Primary Site >> Colorectal Cancer

Gene >> F2RL1

Journal: Br J Cancer. 2001 Sep 1;85(5):772-9.
Title: Initiation of human colon cancer cell proliferation by trypsin acting at protease-activated receptor-2.
Author: Darmoul, D|Marie, J C|Devaud, H|Gratio, V|Laburthe, M
PMID: 11531266
Journal: Life Sci. 2002 Feb 8;70(12):1359-67.
Title: Trypsin is produced by and activates protease-activated receptor-2 in human cancer colon cells: evidence for new autocrine loop.
Author: Ducroc, Robert|Bontemps, Claire|Marazova, Katia|Devaud, Helene|Darmoul, Dalila|Laburthe, Marc
PMID: 11883712
Journal: Life Sci. 2003 Oct 17;73(22):2817-29.
Title: MAP kinase-mediated proliferation of DLD-1 carcinoma by the stimulation of protease-activated receptor 2.
Author: Jikuhara, Atsushi|Yoshii, Masanori|Iwagaki, Hiromi|Mori, Shuji|Nishibori, Masahiro|Tanaka, Noriaki
PMID: 14511767
Journal: J Biol Chem. 2004 May 14;279(20):20927-34. Epub 2004 Mar 9.
Title: Protease-activated receptor 2 in colon cancer: trypsin-induced MAPK phosphorylation and cell proliferation are mediated by epidermal growth factor receptor transactivation.
Author: Darmoul, Dalila|Gratio, Valerie|Devaud, Helene|Laburthe, Marc
PMID: 15010475
Journal: J Pharmacol Sci. 2005 Jan;97(1):25-30. Epub 2005 Jan 15.
Title: Physiology and pathophysiology of proteinase-activated receptors (PARs): PAR-2-mediated proliferation of colon cancer cell.
Author: Nishibori, Masahiro|Mori, Shuji|Takahashi, Hideo K
PMID: 15655297
Journal: Mem Inst Oswaldo Cruz. 2005 Mar;100 Suppl 1:211-5.
Title: Epithelial effects of proteinase-activated receptors in the gastrointestinal tract.
Author: MacNaughton, Wallace K
PMID: 15962125
Journal: J Pharmacol Sci. 2005 Aug;98(4):450-8. Epub 2005 Aug 10.
Title: Mast cell tryptase stimulates DLD-1 carcinoma through prostaglandin- and MAP kinase-dependent manners.
Author: Yoshii, Masanori|Jikuhara, Atsushi|Mori, Shuji|Iwagaki, Hiromi|Takahashi, Hideo K|Nishibori, Masahiro|Tanaka, Noriaki
PMID: 16093613
Journal: J Pathol. 2006 Jun;209(2):147-56.
Title: Trypsin in colorectal cancer: molecular biological mechanisms of proliferation, invasion, and metastasis.
Author: Soreide, K|Janssen, E A|Korner, H|Baak, J P A
PMID: 16691544
Journal: Biochem Biophys Res Commun. 2008 Dec 12;377(2):622-6.
Title: PAR2 triggers IL-8 release via MEK/ERK and PI3-kinase/Akt pathways in GI epithelial cells.
Author: Tanaka, Yusuke|Sekiguchi, Fumiko|Hong, Hao|Kawabata, Atsufumi
PMID: 18854173
Journal: Oncol Rep. 2008 Nov;20(5):1069-76.
Title: The expression and the functional roles of tissue factor and protease-activated receptor-2 on SW620 cells.
Author: Zhou, Hong|Hu, Hongxin|Shi, Wenxia|Ling, Shucai|Wang, Ting|Wang, Haibo
PMID: 18949403
Journal: Zhonghua Zhong Liu Za Zhi. 2009 Jul;31(7):485-9.
Title: [Investigation of the mechanisms of coagulation factor VIIa-induced colon cancer SW620 cell proliferation and migration].
Author: Shi, Wen-Xia|Zhou, Hong|Li, Na|Huang, Hong-Liang|Zhou, Bao-Cheng
PMID: 19950693
Journal: Am J Pathol. 2010 Mar;176(3):1452-61.
Title: Kallikrein-related peptidase 4: a new activator of the aberrantly expressed protease-activated receptor 1 in colon cancer cells.
Author: Gratio, Valerie|Beaufort, Nathalie|Seiz, Lina|Maier, Josefine|Virca, G Duke|Debela, Mekdes|Grebenchtchikov, Nicolai|Magdolen, Viktor|Darmoul, Dalila
PMID: 20056842
Journal: Dis Colon Rectum. 2010 Aug;53(8):1202-8.
Title: Expression of protease activated receptor-2 in human colorectal cancer and its association with tumor progression.
Author: Chang, Jae Hyuck|Park, Jae Myung|Kim, Sang Woo|Jung, Chan Kwon|Kang, Won Kyung|Oh, Seong Taek
PMID: 20628286
Journal: J Med Chem. 2010 Oct 28;53(20):7428-40.
