Primary Site >> Colorectal Cancer
Gene >> EPHB2
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Ref: Protein kinase C beta 1 and protein kinase C beta 2 activate p57 mitogen-activated protein kinase and block differentiation in colon carcinoma cells. PMID: 8732668 |
Ref: Elevated urokinase-type plasminogen activator receptor expression in a colon cancer cell line is due to a constitutively activated extracellular signal-regulated kinase-1-dependent signaling cascade. PMID: 9191056 Ref: ErbB kinases and NDF signaling in human prostate cancer cells. PMID: 9400997 |
Ref: Oncogenic ras induces gastrin gene expression in colon cancer. PMID: 9797369 |
Ref: Differential contribution of the ERK and JNK mitogen-activated protein kinase cascades to Ras transformation of HT1080 fibrosarcoma and DLD-1 colon carcinoma cells. PMID: 10086335 Ref: Mitogen-activated protein kinase activation regulates intestinal epithelial differentiation. PMID: 10220499 Ref: Carcinogen and dietary lipid regulate ras expression and localization in rat colon without affecting farnesylation kinetics. PMID: 10334194 Ref: Glycine-extended gastrin exerts growth-promoting effects on human colon cancer cells. PMID: 10404512 Ref: Extracellular signal-regulated kinase activation is required for up-regulation of vascular endothelial growth factor by serum starvation in human colon carcinoma cells. PMID: 10519388 Ref: Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. PMID: 10581086 Ref: 1,25-Dihydroxyvitamin D(3) stimulates activator protein-1-dependent Caco-2 cell differentiation. PMID: 10585423 |
Ref: Bile acid-induced activation of activator protein-1 requires both extracellular signal-regulated kinase and protein kinase C signaling. PMID: 10748108 Ref: Defective cleavage of membrane bound TGFalpha leads to enhanced activation of the EGF receptor in malignant cells. PMID: 10773880 Ref: Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells. PMID: 10910078 Ref: [Deregulation of intracellular signal pathways in colorectal carcinoma]. PMID: 10929640 Ref: Induction of prostaglandin endoperoxide synthase 2 by mitogen-activated protein kinase cascades. PMID: 11085935 |
Ref: Genomic structure and loss of heterozygosity of EPHB2 in colorectal cancer. PMID: 11166921 Ref: n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in colonocytes. PMID: 11287318 Ref: Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells. PMID: 11322385 Ref: Alterations of MAPK activities associated with intestinal cell differentiation. PMID: 11394874 Ref: Butyrate and propionate downregulate ERK phosphorylation in HT-29 colon carcinoma cells prior to differentiation. PMID: 11535873 Ref: Upregulation of non-mutated H-ras and its upstream and downstream signaling proteins in colorectal cancer. PMID: 11605075 Ref: Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells. PMID: 11781819 |
Ref: Autocrine heregulin generates growth factor independence and blocks apoptosis in colon cancer cells. PMID: 11791178 Ref: Direct integrin alphavbeta6-ERK binding: implications for tumour growth. PMID: 11857080 Ref: Coexpression of ephrin-Bs and their receptors in colon carcinoma. PMID: 11920461 Ref: Differential modulation of zinc-stimulated p21(Cip/WAF1) and cyclin D1 induction by inhibition of PI3 kinase in HT-29 colorectal cancer cells. PMID: 11989975 Ref: Integrin expression in colon cancer cells is regulated by the cytoplasmic domain of the beta6 integrin subunit. PMID: 11992542 Ref: Phorbol 12-myristate 13-acetate up-regulates the transcription of MUC2 intestinal mucin via Ras, ERK, and NF-kappa B. PMID: 12077118 Ref: Extracellular zinc stimulates ERK-dependent activation of p21(Cip/WAF1) and inhibits proliferation of colorectal cancer cells. PMID: 12381673 Ref: Perturbation by geraniol of cell membrane permeability and signal transduction pathways in human colon cancer cells. PMID: 12388655 Ref: Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. PMID: 12408869 Ref: Therapeutics targeting signal transduction for patients with colorectal carcinoma. PMID: 12421735 Ref: The role of Raf kinases in malignant transformation. PMID: 14987392 |
Ref: Proteomic profiling of proteins associated with urokinase plasminogen activator receptor in a colon cancer cell line using an antisense approach. PMID: 12627382 Ref: Integrin alpha2 and extracellular signal-regulated kinase are functionally linked in highly malignant autocrine transforming growth factor-alpha-driven colon cancer cells. PMID: 12657625 Ref: Platelet-activating factor activates mitogen-activated protein kinases, inhibits proliferation, induces differentiation and suppresses the malignant phenotype of human colon carcinoma cells. PMID: 12687020 Ref: Growth-promoting effect of muscarinic acetylcholine receptors in colon cancer cells. PMID: 12748850 Ref: Raf proteins and cancer: B-Raf is identified as a mutational target. PMID: 12781369 Ref: Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids. PMID: 12802055 Ref: The ERK pathway involves positive and negative regulations of HT-29 colorectal cancer cell growth by extracellular zinc. PMID: 12816758 Ref: The roles of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells. PMID: 12819185 Ref: A pharmacodynamic study of the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in metastatic colorectal cancer patients. PMID: 12855618 Ref: Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells. PMID: 12865932 Ref: Gastrin and EGF synergistically induce cyclooxygenase-2 expression in Swiss 3T3 fibroblasts that express the CCK2 receptor. PMID: 12891702 Ref: ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility. PMID: 12892714 Ref: The chemopreventive bioflavonoid apigenin modulates signal transduction pathways in keratinocyte and colon carcinoma cell lines. PMID: 14608117 Ref: Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK. PMID: 14623871 Ref: Elevated ERK-MAP kinase activity protects the FOS family member FRA-1 against proteasomal degradation in colon carcinoma cells. PMID: 14625389 |
