Primary Site >> Liver Cancer

Gene >> FASN

Journal: Oncol Res. 2005;16(3):119-28.
Title: Pu-erh tea supplementation suppresses fatty acid synthase expression in the rat liver through downregulating Akt and JNK signalings as demonstrated in human hepatoma HepG2 cells.
Author: Chiang, Chun-Te|Weng, Meng-Shih|Lin-Shiau, Shoei-Yn|Kuo, Kuan-Li|Tsai, Yao-Jen|Lin, Jen-Kun
PMID: 16925113
Journal: Exp Mol Pathol. 2006 Apr;80(2):109-18.
Title: Mallory body forming cells express the preneoplastic hepatocyte phenotype.
Author: Nan, Li|Bardag-Gorce, Fawzia|Wu, Yong|Li, Jun|French, Barbara A|French, Samuel W
PMID: 16413534
Journal: Cancer Biol Ther. 2006 Aug;5(8):978-85. Epub 2006 Aug 3.
Title: Growth arrest induced by C75, A fatty acid synthase inhibitor, was partially modulated by p38 MAPK but not by p53 in human hepatocellular carcinoma.
Author: Gao, Yan|Lin, Li-Ping|Zhu, Cai-Hua|Chen, Yi|Hou, Yong-Tai|Ding, Jian
PMID: 16855382
Journal: Zhonghua Yi Xue Za Zhi. 2008 Mar 25;88(12):848-52.
Title: [Activation of liver X receptor regulates fatty acid synthase expression in diabetic liver].
Author: Wang, Bing|Cheng, Li-Jing|Gao, Zheng-Nan|Zhang, Xiao-Yan|Huo, Ming|Zhang, Dong-Juan|Wu, Jing|Wei, Ming-Fen
PMID: 18756992
Journal: Biochem J. 2008 Dec 1;416(2):219-30.
Title: Hepatitis B virus X protein induces lipogenic transcription factor SREBP1 and fatty acid synthase through the activation of nuclear receptor LXRalpha.
Author: Kim, Kyeongjin|Kim, Kook Hwan|Kim, Hyeong Hoe|Cheong, Jaehun
PMID: 18782084
Journal: Hepatology. 2008 Nov;48(5):1396-403.
Title: Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and production.
Author: Yang, Wei|Hood, Brian L|Chadwick, Sara L|Liu, Shufeng|Watkins, Simon C|Luo, Guangxiang|Conrads, Thomas P|Wang, Tianyi
PMID: 18830996
Journal: Hepatology. 2009 Apr;49(4):1122-31.
Title: Liver X receptor mediates hepatitis B virus X protein-induced lipogenesis in hepatitis B virus-associated hepatocellular carcinoma.
Author: Na, Tae-Young|Shin, Young Kee|Roh, Kyung Jin|Kang, Shin-Ae|Hong, Il|Oh, Sae Jin|Seong, Je Kyung|Park, Cheol Keun|Choi, Yoon La|Lee, Mi-Ock
PMID: 19105208
Journal: J Environ Sci (China). 2009;21 Suppl 1:S131-4.
Title: Inhibitory effects of four plants flavonoids extracts on fatty acid synthase.
Author: Chen, Jun|Zhuang, Donghong|Cai, Weijia|Xu, Liyan|Li, Enmin|Wu, Yunying|Sugiyama, Kazuo
PMID: 25084411
Journal: Neoplasia. 2010 Feb;12(2):103-15.
Title: A mutant of hepatitis B virus X protein (HBxDelta127) promotes cell growth through a positive feedback loop involving 5-lipoxygenase and fatty acid synthase.
Author: Wang, Qi|Zhang, Weiying|Liu, Qiang|Zhang, Xuan|Lv, Na|Ye, Lihong|Zhang, Xiaodong
PMID: 20126469
Journal: Int J Oncol. 2010 Jun;36(6):1453-9.
Title: Identification of autoantibody against fatty acid synthase in hepatocellular carcinoma mouse model and its application to diagnosis of HCC.
