Primary Site >> Colorectal Cancer

Gene >> EPHB2

Journal: Cell Growth Differ. 1996 May;7(5):587-94.
Title: Protein kinase C beta 1 and protein kinase C beta 2 activate p57 mitogen-activated protein kinase and block differentiation in colon carcinoma cells.
Author: Sauma, S|Yan, Z|Ohno, S|Friedman, E
PMID: 8732668
Journal: Oncogene. 1997 May 29;14(21):2563-73.
Title: Elevated urokinase-type plasminogen activator receptor expression in a colon cancer cell line is due to a constitutively activated extracellular signal-regulated kinase-1-dependent signaling cascade.
Author: Lengyel, E|Wang, H|Gum, R|Simon, C|Wang, Y|Boyd, D
PMID: 9191056
Journal: Oncogene. 1997 Nov 27;15(22):2705-16.
Title: ErbB kinases and NDF signaling in human prostate cancer cells.
Author: Grasso, A W|Wen, D|Miller, C M|Rhim, J S|Pretlow, T G|Kung, H J
PMID: 9400997
Journal: Gastroenterology. 1998 Nov;115(5):1144-53.
Title: Oncogenic ras induces gastrin gene expression in colon cancer.
Author: Nakata, H|Wang, S L|Chung, D C|Westwick, J K|Tillotson, L G
PMID: 9797369
Journal: Oncogene. 1999 Mar 11;18(10):1807-17.
Title: Differential contribution of the ERK and JNK mitogen-activated protein kinase cascades to Ras transformation of HT1080 fibrosarcoma and DLD-1 colon carcinoma cells.
Author: Plattner, R|Gupta, S|Khosravi-Far, R|Sato, K Y|Perucho, M|Der, C J|Stanbridge, E J
PMID: 10086335
Journal: Gastroenterology. 1999 May;116(5):1072-80.
Title: Mitogen-activated protein kinase activation regulates intestinal epithelial differentiation.
Author: Taupin, D|Podolsky, D K
PMID: 10220499
Journal: Carcinogenesis. 1999 May;20(5):785-91.
Title: Carcinogen and dietary lipid regulate ras expression and localization in rat colon without affecting farnesylation kinetics.
Author: Davidson, L A|Lupton, J R|Jiang, Y H|Chapkin, R S
PMID: 10334194
Journal: Mol Med. 1999 Mar;5(3):147-59.
Title: Glycine-extended gastrin exerts growth-promoting effects on human colon cancer cells.
Author: Stepan, V M|Sawada, M|Todisco, A|Dickinson, C J
PMID: 10404512
Journal: Cancer Res. 1999 Oct 1;59(19):4804-7.
Title: Extracellular signal-regulated kinase activation is required for up-regulation of vascular endothelial growth factor by serum starvation in human colon carcinoma cells.
Author: Jung, Y D|Nakano, K|Liu, W|Gallick, G E|Ellis, L M
PMID: 10519388
Journal: Nat Med. 1999 Dec;5(12):1418-23.
Title: Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing.
Author: Jones, M K|Wang, H|Peskar, B M|Levin, E|Itani, R M|Sarfeh, I J|Tarnawski, A S
PMID: 10581086
Journal: J Biol Chem. 1999 Dec 10;274(50):35505-13.
Title: 1,25-Dihydroxyvitamin D(3) stimulates activator protein-1-dependent Caco-2 cell differentiation.
Author: Chen, A|Davis, B H|Bissonnette, M|Scaglione-Sewell, B|Brasitus, T A
PMID: 10585423
Journal: J Biol Chem. 2000 May 19;275(20):15090-8.
Title: Bile acid-induced activation of activator protein-1 requires both extracellular signal-regulated kinase and protein kinase C signaling.
Author: Qiao, D|Chen, W|Stratagoules, E D|Martinez, J D
PMID: 10748108
Journal: Oncogene. 2000 Apr 6;19(15):1901-14.
Title: Defective cleavage of membrane bound TGFalpha leads to enhanced activation of the EGF receptor in malignant cells.
Author: Yang, H|Jiang, D|Li, W|Liang, J|Gentry, L E|Brattain, M G
PMID: 10773880
Journal: Cancer Res. 2000 Jul 1;60(13):3631-7.
Title: Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells.
Author: Lee, K|Deng, X|Friedman, E
PMID: 10910078
Journal: Zentralbl Chir. 2000;125 Suppl 1:12-5.
Title: [Deregulation of intracellular signal pathways in colorectal carcinoma].
Author: Troppmair, J|Rapp, U R
PMID: 10929640
Journal: Biochem J. 2000 Dec 1;352 Pt 2:419-24.
Title: Induction of prostaglandin endoperoxide synthase 2 by mitogen-activated protein kinase cascades.
Author: McGinty, A|Foschi, M|Chang, Y W|Han, J|Dunn, M J|Sorokin, A
PMID: 11085935
Journal: Cancer Lett. 2001 Mar 10;164(1):97-104.
Title: Genomic structure and loss of heterozygosity of EPHB2 in colorectal cancer.
Author: Oba, S M|Wang, Y J|Song, J P|Li, Z Y|Kobayashi, K|Tsugane, S|Hamada, G S|Tanaka, M|Sugimura, H
PMID: 11166921
Journal: Am J Physiol Cell Physiol. 2001 May;280(5):C1066-75.
Title: n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in colonocytes.
Author: Collett, E D|Davidson, L A|Fan, Y Y|Lupton, J R|Chapkin, R S
PMID: 11287318
Journal: Eur J Cell Biol. 2001 Mar;80(3):213-21.
Title: Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells.
Author: Chen, Y C|Tsai, S H|Shen, S C|Lin, J K|Lee, W R
PMID: 11322385
Journal: Biochem Biophys Res Commun. 2001 Jun 8;284(2):282-8.
Title: Alterations of MAPK activities associated with intestinal cell differentiation.
Author: Ding, Q|Wang, Q|Evers, B M
PMID: 11394874
Journal: Eur J Cancer Prev. 2001 Aug;10(4):313-21.
Title: Butyrate and propionate downregulate ERK phosphorylation in HT-29 colon carcinoma cells prior to differentiation.
Author: Davido, D J|Richter, F|Boxberger, F|Stahl, A|Menzel, T|Luhrs, H|Loffler, S|Dusel, G|Rapp, U R|Scheppach, W
PMID: 11535873
Journal: Oncol Rep. 2001 Nov-Dec;8(6):1409-13.
Title: Upregulation of non-mutated H-ras and its upstream and downstream signaling proteins in colorectal cancer.
Author: Feng, J|Hua, F|Shuo, R|Chongfeng, G|Huimian, X|Nakajima, T|Subao, W|Tsuchida, N
PMID: 11605075
Journal: Oncogene. 2001 Dec 6;20(56):8066-74.
Title: Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells.
Author: Yao, J|Xiong, S|Klos, K|Nguyen, N|Grijalva, R|Li, P|Yu, D
PMID: 11781819
Journal: Oncogene. 2002 Jan 3;21(1):78-86.
Title: Autocrine heregulin generates growth factor independence and blocks apoptosis in colon cancer cells.
Author: Venkateswarlu, Srinivas|Dawson, Dawn M|St Clair, Patricia|Gupta, Anjana|Willson, James K V|Brattain, Michael G
PMID: 11791178
Journal: Oncogene. 2002 Feb 21;21(9):1370-80.
Title: Direct integrin alphavbeta6-ERK binding: implications for tumour growth.
Author: Ahmed, Nuzhat|Niu, Jun|Dorahy, Douglas J|Gu, Xinhua|Andrews, Sarah|Meldrum, Cliff J|Scott, Rodney J|Baker, Mark S|Macreadie, Ian G|Agrez, Michael V
PMID: 11857080
Journal: Cancer. 2002 Feb 15;94(4):934-9.
Title: Coexpression of ephrin-Bs and their receptors in colon carcinoma.
Author: Liu, Wenbiao|Ahmad, Syed A|Jung, Young D|Reinmuth, Niels|Fan, Fan|Bucana, Corazon D|Ellis, Lee M
PMID: 11920461
Journal: Exp Mol Med. 2002 Mar 31;34(1):27-31.
Title: Differential modulation of zinc-stimulated p21(Cip/WAF1) and cyclin D1 induction by inhibition of PI3 kinase in HT-29 colorectal cancer cells.
Author: Oh, So-Young|Park, Ki-Sook|Kim, Jin-Ah|Choi, Kang-Yell
PMID: 11989975
Journal: Int J Cancer. 2002 Jun 1;99(4):529-37.
Title: Integrin expression in colon cancer cells is regulated by the cytoplasmic domain of the beta6 integrin subunit.
Author: Niu, Jun|Dorahy, Douglas J|Gu, Xinhua|Scott, R J|Draganic, Brian|Ahmed, Nuzhat|Agrez, Michael V
PMID: 11992542
Journal: J Biol Chem. 2002 Sep 6;277(36):32624-31. Epub 2002 Jun 20.
Title: Phorbol 12-myristate 13-acetate up-regulates the transcription of MUC2 intestinal mucin via Ras, ERK, and NF-kappa B.
Author: Lee, Hae-Wan|Ahn, Dae-Ho|Crawley, Suzanne C|Li, Jian-Dong|Gum, James R Jr|Basbaum, Carol B|Fan, Nancy Q|Szymkowski, David E|Han, Sang-Young|Lee, Bong H|Sleisenger, Marvin H|Kim, Young S
PMID: 12077118
Journal: Br J Pharmacol. 2002 Nov;137(5):597-607.
Title: Extracellular zinc stimulates ERK-dependent activation of p21(Cip/WAF1) and inhibits proliferation of colorectal cancer cells.
Author: Park, Ki-Sook|Ahn, Yongho|Kim, Jin-Ah|Yun, Mi-Sun|Seong, Baik L|Choi, Kang-Yell
PMID: 12381673
Journal: J Pharmacol Exp Ther. 2002 Nov;303(2):711-5.
Title: Perturbation by geraniol of cell membrane permeability and signal transduction pathways in human colon cancer cells.
Author: Carnesecchi, S|Bradaia, A|Fischer, B|Coelho, D|Scholler-Guinard, M|Gosse, F|Raul, F
PMID: 12388655
Journal: Cell. 2002 Oct 18;111(2):251-63.
Title: Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB.
Author: Batlle, Eduard|Henderson, Jeffrey T|Beghtel, Harry|van den Born, Maaike M W|Sancho, Elena|Huls, Gerwin|Meeldijk, Jan|Robertson, Jennifer|van de Wetering, Marc|Pawson, Tony|Clevers, Hans
PMID: 12408869
Journal: Br Med Bull. 2002;64:227-54.
Title: Therapeutics targeting signal transduction for patients with colorectal carcinoma.
Author: de Bono, Johann S|Rowinsky, Eric K
PMID: 12421735
Journal: Expert Rev Mol Med. 2002 Apr 25;4(8):1-18.
Title: The role of Raf kinases in malignant transformation.
Author: Kolch, Walter|Kotwaliwale, Ashwin|Vass, Keith|Janosch, Petra
PMID: 14987392
Journal: Proteomics. 2003 Mar;3(3):288-98.
Title: Proteomic profiling of proteins associated with urokinase plasminogen activator receptor in a colon cancer cell line using an antisense approach.
Author: Ahmed, Nuzhat|Oliva, Karen|Wang, Yao|Quinn, Michael|Rice, Greg
PMID: 12627382
Journal: J Biol Chem. 2003 May 30;278(22):19861-9.
Title: Integrin alpha2 and extracellular signal-regulated kinase are functionally linked in highly malignant autocrine transforming growth factor-alpha-driven colon cancer cells.
Author: Sawhney, Rajinder S|Sharma, Bhavya|Humphrey, Lisa E|Brattain, Michael G
PMID: 12657625
Journal: Oncogene. 2003 Apr 10;22(14):2186-91.
Title: Platelet-activating factor activates mitogen-activated protein kinases, inhibits proliferation, induces differentiation and suppresses the malignant phenotype of human colon carcinoma cells.
Author: Wang, Hongmei|Chakrabarty, Subhas
PMID: 12687020
Journal: J Cancer Res Clin Oncol. 2003 May;129(5):272-8. Epub 2003 May 14.
Title: Growth-promoting effect of muscarinic acetylcholine receptors in colon cancer cells.
Author: Ukegawa, J-I|Takeuchi, Y|Kusayanagi, S|Mitamura, K
PMID: 12748850
Journal: Biochim Biophys Acta. 2003 Jun 5;1653(1):25-40.
Title: Raf proteins and cancer: B-Raf is identified as a mutational target.
Author: Mercer, Kathryn E|Pritchard, Catrin A
PMID: 12781369
Journal: Mol Biol Cell. 2003 May;14(5):1790-800. Epub 2003 Jan 26.
Title: Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids.
Author: Bates, Richard C|Mercurio, Arthur M
PMID: 12802055
Journal: Am J Physiol Gastrointest Liver Physiol. 2003 Dec;285(6):G1181-8.
Title: The ERK pathway involves positive and negative regulations of HT-29 colorectal cancer cell growth by extracellular zinc.
Author: Park, Ki-Sook|Lee, Nam-Gu|Lee, Ki-Hoo|Seo, Jeong Taeg|Choi, Kang-Yell
PMID: 12816758
Journal: Carcinogenesis. 2003 Aug;24(8):1361-7.
Title: The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells.
Author: Hu, Rong|Kim, Bok Ryang|Chen, Chi|Hebbar, Vidya|Kong, A-N Tony
PMID: 12819185
Journal: Clin Cancer Res. 2003 Jul;9(7):2457-64.
Title: A pharmacodynamic study of the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in metastatic colorectal cancer patients.
Author: Daneshmand, Manijeh|Parolin, Doris A E|Hirte, Holger W|Major, Pierre|Goss, Glenwood|Stewart, David|Batist, Gerald|Miller, Wilson H Jr|Matthews, Sarah|Seymour, Lesley|Lorimer, Ian A J
PMID: 12855618
Journal: Br J Cancer. 2003 Jul 21;89(2):374-84.
Title: Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells.
Author: Ahmed, N|Oliva, K|Wang, Y|Quinn, M|Rice, G
PMID: 12865932
Journal: J Cell Physiol. 2003 Sep;196(3):454-63.
Title: Gastrin and EGF synergistically induce cyclooxygenase-2 expression in Swiss 3T3 fibroblasts that express the CCK2 receptor.
Author: Slice, Lee W|Hodikian, Raffi|Zhukova, Elena
PMID: 12891702
Journal: Cancer Cell. 2003 Jul;4(1):67-79.
Title: ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility.
Author: Vial, Emmanuel|Sahai, Erik|Marshall, Christopher J
PMID: 12892714
Journal: J Nutr. 2003 Nov;133(11 Suppl 1):3800S-3804S.
Title: The chemopreventive bioflavonoid apigenin modulates signal transduction pathways in keratinocyte and colon carcinoma cell lines.
Author: Van Dross, Rukiyah|Xue, Yue|Knudson, Alexandra|Pelling, Jill C
PMID: 14608117
Journal: J Cell Biol. 2003 Nov 24;163(4):847-57.
Title: Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK.
Author: Conacci-Sorrell, Maralice|Simcha, Inbal|Ben-Yedidia, Tamar|Blechman, Janna|Savagner, Pierre|Ben-Ze'ev, Avri
PMID: 14623871
Journal: J Cell Sci. 2003 Dec 15;116(Pt 24):4957-63.
Title: Elevated ERK-MAP kinase activity protects the FOS family member FRA-1 against proteasomal degradation in colon carcinoma cells.
Author: Vial, Emmanuel|Marshall, Christopher J
PMID: 14625389
Journal: Clin Chem. 2004 Mar;50(3):490-9. Epub 2004 Jan 15.
Title: Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers.
Author: Hafner, Christian|Schmitz, Gerd|Meyer, Stefanie|Bataille, Frauke|Hau, Peter|Langmann, Thomas|Dietmaier, Wolfgang|Landthaler, Michael|Vogt, Thomas
PMID: 14726470
Journal: Hum Mol Genet. 2004 Apr 1;13 Spec No 1:R103-21.
Title: The complex genetic epidemiology of prostate cancer.
Author: Schaid, Daniel J
PMID: 14749351
Journal: Cancer Biol Ther. 2004 Mar;3(3):296-301. Epub 2004 Mar 16.
Title: Lack of p38 MAP kinase activation in TRAIL-resistant cells is not related to the resistance to TRAIL-mediated cell death.
Author: Zhang, Lidong|Zhu, Hongbo|Davis, John J|Jacob, Dietmar|Wu, Shuhong|Teraishi, Fuminori|Gutierrez, Angelica|Wang, Yibin|Fang, Bingliang
PMID: 14749540
Journal: Cancer Res. 2004 Feb 1;64(3):781-8.
Title: EphB2 as a therapeutic antibody drug target for the treatment of colorectal cancer.
Author: Mao, Weiguang|Luis, Elizabeth|Ross, Sarajane|Silva, Johnny|Tan, Christine|Crowley, Craig|Chui, Clarissa|Franz, Gretchen|Senter, Peter|Koeppen, Hartmut|Polakis, Paul
PMID: 14871799
Journal: Oncogene. 2004 Mar 11;23(10):1885-95.
Title: Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-kappaB-dependent pathway.
Author: Wang, Xiaofu|Wang, Qingding|Hu, Wanqin|Evers, B Mark
PMID: 14981539
Journal: Oncogene. 2004 Jun 24;23(29):4984-92.
Title: Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl] amino]ethanol in correlation with activation of ERK.
Author: Zhu, Hongbo|Zhang, Lidong|Wu, Shuhong|Teraishi, Fuminori|Davis, John J|Jacob, Dietmar|Fang, Bingliang
PMID: 15122344
Journal: Cancer Res. 2004 May 15;64(10):3428-35.
Title: Different effects of point mutations within the B-Raf glycine-rich loop in colorectal tumors on mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase and nuclear factor kappaB pathway and cellular tra
Author: Ikenoue, Tsuneo|Hikiba, Yohko|Kanai, Fumihiko|Aragaki, Jun|Tanaka, Yasuo|Imamura, Jun|Imamura, Takaaki|Ohta, Miki|Ijichi, Hideaki|Tateishi, Keisuke|Kawakami, Takayuki|Matsumura, Masayuki|Kawabe, Takao|Omata, Masao
PMID: 15150094
Journal: Carcinogenesis. 2004 Nov;25(11):2183-9. Epub 2004 Jul 15.
Title: Curcumin induces c-jun N-terminal kinase-dependent apoptosis in HCT116 human colon cancer cells.
Author: Collett, Gavin P|Campbell, Frederick Charles
PMID: 15256484
Journal: J Biol Chem. 2004 Nov 5;279(45):47379-90. Epub 2004 Aug 10.
Title: Autocrine transforming growth factor alpha regulates cell adhesion by multiple signaling via specific phosphorylation sites of p70S6 kinase in colon cancer cells.
Author: Sawhney, Rajinder S|Cookson, Michelle M|Sharma, Bhavya|Hauser, Jennie|Brattain, Michael G
PMID: 15304500
Journal: Anticancer Res. 2004 Sep-Oct;24(5A):2885-91.
Title: EGF-receptor related protein causes cell cycle arrest and induces apoptosis of colon cancer cells in vitro and in vivo.
Author: Levi, Edi|Mohammad, Ramzi|Kodali, Udayini|Marciniak, Dorota|Reddy, Sudha|Aboukameel, Amro|Sarkar, Fazlul H|Kucuk, Omer|Rishi, Arun K|Majumdar, Adhip P N
PMID: 15517892
Journal: Cell Prolif. 2004 Dec;37(6):427-41.
Title: Extracellular pressure stimulates colon cancer cell proliferation via a mechanism requiring PKC and tyrosine kinase signals.
Author: Walsh, M F|Woo, R K-Y|Gomez, R|Basson, M D
PMID: 15548175
Journal: Cancer Res. 2004 Nov 15;64(22):8148-51.
Title: Inhibition of extracellular-signal regulated kinases 1/2 is required for apoptosis of human colon cancer cells in vitro by sulindac metabolites.
Author: Rice, Pamela L|Beard, K Scott|Driggers, Linda J|Ahnen, Dennis J
PMID: 15548677
Journal: Postepy Hig Med Dosw (Online). 2004;58:428-37.
Title: [Complex forms of immune insufficiency to some cytokines (TNF-alpha, interferons) in colorectal cancers as exemplified by the COLO 205 cell line. Mechanism of resistance with special reference to signaling proteins and cytokines].
Author: Pajak, Beata|Orzechowski, Arkadiusz
PMID: 15577750
Journal: Exp Mol Med. 2004 Dec 31;36(6):557-62.
Title: p21Cip/WAF1 activation is an important factor for the ERK pathway dependent anti-proliferation of colorectal cancer cells.
Author: Park, Ki Sook|Jeon, Soung Hoo|Oh, Jong Won|Choi, Kang Yell
PMID: 15665589
Journal: J Biol Chem. 2005 Feb 11;280(6):4544-52.
Title: The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1.
Author: Vlahakis, Nicholas E|Young, Bradford A|Atakilit, Amha|Sheppard, Dean
PMID: 15590642
Journal: Carcinogenesis. 2005 Mar;26(3):665-71. Epub 2004 Dec 23.
Title: Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cells.
Author: Nakamura, Yasushi|Chang, Chia-Cheng|Mori, Toshio|Sato, Kenji|Ohtsuki, Kozo|Upham, Brad L|Trosko, James E
PMID: 15618237
Journal: J Pharmacol Sci. 2005 Jan;97(1):25-30. Epub 2005 Jan 15.
Title: Physiology and pathophysiology of proteinase-activated receptors (PARs): PAR-2-mediated proliferation of colon cancer cell.
Author: Nishibori, Masahiro|Mori, Shuji|Takahashi, Hideo K
PMID: 15655297
Journal: Anticancer Drugs. 2005 Feb;16(2):129-36.
Title: The Raf kinase inhibitor BAY 43-9006 reduces cellular uptake of platinum compounds and cytotoxicity in human colorectal carcinoma cell lines.
Author: Heim, Martina|Scharifi, Mariam|Zisowsky, Jochen|Jaehde, Ulrich|Voliotis, Dimitris|Seeber, Siegfried|Strumberg, Dirk
PMID: 15655409
Journal: Br J Pharmacol. 2005 Feb;144(3):338-48.
Title: Gastrin promotes human colon cancer cell growth via CCK-2 receptor-mediated cyclooxygenase-2 induction and prostaglandin E2 production.
Author: Colucci, Rocchina|Blandizzi, Corrado|Tanini, Marzia|Vassalle, Cristina|Breschi, Maria Cristina|Del Tacca, Mario
PMID: 15655524
Journal: Mol Cancer Ther. 2005 Jan;4(1):51-9.
Title: Selective inhibitors of MEK1/ERK44/42 and p38 mitogen-activated protein kinases potentiate apoptosis induction by sulindac sulfide in human colon carcinoma cells.
Author: Sun, Yunjie|Sinicrope, Frank A
PMID: 15657353
Journal: Int J Cancer. 2005 Jul 10;115(5):673-7.
Title: Mutations of the BRAF gene in ulcerative colitis-related colorectal carcinoma.
Author: Aust, Daniela E|Haase, Michael|Dobryden, Lyudmyla|Markwarth, Annett|Lohrs, Udo|Wittekind, Christian|Baretton, Gustavo B|Tannapfel, Andrea
PMID: 15704157
Journal: Dig Dis Sci. 2005 Mar;50(3):490-8.
Title: Butyrate-induced differentiation of colon cancer cells is PKC and JNK dependent.
Author: Orchel, Arkadiusz|Dzierzewicz, Zofia|Parfiniewicz, Beata|Weglarz, Ludmila|Wilczok, Tadeusz
PMID: 15810631
Journal: J Cell Sci. 2005 Apr 15;118(Pt 8):1687-92.
Title: DCC association with lipid rafts is required for netrin-1-mediated axon guidance.
Author: Herincs, Zoltan|Corset, Veronique|Cahuzac, Nathalie|Furne, Celine|Castellani, Valerie|Hueber, Anne-Odile|Mehlen, Patrick
PMID: 15811950
Journal: J Biol Chem. 2005 Jun 24;280(25):23910-7. Epub 2005 Apr 25.
Title: Essential role of p38gamma in K-Ras transformation independent of phosphorylation.
Author: Tang, Jun|Qi, Xiaomei|Mercola, Dan|Han, Jiahuai|Chen, Guan
PMID: 15851477
Journal: Lancet Oncol. 2005 May;6(5):322-7.
Title: The MAPK signalling pathways and colorectal cancer.
Author: Fang, Jing Yuan|Richardson, Bruce C
PMID: 15863380
Journal: Cancer Res. 2005 May 1;65(9):3853-60.
Title: Supra-additive growth inhibition by a celecoxib analogue and carboxyamido-triazole is primarily mediated through apoptosis.
Author: Winters, Mary E|Mehta, Arpita I|Petricoin, Emanuel F 3rd|Kohn, Elise C|Liotta, Lance A
PMID: 15867384
Journal: World J Gastroenterol. 2005 May 28;11(20):3065-9.
Title: Ornithine decarboxylase, mitogen-activated protein kinase and matrix metalloproteinase-2 expressions in human colon tumors.
Author: Nemoto, Takahiro|Kubota, Shunichiro|Ishida, Hideyuki|Murata, Nobuo|Hashimoto, Daijo
PMID: 15918191
Journal: Exp Cell Res. 2005 Jul 1;307(1):231-46. Epub 2005 Apr 19.
Title: Smad7 induces tumorigenicity by blocking TGF-beta-induced growth inhibition and apoptosis.
Author: Halder, Sunil K|Beauchamp, R Daniel|Datta, Pran K
PMID: 15922743
Journal: Cells Tissues Organs. 2005;179(1-2):73-80.
Title: The SRC-induced mesenchymal state in late-stage colon cancer cells.
Author: Avizienyte, Egle|Brunton, Valerie G|Fincham, Valerie J|Frame, Margaret C
PMID: 15942195
Journal: Cancer Res. 2005 Jul 15;65(14):6275-81.
Title: Prostaglandin E2 activates mitogen-activated protein kinase/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner.
Author: Krysan, Kostyantyn|Reckamp, Karen L|Dalwadi, Harnisha|Sharma, Sherven|Rozengurt, Enrique|Dohadwala, Mariam|Dubinett, Steven M
PMID: 16024629
Journal: Clin Cancer Res. 2005 Jul 15;11(14):5181-7.
Title: EphB2 is a prognostic factor in colorectal cancer.
Author: Jubb, Adrian M|Zhong, Fiona|Bheddah, Sheila|Grabsch, Heike I|Frantz, Gretchen D|Mueller, Wolfram|Kavi, Vidya|Quirke, Phil|Polakis, Paul|Koeppen, Hartmut
PMID: 16033834
Journal: J Cell Biochem. 2005 Sep 1;96(1):155-69.
Title: Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells.
Author: Liao, Chiung-Ho|Sang, Shengmin|Ho, Chi-Tang|Lin, Jen-Kun
PMID: 16052481
Journal: Gastroenterology. 2005 Sep;129(3):952-68.
Title: Gastrin suppresses growth of CCK2 receptor expressing colon cancer cells by inducing apoptosis in vitro and in vivo.
Author: Muerkoster, Susanne|Isberner, Anett|Arlt, Alexander|Witt, Maike|Reimann, Babette|Blaszczuk, Ewelina|Werbing, Veronika|Folsch, Ulrich R|Schmitz, Frank|Schafer, Heiner
PMID: 16143134
Journal: Biochem Pharmacol. 2005 Oct 15;70(8):1147-57.
Title: Induction of apoptotic cell death by 2'-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-kappaB in TNF-alpha-treated SW620 colon cancer cells.
Author: Lee, Seung Ho|Lee, Chung Woo|Lee, Jae Woong|Choi, Myoung Suk|Son, Dong Ju|Chung, Youn Bok|Lee, Chong Kil|Oh, Ki Wan|Moon, Dong Chul|Kwon, Byoung Mog|Hong, Jin Tae
PMID: 16143316
Journal: Ai Zheng. 2005 Sep;24(9):1064-70.
Title: [Effect of NGX6 on gene expression profile of colon carcinoma cell line HT-29].
Author: Liu, Fen|Wang, Xiao-Yan|Lian, Ping|Xiao, Zhi-Ming|Shen, Shou-Rong|Ma, Jian|Xiong, Wei
PMID: 16159426
Journal: Clin Cancer Res. 2005 Sep 15;11(18):6450-8.
Title: EphB2 expression across 138 human tumor types in a tissue microarray: high levels of expression in gastrointestinal cancers.
Author: Lugli, Alessandro|Spichtin, Hanspeter|Maurer, Robert|Mirlacher, Martina|Kiefer, Jeff|Huusko, Pia|Azorsa, David|Terracciano, Luigi|Sauter, Guido|Kallioniemi, Olli-P|Mousses, Spyro|Tornillo, Luigi
PMID: 16166419
Journal: Cancer Res. 2005 Nov 15;65(22):10170-3.
Title: Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors.
Author: Alazzouzi, Hafid|Davalos, Veronica|Kokko, Antti|Domingo, Enric|Woerner, Stefan M|Wilson, Andrew J|Konrad, Lars|Laiho, Paivi|Espin, Eloi|Armengol, Manel|Imai, Kohzoh|Yamamoto, Hiroyuki|Mariadason, John M|Gebert, Johannes F|Aaltonen, Lauri A|Schwartz, Simo
PMID: 16288001
Journal: Cancer Res. 2005 Nov 15;65(22):10623-31.
Title: Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea.
Author: Ju, Jihyeung|Hong, Jungil|Zhou, Jian-nian|Pan, Zui|Bose, Mousumi|Liao, Jie|Yang, Guang-yu|Liu, Ying Ying|Hou, Zhe|Lin, Yong|Ma, Jianjie|Shih, Weichung Joe|Carothers, Adelaide M|Yang, Chung S
PMID: 16288056
Journal: Cancer Biol Ther. 2005 Oct;4(10):1159-67. Epub 2005 Oct 23.
Title: Chemotherapy regimen GOLF induces apoptosis in colon cancer cells through multi-chaperone complex inactivation and increased Raf-1 ubiquitin-dependent degradation.
Author: Caraglia, Michele|Marra, Monica|Budillon, Alfredo|Meo, Giuseppina|Ricciardiello, Filippo|Bismuto, Ettore|Brachelente, Giovanni|Francini, Guido|Giordano, Antonio|Correale, Pierpaolo|Abbruzzese, Alberto
PMID: 16294035
Journal: J Exp Ther Oncol. 2005;5(1):69-78.
Title: EGCG inhibits activation of HER3 and expression of cyclooxygenase-2 in human colon cancer cells.
Author: Shimizu, Masahito|Deguchi, Atsuko|Joe, Andrew K|Mckoy, Judith F|Moriwaki, Hisataka|Weinstein, I Bernard
PMID: 16416603
Journal: Regul Pept. 2006 Mar 15;134(1):1-8.
Title: Glycine-extended gastrin stimulates proliferation and inhibits apoptosis in colon cancer cells via cyclo-oxygenase-independent pathways.
Author: Ogunwobi, Olorunseun Olatunji|Beales, Ian L P
PMID: 16169610
Journal: Oncogene. 2006 Jan 12;25(2):278-87.
Title: Curcumin inhibits human colon cancer cell growth by suppressing gene expression of epidermal growth factor receptor through reducing the activity of the transcription factor Egr-1.
Author: Chen, A|Xu, J|Johnson, A C
PMID: 16170359
Journal: Cancer Chemother Pharmacol. 2006 Feb;57(3):317-27. Epub 2005 Sep 17.
Title: p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1.
Author: Shen, Guoxiang|Xu, Changjiang|Chen, Chi|Hebbar, Vidya|Kong, Ah-Ng Tony
PMID: 16170570
Journal: Int J Biochem Cell Biol. 2006 Feb;38(2):244-54.
Title: Molecular signaling cascade in DNA bisintercalator, echinomycin-induced apoptosis of HT-29 cells: evidence of the apoptotic process via activation of the cytochrome c-ERK-caspase-3 pathway.
Author: Park, Ju Youn|Ryang, Yong Suk|Shim, Kwang Yong|Lee, Jong In|Kim, Hong Sup|Kim, Yong Hae|Kim, Soo-Ki
PMID: 16214385
Journal: Biochem J. 2006 Mar 15;394(Pt 3):647-56.
Title: Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signalling.
Author: Kato, Kengo|Shiga, Kiyoto|Yamaguchi, Kazunori|Hata, Keiko|Kobayashi, Toshimitsu|Miyazaki, Kaoru|Saijo, Shigeru|Miyagi, Taeko
PMID: 16241905
Journal: Carcinogenesis. 2006 Mar;27(3):454-64. Epub 2005 Nov 4.
Title: Reduced expression of EphB2 that parallels invasion and metastasis in colorectal tumours.
Author: Guo, Dong Li|Zhang, Ji|Yuen, Siu Tsan|Tsui, Wai Yin|Chan, Annie S Y|Ho, Coral|Ji, Jiafu|Leung, Suet Yi|Chen, Xin
PMID: 16272170
Journal: J Biol Chem. 2006 Mar 31;281(13):8497-510. Epub 2006 Feb 3.
Title: Integrin alpha2-mediated ERK and calpain activation play a critical role in cell adhesion and motility via focal adhesion kinase signaling: identification of a novel signaling pathway.
Author: Sawhney, Rajinder S|Cookson, Michelle M|Omar, Yasin|Hauser, Jennie|Brattain, Michael G
PMID: 16461767
Journal: J Cell Sci. 2006 Mar 1;119(Pt 5):819-27. Epub 2006 Feb 14.
Title: APC inhibits ERK pathway activation and cellular proliferation induced by RAS.
Author: Park, Ki-Sook|Jeon, Soung Hoo|Kim, Sung-Eun|Bahk, Young-Yil|Holmen, Sheri L|Williams, Bart O|Chung, Kwang-Chul|Surh, Young-Joon|Choi, Kang-Yell
PMID: 16478791
Journal: Mol Cancer Ther. 2006 Feb;5(2):309-16.
Title: RRR-alpha-tocopherol succinate down-regulates oncogenic Ras signaling.
Author: Donapaty, Sreenivasa|Louis, Somaja|Horvath, Elizabeth|Kun, Jiang|Sebti, Said M|Malafa, Mokenge P
PMID: 16505104
Journal: Biochem Biophys Res Commun. 2006 Apr 28;343(1):8-14.
Title: Desferrioxamine, an iron chelator, enhances HIF-1alpha accumulation via cyclooxygenase-2 signaling pathway.
Author: Woo, Kyung Jin|Lee, Tae-Jin|Park, Jong-Wook|Kwon, Taeg Kyu
PMID: 16527254
Journal: Biochem Pharmacol. 2006 May 28;71(11):1540-50.
Title: The BH3-only protein, PUMA, is involved in oxaliplatin-induced apoptosis in colon cancer cells.
Author: Wang, Xinying|Li, Ming|Wang, Jide|Yeung, Chung-Man|Zhang, Hongquan|Kung, Hsiang-fu|Jiang, Bo|Lin, Marie Chia-mi
PMID: 16595125
Journal: Oncol Rep. 2006 May;15(5):1327-31.
Title: Effects of extracts from two Native American plants on proliferation of human breast and colon cancer cell lines in vitro.
Author: Daniels, Amber L|Van Slambrouck, Severine|Lee, Robin K|Arguello, Tammy S|Browning, James|Pullin, Michael J|Kornienko, Alexander|Steelant, Wim F A
PMID: 16596206
Journal: Carcinogenesis. 2006 Jul;27(7):1507-15. Epub 2006 Apr 5.
Title: Interleukin-6 production induced by leptin treatment promotes cell proliferation in an Apc (Min/+) colon epithelial cell line.
Author: Fenton, Jenifer I|Hursting, Stephen D|Perkins, Susan N|Hord, Norman G
PMID: 16597643
Journal: Oncogene. 2006 Sep 14;25(41):5640-7. Epub 2006 Apr 17.
Title: Proline oxidase activates both intrinsic and extrinsic pathways for apoptosis: the role of ROS/superoxides, NFAT and MEK/ERK signaling.
Author: Liu, Y|Borchert, G L|Surazynski, A|Hu, C-A|Phang, J M
PMID: 16619034
Journal: Carcinogenesis. 2006 Oct;27(10):1950-60.
Title: Arachidonic acid-induced gene expression in colon cancer cells.
Author: Monjazeb, Arta M|High, Kevin P|Connoy, Abbie|Hart, Lori S|Koumenis, Constantinos|Chilton, Floyd H
PMID: 16704987
Journal: Endocr Relat Cancer. 2006 Jun;13(2):571-81.
Title: Folic acid and its metabolites modulate IGF-I receptor gene expression in colon cancer cells in a p53-dependent manner.
Author: Attias, Z|Werner, H|Vaisman, N
PMID: 16728583
Journal: BMC Cancer. 2006 Jun 1;6:145.
Title: EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis.
Author: Kokko, Antti|Laiho, Paivi|Lehtonen, Rainer|Korja, Sanna|Carvajal-Carmona, Luis G|Jarvinen, Heikki|Mecklin, Jukka-Pekka|Eng, Charis|Schleutker, Johanna|Tomlinson, Ian P M|Vahteristo, Pia|Aaltonen, Lauri A
PMID: 16740153
Journal: Cell Stress Chaperones. 2006 Summer;11(2):135-47.
Title: Stress-induced phosphorylation of caveolin-1 and p38, and down-regulation of EGFr and ERK by the dietary lectin jacalin in two human carcinoma cell lines.
Author: Sahasrabuddhe, Anagh A|Ahmed, Neesar|Krishnasastry, M V
PMID: 16817319
Journal: Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14122-7. Epub 2006 Sep 7.
Title: Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo.
Author: Sansom, Owen J|Meniel, Valerie|Wilkins, Julie A|Cole, Alicia M|Oien, Karin A|Marsh, Victoria|Jamieson, Thomas J|Guerra, Carmen|Ashton, Gabrielle H|Barbacid, Mariano|Clarke, Alan R
PMID: 16959882
Journal: FEBS Lett. 2006 Dec 11;580(28-29):6565-9.
Title: Different modulation of TRAIL-induced apoptosis by inhibition of pro-survival pathways in TRAIL-sensitive and TRAIL-resistant colon cancer cells.
Author: Vaculova, Alena|Hofmanova, Jirina|Soucek, Karel|Kozubik, Alois
PMID: 17113582
Journal: Oncogene. 2007 Jan 11;26(2):308-11. Epub 2006 Jul 3.
Title: High EPHB2 mutation rate in gastric but not endometrial tumors with microsatellite instability.
Author: Davalos, V|Dopeso, H|Velho, S|Ferreira, A M|Cirnes, L|Diaz-Chico, N|Bilbao, C|Ramirez, R|Rodriguez, G|Falcon, O|Leon, L|Niessen, R C|Keller, G|Dallenbach-Hellweg, G|Espin, E|Armengol, M|Plaja, A|Perucho, M|Imai, K|Yamamoto, H|Gebert, J F|Diaz-Chico, J C|H
PMID: 16819508
Journal: Cell Signal. 2007 Feb;19(2):261-8. Epub 2006 Aug 9.
Title: MAGI-3 regulates LPA-induced activation of Erk and RhoA.
Author: Zhang, Huanchun|Wang, Dongsheng|Sun, Hong|Hall, Randy A|Yun, C Chris
PMID: 16904289
Journal: Cancer Chemother Pharmacol. 2007 Apr;59(5):651-9. Epub 2006 Aug 26.
Title: Antitumor activity of HER1/EGFR tyrosine kinase inhibitor erlotinib, alone and in combination with CPT-11 (irinotecan) in human colorectal cancer xenograft models.
Author: Chen, Jianping|Smith, Melissa|Kolinsky, Kenneth|Adames, Violeta|Mehta, Nila|Fritzky, Luke|Rashed, Mohammad|Wheeldon, Eric|Linn, Michael|Higgins, Brian
PMID: 16937104
Journal: J Nutr Biochem. 2007 May;18(5):332-40.
Title: Conjugated linoleic acid inhibits Caco-2 cell growth via ERK-MAPK signaling pathway.
Author: Bocca, Claudia|Bozzo, Francesca|Gabriel, Ludovica|Miglietta, Antonella
PMID: 16963252
Journal: Gynecol Oncol. 2007 Feb;104(2):461-9. Epub 2006 Oct 9.
Title: L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells.
Author: Stoeck, Alexander|Gast, Daniela|Sanderson, Michael P|Issa, Yasmin|Gutwein, Paul|Altevogt, Peter
PMID: 17030349
Journal: Biochem Pharmacol. 2007 Jan 1;73(1):68-76. Epub 2006 Sep 19.
Title: Elevated gadd153/chop expression during resveratrol-induced apoptosis in human colon cancer cells.
Author: Woo, Kyung Jin|Lee, Tae Jin|Lee, Sang Han|Lee, Jin-Man|Seo, Ji-Hyung|Jeong, Yong-Jin|Park, Jong-Wook|Kwon, Taeg Kyu
PMID: 17049495
Journal: Exp Cell Res. 2007 Feb 15;313(4):719-31. Epub 2006 Nov 18.
Title: RhoE interferes with Rb inactivation and regulates the proliferation and survival of the U87 human glioblastoma cell line.
Author: Poch, Enric|Minambres, Rebeca|Mocholi, Enric|Ivorra, Carmen|Perez-Arago, Amparo|Guerri, Consuelo|Perez-Roger, Ignacio|Guasch, Rosa M
PMID: 17182035
Journal: Cancer Lett. 2007 Jun 28;251(2):237-46. Epub 2006 Dec 26.
Title: Anti-EGFR and ErbB-2 antibodies attenuate cyclooxygenase-2 expression and cooperatively inhibit survival of human colon cancer cells.
Author: Half, Elizabeth|Sun, Yunjie|Sinicrope, Frank A
PMID: 17189670
Journal: Histopathology. 2007 Jan;50(1):131-50.
Title: Colorectal serrated adenocarcinoma.
Author: Makinen, M J
PMID: 17204027
Journal: J Cell Biochem. 2007 Aug 1;101(5):1165-75.
