Primary Site >> Liver Cancer
Gene >> FASN
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Ref: Pu-erh tea supplementation suppresses fatty acid synthase expression in the rat liver through downregulating Akt and JNK signalings as demonstrated in human hepatoma HepG2 cells. PMID: 16925113 |
Ref: Mallory body forming cells express the preneoplastic hepatocyte phenotype. PMID: 16413534 Ref: Growth arrest induced by C75, A fatty acid synthase inhibitor, was partially modulated by p38 MAPK but not by p53 in human hepatocellular carcinoma. PMID: 16855382 |
Ref: [Activation of liver X receptor regulates fatty acid synthase expression in diabetic liver]. PMID: 18756992 Ref: Hepatitis B virus X protein induces lipogenic transcription factor SREBP1 and fatty acid synthase through the activation of nuclear receptor LXRalpha. PMID: 18782084 Ref: Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and production. PMID: 18830996 |
Ref: Liver X receptor mediates hepatitis B virus X protein-induced lipogenesis in hepatitis B virus-associated hepatocellular carcinoma. PMID: 19105208 Ref: Inhibitory effects of four plants flavonoids extracts on fatty acid synthase. PMID: 25084411 |
Ref: A mutant of hepatitis B virus X protein (HBxDelta127) promotes cell growth through a positive feedback loop involving 5-lipoxygenase and fatty acid synthase. PMID: 20126469 Ref: Identification of autoantibody against fatty acid synthase in hepatocellular carcinoma mouse model and its application to diagnosis of HCC. PMID: 20428769 Ref: Fatty acid synthase inhibitor cerulenin suppresses liver metastasis of colon cancer in mice. PMID: 20491775 |
Ref: Polyunsaturated fatty acids reduce fatty acid synthase and hydroxy-methyl-glutaryl CoA-reductase gene expression and promote apoptosis in HepG2 cell line. PMID: 21244676 |
Ref: Diet-induced obesity increases melanoma progression: involvement of Cav-1 and FASN. PMID: 21387314 Ref: Combined phosphatase and tensin homolog (PTEN) loss and fatty acid synthase (FAS) overexpression worsens the prognosis of Chinese patients with hepatocellular carcinoma. PMID: 22949843 |
Ref: Dietary supplementation with methyl donors reduces fatty liver and modifies the fatty acid synthase DNA methylation profile in rats fed an obesogenic diet. PMID: 22648174 Ref: Hepatitis C virus replication is modulated by the interaction of nonstructural protein NS5B and fatty acid synthase. PMID: 23427160 Ref: Inherent and acquired resistance to paclitaxel in hepatocellular carcinoma: molecular events involved. PMID: 23613870 |
Ref: Curcumin induces apoptosis of HepG2 cells via inhibiting fatty acid synthase. PMID: 23821378 Ref: Kefir improves fatty liver syndrome by inhibiting the lipogenesis pathway in leptin-deficient ob/ob knockout mice. PMID: 24335764 Ref: Forkhead box transcription factor regulation and lipid accumulation by hepatitis C virus. PMID: 24478438 Ref: In situ proteome profiling of C75, a covalent bioactive compound with potential anticancer activities. PMID: 24552542 Ref: The effect and mechanism of tamoxifen-induced hepatocyte steatosis in vitro. PMID: 24603540 Ref: Luteolin alleviates alcoholic liver disease induced by chronic and binge ethanol feeding in mice. PMID: 24828027 Ref: Quercetin induces HepG2 cell apoptosis by inhibiting fatty acid biosynthesis. PMID: 25009654 Ref: MicroRNA-449 suppresses proliferation of hepatoma cell lines through blockade lipid metabolic pathway related to SIRT1. PMID: 25119660 Ref: Expression and roles of fatty acid synthase in hepatocellular carcinoma. PMID: 25231933 |
Ref: Polymorphisms in genes of the de novo lipogenesis pathway and overall survival of hepatocellular carcinoma patients undergoing transarterial chemoembolization. PMID: 25735330 Ref: Genetic variants in de novo lipogenic pathway genes predict the prognosis of surgically-treated hepatocellular carcinoma. PMID: 25826294 Ref: CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARalpha pathways. PMID: 26282231 |
Ref: Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans. PMID: 26476289 Ref: [(11)C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice. PMID: 26567114 Ref: Improvement of mTORC1-driven overproduction of apoB-containing triacylglyceride-rich lipoproteins by short-chain fatty acids, 4-phenylbutyric acid and (R)-alpha-lipoic acid, in human hepatocellular carcinoma cells. PMID: 26680362 Ref: Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice. PMID: 26857837 Ref: Differential requirement for de novo lipogenesis in cholangiocarcinoma and hepatocellular carcinoma of mice and humans. PMID: 26910791 Ref: Artemisia capillaris formula inhibits hepatic steatosis via an miR122induced decrease in fatty acid synthase expression in vivo and in vitro. PMID: 27081834 Ref: The Nutrient-Dependent O-GlcNAc Modification Controls the Expression of Liver Fatty Acid Synthase. PMID: 27185461 Ref: Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. PMID: 27357947 Ref: Utilization of metabonomics to identify serum biomarkers in murine H22 hepatocarcinoma and deduce antitumor mechanism of Rhizoma Paridis saponins. PMID: 27369806 Ref: MicroRNA-1207-5p inhibits hepatocellular carcinoma cell growth and invasion through the fatty acid synthase-mediated Akt/mTOR signalling pathway. PMID: 27461404 Ref: Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth. PMID: 27758890 |
Ref: Both de novo synthetized and exogenous fatty acids support the growth of hepatocellular carcinoma cells. PMID: 27264722 Ref: Eukaryotic translation initiation factor 5A2 promotes metabolic reprogramming in hepatocellular carcinoma cells. PMID: 27879277 Ref: Oncogene dependent requirement of fatty acid synthase in hepatocellular carcinoma. PMID: 28118080 Ref: Inhibition of FASN suppresses migration, invasion and growth in hepatoma carcinoma cells by deregulating the HIF-1alpha/IGFBP1 pathway. PMID: 28197637 Ref: TIP30 regulates lipid metabolism in hepatocellular carcinoma by regulating SREBP1 through the Akt/mTOR signaling pathway. PMID: 28604762 Ref: Network analyses identify liver-specific targets for treating liver diseases. PMID: 28827398 Ref: Silibinin Reduces the Impact of Obesity on Invasive Liver Cancer. PMID: 29068700 |
Ref: 8u, a pro-apoptosis/cell cycle arrest compound, suppresses invasion and metastasis through HSP90alpha downregulating and PI3K/Akt inactivation in hepatocellular carcinoma cells. PMID: 29321577 Ref: MicroRNA-190b regulates lipid metabolism and insulin sensitivity by targeting IGF-1 and ADAMTS9 in non-alcoholic fatty liver disease. PMID: 29575055 Ref: Combinatorial treatment of Rhizoma Paridis saponins and sorafenib overcomes the intolerance of sorafenib. PMID: 29932973 Ref: A secretome profile indicative of oleate-induced proliferation of HepG2 hepatocellular carcinoma cells. PMID: 30076294 Ref: Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours. PMID: 30176945 Ref: Celecoxib alleviates AKT/c-Met-triggered rapid hepatocarcinogenesis by suppressing a novel COX-2/AKT/FASN cascade. PMID: 30182439 Ref: Bergapten inhibits liver carcinogenesis by modulating LXR/PI3K/Akt and IDOL/LDLR pathways. PMID: 30227322 |