Author: Heo, Chang-Kyu|Woo, Mi-Kyung|Yu, Dae-Yeul|Lee, Ju Yeon|Yoo, Jong Shin|Yoo, Hyang Sook|Ko, Jeong Heon|Kim, Jin-Man|Choi, Jong Young|Kim, In Gyu|Paik, Sang Gi|Cho, Eun-Wie
PMID: 20428769
Journal: Cancer Sci. 2010 Aug;101(8):1861-5.
Title: Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice.
Author: Murata, Soichiro|Yanagisawa, Kazuhiko|Fukunaga, Kiyoshi|Oda, Tatsuya|Kobayashi, Akihiko|Sasaki, Ryoko|Ohkohchi, Nobuhiro
PMID: 20491775
Journal: Lipids Health Dis. 2011 Jan 18;10:10.
Title: Polyunsaturated fatty acids reduce fatty acid synthase and hydroxy-methyl-glutaryl CoA-reductase gene expression and promote apoptosis in HepG2 cell line.
Author: Notarnicola, Maria|Messa, Caterina|Refolo, Maria G|Tutino, Valeria|Miccolis, Angelica|Caruso, Maria G
PMID: 21244676
Journal: Int J Cancer. 2012 Feb 1;130(3):497-508.
Title: Diet-induced obesity increases melanoma progression: involvement of Cav-1 and FASN.
Author: Pandey, Vimal|Vijayakumar, Maleppillil Vavachan|Ajay, Amrendra Kumar|Malvi, Parmanand|Bhat, Manoj Kumar
PMID: 21387314
Journal: Int J Mol Sci. 2012;13(8):9980-91.
Title: Combined phosphatase and tensin homolog (PTEN) loss and fatty acid synthase (FAS) overexpression worsens the prognosis of Chinese patients with hepatocellular carcinoma.
Author: Zhu, Xuehua|Qin, Xia|Fei, Maogui|Hou, Wenmin|Greshock, Joel|Bachman, Kurtis E|Wooster, Richard|Kang, Jiuhong|Qin, Crystal Ying
PMID: 22949843
Journal: J Virol. 2013 May;87(9):4994-5004.
Title: Hepatitis C virus replication is modulated by the interaction of nonstructural protein NS5B and fatty acid synthase.
Author: Huang, Jing-Tang|Tseng, Ching-Ping|Liao, Mei-Huei|Lu, Shao-Chun|Yeh, Wei-Zhou|Sakamoto, Naoya|Chen, Chuan-Mu|Cheng, Ju-Chien
PMID: 23427160
Journal: PLoS One. 2013 Apr 16;8(4):e61524.
Title: Inherent and acquired resistance to paclitaxel in hepatocellular carcinoma: molecular events involved.
Author: Meena, Avtar Singh|Sharma, Aanchal|Kumari, Ratna|Mohammad, Naoshad|Singh, Shivendra Vikram|Bhat, Manoj Kumar
PMID: 23613870
Journal: Genes Nutr. 2013 Jan;8(1):105-13.
Title: Dietary supplementation with methyl donors reduces fatty liver and modifies the fatty acid synthase DNA methylation profile in rats fed an obesogenic diet.
Author: Cordero, P|Gomez-Uriz, A M|Campion, J|Milagro, F I|Martinez, J A
PMID: 22648174
Journal: Target Oncol. 2014 Sep;9(3):279-86.
Title: Curcumin induces apoptosis of HepG2 cells via inhibiting fatty acid synthase.
Author: Fan, Huijin|Tian, Weixi|Ma, Xiaofeng
PMID: 23821378
Journal: Int J Obes (Lond). 2014 Sep;38(9):1172-9.
Title: Kefir improves fatty liver syndrome by inhibiting the lipogenesis pathway in leptin-deficient ob/ob knockout mice.
Author: Chen, H-L|Tung, Y-T|Tsai, C-L|Lai, C-W|Lai, Z-L|Tsai, H-C|Lin, Y-L|Wang, C-H|Chen, C-M
PMID: 24335764
Journal: J Virol. 2014 Apr;88(8):4195-203.
