Primary Site >> Colorectal Cancer
Gene >> F2RL1
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Ref: Initiation of human colon cancer cell proliferation by trypsin acting at protease-activated receptor-2. PMID: 11531266 |
Ref: Trypsin is produced by and activates protease-activated receptor-2 in human cancer colon cells: evidence for new autocrine loop. PMID: 11883712 |
Ref: MAP kinase-mediated proliferation of DLD-1 carcinoma by the stimulation of protease-activated receptor 2. PMID: 14511767 |
Ref: Protease-activated receptor 2 in colon cancer: trypsin-induced MAPK phosphorylation and cell proliferation are mediated by epidermal growth factor receptor transactivation. PMID: 15010475 |
Ref: Physiology and pathophysiology of proteinase-activated receptors (PARs): PAR-2-mediated proliferation of colon cancer cell. PMID: 15655297 Ref: Epithelial effects of proteinase-activated receptors in the gastrointestinal tract. PMID: 15962125 Ref: Mast cell tryptase stimulates DLD-1 carcinoma through prostaglandin- and MAP kinase-dependent manners. PMID: 16093613 |
Ref: Trypsin in colorectal cancer: molecular biological mechanisms of proliferation, invasion, and metastasis. PMID: 16691544 |
Ref: PAR2 triggers IL-8 release via MEK/ERK and PI3-kinase/Akt pathways in GI epithelial cells. PMID: 18854173 Ref: The expression and the functional roles of tissue factor and protease-activated receptor-2 on SW620 cells. PMID: 18949403 |
Ref: [Investigation of the mechanisms of coagulation factor VIIa-induced colon cancer SW620 cell proliferation and migration]. PMID: 19950693 |
Ref: Kallikrein-related peptidase 4: a new activator of the aberrantly expressed protease-activated receptor 1 in colon cancer cells. PMID: 20056842 Ref: Expression of protease activated receptor-2 in human colorectal cancer and its association with tumor progression. PMID: 20628286 Ref: Novel agonists and antagonists for human protease activated receptor 2. PMID: 20873792 Ref: Tissue factor-factor VIIa regulates interleukin-8, tissue factor and caspase-7 expression in SW620 cells through protease-activated receptor-2 activation. PMID: 21472232 |
Ref: Activation of PAR2 or/and TLR4 promotes SW620 cell proliferation and migration via phosphorylation of ERK1/2. PMID: 21152870 Ref: Interdicting protease-activated receptor-2-driven inflammation with cell-penetrating pepducins. PMID: 21536878 Ref: Involvement of ERK1/2/NF-kappaB signal transduction pathway in TF/FVIIa/PAR2-induced proliferation and migration of colon cancer cell SW620. PMID: 21625939 Ref: Kallikrein-related peptidase 14 acts on proteinase-activated receptor 2 to induce signaling pathway in colon cancer cells. PMID: 21907696 Ref: [Role of NF-kappaB in factor VIIa-induced proliferation and migration of colon cancer cell line SW620 cells]. PMID: 22340043 |
Ref: Epigallocatechin-3-gallate inhibits proliferation and migration of human colon cancer SW620 cells in vitro. PMID: 22101170 Ref: Kallikrein-related peptidase signaling in colon carcinoma cells: targeting proteinase-activated receptors. PMID: 22505523 Ref: Epidermal growth factor receptor transactivation is required for proteinase-activated receptor-2-induced COX-2 expression in intestinal epithelial cells. PMID: 22517768 |
Ref: Factor VIIa regulates the expression of caspase-3, MMP-9, and CD44 in SW620 colon cancer cells involving PAR2/MAPKs/NF-kappaB signaling pathways. PMID: 23170789 Ref: Involvement of PKCalpha activation in TF/VIIa/PAR2-induced proliferation, migration, and survival of colon cancer cell SW620. PMID: 23233043 Ref: TF/FVIIa/PAR2 promotes cell proliferation and migration via PKCalpha and ERK-dependent c-Jun/AP-1 pathway in colon cancer cell line SW620. PMID: 23616010 Ref: MicroRNA-34a mediates the autocrine signaling of PAR2-activating proteinase and its role in colonic cancer cell proliferation. PMID: 23991105 Ref: High density of tryptase-positive mast cells in human colorectal cancer: a poor prognostic factor related to protease-activated receptor 2 expression. PMID: 23991686 |
Ref: Activated protease receptor-2 induces GATA6 expression to promote survival in irradiated colon cancer cells. PMID: 24887481 Ref: Effects of calcium signaling on coagulation factor VIIa-induced proliferation and migration of the SW620 colon cancer cell line. PMID: 25323578 |
Ref: Proteinase-activated receptor 2 promotes cancer cell migration through RNA methylation-mediated repression of miR-125b. PMID: 26354435 |
Ref: PO-51 - Expression of proteins of the tissue factor thrombin pathway is upregulated in the stroma and epithelium of colorectal cancer. PMID: 27161738 Ref: Cross-talk between the Tissue Factor/coagulation factor VIIa complex and the tyrosine kinase receptor EphA2 in cancer. PMID: 27246245 Ref: PAR2-dependent activation of GSK3beta regulates the survival of colon stem/progenitor cells. PMID: 27313176 |
Ref: Biased Signaling by Agonists of Protease Activated Receptor 2. PMID: 28169521 Ref: LRF inhibits p53 expression in colon cancer cells via modulating DAP5 activity. PMID: 28849590 Ref: MicroRNA-205 Mediates Proteinase-Activated Receptor 2 (PAR2) -Promoted Cancer Cell Migration. PMID: 28990808 |