Literatures

Primary Site >> Colorectal Cancer

Gene >> EIF4E

1.
Journal:	Anticancer Res. 2000 May-Jun;20(3A):1343-51.
Title:	Translational control of malignancy: the mRNA cap-binding protein, eIF-4E, as a central regulator of tumor formation, growth, invasion and metastasis.
Author:	Zimmer, S G\|DeBenedetti, A\|Graff, J R
PMID:	10928042

2.
Journal:	Int J Biochem Cell Biol. 2000 Jun;32(6):633-42.
Title:	4E binding protein 1 expression is inversely correlated to the progression of gastrointestinal cancers.
Author:	Martin, M E\|Perez, M I\|Redondo, C\|Alvarez, M I\|Salinas, M\|Fando, J L
PMID:	10785360

3.
Journal:	Cell Commun Adhes. 2001;8(2):87-97.
Title:	Ectopic expression of eIF-4E in human colon cancer cells promotes the stimulation of adhesion molecules by transforming growth factorbeta.
Author:	Rajagopal, S\|Chakrabarty, S
PMID:	11771728

4.
Journal:	Cancer Epidemiol Biomarkers Prev. 2001 Jun;10(6):663-6.
Title:	Expression of the translation initiation factor eIF4E in the polyp-cancer sequence in the colon.
Author:	Berkel, H J\|Turbat-Herrera, E A\|Shi, R\|de Benedetti, A
PMID:	11401917

5.
Journal:	J Biol Chem. 2002 Apr 19;277(16):13907-17. Epub 2002 Feb 14.
Title:	4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin.
Author:	Dilling, Michael B\|Germain, Glen S\|Dudkin, Lorina\|Jayaraman, Arun L\|Zhang, Xiongwen\|Harwood, Franklin C\|Houghton, Peter J
PMID:	11847216

6.
Journal:	J Biol Chem. 2002 Aug 2;277(31):28127-34. Epub 2002 May 8.
Title:	Predominant nuclear localization of mammalian target of rapamycin in normal and malignant cells in culture.
Author:	Zhang, Xiongwen\|Shu, Lili\|Hosoi, Hajime\|Murti, K Gopal\|Houghton, Peter J
PMID:	12000755

7.
Journal:	J Biol Chem. 2002 Oct 11;277(41):38205-11.
Title:	Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells.
Author:	Fukuda, Ryo\|Hirota, Kiichi\|Fan, Fan\|Jung, Young Do\|Ellis, Lee M\|Semenza, Gregg L
PMID:	12149254

8.
Journal:	World J Gastroenterol. 2003 Aug;9(8):1707-12.
Title:	Contribution of eIF-4E inhibition to the expression and activity of heparanase in human colon adenocarcinoma cell line: LS-174T.
Author:	Yang, Yu-Jie\|Zhang, Ya-Li\|Li, Xu\|Dan, Han-Lei\|Lai, Zhuo-Sheng\|Wang, Ji-De\|Wang, Qun-Ying\|Cui, Hai-Hong\|Sun, Yong\|Wang, Ya-Dong
PMID:	12918105

9.
Journal:	Ai Zheng. 2003 Oct;22(10):1023-9.
Title:	[Role of eukaryotic initiation factor-4E (eIF-4E) in regulation of expression of NF-kappaB and its subsequent influence on transcription and activity of heparanase in human colon adenocarcinoma cell line].
Author:	Yang, Yu-Jie\|Zhang, Ya-Li\|Wang, Ji-De\|Lai, Zhuo-Sheng\|Wang, Qun-Ying\|Cui, Hai-Hong
PMID:	14558943

10.
Journal:	Carcinogenesis. 2006 Jul;27(7):1323-33. Epub 2006 Mar 10.
Title:	Global alterations in mRNA polysomal recruitment in a cell model of colorectal cancer progression to metastasis.
Author:	Provenzani, Alessandro\|Fronza, Raffaele\|Loreni, Fabrizio\|Pascale, Alessia\|Amadio, Marialaura\|Quattrone, Alessandro
PMID:	16531451