Title: Forkhead box transcription factor regulation and lipid accumulation by hepatitis C virus.
Author: Bose, Sandip K|Kim, Hangeun|Meyer, Keith|Wolins, Nathan|Davidson, Nicholas O|Ray, Ranjit
PMID: 24478438
Journal: Org Lett. 2014 Mar 7;16(5):1414-7.
Title: In situ proteome profiling of C75, a covalent bioactive compound with potential anticancer activities.
Author: Cheng, Xiamin|Li, Lin|Uttamchandani, Mahesh|Yao, Shao Q
PMID: 24552542
Journal: Int J Mol Sci. 2014 Mar 5;15(3):4019-30.
Title: The effect and mechanism of tamoxifen-induced hepatocyte steatosis in vitro.
Author: Zhao, Fei|Xie, Ping|Jiang, Jiali|Zhang, Lingqiang|An, Wei|Zhan, Yutao
PMID: 24603540
Journal: J Nutr. 2014 Jul;144(7):1009-15.
Title: Luteolin alleviates alcoholic liver disease induced by chronic and binge ethanol feeding in mice.
Author: Liu, Gaigai|Zhang, Yuxue|Liu, Chunchun|Xu, Daqian|Zhang, Rui|Cheng, Yuan|Pan, Yi|Huang, Cheng|Chen, Yan
PMID: 24828027
Journal: Oncol Lett. 2014 Aug;8(2):765-769.
Title: Quercetin induces HepG2 cell apoptosis by inhibiting fatty acid biosynthesis.
Author: Zhao, Peng|Mao, Jun-Min|Zhang, Shu-Yun|Zhou, Ze-Quan|Tan, Yang|Zhang, Yu
PMID: 25009654
Journal: Int J Oncol. 2014 Nov;45(5):2143-52.
Title: MicroRNA-449 suppresses proliferation of hepatoma cell lines through blockade lipid metabolic pathway related to SIRT1.
Author: Zhang, Hongyi|Feng, Zhiqiang|Huang, Rui|Xia, Zhenglin|Xiang, Guoan|Zhang, Jinqian
PMID: 25119660
Journal: Oncol Rep. 2014 Dec;32(6):2471-6.
Title: Expression and roles of fatty acid synthase in hepatocellular carcinoma.
Author: Hao, Qiwei|Li, Tao|Zhang, Xiong|Gao, Ping|Qiao, Peiyu|Li, Sheng|Geng, Zhimin
PMID: 25231933
Journal: J Hepatol. 2015 Dec;63(6):1378-89.
Title: CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARalpha pathways.
Author: Li, Jibin|Huang, Qichao|Long, Xiaoyu|Zhang, Jing|Huang, Xiaojun|Aa, Jiye|Yang, Hushan|Chen, Zhinan|Xing, Jinliang
PMID: 26282231
Journal: Sci Rep. 2015 Mar 26;5:9536.
Title: Genetic variants in de novo lipogenic pathway genes predict the prognosis of surgically-treated hepatocellular carcinoma.
Author: Jiang, Hequn|Dai, Jingyao|Huang, Xiaojun|Chen, Yibing|Qu, Ping|Li, Jibin|Yi, Cheng|Yang, Yefa|Zhang, Kejing|Huang, Qichao
PMID: 25826294
Journal: Asian Pac J Cancer Prev. 2015;16(3):1051-6.
Title: Polymorphisms in genes of the de novo lipogenesis pathway and overall survival of hepatocellular carcinoma patients undergoing transarterial chemoembolization.
Author: Wu, You-Sheng|Bao, Deng-Ke|Dai, Jing-Yao|Chen, Cheng|Zhang, Hong-Xin|Yang, YeFa|Xing, Jin-Liang|Huang, Xiao-Jun|Wan, Shao-Gui
PMID: 25735330
Journal: J Hepatol. 2016 Feb;64(2):333-341.
