Primary Site >> Colorectal Cancer

Gene >> ELAVL1

Journal: EMBO J. 2000 May 15;19(10):2340-50.
Title: HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation.
Author: Wang, W|Caldwell, M C|Lin, S|Furneaux, H|Gorospe, M
PMID: 10811625
Journal: Mol Cell Biol. 2000 Feb;20(3):760-9.
Title: HuR regulates p21 mRNA stabilization by UV light.
Author: Wang, W|Furneaux, H|Cheng, H|Caldwell, M C|Hutter, D|Liu, Y|Holbrook, N|Gorospe, M
PMID: 10629032
Journal: J Clin Invest. 2001 Dec;108(11):1657-65.
Title: Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells.
Author: Dixon, D A|Tolley, N D|King, P H|Nabors, L B|McIntyre, T M|Zimmerman, G A|Prescott, S M
PMID: 11733561
Journal: Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8354-9.
Title: RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation.
Author: Mazan-Mamczarz, Krystyna|Galban, Stefanie|Lopez de Silanes, Isabel|Martindale, Jennifer L|Atasoy, Ulus|Keene, Jack D|Gorospe, Myriam
PMID: 12821781
Journal: J Biol Chem. 2003 Nov 21;278(47):47119-28.
Title: RNAi-mediated HuR depletion leads to the inhibition of muscle cell differentiation.
Author: van der Giessen, Kate|Di-Marco, Sergio|Clair, Eveline|Gallouzi, Imed Eddine
PMID: 12944397
Journal: Oncogene. 2003 Oct 16;22(46):7146-54.
Title: Role of the RNA-binding protein HuR in colon carcinogenesis.
Author: Lopez de Silanes, Isabel|Fan, Jinshui|Yang, Xiaoling|Zonderman, Alan B|Potapova, Olga|Pizer, Ellen S|Gorospe, Myriam
PMID: 14562043
Journal: Gene Expr. 2004;12(1):49-59.
Title: Global analysis of HuR-regulated gene expression in colon cancer systems of reducing complexity.
Author: Lopez de Silanes, Isabel|Fan, Jinshui|Galban, Craig J|Spencer, Richard G|Becker, Kevin G|Gorospe, Myriam
PMID: 15473260
Journal: J Biol Chem. 2005 Aug 5;280(31):28230-40. Epub 2005 Jun 9.
Title: Delayed mechanism for induction of gamma-glutamylcysteine synthetase heavy subunit mRNA stability by oxidative stress involving p38 mitogen-activated protein kinase signaling.
Author: Song, Im-Sook|Tatebe, Shigeru|Dai, Wenping|Kuo, M Tien
PMID: 15946948
Journal: J Steroid Biochem Mol Biol. 2005 Nov;97(3):219-29.
Title: The c-Yes 3'-UTR contains adenine/uridine-rich elements that bind AUF1 and HuR involved in mRNA decay in breast cancer cells.
Author: Sommer, Stephanie|Cui, Yukun|Brewer, Gary|Fuqua, Suzanne A W
PMID: 16289864
Journal: Mod Pathol. 2006 Sep;19(9):1261-9. Epub 2006 Jun 23.
Title: Expression of the ELAV-like protein HuR in human colon cancer: association with tumor stage and cyclooxygenase-2.
Author: Denkert, Carsten|Koch, Ines|von Keyserlingk, Nora|Noske, Aurelia|Niesporek, Silvia|Dietel, Manfred|Weichert, Wilko
PMID: 16799479
Journal: Nucleic Acids Res. 2006;34(19):5705-14.
Title: Beta-Catenin stabilizes cyclooxygenase-2 mRNA by interacting with AU-rich elements of 3'-UTR.
Author: Lee, Hee Kyu|Jeong, Sunjoo
PMID: 17040897
Journal: Am J Physiol Gastrointest Liver Physiol. 2007 Oct;293(4):G719-28. Epub 2007 Jul
Title: HETEs enhance IL-1-mediated COX-2 expression via augmentation of message stability in human colonic myofibroblasts.
Author: Di Mari, J F|Saada, J I|Mifflin, R C|Valentich, J D|Powell, D W
PMID: 17640979
Journal: Cancer Biol Ther. 2008 Mar;7(3):424-7. Epub 2007 Dec 13.