Ref: Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers. PMID: 14726470 Ref: The complex genetic epidemiology of prostate cancer. PMID: 14749351 Ref: Lack of p38 MAP kinase activation in TRAIL-resistant cells is not related to the resistance to TRAIL-mediated cell death. PMID: 14749540 Ref: EphB2 as a therapeutic antibody drug target for the treatment of colorectal cancer. PMID: 14871799 Ref: Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-kappaB-dependent pathway. PMID: 14981539 Ref: Induction of S-phase arrest and p21 overexpression by a small molecule 2[[3-(2,3-dichlorophenoxy)propyl] amino]ethanol in correlation with activation of ERK. PMID: 15122344 Ref: Different effects of point mutations within the B-Raf glycine-rich loop in colorectal tumors on mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase and nuclear factor kappaB pathway and cellular tra PMID: 15150094 Ref: Curcumin induces c-jun N-terminal kinase-dependent apoptosis in HCT116 human colon cancer cells. PMID: 15256484 Ref: Autocrine transforming growth factor alpha regulates cell adhesion by multiple signaling via specific phosphorylation sites of p70S6 kinase in colon cancer cells. PMID: 15304500 Ref: EGF-receptor related protein causes cell cycle arrest and induces apoptosis of colon cancer cells in vitro and in vivo. PMID: 15517892 Ref: Extracellular pressure stimulates colon cancer cell proliferation via a mechanism requiring PKC and tyrosine kinase signals. PMID: 15548175 Ref: Inhibition of extracellular-signal regulated kinases 1/2 is required for apoptosis of human colon cancer cells in vitro by sulindac metabolites. PMID: 15548677 Ref: [Complex forms of immune insufficiency to some cytokines (TNF-alpha, interferons) in colorectal cancers as exemplified by the COLO 205 cell line. Mechanism of resistance with special reference to signaling proteins and cytokines]. PMID: 15577750 Ref: p21Cip/WAF1 activation is an important factor for the ERK pathway dependent anti-proliferation of colorectal cancer cells. PMID: 15665589 |
Ref: The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1. PMID: 15590642 Ref: Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cells. PMID: 15618237 Ref: Physiology and pathophysiology of proteinase-activated receptors (PARs): PAR-2-mediated proliferation of colon cancer cell. PMID: 15655297 Ref: The Raf kinase inhibitor BAY 43-9006 reduces cellular uptake of platinum compounds and cytotoxicity in human colorectal carcinoma cell lines. PMID: 15655409 Ref: Gastrin promotes human colon cancer cell growth via CCK-2 receptor-mediated cyclooxygenase-2 induction and prostaglandin E2 production. PMID: 15655524 Ref: Selective inhibitors of MEK1/ERK44/42 and p38 mitogen-activated protein kinases potentiate apoptosis induction by sulindac sulfide in human colon carcinoma cells. PMID: 15657353 Ref: Mutations of the BRAF gene in ulcerative colitis-related colorectal carcinoma. PMID: 15704157 Ref: Butyrate-induced differentiation of colon cancer cells is PKC and JNK dependent. PMID: 15810631 Ref: DCC association with lipid rafts is required for netrin-1-mediated axon guidance. PMID: 15811950 Ref: Essential role of p38gamma in K-Ras transformation independent of phosphorylation. PMID: 15851477 Ref: The MAPK signalling pathways and colorectal cancer. PMID: 15863380 Ref: Supra-additive growth inhibition by a celecoxib analogue and carboxyamido-triazole is primarily mediated through apoptosis. PMID: 15867384 Ref: Ornithine decarboxylase, mitogen-activated protein kinase and matrix metalloproteinase-2 expressions in human colon tumors. PMID: 15918191 Ref: Smad7 induces tumorigenicity by blocking TGF-beta-induced growth inhibition and apoptosis. PMID: 15922743 Ref: The SRC-induced mesenchymal state in late-stage colon cancer cells. PMID: 15942195 Ref: Prostaglandin E2 activates mitogen-activated protein kinase/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner. PMID: 16024629 Ref: EphB2 is a prognostic factor in colorectal cancer. PMID: 16033834 Ref: Garcinol modulates tyrosine phosphorylation of FAK and subsequently induces apoptosis through down-regulation of Src, ERK, and Akt survival signaling in human colon cancer cells. PMID: 16052481 Ref: Gastrin suppresses growth of CCK2 receptor expressing colon cancer cells by inducing apoptosis in vitro and in vivo. PMID: 16143134 Ref: Induction of apoptotic cell death by 2'-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-kappaB in TNF-alpha-treated SW620 colon cancer cells. PMID: 16143316 Ref: [Effect of NGX6 on gene expression profile of colon carcinoma cell line HT-29]. PMID: 16159426 Ref: EphB2 expression across 138 human tumor types in a tissue microarray: high levels of expression in gastrointestinal cancers. PMID: 16166419 Ref: Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors. PMID: 16288001 Ref: Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea. PMID: 16288056 Ref: Chemotherapy regimen GOLF induces apoptosis in colon cancer cells through multi-chaperone complex inactivation and increased Raf-1 ubiquitin-dependent degradation. PMID: 16294035 Ref: EGCG inhibits activation of HER3 and expression of cyclooxygenase-2 in human colon cancer cells. PMID: 16416603 |
Ref: Glycine-extended gastrin stimulates proliferation and inhibits apoptosis in colon cancer cells via cyclo-oxygenase-independent pathways. PMID: 16169610 Ref: Curcumin inhibits human colon cancer cell growth by suppressing gene expression of epidermal growth factor receptor through reducing the activity of the transcription factor Egr-1. PMID: 16170359 Ref: p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1. PMID: 16170570 Ref: Molecular signaling cascade in DNA bisintercalator, echinomycin-induced apoptosis of HT-29 cells: evidence of the apoptotic process via activation of the cytochrome c-ERK-caspase-3 pathway. PMID: 16214385 Ref: Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signalling. PMID: 16241905 Ref: Reduced expression of EphB2 that parallels invasion and metastasis in colorectal tumours. PMID: 16272170 Ref: Integrin alpha2-mediated ERK and calpain activation play a critical role in cell adhesion and motility via focal adhesion kinase signaling: identification of a novel signaling pathway. PMID: 16461767 Ref: APC inhibits ERK pathway activation and cellular proliferation induced by RAS. PMID: 16478791 Ref: RRR-alpha-tocopherol succinate down-regulates oncogenic Ras signaling. PMID: 16505104 Ref: Desferrioxamine, an iron chelator, enhances HIF-1alpha accumulation via cyclooxygenase-2 signaling pathway. PMID: 16527254 Ref: The BH3-only protein, PUMA, is involved in oxaliplatin-induced apoptosis in colon cancer cells. PMID: 16595125 Ref: Effects of extracts from two Native American plants on proliferation of human breast and colon cancer cell lines in vitro. PMID: 16596206 Ref: Interleukin-6 production induced by leptin treatment promotes cell proliferation in an Apc (Min/+) colon epithelial cell line. PMID: 16597643 Ref: Proline oxidase activates both intrinsic and extrinsic pathways for apoptosis: the role of ROS/superoxides, NFAT and MEK/ERK signaling. PMID: 16619034 Ref: Arachidonic acid-induced gene expression in colon cancer cells. PMID: 16704987 Ref: Folic acid and its metabolites modulate IGF-I receptor gene expression in colon cancer cells in a p53-dependent manner. PMID: 16728583 Ref: EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis. PMID: 16740153 Ref: Stress-induced phosphorylation of caveolin-1 and p38, and down-regulation of EGFr and ERK by the dietary lectin jacalin in two human carcinoma cell lines. PMID: 16817319 Ref: Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. PMID: 16959882 Ref: Different modulation of TRAIL-induced apoptosis by inhibition of pro-survival pathways in TRAIL-sensitive and TRAIL-resistant colon cancer cells. PMID: 17113582 |