Title: Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans.
Author: Li, Lei|Pilo, Giulia M|Li, Xiaolei|Cigliano, Antonio|Latte, Gavinella|Che, Li|Joseph, Christy|Mela, Marta|Wang, Chunmei|Jiang, Lijie|Ribback, Silvia|Simile, Maria M|Pascale, Rosa M|Dombrowski, Frank|Evert, Matthias|Semenkovich, Clay F|Chen, Xin|Calvisi, D
PMID: 26476289
Journal: Mol Imaging Biol. 2016 Jun;18(3):360-7.
Title: [(11)C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice.
Author: Li, Lei|Che, Li|Wang, Chunmei|Blecha, Joseph E|Li, Xiaolei|VanBrocklin, Henry F|Calvisi, Diego F|Puchowicz, Michelle|Chen, Xin|Seo, Youngho
PMID: 26567114
Journal: Biochim Biophys Acta. 2016 Mar;1861(3):166-76.
Title: Improvement of mTORC1-driven overproduction of apoB-containing triacylglyceride-rich lipoproteins by short-chain fatty acids, 4-phenylbutyric acid and (R)-alpha-lipoic acid, in human hepatocellular carcinoma cells.
Author: Roberts, Joseph L|He, Bo|Erickson, Anjeza|Moreau, Regis
PMID: 26680362
Journal: Sci Rep. 2016 Feb 9;6:20484.
Title: Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice.
Author: Hu, Junjie|Che, Li|Li, Lei|Pilo, Maria G|Cigliano, Antonio|Ribback, Silvia|Li, Xiaolei|Latte, Gavinella|Mela, Marta|Evert, Matthias|Dombrowski, Frank|Zheng, Guohua|Chen, Xin|Calvisi, Diego F
PMID: 26857837
Journal: Hepatology. 2016 Jun;63(6):1900-13.
Title: Differential requirement for de novo lipogenesis in cholangiocarcinoma and hepatocellular carcinoma of mice and humans.
Author: Li, Lei|Che, Li|Tharp, Kevin M|Park, Hyo-Min|Pilo, Maria G|Cao, Dan|Cigliano, Antonio|Latte, Gavinella|Xu, Zhong|Ribback, Silvia|Dombrowski, Frank|Evert, Matthias|Gores, Gregory J|Stahl, Andreas|Calvisi, Diego F|Chen, Xin
PMID: 26910791
Journal: Mol Med Rep. 2016 Jun;13(6):4751-8.
Title: Artemisia capillaris formula inhibits hepatic steatosis via an miR122induced decrease in fatty acid synthase expression in vivo and in vitro.
Author: Liu, Liya|Zhao, Jinyan|Li, Ying|Wan, Yun|Lin, Jiumao|Shen, Aling|Xu, Wei|Li, Huang|Zhang, Yuchen|Xu, Jianfeng|Peng, Jun|Hong, Zhenfeng
PMID: 27081834
Journal: J Mol Biol. 2016 Aug 14;428(16):3295-3304.
Title: The Nutrient-Dependent O-GlcNAc Modification Controls the Expression of Liver Fatty Acid Synthase.
Author: Baldini, Steffi F|Wavelet, Cindy|Hainault, Isabelle|Guinez, Celine|Lefebvre, Tony
PMID: 27185461
Journal: Nat Commun. 2016 Jun 30;7:11960.
Title: Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia.
Author: Gao, Xue|Lin, Shu-Hai|Ren, Feng|Li, Jin-Tao|Chen, Jia-Jia|Yao, Chuan-Bo|Yang, Hong-Bin|Jiang, Shu-Xia|Yan, Guo-Quan|Wang, Di|Wang, Yi|Liu, Ying|Cai, Zongwei|Xu, Ying-Ying|Chen, Jing|Yu, Wenqiang|Yang, Peng-Yuan|Lei, Qun-Ying
PMID: 27357947
Journal: Chem Biol Interact. 2016 Aug 25;256:55-63.