11.
Journal:	Cancer Res. 2007 Apr 15;67(8):3569-73.
Title:	Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1.
Author:	Hu, Jing\|Straub, Jonathan\|Xiao, Dong\|Singh, Shivendra V\|Yang, Hsin-Sheng\|Sonenberg, Nahum\|Vatsyayan, Jaya
PMID:	17440067

12.
Journal:	Oncol Rep. 2008 Jan;19(1):257-62.
Title:	Validation of biomarkers associated with 5-fluorouracil and thymidylate synthase in colorectal cancer.
Author:	Xi, Yaguang\|Formentini, Andrea\|Nakajima, Go\|Kornmann, Marko\|Ju, Jingfang
PMID:	18097604

13.
Journal:	J Clin Oncol. 2008 Apr 1;26(10):1603-10.
Title:	Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors.
Author:	Tabernero, Josep\|Rojo, Federico\|Calvo, Emiliano\|Burris, Howard\|Judson, Ian\|Hazell, Katharine\|Martinelli, Erika\|Ramon y Cajal, Santiago\|Jones, Suzanne\|Vidal, Laura\|Shand, Nicholas\|Macarulla, Teresa\|Ramos, Francisco Javier\|Dimitrijevic, Sasa\|Zoellner, Ulrik
PMID:	18332469

14.
Journal:	Curr Pharm Biotechnol. 2008 Dec;9(6):510-5.
Title:	The database dbEST correctly predicts gene expression in colon cancer patients.
Author:	Radeva, M\|Hofmann, T\|Altenberg, B\|Mothes, H\|Richter, K K\|Pool-Zobel, B\|Greulich, K O
PMID:	19075689

15.
Journal:	Cancer Biol Ther. 2009 Aug;8(15):1463-9. Epub 2009 Aug 8.
Title:	Phosphorylated eukaryotic translation initiation factor 4 (eIF4E) is elevated in human cancer tissues.
Author:	Fan, Songqing\|Ramalingam, Suresh S\|Kauh, John\|Xu, Zhiheng\|Khuri, Fadlo R\|Sun, Shi-Yong
PMID:	19483468

16.
Journal:	Mol Cancer. 2010 May 6;9:100.
Title:	Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci.
Author:	Berg, Marianne\|Agesen, Trude H\|Thiis-Evensen, Espen\|Merok, Marianne A\|Teixeira, Manuel R\|Vatn, Morten H\|Nesbakken, Arild\|Skotheim, Rolf I\|Lothe, Ragnhild A
PMID:	20459617

17.
Journal:	J Exp Clin Cancer Res. 2010 Nov 22;29:151.
Title:	miRNA-145 inhibits non-small cell lung cancer cell proliferation by targeting c-Myc.
Author:	Chen, Zhe\|Zeng, Huazong\|Guo, Yong\|Liu, Pei\|Pan, Hui\|Deng, Anmei\|Hu, Jian
PMID:	21092188

18.
Journal:	Mol Cancer Ther. 2010 Dec;9(12):3158-63.
Title:	Modulation of 4E-BP1 function as a critical determinant of enzastaurin-induced apoptosis.
Author:	Dumstorf, Chad A\|Konicek, Bruce W\|McNulty, Ann M\|Parsons, Stephen H\|Furic, Luc\|Sonenberg, Nahum\|Graff, Jeremy R
PMID:	20971826

19.
Journal:	Carcinogenesis. 2011 Mar;32(3):318-26.
Title:	Associations between genetic variation in RUNX1, RUNX2, RUNX3, MAPK1 and eIF4E and riskof colon and rectal cancer: additional support for a TGF-beta-signaling pathway.
Author:	Slattery, Martha L\|Lundgreen, Abbie\|Herrick, Jennifer S\|Caan, Bette J\|Potter, John D\|Wolff, Roger K
PMID:	21088106