Ref: High EPHB2 mutation rate in gastric but not endometrial tumors with microsatellite instability. PMID: 16819508 Ref: MAGI-3 regulates LPA-induced activation of Erk and RhoA. PMID: 16904289 Ref: Antitumor activity of HER1/EGFR tyrosine kinase inhibitor erlotinib, alone and in combination with CPT-11 (irinotecan) in human colorectal cancer xenograft models. PMID: 16937104 Ref: Conjugated linoleic acid inhibits Caco-2 cell growth via ERK-MAPK signaling pathway. PMID: 16963252 Ref: L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells. PMID: 17030349 Ref: Elevated gadd153/chop expression during resveratrol-induced apoptosis in human colon cancer cells. PMID: 17049495 Ref: RhoE interferes with Rb inactivation and regulates the proliferation and survival of the U87 human glioblastoma cell line. PMID: 17182035 Ref: Anti-EGFR and ErbB-2 antibodies attenuate cyclooxygenase-2 expression and cooperatively inhibit survival of human colon cancer cells. PMID: 17189670 Ref: Colorectal serrated adenocarcinoma. PMID: 17204027 Ref: NF-kappaB pathway is involved in griseofulvin-induced G2/M arrest and apoptosis in HL-60 cells. PMID: 17226769 Ref: A novel mechanism of resistance to epidermal growth factor receptor antagonism in vivo. PMID: 17234777 Ref: Inhibition of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway decreases DNA methylation in colon cancer cells. PMID: 17307743 Ref: Basic transcription factor 3 (BTF3) regulates transcription of tumor-associated genes in pancreatic cancer cells. PMID: 17312387 Ref: BMP-induced growth suppression in colon cancer cells is mediated by p21WAF1 stabilization and modulated by RAS/ERK. PMID: 17317101 Ref: Decreased MAPK- and PGE2-dependent IL-11 production in Gialpha2-/- colonic myofibroblasts. PMID: 17332478 Ref: Profiling of selenomethionine responsive genes in colon cancer by microarray analysis. PMID: 17374985 Ref: The inhibition of Wnt/beta-catenin signalling by 1alpha,25-dihydroxyvitamin D3 is abrogated by Snail1 in human colon cancer cells. PMID: 17395983 Ref: Cyclo-oxygenase-independent inhibition of apoptosis and stimulation of proliferation by leptin in human colon cancer cells. PMID: 17406816 Ref: Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells. PMID: 17478078 Ref: Inducing effects of hepatocyte growth factor on the expression of vascular endothelial growth factor in human colorectal carcinoma cells through MEK and PI3K signaling pathways. PMID: 17531111 Ref: Lysophosphatidic acid prevents apoptosis of Caco-2 colon cancer cells via activation of mitogen-activated protein kinase and phosphorylation of Bad. PMID: 17544220 Ref: The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells. PMID: 17583570 Ref: RAGE activation by S100P in colon cancer stimulates growth, migration, and cell signaling pathways. PMID: 17587138 Ref: The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells. PMID: 17631291 Ref: HETEs enhance IL-1-mediated COX-2 expression via augmentation of message stability in human colonic myofibroblasts. PMID: 17640979 Ref: [Effects of extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway activation on proliferation and cell cycle associated genes in human colon cancer cells]. PMID: 17650425 Ref: Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer. PMID: 17671177 Ref: Antiapoptotic effects of progastrin on pancreatic cancer cells are mediated by sustained activation of nuclear factor-{kappa}B. PMID: 17671195 Ref: Keratinocyte growth factor-transfection-stimulated adhesion of colorectal cancer cells to extracellular matrices. PMID: 17706640 Ref: Thermal sensitization through ROS modulation: a strategy to improve the efficacy of hyperthermic intraperitoneal chemotherapy. PMID: 17723891 Ref: 4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase. PMID: 17880056 Ref: Microsatellite unstable colorectal cancer cell lines with truncating TGFbetaRII mutations remain sensitive to endogenous TGFbeta. PMID: 17893910 Ref: EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells. PMID: 17906625 Ref: Nitric oxide inactivates the retinoblastoma pathway in chronic inflammation. PMID: 17909036 Ref: [Regulation of promatrilysin expression by tissue factor/actived coagulation factor VII complex in LoVo colon cancer cell line]. PMID: 17940558 Ref: BMP suppresses PTEN expression via RAS/ERK signaling. PMID: 18059158 Ref: Bilirubin inhibits tumor cell growth via activation of ERK. PMID: 18073533 Ref: The EPH receptor Bs (EPHBs) promoters are unmethylated in colon and ovarian cancers. PMID: 18281782 Ref: Proteasome inhibition potentiates the cytotoxic effects of hyperthermia in HT-29 colon cancer cells through inhibition of heat shock protein 27. PMID: 18337621 Ref: Therapeutic strategies for targeting BRAF in human cancer. PMID: 18473997 |
Ref: Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models. PMID: 17599042 Ref: Synergistic effects of a combination of dietary factors sulforaphane and (-) epigallocatechin-3-gallate in HT-29 AP-1 human colon carcinoma cells. PMID: 17657594 Ref: Regulation of apoptosis by modified naringenin derivatives in human colorectal carcinoma RKO cells. PMID: 18004724 Ref: Saccharomyces boulardii interferes with Shigella pathogenesis by postinvasion signaling events. PMID: 18032477 Ref: Polymeric black tea polyphenols inhibit 1,2-dimethylhydrazine induced colorectal carcinogenesis by inhibiting cell proliferation via Wnt/beta-catenin pathway. PMID: 18037152 Ref: Phorbol ester up-regulates phospholipase D1 but not phospholipase D2 expression through a PKC/Ras/ERK/NFkappaB-dependent pathway and enhances matrix metalloproteinase-9 secretion in colon cancer cells. PMID: 18084005 Ref: Suppression of v-Src transformation by andrographolide via degradation of the v-Src protein and attenuation of the Erk signaling pathway. PMID: 18086662 Ref: Comparative examination of anti-proliferative activities of (-)-epigallocatechin gallate and (--)-epigallocatechin against HCT116 colorectal carcinoma cells. PMID: 18175946 Ref: Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon. PMID: 18271008 Ref: A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization. PMID: 18305109 Ref: The BH3-only protein PUMA is involved in green tea polyphenol-induced apoptosis in colorectal cancer cell lines. PMID: 18367875 Ref: ANTI-ADHESION evolves to a promising therapeutic concept in oncology. PMID: 18393855 Ref: Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6. PMID: 18454176 Ref: Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells. PMID: 18520051 Ref: Analysis of the K-ras/B-raf/Erk signal cascade, p53 and CMAP as markers for tumor progression in colorectal cancer patients. PMID: 18575712 Ref: Alpha2beta1 integrin regulates lineage commitment in multipotent human colorectal cancer cells. PMID: 18664572 Ref: Germline EPHB2 receptor variants in familial colorectal cancer. PMID: 18682749 Ref: Overexpression of EphA4 gene and reduced expression of EphB2 gene correlates with liver metastasis in colorectal cancer. PMID: 18695888 Ref: PAR2 triggers IL-8 release via MEK/ERK and PI3-kinase/Akt pathways in GI epithelial cells. PMID: 18854173 Ref: Gamma-secretase inhibition combined with platinum compounds enhances cell death in a large subset of colorectal cancer cells. PMID: 18950493 Ref: Two-marker protein profile predicts poor prognosis in patients with early rectal cancer. PMID: 18985041 |