Title: Utilization of metabonomics to identify serum biomarkers in murine H22 hepatocarcinoma and deduce antitumor mechanism of Rhizoma Paridis saponins.
Author: Qiu, Peiyu|Man, Shuli|Yang, He|Fan, Wei|Yu, Peng|Gao, Wenyuan
PMID: 27369806
Journal: Oncol Rep. 2016 Sep;36(3):1709-16.
Title: MicroRNA-1207-5p inhibits hepatocellular carcinoma cell growth and invasion through the fatty acid synthase-mediated Akt/mTOR signalling pathway.
Author: Zhao, Gang|Dong, Lei|Shi, Haitao|Li, Hong|Lu, Xiaolan|Guo, Xiaoyan|Wang, Jinhai
PMID: 27461404
Journal: Cancer Res. 2016 Dec 1;76(23):6924-6936.
Title: Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth.
Author: Lin, Huai-Peng|Cheng, Zhou-Li|He, Ruo-Yu|Song, Lei|Tian, Meng-Xin|Zhou, Li-Sha|Groh, Beezly S|Liu, Wei-Ren|Ji, Min-Biao|Ding, Chen|Shi, Ying-Hong|Guan, Kun-Liang|Ye, Dan|Xiong, Yue
PMID: 27758890
Journal: Carcinogenesis. 2017 Jan;38(1):94-104.
Title: Eukaryotic translation initiation factor 5A2 promotes metabolic reprogramming in hepatocellular carcinoma cells.
Author: Cao, Ting-Ting|Lin, Shu-Hai|Fu, Li|Tang, Zhi|Che, Chi-Ming|Zhang, Li-Yi|Ming, Xiao-Yan|Liu, Teng-Fei|Tang, Xu-Ming|Tan, Bin-Bin|Xiang, Di|Li, Feng|Chan, On-Yee|Xie, Dan|Cai, Zongwei|Guan, Xin-Yuan
PMID: 27879277
Journal: Nutr Cancer. 2017 Nov-Dec;69(8):1272-1280.
Title: Silibinin Reduces the Impact of Obesity on Invasive Liver Cancer.
Author: Miethe, C|Nix, H|Martin, R|Hernandez, A R|Price, R S
PMID: 29068700
Journal: Mol Syst Biol. 2017 Aug 21;13(8):938.
Title: Network analyses identify liver-specific targets for treating liver diseases.
Author: Lee, Sunjae|Zhang, Cheng|Liu, Zhengtao|Klevstig, Martina|Mukhopadhyay, Bani|Bergentall, Mattias|Cinar, Resat|Stahlman, Marcus|Sikanic, Natasha|Park, Joshua K|Deshmukh, Sumit|Harzandi, Azadeh M|Kuijpers, Tim|Grotli, Morten|Elsasser, Simon J|Piening, Brian
PMID: 28827398
Journal: Oncogenesis. 2017 Jun 12;6(6):e347.
Title: TIP30 regulates lipid metabolism in hepatocellular carcinoma by regulating SREBP1 through the Akt/mTOR signaling pathway.
Author: Yin, F|Sharen, G|Yuan, F|Peng, Y|Chen, R|Zhou, X|Wei, H|Li, B|Jing, W|Zhao, J
PMID: 28604762
Journal: Int J Oncol. 2017 Mar;50(3):883-892.
Title: Inhibition of FASN suppresses migration, invasion and growth in hepatoma carcinoma cells by deregulating the HIF-1alpha/IGFBP1 pathway.
Author: Gong, Jiaojiao|Shen, Shasha|Yang, Yixuan|Qin, Si|Huang, Lifan|Zhang, Hongmin|Chen, Ling|Chen, Yaqin|Li, Shiying|She, Sha|Yang, Min|Ren, Hong|Hu, Huaidong
PMID: 28197637
Journal: Cell Cycle. 2017 Mar 19;16(6):499-507.
Title: Oncogene dependent requirement of fatty acid synthase in hepatocellular carcinoma.
