoli, G C|Kloth, J|Terracciano, L|Trutmann, M|Chklovskaia, E|Remmel, E|Noppen, C|Zajac, P|Kocher, T|Heberer, M
PMID: 10738251
Journal: Int J Cancer. 2000 Jun 15;86(6):827-34.
Title: Flt3 ligand lessens the growth of tumors obtained after colon cancer cell injection in rats but does not restore tumor-suppressed dendritic cell function.
Author: Favre-Felix, N|Martin, M|Maraskovsky, E|Fromentin, A|Moutet, M|Solary, E|Martin, F|Bonnotte, B
PMID: 10842197
Journal: Oncogene. 2004 Feb 26;23(8):1618-26.
Title: Gene expression profiling of human colon xenograft tumors following treatment with SU11248, a multitargeted tyrosine kinase inhibitor.
Author: Morimoto, Alyssa M|Tan, Nguyen|West, Kristina|McArthur, Grant|Toner, Guy C|Manning, William C|Smolich, Beverly D|Cherrington, Julie M
PMID: 14985702
Journal: Clin Cancer Res. 2005 Aug 15;11(16):5827-32.
Title: Early antiangiogenic activity of SU11248 evaluated in vivo by dynamic contrast-enhanced magnetic resonance imaging in an experimental model of colon carcinoma.
Author: Marzola, Pasquina|Degrassi, Anna|Calderan, Laura|Farace, Paolo|Nicolato, Elena|Crescimanno, Caterina|Sandri, Marco|Giusti, Anna|Pesenti, Enrico|Terron, Andrea|Sbarbati, Andrea|Osculati, Francesco
PMID: 16115922
Journal: J Clin Oncol. 2007 Mar 1;25(7):884-96.
Title: Sunitinib: from rational design to clinical efficacy.
Author: Chow, Laura Q M|Eckhardt, S Gail
PMID: 17327610
Journal: Leukemia. 2007 Aug;21(8):1638-47.
Title: The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia.
Author: Mikesch, J-H|Steffen, B|Berdel, W E|Serve, H|Muller-Tidow, C
PMID: 17554387
Journal: Curr Med Chem. 2007;14(29):3122-38.
Title: Drug-mediated targeted disruption of multiple protein activities through functional inhibition of the Hsp90 chaperone complex.
Author: Stravopodis, Dimitrios J|Margaritis, Lukas H|Voutsinas, Gerassimos E
PMID: 18220746
Journal: Gerontology. 2010;56(3):303-9.
Title: Antiangiogenic drugs in oncology: a focus on drug safety and the elderly - a mini-review.
Author: Boehm, S|Rothermundt, C|Hess, D|Joerger, M
PMID: 19940466
Journal: Cancer Biol Ther. 2011 Oct 1;12(7):586-97. Epub 2011 Oct 1.
Title: Anticancer imidazoacridinone C-1311 inhibits hypoxia-inducible factor-1alpha (HIF-1alpha), vascular endothelial growth factor (VEGF) and angiogenesis.
Author: Paradziej-Lukowicz, Jolanta|Skwarska, Anna|Peszynska-Sularz, Grazyna|Brillowska-Dabrowska, Anna|Konopa, Jerzy
PMID: 21775820
Journal: PLoS One. 2011;6(12):e28841.
Title: Antitumor activity of sorafenib in human cancer cell lines with acquired resistance to EGFR and VEGFR tyrosine kinase inhibitors.
Author: Morgillo, Floriana|Martinelli, Erika|Troiani, Teresa|Orditura, Michele|De Vita, Ferdinando|Ciardiello, Fortunato
PMID: 22174910
Journal: Ann Hematol. 2012 Feb;91(2):173-81.
Title: The novel compound OSI-461 induces apoptosis and growth arrest in human acute myeloid leukemia cells.
Author: Singh, Raminder|Frobel, Julia|Cadeddu, Ron-Patrick|Bruns, Ingmar|Schroeder, Thomas|Brunnert, Daniela|Wilk, Christian Matthias|Zerbini, Luiz Fernando|Haas, Rainer|Czibere, Akos
PMID: 21717102
Journal: Int Immunopharmacol. 2012 Mar;12(3):481-6.
Title: Flt3 ligand enhances anti-tumor effects of antibody therapeutics.
Author: Maruyama, Kouji|Selmani, Zohair|Ishii, Hidee|Tai, Sachiko|Cheng, Jinyan|Akimoto, Shingo|Watanabe, Morihiro|Yamaguchi, Ken
PMID: 22245429
Journal: Invest New Drugs. 2012 Apr;30(2):518-23.
Title: Evaluation of a multi-kinase inhibitor KRC-108 as an anti-tumor agent in vitro and in vivo.