Ref: Aberrant expression of proteinase-activated receptor 4 promotes colon cancer cell proliferation through a persistent signaling that involves Src and ErbB-2 kinase. PMID: 19058300 Ref: Intra-hippocampal administration of the VEGF receptor blocker PTK787/ZK222584 impairs long-term memory. PMID: 19100245 Ref: Insulin analogues display IGF-I-like mitogenic and anti-apoptotic activities in cultured cancer cells. PMID: 19145584 Ref: Astragalus saponins induce apoptosis via an ERK-independent NF-kappaB signaling pathway in the human hepatocellular HepG2 cell line. PMID: 19148542 Ref: Knockin of mutant PIK3CA activates multiple oncogenic pathways. PMID: 19196980 Ref: Netrin-1 increases proliferation and migration of renal proximal tubular epithelial cells via the UNC5B receptor. PMID: 19211685 Ref: Plasma membrane-associated sialidase (NEU3) promotes formation of colonic aberrant crypt foci in azoxymethane-treated transgenic mice. PMID: 19215228 Ref: Acetylcholine-induced activation of M3 muscarinic receptors stimulates robust matrix metalloproteinase gene expression in human colon cancer cells. PMID: 19221016 Ref: Inhibition of macroautophagy by bafilomycin A1 lowers proliferation and induces apoptosis in colon cancer cells. PMID: 19289106 Ref: A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration. PMID: 19305148 Ref: Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells. PMID: 19344998 Ref: Preferential induction of EphB4 over EphB2 and its implication in colorectal cancer progression. PMID: 19366806 Ref: Mechanisms of primary cancer prevention by butyrate and other products formed during gut flora-mediated fermentation of dietary fibre. PMID: 19383551 Ref: A novel anticancer effect of Astragalus saponins: Transcriptional activation of NSAID-activated gene. PMID: 19384947 Ref: Quantitative cell signalling analysis reveals down-regulation of MAPK pathway activation in colorectal cancer. PMID: 19396842 Ref: Tax1 enhances cancer cell proliferation via Ras-Raf-MEK-ERK signaling pathway. PMID: 19472191 Ref: Effects of omega-3 and omega-6 fatty acids on IGF-I receptor signalling in colorectal cancer cells. PMID: 19480565 Ref: 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is up-regulated by flurbiprofen and other non-steroidal anti-inflammatory drugs in human colon cancer HT29 cells. PMID: 19501039 Ref: CUDC-305, a novel synthetic HSP90 inhibitor with unique pharmacologic properties for cancer therapy. PMID: 19509149 Ref: Macrophage inhibitory cytokine-1 (MIC-1) and subsequent urokinase-type plasminogen activator mediate cell death responses by ribotoxic anisomycin in HCT-116 colon cancer cells. PMID: 19540205 Ref: Carbachol induces p70S6K1 activation through an ERK-dependent but Akt-independent pathway in human colonic epithelial cells. PMID: 19615971 Ref: c-Rel is a transcriptional repressor of EPHB2 in colorectal cancer. PMID: 19621336 Ref: [Tissue microarray (TMA) validated progression markers in colorectal cancer using antibody microarrays]. PMID: 19648079 Ref: Up-regulation of Kruppel-like factor 5 in pancreatic cancer is promoted by interleukin-1beta signaling and hypoxia-inducible factor-1alpha. PMID: 19671674 Ref: Novel nitro-oxy derivatives of celecoxib for the regulation of colon cancer cell growth. PMID: 19682443 Ref: Role of prosurvival molecules in the action of lidamycin toward human tumor cells. PMID: 19725468 Ref: Death of ouabain-treated renal epithelial cells: evidence for p38 MAPK-mediated Na (i) (+) /K (i) (+) -independent signaling. PMID: 19784777 Ref: Analysis of candidate target genes for mononucleotide repeat mutation in microsatellite instability-high (MSI-H) endometrial cancer. PMID: 19787250 Ref: Synergistic effects of lovastatin and celecoxib on caveolin-1 and its down-stream signaling molecules: Implications for colon cancer prevention. PMID: 19787257 Ref: RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects. PMID: 19789336 Ref: Salvia fruticosa, Salvia officinalis, and rosmarinic acid induce apoptosis and inhibit proliferation of human colorectal cell lines: the role in MAPK/ERK pathway. PMID: 19838929 Ref: Efficacy of IGFBP7 for treatment of metastatic melanoma and other cancers in mouse models and human cell lines. PMID: 19861408 Ref: Dissociation of EphB2 signaling pathways mediating progenitor cell proliferation and tumor suppression. PMID: 19914164 Ref: Aurora-A overexpression enhances cell-aggregation of Ha-ras transformants through the MEK/ERK signaling pathway. PMID: 20003375 Ref: The protein tyrosine phosphatase receptor type R gene is an early and frequent target of silencing in human colorectal tumorigenesis. PMID: 20015382 Ref: [Combination with SN-38 on human colon cancer LoVo cells]. PMID: 20021826 Ref: Effect of butyrate on the heregulin/ErbB-mediated proliferation of human colorectal cancer cells. PMID: 21475856 |
Ref: CCK2 receptor expression transforms non-tumorigenic human NCM356 colonic epithelial cells into tumor forming cells. PMID: 19697327 Ref: Loss of 15-hydroxyprostaglandin dehydrogenase increases prostaglandin E2 in pancreatic tumors. PMID: 19820419 Ref: Rottlerin induces heme oxygenase-1 (HO-1) up-regulation through reactive oxygen species (ROS) dependent and PKC delta-independent pathway in human colon cancer HT29 cells. PMID: 19833168 Ref: Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling. PMID: 19882352 Ref: The role of Eph receptors and ephrin ligands in colorectal cancer. PMID: 20039322 Ref: Analysis of an alternative human CD133 promoter reveals the implication of Ras/ERK pathway in tumor stem-like hallmarks. PMID: 20167130 Ref: High Erk activity suppresses expression of the cell cycle inhibitor p27Kip1 in colorectal cancer cells. PMID: 20181064 Ref: Hydrogen sulfide induces human colon cancer cell proliferation: role of Akt, ERK and p21. PMID: 20184555 Ref: Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway. PMID: 20198339 Ref: Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study. PMID: 20233436 Ref: Loss of cell-surface receptor EphB2 is important for the growth, migration, and invasiveness of a colon cancer cell line. PMID: 20339854 Ref: (-)-Epigallocatechin gallate inhibits growth and activation of the VEGF/VEGFR axis in human colorectal cancer cells. PMID: 20346928 Ref: (-)-Epigallocatechin-3-gallate inhibits Met signaling, proliferation, and invasiveness in human colon cancer cells. PMID: 20361925 Ref: Induction of the apoptosis inhibitor ARC by Ras in human cancers. PMID: 20392691 Ref: Oncogenic K-ras activates p38 to maintain colorectal cancer cell proliferation during