Title: NF-kappaB pathway is involved in griseofulvin-induced G2/M arrest and apoptosis in HL-60 cells.
Author: Uen, Yih-Huei|Liu, Der-Zen|Weng, Meng-Shih|Ho, Yuan-Soon|Lin, Shyr-Yi
PMID: 17226769
Journal: Cancer Res. 2007 Jan 15;67(2):665-73.
Title: A novel mechanism of resistance to epidermal growth factor receptor antagonism in vivo.
Author: Rajput, Ashwani|Koterba, Alan P|Kreisberg, Jeffrey I|Foster, Jason M|Willson, James K V|Brattain, Michael G
PMID: 17234777
Journal: J Biol Chem. 2007 Apr 20;282(16):12249-59. Epub 2007 Feb 16.
Title: Inhibition of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway decreases DNA methylation in colon cancer cells.
Author: Lu, Rong|Wang, Xia|Chen, Zhao-Fei|Sun, Dan-Feng|Tian, Xiao-Qing|Fang, Jing-Yuan
PMID: 17307743
Journal: Cancer Biol Ther. 2007 Mar;6(3):367-76. Epub 2007 Mar 13.
Title: Basic transcription factor 3 (BTF3) regulates transcription of tumor-associated genes in pancreatic cancer cells.
Author: Kusumawidjaja, Grace|Kayed, Hany|Giese, Nathalia|Bauer, Andrea|Erkan, Mert|Giese, Thomas|Hoheise, Jorg D|Friess, Helmut|Kleeff, Jorg
PMID: 17312387
Journal: Cell Signal. 2007 Jul;19(7):1465-72. Epub 2007 Jan 24.
Title: BMP-induced growth suppression in colon cancer cells is mediated by p21WAF1 stabilization and modulated by RAS/ERK.
Author: Beck, Stayce E|Jung, Barbara H|Del Rosario, Eunice|Gomez, Jessica|Carethers, John M
PMID: 17317101
Journal: Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1511-9.
Title: Decreased MAPK- and PGE2-dependent IL-11 production in Gialpha2-/- colonic myofibroblasts.
Author: Hoang, Brian|Trinh, Alice|Birnbaumer, Lutz|Edwards, Robert A
PMID: 17332478
Journal: Cancer Biol Ther. 2007 Apr;6(4):494-503.
Title: Profiling of selenomethionine responsive genes in colon cancer by microarray analysis.
Author: Goulet, Anne-Christine|Watts, George|Lord, Jean L|Nelson, Mark A
PMID: 17374985
Journal: Endocr Relat Cancer. 2007 Mar;14(1):141-51.
Title: The inhibition of Wnt/beta-catenin signalling by 1alpha,25-dihydroxyvitamin D3 is abrogated by Snail1 in human colon cancer cells.
Author: Larriba, Maria Jesus|Valle, Noelia|Palmer, Hector G|Ordonez-Moran, Paloma|Alvarez-Diaz, Silvia|Becker, Karl-Friedrich|Gamallo, Carlos|de Herreros, Antonio Garcia|Gonzalez-Sancho, Jose Manuel|Munoz, Alberto
PMID: 17395983
Journal: Dig Dis Sci. 2007 Aug;52(8):1934-45.
Title: Cyclo-oxygenase-independent inhibition of apoptosis and stimulation of proliferation by leptin in human colon cancer cells.
Author: Ogunwobi, Olorunseun Olatunji|Beales, Ian L P
PMID: 17406816
Journal: Cell Signal. 2007 Aug;19(8):1722-32. Epub 2007 Mar 28.
Title: Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells.
Author: Grijelmo, Clara|Rodrigue, Christelle|Svrcek, Magalie|Bruyneel, Erik|Hendrix, An|de Wever, Olivier|Gespach, Christian
PMID: 17478078
Journal: Chin Med J (Engl). 2007 May 5;120(9):743-8.
Title: Inducing effects of hepatocyte growth factor on the expression of vascular endothelial growth factor in human colorectal carcinoma cells through MEK and PI3K signaling pathways.
Author: Zhang, Yu-hua|Wei, Wei|Xu, Hao|Wang, Yan-yan|Wu, Wen-xi
PMID: 17531111
Journal: Biochim Biophys Acta. 2007 Aug;1770(8):1194-203. Epub 2007 May 3.
Title: Lysophosphatidic acid prevents apoptosis of Caco-2 colon cancer cells via activation of mitogen-activated protein kinase and phosphorylation of Bad.
Author: Rusovici, Raluca|Ghaleb, Amr|Shim, Hyunsuk|Yang, Vincent W|Yun, C Chris
PMID: 17544220
Journal: Int J Cancer. 2007 Nov 15;121(10):2172-80.
Title: The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells.
Author: Greenhough, Alexander|Patsos, Helena A|Williams, Ann C|Paraskeva, Christos
PMID: 17583570
Journal: Dis Colon Rectum. 2007 Aug;50(8):1230-40.
Title: RAGE activation by S100P in colon cancer stimulates growth, migration, and cell signaling pathways.
Author: Fuentes, Maren K|Nigavekar, Shraddha S|Arumugam, Thiruvengadam|Logsdon, Craig D|Schmidt, Ann Marie|Park, Juliet C|Huang, Emina H
PMID: 17587138
Journal: Exp Cell Res. 2007 Aug 15;313(14):2969-79.
Title: The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells.
Author: Cherukuri, Durga Prasad|Chen, Xiao B O|Goulet, Anne-Christine|Young, Robert N|Han, Yongxin|Heimark, Ronald L|Regan, John W|Meuillet, Emmanuelle|Nelson, Mark A
PMID: 17631291
Journal: Am J Physiol Gastrointest Liver Physiol. 2007 Oct;293(4):G719-28. Epub 2007 Jul
Title: HETEs enhance IL-1-mediated COX-2 expression via augmentation of message stability in human colonic myofibroblasts.
Author: Di Mari, J F|Saada, J I|Mifflin, R C|Valentich, J D|Powell, D W
PMID: 17640979
Journal: Zhonghua Yi Xue Za Zhi. 2007 Apr 10;87(14):982-6.
Title: [Effects of extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway activation on proliferation and cell cycle associated genes in human colon cancer cells].
Author: Wang, Xia|Lu, Rong|Fang, Jing-yuan
PMID: 17650425
Journal: Cancer Res. 2007 Aug 1;67(15):7106-12.
Title: Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer.
Author: Ma, Li|Teruya-Feldstein, Julie|Bonner, Pauline|Bernardi, Rosa|Franz, David Neal|Witte, David|Cordon-Cardo, Carlos|Pandolfi, Pier Paolo
PMID: 17671177
Journal: Cancer Res. 2007 Aug 1;67(15):7266-74.
Title: Antiapoptotic effects of progastrin on pancreatic cancer cells are mediated by sustained activation of nuclear factor-{kappa}B.
Author: Rengifo-Cam, William|Umar, Shahid|Sarkar, Shubhashish|Singh, Pomila
PMID: 17671195
Journal: Exp Mol Pathol. 2007 Dec;83(3):443-52.
Title: Keratinocyte growth factor-transfection-stimulated adhesion of colorectal cancer cells to extracellular matrices.
Author: Kudo, Mitsuhiro|Ishiwata, Toshiyuki|Nakazawa, Nando|Kawahara, Kiyoko|Fujii, Takenori|Teduka, Kiyoshi|Naito, Zenya
PMID: 17706640
Journal: Surgery. 2007 Sep;142(3):384-92.
Title: Thermal sensitization through ROS modulation: a strategy to improve the efficacy of hyperthermic intraperitoneal chemotherapy.
Author: Wang, Chia-Chi|Chen, Fei|Kim, Eugene|Harrison, Lawrence E
PMID: 17723891
Journal: J Med Chem. 2007 Oct 18;50(21):5090-102.
Title: 4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.
Author: Spicer, Julie A|Rewcastle, Gordon W|Kaufman, Michael D|Black, Shannon L|Plummer, Mark S|Denny, William A|Quin, John 3rd|Shahripour, Aurash B|Barrett, Stephen D|Whitehead, Christopher E|Milbank, Jared B J|Ohren, Jeffrey F|Gowan, Richard C|Omer, Charles|Cam
PMID: 17880056
Journal: J Pathol. 2007 Nov;213(3):257-65.
Title: Microsatellite unstable colorectal cancer cell lines with truncating TGFbetaRII mutations remain sensitive to endogenous TGFbeta.
Author: Baker, K|Raut, P|Jass, J R
PMID: 17893910
Journal: Nat Genet. 2007 Nov;39(11):1376-83. Epub 2007 Sep 30.
Title: EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells.
Author: Cortina, Carme|Palomo-Ponce, Sergio|Iglesias, Mar|Fernandez-Masip, Juan Luis|Vivancos, Ana|Whissell, Gavin|Huma, Mireia|Peiro, Nerea|Gallego, Lourdes|Jonkheer, Suzanne|Davy, Alice|Lloreta, Josep|Sancho, Elena|Batlle, Eduard
PMID: 17906625
Journal: Cancer Res. 2007 Oct 1;67(19):9286-93.
Title: Nitric oxide inactivates the retinoblastoma pathway in chronic inflammation.
Author: Ying, Lei|Hofseth, Anne B|Browning, Darren D|Nagarkatti, Mitzi|Nagarkatti, Prakash S|Hofseth, Lorne J
PMID: 17909036
Journal: Beijing Da Xue Xue Bao. 2007 Oct 18;39(5):453-7.
Title: [Regulation of promatrilysin expression by tissue factor/actived coagulation factor VII complex in LoVo colon cancer cell line].
Author: Tang, Jian-qiang|Wan, Yuan-lian|Liu, Yu-cun|Rong, Long|Wang, Xin|Wu, Tao|Pan, Yi-sheng|Zhu, Jing
PMID: 17940558
Journal: Cancer Biol Ther. 2007 Aug;6(8):1313-7.
Title: BMP suppresses PTEN expression via RAS/ERK signaling.
Author: Beck, Stayce E|Carethers, John M
PMID: 18059158
Journal: Cell Cycle. 2007 Dec 15;6(24):3078-85.
Title: Bilirubin inhibits tumor cell growth via activation of ERK.
Author: Ollinger, Robert|Kogler, Pamela|Troppmair, Jakob|Hermann, Martin|Wurm, Martin|Drasche, Astrid|Konigsrainer, Ingmar|Amberger, Albert|Weiss, Helmut|Ofner, Dietmar|Bach, Fritz H|Margreiter, Raimund
PMID: 18073533
Journal: Epigenetics. 2007 Oct-Dec;2(4):237-43. Epub 2007 Dec 9.
Title: The EPH receptor Bs (EPHBs) promoters are unmethylated in colon and ovarian cancers.
Author: Wu, Qinghua|Lind, Guro E|Aasheim, Hans-Christian|Micci, Francesca|Silins, Ilvars|Trope, Claes G|Nesland, Jahn M|Lothe, Ragnhild A|Suo, Zhenhe
PMID: 18281782
Journal: Oncology. 2007;73(1-2):98-103.
Title: Proteasome inhibition potentiates the cytotoxic effects of hyperthermia in HT-29 colon cancer cells through inhibition of heat shock protein 27.
Author: Chen, Fei|Rezavi, Reza|Wang, Cha-Chi|Harrison, Lawrence E
PMID: 18337621
Journal: Rev Recent Clin Trials. 2007 May;2(2):121-34.
Title: Therapeutic strategies for targeting BRAF in human cancer.
Author: Pratilas, Christine A|Solit, David B
PMID: 18473997
Journal: Oncogene. 2008 Jan 3;27(1):85-97. Epub 2007 Jun 25.
Title: Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models.
Author: Desnoyers, L R|Pai, R|Ferrando, R E|Hotzel, K|Le, T|Ross, J|Carano, R|D'Souza, A|Qing, J|Mohtashemi, I|Ashkenazi, A|French, D M
PMID: 17599042
Journal: Pharm Res. 2008 Feb;25(2):387-99. Epub 2007 Jul 27.
Title: Synergistic effects of a combination of dietary factors sulforaphane and (-) epigallocatechin-3-gallate in HT-29 AP-1 human colon carcinoma cells.
Author: Nair, Sujit|Hebbar, Vidya|Shen, Guoxiang|Gopalakrishnan, Avantika|Khor, Tin Oo|Yu, Siwang|Xu, Changjiang|Kong, Ah-Ng
PMID: 17657594
Journal: J Cell Biochem. 2008 May 1;104(1):259-73.
Title: Regulation of apoptosis by modified naringenin derivatives in human colorectal carcinoma RKO cells.
Author: Lee, Eung-Ryoung|Kang, Yong-Jin|Kim, Hyun-Jeong|Choi, Hye-Yeon|Kang, Geun-Ho|Kim, Jung-Hyun|Kim, Bong-Woo|Jeong, Hyo-Soon|Park, Yong-Sun|Cho, Ssang-Goo
PMID: 18004724
Journal: Am J Physiol Gastrointest Liver Physiol. 2008 Mar;294(3):G599-609.
Title: Saccharomyces boulardii interferes with Shigella pathogenesis by postinvasion signaling events.
Author: Mumy, Karen L|Chen, Xinhua|Kelly, Ciaran P|McCormick, Beth A
PMID: 18032477
Journal: Toxicol Appl Pharmacol. 2008 Feb 15;227(1):136-46.
Title: Polymeric black tea polyphenols inhibit 1,2-dimethylhydrazine induced colorectal carcinogenesis by inhibiting cell proliferation via Wnt/beta-catenin pathway.
Author: Patel, Rachana|Ingle, Arvind|Maru, Girish B
PMID: 18037152
Journal: J Biol Chem. 2008 Feb 15;283(7):4094-104. Epub 2007 Dec 15.
Title: Phorbol ester up-regulates phospholipase D1 but not phospholipase D2 expression through a PKC/Ras/ERK/NFkappaB-dependent pathway and enhances matrix metalloproteinase-9 secretion in colon cancer cells.
Author: Kang, Dong Woo|Park, Mi Hee|Lee, Young Jun|Kim, Hyung Sik|Kwon, Taeg Kyu|Park, Won-Sang|Min, Do Sik
PMID: 18084005
Journal: J Biol Chem. 2008 Feb 22;283(8):5023-33. Epub 2007 Dec 17.
Title: Suppression of v-Src transformation by andrographolide via degradation of the v-Src protein and attenuation of the Erk signaling pathway.
Author: Liang, Fong-Pin|Lin, Chao-Hsiung|Kuo, Cheng-Deng|Chao, Hsueh-Ping|Fu, Shu-Ling
PMID: 18086662
Journal: Biol Pharm Bull. 2008 Jan;31(1):79-84.
Title: Comparative examination of anti-proliferative activities of (-)-epigallocatechin gallate and (--)-epigallocatechin against HCT116 colorectal carcinoma cells.
Author: Inaba, Hiroyuki|Nagaoka, Yasuo|Kushima, Yukihiro|Kumagai, Ayako|Matsumoto, Yoshinori|Sakaguchi, Minoru|Baba, Kimiye|Uesato, Shinichi
PMID: 18175946
Journal: Int J Cancer. 2008 Jun 1;122(11):2462-70.
Title: Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon.
Author: Calcagno, Shelly R|Li, Shuhua|Colon, Migdalisel|Kreinest, Pamela A|Thompson, E Aubrey|Fields, Alan P|Murray, Nicole R
PMID: 18271008
Journal: J Biol Chem. 2008 Apr 25;283(17):11565-74.
Title: A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization.
Author: Wang, Chunmei|Li, Nan|Liu, Xingguang|Zheng, Yuanyuan|Cao, Xuetao
PMID: 18305109
Journal: Cancer Biol Ther. 2008 Jun;7(6):902-8. Epub 2008 Mar 17.
Title: The BH3-only protein PUMA is involved in green tea polyphenol-induced apoptosis in colorectal cancer cell lines.
Author: Wang, Xi|Wang, Rui|Hao, Miao-Wang|Dong, Ke|Wei, San-Hua|Lin, Fang|Ren, Ji-Hong|Zhang, Hui-Zhong
PMID: 18367875
Journal: Curr Med Chem. 2008;15(10):978-90.
Title: ANTI-ADHESION evolves to a promising therapeutic concept in oncology.
Author: Schmidmaier, R|Baumann, P
PMID: 18393855
Journal: Oncogene. 2008 Aug 21;27(36):4921-32.
Title: Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6.
Author: Adachi, Y|Shibai, Y|Mitsushita, J|Shang, W H|Hirose, K|Kamata, T
PMID: 18454176
Journal: Biol Pharm Bull. 2008 Jun;31(6):1177-81.
Title: Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells.
Author: Nagaoka, Yasuo|Otsuki, Kota|Fujita, Tetsuro|Uesato, Shinichi
PMID: 18520051
Journal: Oncol Rep. 2008 Jul;20(1):3-11.
Title: Analysis of the K-ras/B-raf/Erk signal cascade, p53 and CMAP as markers for tumor progression in colorectal cancer patients.
Author: Georgieva, Milka|Krasteva, Maria|Angelova, Elka|Ralchev, Krassimir|Dimitrov, Valentin|Bozhimirov, Stanislav|Georgieva, Elena|Berger, Martin R
PMID: 18575712
Journal: J Biol Chem. 2008 Oct 10;283(41):27612-9.
Title: Alpha2beta1 integrin regulates lineage commitment in multipotent human colorectal cancer cells.
Author: Kirkland, Susan C|Ying, Huijun
PMID: 18664572
Journal: PLoS One. 2008 Aug 6;3(8):e2885.
Title: Germline EPHB2 receptor variants in familial colorectal cancer.
Author: Zogopoulos, George|Jorgensen, Claus|Bacani, Julinor|Montpetit, Alexandre|Lepage, Pierre|Ferretti, Vincent|Chad, Lauren|Selvarajah, Subani|Zanke, Brent|Hudson, Thomas J|Pawson, Tony|Gallinger, Steven
PMID: 18682749
Journal: Int J Oncol. 2008 Sep;33(3):573-7.
Title: Overexpression of EphA4 gene and reduced expression of EphB2 gene correlates with liver metastasis in colorectal cancer.
Author: Oshima, Takashi|Akaike, Makoto|Yoshihara, Kazue|Shiozawa, Manabu|Yamamoto, Naoto|Sato, Tsutomu|Akihito, Nozaki|Nagano, Yasuhiko|Fujii, Shoich|Kunisaki, Chikara|Wada, Nobuyuki|Rino, Yasushi|Tanaka, Katsuaki|Masuda, Munetaka|Imada, Toshio
PMID: 18695888
Journal: Biochem Biophys Res Commun. 2008 Dec 12;377(2):622-6.
Title: PAR2 triggers IL-8 release via MEK/ERK and PI3-kinase/Akt pathways in GI epithelial cells.
Author: Tanaka, Yusuke|Sekiguchi, Fumiko|Hong, Hao|Kawabata, Atsufumi
PMID: 18854173
Journal: Cell Commun Signal. 2008 Oct 24;6:8.
Title: Gamma-secretase inhibition combined with platinum compounds enhances cell death in a large subset of colorectal cancer cells.
Author: Aleksic, Tamara|Feller, Stephan M
PMID: 18950493
Journal: Br J Cancer. 2008 Nov 18;99(10):1712-7.
Title: Two-marker protein profile predicts poor prognosis in patients with early rectal cancer.
Author: Zlobec, I|Baker, K|Terracciano, L|Peter, S|Degen, L|Beglinger, C|Lugli, A
PMID: 18985041
Journal: Int J Cancer. 2009 Apr 1;124(7):1517-25.
Title: Aberrant expression of proteinase-activated receptor 4 promotes colon cancer cell proliferation through a persistent signaling that involves Src and ErbB-2 kinase.
Author: Gratio, Valerie|Walker, Francine|Lehy, Therese|Laburthe, Marc|Darmoul, Dalila
PMID: 19058300
Journal: Brain Res. 2009 Feb 23;1256:85-91.
Title: Intra-hippocampal administration of the VEGF receptor blocker PTK787/ZK222584 impairs long-term memory.
Author: Pati, Shibani|Orsi, Sara A|Moore, Anthony N|Dash, Pramod K
PMID: 19100245
Journal: Diabetes Metab Res Rev. 2009 Jan;25(1):41-9.
Title: Insulin analogues display IGF-I-like mitogenic and anti-apoptotic activities in cultured cancer cells.
Author: Weinstein, Doron|Simon, Meital|Yehezkel, Einat|Laron, Zvi|Werner, Haim
PMID: 19145584
Journal: Int J Mol Med. 2009 Feb;23(2):189-96.
Title: Astragalus saponins induce apoptosis via an ERK-independent NF-kappaB signaling pathway in the human hepatocellular HepG2 cell line.
Author: Auyeung, Kathy Ka-wai|Law, Pui-ching|Ko, Joshua Ka-shun
PMID: 19148542
Journal: Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2835-40.
Title: Knockin of mutant PIK3CA activates multiple oncogenic pathways.
Author: Gustin, John P|Karakas, Bedri|Weiss, Michele B|Abukhdeir, Abde M|Lauring, Josh|Garay, Joseph P|Cosgrove, David|Tamaki, Akina|Konishi, Hiroyuki|Konishi, Yuko|Mohseni, Morassa|Wang, Grace|Rosen, D Marc|Denmeade, Samuel R|Higgins, Michaela J|Vitolo, Michele
PMID: 19196980
Journal: Am J Physiol Renal Physiol. 2009 Apr;296(4):F723-9.
Title: Netrin-1 increases proliferation and migration of renal proximal tubular epithelial cells via the UNC5B receptor.
Author: Wang, Weiwei|Reeves, W Brian|Ramesh, Ganesan
PMID: 19211685
Journal: Cancer Sci. 2009 Apr;100(4):588-94.
Title: Plasma membrane-associated sialidase (NEU3) promotes formation of colonic aberrant crypt foci in azoxymethane-treated transgenic mice.
Author: Shiozaki, Kazuhiro|Yamaguchi, Kazunori|Sato, Ikuro|Miyagi, Taeko
PMID: 19215228
Journal: Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4):G755-63.
Title: Acetylcholine-induced activation of M3 muscarinic receptors stimulates robust matrix metalloproteinase gene expression in human colon cancer cells.
Author: Xie, Guofeng|Cheng, Kunrong|Shant, Jasleen|Raufman, Jean-Pierre
PMID: 19221016
Journal: Biochem Biophys Res Commun. 2009 May 1;382(2):451-6.
Title: Inhibition of macroautophagy by bafilomycin A1 lowers proliferation and induces apoptosis in colon cancer cells.
Author: Wu, Ya Chun|Wu, William Ka Kei|Li, Youming|Yu, Le|Li, Zhi Jie|Wong, Clover Ching Man|Li, Hai Tao|Sung, Joseph Jao Yiu|Cho, Chi Hin
PMID: 19289106
Journal: Cell Cycle. 2009 Apr 15;8(8):1228-37. Epub 2009 Apr 23.
Title: A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration.
Author: Ierano, Caterina|Giuliano, Paola|D'Alterio, Crescenzo|Cioffi, Michele|Mettivier, Valentina|Portella, Luigi|Napolitano, Maria|Barbieri, Antonio|Arra, Claudio|Liguori, Giuseppina|Franco, Renato|Palmieri, Giuseppe|Rozzo, Carla|Pacelli, Roberto|Castello, Gius
PMID: 19305148
Journal: Cancer Lett. 2009 Aug 28;281(2):162-70.
Title: Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells.
Author: Xavier, Cristina P R|Lima, Cristovao F|Preto, Ana|Seruca, Raquel|Fernandes-Ferreira, Manuel|Pereira-Wilson, Cristina
PMID: 19344998
Journal: Cancer Res. 2009 May 1;69(9):3736-45.
Title: Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progression.
Author: Kumar, S Ram|Scehnet, Jeffrey S|Ley, Eric J|Singh, Jasbir|Krasnoperov, Valery|Liu, Ren|Manchanda, Parmeet K|Ladner, Robert D|Hawes, Debra|Weaver, Fred A|Beart, Robert W|Singh, Gagandeep|Nguyen, Cu|Kahn, Michael|Gill, Parkash S
PMID: 19366806
Journal: Mutat Res. 2009 Jul-Aug;682(1):39-53.
Title: Mechanisms of primary cancer prevention by butyrate and other products formed during gut flora-mediated fermentation of dietary fibre.
Author: Scharlau, Daniel|Borowicki, Anke|Habermann, Nina|Hofmann, Thomas|Klenow, Stefanie|Miene, Claudia|Munjal, Umang|Stein, Katrin|Glei, Michael
PMID: 19383551
Journal: Int J Cancer. 2009 Sep 1;125(5):1082-91.
Title: A novel anticancer effect of Astragalus saponins: Transcriptional activation of NSAID-activated gene.
Author: Auyeung, Kathy K W|Cho, Chi-Hin|Ko, Joshua K S
PMID: 19384947
Journal: J Pathol. 2009 Aug;218(4):514-9.
Title: Quantitative cell signalling analysis reveals down-regulation of MAPK pathway activation in colorectal cancer.
Author: Gulmann, Christian|Sheehan, Katherine M|Conroy, Ronan M|Wulfkuhle, Julia D|Espina, Virginia|Mullarkey, Michelle J|Kay, Elaine W|Liotta, Lance A|Petricoin, Emanuel F 3rd
PMID: 19396842
Journal: IUBMB Life. 2009 Jun;61(6):685-92.
Title: Tax1 enhances cancer cell proliferation via Ras-Raf-MEK-ERK signaling pathway.
Author: Song, Chunjiao|Wang, Weimin|Li, Meng|Liu, Yanxin|Zheng, Dexian
PMID: 19472191
Journal: Arch Physiol Biochem. 2009 Jul;115(3):127-36.
Title: Effects of omega-3 and omega-6 fatty acids on IGF-I receptor signalling in colorectal cancer cells.
Author: Seti, Hila|Leikin-Frenkel, Alicia|Werner, Haim
PMID: 19480565
Journal: Arch Biochem Biophys. 2009 Jul 15;487(2):139-45.
Title: 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is up-regulated by flurbiprofen and other non-steroidal anti-inflammatory drugs in human colon cancer HT29 cells.
Author: Chi, Xiuling|Freeman, Brittany Morgan|Tong, Min|Zhao, Yuhua|Tai, Hsin-Hsiung
PMID: 19501039
Journal: Clin Cancer Res. 2009 Jun 15;15(12):4046-57.
Title: CUDC-305, a novel synthetic HSP90 inhibitor with unique pharmacologic properties for cancer therapy.
Author: Bao, Rudi|Lai, Cheng-Jung|Qu, Hui|Wang, Dagong|Yin, Ling|Zifcak, Brian|Atoyan, Ruzanna|Wang, Jing|Samson, Maria|Forrester, Jeffrey|DellaRocca, Steven|Xu, Guang-Xin|Tao, Xu|Zhai, Hai-Xiao|Cai, Xiong|Qian, Changgeng
PMID: 19509149
Journal: Biochem Pharmacol. 2009 Nov 1;78(9):1205-13.
Title: Macrophage inhibitory cytokine-1 (MIC-1) and subsequent urokinase-type plasminogen activator mediate cell death responses by ribotoxic anisomycin in HCT-116 colon cancer cells.
Author: Yang, Hyun|Choi, Hye Jin|Park, Seong Hwan|Kim, Jong Sik|Moon, Yuseok
PMID: 19540205
Journal: Biochem Biophys Res Commun. 2009 Sep 25;387(3):521-4.
Title: Carbachol induces p70S6K1 activation through an ERK-dependent but Akt-independent pathway in human colonic epithelial cells.
Author: Jiang, Xiaohua|Sinnett-Smith, James|Rozengurt, Enrique
PMID: 19615971
Journal: J Pathol. 2009 Sep;219(1):103-13.
Title: c-Rel is a transcriptional repressor of EPHB2 in colorectal cancer.
Author: Fu, Tao|Li, Peng|Wang, Hanzhi|He, Yujun|Luo, Donglin|Zhang, Anping|Tong, Weidong|Zhang, Lianyang|Liu, Baohua|Hu, Chuanmin
PMID: 19621336
Journal: Orv Hetil. 2009 Aug 23;150(34):1607-13.
Title: [Tissue microarray (TMA) validated progression markers in colorectal cancer using antibody microarrays].
Author: Spisak, Sandor|Galamb, Barnabas|Wichmann, Barnabas|Sipos, Ferenc|Galamb, Orsolya|Solymosi, Norbert|Nemes, Balazs|Tulassay, Zsolt|Molnar, Bela
PMID: 19648079
Journal: Mol Cancer Res. 2009 Aug;7(8):1390-8.
Title: Up-regulation of Kruppel-like factor 5 in pancreatic cancer is promoted by interleukin-1beta signaling and hypoxia-inducible factor-1alpha.
Author: Mori, Akira|Moser, Christian|Lang, Sven A|Hackl, Christina|Gottfried, Eva|Kreutz, Marina|Schlitt, Hans J|Geissler, Edward K|Stoeltzing, Oliver
PMID: 19671674
Journal: Chem Biol Interact. 2009 Dec 10;182(2-3):183-90.
Title: Novel nitro-oxy derivatives of celecoxib for the regulation of colon cancer cell growth.
Author: Bozzo, Francesca|Bassignana, Andrea|Lazzarato, Loretta|Boschi, Donatella|Gasco, Alberto|Bocca, Claudia|Miglietta, Antonella
PMID: 19682443
Journal: Biomed Environ Sci. 2009 Jun;22(3):244-52.
Title: Role of prosurvival molecules in the action of lidamycin toward human tumor cells.
Author: Yang, A-Jing|Shi, Wei-Wei|Li, Yong|Wang, Zhen|Shao, Rong-Guang|Li, Dian-Dong|He, Qi-Yang
PMID: 19725468
Journal: Apoptosis. 2009 Nov;14(11):1266-73.
Title: Death of ouabain-treated renal epithelial cells: evidence for p38 MAPK-mediated Na (i) (+) /K (i) (+) -independent signaling.
Author: Akimova, Olga A|Lopina, Olga D|Rubtsov, Alexander M|Gekle, Michel|Tremblay, Johanne|Hamet, Pavel|Orlov, Sergei N
PMID: 19784777
Journal: Int J Oncol. 2009 Nov;35(5):977-82.
Title: Analysis of candidate target genes for mononucleotide repeat mutation in microsatellite instability-high (MSI-H) endometrial cancer.
Author: Kawaguchi, Makiko|Banno, Kouji|Yanokura, Megumi|Kobayashi, Yusuke|Kishimi, Arisa|Ogawa, Seiji|Kisu, Iori|Nomura, Hiroyuki|Hirasawa, Akira|Susumu, Nobuyuki|Aoki, Daisuke
PMID: 19787250
Journal: Int J Oncol. 2009 Nov;35(5):1037-43.
Title: Synergistic effects of lovastatin and celecoxib on caveolin-1 and its down-stream signaling molecules: Implications for colon cancer prevention.
Author: Guruswamy, Suresh|Rao, Chinthalapally V
PMID: 19787257
Journal: Cancer Res. 2009 Oct 15;69(20):8191-9.
Title: RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects.
Author: Kreeger, Pamela K|Mandhana, Roli|Alford, Shannon K|Haigis, Kevin M|Lauffenburger, Douglas A
PMID: 19789336
Journal: Nutr Cancer. 2009;61(4):564-71.
Title: Salvia fruticosa, Salvia officinalis, and rosmarinic acid induce apoptosis and inhibit proliferation of human colorectal cell lines: the role in MAPK/ERK pathway.
Author: Xavier, Cristina P R|Lima, Cristovao F|Fernandes-Ferreira, Manuel|Pereira-Wilson, Cristina
PMID: 19838929
Journal: Mol Cancer Ther. 2009 Nov;8(11):3009-14.
Title: Efficacy of IGFBP7 for treatment of metastatic melanoma and other cancers in mouse models and human cell lines.
Author: Wajapeyee, Narendra|Kapoor, Varun|Mahalingam, Meera|Green, Michael R
PMID: 19861408
Journal: Cell. 2009 Nov 13;139(4):679-92.
Title: Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression.
Author: Genander, Maria|Halford, Michael M|Xu, Nan-Jie|Eriksson, Malin|Yu, Zuoren|Qiu, Zhaozhu|Martling, Anna|Greicius, Gedas|Thakar, Sonal|Catchpole, Timothy|Chumley, Michael J|Zdunek, Sofia|Wang, Chenguang|Holm, Torbjorn|Goff, Stephen P|Pettersson, Sven|Pestell
PMID: 19914164
Journal: BMC Cancer. 2009 Dec 12;9:435.
Title: Aurora-A overexpression enhances cell-aggregation of Ha-ras transformants through the MEK/ERK signaling pathway.
Author: Tseng, Ya-Shih|Lee, Jenq-Chang|Huang, Chi-Ying F|Liu, Hsiao-Sheng
PMID: 20003375
Journal: Mol Cancer. 2009 Dec 16;8:124.
Title: The protein tyrosine phosphatase receptor type R gene is an early and frequent target of silencing in human colorectal tumorigenesis.
Author: Menigatti, Mirco|Cattaneo, Elisa|Sabates-Bellver, Jacob|Ilinsky, Valery V|Went, Philip|Buffoli, Federico|Marquez, Victor E|Jiricny, Josef|Marra, Giancarlo
PMID: 20015382
Journal: Zhonghua Zhong Liu Za Zhi. 2009 Oct;31(10):746-851.
Title: [Combination with SN-38 on human colon cancer LoVo cells].
Author: Wang, Yan|Xu, Jian-ming|Xu, Qin-zhi|Zhou, Ping-kun|Song, San-tai
PMID: 20021826
Journal: Mol Med Rep. 2009 May-Jun;2(3):497-502.
Title: Effect of butyrate on the heregulin/ErbB-mediated proliferation of human colorectal cancer cells.
Author: Lim, Soo-Jeong|Choi, Moon-Kyung|Kim, Min Jung|Lee, Chang-Hun
PMID: 21475856
Journal: Int J Cancer. 2010 Feb 15;126(4):864-75.
Title: CCK2 receptor expression transforms non-tumorigenic human NCM356 colonic epithelial cells into tumor forming cells.
Author: Chao, Celia|Han, Xueliang|Ives, Kirk|Park, Jeseong|Kolokoltsov, Andrey A|Davey, Robert A|Moyer, Mary P|Hellmich, Mark R
PMID: 19697327
Journal: Pancreas. 2010 Apr;39(3):332-9.
Title: Loss of 15-hydroxyprostaglandin dehydrogenase increases prostaglandin E2 in pancreatic tumors.
Author: Pham, Hung|Chen, Monica|Li, Aihua|King, Jonathan|Angst, Eliane|Dawson, David W|Park, Jenny|Reber, Howard A|Hines, O Joe|Eibl, Guido
PMID: 19820419
Journal: Biochimie. 2010 Jan;92(1):110-5.
Title: Rottlerin induces heme oxygenase-1 (HO-1) up-regulation through reactive oxygen species (ROS) dependent and PKC delta-independent pathway in human colon cancer HT29 cells.
Author: Park, Eun Jung|Lim, Jun Hee|Nam, Sung Il|Park, Jong Wook|Kwon, Taeg Kyu
PMID: 19833168
Journal: Apoptosis. 2010 Feb;15(2):183-95.
Title: Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling.
Author: El-Najjar, Nahed|Chatila, Manal|Moukadem, Hiba|Vuorela, Heikki|Ocker, Matthias|Gandesiri, Muktheshwar|Schneider-Stock, Regine|Gali-Muhtasib, Hala
PMID: 19882352
Journal: Int J Cancer. 2010 May 1;126(9):2003-11.
Title: The role of Eph receptors and ephrin ligands in colorectal cancer.
Author: Herath, Nirmitha I|Boyd, Andrew W
PMID: 20039322
Journal: Mol Cancer. 2010 Feb 19;9:39.
Title: Analysis of an alternative human CD133 promoter reveals the implication of Ras/ERK pathway in tumor stem-like hallmarks.
Author: Tabu, Kouichi|Kimura, Taichi|Sasai, Ken|Wang, Lei|Bizen, Norihisa|Nishihara, Hiroshi|Taga, Tetsuya|Tanaka, Shinya
PMID: 20167130
Journal: Cell Commun Signal. 2010 Feb 2;8(1):1.
Title: High Erk activity suppresses expression of the cell cycle inhibitor p27Kip1 in colorectal cancer cells.
Author: Kress, Theresia R|Raabe, Thomas|Feller, Stephan M
PMID: 20181064
Journal: Cell Biol Int. 2010 Apr 14;34(6):565-72.
Title: Hydrogen sulfide induces human colon cancer cell proliferation: role of Akt, ERK and p21.
Author: Cai, Wen-Jie|Wang, Ming-Jie|Ju, Li-Hua|Wang, Cheng|Zhu, Yi-Chun
PMID: 20184555
Journal: Int J Oncol. 2010 Apr;36(4):941-53.
Title: Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway.
Author: Lee, Hwa Young|Crawley, Suzanne|Hokari, Ryota|Kwon, Sungwon|Kim, Young S
PMID: 20198339
Journal: BMC Cancer. 2010 Mar 16;10:99.
Title: Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study.
Author: Naguib, Adam|Mitrou, Panagiota N|Gay, Laura J|Cooke, James C|Luben, Robert N|Ball, Richard Y|McTaggart, Alison|Arends, Mark J|Rodwell, Sheila A
PMID: 20233436
Journal: Int J Colorectal Dis. 2010 Jun;25(6):687-94.
Title: Loss of cell-surface receptor EphB2 is important for the growth, migration, and invasiveness of a colon cancer cell line.
Author: Senior, Paul V|Zhang, Benny X|Chan, Steven T F
PMID: 20339854
Journal: Chem Biol Interact. 2010 May 14;185(3):247-52.
Title: (-)-Epigallocatechin gallate inhibits growth and activation of the VEGF/VEGFR axis in human colorectal cancer cells.
Author: Shimizu, Masahito|Shirakami, Yohei|Sakai, Hiroyasu|Yasuda, Yoichi|Kubota, Masaya|Adachi, Seiji|Tsurumi, Hisashi|Hara, Yukihiko|Moriwaki, Hisataka
PMID: 20346928
Journal: Arch Biochem Biophys. 2010 Sep 1;501(1):52-7.
Title: (-)-Epigallocatechin-3-gallate inhibits Met signaling, proliferation, and invasiveness in human colon cancer cells.
Author: Larsen, Christine A|Dashwood, Roderick H
PMID: 20361925
Journal: J Biol Chem. 2010 Jun 18;285(25):19235-45.
Title: Induction of the apoptosis inhibitor ARC by Ras in human cancers.
Author: Wu, Lily|Nam, Young-Jae|Kung, Gloria|Crow, Michael T|Kitsis, Richard N
PMID: 20392691
Journal: Cell Oncol. 2010 Jan 1;32(4):245-57.
Title: Oncogenic K-ras activates p38 to maintain colorectal cancer cell proliferation during MEK inhibition.
Author: van Houdt, Winan J|de Bruijn, Menno T|Emmink, Benjamin L|Raats, Danielle|Hoogwater, Frederik J H|Borel Rinkes, Inne H M|Kranenburg, Onno
PMID: 20413844
Journal: Curr Opin Investig Drugs. 2010 Jun;11(6):699-706.
Title: PLX-4032, a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.
Author: Smalley, Keiran S M
PMID: 20496265
Journal: Planta Med. 2010 Nov;76(16):1827-33.
Title: Andrographolide exhibits anti-invasive activity against colon cancer cells via inhibition of MMP2 activity.
Author: Chao, Hsueh-Ping|Kuo, Cheng-Deng|Chiu, Jen-Hwey|Fu, Shu-Ling
PMID: 20539971
Journal: Exp Mol Med. 2010 Jul 31;42(7):514-23.
Title: A serum-stable branched dimeric anti-VEGF peptide blocks tumor growth via anti-angiogenic activity.
Author: Kim, Jung-Wook|Kim, Tae-Dong|Hong, Bok Sil|Kim, Oh Youn|Yoon, Wan-Hee|Chae, Chi-Bom|Gho, Yong Song
PMID: 20543548
Journal: J Biol Chem. 2010 Aug 13;285(33):25458-66.
Title: Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91/LRP-1 and NF-kappaB-mediated integrin alphaV expression.
Author: Chen, Jinn-Shiun|Hsu, Yuan-Ming|Chen, Chia-Chi|Chen, Li-Li|Lee, Chun-Chung|Huang, Tze-Sing
PMID: 20558745
Journal: Oncogene. 2010 Sep 16;29(37):5182-92.
Title: Activating transcription factor 2 (ATF2) controls tolfenamic acid-induced ATF3 expression via MAP kinase pathways.
Author: Lee, S-H|Bahn, J H|Whitlock, N C|Baek, S J
PMID: 20581861
Journal: Biochim Biophys Acta. 2010 Sep;1803(9):1106-13.
Title: P21-activated kinase 1 stimulates colon cancer cell growth and migration/invasion via ERK- and AKT-dependent pathways.
Author: Huynh, Nhi|Liu, Kevin H|Baldwin, Graham S|He, Hong
PMID: 20595063
Journal: Int J Mol Med. 2010 Sep;26(3):341-9.
Title: Astragalus saponins modulate mTOR and ERK signaling to promote apoptosis through the extrinsic pathway in HT-29 colon cancer cells.
Author: Auyeung, Kathy Ka-Wai|Mok, Nga-Lai|Wong, Ching-Man|Cho, Chi-Hin|Ko, Joshua Ka-Shun
PMID: 20664949
Journal: Mol Cancer Ther. 2010 Aug;9(8):2196-207.
Title: Gamma-tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptors.
Author: Kannappan, Ramaswamy|Ravindran, Jayaraj|Prasad, Sahdeo|Sung, Bokyung|Yadav, Vivek R|Reuter, Simone|Chaturvedi, Madan M|Aggarwal, Bharat B
PMID: 20682650
Journal: Anticancer Res. 2010 Jul;30(7):2659-66.
Title: Antiproliferative effect of a novel nitro-oxy derivative of celecoxib in human colon cancer cells: role of COX-2 and nitric oxide.