20.
Journal:	Cancer Res. 2011 Mar 1;71(5):1849-57.
Title:	Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases.
Author:	Konicek, Bruce W\|Stephens, Jennifer R\|McNulty, Ann M\|Robichaud, Nathaniel\|Peery, Robert B\|Dumstorf, Chad A\|Dowless, Michele S\|Iversen, Philip W\|Parsons, Stephen\|Ellis, Karen E\|McCann, Denis J\|Pelletier, Jerry\|Furic, Luc\|Yingling, Jonathan M\|Stancato, Loui
PMID:	21233335

21.
Journal:	Cancer. 2011 Sep 15;117(18):4175-83.
Title:	Genetic variation in the transforming growth factor-beta signaling pathway and survival after diagnosis with colon and rectal cancer.
Author:	Slattery, Martha L\|Lundgreen, Abbie\|Herrick, Jennifer S\|Wolff, Roger K\|Caan, Bette J
PMID:	21365634

22.
Journal:	Int J Oncol. 2013 Jul;43(1):141-50.
Title:	Dual inhibition of EGFR and c-Met kinase activation by MJ-56 reduces metastasis of HT29 human colorectal cancer cells.
Author:	Chen, Hui-Jye\|Jiang, Yi-Lin\|Lin, Chung-Ming\|Tsai, Shih-Chang\|Peng, Shu-Fen\|Fushiya, Shinji\|Hour, Mann-Jen\|Yang, Jai-Sing
PMID:	23677180

23.
Journal:	Eur J Cancer. 2013 Oct;49(15):3311-9.
Title:	Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA-21 mediated programmed cell death 4 (PDCD4) expression.
Author:	Saxena, Ashish\|Shoeb, Mohammad\|Ramana, Kota V\|Srivastava, Satish K
PMID:	23827854

24.
Journal:	Mol Cancer Ther. 2013 Nov;12(11):2483-93.
Title:	The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells.
Author:	Sreevalsan, Sandeep\|Safe, Stephen
PMID:	24030632

25.
Journal:	Cell Death Dis. 2013 Oct 10;4:e851.
Title:	Translational control in the stress adaptive response of cancer cells: a novel role for the heat shock protein TRAP1.
Author:	Matassa, D S\|Amoroso, M R\|Agliarulo, I\|Maddalena, F\|Sisinni, L\|Paladino, S\|Romano, S\|Romano, M F\|Sagar, V\|Loreni, F\|Landriscina, M\|Esposito, F
PMID:	24113185

26.
Journal:	Cancer Cell Microenviron. 2014;1(5).
Title:	New insights into 4E-BP1-regulated translation in cancer progression and metastasis.
Author:	Wang, Jun\|Ye, Qing\|She, Qing-Bai
PMID:	26005705

27.
Journal:	PLoS One. 2014 Jun 11;9(6):e99254.
Title:	Alpha-2-glycoprotein 1(AZGP1) regulates biological behaviors of LoVo cells by down-regulating mTOR signaling pathway and endogenous fatty acid synthesis.
Author:	Chang, Ligong\|Tian, Xiaoqiang\|Lu, Yinghui\|Jia, Min\|Wu, Peng\|Huang, Peilin
PMID:	24918753

28.
Journal:	Cell Rep. 2014 Apr 24;7(2):501-13.
Title:	Mnk2 alternative splicing modulates the p38-MAPK pathway and impacts Ras-induced transformation.
Author:	Maimon, Avraham\|Mogilevsky, Maxim\|Shilo, Asaf\|Golan-Gerstl, Regina\|Obiedat, Akram\|Ben-Hur, Vered\|Lebenthal-Loinger, Ilana\|Stein, Ilan\|Reich, Reuven\|Beenstock, Jonah\|Zehorai, Eldar\|Andersen, Claus L\|Thorsen, Kasper\|Orntoft, Torben F\|Davis, Roger J\|Davidson
PMID:	24726367