Title: Increased expression of cytoplasmic HuR in familial adenomatous polyposis.
Author: Brosens, Lodewijk A A|Keller, Josbert J|Pohjola, Leena|Haglund, Caj|Morsink, Folkert H|Iacobuzio-Donahue, Christine|Goggins, Michael|Giardiello, Francis M|Ristimaki, Ari|Offerhaus, G Johan A
PMID: 18094611
Journal: Gastroenterology. 2009 May;136(5):1669-79.
Title: The mRNA binding proteins HuR and tristetraprolin regulate cyclooxygenase 2 expression during colon carcinogenesis.
Author: Young, Lisa E|Sanduja, Sandhya|Bemis-Standoli, Kristi|Pena, Edsel A|Price, Robert L|Dixon, Dan A
PMID: 19208339
Journal: Cancer Res Treat. 2009 Jun;41(2):87-92.
Title: Cytoplasmic expression of HuR is related to cyclooxygenase-2 expression in colon cancer.
Author: Lim, Sung-Jig|Lee, Suk-Hwan|Joo, Sun Hyung|Song, Jeong Yoon|Choi, Sung Il
PMID: 19707506
Journal: JOP. 2009 Jul 6;10(4):357-60.
Title: Pharmacogenetics in pancreatic cancer. Highlights from the 45th ASCO annual meeting. Orlando, FL, USA. May 29-June 2, 2009.
Author: Strimpakos, Alexios S|Syrigos, Kostas N|Saif, Muhammad Wasif
PMID: 19581734
Journal: Ann Surg Oncol. 2009 Jan;16(1):200-7.
Title: Tissue microarray analysis of 560 patients with colorectal adenocarcinoma: high expression of HuR predicts poor survival.
Author: Yoo, Peter S|Sullivan, Catherine A W|Kiang, Sharon|Gao, Wenli|Uchio, Edward M|Chung, Gina G|Cha, Charles H
PMID: 19009247
Journal: J Biol Chem. 2010 Jun 25;285(26):20015-21.
Title: Novel function and intracellular localization of methionine adenosyltransferase 2beta splicing variants.
Author: Xia, Meng|Chen, Yongheng|Wang, Ling-Chi|Zandi, Ebrahim|Yang, Heping|Bemanian, Sean|Martinez-Chantar, M Luz|Mato, Jose M|Lu, Shelly C
PMID: 20421296
Journal: Carcinogenesis. 2011 May;32(5):676-85.
Title: High-constitutive HuR phosphorylation at Ser 318 by PKC{delta} propagates tumor relevant functions in colon carcinoma cells.
Author: Doller, Anke|Winkler, Christine|Azrilian, Irina|Schulz, Sebastian|Hartmann, Sylvia|Pfeilschifter, Josef|Eberhardt, Wolfgang
PMID: 21310943
Journal: EMBO J. 2011 Mar 16;30(6):1040-53.
Title: Global dissociation of HuR-mRNA complexes promotes cell survival after ionizing radiation.
Author: Masuda, Kiyoshi|Abdelmohsen, Kotb|Kim, Mihee M|Srikantan, Subramanya|Lee, Eun Kyung|Tominaga, Kumiko|Selimyan, Roza|Martindale, Jennifer L|Yang, Xiaoling|Lehrmann, Elin|Zhang, Yongqing|Becker, Kevin G|Wang, Jian-Ying|Kim, Hyeon Ho|Gorospe, Myriam
PMID: 21317874
Journal: Nat Rev Gastroenterol Hepatol. 2011 Dec 13;9(1):4.
Title: Cancer: Mdm2-regulated stabilization of HuR by neddylation in HCC and colon cancer--a possible target for therapy.
Author: McLarnon, Andy
PMID: 22158377
Journal: Mol Cancer Res. 2012 Jan;10(1):167-80.
Title: The mRNA stability factor HuR inhibits microRNA-16 targeting of COX-2.
Author: Young, Lisa E|Moore, Ashleigh E|Sokol, Lena|Meisner-Kober, Nicole|Dixon, Dan A
PMID: 22049153
Journal: Hepatology. 2012 Apr;55(4):1237-48.