Author: Che, Li|Pilo, Maria G|Cigliano, Antonio|Latte, Gavinella|Simile, Maria M|Ribback, Silvia|Dombrowski, Frank|Evert, Matthias|Chen, Xin|Calvisi, Diego F
PMID: 28118080
Journal: Liver Int. 2017 Jan;37(1):80-89.
Title: Both de novo synthetized and exogenous fatty acids support the growth of hepatocellular carcinoma cells.
Author: Cao, Dan|Song, Xinhua|Che, Li|Li, Xiaolei|Pilo, Maria G|Vidili, Gianpaolo|Porcu, Alberto|Solinas, Antonio|Cigliano, Antonio|Pes, Giovanni M|Ribback, Silvia|Dombrowski, Frank|Chen, Xin|Li, Lei|Calvisi, Diego F
PMID: 27264722
Journal: Sci Rep. 2018 Jan 10;8(1):309.
Title: 8u, a pro-apoptosis/cell cycle arrest compound, suppresses invasion and metastasis through HSP90alpha downregulating and PI3K/Akt inactivation in hepatocellular carcinoma cells.
Author: Wang, Ning|Chen, Shaopeng|Zhang, Bin|Li, Shangfu|Jin, Feng|Gao, Dan|Liu, Hongxia|Jiang, Yuyang
PMID: 29321577
Journal: J Cell Biochem. 2018 Jul;119(7):5864-5874.
Title: MicroRNA-190b regulates lipid metabolism and insulin sensitivity by targeting IGF-1 and ADAMTS9 in non-alcoholic fatty liver disease.
Author: Xu, Min|Zheng, Xi-Ming|Jiang, Fang|Qiu, Wei-Qiang
PMID: 29575055
Journal: J Steroid Biochem Mol Biol. 2018 Oct;183:159-166.
Title: Combinatorial treatment of Rhizoma Paridis saponins and sorafenib overcomes the intolerance of sorafenib.
Author: Yao, Jingwen|Man, Shuli|Dong, Honghong|Yang, Li|Ma, Long|Gao, Wenyuan
PMID: 29932973
Journal: Exp Mol Med. 2018 Aug 3;50(8):93.
Title: A secretome profile indicative of oleate-induced proliferation of HepG2 hepatocellular carcinoma cells.
Author: Park, Soyeon|Park, Ji-Hwan|Jung, Hee-Jung|Jang, Jin-Hyeok|Ahn, Sanghyun|Kim, Younah|Suh, Pann-Ghill|Chae, Sehyun|Yoon, Jong Hyuk|Ryu, Sung Ho|Hwang, Daehee
PMID: 30076294
Journal: J Exp Clin Cancer Res. 2018 Sep 3;37(1):211.
Title: Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours.
Author: Nwosu, Zeribe C|Battello, Nadia|Rothley, Melanie|Pioronska, Weronika|Sitek, Barbara|Ebert, Matthias P|Hofmann, Ute|Sleeman, Jonathan|Wolfl, Stefan|Meyer, Christoph|Megger, Dominik A|Dooley, Steven
PMID: 30176945
Journal: Mol Carcinog. 2018 Sep 4.
Title: Celecoxib alleviates AKT/c-Met-triggered rapid hepatocarcinogenesis by suppressing a novel COX-2/AKT/FASN cascade.
Author: Qiu, Zhenpeng|Zhang, Cong|Zhou, Junxuan|Hu, Junjie|Sheng, Lei|Li, Xin|Chen, Liang|Li, Xiang|Deng, Xukun|Zheng, Guohua
PMID: 30182439
Journal: Biomed Pharmacother. 2018 Sep 15;108:297-308.
Title: Bergapten inhibits liver carcinogenesis by modulating LXR/PI3K/Akt and IDOL/LDLR pathways.
Author: Pattanayak, Shakti Prasad|Bose, Pritha|Sunita, Priyashree|Siddique, Mohd Usman Mohd|Lapenna, Antonio
PMID: 30227322