29.
Journal:	J Cell Sci. 2014 Feb 15;127(Pt 4):788-800.
Title:	Adaptation to mTOR kinase inhibitors by amplification of eIF4E to maintain cap-dependent translation.
Author:	Cope, Claire L\|Gilley, Rebecca\|Balmanno, Kathryn\|Sale, Matthew J\|Howarth, Karen D\|Hampson, Mark\|Smith, Paul D\|Guichard, Sylvie M\|Cook, Simon J
PMID:	24363449

30.
Journal:	Oncogene. 2014 Apr 3;33(14):1828-39.
Title:	ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer.
Author:	Ye, Q\|Cai, W\|Zheng, Y\|Evers, B M\|She, Q-B
PMID:	23624914

31.
Journal:	Cell Biosci. 2014 Apr 28;4:23.
Title:	Protein expression of eIF4E and integrin alphavbeta6 in colon cancer can predict clinical significance, reveal their correlation and imply possible mechanism of interaction.
Author:	Niu, Zhengchuan\|Wang, Jiayong\|Muhammad, Shahbaz\|Niu, Weibo\|Liu, Enyu\|Peng, Cheng\|Liang, Benjia\|Sun, Qi\|Obo, Shinichi\|He, Zhaobin\|Liu, Song\|Zou, Xueqing\|Niu, Jun
PMID:	24839543

32.
Journal:	Cancer Lett. 2015 Feb 28;357(2):582-90.
Title:	Dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor is an effective radiosensitizer for colorectal cancer.
Author:	Chen, Yu-Hsuan\|Wei, Ming-Feng\|Wang, Chun-Wei\|Lee, Hsiao-Wei\|Pan, Shiow-Lin\|Gao, Ming\|Kuo, Sung-Hsin\|Cheng, Ann-Lii\|Teng, Che-Ming
PMID:	25497009

33.
Journal:	Int J Clin Exp Pathol. 2015 Jan 1;8(1):404-13. eCollection 2015.
Title:	Expression of eukaryotic initiation factor 4E and 4E binding protein 1 in colorectal carcinogenesis.
Author:	Diab-Assaf, Mona\|Abou-Khouzam, Raefa\|Saadallah-Zeidan, Nina\|Habib, Khaled\|Bitar, Nizar\|Karam, Walid\|Liagre, Bertrand\|Harakeh, Steve\|Azar, Rania
PMID:	25755728

34.
Journal:	Anticancer Drugs. 2015 Jul;26(6):641-8.
Title:	Dehydrocostus lactone suppressed the proliferation, migration, and invasion of colorectal carcinoma through the downregulation of eIF4E expression.
Author:	Sun, Xiwen\|Kang, Haixian\|Yao, Yunhong\|Chen, Hongzhen\|Sun, Liping\|An, Weifang\|Jiang, Enping\|Wang, Sen\|Hu, Xinrong
PMID:	25850883

35.
Journal:	Cancer Discov. 2015 Jul;5(7):768-781.
Title:	Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer.
Author:	Wiegering, Armin\|Uthe, Friedrich W\|Jamieson, Thomas\|Ruoss, Yvonne\|Huttenrauch, Melanie\|Kuspert, Maritta\|Pfann, Christina\|Nixon, Colin\|Herold, Steffi\|Walz, Susanne\|Taranets, Lyudmyla\|Germer, Christoph-Thomas\|Rosenwald, Andreas\|Sansom, Owen J\|Eilers, Martin
PMID:	25934076

36.
Journal:	Cell Signal. 2015 Aug;27(8):1557-68.
Title:	Growth-factor dependent expression of the translationally controlled tumour protein TCTP is regulated through the PI3-K/Akt/mTORC1 signalling pathway.
Author:	Bommer, Ulrich-Axel\|Iadevaia, Valentina\|Chen, Jiezhong\|Knoch, Bianca\|Engel, Martin\|Proud, Christopher G
PMID:	25936523