Title: Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation.
Author: Embade, Nieves|Fernandez-Ramos, David|Varela-Rey, Marta|Beraza, Naiara|Sini, Marcella|Gutierrez de Juan, Virginia|Woodhoo, Ashwin|Martinez-Lopez, Nuria|Rodriguez-Iruretagoyena, Begona|Bustamante, Francisco Javier|de la Hoz, Ana Belen|Carracedo, Arkaitz|Xi
PMID: 22095636
Journal: Front Physiol. 2012 Mar 30;3:68.
Title: MicroRNA Regulation of SIRT1.
Author: Yamakuchi, Munekazu
PMID: 22479251
Journal: J Biol Chem. 2012 Jun 8;287(24):19841-55.
Title: Two in-and-out modulation strategies for endoplasmic reticulum stress-linked gene expression of pro-apoptotic macrophage-inhibitory cytokine 1.
Author: Park, Seong-Hwan|Choi, Hye Jin|Yang, Hyun|Do, Kee Hun|Kim, Juil|Kim, Hyun-Hong|Lee, Heejeong|Oh, Chang Gyu|Lee, Dong Won|Moon, Yuseok
PMID: 22511768
Journal: Nucleic Acids Res. 2012 Aug;40(14):6863-72.
Title: beta-Catenin recognizes a specific RNA motif in the cyclooxygenase-2 mRNA 3'-UTR and interacts with HuR in colon cancer cells.
Author: Kim, Inae|Kwak, Hoyun|Lee, Hee Kyu|Hyun, Soonsil|Jeong, Sunjoo
PMID: 22544606
Journal: Biofactors. 2013 Mar-Apr;39(2):221-32.
Title: Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis.
Author: Murakami, Akira|Furukawa, Ikuyo|Miyamoto, Shingo|Tanaka, Takuji|Ohigashi, Hajime
PMID: 23233214
Journal: Carcinogenesis. 2013 Nov;34(11):2610-21.
Title: Trichostatin-A modulates claudin-1 mRNA stability through the modulation of Hu antigen R and tristetraprolin in colon cancer cells.
Author: Sharma, Ashok|Bhat, Ajaz A|Krishnan, Moorthy|Singh, Amar B|Dhawan, Punita
PMID: 23880304
Journal: Oncol Rep. 2014 Jan;31(1):342-50.
Title: Proteomic analysis reveals that MAEL, a component of nuage, interacts with stress granule proteins in cancer cells.
Author: Yuan, Liqin|Xiao, Yuzhong|Zhou, Qiuzhi|Yuan, Dongmei|Wu, Baiping|Chen, Gannong|Zhou, Jianlin
PMID: 24189637
Journal: Asian Pac J Cancer Prev. 2014;15(7):3145-9.
Title: Pathway and network analysis in glioma with the partial least squares method.
Author: Gu, Wen-Tao|Gu, Shi-Xin|Shou, Jia-Jun
PMID: 24815461
Journal: Mol Cell Biol. 2014 Aug;34(15):2857-73.
Title: HuR regulates alternative splicing of the TRA2beta gene in human colon cancer cells under oxidative stress.
Author: Akaike, Yoko|Masuda, Kiyoshi|Kuwano, Yuki|Nishida, Kensei|Kajita, Keisuke|Kurokawa, Ken|Satake, Yuzuru|Shoda, Katsutoshi|Imoto, Issei|Rokutan, Kazuhito
PMID: 24865968
Journal: Cell Death Dis. 2014 Jul 10;5:e1321.
Title: Attenuation of the ELAV1-like protein HuR sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by increasing the translation of caspase-2L.
Author: Winkler, C|Doller, A|Imre, G|Badawi, A|Schmid, T|Schulz, S|Steinmeyer, N|Pfeilschifter, J|Rajalingam, K|Eberhardt, W
PMID: 25010987
Journal: Cancer Res. 2014 Sep 15;74(18):5322-35.
Title: Intestinal epithelial HuR modulates distinct pathways of proliferation and apoptosis and attenuates small intestinal and colonic tumor development.