Author: Bocca, Claudia|Bozzo, Francesca|Bassignana, Andrea|Miglietta, Antonella
PMID: 20682995
Journal: Histopathology. 2010 Aug;57(2):233-43.
Title: Systematic assessment of protein phenotypes characterizing high-grade tumour budding in mismatch repair-proficient colorectal cancer.
Author: Karamitopoulou, Eva|Lugli, Alessandro|Panayiotides, Ioannis|Karakitsos, Petros|Peros, George|Rallis, George|Patsouris, Efstratios S|Terracciano, Luigi|Zlobec, Inti
PMID: 20716165
Journal: Br J Cancer. 2010 Sep 28;103(7):1025-33.
Title: Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer.
Author: Baba, Y|Nosho, K|Shima, K|Meyerhardt, J A|Chan, A T|Engelman, J A|Cantley, L C|Loda, M|Giovannucci, E|Fuchs, C S|Ogino, S
PMID: 20808308
Journal: Int J Oncol. 2010 Oct;37(4):951-62.
Title: P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910.
Author: Li, Liang-Hui|Zheng, Min-Hua|Luo, Qi|Ye, Qing|Feng, Bo|Lu, Ai-Guo|Wang, Ming-Liang|Chen, Xue-Hua|Su, Li-Ping|Liu, Bing-Ya
PMID: 20811717
Journal: Mol Cancer. 2010 Sep 2;9:231.
Title: Sprouty1, a new target of the angiostatic agent 16K prolactin, negatively regulates angiogenesis.
Author: Sabatel, Celine|Cornet, Anne M|Tabruyn, Sebastien P|Malvaux, Ludovic|Castermans, Karolien|Martial, Joseph A|Struman, Ingrid
PMID: 20813052
Journal: J Immunol. 2010 Oct 1;185(7):3970-9.
Title: B7h triggering inhibits umbilical vascular endothelial cell adhesiveness to tumor cell lines and polymorphonuclear cells.
Author: Dianzani, Chiara|Minelli, Rosalba|Mesturini, Riccardo|Chiocchetti, Annalisa|Barrera, Giuseppina|Boscolo, Sabrina|Sarasso, Chiara|Gigliotti, Casimiro Luca|Sblattero, Daniele|Yagi, Junji|Rojo, Jose Maria|Fantozzi, Roberto|Dianzani, Umberto
PMID: 20817864
Journal: J Biol Chem. 2010 Nov 12;285(46):35418-27.
Title: Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.
Author: Sung, Bokyung|Ravindran, Jayaraj|Prasad, Sahdeo|Pandey, Manoj K|Aggarwal, Bharat B
PMID: 20837473
Journal: J Agric Food Chem. 2010 Oct 27;58(20):11148-55.
Title: Phenethyl isothiocyanate inhibited tumor migration and invasion via suppressing multiple signal transduction pathways in human colon cancer HT29 cells.
Author: Lai, Kuang-Chi|Hsu, Shu-Chun|Kuo, Chao-Lin|Ip, Siu-Wan|Yang, Jai-Sing|Hsu, Yuan-Man|Huang, Hui-Ying|Wu, Shin-Hwar|Chung, Jing-Gung
PMID: 20863062
Journal: Cancer Biol Ther. 2010 Nov 15;10(10):1056-66.
Title: The induction of S100p expression by the Prostaglandin E(2) (PGE(2))/EP4 receptor signaling pathway in colon cancer cells.
Author: Chandramouli, Anupama|Mercado-Pimentel, Melania E|Hutchinson, Anthony|Gibadulinova, Adriana|Olson, Erik R|Dickinson, Sally|Shanas, Renee|Davenport, Jennifer|Owens, Janae|Bhattacharyya, Achyut K|Regan, John W|Pastorekova, Silvia|Arumugam, Thiruvengadam|Log
PMID: 20890108
Journal: Sci Signal. 2010 Nov 23;3(149):ra84.
Title: BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation.
Author: Corcoran, Ryan B|Dias-Santagata, Dora|Bergethon, Kristin|Iafrate, A John|Settleman, Jeffrey|Engelman, Jeffrey A
PMID: 21098728
Journal: PLoS Genet. 2010 Dec 2;6(12):e1001231.
Title: Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells.
Author: Jurchott, Karsten|Kuban, Ralf-Jurgen|Krech, Till|Bluthgen, Nils|Stein, Ulrike|Walther, Wolfgang|Friese, Christian|Kielbasa, Szymon M|Ungethum, Ute|Lund, Per|Knosel, Thomas|Kemmner, Wolfgang|Morkel, Markus|Fritzmann, Johannes|Schlag, Peter M|Birchmeier, Wa
PMID: 21170361
Journal: Clin Genet. 2011 May;79(5):468-74.
Title: Germline mutation in BRAF codon 600 is compatible with human development: de novo p.V600G mutation identified in a patient with CFC syndrome.
Author: Champion, K J|Bunag, C|Estep, A L|Jones, J R|Bolt, C H|Rogers, R C|Rauen, K A|Everman, D B
PMID: 20735442
Journal: J Cell Physiol. 2011 Apr;226(4):1060-8.
Title: Thrombin induces expression of twist and cell motility via the hypoxia-inducible factor-1alpha translational pathway in colorectal cancer cells.
Author: Chang, Li-Hsun|Chen, Chun-Han|Huang, Der-Yi|Pai, Hui-Chen|Pan, Shiow-Lin|Teng, Che-Ming
PMID: 20857420
Journal: Cancer Res. 2011 Jan 15;71(2):445-53.
Title: MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal cancer that is resistant to EGFR monoclonal antibody therapy.
Author: Yoon, Juyong|Koo, Kyoung-Hwa|Choi, Kang-Yell
PMID: 21118963
Journal: Ann Surg Oncol. 2011 May;18(5):1501-5.
Title: Influence of A9 region mutation in EphB2 gene in the prognosis of patients with colorectal adenocarcinoma.
Author: Vidaurreta, M|Rafael, S|Veganzones, S|de la Orden, V|Fernandez, C|Gomez-Casaseca, R|Cerdan, J|Maestro, M
PMID: 21161727
Journal: BMC Cancer. 2011 Jan 11;11:11.
Title: ABI3 ectopic expression reduces in vitro and in vivo cell growth properties while inducing senescence.
Author: Latini, Flavia R M|Hemerly, Jefferson P|Freitas, Beatriz C G|Oler, Gisele|Riggins, Gregory J|Cerutti, Janete M
PMID: 21223585
Journal: Pathology. 2011 Feb;43(2):133-7.
Title: Loss of E-cadherin independently predicts the lymph node status in colorectal cancer.
Author: Karamitopoulou, E|Zlobec, I|Patsouris, Es|Peros, G|Lugli, A
PMID: 21233674
Journal: Cancer Res. 2011 Feb 1;71(3):998-1008.
Title: Smad4 inactivation promotes malignancy and drug resistance of colon cancer.
Author: Papageorgis, Panagiotis|Cheng, Kuanghung|Ozturk, Sait|Gong, Yi|Lambert, Arthur W|Abdolmaleky, Hamid M|Zhou, Jin-Rong|Thiagalingam, Sam
PMID: 21245094
Journal: Am J Physiol Gastrointest Liver Physiol. 2011 May;300(5):G749-60.
Title: Muscarinic receptor agonists stimulate human colon cancer cell migration and invasion.
Author: Belo, Angelica|Cheng, Kunrong|Chahdi, Ahmed|Shant, Jasleen|Xie, Guofeng|Khurana, Sandeep|Raufman, Jean-Pierre
PMID: 21273532
Journal: J Mol Signal. 2011 Mar 3;6:2.
Title: Activation of K-RAS by co-mutation of codons 19 and 20 is transforming.
Author: Naguib, Adam|Wilson, Catherine H|Adams, David J|Arends, Mark J
PMID: 21371307
Journal: PLoS One. 2011 Feb 17;6(2):e16871.
Title: Functional characterization of human cancer-derived TRKB mutations.
Author: Geiger, Thomas R|Song, Ji-Ying|Rosado, Aranzazu|Peeper, Daniel S
PMID: 21379385
Journal: Epigenetics. 2011 May;6(5):610-22. Epub 2011 May 1.
Title: Class I and III HDACs and loss of active chromatin features contribute to epigenetic silencing of CDX1 and EPHB tumor suppressor genes in colorectal cancer.
Author: Ronsch, Kerstin|Jager, Marcel|Schopflin, Anja|Danciu, Mihai|Lassmann, Silke|Hecht, Andreas
PMID: 21393996
Journal: Cell Stem Cell. 2011 May 6;8(5):511-24.
Title: The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse.
Author: Merlos-Suarez, Anna|Barriga, Francisco M|Jung, Peter|Iglesias, Mar|Cespedes, Maria Virtudes|Rossell, David|Sevillano, Marta|Hernando-Momblona, Xavier|da Silva-Diz, Victoria|Munoz, Purificacion|Clevers, Hans|Sancho, Elena|Mangues, Ramon|Batlle, Eduard
PMID: 21419747
Journal: J Biol Chem. 2011 May 20;286(20):18104-17.
Title: Protein kinase Calpha signaling regulates inhibitor of DNA binding 1 in the intestinal epithelium.
Author: Hao, Fang|Pysz, Marybeth A|Curry, Kathryn J|Haas, Kristin N|Seedhouse, Steven J|Black, Adrian R|Black, Jennifer D
PMID: 21454537
Journal: PLoS One. 2011 Mar 25;6(3):e18087.
Title: HDAC inhibition decreases the expression of EGFR in colorectal cancer cells.
Author: Chou, Chia-Wei|Wu, Ming-Shiang|Huang, Wei-Chien|Chen, Ching-Chow
PMID: 21464950
Journal: Int J Oncol. 2011 Jul;39(1):33-40.
Title: Sesamin induces autophagy in colon cancer cells by reducing tyrosine phosphorylation of EphA1 and EphB2.
Author: Tanabe, Hiromi|Kuribayashi, Kageaki|Tsuji, Naoki|Tanaka, Maki|Kobayashi, Daisuke|Watanabe, Naoki
PMID: 21503576
Journal: Cancer Lett. 2011 Sep 1;308(1):62-70.
Title: RasGAP-derived peptide 38GAP potentiates the cytotoxicity of cisplatin through inhibitions of Akt, ERK and NF-kappaB in colon carcinoma HCT116 cells.
Author: Zhang, Hao|Zhang, Shenghua|He, Hongwei|Zhao, Wuli|Ren, Kaihuan|Chen, Jianhua|Shao, Rong-guang
PMID: 21570766
Journal: PLoS One. 2011;6(5):e19494.
Title: EphB2 SNPs and sporadic prostate cancer risk in African American men.
Author: Robbins, Christiane M|Hooker, Stanley|Kittles, Rick A|Carpten, John D
PMID: 21603658
Journal: Toxicol Appl Pharmacol. 2011 Aug 1;254(3):288-98.
Title: 5-Methoxyflavanone induces cell cycle arrest at the G2/M phase, apoptosis and autophagy in HCT116 human colon cancer cells.
Author: Shin, Soon Young|Hyun, Jiye|Yu, Jae-Ran|Lim, Yoongho|Lee, Young Han
PMID: 21616090
Journal: J Pathol. 2011 Nov;225(3):336-43.
Title: Comprehensive analysis of CpG island methylator phenotype (CIMP)-high, -low, and -negative colorectal cancers based on protein marker expression and molecular features.
Author: Zlobec, Inti|Bihl, Michel|Foerster, Anja|Rufle, Alex|Lugli, Alessandro
PMID: 21660972
Journal: Hum Pathol. 2011 Dec;42(12):1888-96.
Title: Systematic analysis of proteins from different signaling pathways in the tumor center and the invasive front of colorectal cancer.
Author: Karamitopoulou, Eva|Zlobec, Inti|Panayiotides, Ioannis|Patsouris, Efstratios S|Peros, George|Rallis, George|Lapas, Christos|Karakitsos, Petros|Terracciano, Luigi M|Lugli, Alessandro
PMID: 21664646
Journal: BMC Dev Biol. 2011 Jun 14;11:41.
Title: The Drosophila Netrin receptor frazzled/DCC functions as an invasive tumor suppressor.
Author: VanZomeren-Dohm, Adrienne|Sarro, Joseph|Flannery, Ellen|Duman-Scheel, Molly
PMID: 21672235
Journal: Biochim Biophys Acta. 2011 Jul;1809(7):306-15.
Title: Dickkopf homolog 1, a Wnt signaling antagonist, is transcriptionally up-regulated via an ATF4-independent and MAPK/ERK-dependent pathway following amino acid deprivation.
Author: Zhou, Dan|Zhang, Yukun|Pan, Yuan-Xiang|Chen, Hong
PMID: 21683813
Journal: PLoS One. 2011;6(6):e21317.
Title: Proteasome particle-rich structures are widely present in human epithelial neoplasms: correlative light, confocal and electron microscopy study.
Author: Necchi, Vittorio|Sommi, Patrizia|Vanoli, Alessandro|Manca, Rachele|Ricci, Vittorio|Solcia, Enrico
PMID: 21695063
Journal: BMC Cancer. 2011 Jul 1;11:285.
Title: Survival advantages conferred to colon cancer cells by E-selectin-induced activation of the PI3K-NFkappaB survival axis downstream of Death receptor-3.
Author: Porquet, Nicolas|Poirier, Andree|Houle, Francois|Pin, Anne-Laure|Gout, Stephanie|Tremblay, Pierre-Luc|Paquet, Eric R|Klinck, Roscoe|Auger, Francois A|Huot, Jacques
PMID: 21722370
Journal: PLoS One. 2011;6(8):e23262.
Title: TRAPPC4-ERK2 interaction activates ERK1/2, modulates its nuclear localization and regulates proliferation and apoptosis of colorectal cancer cells.
Author: Zhao, Shu-Liang|Hong, Jie|Xie, Zuo-Quan|Tang, Jie-Ting|Su, Wen-Yu|Du, Wan|Chen, Ying-Xuan|Lu, Rong|Sun, Dan-Feng|Fang, Jing-Yuan
PMID: 21826244
Journal: Oncotarget. 2011 Aug;2(8):638-45.
Title: The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer.
Author: Mazumdar, Tapati|DeVecchio, Jennifer|Agyeman, Akwasi|Shi, Ting|Houghton, Janet A
PMID: 21860067
Journal: Chem Biol Interact. 2011 Oct 15;194(1):48-57.
Title: Cell cycle arrest and apoptosis induced by methyl 3,5-dicaffeoyl quinate in human colon cancer cells: Involvement of the PI3K/Akt and MAP kinase pathways.
Author: Hu, Weicheng|Shen, Ting|Wang, Myeong-Hyeon
PMID: 21872580
Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Jul;36(7):585-91.
Title: [Transcriptomic regulation and molecular mechanism of polygenic tumor at different stages].
Author: Li, Xiayu|Shen, Shourong|Wu, Minghua|Li, Xiaoling|Xiong, Wei|Lu, Jianhong|Zhou, Ming|Ma, Jian|Xiang, Juanjuan|Zeng, Zhaoyang|Xiang, Bo|Zhou, Yanhong|Xiao, Lan|Zhou, Houde|Fan, Songqing|Li, Guiyuan
PMID: 21873780
Journal: Radiat Oncol. 2011 Sep 12;6:114.
Title: Phospho-ERK and AKT status, but not KRAS mutation status, are associated with outcomes in rectal cancer treated with chemoradiotherapy.
Author: Davies, Janine M|Trembath, Dimitri|Deal, Allison M|Funkhouser, William K|Calvo, Benjamin F|Finnegan, Timothy|Weck, Karen E|Tepper, Joel E|O'Neil, Bert H
PMID: 21910869
Journal: J Agric Food Chem. 2011 Oct 26;59(20):11304-18.
Title: Cancer chemopreventive effects of lycopene: suppression of MMP-7 expression and cell invasion in human colon cancer cells.
Author: Lin, Meng-Chiu|Wang, Fu-Yu|Kuo, Yueh-Hsiung|Tang, Feng-Yao
PMID: 21923160
Journal: Toxicol In Vitro. 2011 Dec;25(8):1771-81.
Title: Dietary flavanols exert different effects on antioxidant defenses and apoptosis/proliferation in Caco-2 and SW480 colon cancer cells.
Author: Ramos, Sonia|Rodriguez-Ramiro, Ildefonso|Martin, Maria Angeles|Goya, Luis|Bravo, Laura
PMID: 21945981
Journal: Cancer Lett. 2011 Dec 27;313(2):167-80.
Title: Lunasin potentiates the effect of oxaliplatin preventing outgrowth of colon cancer metastasis, binds to alpha5beta1 integrin and suppresses FAK/ERK/NF-kappaB signaling.
Author: Dia, Vermont P|Gonzalez de Mejia, Elvira
PMID: 21963225
Journal: J Clin Invest. 2011 Nov;121(11):4311-21.
Title: Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers.
Author: Ebi, Hiromichi|Corcoran, Ryan B|Singh, Anurag|Chen, Zhao|Song, Youngchul|Lifshits, Eugene|Ryan, David P|Meyerhardt, Jeffrey A|Benes, Cyril|Settleman, Jeffrey|Wong, Kwok-Kin|Cantley, Lewis C|Engelman, Jeffrey A
PMID: 21985784
Journal: PLoS One. 2011;6(10):e25806.
Title: BRAF mutations in advanced cancers: clinical characteristics and outcomes.
Author: El-Osta, Hazem|Falchook, Gerald|Tsimberidou, Apostolia|Hong, David|Naing, Aung|Kim, Kevin|Wen, Sijin|Janku, Filip|Kurzrock, Razelle
PMID: 22039425
Journal: Cancer Cell. 2011 Nov 15;20(5):649-60.
Title: The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis.
Author: Zaki, Md Hasan|Vogel, Peter|Malireddi, R K Subbarao|Body-Malapel, Mathilde|Anand, Paras K|Bertin, John|Green, Douglas R|Lamkanfi, Mohamed|Kanneganti, Thirumala-Devi
PMID: 22094258
Journal: Oncol Res. 2011;19(12):527-34.
Title: RIN1-Ras-ERK pathway plays an important role in carcinogenesis in colon cancer cell line LoVo.
Author: Inoue, Takeshi|Goi, Takanori|Hirono, Yasuo|Katayama, Kanji|Yamaguchi, Akio
PMID: 22812185
Journal: Cancers (Basel). 2011 Mar 2;3(1):971-81.
Title: Muscarinic receptor signaling in colon cancer.
Author: Von Rosenvinge, Erik C|Raufman, Jean-Pierre
PMID: 24212649
Journal: Eur J Cancer. 2012 Mar;48(5):753-62.
Title: Complex expression patterns of Eph receptor tyrosine kinases and their ephrin ligands in colorectal carcinogenesis.
Author: Herath, Nirmitha I|Spanevello, Mark D|Doecke, James D|Smith, Fiona M|Pouponnot, Celio|Boyd, Andrew W
PMID: 21852108
Journal: Int J Oncol. 2012 Jan;40(1):176-84.
Title: The effect of a dimeric Affibody molecule (ZEGFR:1907)2 targeting EGFR in combination with radiation in colon cancer cell lines.
Author: Haggblad Sahlberg, Sara|Spiegelberg, Diana|Lennartsson, Johan|Nygren, Peter|Glimelius, Bengt|Stenerlow, Bo
PMID: 21879255
Journal: Mol Carcinog. 2012 Oct;51(10):783-95.
Title: Celecoxib inactivates epithelial-mesenchymal transition stimulated by hypoxia and/or epidermal growth factor in colon cancer cells.
Author: Bocca, Claudia|Bozzo, Francesca|Cannito, Stefania|Parola, Maurizio|Miglietta, Antonella
PMID: 21882253
Journal: Br J Pharmacol. 2012 May;166(2):587-601.
Title: Cholesteryl butyrate solid lipid nanoparticles inhibit the adhesion and migration of colon cancer cells.
Author: Minelli, R|Serpe, L|Pettazzoni, P|Minero, V|Barrera, G|Gigliotti, Cl|Mesturini, R|Rosa, A C|Gasco, P|Vivenza, N|Muntoni, E|Fantozzi, R|Dianzani, U|Zara, G P|Dianzani, C
PMID: 22049973
Journal: Int J Cancer. 2012 Aug 1;131(3):E190-203.
Title: Phosphatase of regenerating liver-3 promotes migration and invasion by upregulating matrix metalloproteinases-7 in human colorectal cancer cells.
Author: Lee, Su-Kyung|Han, Young-Min|Yun, Jieun|Lee, Chang Woo|Shin, Dae-Seop|Ha, Young-Ran|Kim, Jina|Koh, Jong Sung|Hong, Su-Hyung|Han, Dong Cho|Kwon, Byoung-Mog
PMID: 22131018
Journal: Oncol Rep. 2012 Mar;27(3):727-33.
Title: Koetjapic acid, a natural triterpenoid, induces apoptosis in colon cancer cells.
Author: Nassar, Zeyad D|Aisha, Abdalrahim F A|Idris, Norshirin|Khadeer Ahamed, Mohamed B|Ismail, Zhari|Abu-Salah, Khalid M|Alrokayan, Salman A|Shah Abdul Majid, Amin Malik
PMID: 22134768
Journal: Int J Oncol. 2012 Apr;40(4):1251-8.
Title: Multiple antitumor effects of picropodophyllin in colon carcinoma cell lines: clinical implications.
Author: Feng, Xiaoying|Aleem, Eiman|Lin, Yingbo|Axelson, Magnus|Larsson, Olle|Stromberg, Thomas
PMID: 22159423
Journal: Cancer Res. 2012 Feb 1;72(3):779-89.
Title: Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer.
Author: Yang, Hong|Higgins, Brian|Kolinsky, Kenneth|Packman, Kathryn|Bradley, William D|Lee, Richard J|Schostack, Kathleen|Simcox, Mary Ellen|Kopetz, Scott|Heimbrook, David|Lestini, Brian|Bollag, Gideon|Su, Fei
PMID: 22180495
Journal: Eur J Pharmacol. 2012 Feb 29;677(1-3):22-30.
Title: The anti-angiogenic and anti-tumor activity of synthetic phenylpropenone derivatives is mediated through the inhibition of receptor tyrosine kinases.
Author: Lee, Jong-Suk|Kang, Youra|Kim, Jong Tae|Thapa, Dinesh|Lee, Eung-Seok|Kim, Jung-Ae
PMID: 22200628
Journal: J Nutr Biochem. 2012 Oct;23(10):1302-13.
Title: Consumption of high-fat diet induces tumor progression and epithelial-mesenchymal transition of colorectal cancer in a mouse xenograft model.
Author: Tang, Feng-Yao|Pai, Man-Hui|Chiang, En-Pei Isabel
PMID: 22221675
Journal: J Mol Med (Berl). 2012 Jun;90(6):707-18.
Title: Gastrin inhibits a novel, pathological colon cancer signaling pathway involving EGR1, AE2, and P-ERK.
Author: Song, Ling-Jun|Liu, Rui-Jun|Zeng, Zhi|Alper, Seth L|Cui, Heng-Jing|Lu, Yang|Zheng, Lin|Yan, Zhao-Wen|Fu, Guo-Hui
PMID: 22228178
Journal: Biochem Soc Trans. 2012 Feb;40(1):73-8.
Title: Tumour cell responses to MEK1/2 inhibitors: acquired resistance and pathway remodelling.
Author: Little, Annette S|Balmanno, Kathryn|Sale, Matthew J|Smith, Paul D|Cook, Simon J
PMID: 22260668
Journal: Exp Cell Res. 2012 Mar 10;318(5):550-7.
Title: Dab2 is pivotal for endothelial cell migration by mediating VEGF expression in cancer cells.
Author: Cheong, Seong-Moon|Choi, Hyemin|Hong, Bok Sil|Gho, Yong Song|Han, Jin-Kwan
PMID: 22265793
Journal: PLoS One. 2012;7(1):e29532.
Title: A new model for raf kinase inhibitory protein induced chemotherapeutic resistance.
Author: Al-Mulla, Fahd|Bitar, Milad S|Feng, Jingwei|Park, Sungdae|Yeung, Kam C
PMID: 22279539
Journal: Cancer Res. 2012 Feb 1;72(3):626-35.
Title: Sef downregulation by Ras causes MEK1/2 to become aberrantly nuclear localized leading to polyploidy and neoplastic transformation.
Author: Duhamel, Stephanie|Hebert, Josee|Gaboury, Louis|Bouchard, Amelie|Simon, Ronald|Sauter, Guido|Basik, Mark|Meloche, Sylvain
PMID: 22298595
Journal: Int J Mol Med. 2012 May;29(5):920-6.
Title: MicroRNA-21-mediated regulation of Sprouty2 protein expression enhances the cytotoxic effect of 5-fluorouracil and metformin in colon cancer cells.
Author: Feng, Yin-Hsun|Wu, Chao-Liang|Shiau, Ai-Li|Lee, Jenq-Chang|Chang, Jan-Gowth|Lu, Pei-Jung|Tung, Chao-Ling|Feng, Li-Yia|Huang, Wen-Tsung|Tsao, Chao-Jung
PMID: 22322462
Journal: Oncol Rep. 2012 May;27(5):1527-34.
Title: NF-kappaB activity is downregulated by KRAS knockdown in SW620 cells via the RAS-ERK-IkappaBalpha pathway.
Author: Lin, Gen|Tang, Zhiwei|Ye, Yun-Bin|Chen, Qiang
PMID: 22327383
Journal: World J Surg Oncol. 2012 Feb 29;10:47.
Title: ERK/pERK expression and B-raf mutations in colon adenocarcinomas: correlation with clinicopathological characteristics.
Author: Levidou, Georgia|Saetta, Angelica A|Gigelou, Fanie|Karlou, Maria|Papanastasiou, Polyanthi|Stamatelli, Angeliki|Kavantzas, Nikolaos|Michalopoulos, Nikolaos V|Agrogiannis, George|Patsouris, Efstratios|Korkolopoulou, Penelope
PMID: 22376079
Journal: Am J Physiol Gastrointest Liver Physiol. 2012 May 15;302(10):G1223-30.
Title: Oncogenic KRAS regulates BMP4 expression in colon cancer cell lines.
Author: Duerr, Eva-Maria|Mizukami, Yusuke|Moriichi, Kentaro|Gala, Manish|Jo, Won-Seok|Kikuchi, Hirotoshi|Xavier, Ramnik J|Chung, Daniel C
PMID: 22383492
Journal: Chem Biol Interact. 2012 Apr 15;197(1):1-7.
Title: Rottlerin induces apoptosis of HT29 colon carcinoma cells through NAG-1 upregulation via an ERK and p38 MAPK-dependent and PKC delta-independent mechanism.
Author: Lim, Jun Hee|Woo, Seon Min|Min, Kyoung-Jin|Park, Eun Jung|Jang, Ji Hoon|Seo, Bo Ram|Iqbal, Taha|Lee, Tae-Jin|Kim, Sang Hyun|Choi, Yung Hyun|Kwon, Taeg Kyu
PMID: 22410117
Journal: J Orthop Res. 2012 Sep;30(9):1486-92.
Title: The natural compound Alizarin as an osteotropic drug for the treatment of bone tumors.
Author: Fotia, Caterina|Avnet, Sofia|Granchi, Donatella|Baldini, Nicola
PMID: 22411621
Journal: Br J Cancer. 2012 Apr 10;106(8):1386-94.
Title: The synergistic interaction of MEK and PI3K inhibitors is modulated by mTOR inhibition.
Author: Haagensen, E J|Kyle, S|Beale, G S|Maxwell, R J|Newell, D R
PMID: 22415236
Journal: Cancer Discov. 2012 Mar;2(3):227-35.
Title: EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib.
Author: Corcoran, Ryan B|Ebi, Hiromichi|Turke, Alexa B|Coffee, Erin M|Nishino, Michiya|Cogdill, Alexandria P|Brown, Ronald D|Della Pelle, Patricia|Dias-Santagata, Dora|Hung, Kenneth E|Flaherty, Keith T|Piris, Adriano|Wargo, Jennifer A|Settleman, Jeffrey|Mino-Kenu
PMID: 22448344
Journal: Phytomedicine. 2012 Jun 15;19(8-9):756-62.
Title: Triptolide inhibits colon-rectal cancer cells proliferation by induction of G1 phase arrest through upregulation of p21.
Author: Liu, Juanjuan|Shen, Min|Yue, Zhenggang|Yang, Zhifu|Wang, Meng|Li, Chen|Xin, Chunyan|Wang, Yukun|Mei, Qibing|Wang, Zhipeng
PMID: 22464014
Journal: Crit Rev Oncog. 2012;17(1):97-121.
Title: Aberrant B-Raf signaling in human cancer -- 10 years from bench to bedside.
Author: Roring, Michael|Brummer, Tilman
PMID: 22471666
Journal: Immunity. 2012 May 25;36(5):742-54.
Title: NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-kappaB signaling.
Author: Allen, Irving C|Wilson, Justin E|Schneider, Monika|Lich, John D|Roberts, Reid A|Arthur, Janelle C|Woodford, Rita-Marie T|Davis, Beckley K|Uronis, Joshua M|Herfarth, Hans H|Jobin, Christian|Rogers, Arlin B|Ting, Jenny P-Y
PMID: 22503542
Journal: Am J Physiol Gastrointest Liver Physiol. 2012 Jul;303(1):G111-9.
Title: Epidermal growth factor receptor transactivation is required for proteinase-activated receptor-2-induced COX-2 expression in intestinal epithelial cells.
Author: Hirota, Christina L|Moreau, France|Iablokov, Vadim|Dicay, Michael|Renaux, Bernard|Hollenberg, Morley D|MacNaughton, Wallace K
PMID: 22517768
Journal: Cancer Res. 2012 Jun 15;72(12):3060-8.
Title: Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth.
Author: Kim, Dong Joon|Li, Yan|Reddy, Kanamata|Lee, Mee-Hyun|Kim, Myoung Ok|Cho, Yong-Yeon|Lee, Sung-Young|Kim, Jong-Eun|Bode, Ann M|Dong, Zigang
PMID: 22523035
Journal: Biochim Biophys Acta. 2012 Jul;1820(7):1073-80.
Title: Thermostable direct hemolysin diminishes tyrosine phosphorylation of epidermal growth factor receptor through protein kinase C dependent mechanism.
Author: Karmakar, Poulomee|Chakrabarti, Manoj K
PMID: 22543197
Journal: Cancer Lett. 2012 Nov 1;324(1):98-108.
Title: Blocking p38/ERK crosstalk affects colorectal cancer growth by inducing apoptosis in vitro and in preclinical mouse models.
Author: Chiacchiera, Fulvio|Grossi, Valentina|Cappellari, Marianna|Peserico, Alessia|Simonatto, Marta|Germani, Aldo|Russo, Silvana|Moyer, Mary P|Resta, Nicoletta|Murzilli, Stefania|Simone, Cristiano
PMID: 22579651
Journal: Biochem Pharmacol. 2012 Aug 1;84(3):320-30.
Title: MiR-139 inhibits invasion and metastasis of colorectal cancer by targeting the type I insulin-like growth factor receptor.
Author: Shen, Ke|Liang, Qiannan|Xu, Ke|Cui, Daling|Jiang, Lin|Yin, Peihao|Lu, Yanhua|Li, Qi|Liu, Jianwen
PMID: 22580051
Journal: Int J Oncol. 2012 Aug;41(2):583-8.
Title: Differential response to EGFR- and VEGF-targeted therapies in patient-derived tumor tissue xenograft models of colon carcinoma and related metastases.
Author: Jin, Ketao|Lan, Huanrong|Cao, Feilin|Han, Na|Xu, Zhenzhen|Li, Guangliang|He, Kuifeng|Teng, Lisong
PMID: 22581265
Journal: Food Funct. 2012 Aug;3(8):844-52.
Title: Hypericum androsaemum water extract inhibits proliferation in human colorectal cancer cells through effects on MAP kinases and PI3K/Akt pathway.
Author: Xavier, Cristina P R|Lima, Cristovao F|Fernandes-Ferreira, Manuel|Pereira-Wilson, Cristina
PMID: 22596086
Journal: Free Radic Biol Med. 2012 Aug 1;53(3):532-43.
Title: P38 MAP kinase functions as a switch in MS-275-induced reactive oxygen species-dependent autophagy and apoptosis in human colon cancer cells.
Author: Zhan, Yao|Gong, Ke|Chen, Chao|Wang, Haiqing|Li, Wenhua
PMID: 22634147
Journal: Lab Invest. 2012 Aug;92(8):1203-12.
Title: Intestinal epithelial cell-specific CD98 expression regulates tumorigenesis in Apc(Min/+) mice.
Author: Nguyen, Hang Thi Thu|Dalmasso, Guillaume|Yan, Yutao|Laroui, Hamed|Charania, Moiz|Ingersoll, Sarah|Ayyadurai, Saravanan|Zhang, Yuchen|Sitaraman, Shanthi|Merlin, Didier
PMID: 22641098
Journal: Oncol Rep. 2012 Sep;28(3):931-6.
Title: Novel function of MKP-5/DUSP10, a phosphatase of stress-activated kinases, on ERK-dependent gene expression, and upregulation of its gene expression in colon carcinomas.
Author: Nomura, Miyuki|Shiiba, Ken-Ichi|Katagiri, Chiaki|Kasugai, Isao|Masuda, Kouhei|Sato, Ikuro|Sato, Masayuki|Kakugawa, Yoichiro|Nomura, Eiki|Hayashi, Katsuhisa|Nakamura, Yoshihiro|Nagata, Toshiyuki|Otsuka, Tsunayuki|Katakura, Ryuichi|Yamashita, Yoji|Sato, Mas
PMID: 22711061
Journal: Am J Physiol Gastrointest Liver Physiol. 2012 Aug 15;303(4):G443-52.
Title: CD24 can be used to isolate Lgr5+ putative colonic epithelial stem cells in mice.
Author: King, Jeffrey B|von Furstenberg, Richard J|Smith, Brian J|McNaughton, Kirk K|Galanko, Joseph A|Henning, Susan J
PMID: 22723265
Journal: Chembiochem. 2012 Jul 23;13(11):1663-72.
Title: DYZ-2-90, a novel neo-tanshinlactone ring-opened compound, induces ERK-mediated mitotic arrest and subsequent apoptosis by activating JNK in human colorectal cancer cells.
Author: Wang, Li-Ting|Pan, Shiow-Lin|Chen, Tzu-Hsuan|Dong, Yizhou|Lee, Kuo-Hsiung|Teng, Che-Ming
PMID: 22761044
Journal: Biochem Biophys Res Commun. 2012 Oct 26;427(3):444-9.
Title: MiR-145 regulates PAK4 via the MAPK pathway and exhibits an antitumor effect in human colon cells.
Author: Wang, Zhigang|Zhang, Xiaoping|Yang, Zhili|Du, Hangxiang|Wu, Zhenqian|Gong, Jianfeng|Yan, Jun|Zheng, Qi
PMID: 22766504
Journal: J Cancer Res Clin Oncol. 2012 Dec;138(12):2051-60.
Title: Cyclin D1 degradation and p21 induction contribute to growth inhibition of colorectal cancer cells induced by epigallocatechin-3-gallate.
Author: Zhang, Xiaobo|Min, Kyung-Won|Wimalasena, Jay|Baek, Seung Joon
PMID: 22814742
Journal: BMC Complement Altern Med. 2012 Jul 20;12:104.
Title: In vitro and in vivo anti-colon cancer effects of Garcinia mangostana xanthones extract.
Author: Aisha, Abdalrahim F A|Abu-Salah, Khalid M|Ismail, Zhari|Majid, Amin Malik Shah Abdul
PMID: 22818000
Journal: Carcinogenesis. 2012 Nov;33(11):2228-35.
Title: PAQR3 plays a suppressive role in the tumorigenesis of colorectal cancers.
Author: Wang, Xiao|Li, Xuebing|Fan, Fengjuan|Jiao, Shi|Wang, Lingdi|Zhu, Lu|Pan, Yi|Wu, Guohao|Ling, Zhi-Qiang|Fang, Jing|Chen, Yan
PMID: 22828136
Journal: BMC Cancer. 2012 Aug 1;12:331.
Title: A systems biology approach to the global analysis of transcription factors in colorectal cancer.
Author: Pradhan, Meeta P|Prasad, Nagendra K A|Palakal, Mathew J
PMID: 22852817
Journal: Int J Mol Med. 2012 Oct;30(4):734-8.
Title: Induction of apoptosis by laminarin, regulating the insulin-like growth factor-IR signaling pathways in HT-29 human colon cells.
Author: Park, Hee-Kyoung|Kim, In-Hye|Kim, Joongkyun|Nam, Taek-Jeong
PMID: 22859258
Journal: Pol J Pathol. 2012 Jun;63(2):93-100.
Title: Clinical-pathological correlation of K-Ras mutation and ERK phosphorylation in colorectal cancer.
Author: Tai, Cheng-Jeng|Chang, Chun-Chao|Jiang, Ming-Chung|Yeh, Chung-Min|Su, Tzu-Cheng|Wu, Pei-Ru|Chen, Chih-Jung|Yeh, Kun-Tu|Lin, Shu-Hui|Chen, Hung-Chang
PMID: 22864777
Journal: J Biol Chem. 2012 Nov 23;287(48):40371-80.
Title: Epidermal growth factor (EGF) regulates alpha5beta1 integrin activation state in human cancer cell lines through the p90RSK-dependent phosphorylation of filamin A.
Author: Vial, Daniel|McKeown-Longo, Paula J
PMID: 23007402
Journal: Curr Med Chem. 2012;19(33):5735-44.
Title: Signal transduction pathways of the epidermal growth factor receptor in colorectal cancer and their inhibition by small molecules.
Author: Efferth, T
PMID: 23033949
Journal: J Biomed Sci. 2012 Oct 25;19:91.
Title: CXC chemokine ligand 12/stromal cell-derived factor-1 regulates cell adhesion in human colon cancer cells by induction of intercellular adhesion molecule-1.
Author: Tung, Shui-Yi|Chang, Shun-Fu|Chou, Ming-Hui|Huang, Wen-Shih|Hsieh, Yung-Yu|Shen, Chien-Heng|Kuo, Hsing-Chun|Chen, Cheng-Nan
PMID: 23098564
Journal: PLoS One. 2012;7(10):e48461.
Title: Src-mediated cross-talk between farnesoid X and epidermal growth factor receptors inhibits human intestinal cell proliferation and tumorigenesis.
Author: Peng, Zhongsheng|Raufman, Jean-Pierre|Xie, Guofeng
PMID: 23119029
Journal: Life Sci. 2012 Dec 17;91(25-26):1336-44.
Title: Phenethyl caffeate benzo[kl]xanthene lignan with DNA interacting properties induces DNA damage and apoptosis in colon cancer cells.
Author: Vijayakurup, Vinod|Carmela, Spatafora|Carmelo, Daquino|Corrado, Tringali|Srinivas, Priya|Gopala, Srinivas
PMID: 23123449
Journal: Cell. 2012 Nov 21;151(5):937-50.
Title: MED12 controls the response to multiple cancer drugs through regulation of TGF-beta receptor signaling.
Author: Huang, Sidong|Holzel, Michael|Knijnenburg, Theo|Schlicker, Andreas|Roepman, Paul|McDermott, Ultan|Garnett, Mathew|Grernrum, Wipawadee|Sun, Chong|Prahallad, Anirudh|Groenendijk, Floris H|Mittempergher, Lorenza|Nijkamp, Wouter|Neefjes, Jacques|Salazar, Ramo
PMID: 23178117
Journal: Oncol Lett. 2012 Oct;4(4):783-791.
Title: MACC1: A potential molecule associated with pancreatic cancer metastasis and chemoresistance.
Author: Wang, Gang|Kang, Mu-Xing|Lu, Wen-Jie|Chen, Ying|Zhang, Bo|Wu, Yu-Lian
PMID: 23205101
Journal: Anal Quant Cytopathol Histpathol. 2012 Dec;34(6):309-16.
Title: Quantitative analysis of ERK signaling inhibition in colon cancer cell lines using phospho-specific flow cytometry.
Author: Lim, Sun Min|Hwang, Jee Won|Bae, Soo Kyung|Bae, Soo Hyeon|Ahn, Joong Bae|Rha, Sun Young|Roh, Jae Kyung|Chung, Hyun Cheol|Shin, Sang Joon
PMID: 23304816
Journal: Front Endocrinol (Lausanne). 2013 Jan 17;3:184.
Title: Neurotensin and its high affinity receptor 1 as a potential pharmacological target in cancer therapy.
Author: Wu, Zherui|Martinez-Fong, Daniel|Tredaniel, Jean|Forgez, Patricia
PMID: 23335914
Journal: World J Nucl Med. 2012 May;11(2):65-9.
Title: (18)F-FLT-PET for Response Evaluation of MEK Inhibitor Selumetinib (AZD6244, ARRY-142886) in Patients with Solid Tumors.
Author: Desar, Ingrid M E|Gilles, Rozemarie|van Herpen, Carla M L|Timmer-Bonte, Anja J N H|Cantarini, Mireille V|van der Graaf, Winette T A|Oyen, Wim J G
PMID: 23372439
Journal: Yao Xue Xue Bao. 2012 Dec;47(12):1567-74.
Title: [Progress of anti-tumor study based on BRAF].
Author: Yan, Gui-Rui|Xu, Zhi-Jian|Wang, He-Yao|Zhu, Wei-Liang
PMID: 23460959
Journal: Oncogene. 2013 Jan 31;32(5):564-76.
Title: Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway promotes expression of dual-specificity phosphatase 4 (DUSP4/MKP2) resulting in nuclear ERK1/2 inhibition.
Author: Cagnol, S|Rivard, N
PMID: 22430215
Journal: Int J Cancer. 2013 Feb 1;132(3):E149-57.
Title: Mitogen-activated protein kinase (MEK/ERK) inhibition sensitizes cancer cells to centromere-associated protein E inhibition.
Author: Mayes, Patrick A|Degenhardt, Yan Y|Wood, Andrew|Toporovskya, Yana|Diskin, Sharon J|Haglund, Elizabeth|Moy, Christopher|Wooster, Richard|Maris, John M
PMID: 22948716
Journal: Int J Cancer. 2013 Apr 1;132(7):1537-46.