MEK inhibition. PMID: 20413844 Ref: PLX-4032, a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma. PMID: 20496265 Ref: Andrographolide exhibits anti-invasive activity against colon cancer cells via inhibition of MMP2 activity. PMID: 20539971 Ref: A serum-stable branched dimeric anti-VEGF peptide blocks tumor growth via anti-angiogenic activity. PMID: 20543548 Ref: Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91/LRP-1 and NF-kappaB-mediated integrin alphaV expression. PMID: 20558745 Ref: Activating transcription factor 2 (ATF2) controls tolfenamic acid-induced ATF3 expression via MAP kinase pathways. PMID: 20581861 Ref: P21-activated kinase 1 stimulates colon cancer cell growth and migration/invasion via ERK- and AKT-dependent pathways. PMID: 20595063 Ref: Astragalus saponins modulate mTOR and ERK signaling to promote apoptosis through the extrinsic pathway in HT-29 colon cancer cells. PMID: 20664949 Ref: Gamma-tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptors. PMID: 20682650 Ref: Antiproliferative effect of a novel nitro-oxy derivative of celecoxib in human colon cancer cells: role of COX-2 and nitric oxide. PMID: 20682995 Ref: Systematic assessment of protein phenotypes characterizing high-grade tumour budding in mismatch repair-proficient colorectal cancer. PMID: 20716165 Ref: Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer. PMID: 20808308 Ref: P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910. PMID: 20811717 Ref: Sprouty1, a new target of the angiostatic agent 16K prolactin, negatively regulates angiogenesis. PMID: 20813052 Ref: B7h triggering inhibits umbilical vascular endothelial cell adhesiveness to tumor cell lines and polymorphonuclear cells. PMID: 20817864 Ref: Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL. PMID: 20837473 Ref: Phenethyl isothiocyanate inhibited tumor migration and invasion via suppressing multiple signal transduction pathways in human colon cancer HT29 cells. PMID: 20863062 Ref: The induction of S100p expression by the Prostaglandin E(2) (PGE(2))/EP4 receptor signaling pathway in colon cancer cells. PMID: 20890108 Ref: BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation. PMID: 21098728 Ref: Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells. PMID: 21170361 |
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PMID: 27323826 Ref: BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells. PMID: 27351224 Ref: CCR4 promotes metastasis via ERK/NF-kappaB/MMP13 pathway and acts downstream of TNF-alpha in colorectal cancer. PMID: 27356745 Ref: Reactivation of ERK and Akt confers resistance of mutant BRAF colon cancer cells to the HSP90 inhibitor AUY922. PMID: 27391062 Ref: A recellularized human colon model identifies cancer driver genes. PMID: 27398792 Ref: Anticancer Activity of Buttermilk Against SW480 Colon Cancer Cells is Associated with Caspase-Independent Cell Death and Attenuation of Wnt, Akt, and ERK Signaling. PMID: 27472445 Ref: Gossypol induces death receptor-5 through activation of ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL. PMID: 27496964 Ref: Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax. PMID: 27496966 Ref: Enhancer decommissioning by Snail1-induced competitive displacement of TCF7L2 and down-regulation of transcriptional activators results in EPHB2 silencing. PMID: 27504909 Ref: Decreased expression of LncRNA SLC25A25-AS1 promotes proliferation, chemoresistance, and EMT in colorectal cancer cells. PMID: 27553025 Ref: Exploring the N-Terminal Region of C-X-C Motif Chemokine 12 (CXCL12): Identification of Plasma-Stable Cyclic Peptides As Novel, Potent C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonists. PMID: 27571038 Ref: Role of neutral ceramidase in colon cancer. PMID: 27609772 Ref: Current understanding concerning intestinal stem cells. PMID: 27610020 Ref: Gefitinib enhances human colon cancer cells to TRAIL-induced apoptosis of via autophagy- and JNK-mediated death receptors upregulation. PMID: 27629794 Ref: Downregulation of RLIP76 is associated with vincristine resistance in human colorectal cancer HCT-8/VCR cells. PMID: 27633085 Ref: STC2 promotes the epithelial-mesenchymal transition of colorectal cancer cells through AKT-ERK signaling pathways. PMID: 27662663 Ref: The Association of CXC Receptor 4 Mediated Signaling Pathway with Oxaliplatin-Resistant Human Colorectal Cancer Cells. PMID: 27668882 Ref: Combined application of anti-VEGF and anti-EGFR attenuates the growth and angiogenesis of colorectal cancer mainly through suppressing AKT and ERK signaling in mice model. PMID: 27729020 Ref: Impaired coordination between signaling pathways is revealed in human colorectal cancer using single-cell mass cytometry of archival tissue blocks. PMID: 27729552 Ref: Claudin-1 promotes TNF-alpha-induced epithelial-mesenchymal transition and migration in colorectal adenocarcinoma cells. PMID: 27742576 Ref: Acquisition of anticancer drug resistance is partially associated with cancer stemness in human colon cancer cells. PMID: 27748801 Ref: Mutant BRAF Upregulates MCL-1 to Confer Apoptosis Resistance that Is Reversed by MCL-1 Antagonism and Cobimetinib in Colorectal Cancer. PMID: 27765849 Ref: Angiomotin promotes the malignant potential of colon cancer cells by activating the YAP-ERK/PI3K-AKT signaling pathway. PMID: 27779692 Ref: Anti-EGFR antibody sensitizes colorectal cancer stem-like cells to Fluorouracil-induced apoptosis by affecting autophagy. PMID: 27833077 Ref: Prognostic significance of USP33 in advanced colorectal cancer patients: new insights into beta-arrestin-dependent ERK signaling. PMID: 27835898 Ref: Enhanced anti-tumour activity of the combination of the novel MEK inhibitor WX-554 and the novel PI3K inhibitor WX-037. PMID: 27837257 Ref: CTGF enhances resistance to 5-FU-mediating cell apoptosis through FAK/MEK/ERK signal pathway in colorectal cancer. PMID: 27942222 |
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PMID: 27966450 Ref: LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer. PMID: 27999210 Ref: Concomitant inhibition of receptor tyrosine kinases and downstream AKT synergistically inhibited growth of KRAS/BRAF mutant colorectal cancer cells. PMID: 28002807 Ref: Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress. PMID: 28030835 Ref: Prognostic significance of stromal GREM1 expression in colorectal cancer. PMID: 28041973 Ref: Taspine derivative 12k suppressed A549 cell migration through the Wnt/beta-catenin and EphrinB2 signaling pathway. PMID: 28049091 Ref: Loss of periplakin expression is associated with the tumorigenesis of colorectal carcinoma. PMID: 28068625 Ref: SIRT2 mediated antitumor effects of shikonin on metastatic colorectal cancer. PMID: 28088387 Ref: Gab3 is required for human colorectal cancer cell proliferation. PMID: 28115166 Ref: Knockdown of NIK and IKKbeta-Binding Protein (NIBP) Reduces Colorectal Cancer Metastasis through Down-Regulation of the Canonical NF-kappaBeta