Author: Giammanco, Antonina|Blanc, Valerie|Montenegro, Grace|Klos, Coen|Xie, Yan|Kennedy, Susan|Luo, Jianyang|Chang, Sung-Hee|Hla, Timothy|Nalbantoglu, Ilke|Dharmarajan, Sekhar|Davidson, Nicholas O
PMID: 25085247
Journal: J Natl Cancer Inst. 2015 Feb 6;107(4). pii: dju505.
Title: Role of MYC-regulated long noncoding RNAs in cell cycle regulation and tumorigenesis.
Author: Kim, Taewan|Jeon, Young-Jun|Cui, Ri|Lee, Ji-Hoon|Peng, Yong|Kim, Sung-Hak|Tili, Esmerina|Alder, Hansjuerg|Croce, Carlo M
PMID: 25663692
Journal: Pancreatology. 2015 Jul;15(4 Suppl):S49-54.
Title: NEDDylation in liver cancer: The regulation of the RNA binding protein Hu antigen R.
Author: Fernandez-Ramos, David|Martinez-Chantar, Maria L
PMID: 25841271
Journal: Exp Cell Res. 2015 Nov 1;338(2):222-31.
Title: Exploiting a novel miR-519c-HuR-ABCG2 regulatory pathway to overcome chemoresistance in colorectal cancer.
Author: To, Kenneth K W|Leung, W W|Ng, Simon S M
PMID: 26386386
Journal: Front Genet. 2015 Sep 15;6:288.
Title: Exome sequencing of a colorectal cancer family reveals shared mutation pattern and predisposition circuitry along tumor pathways.
Author: Suleiman, Suleiman H|Koko, Mahmoud E|Nasir, Wafaa H|Elfateh, Ommnyiah|Elgizouli, Ubai K|Abdallah, Mohammed O E|Alfarouk, Khalid O|Hussain, Ayman|Faisal, Shima|Ibrahim, Fathelrahamn M A|Romano, Maurizio|Sultan, Ali|Banks, Lawrence|Newport, Melanie|Baralle,
PMID: 26442106
Journal: J Biol Chem. 2016 Dec 9;291(50):25823-25836.
Title: Autotaxin Expression Is Regulated at the Post-transcriptional Level by the RNA-binding Proteins HuR and AUF1.
Author: Sun, Shuhong|Zhang, Xiaotian|Lyu, Lin|Li, Xixi|Yao, Siliang|Zhang, Junjie
PMID: 27784781
Journal: Oncotarget. 2016 Nov 8;7(45):74043-74058.
Title: Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis.
Author: Blanco, Fernando F|Preet, Ranjan|Aguado, Andrea|Vishwakarma, Vikalp|Stevens, Laura E|Vyas, Alok|Padhye, Subhash|Xu, Liang|Weir, Scott J|Anant, Shrikant|Meisner-Kober, Nicole|Brody, Jonathan R|Dixon, Dan A
PMID: 27677075
Journal: Eur J Surg Oncol. 2016 Nov;42(11):1654-1659.
Title: Lower muscle density is associated with major postoperative complications in older patients after surgery for colorectal cancer.
Author: Margadant, C C|Bruns, E R J|Sloothaak, D A M|van Duijvendijk, P|van Raamt, A F|van der Zaag, H J|Buskens, C J|van Munster, B C|van der Zaag, E S
PMID: 27554247
Journal: Cancer Lett. 2017 May 1;393:103-112.
Title: Silencing of the mRNA-binding protein HuR increases the sensitivity of colorectal cancer cells to ionizing radiation through upregulation of caspase-2.
Author: Badawi, Amel|Hehlgans, Stephanie|Pfeilschifter, Josef|Rodel, Franz|Eberhardt, Wolfgang
PMID: 28219770
Journal: Mol Cancer Res. 2017 Jun;15(6):696-707.
Title: CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype.
Author: Lal, Shruti|Cheung, Edwin C|Zarei, Mahsa|Preet, Ranjan|Chand, Saswati N|Mambelli-Lisboa, Nicole C|Romeo, Carmella|Stout, Matthew C|Londin, Eric|Goetz, Austin|Lowder, Cinthya Y|Nevler, Avinoam|Yeo, Charles J|Campbell, Paul M|Winter, Jordan M|Dixon, Dan A|B
PMID: 28242812
Journal: Cancer Res. 2017 May 1;77(9):2424-2438.