Title: Novel agonists and antagonists for human protease activated receptor 2.
Author: Barry, Grant D|Suen, Jacky Y|Le, Giang T|Cotterell, Adam|Reid, Robert C|Fairlie, David P
PMID: 20873792
Journal: Mol Med Rep. 2010 Mar-Apr;3(2):269-74.
Title: Tissue factor-factor VIIa regulates interleukin-8, tissue factor and caspase-7 expression in SW620 cells through protease-activated receptor-2 activation.
Author: Zhou, Hong|Shi, Wenxia|Zhou, Baocheng|Guo, Donglin|Wang, Ting
PMID: 21472232
Journal: Zhonghua Zhong Liu Za Zhi. 2011 Sep;33(9):649-53.
Title: [Role of NF-kappaB in factor VIIa-induced proliferation and migration of colon cancer cell line SW620 cells].
Author: Guo, Dong-lin|Zhou, Hong|Wu, Ying|Zhou, Fang|Zhang, Xian-mei|Xu, Guo-ying|Wen, Hai-ping
PMID: 22340043
Journal: Am J Pathol. 2011 Nov;179(5):2625-36.
Title: Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells.
Author: Gratio, Valerie|Loriot, Celine|Virca, G Duke|Oikonomopoulou, Katerina|Walker, Francine|Diamandis, Eleftherios P|Hollenberg, Morley D|Darmoul, Dalila
PMID: 21907696
Journal: Proc Natl Acad Sci U S A. 2011 May 17;108(20):8491-6.
Title: Interdicting protease-activated receptor-2-driven inflammation with cell-penetrating pepducins.
Author: Sevigny, Leila M|Zhang, Ping|Bohm, Andrew|Lazarides, Katherine|Perides, George|Covic, Lidija|Kuliopulos, Athan
PMID: 21536878
Journal: Oncol Rep. 2011 Feb;25(2):503-11.
Title: Activation of PAR2 or/and TLR4 promotes SW620 cell proliferation and migration via phosphorylation of ERK1/2.
Author: Zhou, Baocheng|Zhou, Hong|Ling, Shucai|Guo, Donglin|Yan, Yihong|Zhou, Fang|Wu, Ying
PMID: 21152870
Journal: Tumour Biol. 2011 Oct;32(5):921-30.
Title: Involvement of ERK1/2/NF-kappaB signal transduction pathway in TF/FVIIa/PAR2-induced proliferation and migration of colon cancer cell SW620.
Author: Guo, Donglin|Zhou, Hong|Wu, Ying|Zhou, Fang|Xu, Guoying|Wen, Haiping|Zhang, Xianmei
PMID: 21625939
Journal: Acta Pharmacol Sin. 2012 Jan;33(1):120-6.
Title: Epigallocatechin-3-gallate inhibits proliferation and migration of human colon cancer SW620 cells in vitro.
Author: Zhou, Fang|Zhou, Hong|Wang, Ting|Mu, Yuan|Wu, Biao|Guo, Dong-lin|Zhang, Xian-mei|Wu, Ying
PMID: 22101170
Journal: Biol Chem. 2012 Apr;393(5):413-20.
Title: Kallikrein-related peptidase signaling in colon carcinoma cells: targeting proteinase-activated receptors.
Author: Chung, Hyunjae|Hamza, Magda|Oikonomopoulou, Katerina|Gratio, Valerie|Saifeddine, Mahmoud|Virca, G Duke|Diamandis, Eleftherios P|Hollenberg, Morley D|Darmoul, Dalila
PMID: 22505523
Journal: Am J Physiol Gastrointest Liver Physiol. 2012 Jul;303(1):G111-9.
Title: Epidermal growth factor receptor transactivation is required for proteinase-activated receptor-2-induced COX-2 expression in intestinal epithelial cells.
Author: Hirota, Christina L|Moreau, France|Iablokov, Vadim|Dicay, Michael|Renaux, Bernard|Hollenberg, Morley D|MacNaughton, Wallace K
PMID: 22517768
Journal: J Cell Mol Med. 2013 Aug;17(8):1025-37.
Title: High density of tryptase-positive mast cells in human colorectal cancer: a poor prognostic factor related to protease-activated receptor 2 expression.
Author: Malfettone, Andrea|Silvestris, Nicola|Saponaro, Concetta|Ranieri, Girolamo|Russo, Antonio|Caruso, Stefano|Popescu, Ondina|Simone, Giovanni|Paradiso, Angelo|Mangia, Anita
PMID: 23991686
Journal: PLoS One. 2013 Aug 26;8(8):e72383.
Title: MicroRNA-34a mediates the autocrine signaling of PAR2-activating proteinase and its role in colonic cancer cell proliferation.
Author: Ma, Yiming|Bao-Han, Wuyun|Lv, Xue|Su, Yuntao|Zhao, Xinhua|Yin, Yongmei|Zhang, Xingmao|Zhou, Zhixiang|MacNaughton, Wallace K|Wang, Hongying
PMID: 23991105
Journal: Tumour Biol. 2013 Oct;34(5):2573-81.