Signaling Pathway and Suppression of MAPK Signaling Mediated through ERK and JNK. PMID: 28125661 Ref: Biased Signaling by Agonists of Protease Activated Receptor 2. PMID: 28169521 Ref: Targeting TRK family proteins in cancer. PMID: 28174090 Ref: 3'-hydroxy-4'-methoxy-beta-methyl-beta-nitrostyrene inhibits tumorigenesis in colorectal cancer cells through ROS-mediated DNA damage and mitochondrial dysfunction. PMID: 28178649 Ref: microRNA-375 inhibits colorectal cancer cells proliferation by downregulating JAK2/STAT3 and MAP3K8/ERK signaling pathways. PMID: 28186962 Ref: Time-resolved Phosphoproteome Analysis of Paradoxical RAF Activation Reveals Novel Targets of ERK. PMID: 28188228 Ref: Glucose-derived AGEs promote migration and invasion of colorectal cancer by up-regulating Sp1 expression. PMID: 28237576 Ref: In vivo and ex vivo cetuximab sensitivity assay using three-dimensional primary culture system to stratify KRAS mutant colorectal cancer. PMID: 28301591 Ref: Co-targeting of EGFR and autophagy signaling is an emerging treatment strategy in metastatic colorectal cancer. PMID: 28323034 Ref: miR-134: A Human Cancer Suppressor? PMID: 28325280 Ref: Down-regulation of DAB2IP promotes colorectal cancer invasion and metastasis by translocating hnRNPK into nucleus to enhance the transcription of MMP2. PMID: 28335083 Ref: NUBPL, a novel metastasis-related gene, promotes colorectal carcinoma cell motility by inducing epithelial-mesenchymal transition. PMID: 28346728 Ref: Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3beta/beta-catenin pathways. PMID: 28356111 Ref: Assessment of Olea europaea L. fruit extracts: Phytochemical characterization and anticancer pathway investigation. PMID: 28360012 Ref: Rational design, synthesis, and biological evaluation of Pan-Raf inhibitors to overcome resistance. PMID: 28368067 Ref: TGFbeta engages MEK/ERK to differentially regulate benign and malignant pancreas cell function. PMID: 28368414 Ref: Phosphorylation of ETV4 at Ser73 by ERK kinase could block ETV4 ubiquitination degradation in colorectal cancer. PMID: 28373072 Ref: [Inhibitory effect of apatinib on HCT-116 cells and its mechanism]. PMID: 28377354 Ref: RSK activation via ERK modulates human colon cancer cells response to PTHrP. PMID: 28385776 Ref: Resistin causes G1 arrest in colon cancer cells through upregulation of SOCS3. PMID: 28417458 Ref: Identification of NCK1 as a novel downstream effector of STAT3 in colorectal cancer metastasis and angiogenesis. PMID: 28455144 Ref: The CDK4/6 inhibitor palbociclib synergizes with irinotecan to promote colorectal cancer cell death under hypoxia. PMID: 28486050 Ref: Furanodienone induces G0/G1 arrest and causes apoptosis via the ROS/MAPKs-mediated caspase-dependent pathway in human colorectal cancer cells: a study in vitro and in vivo. PMID: 28542135 Ref: Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line. PMID: 28571588 Ref: Continuous or Transient High Level of Glucose Exposure Differentially Increases Coronary Artery Endothelial Cell Proliferation and Human Colon Cancer Cell Proliferation. PMID: 28580314 Ref: Anti-fibrogenic effect of PPAR-gamma agonists in human intestinal myofibroblasts. PMID: 28592228 Ref: RSPO2 suppresses colorectal cancer metastasis by counteracting the Wnt5a/Fzd7-driven noncanonical Wnt pathway. PMID: 28600110 Ref: Autocrine BMP-4 Signaling Is a Therapeutic Target in Colorectal Cancer. PMID: 28611046 Ref: The traditional Chinese medicine Achyranthes bidentata and our de novo conception of its metastatic chemoprevention: from phytochemistry to pharmacology. PMID: 28634392 Ref: Bilateral blockade of MEK- and PI3K-mediated pathways downstream of mutant KRAS as a treatment approach for peritoneal mucinous malignancies. PMID: 28640835 Ref: Clinical responses to ERK inhibition in BRAF(V600E)-mutant colorectal cancer predicted using a computational model. PMID: 28649441 Ref: BRAF-inhibitor Associated MEK Mutations Increase RAF-Dependent and -Independent Enzymatic Activity. PMID: 28655712 Ref: Effect of nonylphenol on the regulation of cell growth in colorectal cancer cells. PMID: 28656208 Ref: Zinc-finger protein 545 is inactivated due to promoter methylation and functions as a tumor suppressor through the Wnt/beta-catenin, PI3K/AKT and MAPK/ERK signaling pathways in colorectal cancer. PMID: 28677721 Ref: A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution. PMID: 28746882 Ref: Berberine inhibits colitis-associated tumorigenesis via suppressing inflammatory responses and the consequent EGFR signaling-involved tumor cell growth. PMID: 28759012 Ref: Tumor microenvironment confers mTOR inhibitor resistance in invasive intestinal adenocarcinoma. PMID: 28759045 Ref: Cancer stem cell-related gene expression as a potential biomarker of response for first-in-class imipridone ONC201 in solid tumors. PMID: 28767654 Ref: Endothelial protein C receptor is overexpressed in colorectal cancer as a result of amplification and hypomethylation of chromosome 20q. PMID: 28770100 Ref: Proliferation and invasion of ovarian cancer cells are suppressed by knockdown of TRIM11. PMID: 28781653 Ref: Antitumor activity of beta-2-himachalen-6-ol in colon cancer is mediated through its inhibition of the PI3K and MAPK pathways. PMID: 28782499 Ref: HspB5 correlates with poor prognosis in colorectal cancer and prompts epithelial-mesenchymal transition through ERK signaling. PMID: 28796798 Ref: An epithelial-to-mesenchymal transition-inducing potential of granulocyte macrophage colony-stimulating factor in colon cancer. PMID: 28811578 Ref: Syndecan-2 cytoplasmic domain up-regulates matrix metalloproteinase-7 expression via the protein kinase Cgamma-mediated FAK/ERK signaling pathway in colon cancer. PMID: 28821612 Ref: Hypoxia-inducible factor 2alpha (HIF-2alpha) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity. PMID: 28848049 Ref: A guanine derivative as a new MEK inhibitor produced by Streptomyces sp. MK63-43F2. PMID: 28874847 Ref: Erratum: Clinical responses to ERK inhibition in BRAF(V600E)-mutant colorectal cancer predicted using a computational model. PMID: 28879057 Ref: PRPF overexpression induces drug resistance through actin cytoskeleton rearrangement and epithelial-mesenchymal transition. PMID: 28915620 Ref: The lauric acid-activated signaling prompts apoptosis in cancer cells. PMID: 28924490 Ref: Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2. PMID: 28931592 Ref: Targeting progastrin enhances radiosensitization of colorectal cancer cells. PMID: 28938581 Ref: Sulforaphane induces p53deficient SW480 cell apoptosis via the ROSMAPK signaling pathway. PMID: 28944886 Ref: Mechanisms of Acquired Resistance to BRAF V600E Inhibition in Colon Cancers Converge on RAF Dimerization and Are Sensitive to Its Inhibition. PMID: 28951457 Ref: SUMOylation of IQGAP1 promotes the development of colorectal cancer. PMID: 28987385 Ref: Downregulation of ZNF278 arrests the cell cycle and decreases the proliferation of colorectal cancer cells via inhibition of the ERK/MAPK pathway. PMID: 29039562 Ref: MicroRNA337 inhibits colorectal cancer progression by directly targeting KRAS and suppressing the AKT and ERK pathways. PMID: 29048669 Ref: RPN2 promotes colorectal cancer cell proliferation through modulating the glycosylation status of EGFR. PMID: 29069815 Ref: miR-422a inhibits cell proliferation in colorectal cancer by targeting AKT1 and MAPK1. PMID: 29118671 Ref: Butyrate suppresses motility of colorectal cancer cells via deactivating Akt/ERK signaling in histone deacetylase dependent manner. PMID: 29233468 Ref: Netrin-1 Prevents Rat Primary Cortical Neurons from Apoptosis via the DCC/ERK Pathway. PMID: 29321724 Ref: Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells. PMID: 29340103 Ref: Chloroform extract of Hedyotis diffusa Willd inhibits viability of human colorectal cancer cells via suppression of AKT and ERK signaling pathways. PMID: 29344237 |
