Primary Site >> Colorectal Cancer
Gene >> FLT3
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Ref: Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern. PMID: 8208544 |
Ref: FLT3 ligand gene expression and protein production in human colorectal cancer cell lines and clinical tumor specimens. PMID: 10738251 Ref: Flt3 ligand lessens the growth of tumors obtained after colon cancer cell injection in rats but does not restore tumor-suppressed dendritic cell function. PMID: 10842197 |
Ref: Gene expression profiling of human colon xenograft tumors following treatment with SU11248, a multitargeted tyrosine kinase inhibitor. PMID: 14985702 |
Ref: Early antiangiogenic activity of SU11248 evaluated in vivo by dynamic contrast-enhanced magnetic resonance imaging in an experimental model of colon carcinoma. PMID: 16115922 |
Ref: Sunitinib: from rational design to clinical efficacy. PMID: 17327610 Ref: The emerging role of Wnt signaling in the pathogenesis of acute myeloid leukemia. PMID: 17554387 Ref: Drug-mediated targeted disruption of multiple protein activities through functional inhibition of the Hsp90 chaperone complex. PMID: 18220746 |
Ref: Antiangiogenic drugs in oncology: a focus on drug safety and the elderly - a mini-review. PMID: 19940466 |
Ref: Anticancer imidazoacridinone C-1311 inhibits hypoxia-inducible factor-1alpha (HIF-1alpha), vascular endothelial growth factor (VEGF) and angiogenesis. PMID: 21775820 Ref: Antitumor activity of sorafenib in human cancer cell lines with acquired resistance to EGFR and VEGFR tyrosine kinase inhibitors. PMID: 22174910 |
Ref: Evaluation of a multi-kinase inhibitor KRC-108 as an anti-tumor agent in vitro and in vivo. PMID: 21080208 Ref: The novel compound OSI-461 induces apoptosis and growth arrest in human acute myeloid leukemia cells. PMID: 21717102 Ref: Flt3 ligand enhances anti-tumor effects of antibody therapeutics. PMID: 22245429 |
Ref: HD chromoendoscopy coupled with DNA mass spectrometry profiling identifies somatic mutations in microdissected human proximal aberrant crypt foci. PMID: 24651453 Ref: Vascular effects, efficacy and safety of nintedanib in patients with advanced, refractory colorectal cancer: a prospective phase I subanalysis. PMID: 25012508 |
Ref: Clinical Response to Sorafenib in a Patient with Metastatic Colorectal Cancer and FLT3 Amplification. PMID: 25848357 Ref: Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients. PMID: 26030179 Ref: Association of the EGF-TM7 receptor CD97 expression with FLT3-ITD in acute myeloid leukemia. PMID: 26462154 |
Ref: Quantitative Profiling of Protein Tyrosine Kinases in Human Cancer Cell Lines by Multiplexed Parallel Reaction Monitoring Assays. PMID: 26631510 Ref: Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing. PMID: 27568332 |
Ref: Oncogene mutation profile predicts tumor regression and survival in locally advanced rectal cancer patients treated with preoperative chemoradiotherapy and radical surgery. PMID: 28671043 Ref: The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer. PMID: 28675510 Ref: Morphology with immunohistochemical and genetic profiling of high-grade neuroendocrine carcinoma of colon - a case report with review of literature. PMID: 28730258 |
Ref: PTEN deficiency confers colorectal cancer cell resistance to dual inhibitors of FLT3 and aurora kinase A. PMID: 30118842 |