Title: Expression of the MAP kinase phosphatase DUSP4 is associated with microsatellite instability in colorectal cancer (CRC) and causes increased cell proliferation.
Author: Groschl, Benedikt|Bettstetter, Marcus|Giedl, Christian|Woenckhaus, Matthias|Edmonston, Tina|Hofstadter, Ferdinand|Dietmaier, Wolfgang
PMID: 22965873
Journal: J Nat Med. 2013 Jul;67(3):468-79.
Title: Synergistic anticancer activities of the plant-derived sesquiterpene lactones salograviolide A and iso-seco-tanapartholide.
Author: Salla, Mohamed|Fakhoury, Isabelle|Saliba, Najat|Darwiche, Nadine|Gali-Muhtasib, Hala
PMID: 22976170
Journal: Cancer Lett. 2013 Jan 1;328(1):73-82.
Title: Celecoxib induces proliferation and Amphiregulin production in colon subepithelial myofibroblasts, activating erk1-2 signaling in synergy with EGFR.
Author: Benelli, Roberto|Vene, Roberta|Minghelli, Simona|Carlone, Sebastiano|Gatteschi, Beatrice|Ferrari, Nicoletta
PMID: 23010081
Journal: J Cell Physiol. 2013 May;228(5):1017-24.
Title: Visfatin induces stromal cell-derived factor-1 expression by beta1 integrin signaling in colorectal cancer cells.
Author: Huang, Wen-Shih|Chen, Cheng-Nan|Sze, Chun-I|Teng, Chih-Chuan
PMID: 23042611
Journal: Oncogene. 2013 Sep 12;32(37):4343-54.
Title: Mesenchymal stem cells promote growth and angiogenesis of tumors in mice.
Author: Huang, W-H|Chang, M-C|Tsai, K-S|Hung, M-C|Chen, H-L|Hung, S-C
PMID: 23085755
Journal: Int J Biochem Cell Biol. 2013 Feb;45(2):243-54.
Title: EZH2 is regulated by ERK/AKT and targets integrin alpha2 gene to control Epithelial-Mesenchymal Transition and anoikis in colon cancer cells.
Author: Ferraro, Angelo|Mourtzoukou, Despoina|Kosmidou, Vivian|Avlonitis, Spiros|Kontogeorgos, George|Zografos, George|Pintzas, Alexander
PMID: 23116973
Journal: Oncol Rep. 2013 Feb;29(2):535-40.
Title: Critical role of aquaporin-3 in epidermal growth factor-induced migration of colorectal carcinoma cells and its clinical significance.
Author: Li, Ang|Lu, Dehong|Zhang, Yupeng|Li, Jia|Fang, Yu|Li, Fei|Sun, Jiabang
PMID: 23165320
Journal: Cancer Sci. 2013 Mar;104(3):328-36.
Title: Hedgehog Gli3 activator signal augments tumorigenicity of colorectal cancer via upregulation of adherence-related genes.
Author: Iwasaki, Hironori|Nakano, Kenji|Shinkai, Kentaro|Kunisawa, Yumi|Hirahashi, Minako|Oda, Yoshinao|Onishi, Hideya|Katano, Mitsuo
PMID: 23176625
Journal: J Biol Chem. 2013 Jan 25;288(4):2403-13.
Title: Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines.
Author: Vartanian, Steffan|Bentley, Carolyn|Brauer, Matthew J|Li, Li|Shirasawa, Senji|Sasazuki, Takehiko|Kim, Jung-Sik|Haverty, Pete|Stawiski, Eric|Modrusan, Zora|Waldman, Todd|Stokoe, David
PMID: 23188824
Journal: Cancer Lett. 2013 Apr 28;330(2):225-32.
Title: Nuclear factor-E2 (Nrf2) is regulated through the differential activation of ERK1/2 and PKC alpha/betaII by Gymnasterkoreayne B.
Author: Lee, Kyung-Mi|Kang, Kyungsu|Lee, Saet Byoul|Nho, Chu Won
PMID: 23219897
Journal: Int J Oncol. 2013 Feb;42(2):556-64.
Title: Extracellular signal-regulated kinase and Akt activation play a critical role in the process of hepatocyte growth factor-induced epithelial-mesenchymal transition.
Author: Tanahashi, Toshiyuki|Osada, Shinji|Yamada, Atsuko|Kato, Junko|Yawata, Kazunori|Mori, Ryutaro|Imai, Hisashi|Sasaki, Yoshiyuki|Saito, Shiro|Tanaka, Yoshihiro|Nonaka, Kenichi|Yoshida, Kazuhiro
PMID: 23229794
Journal: Mol Cancer Res. 2013 Feb;11(2):109-21.
Title: Knockdown of PAK4 or PAK1 inhibits the proliferation of mutant KRAS colon cancer cells independently of RAF/MEK/ERK and PI3K/AKT signaling.
Author: Tabusa, Hana|Brooks, Teresa|Massey, Andrew J
PMID: 23233484
Journal: Biochem J. 2013 Mar 1;450(2):285-94.
Title: The BH3 mimetic ABT-263 synergizes with the MEK1/2 inhibitor selumetinib/AZD6244 to promote BIM-dependent tumour cell death and inhibit acquired resistance.
Author: Sale, Matthew J|Cook, Simon J
PMID: 23234544
Journal: Cancer Res. 2013 Mar 15;73(6):1912-21.
Title: Mixed lineage kinase MLK4 is activated in colorectal cancers where it synergistically cooperates with activated RAS signaling in driving tumorigenesis.
Author: Martini, Miriam|Russo, Mariangela|Lamba, Simona|Vitiello, Elisa|Crowley, Emily Hannah|Sassi, Francesco|Romanelli, Davide|Frattini, Milo|Marchetti, Antonio|Bardelli, Alberto
PMID: 23319808
Journal: J Nucl Med. 2013 Mar;54(3):424-30.
Title: 3'-Deoxy-3'-18F-fluorothymidine PET predicts response to (V600E)BRAF-targeted therapy in preclinical models of colorectal cancer.
Author: McKinley, Eliot T|Smith, R Adam|Zhao, Ping|Fu, Allie|Saleh, Samir A|Uddin, Md Imam|Washington, M Kay|Coffey, Robert J|Manning, H Charles
PMID: 23341544
Journal: Biochim Biophys Acta. 2013 Jul;1834(7):1396-401.
Title: Quantitative NMR analysis of Erk activity and inhibition by U0126 in a panel of patient-derived colorectal cancer cell lines.
Author: Rose, Honor May|Stuiver, Marchel|Thongwichian, Rossukon|Theillet, Francois-Xavier|Feller, Stephan M|Selenko, Philipp
PMID: 23360766
Journal: Cancer Sci. 2013 May;104(5):604-10.
Title: Norcantharidin inhibits tumor angiogenesis via blocking VEGFR2/MEK/ERK signaling pathways.
Author: Zhang, Long|Ji, Qing|Liu, Xuan|Chen, Xingzhu|Chen, Zhaohua|Qiu, Yanyan|Sun, Jian|Cai, Jianfeng|Zhu, Huirong|Li, Qi
PMID: 23363445
Journal: J Agric Food Chem. 2013 Mar 20;61(11):2811-9.
Title: P27/Kip1 is responsible for magnolol-induced U373 apoptosis in vitro and in vivo.
Author: Chen, Li-Ching|Lee, Wen-Sen
PMID: 23448150
Journal: J Cancer Res Clin Oncol. 2013 Jun;139(6):953-61.
Title: KRAS allel-specific activity of sunitinib in an isogenic disease model of colorectal cancer.
Author: Modest, D P|Camaj, P|Heinemann, V|Schwarz, B|Jung, A|Laubender, R P|Gamba, S|Haertl, C|Stintzing, S|Primo, S|Bruns, C J
PMID: 23455880
Journal: BMC Complement Altern Med. 2013 Mar 18;13:65.
Title: A Chinese herbal formula, Yi-Qi-Fu-Sheng, inhibits migration/invasion of colorectal cancer by down-regulating MMP-2/9 via inhibiting the activation of ERK/MAPK signaling pathways.
Author: Deng, Wanli|Sui, Hua|Wang, Qiaolin|He, Nana|Duan, Chunyan|Han, Liang|Li, Qi|Lu, Ming|Lv, Shuqin
PMID: 23506655
Journal: Transl Oncol. 2013 Apr;6(2):124-32. Epub 2013 Apr 1.
Title: CXCR4 Expression and Treatment with SDF-1alpha or Plerixafor Modulate Proliferation and Chemosensitivity of Colon Cancer Cells.
Author: Heckmann, Doreen|Maier, Patrick|Laufs, Stephanie|Wenz, Frederik|Zeller, W Jens|Fruehauf, Stefan|Allgayer, Heike
PMID: 23544165
Journal: BMC Cancer. 2013 Apr 1;13:169.
Title: High resolution melting analysis of KRAS, BRAF and PIK3CA in KRAS exon 2 wild-type metastatic colorectal cancer.
Author: Guedes, Joana G|Veiga, Isabel|Rocha, Patricia|Pinto, Pedro|Pinto, Carla|Pinheiro, Manuela|Peixoto, Ana|Fragoso, Maria|Raimundo, Ana|Ferreira, Paula|Machado, Manuela|Sousa, Nuno|Lopes, Paula|Araujo, Antonio|Macedo, Joana|Alves, Fernando|Coutinho, Camila|He
PMID: 23548132
Journal: J Clin Invest. 2013 Apr;123(4):1428-43.
Title: Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK.
Author: Neufert, Clemens|Becker, Christoph|Tureci, Ozlem|Waldner, Maximilian J|Backert, Ingo|Floh, Katharina|Atreya, Imke|Leppkes, Moritz|Jefremow, Andre|Vieth, Michael|Schneider-Stock, Regine|Klinger, Patricia|Greten, Florian R|Threadgill, David W|Sahin, Ugur|Ne
PMID: 23549083
Journal: J Cancer Res Clin Oncol. 2013 Jul;139(7):1169-78.
Title: Microarray analyses reveal liver metastasis-related genes in metastatic colorectal cancer cell model.
Author: Chen, Qiang|Chen, Lei|Zhao, Ren|Yang, Xiao-dong|Imran, Khan|Xing, Chun-gen
PMID: 23563852
Journal: Magy Onkol. 2013 Mar;57(1):56-62.
Title: [Biomarkers in solid tumors].
Author: Nagy, Zsuzsanna
PMID: 23573523
Journal: Evid Based Complement Alternat Med. 2013;2013:974313.
Title: Activation of AMP-Activated Protein Kinase alpha and Extracelluar Signal-Regulated Kinase Mediates CB-PIC-Induced Apoptosis in Hypoxic SW620 Colorectal Cancer Cells.
Author: Cho, Sung-Yun|Lee, Hyo-Jeong|Lee, Hyo-Jung|Jung, Deok-Beom|Kim, Hyunseok|Sohn, Eun Jung|Kim, Bonglee|Jung, Ji Hoon|Kwon, Byoung-Mog|Kim, Sung-Hoon
PMID: 23589723
Journal: Toxicol In Vitro. 2013 Sep;27(6):1626-33.
Title: Activation of ERK signaling and induction of colon cancer cell death by piperlongumine.
Author: Randhawa, H|Kibble, K|Zeng, H|Moyer, M P|Reindl, K M
PMID: 23603476
Journal: Proc Natl Acad Sci U S A. 2013 May 14;110(20):8182-7.
Title: In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction.
Author: Shima, Fumi|Yoshikawa, Yoko|Ye, Min|Araki, Mitsugu|Matsumoto, Shigeyuki|Liao, Jingling|Hu, Lizhi|Sugimoto, Takeshi|Ijiri, Yuichi|Takeda, Azusa|Nishiyama, Yuko|Sato, Chie|Muraoka, Shin|Tamura, Atsuo|Osoda, Tsutomu|Tsuda, Ken-ichiro|Miyakawa, Tomoya|Fukunis
PMID: 23630290
Journal: Oncol Rep. 2013 Jul;30(1):292-8.
Title: Ginseng saponin metabolite 20(S)-protopanaxadiol inhibits tumor growth by targeting multiple cancer signaling pathways.
Author: Gao, Jian-Li|Lv, Gui-Yuan|He, Bai-Cheng|Zhang, Bing-Qiang|Zhang, Hongyu|Wang, Ning|Wang, Chong-Zhi|Du, Wei|Yuan, Chun-Su|He, Tong-Chuan
PMID: 23633038
Journal: Mol Cell Endocrinol. 2013 Jul 15;374(1-2):101-7.
Title: Cholesterol affects gene expression of the Jun family in colon carcinoma cells using different signaling pathways.
Author: Scheinman, Eyal J|Rostoker, Ran|Leroith, Derek
PMID: 23643895
Journal: Int J Oncol. 2013 Jul;43(1):141-50.
Title: Dual inhibition of EGFR and c-Met kinase activation by MJ-56 reduces metastasis of HT29 human colorectal cancer cells.
Author: Chen, Hui-Jye|Jiang, Yi-Lin|Lin, Chung-Ming|Tsai, Shih-Chang|Peng, Shu-Fen|Fushiya, Shinji|Hour, Mann-Jen|Yang, Jai-Sing
PMID: 23677180
Journal: J Cell Biochem. 2013 Oct;114(10):2392-404.
Title: Biomarkers of sensitivity to potent and selective antitumor 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F203) in ovarian cancer.
Author: Callero, Mariana A|Luzzani, Gabriela A|De Dios, Diana O|Bradshaw, Tracey D|Perez, Andrea I Loaiza
PMID: 23696052
Journal: J Gastroenterol Hepatol. 2013 Oct;28(10):1616-23.
Title: Suppressive effect of RAS inhibitor manumycin A on aberrant crypt foci formation in the azoxymethane-induced rat colorectal carcinogenesis model.
Author: Tsuda, Miho|Okamoto, Koichi|Muguruma, Naoki|Sannomiya, Katsutaka|Nakagawa, Tadahiko|Miyamoto, Hiroshi|Kitamura, Shinji|Goji, Takahiro|Kimura, Tetsuo|Okahisa, Toshiya|Izumi, Keisuke|Takayama, Tetsuji
PMID: 23730936
Journal: PLoS One. 2013 May 30;8(5):e63872.
Title: Ursolic acid simultaneously targets multiple signaling pathways to suppress proliferation and induce apoptosis in colon cancer cells.
Author: Wang, Jingshu|Liu, Liqun|Qiu, Huijuan|Zhang, Xiaohong|Guo, Wei|Chen, Wangbing|Tian, Yun|Fu, Lingyi|Shi, Dingbo|Cheng, Jianding|Huang, Wenlin|Deng, Wuguo
PMID: 23737956
Journal: Technol Cancer Res Treat. 2013 Dec;12(6):537-43.
Title: Knockdown of protein phosphatase magnesium-dependent 1 (PPM1D) through lentivirus-mediated RNA silencing inhibits colorectal carcinoma cell proliferation.
Author: Yin, Hongzhuan|Yan, Zhaopeng|Liang, Yichao|Liu, Baolin|Su, Qi
PMID: 23745790
Journal: Anticancer Res. 2013 Jun;33(6):2499-508.
Title: Combination of CYP inhibitor with MEK/ERK inhibitor enhances the inhibitory effect on ERK in BRAF mutant colon cancer cells.
Author: Lim, Sun Min|Hwang, Jee Won|Ahn, Joong Bae|Bae, Soo Kyung|Park, Chan Hee|Kim, Ki-Yeol|Rha, Sun Young|Chung, Hyun Cheol|Roh, Jae Kyung|Shin, Sang Joon
PMID: 23749901
Journal: Mol Syst Biol. 2013;9:673.
Title: Network quantification of EGFR signaling unveils potential for targeted combination therapy.
Author: Klinger, Bertram|Sieber, Anja|Fritsche-Guenther, Raphaela|Witzel, Franziska|Berry, Leanne|Schumacher, Dirk|Yan, Yibing|Durek, Pawel|Merchant, Mark|Schafer, Reinhold|Sers, Christine|Bluthgen, Nils
PMID: 23752269
Journal: Int J Oncol. 2013 Aug;43(2):629-37.
Title: Phenethyl isothiocyanate suppresses EGF-stimulated SAS human oral squamous carcinoma cell invasion by targeting EGF receptor signaling.
Author: Chen, Hui-Jye|Lin, Chung-Ming|Lee, Chao-Ying|Shih, Nai-Chen|Amagaya, Sakae|Lin, Yung-Chang|Yang, Jai-Sing
PMID: 23754208
Journal: J Natl Cancer Inst. 2013 Jul 3;105(13):937-46.
Title: MyD88 in DNA repair and cancer cell resistance to genotoxic drugs.
Author: Kfoury, Alain|Le Corf, Katy|El Sabeh, Rana|Journeaux, Alexandra|Badran, Bassam|Hussein, Nader|Lebecque, Serge|Manie, Serge|Renno, Toufic|Coste, Isabelle
PMID: 23766530
Journal: Stem Cell Res. 2013 Sep;11(2):820-33.
Title: Fibronectin extra domain A (EDA) sustains CD133(+)/CD44(+) subpopulation of colorectal cancer cells.
Author: Ou, Juanjuan|Deng, Jia|Wei, Xing|Xie, Ganfeng|Zhou, Rongbin|Yu, Liqing|Liang, Houjie
PMID: 23811539
Journal: BMC Cancer. 2013 Jul 1;13:321.
Title: Overexpression of peptide deformylase in breast, colon, and lung cancers.
Author: Randhawa, Harsharan|Chikara, Shireen|Gehring, Drew|Yildirim, Tuba|Menon, Jyotsana|Reindl, Katie M
PMID: 23815882
Journal: PLoS One. 2013 Jul 3;8(7):e67583.
Title: Dabrafenib; preclinical characterization, increased efficacy when combined with trametinib, while BRAF/MEK tool combination reduced skin lesions.
Author: King, Alastair J|Arnone, Marc R|Bleam, Maureen R|Moss, Katherine G|Yang, Jingsong|Fedorowicz, Kelly E|Smitheman, Kimberly N|Erhardt, Joseph A|Hughes-Earle, Angela|Kane-Carson, Laurie S|Sinnamon, Robert H|Qi, Hongwei|Rheault, Tara R|Uehling, David E|Laquer
PMID: 23844038
Journal: Pharm Biol. 2013 Dec;51(12):1508-14.
Title: Cleome arabica leaf extract has anticancer properties in human cancer cells.
Author: Tigrine, Chafia|Bulzomi, Pamela|Leone, Stefano|Bouriche, Hamama|Kameli, Abdelkarim|Marino, Maria
PMID: 23862683
Journal: Mol Cell Biochem. 2013 Nov;383(1-2):179-89.
Title: APRIL depletion induces cell cycle arrest and apoptosis through blocking TGF-beta1/ERK signaling pathway in human colorectal cancer cells.
Author: Wang, Feng|Chen, Lin|Ni, Hongbin|Wang, Guihua|Ding, Weifeng|Cong, Hui|Ju, Shaoqing|Yang, Shumei|Wang, Huimin
PMID: 23867993
Journal: Int J Oncol. 2013 Oct;43(4):1235-43.
Title: Ursolic acid promotes colorectal cancer cell apoptosis and inhibits cell proliferation via modulation of multiple signaling pathways.
Author: Lin, Jiumao|Chen, Youqin|Wei, Lihui|Shen, Aling|Sferra, Thomas J|Hong, Zhenfeng|Peng, Jun
PMID: 23900560
Journal: Int J Oncol. 2013 Oct;43(4):1111-6.
Title: Cancer upregulated gene 2, a novel oncogene, enhances migration and drug resistance of colon cancer cells via STAT1 activation.
Author: Malilas, Waraporn|Koh, Sang Seok|Kim, Seokho|Srisuttee, Ratakorn|Cho, Il-Rae|Moon, Jeong|Yoo, Hwa-Seung|Oh, Sangtaek|Johnston, Randal N|Chung, Young-Hwa
PMID: 23917355
Journal: Mol Med Rep. 2013 Oct;8(4):973-8.
Title: High concentrations of pyridoxal stimulate the expression of IGFBP1 in HepG2 cells through upregulation of the ERK/cJun pathway.
Author: Zhang, Peipei|Suidasari, Sofya|Hasegawa, Tomomi|Yanaka, Noriyuki|Kato, Norihisa
PMID: 23942851
Journal: Cell Commun Signal. 2013 Aug 15;11:59.
Title: Activation state-dependent interaction between Galphaq subunits and the Fhit tumor suppressor.
Author: Zuo, Hao|Chan, Grace P W|Zhu, Jing|Yeung, Wendy W S|Chan, Anthony S L|Ammer, Hermann|Wong, Yung H
PMID: 23947369
Journal: Mol Cancer Ther. 2013 Oct;12(10):2121-34.
Title: Sorafenib overcomes irinotecan resistance in colorectal cancer by inhibiting the ABCG2 drug-efflux pump.
Author: Mazard, Thibault|Causse, Annick|Simony, Joelle|Leconet, Wilhem|Vezzio-Vie, Nadia|Torro, Adeline|Jarlier, Marta|Evrard, Alexandre|Del Rio, Maguy|Assenat, Eric|Martineau, Pierre|Ychou, Marc|Robert, Bruno|Gongora, Celine
PMID: 23960095
Journal: Eur J Cancer. 2013 Dec;49(18):3924-35.
Title: miR-133a represses tumour growth and metastasis in colorectal cancer by targeting LIM and SH3 protein 1 and inhibiting the MAPK pathway.
Author: Wang, Hui|An, Hongying|Wang, Bin|Liao, Qing|Li, Weidong|Jin, Xuejun|Cui, Shuzhong|Zhang, Yajie|Ding, Yanqing|Zhao, Liang
PMID: 23968734
Journal: Evid Based Complement Alternat Med. 2013;2013:541695.
Title: Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer.
Author: Chen, Chun-Chieh|Sureshbabul, Munisamy|Chen, Huei-Wen|Lin, Yu-Shuang|Lee, Jen-Yi|Hong, Qi-Sheng|Yang, Ya-Chien|Yu, Sung-Liang
PMID: 23970932
Journal: Oncotarget. 2013 Sep;4(9):1399-415.
Title: Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness.
Author: Siemens, Helge|Jackstadt, Rene|Kaller, Markus|Hermeking, Heiko
PMID: 24009080
Journal: Cancer Biol Ther. 2013 Nov;14(11):1059-67.
Title: Targeting the ERK pathway reduces liver metastasis of Smad4-inactivated colorectal cancer.
Author: Ai, Xi|Wu, Yanhui|Zhang, Wei|Zhang, Zhanguo|Jin, Guannan|Zhao, Jianping|Yu, Jingjing|Lin, Youzhi|Zhang, Wanguang|Liang, Huifang|Datta, Pran K|Zhang, Mingzhi|Zhang, Bixiang|Chen, Xiaoping
PMID: 24025354
Journal: Cell Death Dis. 2013 Sep 12;4:e801.
Title: Metastatic SW620 colon cancer cells are primed for death when detached and can be sensitized to anoikis by the BH3-mimetic ABT-737.
Author: Maamer-Azzabi, A|Ndozangue-Touriguine, O|Breard, J
PMID: 24030153
Journal: Clin Cancer Res. 2013 Nov 15;19(22):6219-29.
Title: Overcoming IGF1R/IR resistance through inhibition of MEK signaling in colorectal cancer models.
Author: Flanigan, Sara A|Pitts, Todd M|Newton, Timothy P|Kulikowski, Gillian N|Tan, Aik Choon|McManus, Martine C|Spreafico, Anna|Kachaeva, Maria I|Selby, Heather M|Tentler, John J|Eckhardt, S Gail|Leong, Stephen
PMID: 24045180
Journal: Toxicol In Vitro. 2013 Dec;27(8):2256-63.
Title: Nicotine increases survival in human colon cancer cells treated with chemotherapeutic drugs.
Author: Dinicola, Simona|Morini, Veronica|Coluccia, Pierpaolo|Proietti, Sara|D'Anselmi, Fabrizio|Pasqualato, Alessia|Masiello, Maria Grazia|Palombo, Alessandro|De Toma, Giorgio|Bizzarri, Mariano|Cucina, Alessandra
PMID: 24095863
Journal: J Clin Endocrinol Metab. 2013 Dec;98(12):E1909-17.
Title: Shikonin inhibits thyroid cancer cell growth and invasiveness through targeting major signaling pathways.
Author: Yang, Qi|Ji, Meiju|Guan, Haixia|Shi, Bingyin|Hou, Peng
PMID: 24106286
Journal: Cancer Res. 2013 Nov 15;73(22):6584-96.
Title: Soluble carcinoembryonic antigen activates endothelial cells and tumor angiogenesis.
Author: Bramswig, Kira H|Poettler, Marina|Unseld, Matthias|Wrba, Friedrich|Uhrin, Pavel|Zimmermann, Wolfgang|Zielinski, Christoph C|Prager, Gerald W
PMID: 24121495
Journal: Mol Cancer Ther. 2013 Dec;12(12):2640-50.
Title: Apigenin sensitizes colon cancer cells to antitumor activity of ABT-263.
Author: Shao, Huanjie|Jing, Kai|Mahmoud, Esraa|Huang, Haihong|Fang, Xianjun|Yu, Chunrong
PMID: 24126433
Journal: Transl Oncol. 2013 Oct 1;6(5):520-7. eCollection 2013.
Title: Ephrin b2 receptor and microsatellite status in lymph node-positive colon cancer survival.
Author: Drucker, Arik|Arnason, Thomas|Yan, Sen Rong|Aljawad, Mohammed|Thompson, Kara|Huang, Weei-Yuarn
PMID: 24151532
Journal: Evid Based Complement Alternat Med. 2013;2013:458075.
Title: A Type II Arabinogalactan from Anoectochilus formosanus for G-CSF Production in Macrophages and Leukopenia Improvement in CT26-Bearing Mice Treated with 5-Fluorouracil.
Author: Yang, Li-Chan|Lu, Ting-Jang|Lin, Wen-Chuan
PMID: 24191166
Journal: BMC Cancer. 2013 Nov 8;13:531.
Title: Activation of pro-oncogenic pathways in colorectal hyperplastic polyps.
Author: Do, Catherine|Bertrand, Claudine|Palasse, Julien|Delisle, Marie-Bernadette|Cohen-Jonathan-Moyal, Elizabeth|Seva, Catherine
PMID: 24209454
Journal: Anticancer Res. 2013 Nov;33(11):4855-65.
Title: Differential expression and prognostic role of selected genes in colorectal cancer patients.
Author: Pitule, Pavel|Vycital, Ondrej|Bruha, Jan|Novak, Petr|Hosek, Petr|Treska, Vladislav|Hlavata, Ivona|Soucek, Pavel|Kralickova, Milena|Liska, Vaclav
PMID: 24222123
Journal: Anticancer Res. 2013 Nov;33(11):5159-63.
Title: A9 region in EPHB2 mutation is frequent in tumors with microsatellite instability. Analysis of prognosis.
Author: Rafael, Sara|Vidaurreta, Marta|Veganzones, Silvia|De La Orden, Virgnia|Mediero, Beatriz|Gutierrez, Maria Luisa|Maestro, Maria Luisa
PMID: 24222164
Journal: PLoS One. 2013 Nov 18;8(11):e79335.
Title: CRF2 signaling is a novel regulator of cellular adhesion and migration in colorectal cancer cells.
Author: Ducarouge, Benjamin|Pelissier-Rota, Marjolaine|Laine, Michele|Cristina, Nadine|Vachez, Yvan|Scoazec, Jean-Yves|Bonaz, Bruno|Jacquier-Sarlin, Muriel
PMID: 24260200
Journal: J Transl Med. 2013 Nov 27;11:295.
Title: Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity.
Author: Zins, Karin|Gunawardhana, Sandun|Lucas, Trevor|Abraham, Dietmar|Aharinejad, Seyedhossein
PMID: 24279335
Journal: PLoS One. 2013 Nov 27;8(11):e81592.
Title: Anti-cancer activity of an osthole derivative, NBM-T-BMX-OS01: targeting vascular endothelial growth factor receptor signaling and angiogenesis.
Author: Yang, Hung-Yu|Hsu, Ya-Fen|Chiu, Pei-Ting|Ho, Shiau-Jing|Wang, Chi-Han|Chi, Chih-Chin|Huang, Yu-Han|Lee, Cheng-Feng|Li, Ying-Shiuan|Ou, George|Hsu, Ming-Jen
PMID: 24312323
Journal: Enzymes. 2013;33 Pt A:213-48.
Title: A two-hybrid approach to identify inhibitors of the RAS-RAF interaction.
Author: Khazak, Vladimir|Eyrisch, Susanne|Kato, Juran|Tamanoi, Fuyuhiko|Golemis, Erica A
PMID: 25033807
Journal: Enzymes. 2013;34 Pt. B:1-23.
Title: Discovery of small-molecule Ras inhibitors that display antitumor activity by interfering with Ras.GTP-effector interaction.
Author: Shima, Fumi|Yoshikawa, Yoko|Matsumoto, Shigeyuki|Kataoka, Tohru
PMID: 25034098
Journal: Mol Carcinog. 2014 Apr;53(4):253-63.
Title: Cellular location and expression of Na+, K+ -ATPase alpha subunits affect the anti-proliferative activity of oleandrin.
Author: Yang, Peiying|Cartwright, Carrie|Efuet, Ekem|Hamilton, Stanley R|Wistuba, Ignacio Ivan|Menter, David|Addington, Crandell|Shureiqi, Imad|Newman, Robert A
PMID: 23073998
Journal: Mol Carcinog. 2014 Feb;53 Suppl 1:E62-71.
Title: The molecular chaperone Cosmc enhances malignant behaviors of colon cancer cells via activation of Akt and ERK.
Author: Huang, John|Che, Mei-Ieng|Lin, Neng-Yu|Hung, Ji-Shiang|Huang, Yu-Ting|Lin, Wei-Chou|Huang, Hsiu-Chin|Lee, Po-Huang|Liang, Jin-Tung|Huang, Min-Chuan
PMID: 23390052
Journal: Oncogene. 2014 Apr 3;33(14):1828-39.
Title: ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer.
Author: Ye, Q|Cai, W|Zheng, Y|Evers, B M|She, Q-B
PMID: 23624914
Journal: Gut. 2014 Apr;63(4):622-34.
Title: Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch-signalling.
Author: Pope, Jillian L|Bhat, Ajaz A|Sharma, Ashok|Ahmad, Rizwan|Krishnan, Moorthy|Washington, Mary K|Beauchamp, Robert D|Singh, Amar B|Dhawan, Punita
PMID: 23766441
Journal: Carcinogenesis. 2014 Jan;35(1):227-36.
Title: Female-specific rectal carcinogenesis in cyclin D1b transgenic mice.
Author: Kim, Chul Jang|Tambe, Yukihiro|Mukaisho, Ken-Ichi|Sugihara, Hiroyuki|Isono, Takahiro|Sonoda, Hiromichi|Shimizu, Tomoharu|Kondoh, Gen|Inoue, Hirokazu
PMID: 23975835
Journal: Mol Carcinog. 2014 Feb;53 Suppl 1:E119-29.
Title: N-acetyl-L-cysteine enhances fisetin-induced cytotoxicity via induction of ROS-independent apoptosis in human colonic cancer cells.
Author: Wu, Ming-Shun|Lien, Gi-Shih|Shen, Shing-Chuan|Yang, Liang-Yo|Chen, Yen-Chou
PMID: 24019108
Journal: Carcinogenesis. 2014 Feb;35(2):282-91.
Title: SDF-1/CXCR4 axis promotes directional migration of colorectal cancer cells through upregulation of integrin alphavbeta6.
Author: Wang, Ben|Wang, Wenke|Niu, Weibo|Liu, Enyu|Liu, Xiangjuan|Wang, Jiayong|Peng, Cheng|Liu, Song|Xu, Ling|Wang, Lei|Niu, Jun
PMID: 24085800
Journal: J Gastroenterol. 2014 Oct;49(10):1378-91.
Title: Functions and regulation of MUC13 mucin in colon cancer cells.
Author: Gupta, Brij K|Maher, Diane M|Ebeling, Mara C|Stephenson, Phillip D|Puumala, Susan E|Koch, Michael R|Aburatani, Hiroyuki|Jaggi, Meena|Chauhan, Subhash C
PMID: 24097071
Journal: Mol Cancer Res. 2014 Feb;12(2):228-38.
Title: The metalloprotease ADAMTS8 displays antitumor properties through antagonizing EGFR-MEK-ERK signaling and is silenced in carcinomas by CpG methylation.
Author: Choi, Gigi C G|Li, Jisheng|Wang, Yajun|Li, Lili|Zhong, Lan|Ma, Brigette|Su, Xianwei|Ying, Jianming|Xiang, Tingxiu|Rha, Sun Young|Yu, Jun|Sung, Joseph J Y|Tsao, Sai Wah|Chan, Anthony T C|Tao, Qian
PMID: 24184540
Journal: Dig Dis Sci. 2014 Mar;59(3):598-606.
Title: PAX6, a novel target of microRNA-7, promotes cellular proliferation and invasion in human colorectal cancer cells.
Author: Li, Yanwen|Li, Yuehui|Liu, Yanhong|Xie, Pingli|Li, Feng|Li, Guancheng
PMID: 24185687
Journal: Integr Cancer Ther. 2014 May;13(3):240-8.
Title: Scutellaria Barbata D Don Inhibits Colorectal Cancer Growth via Suppression of Multiple Signaling Pathways.
Author: Lin, Jiumao|Chen, Youqin|Cai, Qiaoyan|Wei, Lihui|Zhan, Youzhi|Shen, Aling|Sferra, Thomas J|Peng, Jun
PMID: 24231788
Journal: Am J Physiol Gastrointest Liver Physiol. 2014 Jan 1;306(1):G27-36.
Title: Paeoniflorin abrogates DSS-induced colitis via a TLR4-dependent pathway.
Author: Zhang, Jingjing|Dou, Wei|Zhang, Eryun|Sun, Aning|Ding, Lili|Wei, Xiaohui|Chou, Guixin|Mani, Sridhar|Wang, Zhengtao
PMID: 24232001
Journal: Biochim Biophys Acta. 2014 Mar;1843(3):618-28.
Title: Disrupted interaction between CFTR and AF-6/afadin aggravates malignant phenotypes of colon cancer.
Author: Sun, Ting Ting|Wang, Yan|Cheng, Hong|Xiao, Hu Zhang|Xiang, Juan Juan|Zhang, Jie Ting|Yu, Siu Bun Sydney|Martin, Tracey Amanda|Ye, Lin|Tsang, Lai Ling|Jiang, Wen Guo|Xiaohua, Jiang|Chan, Hsiao Chang
PMID: 24373847
Journal: Int J Oncol. 2014 Mar;44(3):781-90.
Title: S100A6 stimulates proliferation and migration of colorectal carcinoma cells through activation of the MAPK pathways.
Author: Duan, Liang|Wu, Rui|Zou, Zhengyu|Wang, Haiyan|Ye, Liwei|Li, Huan|Yuan, Shimei|Li, Xueru|Zha, He|Sun, Hui|Zhang, Yunyuan|Chen, Xian|Zhou, Lan
PMID: 24378749
Journal: Int J Clin Oncol. 2014 Apr;19(2):211-9.
Title: Is biomarker research advancing in the era of personalized medicine for head and neck cancer?
Author: Yokota, Tomoya
PMID: 24442754
Journal: Biochem Pharmacol. 2014 Mar 15;88(2):150-7.
Title: Paris saponin VII inhibits growth of colorectal cancer cells through Ras signaling pathway.
Author: Li, Yuhua|Sun, Yang|Fan, Lei|Zhang, Feng|Meng, Jin|Han, Jin|Guo, Xin|Zhang, Dian|Zhang, Rong|Yue, Zhenggang|Mei, Qibing
PMID: 24462916
Journal: Curr Cancer Drug Targets. 2014;14(2):217-24.
Title: Cetuximab inhibits gastric cancer growth in vivo, independent of KRAS status.
Author: Shi, Min|Shi, Hailong|Ji, Jun|Cai, Qu|Chen, Xuehua|Yu, Yingyan|Liu, Bingya|Zhu, Zhenggang|Zhang, Jun
PMID: 24467518
Journal: Hepatology. 2014 Jun;59(6):2238-50.
Title: Functional genomics identified a novel protein tyrosine phosphatase receptor type F-mediated growth inhibition in hepatocarcinogenesis.
Author: Bera, Rabindranath|Chiou, Chih-Yung|Yu, Ming-Chin|Peng, Jei-Ming|He, Chung-Ru|Hsu, Chih-Yun|Huang, Hsiao-Ling|Ho, Uda Y|Lin, Shi-Ming|Lin, Yu-Jr|Hsieh, Sen-Yung
PMID: 24470239
Journal: Anticancer Agents Med Chem. 2014;14(7):1051-61.
Title: ent-kaurane diterpenoids from Croton tonkinensis induce apoptosis in colorectal cancer cells through the phosphorylation of JNK mediated by reactive oxygen species and dual-specificity JNK kinase MKK4.
Author: Thuong, Phuong Thien|Khoi, Nguyen Minh|Ohta, Saho|Shiota, Shinichiro|Kanta, Hironori|Takeuchi, Kenji|Ito, Fumiaki
PMID: 24476312
Journal: Gastroenterology. 2014 May;146(5):1301-12.e1-10.
Title: PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice.
Author: Li, Xin|Stevens, Payton D|Liu, Jianyu|Yang, Haihua|Wang, Wei|Wang, Chi|Zeng, Zheng|Schmidt, Micheal D|Yang, Mike|Lee, Eun Y|Gao, Tianyan
PMID: 24530606
Journal: World J Gastroenterol. 2014 Feb 28;20(8):2071-8.
Title: Chloride intracellular channel 1 regulates colon cancer cell migration and invasion through ROS/ERK pathway.
Author: Wang, Pan|Zeng, Yun|Liu, Tao|Zhang, Chao|Yu, Pei-Wu|Hao, Ying-Xue|Luo, Hua-Xin|Liu, Gang
PMID: 24587680
Journal: J Cell Biochem. 2014 Mar;115(3):464-75.
Title: Desacetyluvaricin induces S phase arrest in SW480 colorectal cancer cells through superoxide overproduction.
Author: Xue, Jun-Yi|Zhou, Guang-Xiong|Chen, Tianfeng|Gao, Si|Choi, Mei-Yuk|Wong, Yum-Shing
PMID: 24591255
Journal: J Gastroenterol Hepatol. 2014 Jun;29(6):1192-9.
Title: Distinct profile of HIF1alpha, PTCH, EphB2, or DNA repair protein expression and BRAF mutation in colorectal serrated adenoma.
Author: Morimoto, Takashi|Mitomi, Hiroyuki|Saito, Tsuyoshi|Takahashi, Michiko|Murakami, Takashi|Sakamoto, Naoto|Yao, Takashi|Watanabe, Sumio
PMID: 24612059
Journal: Biochem Biophys Res Commun. 2014 Apr 4;446(2):487-92.
Title: Interleukin-1alpha promotes extracellular shedding of syndecan-2 via induction of matrix metalloproteinase-7 expression.
Author: Kwon, Mi-Jung|Hong, Eunkyoung|Choi, Youngsil|Kang, Duk-Hee|Oh, Eok-Soo
PMID: 24613844
Journal: J Pineal Res. 2014 May;56(4):415-26.
Title: Melatonin reduces endothelin-1 expression and secretion in colon cancer cells through the inactivation of FoxO-1 and NF-kappabeta.
Author: Leon, Josefa|Casado, Jorge|Jimenez Ruiz, Sergio M|Zurita, Maria Sol|Gonzalez-Puga, Cristina|Rejon, Juan D|Gila, Ana|Munoz de Rueda, Paloma|Pavon, Esther J|Reiter, Russel J|Ruiz-Extremera, Angela|Salmeron, Javier
PMID: 24628039
Journal: Mol Cancer. 2014 Mar 14;13:58.
Title: Hypoxia differentially regulated CXCR4 and CXCR7 signaling in colon cancer.
Author: Romain, Benoit|Hachet-Haas, Muriel|Rohr, Serge|Brigand, Cecile|Galzi, Jean-Luc|Gaub, Marie-Pierre|Pencreach, Erwan|Guenot, Dominique
PMID: 24629239
Journal: Clin Cancer Res. 2014 May 15;20(10):2793-804.
Title: A pharmacodynamic/pharmacokinetic study of ficlatuzumab in patients with advanced solid tumors and liver metastases.
Author: Tabernero, Josep|Elez, Maria Elena|Herranz, Maria|Rico, Isabel|Prudkin, Ludmila|Andreu, Jordi|Mateos, Jose|Carreras, Maria Josep|Han, May|Gifford, James|Credi, Marc|Yin, Wei|Agarwal, Shefali|Komarnitsky, Philip|Baselga, Jose
PMID: 24634378
Journal: Mol Cancer Ther. 2014 May;13(5):1345-55.
Title: ERBB3/HER2 signaling promotes resistance to EGFR blockade in head and neck and colorectal cancer models.
Author: Zhang, Li|Castanaro, Carla|Luan, Bo|Yang, Katie|Fan, Liangfen|Fairhurst, Jeanette L|Rafique, Ashique|Potocky, Terra B|Shan, Jing|Delfino, Frank J|Shi, Ergang|Huang, Tammy|Martin, Joel H|Chen, Gang|Macdonald, Douglas|Rudge, John S|Thurston, Gavin|Daly, Chr
PMID: 24634416
Journal: Mol Cancer Ther. 2014 May;13(5):1130-41.
Title: Protein kinase d as a potential chemotherapeutic target for colorectal cancer.
Author: Wei, Ning|Chu, Edward|Wipf, Peter|Schmitz, John C
PMID: 24634417
Journal: PLoS One. 2014 Mar 21;9(3):e88950.
Title: Widespread FRA1-dependent control of mesenchymal transdifferentiation programs in colorectal cancer cells.