Ref: Therapeutic Potential of Targeting PI3K/AKT Pathway in Treatment of Colorectal Cancer: Rational and Progress. PMID: 28230287 Ref: Targeting RAS signaling pathway as a potential therapeutic target in the treatment of colorectal cancer. PMID: 28262927 Ref: The therapeutic potential of targeting the BRAF mutation in patients with colorectal cancer. PMID: 28407239 Ref: Procaine Inhibits the Proliferation and Migration of Colon Cancer Cells Through Inactivation of the ERK/MAPK/FAK Pathways by Regulation of RhoA. PMID: 28492141 Ref: Long noncoding RNA CCAT1 promotes cell proliferation and metastasis in human medulloblastoma via MAPK pathway. PMID: 28777430 Ref: miR-217-5p induces apoptosis by directly targeting PRKCI, BAG3, ITGAV and MAPK1 in colorectal cancer cells. PMID: 28905214 Ref: Monoclonal Antibodies Directed against Cadherin RGD Exhibit Therapeutic Activity against Melanoma and Colorectal Cancer Metastasis. PMID: 28916526 Ref: Macrophage depletion using clodronate liposomes decreases tumorigenesis and alters gut microbiota in the AOM/DSS mouse model of colon cancer. PMID: 29025731 Ref: Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor. PMID: 29063678 Ref: Oleanolic Acid Inhibits Colorectal Cancer Angiogenesis by Blocking the VEGFR2 Signaling Pathway. PMID: 29065844 Ref: HOXA3 promotes tumor growth of human colon cancer through activating EGFR/Ras/Raf/MEK/ERK signaling pathway. PMID: 29073728 Ref: Rac GTPase activating protein 1 promotes oncogenic progression of epithelial ovarian cancer. PMID: 29095547 Ref: GOLPH3 expression promotes the resistance of HT29 cells to 5fluorouracil by activating multiple signaling pathways. PMID: 29115442 Ref: TNFalpha induces tolerant production of CXC chemokines in colorectal cancer HCT116 cells via A20 inhibition of ERK signaling. PMID: 29175508 Ref: MAPK inhibitors induce serine peptidase inhibitor Kazal type 1 (SPINK1) secretion in BRAF V600E-mutant colorectal adenocarcinoma. PMID: 29193645 Ref: Fibroblast activation protein-alpha in tumor cells promotes colorectal cancer angiogenesis via the Akt and ERK signaling pathways. PMID: 29207091 Ref: Targeting CDK1 and MEK/ERK Overcomes Apoptotic Resistance in BRAF-Mutant Human Colorectal Cancer. PMID: 29233910 Ref: Specificity of Phosphorylation Responses to Mitogen Activated Protein (MAP) Kinase Pathway Inhibitors in Melanoma Cells. PMID: 29255136 Ref: Effect of long non-coding RNA Gas5 on proliferation, migration, invasion and apoptosis of colorectal cancer HT-29 cell line. PMID: 29308053 Ref: Differential Regulation of LET-7 by LIN28B Isoform-Specific Functions. PMID: 29330293 Ref: Caveolin-1 Inhibits Proliferation, Migration, and Invasion of Human Colorectal Cancer Cells by Suppressing Phosphorylation of Epidermal Growth Factor Receptor. PMID: 29339715 Ref: Tunicamycin inhibits colon carcinoma growth and aggressiveness via modulation of the ERK-JNK-mediated AKT/mTOR signaling pathway. PMID: 29344654 Ref: Targeting M3 Muscarinic Receptors for Colon Cancer Therapy. PMID: 29357811 Ref: Formyl peptide receptor 2 mediated chemotherapeutics drug resistance in colon cancer cells. PMID: 29364475 Ref: DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis. PMID: 29379130 Ref: XPNPEP3 is a novel transcriptional target of canonical Wnt/beta-catenin signaling. PMID: 29383790 Ref: p38 activation induces production of miR-146a and miR-31 to repress E-selectin expression and inhibit transendothelial migration of colon cancer cells. PMID: 29402939 Ref: Convergent Therapeutic Strategies to Overcome the Heterogeneity of Acquired Resistance in BRAF(V600E) Colorectal Cancer. PMID: 29431697 Ref: Baicalin induces cellular senescence in human colon cancer cells via upregulation of DEPP and the activation of Ras/Raf/MEK/ERK signaling. PMID: 29440765 Ref: Interaction of the Wnt/beta-catenin and RAS-ERK pathways involving co-stabilization of both beta-catenin and RAS plays important roles in the colorectal tumorigenesis. PMID: 29449169 Ref: TGFBR1*6A is a potential modifier of migration and invasion in colorectal cancer cells. PMID: 29467907 Ref: Andrographolide derivative CX-10 ameliorates dextran sulphate sodium-induced ulcerative colitis in mice: Involvement of NF-kappaB and MAPK signalling pathways. PMID: 29475099 Ref: Impairment of K-Ras signaling networks and increased efficacy of epidermal growth factor receptor inhibitors by a novel synthetic miR-143. PMID: 29498789 Ref: Expressions of IGF-1, ERK, GLUT4, IRS-1 in metabolic syndrome complicated with colorectal cancer and their associations with the clinical characteristics of CRC. PMID: 29504525 Ref: Classifying BRAF alterations in cancer: new rational therapeutic strategies for actionable mutations. PMID: 29540830 Ref: Inhibition of microRNA-21-3p suppresses proliferation as well as invasion and induces apoptosis by targeting RNA-binding protein with multiple splicing through Smad4/extra cellular signal-regulated protein kinase signalling pathway in human colorectal can PMID: 29542167 Ref: Phthalate exposure promotes chemotherapeutic drug resistance in colon cancer cells. PMID: 29568348 Ref: Advances on the BRAF Front in Colorectal Cancer. PMID: 29610287 Ref: Gambogic Acid Efficiently Kills Stem-Like Colorectal Cancer Cells by Upregulating ZFP36 Expression. PMID: 29627822 Ref: Collagen IV-conveyed signals can regulate chemokine production and promote liver metastasis. PMID: 29651051 Ref: Ferric citrate and ferric EDTA but not ferrous sulfate drive amphiregulin-mediated activation of the MAP kinase ERK in gut epithelial cancer cells. PMID: 29682205 Ref: Peroxiredoxin1 promotes cell proliferation, migration and invasion of colorectal cancer via p38MAPK signaling. PMID: 29687844 Ref: MicroRNA125 inhibits RKO colorectal cancer cell growth by targeting VEGF. PMID: 29693153 Ref: Baicalein and baicalin inhibit colon cancer using two distinct fashions of apoptosis and senescence. PMID: 29732005 Ref: Oncogenic KRAS suppresses store-operated Ca(2+) entry and ICRAC through ERK