Title: TF/FVIIa/PAR2 promotes cell proliferation and migration via PKCalpha and ERK-dependent c-Jun/AP-1 pathway in colon cancer cell line SW620.
Author: Hu, Lichao|Xia, Longfei|Zhou, Hong|Wu, Biao|Mu, Yuan|Wu, Ying|Yan, Jinchuan
PMID: 23616010
Journal: Tumour Biol. 2013 Apr;34(2):837-46.
Title: Involvement of PKCalpha activation in TF/VIIa/PAR2-induced proliferation, migration, and survival of colon cancer cell SW620.
Author: Wu, Biao|Zhou, Hong|Hu, Lichao|Mu, Yuan|Wu, Ying
PMID: 23233043
Journal: Cancer Invest. 2013 Jan;31(1):7-16.
Title: Factor VIIa regulates the expression of caspase-3, MMP-9, and CD44 in SW620 colon cancer cells involving PAR2/MAPKs/NF-kappaB signaling pathways.
Author: Wu, Ying|Zhang, Xianmei|Zhou, Hong|Chen, Dongdong|Xie, Hongxiang|Mu, Yuan|Wu, Biao|Yan, Jinchuan
PMID: 23170789
Journal: Arch Biochem Biophys. 2014 Aug;555-556:28-32.
Title: Activated protease receptor-2 induces GATA6 expression to promote survival in irradiated colon cancer cells.
Author: Cai, Wen-song|Shen, Fei|Li, Jiang-lin|Feng, Zhe|Wang, Ying-cheng|Xiao, Huan-qing|Xu, Bo
PMID: 24887481
Journal: Mol Med Rep. 2014 Dec;10(6):3021-6.
Title: Effects of calcium signaling on coagulation factor VIIa-induced proliferation and migration of the SW620 colon cancer cell line.
Author: Wu, Ying|Wang, Jing|Zhou, Hong|Yu, Xiaoyan|Hu, Lichao|Meng, Fanlu|Jiang, Shuanghong
PMID: 25323578
Journal: J Biol Chem. 2015 Oct 30;290(44):26627-37.
Title: Proteinase-activated receptor 2 promotes cancer cell migration through RNA methylation-mediated repression of miR-125b.
Author: Yang, Lan|Ma, Yiming|Han, Wenxiao|Li, Weiwei|Cui, Liang|Zhao, Xinhua|Tian, Yantao|Zhou, Zhixiang|Wang, Wengong|Wang, Hongying
PMID: 26354435
Journal: Thromb Res. 2016 Apr;140 Suppl 1:S195.
Title: PO-51 - Expression of proteins of the tissue factor thrombin pathway is upregulated in the stroma and epithelium of colorectal cancer.
Author: Clouston, H W|Davenport, A|Gregson, H|Shaker, H|Duff, S|Kirwan, C C
PMID: 27161738
Journal: BMC Cancer. 2016 May 31;16:341.
Title: Cross-talk between the Tissue Factor/coagulation factor VIIa complex and the tyrosine kinase receptor EphA2 in cancer.
Author: Eriksson, Oskar|Thulin, Asa|Asplund, Anna|Hegde, Geeta|Navani, Sanjay|Siegbahn, Agneta
PMID: 27246245
Journal: Am J Physiol Gastrointest Liver Physiol. 2016 Aug 1;311(2):G221-36.
Title: PAR2-dependent activation of GSK3beta regulates the survival of colon stem/progenitor cells.
Author: Nasri, Imen|Bonnet, Delphine|Zwarycz, Bailey|d'Aldebert, Emilie|Khou, Sokchea|Mezghani-Jarraya, Raoudha|Quaranta, Muriel|Rolland, Corinne|Bonnart, Chrystelle|Mas, Emmanuel|Ferrand, Audrey|Cenac, Nicolas|Magness, Scott|Van Landeghem, Laurianne|Vergnolle, N
PMID: 27313176
Journal: ACS Chem Biol. 2017 May 19;12(5):1217-1226.
Title: Biased Signaling by Agonists of Protease Activated Receptor 2.
Author: Jiang, Yuhong|Yau, Mei-Kwan|Kok, W Mei|Lim, Junxian|Wu, Kai-Chen|Liu, Ligong|Hill, Timothy A|Suen, Jacky Y|Fairlie, David P
PMID: 28169521
Journal: Cell Biochem Funct. 2017 Oct;35(7):401-406.
Title: LRF inhibits p53 expression in colon cancer cells via modulating DAP5 activity.
Author: Zhu, Min|Wang, Peng|Feng, Fan|Li, Ming-Yang
PMID: 28849590
Journal: Cancer Invest. 2017 Oct 21;35(9):601-609.
Title: MicroRNA-205 Mediates Proteinase-Activated Receptor 2 (PAR2) -Promoted Cancer Cell Migration.
Author: Yang, Xu|Yang, Lan|Ma, Yiming|Zhao, Xinhua|Wang, Hongying
PMID: 28990808