Author: Diesch, Jeannine|Sanij, Elaine|Gilan, Omer|Love, Christopher|Tran, Hoanh|Fleming, Nicholas I|Ellul, Jason|Amalia, Marcia|Haviv, Izhak|Pearson, Richard B|Tulchinsky, Eugene|Mariadason, John M|Sieber, Oliver M|Hannan, Ross D|Dhillon, Amardeep S
PMID: 24658684
Journal: J Clin Endocrinol Metab. 2014 Jul;99(7):E1163-72.
Title: ZIC1 is a putative tumor suppressor in thyroid cancer by modulating major signaling pathways and transcription factor FOXO3a.
Author: Qiang, Wei|Zhao, Yuan|Yang, Qi|Liu, Wei|Guan, Haixia|Lv, Siqing|Ji, Meiju|Shi, Bingyin|Hou, Peng
PMID: 24684457
Journal: Oncol Rep. 2014 Jun;31(6):2493-8.
Title: Leptin-induced adhesion and invasion in colorectal cancer cell lines.
Author: Yoon, Kyung-Won|Park, Seon-Young|Kim, Ji-Young|Lee, Su-Mi|Park, Chang-Hwan|Cho, Sung-Bum|Lee, Wan-Sik|Joo, Young-Eun|Lee, Jae-Hyuk|Kim, Hyun-Soo|Choi, Sung-Kyu|Rew, Jong-Sun
PMID: 24700392
Journal: BMC Cancer. 2014 Apr 4;14:240.
Title: Met receptor-induced Grb2 or Shc signals both promote transformation of intestinal epithelial cells, albeit they are required for distinct oncogenic functions.
Author: Pomerleau, Veronique|Landry, Melissa|Bernier, Jimmy|Vachon, Pierre H|Saucier, Caroline
PMID: 24708867
Journal: Carcinogenesis. 2014 Jul;35(7):1661-70.
Title: Endothelial cell-derived fibronectin extra domain A promotes colorectal cancer metastasis via inducing epithelial-mesenchymal transition.
Author: Ou, Juanjuan|Peng, Yuan|Deng, Jia|Miao, Hongming|Zhou, Jie|Zha, Lin|Zhou, Rongbin|Yu, Liqing|Shi, Hang|Liang, Houjie
PMID: 24743511
Journal: Recent Results Cancer Res. 2014;201:215-25.
Title: Vemurafenib.
Author: Garbe, Claus|Abusaif, Sail|Eigentler, Thomas K
PMID: 24756795
Journal: Clin Cancer Res. 2014 Jul 1;20(13):3472-84.
Title: Regorafenib inhibits colorectal tumor growth through PUMA-mediated apoptosis.
Author: Chen, Dongshi|Wei, Liang|Yu, Jian|Zhang, Lin
PMID: 24763611
Journal: Mol Cancer. 2014 Apr 29;13:95.
Title: SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1.
Author: Qu, Yingying|Chen, Qin|Lai, Xueping|Zhu, Changhong|Chen, Cheng|Zhao, Xian|Deng, Rong|Xu, Ming|Yuan, Haihua|Wang, Yanli|Yu, Jianxiu|Huang, Jian
PMID: 24775912
Journal: Biochim Biophys Acta. 2014 Aug;1840(8):2651-61.
Title: EGFR and HER2 exert distinct roles on colon cancer cell functional properties and expression of matrix macromolecules.
Author: Ellina, Maria-Ioanna|Bouris, Panagiotis|Aletras, Alexios J|Theocharis, Achilleas D|Kletsas, Dimitris|Karamanos, Nikos K
PMID: 24792576
Journal: Tumour Biol. 2014 Sep;35(9):8639-43.
Title: Nrdp1 inhibits growth of colorectal cancer cells by nuclear retention of p27.
Author: Lu, Hang|Li, Hua|Mao, Dong|Zhu, Zhitu|Sun, Hongzhi
PMID: 24867101
Journal: Mol Oncol. 2014 Sep 12;8(6):1084-94.
Title: Acquired resistance to EGFR-targeted therapies in colorectal cancer.
Author: Van Emburgh, Beth O|Sartore-Bianchi, Andrea|Di Nicolantonio, Federica|Siena, Salvatore|Bardelli, Alberto
PMID: 24913799
Journal: J Biol Chem. 2014 Aug 8;289(32):22268-83.
Title: Differential regulation of cyclin D1 expression by protein kinase C alpha and signaling in intestinal epithelial cells.
Author: Pysz, Marybeth A|Hao, Fang|Hizli, A Asli|Lum, Michelle A|Swetzig, Wendy M|Black, Adrian R|Black, Jennifer D
PMID: 24914206
Journal: Clin Cancer Res. 2014 Dec 15;20(24):6429-38.
Title: TGFalpha and amphiregulin paracrine network promotes resistance to EGFR blockade in colorectal cancer cells.
Author: Hobor, Sebastijan|Van Emburgh, Beth O|Crowley, Emily|Misale, Sandra|Di Nicolantonio, Federica|Bardelli, Alberto
PMID: 24916700
Journal: Cell Rep. 2014 Jun 26;7(6):1940-55.
Title: ADAM17-dependent c-MET-STAT3 signaling mediates resistance to MEK inhibitors in KRAS mutant colorectal cancer.
Author: Van Schaeybroeck, Sandra|Kalimutho, Murugan|Dunne, Philip D|Carson, Robbie|Allen, Wendy|Jithesh, Puthen V|Redmond, Keara L|Sasazuki, Takehiko|Shirasawa, Senji|Blayney, Jaine|Michieli, Paolo|Fenning, Cathy|Lenz, Heinz-Josef|Lawler, Mark|Longley, Daniel B|J
PMID: 24931611
Journal: Clin Cancer Res. 2014 Aug 15;20(16):4251-61.
Title: Phase I expansion and pharmacodynamic study of the oral MEK inhibitor RO4987655 (CH4987655) in selected patients with advanced cancer with RAS-RAF mutations.
Author: Zimmer, Lisa|Barlesi, Fabrice|Martinez-Garcia, Maria|Dieras, Veronique|Schellens, Jan H M|Spano, Jean-Philippe|Middleton, Mark R|Calvo, Emiliano|Paz-Ares, Luiz|Larkin, James|Pacey, Simon|Venturi, Miro|Kraeber-Bodere, Francoise|Tessier, Jean J L|Eberhardt,
PMID: 24947927
Journal: Oncotarget. 2014 May 30;5(10):3220-33.
Title: RAGE mediates S100A4-induced cell motility via MAPK/ERK and hypoxia signaling and is a prognostic biomarker for human colorectal cancer metastasis.
Author: Dahlmann, Mathias|Okhrimenko, Anna|Marcinkowski, Patrick|Osterland, Marc|Herrmann, Pia|Smith, Janice|Heizmann, Claus W|Schlag, Peter M|Stein, Ulrike
PMID: 24952599
Journal: PLoS One. 2014 Jun 26;9(6):e98515.
Title: FGFR2 is amplified in the NCI-H716 colorectal cancer cell line and is required for growth and survival.
Author: Mathur, Anjili|Ware, Christopher|Davis, Lenora|Gazdar, Adi|Pan, Bo-Sheng|Lutterbach, Bart
PMID: 24968263
Journal: Int J Oncol. 2014 Sep;45(3):995-1010.
Title: Enhanced anti-colorectal cancer effects of carfilzomib combined with CPT-11 via downregulation of nuclear factor-kappaB in vitro and in vivo.
Author: Tang, Weiwei|Su, Guangjian|Li, Jieyu|Liao, Jinrong|Chen, Shuping|Huang, Chuanzhong|Liu, Fang|Chen, Qiang|Ye, Yunbin
PMID: 24968890
Journal: Biomed Pharmacother. 2014 Jun;68(5):527-35.
Title: NF-kappaB signaling inhibition and anticancer activities of LLDT-246 on human colorectal cancer HCT-116 cells in vitro.
Author: Li, Meng|Wang, Xiu'e|Liu, Ming|Qi, Xin|Li, Jing
PMID: 24986326
Journal: Biochim Biophys Acta. 2014 Sep;1842(9):1823-9.
Title: Hyperphosphorylation of PP2A in colorectal cancer and the potential therapeutic value showed by its forskolin-induced dephosphorylation and activation.
Author: Cristobal, Ion|Rincon, Raul|Manso, Rebeca|Madoz-Gurpide, Juan|Carames, Cristina|del Puerto-Nevado, Laura|Rojo, Federico|Garcia-Foncillas, Jesus
PMID: 24997451
Journal: PLoS One. 2014 Jul 8;9(7):e101889.
Title: The study of a novel sorafenib derivative HLC-080 as an antitumor agent.
Author: Tang, Ke|Luo, Can|Li, Yan|Lu, Chenshu|Zhou, Wanqi|Huang, Haihong|Chen, Xiaoguang
PMID: 25004130
Journal: Oncol Lett. 2014 Aug;8(2):493-501.
Title: Progress of cancer research on astrocyte elevated gene-1/Metadherin (Review).
Author: Huang, Yong|Li, LE-Ping
PMID: 25009642
Journal: Am J Physiol Gastrointest Liver Physiol. 2014 Sep 15;307(6):G664-71.
Title: Differential cell growth/apoptosis behavior of 13-hydroxyoctadecadienoic acid enantiomers in a colorectal cancer cell line.
Author: Cabral, Marisol|Martin-Venegas, Raquel|Moreno, Juan Jose
PMID: 25035111
Journal: Int J Oncol. 2014 Oct;45(4):1649-57.
Title: Silencing of CXCR7 gene represses growth and invasion and induces apoptosis in colorectal cancer through ERK and beta-arrestin pathways.
Author: Li, Xin-Xiang|Zheng, Hong-Tu|Huang, Li-Yong|Shi, De-Bing|Peng, Jun-Jie|Liang, Lei|Cai, San-Jun
PMID: 25051350
Journal: J Cell Biochem. 2014 Dec;115(12):2133-45.
Title: Molecular mechanisms associated with PTHrP-induced proliferation of colon cancer cells.
Author: Martin, Maria Julia|Calvo, Natalia|de Boland, Ana Russo|Gentili, Claudia
PMID: 25053227
Journal: Mol Cancer Res. 2014 Nov;12(11):1655-62.
Title: DRO1 inactivation drives colorectal carcinogenesis in ApcMin/+ mice.
Author: Grill, Jessica I|Neumann, Jens|Herbst, Andreas|Hiltwein, Felix|Ofner, Andrea|Marschall, Maximilian K|Wolf, Eckhard|Kirchner, Thomas|Goke, Burkhard|Schneider, Marlon R|Kolligs, Frank T
PMID: 25053805
Journal: Mol Clin Oncol. 2014 Sep;2(5):725-730.
Title: Investigation of neurotrophic tyrosine kinase receptor 1 fusions and neurotrophic tyrosine kinase receptor family expression in non-small-cell lung cancer and sensitivity to AZD7451 in vitro.
Author: Tatematsu, Tsutomu|Sasaki, Hidefumi|Shimizu, Shigeki|Okuda, Katsuhiro|Shitara, Masayuki|Hikosaka, Yu|Moriyama, Satoru|Yano, Motoki|Brown, Jeffrey|Fujii, Yoshitaka
PMID: 25054037
Journal: Br J Pharmacol. 2014 Dec;171(24):5728-42.
Title: PPemd26, an anthraquinone derivative, suppresses angiogenesis via inhibiting VEGFR2 signalling.
Author: Huang, S W|Lien, J C|Kuo, S C|Huang, T F
PMID: 25091695
Journal: J Zhejiang Univ Sci B. 2014 Aug;15(8):701-12.
Title: Sunitinib mesylate inhibits proliferation of human colonic stromal fibroblasts in vitro and in vivo.
Author: Wang, Zhan-huai|Li, Qiong|Ruan, Shu-qin|Xiao, Qian|Liu, Yue|Hu, Ye-ting|Hu, Li-feng|Chen, Hai-yan|Zheng, Shu|Zhang, Su-zhan|Ding, Ke-feng
PMID: 25091988
Journal: Apoptosis. 2014 Oct;19(10):1532-44.
Title: Urokinase-type plasminogen activator receptor regulates apoptotic sensitivity of colon cancer HCT116 cell line to TRAIL via JNK-p53 pathway.
Author: Liu, Xiufeng|Qiu, Fan|Liu, Zhipeng|Lan, Yan|Wang, Kai|Zhou, Ping-Kun|Wang, Yao|Hua, Zi-Chun
PMID: 25113506
Journal: ScientificWorldJournal. 2014;2014:340271.
Title: Radixin enhances colon cancer cell invasion by increasing MMP-7 production via Rac1-ERK pathway.
Author: Jiang, Qi-Hong|Wang, Ai-Xiang|Chen, Yan
PMID: 25136657
Journal: Cancer Lett. 2014 Nov 28;354(2):245-53.
Title: Interleukin-8 promotes cell migration through integrin alphavbeta6 upregulation in colorectal cancer.
Author: Sun, Qi|Sun, Fengkai|Wang, Ben|Liu, Song|Niu, Weibo|Liu, Enyu|Peng, Cheng|Wang, Jiayong|Gao, Huijie|Liang, Benjia|Niu, Zhengchuan|Zou, Xueqing|Niu, Jun
PMID: 25150782
Journal: Am J Physiol Gastrointest Liver Physiol. 2014 Oct 1;307(7):G749-59.
Title: PDGF receptor-alpha promotes TGF-beta signaling in hepatic stellate cells via transcriptional and posttranscriptional regulation of TGF-beta receptors.
Author: Liu, Chunsheng|Li, Jiachu|Xiang, Xiaoyu|Guo, Luyang|Tu, Kangsheng|Liu, Qinghua|Shah, Vijay H|Kang, Ningling
PMID: 25169976
Journal: Mol Cancer. 2014 Aug 29;13:201.
Title: Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer.
Author: El-Baba, Chirine|Mahadevan, Vijayalakshmi|Fahlbusch, Fabian B|Mohan S, Suma|Rau, Tilman T|Gali-Muhtasib, Hala|Schneider-Stock, Regine
PMID: 25174975
Journal: Ann Oncol. 2014 Nov;25(11):2196-204.
Title: MiR-29c mediates epithelial-to-mesenchymal transition in human colorectal carcinoma metastasis via PTP4A and GNA13 regulation of beta-catenin signaling.
Author: Zhang, J X|Mai, S J|Huang, X X|Wang, F W|Liao, Y J|Lin, M C|Kung, H F|Zeng, Y X|Xie, D
PMID: 25193986
Journal: J Hematol Oncol. 2014 Sep 9;7:56.
Title: Mutated in colorectal cancer (MCC) is a novel oncogene in B lymphocytes.
Author: Edwards, Shanique K E|Baron, Jacqueline|Moore, Carissa R|Liu, Yan|Perlman, David H|Hart, Ronald P|Xie, Ping
PMID: 25200342
Journal: Cancer Res. 2014 Nov 15;74(22):6693-704.
Title: TRAP1 is involved in BRAF regulation and downstream attenuation of ERK phosphorylation and cell-cycle progression: a novel target for BRAF-mutated colorectal tumors.
Author: Condelli, Valentina|Piscazzi, Annamaria|Sisinni, Lorenza|Matassa, Danilo Swann|Maddalena, Francesca|Lettini, Giacomo|Simeon, Vittorio|Palladino, Giuseppe|Amoroso, Maria Rosaria|Trino, Stefania|Esposito, Franca|Landriscina, Matteo
PMID: 25239454
Journal: BMC Cancer. 2014 Sep 27;14:723.
Title: Implication of metastasis suppressor gene, Kiss-1 and its receptor Kiss-1R in colorectal cancer.
Author: Ji, Ke|Ye, Lin|Ruge, Fiona|Hargest, Rachel|Mason, Malcolm D|Jiang, Wen G
PMID: 25260785
Journal: Biochem Pharmacol. 2014 Dec 1;92(3):415-24.
Title: Platinum(IV) complex LA-12 exerts higher ability than cisplatin to enhance TRAIL-induced cancer cell apoptosis via stimulation of mitochondrial pathway.
Author: Jelinkova, Iva|Safarikova, Barbora|Vondalova Blanarova, Olga|Skender, Belma|Hofmanova, Jirina|Sova, Petr|Moyer, Mary Pat|Kozubik, Alois|Kolar, Zdenek|Ehrmann, Jiri|Hyrslova Vaculova, Alena
PMID: 25285768
Journal: Nat Commun. 2014 Oct 13;5:5191.
Title: Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X.
Author: Schulz, Eduard|Klampfl, Petra|Holzapfel, Stefanie|Janecke, Andreas R|Ulz, Peter|Renner, Wilfried|Kashofer, Karl|Nojima, Satoshi|Leitner, Anita|Zebisch, Armin|Wolfler, Albert|Hofer, Sybille|Gerger, Armin|Lax, Sigurd|Beham-Schmid, Christine|Steinke, Verena|
PMID: 25307848
Journal: Biomed Res Int. 2014;2014:568693.
Title: Biological and molecular effects of small molecule kinase inhibitors on low-passage human colorectal cancer cell lines.
Author: Lange, Falko|Franz, Benjamin|Maletzki, Claudia|Linnebacher, Michael|Huhns, Maja|Jaster, Robert
PMID: 25309914
Journal: Curr Mol Med. 2014;14(9):1126-38.
Title: Cholinergic receptors as target for cancer therapy in a systems medicine perspective.
Author: Russo, P|Del Bufalo, A|Milic, M|Salinaro, G|Fini, M|Cesario, A
PMID: 25324001
Journal: Monoclon Antib Immunodiagn Immunother. 2014 Oct;33(5):312-8.
Title: A8, an anti-uPA agonistic antibody, promotes metastasis of cancer cells via ERK pathway.
Author: Song, Hyunkeun|Lee, A-Young|Jung, Hana|Choi, Jae-Hyeog|Roh, Kughwan|Ha, Sungmin|Kim, Kwang-Dong|Bae, Ki-Beom|Kang, Mi Seon|Park, SungJae|Choi, Il-Whan|Seo, Su-Kil|Park, SaeGwang
PMID: 25357998
Journal: Cell Death Dis. 2014 Nov 6;5:e1510.
Title: Bortezomib enhances cancer cell death by blocking the autophagic flux through stimulating ERK phosphorylation.
Author: Kao, C|Chao, A|Tsai, C-L|Chuang, W-C|Huang, W-P|Chen, G-C|Lin, C-Y|Wang, T-H|Wang, H-S|Lai, C-H
PMID: 25375375
Journal: PLoS One. 2014 Nov 17;9(11):e113037.
Title: Dual pharmacological targeting of the MAP kinase and PI3K/mTOR pathway in preclinical models of colorectal cancer.
Author: Pitts, Todd M|Newton, Timothy P|Bradshaw-Pierce, Erica L|Addison, Rebecca|Arcaroli, John J|Klauck, Peter J|Bagby, Stacey M|Hyatt, Stephanie L|Purkey, Alicia|Tentler, John J|Tan, Aik Choon|Messersmith, Wells A|Eckhardt, S Gail|Leong, Stephen
PMID: 25401499
Journal: PLoS One. 2014 Dec 1;9(12):e113931.
Title: Distinct behaviour of sorafenib in experimental cachexia-inducing tumours: the role of STAT3.
Author: Toledo, Miriam|Penna, Fabio|Busquets, Silvia|Lopez-Soriano, Francisco J|Argiles, Josep M
PMID: 25436606
Journal: Biomed Pharmacother. 2014 Oct;68(8):1023-9.
Title: Upregulation of MAPK/Erk and PI3K/Akt pathways in ulcerative colitis-associated colon cancer.
Author: Setia, Shruti|Nehru, Bimla|Sanyal, Sankar Nath
PMID: 25443414
Journal: Oncotarget. 2014 Dec 15;5(23):11847-56.
Title: The anti-HER3 antibody patritumab abrogates cetuximab resistance mediated by heregulin in colorectal cancer cells.
Author: Kawakami, Hisato|Okamoto, Isamu|Yonesaka, Kimio|Okamoto, Kunio|Shibata, Kiyoko|Shinkai, Yume|Sakamoto, Haruka|Kitano, Michiko|Tamura, Takao|Nishio, Kazuto|Nakagawa, Kazuhiko
PMID: 25474137
Journal: Cancer Biol Ther. 2014;15(12):1646-57.
Title: Regulation of dimethyl-fumarate toxicity by proteasome inhibitors.
Author: Booth, Laurence|Cruickshanks, Nichola|Tavallai, Seyedmehrad|Roberts, Jane L|Peery, Matthew|Poklepovic, Andrew|Dent, Paul
PMID: 25482938
Journal: PLoS One. 2014 Dec 11;9(12):e115068.
Title: Comprehensive suppression of all apoptosis-induced proliferation pathways as a proposed approach to colorectal cancer prevention and therapy.
Author: Bordonaro, Michael|Drago, Eric|Atamna, Wafa|Lazarova, Darina L
PMID: 25500581
Journal: Immunity. 2014 Dec 18;41(6):1052-63.
Title: Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis.
Author: Wang, Kepeng|Kim, Min Kyoung|Di Caro, Giuseppe|Wong, Jerry|Shalapour, Shabnam|Wan, Jun|Zhang, Wei|Zhong, Zhenyu|Sanchez-Lopez, Elsa|Wu, Li-Wha|Taniguchi, Koji|Feng, Ying|Fearon, Eric|Grivennikov, Sergei I|Karin, Michael
PMID: 25526314
Journal: Int J Clin Exp Pathol. 2014 Oct 15;7(11):7432-41. eCollection 2014.
Title: Upregulation of CD147 promotes cell invasion, epithelial-to-mesenchymal transition and activates MAPK/ERK signaling pathway in colorectal cancer.
Author: Xu, Tao|Zhou, Mingliang|Peng, Lipan|Kong, Shuai|Miao, Ruizheng|Shi, Yulong|Sheng, Hongguang|Li, Leping
PMID: 25550778
Journal: Cancer Cell Microenviron. 2014;1(5).
Title: New insights into 4E-BP1-regulated translation in cancer progression and metastasis.
Author: Wang, Jun|Ye, Qing|She, Qing-Bai
PMID: 26005705
Journal: Acta Pharm Sin B. 2014 Apr;4(2):128-34.
Title: RasGAP-derived peptide GAP159 enhances cisplatin-induced cytotoxicity and apoptosis in HCT116 cells.
Author: Zhang, Hao|Zhang, Shenghua|He, Hongwei|Zhang, Caixia|Chen, Yi|Yu, Dongke|Chen, Jianhua|Shao, Rongguang
PMID: 26579374
Journal: Oncogene. 2015 Jan 22;34(4):531-6.
Title: A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity.
Author: Bajpe, P K|Prahallad, A|Horlings, H|Nagtegaal, I|Beijersbergen, R|Bernards, R
PMID: 24469059
Journal: Mol Carcinog. 2015 Sep;54(9):789-799.
Title: Autocrine fibroblast growth factor 18 signaling mediates Wnt-dependent stimulation of CD44-positive human colorectal adenoma cells.
Author: Koneczny, Inga|Schulenburg, Axel|Hudec, Xenia|Knofler, Martin|Holzmann, Klaus|Piazza, Gary|Reynolds, Robert|Valent, Peter|Marian, Brigitte
PMID: 24619956
Journal: Mol Carcinog. 2015 Oct;54(10):1205-13.
Title: Overexpression of DNAJB6 promotes colorectal cancer cell invasion through an IQGAP1/ERK-dependent signaling pathway.
Author: Zhang, Tong-Tong|Jiang, Yan-Yi|Shang, Li|Shi, Zhi-Zhou|Liang, Jian-Wei|Wang, Zheng|Zhang, Yu|Hao, Jia-Jie|Jia, Xue-Mei|Xu, Xin|Cai, Yan|Zhan, Qi-Min|Wang, Ming-Rong
PMID: 25044025
Journal: J Cell Physiol. 2015 Jul;230(7):1430-7.
Title: Interleukin-17 induces CC chemokine receptor 6 expression and cell migration in colorectal cancer cells.
Author: Chin, Chih-Chien|Chen, Cheng-Nan|Kuo, Hsing-Chun|Shi, Chung-Sheng|Hsieh, Meng Chiao|Kuo, Yi-Hung|Tung, Shui-Yi|Lee, Kam-Fai|Huang, Wen-Shih
PMID: 25201147
Journal: Mol Oncol. 2015 Feb;9(2):377-88.
Title: TNF-alpha promotes invasive growth through the MET signaling pathway.
Author: Bigatto, Viola|De Bacco, Francesca|Casanova, Elena|Reato, Gigliola|Lanzetti, Letizia|Isella, Claudio|Sarotto, Ivana|Comoglio, Paolo M|Boccaccio, Carla
PMID: 25306394
Journal: Cell Death Differ. 2015 May;22(5):779-89.
Title: Bcl-2 stabilization by paxillin confers 5-fluorouracil resistance in colorectal cancer.
Author: Wu, D-W|Huang, C-C|Chang, S-W|Chen, T-H|Lee, H
PMID: 25323586
Journal: Biochim Biophys Acta. 2015 Jan;1853(1):157-65.
Title: Glaucarubinone inhibits colorectal cancer growth by suppression of hypoxia-inducible factor 1alpha and beta-catenin via a p-21 activated kinase 1-dependent pathway.
Author: Huynh, Nhi|Beutler, John A|Shulkes, Arthur|Baldwin, Graham S|He, Hong
PMID: 25409929
Journal: Biochim Biophys Acta. 2015 Apr;1850(4):640-6.
Title: Spontaneously hyperactive MEK-Erk pathway mediates paradoxical facilitation of cell proliferation in mild hypoxia.
Author: Miyamoto, Licht|Yagi, Yuko|Hatano, Aya|Kawazoe, Kazuyoshi|Ishizawa, Keisuke|Minakuchi, Kazuo|Tomita, Shuhei|Tsuchiya, Koichiro
PMID: 25497211
Journal: Mol Cancer Ther. 2015 Feb;14(2):480-90.
Title: Identification of LY2510924, a novel cyclic peptide CXCR4 antagonist that exhibits antitumor activities in solid tumor and breast cancer metastatic models.
Author: Peng, Sheng-Bin|Zhang, Xiaoyi|Paul, Donald|Kays, Lisa M|Gough, Wendy|Stewart, Julie|Uhlik, Mark T|Chen, Qi|Hui, Yu-Hua|Zamek-Gliszczynski, Maciej J|Wijsman, John A|Credille, Kelly M|Yan, Liang Zeng
PMID: 25504752
Journal: Anticancer Drugs. 2015 Apr;26(4):371-8.
Title: Effect of KRAS exon 2 mutations on antitumor activity of afatinib and gefitinib.
Author: Gamba, Sebastian|Camaj, Peter|Heinemann, Volker|Laubender, Rudiger P|Wang, Yan|Zhao, Yue|Stintzing, Sebastian|Giessen, Clemens|Boeck, Stefan|Haertl, Christoph|Bruns, Christiane J|Modest, Dominik P
PMID: 25514114
Journal: Cancer Lett. 2015 Mar 28;358(2):200-209.
Title: Neuropilin-2 mediates lymphangiogenesis of colorectal carcinoma via a VEGFC/VEGFR3 independent signaling.
Author: Ou, Juan-Juan|Wei, Xing|Peng, Yuan|Zha, Lin|Zhou, Rong-Bin|Shi, Hang|Zhou, Qi|Liang, Hou-Jie
PMID: 25543087
Journal: Oncotarget. 2015 Mar 10;6(7):4745-56.
Title: The cytotoxic effects of regorafenib in combination with protein kinase D inhibition in human colorectal cancer cells.
Author: Wei, Ning|Chu, Edward|Wu, Shao-yu|Wipf, Peter|Schmitz, John C
PMID: 25544765
Journal: Mol Cancer Res. 2015 Apr;13(4):659-69.
Title: Reversal of Mutant KRAS-Mediated Apoptosis Resistance by Concurrent Noxa/Bik Induction and Bcl-2/Bcl-xL Antagonism in Colon Cancer Cells.
Author: Okamoto, Koichi|Zaanan, Aziz|Kawakami, Hisato|Huang, Shengbing|Sinicrope, Frank A
PMID: 25548100
Journal: Inflamm Bowel Dis. 2015 Feb;21(2):287-96.
Title: Overexpression of PAK1 promotes cell survival in inflammatory bowel diseases and colitis-associated cancer.
Author: Khare, Vineeta|Dammann, Kyle|Asboth, Mario|Krnjic, Anita|Jambrich, Manuela|Gasche, Christoph
PMID: 25569743
Journal: Cancer Prev Res (Phila). 2015 Mar;8(3):222-30.
Title: A phase IIa randomized, double-blind trial of erlotinib in inhibiting epidermal growth factor receptor signaling in aberrant crypt foci of the colorectum.
Author: Gillen, Daniel L|Meyskens, Frank L|Morgan, Timothy R|Zell, Jason A|Carroll, Robert|Benya, Richard|Chen, Wen-Pin|Mo, Allen|Tucker, Chris|Bhattacharya, Asmita|Huang, Zhiliang|Arcilla, Myra|Wong, Vanessa|Chung, Jinah|Gonzalez, Rachel|Rodriguez, Luz Maria|Sza
PMID: 25604134
Journal: Invest New Drugs. 2015 Jun;33(3):720-8.
Title: Biomarker-driven phase 2 study of MK-2206 and selumetinib (AZD6244, ARRY-142886) in patients with colorectal cancer.
Author: Do, Khanh|Speranza, Giovanna|Bishop, Rachel|Khin, Sonny|Rubinstein, Larry|Kinders, Robert J|Datiles, Manuel|Eugeni, Michelle|Lam, Michael H|Doyle, L Austin|Doroshow, James H|Kummar, Shivaani
PMID: 25637165
Journal: Oncol Rep. 2015 Apr;33(4):1579-84.
Title: Inhibitory effect of maple syrup on the cell growth and invasion of human colorectal cancer cells.
Author: Yamamoto, Tetsushi|Uemura, Kentaro|Moriyama, Kaho|Mitamura, Kuniko|Taga, Atsushi
PMID: 25647359
Journal: Anticancer Res. 2015 Feb;35(2):645-51.
Title: Potential anticancer properties and mechanisms of action of curcumin.
Author: Vallianou, Natalia G|Evangelopoulos, Angelos|Schizas, Nikos|Kazazis, Christos
PMID: 25667441
Journal: Oncotarget. 2015 Mar 10;6(7):5041-58.
Title: Advances in dynamic modeling of colorectal cancer signaling-network regions, a path toward targeted therapies.
Author: Tortolina, Lorenzo|Duffy, David J|Maffei, Massimo|Castagnino, Nicoletta|Carmody, Aimee M|Kolch, Walter|Kholodenko, Boris N|De Ambrosi, Cristina|Barla, Annalisa|Biganzoli, Elia M|Nencioni, Alessio|Patrone, Franco|Ballestrero, Alberto|Zoppoli, Gabriele|Verr
PMID: 25671297
Journal: Cancer Discov. 2015 Apr;5(4):358-67.
Title: Clinical Acquired Resistance to RAF Inhibitor Combinations in BRAF-Mutant Colorectal Cancer through MAPK Pathway Alterations.
Author: Ahronian, Leanne G|Sennott, Erin M|Van Allen, Eliezer M|Wagle, Nikhil|Kwak, Eunice L|Faris, Jason E|Godfrey, Jason T|Nishimura, Koki|Lynch, Kerry D|Mermel, Craig H|Lockerman, Elizabeth L|Kalsy, Anuj|Gurski, Joseph M Jr|Bahl, Samira|Anderka, Kristin|Green,
PMID: 25673644
Journal: J Med Chem. 2015 Mar 12;58(5):2452-64.
Title: Synthesis of CDDO-amino acid-nitric oxide donor trihybrids as potential antitumor agents against both drug-sensitive and drug-resistant colon cancer.
Author: Ai, Yong|Kang, Fenghua|Huang, Zhangjian|Xue, Xiaowen|Lai, Yisheng|Peng, Sixun|Tian, Jide|Zhang, Yihua
PMID: 25675144
Journal: Cancer Lett. 2015 May 28;361(1):22-32.
Title: CXCL8, overexpressed in colorectal cancer, enhances the resistance of colorectal cancer cells to anoikis.
Author: Xiao, You-Chuan|Yang, Zhi-Bin|Cheng, Xian-Shuo|Fang, Xing-Bao|Shen, Tao|Xia, Cui-Feng|Liu, Ping|Qian, Hai-Hua|Sun, Bin|Yin, Zheng-Feng|Li, Yun-Feng
PMID: 25687885
Journal: Tumour Biol. 2015 Jul;36(7):5641-8.
Title: AZD-4547 exerts potent cytostatic and cytotoxic activities against fibroblast growth factor receptor (FGFR)-expressing colorectal cancer cells.
Author: Yao, Ting-Jing|Zhu, Jin-Hai|Peng, De-Feng|Cui, Zhen|Zhang, Chao|Lu, Pei-hua
PMID: 25691251
Journal: Cancer Biol Ther. 2015;16(1):34-42.
Title: The preclinical evaluation of the dual mTORC1/2 inhibitor INK-128 as a potential anti-colorectal cancer agent.
Author: Li, Chen|Cui, Jian-Feng|Chen, Min-Bin|Liu, Chao-Ying|Liu, Feng|Zhang, Qian-De|Zou, Jian|Lu, Pei-Hua
PMID: 25692620
Journal: J Cell Physiol. 2015 Sep;230(9):2281-98.
Title: Nexavar/Stivarga and viagra interact to kill tumor cells.
Author: Tavallai, Mehrad|Hamed, Hossein A|Roberts, Jane L|Cruickshanks, Nichola|Chuckalovcak, John|Poklepovic, Andrew|Booth, Laurence|Dent, Paul
PMID: 25704960
Journal: Cancer Res. 2015 Apr 1;75(7):1423-32.
Title: Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem-like Cells in an Akt/Foxo3a/TRAIL-Dependent Manner.
Author: Prabhu, Varun V|Allen, Joshua E|Dicker, David T|El-Deiry, Wafik S
PMID: 25712124
Journal: Am J Pathol. 2015 Apr;185(4):1135-44.
Title: Methionine adenosyltransferase 2B-GIT1 complex serves as a scaffold to regulate Ras/Raf/MEK1/2 activity in human liver and colon cancer cells.
Author: Peng, Hui|Li, Tony W H|Yang, Heping|Moyer, Mary P|Mato, Jose M|Lu, Shelly C
PMID: 25794709
Journal: Int J Cancer. 2015 Oct 1;137(7):1560-73.
Title: Sialidase NEU3 contributes neoplastic potential on colon cancer cells as a key modulator of gangliosides by regulating Wnt signaling.
Author: Takahashi, Kohta|Hosono, Masahiro|Sato, Ikuro|Hata, Keiko|Wada, Tadashi|Yamaguchi, Kazunori|Nitta, Kazuo|Shima, Hiroshi|Miyagi, Taeko
PMID: 25810027
Journal: Anticancer Drugs. 2015 Jul;26(6):657-66.
Title: ERK-dependent phosphorylation of HSF1 mediates chemotherapeutic resistance to benzimidazole carbamates in colorectal cancer cells.
Author: Wales, Christina T K|Taylor, Frederick R|Higa, Allan T|McAllister, Harvey A|Jacobs, Aaron T
PMID: 25811962
Journal: Oncotarget. 2015 Apr 20;6(11):8698-708.
Title: Paxillin promotes colorectal tumor invasion and poor patient outcomes via ERK-mediated stabilization of Bcl-2 protein by phosphorylation at Serine 87.
Author: Huang, Chi-Chou|Wu, De-Wei|Lin, Po-Lin|Lee, Huei
PMID: 25826088
Journal: Acta Pharmacol Sin. 2015 Apr;36(4):517-27.
Title: Physalin B not only inhibits the ubiquitin-proteasome pathway but also induces incomplete autophagic response in human colon cancer cells in vitro.
Author: Ma, Yi-ming|Han, Wei|Li, Jia|Hu, Li-hong|Zhou, Yu-bo
PMID: 25832431
Journal: Cancer Discov. 2015 Apr;5(4):348-50.
Title: Old Habits Die Hard: Addiction of BRAF-Mutant Cancer Cells to MAP Kinase Signaling.
Author: Meador, Catherine B|Pao, William
PMID: 25847954
Journal: Cancer Sci. 2015 Jun;106(6):692-9.
Title: Antitumor activity of the MEK inhibitor trametinib on intestinal polyp formation in Apc(Delta716) mice involves stromal COX-2.
Author: Fujishita, Teruaki|Kajino-Sakamoto, Rie|Kojima, Yasushi|Taketo, Makoto Mark|Aoki, Masahiro
PMID: 25855137
Journal: Endocr Relat Cancer. 2015 Jun;22(3):455-64.
Title: Brain-derived neurotrophic factor regulates cell motility in human colon cancer.
Author: Huang, Ssu-Ming|Lin, Chingju|Lin, Hsiao-Yun|Chiu, Chien-Ming|Fang, Chia-Wei|Liao, Kuan-Fu|Chen, Dar-Ren|Yeh, Wei-Lan
PMID: 25876647
Journal: BMC Cancer. 2015 Apr 12;15:275.
Title: Loss of AF-6/afadin induces cell invasion, suppresses the formation of glandular structures and might be a predictive marker of resistance to chemotherapy in endometrial cancer.
Author: Yamamoto, Takuro|Mori, Taisuke|Sawada, Morio|Matsushima, Hiroshi|Ito, Fumitake|Akiyama, Makoto|Kitawaki, Jo
PMID: 25879875
Journal: BMC Cancer. 2015 Mar 27;15:189.
Title: NPC1L1 knockout protects against colitis-associated tumorigenesis in mice.
Author: He, Jianming|Shin, Hyunsu|Wei, Xing|Kadegowda, Anil Kumar G|Chen, Rui|Xie, Sandy Krystal
PMID: 25881076
Journal: BMC Cancer. 2015 Apr 8;15:240.
Title: HGUE-C-1 is an atypical and novel colon carcinoma cell line.
Author: Grasso, Silvina|Martinez-Lacaci, Isabel|Barbera, Victor Manuel|Castillejo, Adela|Soto, Jose Luis|Gallego-Plazas, Javier|Lopez-Riquelme, Natividad|Garcia-Morales, Pilar|Mata-Balaguer, Trinidad|Ferragut, Jose Antonio|Saceda, Miguel
PMID: 25885658
Journal: J Transl Med. 2015 Feb 12;13:57.
Title: Tumour pharmacodynamics and circulating cell free DNA in patients with refractory colorectal carcinoma treated with regorafenib.
Author: Wong, Andrea Li Ann|Lim, Joline Si Jing|Sinha, Arvind|Gopinathan, Anil|Lim, Robert|Tan, Chee-Seng|Soh, Thomas|Venkatesh, Sudhakar|Titin, Christina|Sapari, Nur Sabrina|Lee, Soo-Chin|Yong, Wei-Peng|Tan, David Shao Ping|Pang, Brendan|Wang, Ting-Ting|Zee, Yin
PMID: 25889309
Journal: Nutr J. 2015 Apr 1;14:31.
Title: Combined ginger extract & Gelam honey modulate Ras/ERK and PI3K/AKT pathway genes in colon cancer HT29 cells.
Author: Tahir, Analhuda Abdullah|Sani, Nur Fathiah Abdul|Murad, Noor Azian|Makpol, Suzana|Ngah, Wan Zurinah Wan|Yusof, Yasmin Anum Mohd
PMID: 25889965
Journal: BMC Cancer. 2015 Apr 17;15:301.
Title: Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an independent prognostic marker in wild-type KRAS metastatic colorectal cancer after colorectal liver metastasectomy.
Author: Chen, Kuen-Feng|Yen, Chueh-Chuan|Lin, Jen-Kou|Chen, Wei-Shone|Yang, Shung-Haur|Jiang, Jeng-Kai|Lan, Yuan-Tzu|Lin, Chun-Chi|Yu, Hui-Chuan|Hsu, Hui-Mei|Lin, Wen-Ling|Teng, Hao-Wei
PMID: 25896895
Journal: Br J Cancer. 2015 Apr 28;112(9):1480-90.
Title: MicroRNA-224 is associated with colorectal cancer progression and response to 5-fluorouracil-based chemotherapy by KRAS-dependent and -independent mechanisms.
Author: Amankwatia, E B|Chakravarty, P|Carey, F A|Weidlich, S|Steele, R J C|Munro, A J|Wolf, C R|Smith, G
PMID: 25919696
Journal: Mol Oncol. 2015 Aug;9(7):1434-46.
Title: KRAS and HRAS mutations confer resistance to MET targeting in preclinical models of MET-expressing tumor cells.
Author: Leiser, Dominic|Medova, Michaela|Mikami, Kei|Nisa, Lluis|Stroka, Deborah|Blaukat, Andree|Bladt, Friedhelm|Aebersold, Daniel M|Zimmer, Yitzhak
PMID: 25933688
Journal: Br J Pharmacol. 2015 Aug;172(15):3929-43.
Title: Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway.
Author: Xie, Xin|Zhao, Yu|Ma, Chun-Yan|Xu, Xiao-Ming|Zhang, Yan-Qiu|Wang, Chen-Guang|Jin, Jing|Shen, Xin|Gao, Jin-Lai|Li, Na|Sun, Zhi-Jie|Dong, De-Li
PMID: 25953698
Journal: Int J Mol Sci. 2015 May 7;16(5):10411-25.
Title: TCF4 Is a Molecular Target of Resveratrol in the Prevention of Colorectal Cancer.
Author: Jeong, Jin Boo|Lee, Jihye|Lee, Seong-Ho
PMID: 25961950
Journal: Am J Cancer Res. 2015 Jan 15;5(2):560-74. eCollection 2015.
Title: Prominin-1 (CD133, AC133) and dipeptidyl-peptidase IV (CD26) are indicators of infinitive growth in colon cancer cells.
Author: Grunt, Thomas W|Hebar, Alexandra|Laffer, Sylvia|Wagner, Renate|Peter, Barbara|Herrmann, Harald|Graf, Alexandra|Bilban, Martin|Posch, Martin|Hoermann, Gregor|Mayerhofer, Matthias|Eisenwort, Gregor|Zielinski, Christoph C|Selzer, Edgar|Valent, Peter
PMID: 25973297
Journal: Nat Cell Biol. 2015 Jun;17(6):804-15.
Title: RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth.