pathway-dependent remodelling of STIM expression in colorectal cancer cell lines. PMID: 29748135 Ref: LIFR promotes tumor angiogenesis by up-regulating IL-8 levels in colorectal cancer. PMID: 29751081 Ref: AZ304, a novel dual BRAF inhibitor, exerts anti-tumour effects in colorectal cancer independently of BRAF genetic status. PMID: 29755114 Ref: Proliferation and invasion of colon cancer cells are suppressed by knockdown of TOP2A. PMID: 29761838 Ref: The protective role of all-transretinoic acid (ATRA) against colorectal cancer development is achieved via increasing miR-3666 expression and decreasing E2F7 expression. PMID: 29772445 Ref: Down-regulating IL-6/GP130 targets improved the anti-tumor effects of 5-fluorouracil in colon cancer. PMID: 29777330 Ref: MicroRNA-485 plays tumour-suppressive roles in colorectal cancer by directly targeting GAB2. PMID: 29781037 Ref: SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo. PMID: 29808006 Ref: AKR1B10 activates diacylglycerol (DAG) second messenger in breast cancer cells. PMID: 29846015 Ref: Quinalizarin Induces Apoptosis through Reactive Oxygen Species (ROS)-Mediated Mitogen-Activated Protein Kinase (MAPK) and Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathways in Colorectal Cancer Cells. PMID: 29860266 Ref: Granulin epithelin precursor promotes colorectal carcinogenesis by activating MARK/ERK pathway. PMID: 29866109 Ref: Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1alpha axis. PMID: 29884183 Ref: 3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1,2,4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation. PMID: 29887940 Ref: Fibroblast growth factor 18 promotes the growth, migration and invasion of MDAMB231 cells. PMID: 29901199 Ref: PTPRS Regulates Colorectal Cancer RAS Pathway Activity by Inactivating Erk and Preventing Its Nuclear Translocation. PMID: 29915291 Ref: CHIP functions as an oncogene by promoting colorectal cancer metastasis via activation of MAPK and AKT signaling and suppression of E-cadherin. PMID: 29921293 Ref: Study on the function and mechanism of long non-coding RNA DMTF1v4 in the occurrence of colon cancer. PMID: 29949153 Ref: Erbin Suppresses KSR1-Mediated RAS/RAF Signaling and Tumorigenesis in Colorectal Cancer. PMID: 29980571 Ref: Nitric oxide-donating aspirin (NO-Aspirin) suppresses lung tumorigenesis in vitro and in vivo and these effects are associated with modulation of the EGFR signaling pathway. PMID: 29982425 Ref: Clinical significance and biological function of WD repeat domain 54 as an oncogene in colorectal cancer. PMID: 29987896 Ref: ERK and p38MAPK combine to improve survival in patients with BRAF mutant colorectal cancer. PMID: 29988110 Ref: Angiogenesis and vasculogenic mimicry are inhibited by 8-Br-cAMP through activation of the cAMP/PKA pathway in colorectal cancer. PMID: 29997437 Ref: Downregulation of PIK3CA via antibody-esiRNA-complexes suppresses human xenograft tumor growth. PMID: 30001368 Ref: Potential therapeutic targets for growth arrest of colorectal cancer cells exposed to PTHrP. PMID: 30009852 Ref: Silencing GOLPH3 gene expression reverses resistance to cisplatin in HT29 colon cancer cells via multiple signaling pathways. PMID: 30015866 Ref: Prognostic Significance of EPHB2 Expression in Colorectal Cancer Progression. PMID: 30016858 Ref: The Zinc Finger Transcription Factor PLAGL2 Enhances Stem Cell Fate and Activates Expression of ASCL2 in Intestinal Epithelial Cells. PMID: 30017821 Ref: Combination of BEZ235 and Metformin Has Synergistic Effect on Cell Viability in Colorectal Cancer Cells. PMID: 30023463 Ref: Expression Profile of LGR5 and Its Prognostic Significance in Colorectal Cancer Progression. PMID: 30036518 Ref: Vemurafenib. PMID: 30069761 Ref: Turmeric extract, with absorbable curcumin, has potent anti-metastatic effect in vitro and in vivo. PMID: 30097113 Ref: Molecular subtypes of colorectal cancer in pre-clinical models show differential response to targeted therapies: Treatment implications beyond KRAS mutations. PMID: 30118499 Ref: Development of small-molecule therapeutics and strategies for targeting RAF kinase in BRAF-mutant colorectal cancer. PMID: 30122982 Ref: MiRNA-206 suppresses PGE2-induced colorectal cancer cell proliferation, migration, and invasion by targetting TM4SF1. PMID: 30135139 Ref: miR-372 and miR-373 enhance the stemness of colorectal cancer cells by repressing differentiation signaling pathways. PMID: 30171794 Ref: MEK inhibitors induce apoptosis via FoxO3a-dependent PUMA induction in colorectal cancer cells. PMID: 30190455 Ref: NCOA4-RET fusion in colorectal cancer: Therapeutic challenge using patient-derived tumor cell lines. PMID: 30210625 Ref: HSCs-derived COMP drives hepatocellular carcinoma progression by activating MEK/ERK and PI3K/AKT signaling pathways. PMID: 30231922 Ref: PMA treated THP-1-derived-IL-6 promotes EMT of SW48 through STAT3/ERK-dependent activation of Wnt/beta-catenin signaling pathway. PMID: 30243096 Ref: CCL19 suppresses angiogenesis through promoting miR-206 and inhibiting Met/ERK/Elk-1/HIF-1alpha/VEGF-A pathway in colorectal cancer. PMID: 30250188 Ref: MiR-1260b inhibitor enhances the chemosensitivity of colorectal cancer cells to fluorouracil by targeting PDCD4/IGF1. PMID: 30250581 Ref: Upregulation of long noncoding RNA CCAT1-L promotes epithelial-mesenchymal transition in gastric adenocarcinoma. PMID: 30254457 Ref: HMGB1 promotes ERK-mediated mitochondrial Drp1 phosphorylation for chemoresistance through RAGE in colorectal cancer. PMID: 30258050 Ref: Reply to comment of "ERK and p38MAPK combine to improve survival in patients with BRAF mutant colorectal cancer". PMID: 30297771 Ref: Comment on "ERK and p38MAPK combine to improve survival in patients with BRAF mutant colorectal cancer". PMID: 30297772 Ref: ERBB2 and KRAS Alterations Mediate Response to EGFR Inhibitors in Early Stage Gallbladder Cancer. PMID: 30304546 Ref: ZC3H13 suppresses colorectal cancer proliferation and invasion via inactivating Ras-ERK signaling. PMID: 30311220 Ref: Antisense Oligonucleotides against miR-21 Inhibit the Growth and Metastasis of Colorectal Carcinoma via the DUSP8 Pathway. PMID: 30317164 Ref: Apoptotic effect of enterodiol, the final metabolite of edible lignans, in colorectal cancer cells. PMID: 30357838 Ref: alpha-Hederin Arrests Cell Cycle at G2/M Checkpoint and Promotes Mitochondrial Apoptosis by Blocking Nuclear Factor-kappaB Signaling in Colon Cancer Cells. PMID: 30363706 Ref: PEA15 promotes liver metastasis of colorectal cancer by upregulating the ERK/MAPK signaling pathway. PMID: 30365128 Ref: Up-regulation of microRNA-497 inhibits the proliferation, migration and invasion but increases the apoptosis of multiple myeloma cells through the MAPK/ERK signaling pathway by targeting Raf-1. PMID: 30382763 Ref: The small organic molecule C19 binds and strengthens the KRAS4b-PDEdelta complex and inhibits growth of colorectal cancer cells in vitro and in vivo. PMID: 30382908 |