Author: Han, Sun-Young|Lee, Chong Ock|Ahn, Sung-Hoon|Lee, Mi-Ok|Kang, So-Young|Cha, Hyuk-Jin|Cho, Sung Yun|Ha, Jae Du|Ryu, Jae Wook|Jung, Heejung|Kim, Hyoung Rae|Koh, Jong Sung|Lee, Jongkook
PMID: 21080208
Journal: Mol Cancer Res. 2014 Jun;12(6):823-9.
Title: HD chromoendoscopy coupled with DNA mass spectrometry profiling identifies somatic mutations in microdissected human proximal aberrant crypt foci.
Author: Drew, David A|Devers, Thomas J|O'Brien, Michael J|Horelik, Nicole A|Levine, Joel|Rosenberg, Daniel W
PMID: 24651453
Journal: BMC Cancer. 2014 Jul 11;14:510.
Title: Vascular effects, efficacy and safety of nintedanib in patients with advanced, refractory colorectal cancer: a prospective phase I subanalysis.
Author: Mross, Klaus|Buchert, Martin|Frost, Annette|Medinger, Michael|Stopfer, Peter|Studeny, Matus|Kaiser, Rolf
PMID: 25012508
Journal: Case Rep Oncol. 2015 Feb 11;8(1):83-7.
Title: Clinical Response to Sorafenib in a Patient with Metastatic Colorectal Cancer and FLT3 Amplification.
Author: Moreira, Raphael Brandao|Peixoto, Renata D'Alpino|de Sousa Cruz, Marcelo Rocha
PMID: 25848357
Journal: Nat Med. 2015 Jul;21(7):795-801.
Title: Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients.
Author: Siravegna, Giulia|Mussolin, Benedetta|Buscarino, Michela|Corti, Giorgio|Cassingena, Andrea|Crisafulli, Giovanni|Ponzetti, Agostino|Cremolini, Chiara|Amatu, Alessio|Lauricella, Calogero|Lamba, Simona|Hobor, Sebastijan|Avallone, Antonio|Valtorta, Emanuele|R
PMID: 26030179
Journal: Oncotarget. 2015 Nov 17;6(36):38804-15.
Title: Association of the EGF-TM7 receptor CD97 expression with FLT3-ITD in acute myeloid leukemia.
Author: Wobus, Manja|Bornhauser, Martin|Jacobi, Angela|Krater, Martin|Otto, Oliver|Ortlepp, Claudia|Guck, Jochen|Ehninger, Gerhard|Thiede, Christian|Oelschlagel, Uta
PMID: 26462154
Journal: Mol Cell Proteomics. 2016 Feb;15(2):682-91.
Title: Quantitative Profiling of Protein Tyrosine Kinases in Human Cancer Cell Lines by Multiplexed Parallel Reaction Monitoring Assays.
Author: Kim, Hye-Jung|Lin, De|Lee, Hyoung-Joo|Li, Ming|Liebler, Daniel C
PMID: 26631510
Journal: Med Oncol. 2016 Oct;33(10):106.
Title: Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing.
Author: Jauhri, Mayank|Bhatnagar, Akanksha|Gupta, Satish|Shokeen, Yogender|Minhas, Sachin|Aggarwal, Shyam
PMID: 27568332
Journal: Tumour Biol. 2017 Jul;39(7):1010428317709638.
Title: Oncogene mutation profile predicts tumor regression and survival in locally advanced rectal cancer patients treated with preoperative chemoradiotherapy and radical surgery.
Author: Peng, Jianhong|Lin, Junzhong|Qiu, Miaozhen|Zhao, Yujie|Deng, Yuxiang|Shao, Jianyong|Ding, Peirong|Zhang, Huizhong|Wan, Desen|Lu, Zhenhai|Pan, Zhizhong
PMID: 28671043
Journal: Genes Chromosomes Cancer. 2017 Nov;56(11):769-787.
Title: The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer.
Author: Slattery, Martha L|Herrick, Jennifer S|Mullany, Lila E|Samowitz, Wade S|Sevens, John R|Sakoda, Lori|Wolff, Roger K
PMID: 28675510
Journal: Rom J Morphol Embryol. 2017;58(2):655-663.
Title: Morphology with immunohistochemical and genetic profiling of high-grade neuroendocrine carcinoma of colon - a case report with review of literature.
Author: Wincewicz, Andrzej|Kowalik, Artur|Zieba, Sebastian|Sulkowski, Stanislaw|Gozdz, Stanislaw
PMID: 28730258
Journal: Cancer Lett. 2018 Nov 1;436:28-37.
Title: PTEN deficiency confers colorectal cancer cell resistance to dual inhibitors of FLT3 and aurora kinase A.
Author: Liu, Yifan|Yang, Eun Ju|Zhang, Baoyuan|Miao, Zhengqiang|Wu, Changjie|Lyu, Junfang|Tan, Kaeling|Poon, Terence Chuen Wai|Shim, Joong Sup
PMID: 30118842