Author: Depeille, Philippe|Henricks, Linda M|van de Ven, Robert A H|Lemmens, Ed|Wang, Chih-Yang|Matli, Mary|Werb, Zena|Haigis, Kevin M|Donner, David|Warren, Robert|Roose, Jeroen P
PMID: 26005835
Journal: Oncotarget. 2015 Aug 21;6(24):20672-84.
Title: Identification of the interplay between SOX9 and S100P in the metastasis and invasion of colon carcinoma.
Author: Shen, Zhiyong|Deng, Haijun|Fang, Yuan|Zhu, Xianjun|Ye, Geng-Tai|Yan, Li|Liu, Hao|Li, Guoxin
PMID: 26009899
Journal: Oncotarget. 2015 Sep 8;6(26):22298-309.
Title: Targeting TRAP1 as a downstream effector of BRAF cytoprotective pathway: a novel strategy for human BRAF-driven colorectal carcinoma.
Author: Condelli, Valentina|Maddalena, Francesca|Sisinni, Lorenza|Lettini, Giacomo|Matassa, Danilo Swann|Piscazzi, Annamaria|Palladino, Giuseppe|Amoroso, Maria Rosaria|Esposito, Franca|Landriscina, Matteo
PMID: 26084290
Journal: Oncotarget. 2015 Aug 28;6(25):21655-74.
Title: Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels.
Author: Nam, Seo Hee|Kim, Doyeun|Lee, Mi-Sook|Lee, Doohyung|Kwak, Tae Kyoung|Kang, Minkyung|Ryu, Jihye|Kim, Hye-Jin|Song, Haeng Eun|Choi, Jungeun|Lee, Gyu-Ho|Kim, Sang-Yeob|Park, Song Hwa|Kim, Dae Gyu|Kwon, Nam Hoon|Kim, Tai Young|Thiery, Jean Paul|Kim, Sunghoon|
PMID: 26091349
Journal: Sci Rep. 2015 Jun 22;5:11541.
Title: Voltage-gated Na+ Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling.
Author: House, Carrie D|Wang, Bi-Dar|Ceniccola, Kristin|Williams, Russell|Simaan, May|Olender, Jacqueline|Patel, Vyomesh|Baptista-Hon, Daniel T|Annunziata, Christina M|Gutkind, J Silvio|Hales, Tim G|Lee, Norman H
PMID: 26096612
Journal: Mol Cancer. 2015 Jun 27;14:123.
Title: NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7.
Author: Banskota, Suhrid|Regmi, Sushil C|Kim, Jung-Ae
PMID: 26116564
Journal: Cancer Immunol Res. 2015 Nov;3(11):1227-35.
Title: IL10R2 Overexpression Promotes IL22/STAT3 Signaling in Colorectal Carcinogenesis.
Author: Khare, Vineeta|Paul, Gregor|Movadat, Oliver|Frick, Adrian|Jambrich, Manuela|Krnjic, Anita|Marian, Brigitte|Wrba, Friedrich|Gasche, Christoph
PMID: 26130064
Journal: Oncol Rep. 2015 Sep;34(3):1221-30.
Title: Suppression of KLF8 induces cell differentiation and sensitizes colorectal cancer to 5-fluorouracil.
Author: Shi, Xinpeng|Luo, Xiaoyong|Yan, Qingqing|Zhang, Wenjing|Wu, Yao|Zhang, Mengnan|Zhao, Jinjun|Peng, Ying|Chen, Ye|Zhang, Yali|Chen, Cunlong|Cheng, Tianming|Chen, Chudi|Liu, Side|Bai, Yang|Wang, Jide
PMID: 26133391
Journal: Int J Oncol. 2015 Sep;47(3):1034-42.
Title: Cortactin promotes colon cancer progression by regulating ERK pathway.
Author: Ni, Qing-Feng|Yu, Jia-Wei|Qian, Fei|Sun, Nai-Zhi|Xiao, Jian-Jia|Zhu, Jian-Wei
PMID: 26151562
Journal: Oncotarget. 2015 Jul 10;6(19):16902-11.
Title: ErbB-3 activation by NRG-1beta sustains growth and promotes vemurafenib resistance in BRAF-V600E colon cancer stem cells (CSCs).
Author: Prasetyanti, Pramudita R|Capone, Emily|Barcaroli, Daniela|D'Agostino, Daniela|Volpe, Silvia|Benfante, Antonina|van Hooff, Sander|Iacobelli, Valentina|Rossi, Cosmo|Iacobelli, Stefano|Medema, Jan Paul|De Laurenzi, Vincenzo|Sala, Gianluca
PMID: 26160848
Journal: J Biomed Sci. 2015 Jul 16;22:56.
Title: Role of Raf-kinase inhibitor protein in colorectal cancer and its regulation by hydroxycamptothecine.
Author: Nie, Fang|Cao, Jianguo|Tong, Jinlu|Zhu, Mingming|Gao, Yuan|Ran, Zhihua
PMID: 26177829
Journal: FEBS Lett. 2015 Aug 19;589(18):2388-93.
Title: The S100P/RAGE signaling pathway regulates expression of microRNA-21 in colon cancer cells.
Author: Mercado-Pimentel, Melania E|Onyeagucha, Benjamin C|Li, Qing|Pimentel, Angel C|Jandova, Jana|Nelson, Mark A
PMID: 26193421
Journal: Mol Cancer Ther. 2015 Oct;14(10):2187-97.
Title: BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers.
Author: Tang, Zhiyu|Yuan, Xi|Du, Rong|Cheung, Shing-Hu|Zhang, Guoliang|Wei, Jing|Zhao, Yuan|Feng, Yingcai|Peng, Hao|Zhang, Yi|Du, Yunguang|Hu, Xiaoxia|Gong, Wenfeng|Liu, Yong|Gao, Yajuan|Liu, Ye|Hao, Rui|Li, Shengjian|Wang, Shaohui|Ji, Jiafu|Zhang, Lianhai|Li, Sh
PMID: 26208524
Journal: Physiol Rep. 2015 Jul;3(7). pii: 3/7/e12417.
Title: Leukotriene D4-induced Caco-2 cell proliferation is mediated by prostaglandin E2 synthesis.
Author: Cabral, Marisol|Martin-Venegas, Raquel|Moreno, Juan J
PMID: 26216432
Journal: Acta Pharmacol Sin. 2015 Sep;36(9):1074-84.
Title: New benzimidazole acridine derivative induces human colon cancer cell apoptosis in vitro via the ROS-JNK signaling pathway.
Author: Chen, Kang|Chu, Bi-zhu|Liu, Feng|Li, Bin|Gao, Chun-mei|Li, Lu-lu|Sun, Qin-sheng|Shen, Zhi-fa|Jiang, Yu-yang
PMID: 26235743
Journal: J Biol Chem. 2015 Sep 25;290(39):23838-49.
Title: The Mutant KRAS Gene Up-regulates BCL-XL Protein via STAT3 to Confer Apoptosis Resistance That Is Reversed by BIM Protein Induction and BCL-XL Antagonism.
Author: Zaanan, Aziz|Okamoto, Koichi|Kawakami, Hisato|Khazaie, Khashayarsha|Huang, Shengbing|Sinicrope, Frank A
PMID: 26245900
Journal: Oncogenesis. 2015 Aug 10;4:e162.
Title: SPINK1 promotes colorectal cancer progression by downregulating Metallothioneins expression.
Author: Tiwari, R|Pandey, S K|Goel, S|Bhatia, V|Shukla, S|Jing, X|Dhanasekaran, S M|Ateeq, B
PMID: 26258891
Journal: Clin Cancer Res. 2015 Dec 15;21(24):5499-5510.
Title: MEK plus PI3K/mTORC1/2 Therapeutic Efficacy Is Impacted by TP53 Mutation in Preclinical Models of Colorectal Cancer.
Author: Garcia-Garcia, Celina|Rivas, Martin A|Ibrahim, Yasir H|Calvo, Maria Teresa|Gris-Oliver, Albert|Rodriguez, Olga|Grueso, Judit|Anton, Pilar|Guzman, Marta|Aura, Claudia|Nuciforo, Paolo|Jessen, Katti|Argiles, Guillem|Dienstmann, Rodrigo|Bertotti, Andrea|Truso
PMID: 26272063
Journal: J Cancer. 2015 Jul 15;6(9):825-31.
Title: Hypothesis: Obesity Is Associated with a Lower Mutation Threshold in Colon Cancer.
Author: Bordonaro, Michael|Lazarova, Darina
PMID: 26284133
Journal: PLoS One. 2015 Aug 28;10(8):e0136947.
Title: Roles of TLR/MyD88/MAPK/NF-kappaB Signaling Pathways in the Regulation of Phagocytosis and Proinflammatory Cytokine Expression in Response to E. faecalis Infection.
Author: Zou, Jun|Shankar, Nathan
PMID: 26317438
Journal: PLoS One. 2015 Sep 14;10(9):e0138336.
Title: ERBB3 Positively Correlates with Intestinal Stem Cell Markers but Marks a Distinct Non Proliferative Cell Population in Colorectal Cancer.
Author: Jarde, Thierry|Kass, Lisa|Staples, Margaret|Lescesen, Helen|Carne, Peter|Oliva, Karen|McMurrick, Paul J|Abud, Helen E
PMID: 26367378
Journal: Cancer Med. 2015 Dec;4(12):1798-808.
Title: Protein phosphatase methylesterase-1 (PME-1) expression predicts a favorable clinical outcome in colorectal cancer.
Author: Kaur, Amanpreet|Elzagheid, Adam|Birkman, Eva-Maria|Avoranta, Tuulia|Kytola, Ville|Korkeila, Eija|Syrjanen, Kari|Westermarck, Jukka|Sundstrom, Jari
PMID: 26377365
Journal: Oncotarget. 2015 Oct 20;6(32):33500-11.
Title: Prostaglandin E receptor 4 (EP4) promotes colonic tumorigenesis.
Author: Chang, Jian|Vacher, Jean|Yao, Bing|Fan, Xiaofeng|Zhang, Bixiang|Harris, Raymond C|Zhang, Ming-Zhi
PMID: 26378024
Journal: J Clin Oncol. 2015 Dec 1;33(34):4023-31.
Title: Combined BRAF and MEK Inhibition With Dabrafenib and Trametinib in BRAF V600-Mutant Colorectal Cancer.
Author: Corcoran, Ryan B|Atreya, Chloe E|Falchook, Gerald S|Kwak, Eunice L|Ryan, David P|Bendell, Johanna C|Hamid, Omid|Messersmith, Wells A|Daud, Adil|Kurzrock, Razelle|Pierobon, Mariaelena|Sun, Peng|Cunningham, Elizabeth|Little, Shonda|Orford, Keith|Motwani, Mo
PMID: 26392102
Journal: J Exp Clin Cancer Res. 2015 Oct 1;34:108.
Title: Cancer-related CD15/FUT4 overexpression decreases benefit to agents targeting EGFR or VEGF acting as a novel RAF-MEK-ERK kinase downstream regulator in metastatic colorectal cancer.
Author: Giordano, Guido|Febbraro, Antonio|Tomaselli, Eugenio|Sarnicola, Maria Lucia|Parcesepe, Pietro|Parente, Domenico|Forte, Nicola|Fabozzi, Alessio|Remo, Andrea|Bonetti, Andrea|Manfrin, Erminia|Ghasemi, Somayehsadat|Ceccarelli, Michele|Cerulo, Luigi|Bazzoni, F
PMID: 26427914
Journal: Oncotarget. 2015 Nov 3;6(34):35991-6002.
Title: Molecular mechanisms underlying the antitumor activity of (E)-N-hydroxy-3-(1-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroquinolin-6-yl)acry lamide in human colorectal cancer cells in vitro and in vivo.
Author: Chen, Chun-Han|Lee, Chia-Hwa|Liou, Jing-Ping|Teng, Che-Ming|Pan, Shiow-Lin
PMID: 26462017
Journal: Sci Rep. 2015 Oct 16;5:15239.
Title: Pterostilbine, an active component of blueberries, sensitizes colon cancer cells to 5-fluorouracil cytotoxicity.
Author: Tolba, Mai F|Abdel-Rahman, Sherif Z
PMID: 26472352
Journal: Biomed Res Int. 2015;2015:397563.
Title: Synergistic Inhibitory Effects of Cetuximab and Cisplatin on Human Colon Cancer Cell Growth via Inhibition of the ERK-Dependent EGF Receptor Signaling Pathway.
Author: Son, Dong Ju|Hong, Ji Eun|Ban, Jung Ok|Park, Ju Ho|Lee, Hye Lim|Gu, Sun Mi|Hwang, Jae Yeon|Jung, Myung Hee|Lee, Dong Won|Han, Sang-Bae|Hong, Jin Tae
PMID: 26491668
Journal: Mol Cancer. 2015 Oct 24;14:182.
Title: Activin and TGFbeta use diverging mitogenic signaling in advanced colon cancer.
Author: Bauer, Jessica|Ozden, Ozkan|Akagi, Naomi|Carroll, Timothy|Principe, Daniel R|Staudacher, Jonas J|Spehlmann, Martina E|Eckmann, Lars|Grippo, Paul J|Jung, Barbara
PMID: 26497569
Journal: Endocr J. 2015;62(12):1133-7.
Title: Effect of dapagliflozin on colon cancer cell [Rapid Communication].
Author: Saito, Tsugumichi|Okada, Shuichi|Yamada, Eijiro|Shimoda, Yoko|Osaki, Aya|Tagaya, Yuko|Shibusawa, Ryo|Okada, Junichi|Yamada, Masanobu
PMID: 26522271
Journal: Int J Clin Exp Med. 2015 Sep 15;8(9):14805-15. eCollection 2015.
Title: Anticolorectal cancer effects and pharmacokinetic application of 2, 2-Bis [4-(4-amino-3-hydroxyphenoxy) phenyl] adamantane.
Author: Yang, Po-Sheng|Wang, Jane-Jen|Tsai, Tung-Hu|Wang, Yea-Hwey|Jan, Woan-Ching|Cheng, Shih-Ping|Chi, Chin-Wen|Hsu, Yi-Chiung
PMID: 26628962
Journal: Am J Cancer Res. 2015 Sep 15;5(10):3085-97. eCollection 2015.
Title: Progranulin promotes colorectal cancer proliferation and angiogenesis through TNFR2/Akt and ERK signaling pathways.
Author: Yang, Dong|Wang, Lin-Lin|Dong, Tao-Tao|Shen, Yi-Hang|Guo, Xiao-Sun|Liu, Chuan-Yong|Liu, Jie|Zhang, Pei|Li, Juan|Sun, Yu-Ping
PMID: 26693061
Journal: J Recept Signal Transduct Res. 2016;36(1):21-5.
Title: Controversial effect on Erk activation of some cytotoxic drugs in human LOVO colon cancer cells.
Author: Jemel-Oualha, Ikram|Elloumi-Mseddi, Jihene|Beji, Abdelhamid|Hakim, Bochra|Aifa, Sami
PMID: 25343691
Journal: Histopathology. 2016 Mar;68(4):567-77.
Title: Distribution of intestinal stem cell markers in colorectal precancerous lesions.
Author: Jang, Bo Gun|Kim, Hye Sung|Kim, Kyung Ju|Rhee, Ye-Young|Kim, Woo Ho|Kang, Gyeong Hoon
PMID: 26212207
Journal: Tumour Biol. 2016 Feb;37(2):2353-63.
Title: Tubb3 regulation by the Erk and Akt signaling pathways: a mechanism involved in the effect of arginine ADP-ribosyltransferase 1 (Art1) on apoptosis of colon carcinoma CT26 cells.
Author: Xiao, Ming|Tang, Yi|Chen, Wen-Wen|Wang, Ya-Lan|Yang, Lian|Li, Xian|Song, Guang-Lin|Kuang, Jing
PMID: 26373733
Journal: Tumour Biol. 2016 Feb;37(2):2519-26.
Title: Lysophosphatidic acid induces both EGFR-dependent and EGFR-independent effects on DNA synthesis and migration in pancreatic and colorectal carcinoma cells.
Author: Tveteraas, Ingun Heiene|Aasrum, Monica|Brusevold, Ingvild Johnsen|Odegard, John|Christoffersen, Thoralf|Sandnes, Dagny
PMID: 26386720
Journal: Oncol Rep. 2016 Jan;35(1):205-10.
Title: Nicotine enhances invasion and metastasis of human colorectal cancer cells through the nicotinic acetylcholine receptor downstream p38 MAPK signaling pathway.
Author: Xiang, Tao|Fei, Rushan|Wang, Zhe|Shen, Zhonglei|Qian, Jing|Chen, Wenbin
PMID: 26530054
Journal: Int J Mol Med. 2016 Jan;37(1):126-32.
Title: Orexin A induces autophagy in HCT-116 human colon cancer cells through the ERK signaling pathway.
Author: Wen, Jing|Zhao, Yuyan|Guo, Lei
PMID: 26572581
Journal: Cancer Res. 2016 Feb 1;76(3):724-35.
Title: Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis.
Author: Marusiak, Anna A|Stephenson, Natalie L|Baik, Hayeon|Trotter, Eleanor W|Li, Yaoyong|Blyth, Karen|Mason, Susan|Chapman, Phil|Puto, Lorena A|Read, Jon A|Brassington, Claire|Pollard, Hannah K|Phillips, Chris|Green, Isabelle|Overman, Ross|Collier, Matthew|Test
PMID: 26637668
Journal: Clin Cancer Res. 2016 May 15;22(10):2368-76.
Title: A Phase I Study of the Safety, Pharmacokinetics, and Pharmacodynamics of Combination Therapy with Refametinib plus Sorafenib in Patients with Advanced Cancer.
Author: Adjei, Alex A|Richards, Donald A|El-Khoueiry, Anthony|Braiteh, Fadi|Becerra, Carlos H R|Stephenson, Joe J Jr|Hezel, Aram F|Sherman, Morris|Garbo, Lawrence|Leffingwell, Diane P|Iverson, Cory|Miner, Jeffrey N|Shen, Zancong|Yeh, Li-Tain|Gunawan, Sonny|Wilson
PMID: 26644411
Journal: Invest New Drugs. 2016 Apr;34(2):168-75.
Title: A phase I study of selumetinib (AZD6244/ARRY-142866), a MEK1/2 inhibitor, in combination with cetuximab in refractory solid tumors and KRAS mutant colorectal cancer.
Author: Deming, Dustin A|Cavalcante, Ludmila L|Lubner, Sam J|Mulkerin, Daniel L|LoConte, Noelle K|Eickhoff, Jens C|Kolesar, Jill M|Fioravanti, Suzanne|Greten, Tim F|Compton, Kathryn|Doyle, Austin G|Wilding, George|Duffy, Austin|Liu, Glenn
PMID: 26666244
Journal: Food Funct. 2016 Feb;7(2):843-54.
Title: A serine protease extracted from Trichosanthes kirilowii induces apoptosis via the PI3K/AKT-mediated mitochondrial pathway in human colorectal adenocarcinoma cells.
Author: Song, Li|Chang, Jiao|Li, Zhuoyu
PMID: 26673746
Journal: Cancer Res Treat. 2016 Jul;48(3):1141-53.
Title: Dexamethasone Inhibits TGF-beta1-Induced Cell Migration by Regulating the ERK and AKT Pathways in Human Colon Cancer Cells Via CYR61.
Author: Han, Sanghoon|Bui, Ngoc Thuy|Ho, Manh Tin|Kim, Young Mee|Cho, Moonjae|Shin, Dong Bok
PMID: 26693911
Journal: J Biol Chem. 2016 Feb 26;291(9):4589-602.
Title: p120RasGAP Protein Mediates Netrin-1 Protein-induced Cortical Axon Outgrowth and Guidance.
Author: Antoine-Bertrand, Judith|Duquette, Philippe M|Alchini, Ricardo|Kennedy, Timothy E|Fournier, Alyson E|Lamarche-Vane, Nathalie
PMID: 26710849
Journal: Cancer Med. 2016 Feb;5(2):248-55.
Title: Targeting the PI3K signaling pathway in KRAS mutant colon cancer.
Author: Hong, Suntaek|Kim, SoYoung|Kim, Hye Youn|Kang, Myunghee|Jang, Ho Hee|Lee, Won-Suk
PMID: 26715098
Journal: Tumour Biol. 2016 Jul;37(7):8811-24.
Title: Upregulation of CD44v6 contributes to acquired chemoresistance via the modulation of autophagy in colon cancer SW480 cells.
Author: Lv, Lin|Liu, Hai-Guang|Dong, Si-Yang|Yang, Fan|Wang, Qing-Xuan|Guo, Gui-Long|Pan, Yi-Fei|Zhang, Xiao-Hua
PMID: 26747179
Journal: Sci Rep. 2016 Jan 11;6:18949.
Title: BRAF V600E inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells.
Author: Sueda, Toshinori|Sakai, Daisuke|Kawamoto, Koichi|Konno, Masamitsu|Nishida, Naohiro|Koseki, Jun|Colvin, Hugh|Takahashi, Hidekazu|Haraguchi, Naotsugu|Nishimura, Junichi|Hata, Taishi|Takemasa, Ichiro|Mizushima, Tsunekazu|Yamamoto, Hirofumi|Satoh, Taroh|Doki,
PMID: 26750638
Journal: J Exp Clin Cancer Res. 2016 Jan 12;35:5.
Title: Gab2 facilitates epithelial-to-mesenchymal transition via the MEK/ERK/MMP signaling in colorectal cancer.
Author: Ding, Chenbo|Luo, Junmin|Li, Longmei|Li, Shanshan|Yang, Liwen|Pan, Hongfei|Liu, Qianyi|Qin, Huan|Chen, Chao|Feng, Jihong
PMID: 26754532
Journal: Mol Carcinog. 2016 Dec;55(12):2135-2155.
Title: A novel PI3K axis selective molecule exhibits potent tumor inhibition in colorectal carcinogenesis.
Author: Hussain, Aashiq|Qazi, Asif Khurshid|Mupparapu, Nagaraju|Kumar, Ashok|Mintoo, Mubashir Javeed|Mahajan, Girish|Sharma, Parduman Raj|Singh, Shashank Kumar|Bharate, Sandip B|Zargar, Mohmmad Afzal|Ahmed, Qazi Naveed|Mondhe, Dilip Manikrao|Vishwakarma, Ram A|Ha
PMID: 26764221
Journal: Oncotarget. 2016 Feb 23;7(8):9188-221.
Title: BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells.
Author: Goulielmaki, Maria|Koustas, Evangelos|Moysidou, Eirini|Vlassi, Margarita|Sasazuki, Takehiko|Shirasawa, Senji|Zografos, George|Oikonomou, Eftychia|Pintzas, Alexander
PMID: 26802026
Journal: Cell Oncol (Dordr). 2016 Jun;39(3):243-52.
Title: Biomarkers for the identification of precursor polyps of colorectal serrated adenocarcinomas.
Author: Garcia-Solano, Jose|Garcia-Solano, Maria Eulalia|Torres-Moreno, Daniel|Carbonell, Pablo|Trujillo-Santos, Javier|Perez-Guillermo, Miguel|Conesa-Zamora, Pablo
PMID: 26832730
Journal: Molecules. 2016 Jan 30;21(2):169.
Title: Chemopreventive and Therapeutic Effects of Edible Berries: A Focus on Colon Cancer Prevention and Treatment.
Author: Afrin, Sadia|Giampieri, Francesca|Gasparrini, Massimiliano|Forbes-Hernandez, Tamara Y|Varela-Lopez, Alfonso|Quiles, Jose L|Mezzetti, Bruno|Battino, Maurizio
PMID: 26840292
Journal: Cell Prolif. 2016 Feb;49(1):69-78.
Title: microRNA-497 inhibits invasion and metastasis of colorectal cancer cells by targeting vascular endothelial growth factor-A.
Author: Qiu, Yanyan|Yu, Hui|Shi, Xiaojing|Xu, Ke|Tang, Qingfeng|Liang, Bo|Hu, Songjiao|Bao, Yijie|Xu, Jianhua|Cai, Jie|Peng, Wen|Cao, Qin|Yin, Peihao
PMID: 26840372
Journal: Sci Rep. 2016 Feb 5;6:20500.
Title: Norcantharidin Suppresses Colon Cancer Cell Epithelial-Mesenchymal Transition by Inhibiting the alphavbeta6-ERK-Ets1 Signaling Pathway.
Author: Peng, Cheng|Li, Zequn|Niu, Zhengchuan|Niu, Wei|Xu, Zongquan|Gao, Huijie|Niu, Weibo|Wang, JiaYong|He, Zhaobin|Gao, Chao|Lin, Pengfei|Agrez, Michael|Zhang, Zongli|Niu, Jun
PMID: 26846153
Journal: Mol Med Rep. 2016 Mar;13(3):2536-42.
Title: Nitidine chloride inhibits proliferation and induces apoptosis in colorectal cancer cells by suppressing the ERK signaling pathway.
Author: Zhai, Huiyuan|Hu, Sanyuan|Liu, Tongxiang|Wang, Feng|Wang, Xixun|Wu, Guochang|Zhang, Yifei|Sui, Minghua|Liu, Huantao|Jiang, Lixin
PMID: 26847477
Journal: Sci Rep. 2016 Feb 5;6:20460.
Title: KCTD12 Regulates Colorectal Cancer Cell Stemness through the ERK Pathway.
Author: Li, Liping|Duan, Tingmei|Wang, Xin|Zhang, Ru-Hua|Zhang, Meifang|Wang, Suihai|Wang, Fen|Wu, Yuanzhong|Huang, Haojie|Kang, Tiebang
PMID: 26847701
Journal: PeerJ. 2016 Feb 11;4:e1683.
Title: Heat shock protein 90 is involved in the regulation of HMGA2-driven growth and epithelial-to-mesenchymal transition of colorectal cancer cells.
Author: Kao, Chun-Yu|Yang, Pei-Ming|Wu, Ming-Heng|Huang, Chi-Chen|Lee, Yi-Chao|Lee, Kuen-Haur
PMID: 26893968
Journal: Cancer Genomics Proteomics. 2016 Mar-Apr;13(2):141-50.
Title: GeneGazer: A Toolkit Integrating Two Pipelines for Personalized Profiling and Biosignature Identification.
Author: Luo, Ji-Dung|Chang, Yu-Jia|Chang, Chung-Ming|You, Jeng-Fu|Wei, Po-Li|Chiou, Chiuan-Chian
PMID: 26912804
Journal: Oncotarget. 2016 Mar 29;7(13):16349-61.
Title: AMPK-mediated up-regulation of mTORC2 and MCL-1 compromises the anti-cancer effects of aspirin.
Author: Gao, Mei|Kong, Qingbin|Hua, Hui|Yin, Yancun|Wang, Jiao|Luo, Ting|Jiang, Yangfu
PMID: 26918349
Journal: Asian Pac J Cancer Prev. 2016;17(2):743-8.
Title: Impact of Cellular Genetic Make-up on Colorectal Cancer Cell Lines Response to Ellagic Acid: Implications of Small Interfering RNA.
Author: Yousef, Amany I|El-Masry, Omar S|Abdel Mohsen, Mohamed A
PMID: 26925673
Journal: Oncotarget. 2016 Apr 12;7(15):20368-80.
Title: Antitumor effects of calgranulin B internalized in human colon cancer cells.
Author: Kim, Kun|Kim, Kyung-Hee|Roh, Kangsan|Yoo, Byong Chul|Ku, Ja-Lok|Shin, Young-Kyoung|Cho, Jae Youl|Kim, Minjae|Kwon, Myung-Hee|Goh, Sung Ho|Chang, Hee Jin|Oh, Jae Hwan
PMID: 26933915
Journal: Mol Cancer. 2016 Mar 8;15:22.
Title: ERK mediated upregulation of death receptor 5 overcomes the lack of p53 functionality in the diaminothiazole DAT1 induced apoptosis in colon cancer models: efficiency of DAT1 in Ras-Raf mutated cells.
Author: Thamkachy, Reshma|Kumar, Rohith|Rajasekharan, K N|Sengupta, Suparna
PMID: 26956619
Journal: Cell Cycle. 2016;15(4):506-18.
Title: Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation.
Author: Lochhead, Pamela A|Clark, Jonathan|Wang, Lan-Zhen|Gilmour, Lesley|Squires, Matthew|Gilley, Rebecca|Foxton, Caroline|Newell, David R|Wedge, Stephen R|Cook, Simon J
PMID: 26959608
Journal: Proteomics. 2016 May;16(10):1557-69.
Title: Mechanistic study of the anti-cancer effect of Gynostemma pentaphyllum saponins in the Apc(Min/+) mouse model.
Author: Tai, William Chi-Shing|Wong, Wing-Yan|Lee, Magnolia Muk-Lan|Chan, Brandon Dow|Lu, Cheng|Hsiao, Wen-Luan Wendy
PMID: 26970558
Journal: Cancer Genet. 2016 Apr;209(4):143-53.
Title: Analysis of the predictive efficiency of S100P on adverse prognosis and the pathogenesis of S100P-mediated invasion and metastasis of colon adenocarcinoma.
Author: Shen, Zhi-Yong|Fang, Yuan|Zhen, Li|Zhu, Xian-Jun|Chen, Hao|Liu, Hao|Jiang, Bo|Li, Guo-Xin|Deng, Hai-Jun
PMID: 26975699
Journal: Oncol Rep. 2016 Jun;35(6):3363-70.
Title: Harmine induces cell cycle arrest and mitochondrial pathway-mediated cellular apoptosis in SW620 cells via inhibition of the Akt and ERK signaling pathways.
Author: Liu, Jiming|Li, Qiang|Liu, Zhilong|Lin, Liuming|Zhang, Xiangqiang|Cao, Mingrong|Jiang, Jianwei
PMID: 27004568
Journal: Medicine (Baltimore). 2016 Apr;95(15):e3321.
Title: MicroRNA Expression Signatures Associated With BRAF-Mutated Versus KRAS-Mutated Colorectal Cancers.
Author: Choi, Yong Won|Song, Young Soo|Lee, Hyunwoo|Yi, Kijong|Kim, Young-Bae|Suh, Kwang Wook|Lee, Dakeun
PMID: 27082577
Journal: Cell Mol Immunol. 2016 Sep;13(5):688-99.
Title: Expression of the novel adipokine C1qTNF-related protein 4 (CTRP4) suppresses colitis and colitis-associated colorectal cancer in mice.
Author: Luo, Yang|Wu, Xiaotong|Ma, Zhuang|Tan, Weifeng|Wang, Lanlan|Na, Daxiang|Zhang, Guoying|Yin, Ang|Huang, He|Xia, Dan|Zhang, Yingmei|Shi, Xueying|Wang, Lu
PMID: 27086950
Journal: Oncotarget. 2016 May 17;7(20):29429-39.
Title: Pinin facilitated proliferation and metastasis of colorectal cancer through activating EGFR/ERK signaling pathway.
Author: Wei, Zhigang|Ma, Wenhui|Qi, Xiaolong|Zhu, Xianjun|Wang, Yutian|Xu, Zhuoluo|Luo, Jun|Wang, Da|Guo, Weihong|Li, Xiaomei|Xin, Sainan|Yu, Jiang|Li, Guoxin
PMID: 27107420
Journal: J Hum Genet. 2016 Aug;61(8):711-20.
Title: Claudin-7 indirectly regulates the integrin/FAK signaling pathway in human colon cancer tissue.
Author: Ding, Lei|Wang, Liyong|Sui, Leiming|Zhao, Huanying|Xu, Xiaoxue|Li, Tengyan|Wang, Xiaonan|Li, Wenjing|Zhou, Ping|Kong, Lu
PMID: 27121327
Journal: Nat Med. 2016 Jun;22(6):624-31.
Title: The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death.
Author: Pozzi, Chiara|Cuomo, Alessandro|Spadoni, Ilaria|Magni, Elena|Silvola, Alessio|Conte, Alexia|Sigismund, Sara|Ravenda, Paola Simona|Bonaldi, Tiziana|Zampino, Maria Giulia|Cancelliere, Carlotta|Di Fiore, Pier Paolo|Bardelli, Alberto|Penna, Giuseppe|Rescigno,
PMID: 27135741
Journal: Am J Transl Res. 2016 Feb 15;8(2):742-8. eCollection 2016.
Title: BRD7: a novel tumor suppressor gene in different cancers.
Author: Yu, Xin|Li, Zheng|Shen, Jianxiong
PMID: 27158366
Journal: Environ Toxicol Pharmacol. 2016 Jun;44:128-33.
Title: Endoplasmic reticulum stress induces 5-fluorouracil resistance in human colon cancer cells.
Author: Kim, Joon Ki|Kang, Kyoung Ah|Piao, Mei Jing|Ryu, Yea Seong|Han, Xia|Fernando, Pattage Madushan Dilhara Jayatissa|Oh, Min Chang|Park, Jeong Eon|Shilnikova, Kristina|Boo, Sun Jin|Na, Soo-Young|Jeong, Yong Joo|Jeong, Seung Uk|Hyun, Jin Won
PMID: 27163731
Journal: Oncotarget. 2016 Jun 28;7(26):39595-39608.
Title: Efficacy of the combination of MEK and CDK4/6 inhibitors in vitro and in vivo in KRAS mutant colorectal cancer models.
Author: Lee, Michael S|Helms, Timothy L|Feng, Ningping|Gay, Jason|Chang, Qing Edward|Tian, Feng|Wu, Ji Y|Toniatti, Carlo|Heffernan, Timothy P|Powis, Garth|Kwong, Lawrence N|Kopetz, Scott
PMID: 27167191
Journal: Oncotarget. 2016 Jun 14;7(24):36842-36853.
Title: Crosstalk between CCL7 and CCR3 promotes metastasis of colon cancer cells via ERK-JNK signaling pathways.
Author: Lee, Yeo Song|Kim, So-Young|Song, Su Jeong|Hong, Hye Kyung|Lee, Yura|Oh, Bo Young|Lee, Woo Yong|Cho, Yong Beom
PMID: 27167205
Journal: J Cell Biochem. 2016 Dec;117(12):2875-2885.
Title: Resistance to 3-HTMC-Induced Apoptosis Through Activation of PI3K/Akt, MEK/ERK, and p38/COX-2/PGE2 Pathways in Human HT-29 and HCT116 Colorectal Cancer Cells.
Author: Semaan, Josiane|Pinon, Aline|Rioux, Benjamin|Hassan, Lama|Limami, Youness|Pouget, Christelle|Fagnere, Catherine|Sol, Vincent|Diab-Assaf, Mona|Simon, Alain|Liagre, Bertrand
PMID: 27192488
Journal: Carcinogenesis. 2016 Jul;37(7):731-739.
Title: Hsp70 exerts oncogenic activity in the Apc mutant Min mouse model.
Author: Tao, Yun|Messer, Jeannette S|Goss, Kathleen H|Hart, John|Bissonnette, Marc|Chang, Eugene B
PMID: 27207671
Journal: Tumour Biol. 2016 Sep;37(9):12153-12160.
Title: SH3GL1 inhibition reverses multidrug resistance in colorectal cancer cells by downregulation of MDR1/P-glycoprotein via EGFR/ERK/AP-1 pathway.
Author: Guan, Haitao|Zhao, Ping|Dai, Zhijun|Liu, Xiaoxu|Wang, Xijing
PMID: 27220321
Journal: Asian Pac J Cancer Prev. 2016;17(4):1947-59.
Title: Harmal Extract Induces Apoptosis of HCT116 Human Colon Cancer Cells, Mediated by Inhibition of Nuclear Factor-kappaB and Activator Protein-1 Signaling Pathways and Induction of Cytoprotective Genes.
Author: Elkady, Ayman I|Hussein, Rania A|El-Assouli, Sufian M
PMID: 27221880
Journal: Oncotarget. 2016 Jul 12;7(28):43907-43923.
Title: Ellagitannin-rich cloudberry inhibits hepatocyte growth factor induced cell migration and phosphatidylinositol 3-kinase/AKT activation in colon carcinoma cells and tumors in Min mice.
Author: Pajari, Anne-Maria|Paivarinta, Essi|Paavolainen, Lassi|Vaara, Elina|Koivumaki, Tuuli|Garg, Ritu|Heiman-Lindh, Anu|Mutanen, Marja|Marjomaki, Varpu|Ridley, Anne J
PMID: 27270323
Journal: Dev Reprod. 2016 Mar;20(1):1-10.
Title: Blockage of Autophagy Rescues the Dual PI3K/mTOR Inhibitor BEZ235-induced Growth Inhibition of Colorectal Cancer Cells.
Author: Oh, Iljoong|Cho, Hyunchul|Lee, Yonghoon|Cheon, Minseok|Park, Deokbae|Lee, Youngki
PMID: 27294206
Journal: Cancer Res. 2016 Aug 1;76(15):4504-15.
Title: Molecular Landscape of Acquired Resistance to Targeted Therapy Combinations in BRAF-Mutant Colorectal Cancer.
Author: Oddo, Daniele|Sennott, Erin M|Barault, Ludovic|Valtorta, Emanuele|Arena, Sabrina|Cassingena, Andrea|Filiciotto, Genny|Marzolla, Giulia|Elez, Elena|van Geel, Robin M J M|Bartolini, Alice|Crisafulli, Giovanni|Boscaro, Valentina|Godfrey, Jason T|Buscarino, M
PMID: 27312529
Journal: Cancer Lett. 2016 Sep 28;380(1):87-97.
Title: Inhibition of the NF-kappaB pathway by nafamostat mesilate suppresses colorectal cancer growth and metastasis.
Author: Lu, Yun-Xin|Ju, Huai-Qiang|Wang, Feng|Chen, Le-Zong|Wu, Qi-Nian|Sheng, Hui|Mo, Hai-Yu|Pan, Zhi-Zhong|Xie, Dan|Kang, Tie-Bang|Chen, Gong|Yun, Jing-Ping|Zeng, Zhao-Lei|Xu, Rui-Hua
PMID: 27322737
Journal: Oncotarget. 2016 Jul 19;7(29):46219-46229.
Title: Simvastatin induces heme oxygenase-1 via NF-E2-related factor 2 (Nrf2) activation through ERK and PI3K/Akt pathway in colon cancer.
Author: Jang, Hyun Joo|Hong, Eun Mi|Kim, Mikang|Kim, Jae Hyun|Jang, Juah|Park, Se Woo|Byun, Hyun Wu|Koh, Dong Hee|Choi, Min Ho|Kae, Sea Hyub|Lee, Jin
PMID: 27323826
Journal: Oncotarget. 2016 Jul 26;7(30):47699-47710.
Title: BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells.
Author: He, Kan|Chen, Dongshi|Ruan, Hang|Li, Xiangyun|Tong, Jingshan|Xu, Xiang|Zhang, Lin|Yu, Jian
PMID: 27351224
Journal: Oncotarget. 2016 Jul 26;7(30):47637-47649.
Title: CCR4 promotes metastasis via ERK/NF-kappaB/MMP13 pathway and acts downstream of TNF-alpha in colorectal cancer.
Author: Ou, Baochi|Zhao, Jingkun|Guan, Shaopei|Feng, Hao|Wangpu, Xiongzhi|Zhu, Congcong|Zong, Yaping|Ma, Junjun|Sun, Jing|Shen, Xiaohui|Zheng, Minhua|Lu, Aiguo
PMID: 27356745
Journal: Oncotarget. 2016 Aug 2;7(31):49597-49610.
Title: Reactivation of ERK and Akt confers resistance of mutant BRAF colon cancer cells to the HSP90 inhibitor AUY922.
Author: Wang, Chun Yan|Guo, Su Tang|Wang, Jia Yu|Yan, Xu Guang|Farrelly, Margaret|Zhang, Yuan Yuan|Liu, Fen|Yari, Hamed|La, Ting|Lei, Fu Xi|Jin, Lei|Zhang, Xu Dong|Jiang, Chen Chen
PMID: 27391062
Journal: Nat Biotechnol. 2016 Aug;34(8):845-51.
Title: A recellularized human colon model identifies cancer driver genes.
Author: Chen, Huanhuan Joyce|Wei, Zhubo|Sun, Jian|Bhattacharya, Asmita|Savage, David J|Serda, Rita|Mackeyev, Yuri|Curley, Steven A|Bu, Pengcheng|Wang, Lihua|Chen, Shuibing|Cohen-Gould, Leona|Huang, Emina|Shen, Xiling|Lipkin, Steven M|Copeland, Neal G|Jenkins, Nan
PMID: 27398792
Journal: Nutr Cancer. 2016 Oct;68(7):1234-46.
Title: Anticancer Activity of Buttermilk Against SW480 Colon Cancer Cells is Associated with Caspase-Independent Cell Death and Attenuation of Wnt, Akt, and ERK Signaling.
Author: Kuchta-Noctor, Anna M|Murray, Brian A|Stanton, Catherine|Devery, Rosaleen|Kelly, Phil M
PMID: 27472445
Journal: J Biol Chem. 2016 Aug 5;291(32):16923.
Title: Gossypol induces death receptor-5 through activation of ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.
Author: Sung, Bokyung|Ravindran, Jayaraj|Prasad, Sahdeo|Pandey, Manoj K|Aggarwal, Bharat B
PMID: 27496964
Journal: J Biol Chem. 2016 Aug 5;291(32):16925.
Title: Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax.
Author: Gupta, Subash C|Reuter, Simone|Phromnoi, Kanokkarn|Park, Byoungduck|Hema, Padmanabhan S|Nair, Mangalam|Aggarwal, Bharat B
PMID: 27496966
Journal: Biochim Biophys Acta. 2016 Nov;1859(11):1353-1367.
Title: Enhancer decommissioning by Snail1-induced competitive displacement of TCF7L2 and down-regulation of transcriptional activators results in EPHB2 silencing.
Author: Schnappauf, Oskar|Beyes, Sven|Dertmann, Annika|Freihen, Vivien|Frey, Patrick|Jagle, Sabine|Rose, Katja|Michoel, Tom|Grosschedl, Rudolf|Hecht, Andreas
PMID: 27504909
Journal: Tumour Biol. 2016 Oct;37(10):14205-14215.
Title: Decreased expression of LncRNA SLC25A25-AS1 promotes proliferation, chemoresistance, and EMT in colorectal cancer cells.