Title: HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis.
Author: Lang, Michaela|Berry, David|Passecker, Katharina|Mesteri, Ildiko|Bhuju, Sabin|Ebner, Florian|Sedlyarov, Vitaly|Evstatiev, Rayko|Dammann, Kyle|Loy, Alexander|Kuzyk, Orest|Kovarik, Pavel|Khare, Vineeta|Beibel, Martin|Roma, Guglielmo|Meisner-Kober, Nicole|Ga
PMID: 28428272
Journal: PLoS One. 2017 Oct 2;12(10):e0185625.
Title: Modulation of the mRNA-binding protein HuR as a novel reversal mechanism of epirubicin-triggered multidrug resistance in colorectal cancer cells.
Author: Lin, Guan-Liang|Ting, Huei-Ju|Tseng, Ta-Chien|Juang, Vivian|Lo, Yu-Li
PMID: 28968471
Journal: Mol Cancer. 2018 Jan 19;17(1):11.
Title: The Jun/miR-22/HuR regulatory axis contributes to tumourigenesis in colorectal cancer.
Author: Liu, Yanqing|Chen, Xiaorui|Cheng, Rongjie|Yang, Fei|Yu, Mengchao|Wang, Chen|Cui, Shufang|Hong, Yeting|Liang, Hongwei|Liu, Minghui|Zhao, Chihao|Ding, Meng|Sun, Wu|Liu, Zhijian|Sun, Feng|Zhang, Chenyu|Zhou, Zhen|Jiang, Xiaohong|Chen, Xi
PMID: 29351796
Journal: Oncol Res. 2018 Jan 31.
Title: Up-regulation of miR-324-5p inhibits proliferation and invasion of colorectal cancer cells by targeting ELAVL1.
Author: Gu, Chijiang|Zhang, Mingyuan|Sun, Weiliang|Dong, Changzheng
PMID: 29386086
Journal: Cancer Lett. 2018 May 1;421:145-151.
Title: MiR-155-5p controls colon cancer cell migration via post-transcriptional regulation of Human Antigen R (HuR).
Author: Al-Haidari, Amr|Algaber, Anwar|Madhi, Raed|Syk, Ingvar|Thorlacius, Henrik
PMID: 29471005
Journal: Int J Oncol. 2018 Mar 6.
Title: Studying the mechanism of PLAGL2 overexpression and its carcinogenic characteristics based on 3'-untranslated region in colorectal cancer.
Author: Su, Chen|Li, Daojiang|Li, Nanpeng|Du, Yuheng|Yang, Chunxing|Bai, Yang|Lin, Changwei|Li, Xiaorong|Zhang, Yi
PMID: 29512763
Journal: Oncotarget. 2018 Apr 6;9(26):18367-18385.
Title: Inhibition of IRES-dependent translation of caspase-2 by HuR confers chemotherapeutic drug resistance in colon carcinoma cells.
Author: Badawi, Amel|Biyanee, Abhiruchi|Nasrullah, Usman|Winslow, Sofia|Schmid, Tobias|Pfeilschifter, Josef|Eberhardt, Wolfgang
PMID: 29719611
Journal: Nucleic Acids Res. 2018 Jun 20;46(11):5809-5821.
Title: Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancer.
Author: Lan, Yang|Xiao, Xuewei|He, Zhengchi|Luo, Yu|Wu, Chuanfang|Li, Ling|Song, Xu
PMID: 29931370
Journal: J Cell Physiol. 2018 Oct 14.
Title: Long noncoding RNA gastric cancer-associated transcript 3 plays oncogenic roles in glioma through sponging miR-3127-5p.
Author: Pan, Bailin|Zhao, Ming|Xu, Longbiao
PMID: 30317610
Journal: Cell Death Differ. 2018 Oct 19. pii: 10.1038/s41418-018-0220-6.
Title: Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes.
Author: Chen, Yajun|Yang, Feng|Fang, Erhu|Xiao, Wenjing|Mei, Hong|Li, Huanhuan|Li, Dan|Song, Huajie|Wang, Jianqun|Hong, Mei|Wang, Xiaojing|Huang, Kai|Zheng, Liduan|Tong, Qiangsong
PMID: 30341421