Author: Li, Yuan|Huang, Shengkai|Li, Yan|Zhang, Weilong|He, Kun|Zhao, Mei|Lin, Hong|Li, Dongdong|Zhang, Honggang|Zheng, Zhaoxu|Huang, Changzhi
PMID: 27553025
Journal: J Med Chem. 2016 Sep 22;59(18):8369-80.
Title: Exploring the N-Terminal Region of C-X-C Motif Chemokine 12 (CXCL12): Identification of Plasma-Stable Cyclic Peptides As Novel, Potent C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonists.
Author: Di Maro, Salvatore|Trotta, Anna Maria|Brancaccio, Diego|Di Leva, Francesco Saverio|La Pietra, Valeria|Ierano, Caterina|Napolitano, Maria|Portella, Luigi|D'Alterio, Crescenzo|Siciliano, Rosa Anna|Sementa, Deborah|Tomassi, Stefano|Carotenuto, Alfonso|Novell
PMID: 27571038
Journal: FASEB J. 2016 Dec;30(12):4159-4171.
Title: Role of neutral ceramidase in colon cancer.
Author: Garcia-Barros, Monica|Coant, Nicolas|Kawamori, Toshihiko|Wada, Masayuki|Snider, Ashley J|Truman, Jean-Philip|Wu, Bill X|Furuya, Hideki|Clarke, Christopher J|Bialkowska, Agnieszka B|Ghaleb, Amr|Yang, Vincent W|Obeid, Lina M|Hannun, Yusuf A
PMID: 27609772
Journal: World J Gastroenterol. 2016 Aug 21;22(31):7099-110.
Title: Current understanding concerning intestinal stem cells.
Author: Cui, Shuang|Chang, Peng-Yu
PMID: 27610020
Journal: Apoptosis. 2016 Nov;21(11):1291-1301.
Title: Gefitinib enhances human colon cancer cells to TRAIL-induced apoptosis of via autophagy- and JNK-mediated death receptors upregulation.
Author: Chen, Lei|Meng, Yue|Guo, Xiaoqing|Sheng, Xiaotong|Tai, Guihua|Zhang, Fenglei|Cheng, Hairong|Zhou, Yifa
PMID: 27629794
Journal: Int J Oncol. 2016 Oct;49(4):1505-1512.
Title: Downregulation of RLIP76 is associated with vincristine resistance in human colorectal cancer HCT-8/VCR cells.
Author: Wang, Wenwen|Liu, Juan|Qi, Jianni|Zhang, Junyong|Zhu, Qiang|Ma, Jincai|Qin, Chengyong
PMID: 27633085
Journal: Oncotarget. 2016 Nov 1;7(44):71400-71416.
Title: STC2 promotes the epithelial-mesenchymal transition of colorectal cancer cells through AKT-ERK signaling pathways.
Author: Chen, Bing|Zeng, Xiao|He, Yu|Wang, Xixi|Liang, Ziwei|Liu, Jingjing|Zhang, Peng|Zhu, Hongxia|Xu, Ningzhi|Liang, Shufang
PMID: 27662663
Journal: PLoS One. 2016 Sep 26;11(9):e0159927.
Title: The Association of CXC Receptor 4 Mediated Signaling Pathway with Oxaliplatin-Resistant Human Colorectal Cancer Cells.
Author: Huang, Wen-Shih|Hsieh, Meng-Chiao|Huang, Cheng-Yi|Kuo, Yi-Hung|Tung, Shui-Yi|Shen, Chien-Heng|Hsieh, Yung-Yu|Teng, Chih-Chuan|Lee, Kam-Fai|Chen, Te-Chuan|Lee, Ko-Chao|Kuo, Hsing-Chun
PMID: 27668882
Journal: BMC Cancer. 2016 Oct 12;16(1):791.
Title: Combined application of anti-VEGF and anti-EGFR attenuates the growth and angiogenesis of colorectal cancer mainly through suppressing AKT and ERK signaling in mice model.
Author: Ding, Chenbo|Li, Longmei|Yang, Taoyu|Fan, Xiaobo|Wu, Guoqiu
PMID: 27729020
Journal: Sci Signal. 2016 Oct 11;9(449):rs11.
Title: Impaired coordination between signaling pathways is revealed in human colorectal cancer using single-cell mass cytometry of archival tissue blocks.
Author: Simmons, Alan J|Scurrah, Cherie R|McKinley, Eliot T|Herring, Charles A|Irish, Jonathan M|Washington, M Kay|Coffey, Robert J|Lau, Ken S
PMID: 27729552
Journal: Exp Cell Res. 2016 Nov 15;349(1):119-127.
Title: Claudin-1 promotes TNF-alpha-induced epithelial-mesenchymal transition and migration in colorectal adenocarcinoma cells.
Author: Bhat, Ajaz A|Ahmad, Rizwan|Uppada, SrijayaPrakash B|Singh, Amar B|Dhawan, Punita
PMID: 27742576
Journal: Int J Oncol. 2016 Dec;49(6):2558-2568.
Title: Acquisition of anticancer drug resistance is partially associated with cancer stemness in human colon cancer cells.
Author: El Khoury, Flaria|Corcos, Laurent|Durand, Stephanie|Simon, Brigitte|Le Jossic-Corcos, Catherine
PMID: 27748801
Journal: Mol Cancer Ther. 2016 Dec;15(12):3015-3027.
Title: Mutant BRAF Upregulates MCL-1 to Confer Apoptosis Resistance that Is Reversed by MCL-1 Antagonism and Cobimetinib in Colorectal Cancer.
Author: Kawakami, Hisato|Huang, Shengbing|Pal, Krishnendu|Dutta, Shamit K|Mukhopadhyay, Debabrata|Sinicrope, Frank A
PMID: 27765849
Journal: Oncol Rep. 2016 Dec;36(6):3619-3626.
Title: Angiomotin promotes the malignant potential of colon cancer cells by activating the YAP-ERK/PI3K-AKT signaling pathway.
Author: Zhang, Yan|Yuan, Jun|Zhang, Xinli|Yan, Futang|Huang, Minggang|Wang, Tao|Zheng, Xiao|Zhang, Ming
PMID: 27779692
Journal: Oncotarget. 2016 Dec 6;7(49):81402-81409.
Title: Anti-EGFR antibody sensitizes colorectal cancer stem-like cells to Fluorouracil-induced apoptosis by affecting autophagy.
Author: Feng, Ye|Gao, Shuohui|Gao, Yongjian|Wang, Xuefeng|Chen, Zhi
PMID: 27833077
Journal: Oncotarget. 2016 Dec 6;7(49):81223-81240.
Title: Prognostic significance of USP33 in advanced colorectal cancer patients: new insights into beta-arrestin-dependent ERK signaling.
Author: Liu, Hongda|Zhang, Qun|Li, Kangshuai|Gong, Zheng|Liu, Zhaochen|Xu, Yunfei|Swaney, Mary Hannah|Xiao, Kunhong|Chen, Yuxin
PMID: 27835898
Journal: Cancer Chemother Pharmacol. 2016 Dec;78(6):1269-1281.
Title: Enhanced anti-tumour activity of the combination of the novel MEK inhibitor WX-554 and the novel PI3K inhibitor WX-037.
Author: Haagensen, Emma J|Thomas, Huw D|Schmalix, Wolfgang A|Payne, Andrew C|Kevorkian, Lara|Allen, Rodger A|Bevan, Paul|Maxwell, Ross J|Newell, David R
PMID: 27837257
Journal: Onco Targets Ther. 2016 Nov 30;9:7285-7295.
Title: CTGF enhances resistance to 5-FU-mediating cell apoptosis through FAK/MEK/ERK signal pathway in colorectal cancer.
Author: Yang, Kai|Gao, Kai|Hu, Gui|Wen, Yanguang|Lin, Changwei|Li, Xiaorong
PMID: 27942222
Journal: Vascul Pharmacol. 2017 Mar;90:27-35.
Title: Camptothecin promotes the production of nitric oxide that triggers subsequent S-nitrosoproteome-mediated signaling cascades in endothelial cells.
Author: Huang, Bin|Cheng, Jen-Kun|Wu, Chien-Yi|Chen, Ping-Ho|Tu, Po-Shu|Fu, Yaw-Syan|Wu, Chien-Hsing
PMID: 26239883
Journal: J Cell Biochem. 2017 Jan;118(1):191-203.
Title: Suppression of Spleen Tyrosine Kinase (Syk) by Histone Deacetylation Promotes, Whereas BAY61-3606, a Synthetic Syk Inhibitor Abrogates Colonocyte Apoptosis by ERK Activation.
Author: Dasgupta, Nirmalya|Thakur, Bhupesh Kumar|Ta, Atri|Dutta, Pujarini|Das, Santasabuj
PMID: 27293079
Journal: Oncogene. 2017 Feb 9;36(6):787-796.
Title: FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation.
Author: Tong, J|Tan, S|Zou, F|Yu, J|Zhang, L
PMID: 27399335
Journal: Arch Toxicol. 2017 Mar;91(3):1485-1495.
Title: Cytotoxic effects of the anthraquinone derivatives 1'-deoxyrhodoptilometrin and (S)-(-)-rhodoptilometrin isolated from the marine echinoderm Comanthus sp.
Author: Watjen, Wim|Ebada, Sherif S|Bergermann, Anja|Chovolou, Yvonni|Totzke, Frank|Kubbutat, Michael H G|Lin, Wenhan|Proksch, Peter
PMID: 27473261
Journal: Semin Cancer Biol. 2017 Feb;42:70-80.
Title: Smyd3-associated regulatory pathways in cancer.
Author: Giakountis, Antonis|Moulos, Panagiotis|Sarris, Michalis E|Hatzis, Pantelis|Talianidis, Iannis
PMID: 27554136
Journal: Mol Carcinog. 2017 Mar;56(3):1068-1081.
Title: KITENIN functions as a fine regulator of ErbB4 expression level in colorectal cancer via protection of ErbB4 from E3-ligase Nrdp1-mediated degradation.
Author: Sun, Eun Gene|Lee, Kyung Hwa|Ko, Yoo-Seung|Choi, Hui Jeong|Yang, Jung-In|Lee, Jae Hyuk|Chung, Ik Joo|Paek, Yun-Woong|Kim, Hangun|Bae, Jeong A|Kim, Kyung Keun
PMID: 27648936
Journal: Invest New Drugs. 2017 Feb;35(1):47-58.
Title: A phase I dose-escalation study of TAK-733, an investigational oral MEK inhibitor, in patients with advanced solid tumors.
Author: Adjei, Alex A|LoRusso, Patricia|Ribas, Antoni|Sosman, Jeffrey A|Pavlick, Anna|Dy, Grace K|Zhou, Xiaofei|Gangolli, Esha|Kneissl, Michelle|Faucette, Stephanie|Neuwirth, Rachel|Bozon, Viviana
PMID: 27650277
Journal: J Cell Sci. 2017 Jan 1;130(1):203-218.
Title: Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT-mTOR-S6K signaling and drug responses.
Author: Riedl, Angelika|Schlederer, Michaela|Pudelko, Karoline|Stadler, Mira|Walter, Stefanie|Unterleuthner, Daniela|Unger, Christine|Kramer, Nina|Hengstschlager, Markus|Kenner, Lukas|Pfeiffer, Dagmar|Krupitza, Georg|Dolznig, Helmut
PMID: 27663511
Journal: Gut. 2017 Jun;66(6):1106-1115.
Title: Inhibition of RAF1 kinase activity restores apicobasal polarity and impairs tumour growth in human colorectal cancer.
Author: Borovski, Tijana|Vellinga, Thomas T|Laoukili, Jamila|Santo, Evan E|Fatrai, Szabolcs|van Schelven, Susanne|Verheem, Andre|Marvin, Dieuwke L|Ubink, Inge|Borel Rinkes, Inne H M|Kranenburg, Onno
PMID: 27670374
Journal: Clin Cancer Res. 2017 Apr 15;23(8):2027-2037.
Title: The MAPK Pathway Regulates Intrinsic Resistance to BET Inhibitors in Colorectal Cancer.
Author: Ma, Yufang|Wang, Lihong|Neitzel, Leif R|Loganathan, Sudan N|Tang, Nan|Qin, Lili|Crispi, Emily E|Guo, Yan|Knapp, Stefan|Beauchamp, R Daniel|Lee, Ethan|Wang, Jialiang
PMID: 27678457
Journal: J Nutr Biochem. 2017 Jan;39:126-133.
Title: Western diet enhances intestinal tumorigenesis in Min/+ mice, associating with mucosal metabolic and inflammatory stress and loss of Apc heterozygosity.
Author: Niku, Mikael|Pajari, Anne-Maria|Sarantaus, Laura|Paivarinta, Essi|Storvik, Markus|Heiman-Lindh, Anu|Suokas, Santeri|Nystrom, Minna|Mutanen, Marja
PMID: 27833053
Journal: Cancer Sci. 2017 Jan;108(1):143-150.
Title: Clinicopathological significance of SPC18 in colorectal cancer: SPC18 participates in tumor progression.
Author: Hattori, Takuya|Sentani, Kazuhiro|Naohide, Oue|Sakamoto, Naoya|Yasui, Wataru
PMID: 27859949
Journal: Oncotarget. 2017 Jan 10;8(2):3441-3453.
Title: Upregulated NNT-AS1, a long noncoding RNA, contributes to proliferation and migration of colorectal cancer cells in vitro and in vivo.
Author: Wang, Qian|Yang, Lei|Hu, Xin|Jiang, Yuliang|Hu, Yizhang|Liu, Zhe|Liu, Jian|Wen, Tao|Ma, Yingmin|An, Guangyu|Feng, Guosheng
PMID: 27966450
Journal: Oncotarget. 2017 Feb 7;8(6):9251-9266.
Title: LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer.
Author: Vakana, Eliza|Pratt, Susan|Blosser, Wayne|Dowless, Michele|Simpson, Nicholas|Yuan, Xiu-Juan|Jaken, Susan|Manro, Jason|Stephens, Jennifer|Zhang, Youyan|Huber, Lysiane|Peng, Sheng-Bin|Stancato, Louis F
PMID: 27999210
Journal: Oncotarget. 2017 Jan 17;8(3):5003-5015.
Title: Concomitant inhibition of receptor tyrosine kinases and downstream AKT synergistically inhibited growth of KRAS/BRAF mutant colorectal cancer cells.
Author: Song, Qiaoling|Sun, Xiaoxiao|Guo, Hui|Yu, Qiang
PMID: 28002807
Journal: Oncotarget. 2017 Feb 7;8(6):9280-9292.
Title: Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress.
Author: Li, Xiangyun|Li, Mei|Ruan, Hang|Qiu, Wei|Xu, Xiang|Zhang, Lin|Yu, Jian
PMID: 28030835
Journal: Hum Pathol. 2017 Apr;62:56-65.
Title: Prognostic significance of stromal GREM1 expression in colorectal cancer.
Author: Jang, Bo Gun|Kim, Hye Sung|Chang, Weon Young|Bae, Jeong Mo|Oh, Hyeon Jeong|Wen, Xianyu|Jeong, Seorin|Cho, Nam Yun|Kim, Woo Ho|Kang, Gyeong Hoon
PMID: 28041973
Journal: Biomed Pharmacother. 2017 Mar;87:102-109.
Title: Taspine derivative 12k suppressed A549 cell migration through the Wnt/beta-catenin and EphrinB2 signaling pathway.
Author: Dai, Bingling|Ma, Yujiao|Yang, Tianfeng|Wang, Wenjie|Zhang, Yanmin
PMID: 28049091
Journal: Biomed Pharmacother. 2017 Mar;87:366-374.
Title: Loss of periplakin expression is associated with the tumorigenesis of colorectal carcinoma.
Author: Li, Xiang|Zhang, Guohui|Wang, Yan|Elgehama, Ahmed|Sun, Yang|Li, Lele|Gu, Yanhong|Guo, Wenjie|Xu, Qiang
PMID: 28068625
Journal: Eur J Pharmacol. 2017 Feb 15;797:1-8.
Title: SIRT2 mediated antitumor effects of shikonin on metastatic colorectal cancer.
Author: Zhang, Li-Li|Zhan, Lin|Jin, Yong-Dong|Min, Zhen-Li|Wei, Can|Wang, Qiang|Chen, Ya-Jun|Wu, Qing-Ming|Hu, Xia-Min|Yuan, Qiong
PMID: 28088387
Journal: Biochem Biophys Res Commun. 2017 Mar 18;484(4):719-725.
Title: Gab3 is required for human colorectal cancer cell proliferation.
Author: Xiang, Shihao|Wang, Na|Hui, Pingping|Ma, Jiali
PMID: 28115166
Journal: PLoS One. 2017 Jan 26;12(1):e0170595.
Title: Knockdown of NIK and IKKbeta-Binding Protein (NIBP) Reduces Colorectal Cancer Metastasis through Down-Regulation of the Canonical NF-kappaBeta Signaling Pathway and Suppression of MAPK Signaling Mediated through ERK and JNK.
Author: Qin, Mengbin|Zhang, Jinxiu|Xu, Chunyan|Peng, Peng|Tan, Lin|Liu, Shiquan|Huang, Jiean
PMID: 28125661
Journal: ACS Chem Biol. 2017 May 19;12(5):1217-1226.
Title: Biased Signaling by Agonists of Protease Activated Receptor 2.
Author: Jiang, Yuhong|Yau, Mei-Kwan|Kok, W Mei|Lim, Junxian|Wu, Kai-Chen|Liu, Ligong|Hill, Timothy A|Suen, Jacky Y|Fairlie, David P
PMID: 28169521
Journal: Pharmacol Ther. 2017 May;173:58-66.
Title: Targeting TRK family proteins in cancer.
Author: Khotskaya, Yekaterina B|Holla, Vijaykumar R|Farago, Anna F|Mills Shaw, Kenna R|Meric-Bernstam, Funda|Hong, David S
PMID: 28174090
Journal: Oncotarget. 2017 Mar 14;8(11):18106-18117.
Title: 3'-hydroxy-4'-methoxy-beta-methyl-beta-nitrostyrene inhibits tumorigenesis in colorectal cancer cells through ROS-mediated DNA damage and mitochondrial dysfunction.
Author: Tsai, Chun-Hao|Hung, Amos C|Chen, Yuan-Yin|Chiu, Ya-Wen|Hsieh, Pei-Wen|Lee, Yi-Chen|Su, Yu-Han|Chang, Po-Chih|Hu, Stephen Chu-Sung|Yuan, Shyng-Shiou F
PMID: 28178649
Journal: Oncotarget. 2017 Mar 7;8(10):16633-16641.
Title: microRNA-375 inhibits colorectal cancer cells proliferation by downregulating JAK2/STAT3 and MAP3K8/ERK signaling pathways.
Author: Wei, Ran|Yang, Qin|Han, Bing|Li, Yan|Yao, Kun|Yang, Xiuyu|Chen, Zexi|Yang, Shanshan|Zhou, Jiaqi|Li, Meizhang|Yu, Haijing|Yu, Min|Cui, Qinghua
PMID: 28186962
Journal: Mol Cell Proteomics. 2017 Apr;16(4):663-679.
Title: Time-resolved Phosphoproteome Analysis of Paradoxical RAF Activation Reveals Novel Targets of ERK.
Author: Kubiniok, Peter|Lavoie, Hugo|Therrien, Marc|Thibault, Pierre
PMID: 28188228
Journal: Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt A):1065-1074.
Title: Glucose-derived AGEs promote migration and invasion of colorectal cancer by up-regulating Sp1 expression.
Author: Deng, Ruyuan|Wu, Huo|Ran, Hui|Kong, Xiang|Hu, Lei|Wang, Xiao|Su, Qing
PMID: 28237576
Journal: PLoS One. 2017 Mar 16;12(3):e0174151.
Title: In vivo and ex vivo cetuximab sensitivity assay using three-dimensional primary culture system to stratify KRAS mutant colorectal cancer.
Author: Tashiro, Takahiro|Okuyama, Hiroaki|Endo, Hiroko|Kawada, Kenji|Ashida, Yasuko|Ohue, Masayuki|Sakai, Yoshiharu|Inoue, Masahiro
PMID: 28301591
Journal: Cancer Lett. 2017 Jun 28;396:94-102.
Title: Co-targeting of EGFR and autophagy signaling is an emerging treatment strategy in metastatic colorectal cancer.
Author: Koustas, Evangelos|Karamouzis, Michalis V|Mihailidou, Chrysovalantou|Schizas, Dimitrios|Papavassiliou, Athanasios G
PMID: 28323034
Journal: Mol Ther Nucleic Acids. 2017 Mar 17;6:140-149.
Title: miR-134: A Human Cancer Suppressor?
Author: Pan, Jing-Yu|Zhang, Feng|Sun, Cheng-Cao|Li, Shu-Jun|Li, Guang|Gong, Feng-Yun|Bo, Tao|He, Jing|Hua, Rui-Xi|Hu, Wei-Dong|Yuan, Zhan-Peng|Wang, Xin|He, Qi-Qiang|Li, De-Jia
PMID: 28325280
Journal: Int J Cancer. 2017 Jul 1;141(1):172-183.
Title: Down-regulation of DAB2IP promotes colorectal cancer invasion and metastasis by translocating hnRNPK into nucleus to enhance the transcription of MMP2.
Author: Zhu, X H|Wang, J M|Yang, S S|Wang, F F|Hu, J L|Xin, S N|Men, H|Lu, G F|Lan, X L|Zhang, D|Wang, X Y|Liao, W T|Ding, Y Q|Liang, L
PMID: 28335083
Journal: Cancer Sci. 2017 Jun;108(6):1169-1176.
Title: NUBPL, a novel metastasis-related gene, promotes colorectal carcinoma cell motility by inducing epithelial-mesenchymal transition.
Author: Wang, Yuhui|Wu, Nan|Sun, Donglin|Sun, Haiming|Tong, Dandan|Liu, Duo|Pang, Bo|Li, Su|Wei, Jia|Dai, Jialin|Liu, Yang|Bai, Jing|Geng, Jingshu|Fu, Songbin|Jin, Yan
PMID: 28346728
Journal: Mol Cancer. 2017 Mar 29;16(1):70.
Title: Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3beta/beta-catenin pathways.
Author: Zhao, Jingkun|Ou, Baochi|Han, Dingpei|Wang, Puxiongzhi|Zong, Yaping|Zhu, Congcong|Liu, Di|Zheng, Minhua|Sun, Jing|Feng, Hao|Lu, Aiguo
PMID: 28356111
Journal: Biomed Pharmacother. 2017 Jun;90:179-186.
Title: Assessment of Olea europaea L. fruit extracts: Phytochemical characterization and anticancer pathway investigation.
Author: Maalej, Amina|Bouallagui, Zouhaier|Hadrich, Fatma|Isoda, Hiroko|Sayadi, Sami
PMID: 28360012
Journal: Org Biomol Chem. 2017 Apr 18;15(16):3455-3465.
Title: Rational design, synthesis, and biological evaluation of Pan-Raf inhibitors to overcome resistance.
Author: Wang, Lu|Zhu, Gaoyuan|Zhang, Qing|Duan, Chunqi|Zhang, Yanmin|Zhang, Zhimin|Zhou, Yujun|Lu, Tao|Tang, Weifang
PMID: 28368067
Journal: Oncogene. 2017 Jul 27;36(30):4336-4348.
Title: TGFbeta engages MEK/ERK to differentially regulate benign and malignant pancreas cell function.
Author: Principe, D R|Diaz, A M|Torres, C|Mangan, R J|DeCant, B|McKinney, R|Tsao, M-S|Lowy, A|Munshi, H G|Jung, B|Grippo, P J
PMID: 28368414
Journal: Biochem Biophys Res Commun. 2017 May 13;486(4):1062-1068.
Title: Phosphorylation of ETV4 at Ser73 by ERK kinase could block ETV4 ubiquitination degradation in colorectal cancer.
Author: Xiao, Jie|Yang, Shu|Shen, Ping|Wang, Yaxi|Sun, Haimei|Ji, Fengqing|Zhou, Deshan
PMID: 28373072
Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2017 Mar 20;37(3):367-372.
Title: [Inhibitory effect of apatinib on HCT-116 cells and its mechanism].
Author: Yin, Liang|Wang, Jin|Huang, Feng-Chang|Zhang, Yun-Fei|Xu, Ning|Wen, Zheng-Qi|Li, Wen-Liang|Dong, Jian
PMID: 28377354
Journal: J Mol Endocrinol. 2017 Jul;59(1):13-27.
Title: RSK activation via ERK modulates human colon cancer cells response to PTHrP.
Author: Calvo, Natalia|Carriere, Pedro|Martin, Maria Julia|Gentili, Claudia
PMID: 28385776
Journal: FEBS Lett. 2017 May;591(10):1371-1382.
Title: Resistin causes G1 arrest in colon cancer cells through upregulation of SOCS3.
Author: Singh, Snahlata|Chouhan, Surbhi|Mohammad, Naoshad|Bhat, Manoj Kumar
PMID: 28417458
Journal: Cell Signal. 2017 Aug;36:67-78.
Title: Identification of NCK1 as a novel downstream effector of STAT3 in colorectal cancer metastasis and angiogenesis.
Author: Zhang, Fan|Lu, Yan-Xia|Chen, Qing|Zou, Hui-Mei|Zhang, Jian-Ming|Hu, Yu-Han|Li, Xiao-Min|Zhang, Wen-Juan|Zhang, Wei|Lin, Chun|Li, Xue-Nong
PMID: 28455144
Journal: Cell Cycle. 2017 Jun 18;16(12):1193-1200.
Title: The CDK4/6 inhibitor palbociclib synergizes with irinotecan to promote colorectal cancer cell death under hypoxia.
Author: Zhang, Jun|Zhou, Lanlan|Zhao, Shuai|Dicker, David T|El-Deiry, Wafik S
PMID: 28486050
Journal: Cell Death Dis. 2017 May 25;8(5):e2815.
Title: Furanodienone induces G0/G1 arrest and causes apoptosis via the ROS/MAPKs-mediated caspase-dependent pathway in human colorectal cancer cells: a study in vitro and in vivo.
Author: Jiang, Ying|Wang, Xiaoqin|Hu, Daode
PMID: 28542135
Journal: Br J Nutr. 2017 May;117(9):1212-1221.
Title: Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line.
Author: McCann, Mark J|Rotjanapun, Kunjana|Hesketh, John E|Roy, Nicole C
PMID: 28571588
Journal: Cell J. 2017 Spring;19(Suppl 1):106-112.
Title: Continuous or Transient High Level of Glucose Exposure Differentially Increases Coronary Artery Endothelial Cell Proliferation and Human Colon Cancer Cell Proliferation.
Author: Shimoda, Yoko|Tagaya, Yuko|Saito, Tsugumichi|Yamada, Eijiro|Osaki, Aya|Nakajima, Yasuyo|Ozawa, Atsushi|Satoh, Tetsurou|Okada, Junichi|Okada, Shuichi|Yamada, Masanobu
PMID: 28580314
Journal: BMC Gastroenterol. 2017 Jun 7;17(1):73.
Title: Anti-fibrogenic effect of PPAR-gamma agonists in human intestinal myofibroblasts.
Author: Koo, Jun Bon|Nam, Myeong-Ok|Jung, Younshin|Yoo, Jongman|Kim, Duk Hwan|Kim, Gwangil|Shin, Sung Jae|Lee, Kee Myung|Hahm, Ki Baik|Kim, Jong Woo|Hong, Sung Pyo|Lee, Kwang Jae|Yoo, Jun Hwan
PMID: 28592228
Journal: Cancer Lett. 2017 Aug 28;402:153-165.
Title: RSPO2 suppresses colorectal cancer metastasis by counteracting the Wnt5a/Fzd7-driven noncanonical Wnt pathway.
Author: Dong, Xiaoming|Liao, Wanqin|Zhang, Li|Tu, Xi|Hu, Jin|Chen, Tianke|Dai, Xiaowei|Xiong, Yan|Liang, Weicheng|Ding, Chaodong|Liu, Rui|Dai, Juji|Wang, Ouchen|Lu, Liting|Lu, Xincheng
PMID: 28600110
Journal: Cancer Res. 2017 Aug 1;77(15):4026-4038.
Title: Autocrine BMP-4 Signaling Is a Therapeutic Target in Colorectal Cancer.
Author: Yokoyama, Yuichiro|Watanabe, Toshiaki|Tamura, Yusuke|Hashizume, Yoshinobu|Miyazono, Kohei|Ehata, Shogo
PMID: 28611046
Journal: Sci Rep. 2017 Jun 20;7(1):3888.
Title: The traditional Chinese medicine Achyranthes bidentata and our de novo conception of its metastatic chemoprevention: from phytochemistry to pharmacology.
Author: Jiang, Zhou|Qian, Jun|Dong, Haiyan|Yang, Jingyi|Yu, Xiaobo|Chen, Jianzhong|Chen, Hongning|Shi, Qing|Jia, Lee
PMID: 28634392
Journal: PLoS One. 2017 Jun 22;12(6):e0179510.
Title: Bilateral blockade of MEK- and PI3K-mediated pathways downstream of mutant KRAS as a treatment approach for peritoneal mucinous malignancies.
Author: Kuracha, Murali R|Thomas, Peter|Loggie, Brian W|Govindarajan, Venkatesh
PMID: 28640835
Journal: NPJ Syst Biol Appl. 2017 Jun 2;3:14.
Title: Clinical responses to ERK inhibition in BRAF(V600E)-mutant colorectal cancer predicted using a computational model.
Author: Kirouac, Daniel C|Schaefer, Gabriele|Chan, Jocelyn|Merchant, Mark|Orr, Christine|Huang, Shih-Min A|Moffat, John|Liu, Lichuan|Gadkar, Kapil|Ramanujan, Saroja
PMID: 28649441
Journal: Mol Cancer Res. 2017 Oct;15(10):1431-1444.
Title: BRAF-inhibitor Associated MEK Mutations Increase RAF-Dependent and -Independent Enzymatic Activity.
Author: Emery, Caroline M|Monaco, Kelli-Ann|Wang, Ping|Balak, Marissa|Freeman, Alyson|Meltzer, Jodi|Delach, Scott M|Rakiec, Daniel|Ruddy, David A|Korn, Joshua M|Haling, Jacob|Acker, Michael G|Caponigro, Giordano
PMID: 28655712
Journal: Mol Med Rep. 2017 Aug;16(2):2211-2216.
Title: Effect of nonylphenol on the regulation of cell growth in colorectal cancer cells.
Author: Yang, Xuefeng|Huang, Handong|Wang, Maijian|Zheng, Xingbin|Xu, Jie|Xie, Ming
PMID: 28656208
Journal: Int J Oncol. 2017 Sep;51(3):801-811.
Title: Zinc-finger protein 545 is inactivated due to promoter methylation and functions as a tumor suppressor through the Wnt/beta-catenin, PI3K/AKT and MAPK/ERK signaling pathways in colorectal cancer.
Author: Xiang, Shili|Xiang, Tingxiu|Xiao, Qian|Li, Yunhai|Shao, Bianfei|Luo, Tao
PMID: 28677721
Journal: Cell Rep. 2017 Jul 25;20(4):999-1015.
Title: A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution.
Author: Anderson, Grace R|Winter, Peter S|Lin, Kevin H|Nussbaum, Daniel P|Cakir, Merve|Stein, Elizabeth M|Soderquist, Ryan S|Crawford, Lorin|Leeds, Jim C|Newcomb, Rachel|Stepp, Priya|Yip, Catherine|Wardell, Suzanne E|Tingley, Jennifer P|Ali, Moiez|Xu, Mengmeng|Ry
PMID: 28746882
Journal: Lab Invest. 2017 Nov;97(11):1343-1353.
Title: Berberine inhibits colitis-associated tumorigenesis via suppressing inflammatory responses and the consequent EGFR signaling-involved tumor cell growth.
Author: Li, Dandan|Zhang, Youyu|Liu, Kun|Zhao, Yujie|Xu, Beibei|Xu, Liang|Tan, Li|Tian, Yuan|Li, Cunxi|Zhang, Wenqing|Cao, Hanwei|Zhan, Yan-Yan|Hu, Tianhui
PMID: 28759012
Journal: Oncogene. 2017 Nov 16;36(46):6480-6489.
Title: Tumor microenvironment confers mTOR inhibitor resistance in invasive intestinal adenocarcinoma.
Author: Fujishita, T|Kojima, Y|Kajino-Sakamoto, R|Taketo, M M|Aoki, M
PMID: 28759045
Journal: PLoS One. 2017 Aug 2;12(8):e0180541.
Title: Cancer stem cell-related gene expression as a potential biomarker of response for first-in-class imipridone ONC201 in solid tumors.
Author: Prabhu, Varun V|Lulla, Amriti R|Madhukar, Neel S|Ralff, Marie D|Zhao, Dan|Kline, Christina Leah B|Van den Heuvel, A Pieter J|Lev, Avital|Garnett, Mathew J|McDermott, Ultan|Benes, Cyril H|Batchelor, Tracy T|Chi, Andrew S|Elemento, Olivier|Allen, Joshua E|E
PMID: 28767654
Journal: J Pathol Clin Res. 2017 Jul 14;3(3):155-170.
Title: Endothelial protein C receptor is overexpressed in colorectal cancer as a result of amplification and hypomethylation of chromosome 20q.
Author: Lal, Neeraj|Willcox, Carrie R|Beggs, Andrew|Taniere, Philippe|Shikotra, Aarti|Bradding, Peter|Adams, Richard|Fisher, David|Middleton, Gary|Tselepis, Chris|Willcox, Benjamin E
PMID: 28770100
Journal: Oncol Lett. 2017 Aug;14(2):2125-2130.
Title: Proliferation and invasion of ovarian cancer cells are suppressed by knockdown of TRIM11.
Author: Chen, Yan|Sun, Jin|Ma, Junyan
PMID: 28781653
Journal: Chem Biol Interact. 2017 Sep 25;275:162-170.
Title: Antitumor activity of beta-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways.
Author: Daaboul, Hamid E|Daher, Costantine F|Bodman-Smith, Kikki|Taleb, Robin I|Shebaby, Wassim N|Boulos, Joelle|Dagher, Carole|Mroueh, Mohamad A|El-Sibai, Mirvat
PMID: 28782499
Journal: PLoS One. 2017 Aug 10;12(8):e0182588.
Title: HspB5 correlates with poor prognosis in colorectal cancer and prompts epithelial-mesenchymal transition through ERK signaling.
Author: Li, Qinghua|Wang, Yanlan|Lai, Yuexing|Xu, Ping|Yang, Zhiwen
PMID: 28796798
Journal: Sci Rep. 2017 Aug 15;7(1):8265.
Title: An epithelial-to-mesenchymal transition-inducing potential of granulocyte macrophage colony-stimulating factor in colon cancer.
Author: Chen, Yaqiong|Zhao, Zhi|Chen, Yu|Lv, Zhonglin|Ding, Xin|Wang, Renxi|Xiao, He|Hou, Chunmei|Shen, Beifen|Feng, Jiannan|Guo, Renfeng|Li, Yan|Peng, Hui|Han, Gencheng|Chen, Guojiang
PMID: 28811578
Journal: J Biol Chem. 2017 Sep 29;292(39):16321-16332.
Title: Syndecan-2 cytoplasmic domain up-regulates matrix metalloproteinase-7 expression via the protein kinase Cgamma-mediated FAK/ERK signaling pathway in colon cancer.
Author: Jang, Bohee|Jung, Hyejung|Choi, Sojoong|Lee, Young Hun|Lee, Seung-Taek|Oh, Eok-Soo
PMID: 28821612
Journal: J Biol Chem. 2017 Oct 13;292(41):17046-17056.
Title: Hypoxia-inducible factor 2alpha (HIF-2alpha) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity.
Author: Ma, Xiaoya|Zhang, Huabing|Xue, Xiang|Shah, Yatrik M
PMID: 28848049
Journal: J Antibiot (Tokyo). 2017 Sep 6. pii: ja2017100.
Title: A guanine derivative as a new MEK inhibitor produced by Streptomyces sp. MK63-43F2.
Author: Iijima, Masatomi|Kubota, Yuji|Sawa, Ryuichi|Kubota, Yumiko|Hatano, Masaki|Igarashi, Masayuki|Kawada, Manabu|Momose, Isao|Takekawa, Mutsuhiro|Shibasaki, Masakatsu
PMID: 28874847
Journal: NPJ Syst Biol Appl. 2017 Sep 4;3:25.
Title: Erratum: Clinical responses to ERK inhibition in BRAF(V600E)-mutant colorectal cancer predicted using a computational model.
Author: Kirouac, Daniel C|Schaefer, Gabriele|Chan, Jocelyn|Merchant, Mark|Orr, Christine|Huang, Shih-Min A|Moffat, John|Liu, Lichuan|Gadkar, Kapil|Ramanujan, Saroja
PMID: 28879057
Journal: Oncotarget. 2017 May 15;8(34):56659-56671.
Title: PRPF overexpression induces drug resistance through actin cytoskeleton rearrangement and epithelial-mesenchymal transition.
Author: Islam, Salman Ul|Shehzad, Adeeb|Sonn, Jong Kyung|Lee, Young Sup
PMID: 28915620
Journal: Cell Death Discov. 2017 Sep 18;3:17063.
Title: The lauric acid-activated signaling prompts apoptosis in cancer cells.
Author: Lappano, Rosamaria|Sebastiani, Anna|Cirillo, Francesca|Rigiracciolo, Damiano Cosimo|Galli, Giulia Raffaella|Curcio, Rosita|Malaguarnera, Roberta|Belfiore, Antonino|Cappello, Anna Rita|Maggiolini, Marcello
PMID: 28924490
Journal: Mol Biol Cell. 2017 Nov 15;28(24):3532-3541.
Title: Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2.
Author: Okumura, Fumihiko|Joo-Okumura, Akiko|Obara, Keisuke|Petersen, Alexander|Nishikimi, Akihiko|Fukui, Yoshinori|Nakatsukasa, Kunio|Kamura, Takumi
PMID: 28931592
Journal: Oncotarget. 2017 Apr 20;8(35):58587-58600.
Title: Targeting progastrin enhances radiosensitization of colorectal cancer cells.
Author: Kowalski-Chauvel, Aline|Gouaze-Andersson, Valerie|Vignolle-Vidoni, Alix|Delmas, Caroline|Toulas, Christine|Cohen-Jonathan-Moyal, Elizabeth|Seva, Catherine
PMID: 28938581
Journal: Mol Med Rep. 2017 Nov;16(5):7796-7804.
Title: Sulforaphane induces p53deficient SW480 cell apoptosis via the ROSMAPK signaling pathway.
Author: Lan, Hai|Yuan, Hongyin|Lin, Congyao
PMID: 28944886
Journal: Cancer Res. 2017 Dec 1;77(23):6513-6523.
Title: Mechanisms of Acquired Resistance to BRAF V600E Inhibition in Colon Cancers Converge on RAF Dimerization and Are Sensitive to Its Inhibition.
Author: Yaeger, Rona|Yao, Zhan|Hyman, David M|Hechtman, Jaclyn F|Vakiani, Efsevia|Zhao, HuiYong|Su, Wenjing|Wang, Lu|Joelson, Andrew|Cercek, Andrea|Baselga, Jose|de Stanchina, Elisa|Saltz, Leonard|Berger, Michael F|Solit, David B|Rosen, Neal
PMID: 28951457
Journal: Cancer Lett. 2017 Dec 28;411:90-99.
Title: SUMOylation of IQGAP1 promotes the development of colorectal cancer.
Author: Liang, Ziwei|Yang, Yanfang|He, Yu|Yang, Pengbo|Wang, Xixi|He, Gu|Zhang, Peng|Zhu, Hongxia|Xu, Ningzhi|Zhao, Xia|Liang, Shufang
PMID: 28987385
Journal: Oncol Rep. 2017 Dec;38(6):3685-3692.
Title: Downregulation of ZNF278 arrests the cell cycle and decreases the proliferation of colorectal cancer cells via inhibition of the ERK/MAPK pathway.
Author: Tian, Xiao-Qing|Guo, Fang-Fang|Sun, Dan-Feng|Wang, Ying-Chao|Yang, Li|Chen, Sheng-Liang|Hong, Jie|Fang, Jing-Yuan
PMID: 29039562
Journal: Oncol Rep. 2017 Nov;38(5):3187-3196.
Title: MicroRNA337 inhibits colorectal cancer progression by directly targeting KRAS and suppressing the AKT and ERK pathways.
Author: Liu, Xuerong|Wang, Yan|Zhao, Jinglong
PMID: 29048669
Journal: Oncotarget. 2017 Aug 7;8(42):72633-72651.
Title: RPN2 promotes colorectal cancer cell proliferation through modulating the glycosylation status of EGFR.
Author: Li, Haiping|Al-Japairai, K|Tao, Yong|Xiang, Zheng
PMID: 29069815
Journal: Cancer Cell Int. 2017 Oct 28;17:91.
Title: miR-422a inhibits cell proliferation in colorectal cancer by targeting AKT1 and MAPK1.
Author: Wei, Wen-Ting|Nian, Xin-Xin|Wang, Shu-Yang|Jiao, Hong-Li|Wang, Yong-Xia|Xiao, Zhi-Yuan|Yang, Run-Wei|Ding, Yan-Qing|Ye, Ya-Ping|Liao, Wen-Ting
PMID: 29118671
Journal: J Pharmacol Sci. 2017 Dec;135(4):148-155.
Title: Butyrate suppresses motility of colorectal cancer cells via deactivating Akt/ERK signaling in histone deacetylase dependent manner.
Author: Li, Qingran|Ding, Chujie|Meng, Tuo|Lu, Wenjie|Liu, Wenyue|Hao, Haiping|Cao, Lijuan
PMID: 29233468
Journal: Front Cell Neurosci. 2017 Dec 13;11:387.
Title: Netrin-1 Prevents Rat Primary Cortical Neurons from Apoptosis via the DCC/ERK Pathway.
Author: Chen, Jianhao|Du, Houwei|Zhang, Yixian|Chen, Hongbin|Zheng, Mouwei|Lin, Peiqiang|Lan, Quan|Yuan, Qilin|Lai, Yongxing|Pan, Xiaodong|Chen, Ronghua|Liu, Nan
PMID: 29321724
Journal: Oncotarget. 2017 Dec 5;8(67):111943-111965.
Title: Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells.
Author: Diaz-Valdivia, Natalia I|Calderon, Claudia C|Diaz, Jorge E|Lobos-Gonzalez, Lorena|Sepulveda, Hugo|Ortiz, Rina J|Martinez, Samuel|Silva, Veronica|Maldonado, Horacio J|Silva, Patricio|Wehinger, Sergio|Burzio, Veronica A|Torres, Vicente A|Montecino, Martin|L
PMID: 29340103
Journal: Oncol Lett. 2017 Dec;14(6):7923-7930.
Title: Chloroform extract of Hedyotis diffusa Willd inhibits viability of human colorectal cancer cells via suppression of AKT and ERK signaling pathways.
Author: Yan, Zhaokun|Feng, Jianyu|Peng, Jun|Lai, Zijun|Zhang, Ling|Jin, Yiyi|Yang, Hong|Chen, Wujin|Lin, Jiumao
PMID: 29344237
Journal: J Cell Biochem. 2018 Mar;119(3):2460-2469.
Title: Therapeutic Potential of Targeting PI3K/AKT Pathway in Treatment of Colorectal Cancer: Rational and Progress.
Author: Bahrami, Afsane|Khazaei, Majid|Hasanzadeh, Malihe|ShahidSales, Soodabeh|Joudi Mashhad, Mona|Farazestanian, Marjaneh|Sadeghnia, Hamid Reza|Rezayi, Majid|Maftouh, Mina|Hassanian, Seyed Mahdi|Avan, Amir
PMID: 28230287
Journal: J Cell Physiol. 2018 Mar;233(3):2058-2066.
Title: Targeting RAS signaling pathway as a potential therapeutic target in the treatment of colorectal cancer.
Author: Bahrami, Afsane|Hassanian, Seyed Mahdi|ShahidSales, Soodabeh|Farjami, Zahra|Hasanzadeh, Malihe|Anvari, Kazem|Aledavood, Amir|Maftouh, Mina|Ferns, Gordon A|Khazaei, Majid|Avan, Amir
PMID: 28262927
Journal: J Cell Physiol. 2018 Mar;233(3):2162-2169.
Title: The therapeutic potential of targeting the BRAF mutation in patients with colorectal cancer.
Author: Bahrami, Afsane|Hesari, AmirReza|Khazaei, Majid|Hassanian, Seyed Mahdi|Ferns, Gordon A|Avan, Amir
PMID: 28407239
Journal: Oncol Res. 2018 Mar 5;26(2):209-217.
Title: Procaine Inhibits the Proliferation and Migration of Colon Cancer Cells Through Inactivation of the ERK/MAPK/FAK Pathways by Regulation of RhoA.
Author: Li, Chang|Gao, Shuohui|Li, Xiaoping|Li, Chang|Ma, Lianjun
PMID: 28492141
Journal: Tumori. 2018 Jan-Feb;104(1):43-50.
Title: Long noncoding RNA CCAT1 promotes cell proliferation and metastasis in human medulloblastoma via MAPK pathway.
Author: Gao, Ran|Zhang, Rui|Zhang, Cuicui|Zhao, Li|Zhang, Yue
PMID: 28777430
Journal: J Cell Commun Signal. 2018 Jun;12(2):451-466.
Title: miR-217-5p induces apoptosis by directly targeting PRKCI, BAG3, ITGAV and MAPK1 in colorectal cancer cells.
Author: Flum, Marion|Kleemann, Michael|Schneider, Helga|Weis, Benjamin|Fischer, Simon|Handrick, Rene|Otte, Kerstin
PMID: 28905214
Journal: Clin Cancer Res. 2018 Jan 15;24(2):433-444.
Title: Monoclonal Antibodies Directed against Cadherin RGD Exhibit Therapeutic Activity against Melanoma and Colorectal Cancer Metastasis.
Author: Bartolome, Ruben A|Aizpurua, Carmen|Jaen, Marta|Torres, Sofia|Calvino, Eva|Imbaud, Juan I|Casal, J Ignacio
PMID: 28916526
Journal: Am J Physiol Gastrointest Liver Physiol. 2018 Jan 1;314(1):G22-G31.
Title: Macrophage depletion using clodronate liposomes decreases tumorigenesis and alters gut microbiota in the AOM/DSS mouse model of colon cancer.
Author: Bader, Jackie E|Enos, Reilly T|Velazquez, Kandy T|Carson, Meredith S|Nagarkatti, Mitzi|Nagarkatti, Prakash S|Chatzistamou, Ioulia|Davis, J Mark|Carson, James A|Robinson, Cory M|Murphy, E Angela
PMID: 29025731
Journal: Mol Oncol. 2018 Mar;12(3):287-304.
Title: Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor.
Author: Whittaker, Steven R|Barlow, Clare|Martin, Mathew P|Mancusi, Caterina|Wagner, Steve|Self, Annette|Barrie, Elaine|Te Poele, Robert|Sharp, Swee|Brown, Nathan|Wilson, Stuart|Jackson, Wayne|Fischer, Peter M|Clarke, Paul A|Walton, Michael I|McDonald, Edward|Bla
PMID: 29063678
Journal: Anticancer Agents Med Chem. 2018;18(4):583-590.
Title: Oleanolic Acid Inhibits Colorectal Cancer Angiogenesis by Blocking the VEGFR2 Signaling Pathway.
Author: Niu, Guoping|Sun, Li|Pei, Yunfeng|Wang, Duping
PMID: 29065844
Journal: J Cell Biochem. 2018 Mar;119(3):2864-2874.
Title: HOXA3 promotes tumor growth of human colon cancer through activating EGFR/Ras/Raf/MEK/ERK signaling pathway.
Author: Zhang, Xianxiang|Liu, Guangwei|Ding, Lei|Jiang, Tao|Shao, Shihong|Gao, Yuan|Lu, Yun
PMID: 29073728
Journal: Cancer Sci. 2018 Jan;109(1):84-93.
Title: Rac GTPase activating protein 1 promotes oncogenic progression of epithelial ovarian cancer.
Author: Wang, Chuanjiang|Wang, Wenxia|Liu, Yujuan|Yong, Min|Yang, Yamei|Zhou, Honggui
PMID: 29095547
Journal: Mol Med Rep. 2018 Jan;17(1):542-548.
Title: GOLPH3 expression promotes the resistance of HT29 cells to 5fluorouracil by activating multiple signaling pathways.
Author: Wang, Ming-Zhen|Qiu, Cheng-Zhi|Yu, Wai-Shi|Guo, Yan-Ta|Wang, Chun-Xiao|Chen, Zhi-Xiong
PMID: 29115442
Journal: Int Immunopharmacol. 2018 Jan;54:296-302.
Title: TNFalpha induces tolerant production of CXC chemokines in colorectal cancer HCT116 cells via A20 inhibition of ERK signaling.
Author: Zhou, Xin|An, Dongjian|Liu, Xueting|Jiang, Manli|Yuan, Chuang|Hu, Jinyue
PMID: 29175508
Journal: Mol Oncol. 2018 Feb;12(2):224-238.
Title: MAPK inhibitors induce serine peptidase inhibitor Kazal type 1 (SPINK1) secretion in BRAF V600E-mutant colorectal adenocarcinoma.
Author: Rasanen, Kati|Dang, Kien X|Mustonen, Harri|Ho, Tho H|Lintula, Susanna|Koistinen, Hannu|Stenman, Ulf-Hakan|Haglund, Caj|Stenman, Jakob
PMID: 29193645
Journal: Mol Med Rep. 2018 Feb;17(2):2593-2599.
Title: Fibroblast activation protein-alpha in tumor cells promotes colorectal cancer angiogenesis via the Akt and ERK signaling pathways.
Author: Cao, Feng|Wang, Songsong|Wang, Huanqin|Tang, Wei
PMID: 29207091
Journal: Mol Cancer Res. 2018 Mar;16(3):378-389.
Title: Targeting CDK1 and MEK/ERK Overcomes Apoptotic Resistance in BRAF-Mutant Human Colorectal Cancer.
Author: Zhang, Peng|Kawakami, Hisato|Liu, Weizhen|Zeng, Xiangyu|Strebhardt, Klaus|Tao, Kaixiong|Huang, Shengbing|Sinicrope, Frank A
PMID: 29233910
Journal: Mol Cell Proteomics. 2018 Apr;17(4):550-564.
Title: Specificity of Phosphorylation Responses to Mitogen Activated Protein (MAP) Kinase Pathway Inhibitors in Melanoma Cells.
Author: Basken, Joel|Stuart, Scott A|Kavran, Andrew J|Lee, Thomas|Ebmeier, Christopher C|Old, William M|Ahn, Natalie G
PMID: 29255136
Journal: Cancer Cell Int. 2018 Jan 4;18:4.
Title: Effect of long non-coding RNA Gas5 on proliferation, migration, invasion and apoptosis of colorectal cancer HT-29 cell line.
Author: Li, Jin|Wang, Yuan|Zhang, Cheng-Gong|Xiao, Hai-Juan|Hou, Jun-Ming|He, Jing-Dong
PMID: 29308053
Journal: Mol Cancer Res. 2018 Mar;16(3):403-416.
Title: Differential Regulation of LET-7 by LIN28B Isoform-Specific Functions.
Author: Mizuno, Rei|Chatterji, Priya|Andres, Sarah|Hamilton, Kathryn|Simon, Lauren|Foley, Shawn W|Jeganathan, Arjun|Gregory, Brian D|Madison, Blair|Rustgi, Anil K
PMID: 29330293
Journal: Med Sci Monit. 2018 Jan 17;24:332-341.
Title: Caveolin-1 Inhibits Proliferation, Migration, and Invasion of Human Colorectal Cancer Cells by Suppressing Phosphorylation of Epidermal Growth Factor Receptor.
Author: Yang, Juanli|Zhu, Tienian|Zhao, Ruijing|Gao, Dongmei|Cui, Yujie|Wang, Kun|Guo, Yanli
PMID: 29339715
Journal: Mol Med Rep. 2018 Mar;17(3):4203-4212.
Title: Tunicamycin inhibits colon carcinoma growth and aggressiveness via modulation of the ERK-JNK-mediated AKT/mTOR signaling pathway.
Author: You, Shuping|Li, Weihong|Guan, Yun
PMID: 29344654
Journal: Curr Mol Pharmacol. 2018;11(3):184-190.
Title: Targeting M3 Muscarinic Receptors for Colon Cancer Therapy.
Author: Felton, Jessica|Hu, Shien|Raufman, Jean-Pierre
PMID: 29357811
Journal: Eur Rev Med Pharmacol Sci. 2018 Jan;22(1):95-100.
Title: Formyl peptide receptor 2 mediated chemotherapeutics drug resistance in colon cancer cells.
Author: Su, L-D|Peng, J-M|Ge, Y-B
PMID: 29364475
Journal: Sci Rep. 2018 Jan 29;8(1):1767.
Title: DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis.
Author: Togel, Lars|Nightingale, Rebecca|Wu, Rui|Chueh, Anderly C|Al-Obaidi, Sheren|Luk, Ian|Davalos-Salas, Mercedes|Chionh, Fiona|Murone, Carmel|Buchanan, Daniel D|Chatterton, Zac|Sieber, Oliver M|Arango, Diego|Tebbutt, Niall C|Williams, David|Dhillon, Amardeep
PMID: 29379130
Journal: Genes Chromosomes Cancer. 2018 Jun;57(6):304-310.
Title: XPNPEP3 is a novel transcriptional target of canonical Wnt/beta-catenin signaling.
Author: Kumar, Raju|Kotapalli, Viswakalyan|Naz, Ashmala|Gowrishankar, Swarnalata|Rao, Satish|Pollack, Jonathan R|Bashyam, Murali Dharan
PMID: 29383790
Journal: Sci Rep. 2018 Feb 5;8(1):2334.
Title: p38 activation induces production of miR-146a and miR-31 to repress E-selectin expression and inhibit transendothelial migration of colon cancer cells.
Author: Zhong, Liang|Huot, Jacques|Simard, Martin J
PMID: 29402939
Journal: Cancer Discov. 2018 Apr;8(4):417-427.
Title: Convergent Therapeutic Strategies to Overcome the Heterogeneity of Acquired Resistance in BRAF(V600E) Colorectal Cancer.
Author: Hazar-Rethinam, Mehlika|Kleyman, Marianna|Han, G Celine|Liu, David|Ahronian, Leanne G|Shahzade, Heather A|Chen, Lifeng|Parikh, Aparna R|Allen, Jill N|Clark, Jeffrey W|Kwak, Eunice L|Faris, Jason E|Murphy, Janet E|Hong, Theodore S|Van Seventer, Emily E|Nad
PMID: 29431697
Journal: Cell Death Dis. 2018 Feb 13;9(2):217.
Title: Baicalin induces cellular senescence in human colon cancer cells via upregulation of DEPP and the activation of Ras/Raf/MEK/ERK signaling.
Author: Wang, Zhou|Ma, Lingman|Su, Mengqi|Zhou, Yiran|Mao, Ke|Li, Chengqin|Peng, Guangyong|Zhou, Changlin|Shen, Baiyong|Dou, Jie
PMID: 29440765
Journal: Adv Biol Regul. 2018 May;68:46-54.
Title: Interaction of the Wnt/beta-catenin and RAS-ERK pathways involving co-stabilization of both beta-catenin and RAS plays important roles in the colorectal tumorigenesis.
Author: Lee, Sang-Kyu|Hwang, Jeong-Ha|Choi, Kang-Yell
PMID: 29449169
Journal: Oncol Lett. 2018 Mar;15(3):3971-3976.
Title: TGFBR1*6A is a potential modifier of migration and invasion in colorectal cancer cells.
Author: Zhou, Rui|Huang, Ying|Cheng, Boran|Wang, Yulei|Xiong, Bin
PMID: 29467907
Journal: Int Immunopharmacol. 2018 Apr;57:82-90.
Title: Andrographolide derivative CX-10 ameliorates dextran sulphate sodium-induced ulcerative colitis in mice: Involvement of NF-kappaB and MAPK signalling pathways.
Author: Gao, Zhenfang|Yu, Cuicui|Liang, Haiyue|Wang, Xuekai|Liu, Yue|Li, Xin|Ji, Kai|Xu, Hui|Yang, Mingyan|Liu, Ke|Qi, Dong|Fan, Huaying
PMID: 29475099
Journal: Cancer Sci. 2018 May;109(5):1455-1467.
Title: Impairment of K-Ras signaling networks and increased efficacy of epidermal growth factor receptor inhibitors by a novel synthetic miR-143.
Author: Akao, Yukihiro|Kumazaki, Minami|Shinohara, Haruka|Sugito, Nobuhiko|Kuranaga, Yuki|Tsujino, Takuya|Yoshikawa, Yuki|Kitade, Yukio
PMID: 29498789
Journal: Cancer Biomark. 2018;21(4):883-891.
Title: Expressions of IGF-1, ERK, GLUT4, IRS-1 in metabolic syndrome complicated with colorectal cancer and their associations with the clinical characteristics of CRC.
Author: Hu, Jianxia|Liu, Xiaoyi|Chi, Jingwei|Che, Kui|Feng, Yan|Zhao, Shihua|Wang, Zhongchao|Wang, Yangang
PMID: 29504525
Journal: Oncogene. 2018 Jun;37(24):3183-3199.
Title: Classifying BRAF alterations in cancer: new rational therapeutic strategies for actionable mutations.
Author: Dankner, Matthew|Rose, April A N|Rajkumar, Shivshankari|Siegel, Peter M|Watson, Ian R
PMID: 29540830
Journal: Clin Exp Pharmacol Physiol. 2018 Jul;45(7):729-741.
Title: Inhibition of microRNA-21-3p suppresses proliferation as well as invasion and induces apoptosis by targeting RNA-binding protein with multiple splicing through Smad4/extra cellular signal-regulated protein kinase signalling pathway in human colorectal can
Author: Hou, Nengyi|Guo, Zhiyi|Zhao, Gaoping|Jia, Guiqing|Luo, Bin|Shen, Xiaogang|Bai, Yifeng
PMID: 29542167
Journal: Oncotarget. 2017 Dec 8;9(17):13167-13180.
Title: Phthalate exposure promotes chemotherapeutic drug resistance in colon cancer cells.
Author: Chen, Hsin-Pao|Lee, Yung-Kuo|Huang, Shih Yin|Shi, Pei-Chun|Hsu, Ping-Chi|Chang, Chuan-Fa
PMID: 29568348
Journal: Cancer Discov. 2018 Apr;8(4):389-391.
Title: Advances on the BRAF Front in Colorectal Cancer.
Author: Janku, Filip
PMID: 29610287
Journal: Cell Physiol Biochem. 2018;46(2):829-846.
Title: Gambogic Acid Efficiently Kills Stem-Like Colorectal Cancer Cells by Upregulating ZFP36 Expression.
Author: Wei, Fang|Zhang, Tong|Yang, Zhi|Wei, Jian-Chang|Shen, Hong-Fen|Xiao, Dong|Wang, Qiang|Yang, Ping|Chen, Hua-Cui|Hu, He|Chen, Zhuan-Peng|Huang, Qing|Li, Wang-Lin|Cao, Jie
PMID: 29627822
Journal: Oncogene. 2018 Jul;37(28):3790-3805.
Title: Collagen IV-conveyed signals can regulate chemokine production and promote liver metastasis.
Author: Vaniotis, George|Rayes, Roni F|Qi, Shu|Milette, Simon|Wang, Ni|Perrino, Stephanie|Bourdeau, France|Nystrom, Hanna|He, Yi|Lamarche-Vane, Nathalie|Brodt, Pnina
PMID: 29651051
Journal: Oncotarget. 2018 Mar 30;9(24):17066-17077.
Title: Ferric citrate and ferric EDTA but not ferrous sulfate drive amphiregulin-mediated activation of the MAP kinase ERK in gut epithelial cancer cells.
Author: Scheers, Nathalie M|Pereira, Dora I A|Faria, Nuno|Powell, Jonathan J
PMID: 29682205
Journal: Eur Rev Med Pharmacol Sci. 2018 Apr;22(7):1922-1928.
Title: Peroxiredoxin1 promotes cell proliferation, migration and invasion of colorectal cancer via p38MAPK signaling.
Author: Cong, N|Huang, W|Yuan, J-P|Li, G-Z|Zhai, G-S|Li, B-S
PMID: 29687844
Journal: Int J Mol Med. 2018 Jul;42(1):665-673.
Title: MicroRNA125 inhibits RKO colorectal cancer cell growth by targeting VEGF.
Author: Wu, Qi-Bing|Chen, Jing|Zhu, Jia-Wei|Yin, Xin|You, He-Yang|Lin, Yi-Rong|Zhu, Hua-Qing
PMID: 29693153
Journal: Oncotarget. 2018 Jan 8;9(28):20089-20102.
Title: Baicalein and baicalin inhibit colon cancer using two distinct fashions of apoptosis and senescence.
Author: Dou, Jie|Wang, Zhou|Ma, Leon|Peng, Bo|Mao, Ke|Li, Chengqin|Su, Mengqi|Zhou, Changlin|Peng, Guangyong
PMID: 29732005
Journal: Cell Calcium. 2018 Jun;72:70-80.
Title: Oncogenic KRAS suppresses store-operated Ca(2+) entry and ICRAC through ERK pathway-dependent remodelling of STIM expression in colorectal cancer cell lines.
Author: Pierro, Cristina|Zhang, Xuexin|Kankeu, Cynthia|Trebak, Mohamed|Bootman, Martin D|Roderick, H Llewelyn
PMID: 29748135
Journal: Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt B):2769-2784.
Title: LIFR promotes tumor angiogenesis by up-regulating IL-8 levels in colorectal cancer.
Author: Wu, Hao-Xuan|Cheng, Xi|Jing, Xiao-Qian|Ji, Xiao-Pin|Chen, Xian-Ze|Zhang, Ya-Qi|He, Yong-Gang|Liu, Kun|Ye, Feng|Sun, Han-Xing|Gao, Hao-Ji|Song, Zi-Jia|Wu, Huo|Zhang, Xiao-Jian|Zhang, Tao|Zhao, Ren
PMID: 29751081
Journal: Br J Cancer. 2018 May 14. pii: 10.1038/s41416-018-0086-x.
Title: AZ304, a novel dual BRAF inhibitor, exerts anti-tumour effects in colorectal cancer independently of BRAF genetic status.
Author: Ma, Rui|Xu, Ling|Qu, Xiujuan|Che, Xiaofang|Zhang, Ye|Fan, Yibo|Li, Ce|Guo, Tianshu|Hou, Kezuo|Hu, Xuejun|Drew, Lisa|Shen, Minhui|Cheung, Tony|Liu, Yunpeng
PMID: 29755114
Journal: J Cell Biochem. 2018 Sep;119(9):7256-7263.
Title: Proliferation and invasion of colon cancer cells are suppressed by knockdown of TOP2A.
Author: Zhang, Rui|Xu, Jian|Zhao, Jian|Bai, Jing H
PMID: 29761838
Journal: Biomed Pharmacother. 2018 Aug;104:94-101.
Title: The protective role of all-transretinoic acid (ATRA) against colorectal cancer development is achieved via increasing miR-3666 expression and decreasing E2F7 expression.
Author: Liu, Weihong|Song, Yanqiu|Zhang, Chenggui|Gao, Pengfei|Huang, Bisheng|Yang, Jianfang
PMID: 29772445
Journal: Apoptosis. 2018 Jun;23(5-6):356-374.
Title: Down-regulating IL-6/GP130 targets improved the anti-tumor effects of 5-fluorouracil in colon cancer.
Author: Li, Sanhong|Tian, Jilai|Zhang, Hongming|Zhou, Shoubing|Wang, Xiyong|Zhang, Lei|Yang, Jiapeng|Zhang, Zhigang|Ji, Zhenling
PMID: 29777330
Journal: Oncol Rep. 2018 Jul;40(1):554-564.
Title: MicroRNA-485 plays tumour-suppressive roles in colorectal cancer by directly targeting GAB2.
Author: Li, Jibin|Xu, Jian|Yan, Xiaofei|Jin, Keer|Li, Wenya|Zhang, Rui
PMID: 29781037
Journal: Nat Med. 2018 Jul;24(7):961-967.
Title: SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo.
Author: Mainardi, Sara|Mulero-Sanchez, Antonio|Prahallad, Anirudh|Germano, Giovanni|Bosma, Astrid|Krimpenfort, Paul|Lieftink, Cor|Steinberg, Jeffrey D|de Wit, Niels|Goncalves-Ribeiro, Samuel|Nadal, Ernest|Bardelli, Alberto|Villanueva, Alberto|Bernards, Rene
PMID: 29808006
Journal: Mol Carcinog. 2018 Oct;57(10):1300-1310.
Title: AKR1B10 activates diacylglycerol (DAG) second messenger in breast cancer cells.
Author: Huang, Chenfei|Cao, Zhe|Ma, Jun|Shen, Yi|Bu, Yiwen|Khoshaba, Ramina|Shi, Guiyuan|Huang, Dan|Liao, Duan-Fang|Ji, Haitao|Jin, Junfei|Cao, Deliang
PMID: 29846015
Journal: Med Sci Monit. 2018 Jun 3;24:3710-3719.
Title: Quinalizarin Induces Apoptosis through Reactive Oxygen Species (ROS)-Mediated Mitogen-Activated Protein Kinase (MAPK) and Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathways in Colorectal Cancer Cells.
Author: Meng, Ling-Qi|Wang, Yue|Luo, Ying-Hua|Piao, Xian-Ji|Liu, Chang|Wang, Yue|Zhang, Yi|Wang, Jia-Ru|Wang, Hao|Xu, Wan-Ting|Liu, Yang|Wu, Yi-Qin|Sun, Hu-Nan|Han, Ying-Hao|Jin, Mei-Hua|Shen, Gui-Nan|Fang, Nan-Zhu|Jin, Cheng-Hao
PMID: 29860266
Journal: J Transl Med. 2018 Jun 4;16(1):150.
Title: Granulin epithelin precursor promotes colorectal carcinogenesis by activating MARK/ERK pathway.
Author: Pan, Yi|Cheung, Siu Tim|Tong, Joanna Hung Man|Tin, Ka Yee|Kang, Wei|Lung, Raymond Wai Ming|Wu, Feng|Li, Hui|Ng, Simon Siu Man|Mak, Tony Wing Chung|To, Ka Fai|Chan, Anthony Wing Hung
PMID: 29866109
Journal: Cell Commun Signal. 2018 Jun 8;16(1):26.
Title: Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1alpha axis.
Author: Li, Qingguo|Li, Yaqi|Liang, Lei|Li, Jing|Luo, Dakui|Liu, Qi|Cai, Sanjun|Li, Xinxiang
PMID: 29884183
Journal: Oxid Med Cell Longev. 2018 May 20;2018:3271617.
Title: 3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1,2,4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation.
Author: Xu, Li-Li|Liu, Tian|Wang, Lei|Li, Li|Wu, Yu-Feng|Li, Cui-Cui|Di, Bin|You, Qi-Dong|Jiang, Zheng-Yu
PMID: 29887940
Journal: Oncol Rep. 2018 Aug;40(2):704-714.
Title: Fibroblast growth factor 18 promotes the growth, migration and invasion of MDAMB231 cells.
Author: Yu, Ziyi|Lou, Longquan|Zhao, Yi
PMID: 29901199
Journal: Sci Rep. 2018 Jun 18;8(1):9296.
Title: PTPRS Regulates Colorectal Cancer RAS Pathway Activity by Inactivating Erk and Preventing Its Nuclear Translocation.
Author: Davis, Thomas B|Yang, Mingli|Schell, Michael J|Wang, Heiman|Ma, Le|Pledger, W Jack|Yeatman, Timothy J
PMID: 29915291
Journal: J Transl Med. 2018 Jun 19;16(1):169.
Title: CHIP functions as an oncogene by promoting colorectal cancer metastasis via activation of MAPK and AKT signaling and suppression of E-cadherin.
Author: Xu, Jingjing|Zhou, Jun|Dai, Hanjue|Liu, Fei|Li, Wenjing|Wang, Wenjuan|Guo, Feng
PMID: 29921293
Journal: Eur Rev Med Pharmacol Sci. 2018 Jun;22(12):3779-3788.
Title: Study on the function and mechanism of long non-coding RNA DMTF1v4 in the occurrence of colon cancer.
Author: Zhuang, S-T|Cai, Y-J|Gao, H-C|Qiu, J-F|Zeng, L|Zheng, W-J
PMID: 29949153
Journal: Cancer Res. 2018 Sep 1;78(17):4839-4852.
Title: Erbin Suppresses KSR1-Mediated RAS/RAF Signaling and Tumorigenesis in Colorectal Cancer.
Author: Stevens, Payton D|Wen, Yang-An|Xiong, Xiaopeng|Zaytseva, Yekaterina Y|Li, Austin T|Wang, Chi|Stevens, Ashley T|Farmer, Trevor N|Gan, Tong|Weiss, Heidi L|Inagaki, Masaki|Marchetto, Sylvie|Borg, Jean-Paul|Gao, Tianyan
PMID: 29980571
Journal: Carcinogenesis. 2018 Jul 3;39(7):911-920.
Title: Nitric oxide-donating aspirin (NO-Aspirin) suppresses lung tumorigenesis in vitro and in vivo and these effects are associated with modulation of the EGFR signaling pathway.
Author: Song, Jung Min|Upadhyaya, Pramod|Kassie, Fekadu
PMID: 29982425
Journal: Int J Cancer. 2018 Jul 10.
Title: Clinical significance and biological function of WD repeat domain 54 as an oncogene in colorectal cancer.
Author: Yuan, Yuncang|Qi, Guoxiang|Shen, Hao|Guo, Aizhen|Cao, Fuao|Zhu, Yan|Xiao, Chunjie|Chang, Wenjun|Zheng, Shangyong
PMID: 29987896
Journal: Br J Cancer. 2018 Jul 10. pii: 10.1038/s41416-018-0174-y.
Title: ERK and p38MAPK combine to improve survival in patients with BRAF mutant colorectal cancer.
Author: Roseweir, Antonia K|Halcrow, Elaine S|Chichilo, Sergey|Powell, Arfon Gmt|McMillan, Donald C|Horgan, Paul G|Edwards, Joanne
PMID: 29988110
Journal: Onco Targets Ther. 2018 Jul 2;11:3765-3774.
Title: Angiogenesis and vasculogenic mimicry are inhibited by 8-Br-cAMP through activation of the cAMP/PKA pathway in colorectal cancer.
Author: Wang, Sen|Zhang, Zhiyuan|Qian, Wenwei|Ji, Dongjian|Wang, Qingyuan|Ji, Bing|Zhang, Yue|Zhang, Chuan|Sun, Ye|Zhu, Chunyan|Sun, Yueming
PMID: 29997437
Journal: PLoS One. 2018 Jul 12;13(7):e0200163.
Title: Downregulation of PIK3CA via antibody-esiRNA-complexes suppresses human xenograft tumor growth.
Author: Baumer, Nicole|Rehkamper, Jan|Appel, Neele|Terheyden, Lisa|Hartmann, Wolfgang|Wardelmann, Eva|Buchholz, Frank|Muller-Tidow, Carsten|Berdel, Wolfgang E|Baumer, Sebastian
PMID: 30001368
Journal: Mol Cell Endocrinol. 2018 Jul 21. pii: S0303-7207(18)30221-1.
Title: Potential therapeutic targets for growth arrest of colorectal cancer cells exposed to PTHrP.
Author: Martin, Maria Julia|Gigola, Graciela|Zwenger, Ariel|Carriquiriborde, Martin|Gentil, Florencia|Gentili, Claudia
PMID: 30009852
Journal: Int J Oncol. 2018 Sep;53(3):1183-1192.
Title: Silencing GOLPH3 gene expression reverses resistance to cisplatin in HT29 colon cancer cells via multiple signaling pathways.
Author: Zhou, Zhi-Ping|Wang, Lin-Pei|Hong, Zhong-Shi|Qiu, Cheng-Zhi|Wang, Ming-Zhen|Chen, Zhi-Xiong|Tang, Long-Feng|Yu, Wai-Shi|Wang, Chun-Xiao
PMID: 30015866
Journal: J Pathol Transl Med. 2018 Sep;52(5):298-306.
Title: Prognostic Significance of EPHB2 Expression in Colorectal Cancer Progression.
Author: Jang, Bo Gun|Kim, Hye Sung|Chang, Weon Young|Bae, Jeong Mo|Kang, Gyeong Hoon
PMID: 30016858
Journal: Stem Cell Reports. 2018 Aug 14;11(2):410-424.
Title: The Zinc Finger Transcription Factor PLAGL2 Enhances Stem Cell Fate and Activates Expression of ASCL2 in Intestinal Epithelial Cells.
Author: Strubberg, Ashlee M|Veronese Paniagua, Daniel A|Zhao, Tingting|Dublin, Leeran|Pritchard, Thomas|Bayguinov, Peter O|Fitzpatrick, James A J|Madison, Blair B
PMID: 30017821
Journal: Dev Reprod. 2018 Jun;22(2):133-142.
Title: Combination of BEZ235 and Metformin Has Synergistic Effect on Cell Viability in Colorectal Cancer Cells.
Author: Kim, Taewan|Kim, Taehyung|Choi, Soonyoung|Ko, Hyeran|Park, Deokbae|Lee, Youngki
PMID: 30023463
Journal: Am J Pathol. 2018 Oct;188(10):2236-2250.
Title: Expression Profile of LGR5 and Its Prognostic Significance in Colorectal Cancer Progression.
Author: Jang, Bo Gun|Kim, Hye Sung|Chang, Weon Young|Bae, Jeong Mo|Kim, Woo Ho|Kang, Gyeong Hoon
PMID: 30036518
Journal: Recent Results Cancer Res. 2018;211:77-89.
Title: Vemurafenib.
Author: Garbe, Claus|Eigentler, Thomas K
PMID: 30069761
Journal: Phytomedicine. 2018 Jul 15;46:131-141.
Title: Turmeric extract, with absorbable curcumin, has potent anti-metastatic effect in vitro and in vivo.
Author: Li, Mingyue|Yue, Grace Gar-Lee|Tsui, Stephen Kwok-Wing|Fung, Kwok-Pui|Lau, Clara Bik-San
PMID: 30097113
Journal: PLoS One. 2018 Aug 17;13(8):e0200836.
Title: Molecular subtypes of colorectal cancer in pre-clinical models show differential response to targeted therapies: Treatment implications beyond KRAS mutations.
Author: Pal, Rekha|Wei, Ning|Song, Nan|Wu, Shaoyu|Kim, Rim S|Wang, Ying|Gavin, Patrick G|Lucas, Peter C|Srinivasan, Ashok|Allegra, Carmen J|Jacobs, Samuel A|Paik, Soonmyung|Schmitz, John C|Pogue-Geile, Katherine L
PMID: 30118499
Journal: Cancer Manag Res. 2018 Aug 1;10:2289-2301.
Title: Development of small-molecule therapeutics and strategies for targeting RAF kinase in BRAF-mutant colorectal cancer.
Author: Pan, Jing-Hua|Zhou, Hong|Zhu, Sheng-Bin|Huang, Jin-Lian|Zhao, Xiao-Xu|Ding, Hui|Pan, Yun-Long
PMID: 30122982
Journal: Biosci Rep. 2018 Sep 19;38(5). pii: BSR20180664.
Title: MiRNA-206 suppresses PGE2-induced colorectal cancer cell proliferation, migration, and invasion by targetting TM4SF1.
Author: Park, Young Ran|Seo, Seung Young|Kim, Se Lim|Zhu, Shi Mao|Chun, Sungkun|Oh, Jung-Mi|Lee, Min Ro|Kim, Seong Hun|Kim, In Hee|Lee, Seung Ok|Lee, Soo Teik|Kim, Sang Wook
PMID: 30135139
Journal: Mol Oncol. 2018 Sep 1.
Title: miR-372 and miR-373 enhance the stemness of colorectal cancer cells by repressing differentiation signaling pathways.
Author: Wang, Lu-Qin|Yu, Peng|Li, Bin|Guo, Yan-Hua|Liang, Zi-Rui|Zheng, Ling-Ling|Yang, Jian-Hua|Xu, Hui|Liu, Shun|Zheng, Li-Si|Zhou, Hui|Qu, Liang-Hu
PMID: 30171794
Journal: Oncogenesis. 2018 Sep 7;7(9):67.
Title: MEK inhibitors induce apoptosis via FoxO3a-dependent PUMA induction in colorectal cancer cells.
Author: Lin, Lin|Ding, Dapeng|Jiang, Yanmei|Li, Yan|Li, Shijun
PMID: 30190455
Journal: J Cancer. 2018 Jul 30;9(17):3032-3037.
Title: NCOA4-RET fusion in colorectal cancer: Therapeutic challenge using patient-derived tumor cell lines.
Author: Kim, Sun Young|Oh, Seiyoon Oh|Kim, Kyung|Lee, Jeeyun|Kang, SoYoung|Kim, Kyoung-Mee|Lee, WooYong|Kim, Seung Tae|Nam, Dohyun Nam
PMID: 30210625
Journal: J Exp Clin Cancer Res. 2018 Sep 19;37(1):231.
Title: HSCs-derived COMP drives hepatocellular carcinoma progression by activating MEK/ERK and PI3K/AKT signaling pathways.
Author: Li, Qing|Wang, Cong|Wang, Yufeng|Sun, Liankang|Liu, Zhikui|Wang, Liang|Song, Tao|Yao, Yingmin|Liu, Qingguang|Tu, Kangsheng
PMID: 30231922
Journal: Biomed Pharmacother. 2018 Sep 19;108:618-624.
Title: PMA treated THP-1-derived-IL-6 promotes EMT of SW48 through STAT3/ERK-dependent activation of Wnt/beta-catenin signaling pathway.
Author: Gao, Sikang|Hu, Junwu|Wu, Xiongwen|Liang, Zhihui
PMID: 30243096
Journal: Cell Death Dis. 2018 Sep 24;9(10):974.
Title: CCL19 suppresses angiogenesis through promoting miR-206 and inhibiting Met/ERK/Elk-1/HIF-1alpha/VEGF-A pathway in colorectal cancer.
Author: Xu, Zhuoqing|Zhu, Congcong|Chen, Chun|Zong, Yaping|Feng, Hao|Liu, Di|Feng, Wenqing|Zhao, Jingkun|Lu, Aiguo
PMID: 30250188
Journal: Oncol Lett. 2018 Oct;16(4):5131-5139.
Title: MiR-1260b inhibitor enhances the chemosensitivity of colorectal cancer cells to fluorouracil by targeting PDCD4/IGF1.
Author: Zhao, Jun|Cao, Jingjie|Zhou, Lurong|Du, Yunyi|Zhang, Xiaoling|Yang, Bo|Gao, Yangjun|Wang, Yu|Ma, Ning|Yang, Wei
PMID: 30250581
Journal: Onco Targets Ther. 2018 Sep 10;11:5647-5655.
Title: Upregulation of long noncoding RNA CCAT1-L promotes epithelial-mesenchymal transition in gastric adenocarcinoma.
Author: Fang, Hua|Liu, Hui-Min|Wu, Wei-Hua|Liu, Han|Pan, Yong|Li, Wen-Jun
PMID: 30254457
Journal: Cell Death Dis. 2018 Sep 26;9(10):1004.
Title: HMGB1 promotes ERK-mediated mitochondrial Drp1 phosphorylation for chemoresistance through RAGE in colorectal cancer.
Author: Huang, Chih-Yang|Chiang, Shu-Fen|Chen, William Tzu-Liang|Ke, Tao-Wei|Chen, Tsung-Wei|You, Ying-Shu|Lin, Chen-Yu|Chao, K S Clifford|Huang, Chih-Yang
PMID: 30258050
Journal: Br J Cancer. 2018 Oct;119(7):909.
Title: Reply to comment of "ERK and p38MAPK combine to improve survival in patients with BRAF mutant colorectal cancer".
Author: Roseweir, Antonia K|McMillan, Donald C|Edwards, Joanne
PMID: 30297771
Journal: Br J Cancer. 2018 Oct;119(7):908.
Title: Comment on "ERK and p38MAPK combine to improve survival in patients with BRAF mutant colorectal cancer".
Author: Uzunparmak, Burak|Sahin, Ibrahim H
PMID: 30297772
Journal: Int J Cancer. 2018 Oct 10.
Title: ERBB2 and KRAS Alterations Mediate Response to EGFR Inhibitors in Early Stage Gallbladder Cancer.
Author: Iyer, Prajish|Shrikhande, Shailesh V|Ranjan, Malika|Joshi, Asim|Gardi, Nilesh|Prasad, Ratnam|Dharavath, Bhasker|Thorat, Rahul|Salunkhe, Sameer|Sahoo, Bikram|Chandrani, Pratik|Kore, Hitesh|Mohanty, Bhabani|Chaudhari, Vikram|Choughule, Anuradha|Kawle, Dhana
PMID: 30304546
Journal: J Cell Physiol. 2018 Oct 12.
Title: ZC3H13 suppresses colorectal cancer proliferation and invasion via inactivating Ras-ERK signaling.
Author: Zhu, Dehua|Zhou, Jianping|Zhao, Jinbo|Jiang, Guiyang|Zhang, Xiupeng|Zhang, Yong|Dong, Ming
PMID: 30311220
Journal: Mol Ther Nucleic Acids. 2018 Sep 13;13:244-255.
Title: Antisense Oligonucleotides against miR-21 Inhibit the Growth and Metastasis of Colorectal Carcinoma via the DUSP8 Pathway.
Author: Ding, Tao|Cui, Panpan|Zhou, Ya|Chen, Chao|Zhao, Juanjuan|Wang, Hairong|Guo, Mengmeng|He, Zhixu|Xu, Lin
PMID: 30317164
Journal: J Sci Food Agric. 2018 Oct 24.
Title: Apoptotic effect of enterodiol, the final metabolite of edible lignans, in colorectal cancer cells.
Author: Shin, Min-Kyoung|Jeon, Yong-Deok|Jin, Jong-Sik
PMID: 30357838
Journal: Biomed Res Int. 2018 Sep 27;2018:2548378.
Title: alpha-Hederin Arrests Cell Cycle at G2/M Checkpoint and Promotes Mitochondrial Apoptosis by Blocking Nuclear Factor-kappaB Signaling in Colon Cancer Cells.
Author: Sun, Dongdong|Shen, Weixing|Zhang, Feng|Fan, Huisen|Tan, Jiani|Li, Liu|Xu, Changliang|Zhang, Haibin|Yang, Ye|Cheng, Haibo
PMID: 30363706
Journal: Oncol Rep. 2018 Oct 25.
Title: PEA15 promotes liver metastasis of colorectal cancer by upregulating the ERK/MAPK signaling pathway.
Author: Tang, Bo|Liang, Wenjin|Liao, Yong|Li, Zeming|Wang, Yan|Yan, Chao
PMID: 30365128
Journal: Cell Cycle. 2018 Nov 1.
Title: Up-regulation of microRNA-497 inhibits the proliferation, migration and invasion but increases the apoptosis of multiple myeloma cells through the MAPK/ERK signaling pathway by targeting Raf-1.
Author: Ye, Cheng-Yu|Zheng, Cui-Ping|Ying, Wei-Wei|Weng, Shan-Shan
PMID: 30382763
Journal: BMC Cancer. 2018 Nov 1;18(1):1056.
Title: The small organic molecule C19 binds and strengthens the KRAS4b-PDEdelta complex and inhibits growth of colorectal cancer cells in vitro and in vivo.
Author: Cruz-Nova, Pedro|Schnoor, Michael|Correa-Basurto, Jose|Bello, Martiniano|Briseno-Diaz, Paola|Rojo-Dominguez, Arturo|Ortiz-Mendoza, Carlos M|Guerrero-Aguirre, Jorge|Garcia-Vazquez, Francisco J|Hernandez-Rivas, Rosaura|Thompson-Bonilla, Maria Del Rocio|Varg
PMID: 30382908