37.
Journal:	Tumour Biol. 2015 Aug;36(8):6541-50.
Title:	Integrin beta6 can be translationally regulated by eukaryotic initiation factor 4E: Contributing to colonic tumor malignancy.
Author:	Enyu, Liu\|Zhengchuan, Niu\|Jiayong, Wang\|Benjia, Liang\|Qi, Sun\|Ruixi, Qin\|Cheng, Peng\|Khan, Abdul Qadir\|Wei, Song\|Jun, Niu
PMID:	25982998

38.
Journal:	Oncotarget. 2015 Sep 8;6(26):22799-811.
Title:	Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3.
Author:	Zhang, Baolai\|Dong, Shuhong\|Zhu, Ruiming\|Hu, Chunyan\|Hou, Jing\|Li, Yan\|Zhao, Qian\|Shao, Xue\|Bu, Qian\|Li, Hongyu\|Wu, Yongjie\|Cen, Xiaobo\|Zhao, Yinglan
PMID:	26078354

39.
Journal:	Toxicon. 2016 Sep 1;119:140-51.
Title:	Insights into the potential of picoplanktonic marine cyanobacteria strains for cancer therapies - Cytotoxic mechanisms against the RKO colon cancer cell line.
Author:	Freitas, Sara\|Martins, Rosario\|Campos, Alexandre\|Azevedo, Joana\|Osorio, Hugo\|Costa, Margarida\|Barros, Piedade\|Vasconcelos, Vitor\|Urbatzka, Ralph
PMID:	27242042

40.
Journal:	Oncotarget. 2016 Dec 20;7(51):85502-85514.
Title:	Expression analysis and clinical significance of eIF4E, VEGF-C, E-cadherin and MMP-2 in colorectal adenocarcinoma.
Author:	Gao, Minna\|Zhang, Xiong\|Li, Dan\|He, Ping\|Tian, Wenguang\|Zeng, Bo
PMID:	27907907

41.
Journal:	Int J Cancer. 2016 Oct 1;139(7):1648-57.
Title:	Modulation of tumor eIF4E by antisense inhibition: A phase I/II translational clinical trial of ISIS 183750-an antisense oligonucleotide against eIF4E-in combination with irinotecan in solid tumors and irinotecan-refractory colorectal cancer.
Author:	Duffy, A G\|Makarova-Rusher, O V\|Ulahannan, S V\|Rahma, O E\|Fioravanti, S\|Walker, M\|Abdullah, S\|Raffeld, M\|Anderson, V\|Abi-Jaoudeh, N\|Levy, E\|Wood, B J\|Lee, S\|Tomita, Y\|Trepel, J B\|Steinberg, S M\|Revenko, A S\|MacLeod, A R\|Peer, C J\|Figg, W D\|Greten, T F
PMID:	27194579

42.
Journal:	Onco Targets Ther. 2016 Feb 19;9:815-22.
Title:	Overexpression of eIF4E in colorectal cancer patients is associated with liver metastasis.
Author:	Xu, Tao\|Zong, Yuanyuan\|Peng, Lipan\|Kong, Shuai\|Zhou, Mingliang\|Zou, Jianqiang\|Liu, Jinglei\|Miao, Ruizheng\|Sun, Xichao\|Li, Leping
PMID:	26929650

43.
Journal:	Oncogene. 2016 Jan 14;35(2):148-57.
Title:	mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation.
Author:	He, K\|Zheng, X\|Li, M\|Zhang, L\|Yu, J
PMID:	25867072

44.
Journal:	Anal Bioanal Chem. 2017 Mar;409(7):1749-1763.
Title:	Phosphoproteomics of colon cancer metastasis: comparative mass spectrometric analysis of the isogenic primary and metastatic cell lines SW480 and SW620.
Author:	Schunter, Alissa J\|Yue, Xiaoshan\|Hummon, Amanda B
PMID:	27987026

45.
Journal:	Oncotarget. 2017 Feb 7;8(6):9280-9292.
Title:	Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress.
Author:	Li, Xiangyun\|Li, Mei\|Ruan, Hang\|Qiu, Wei\|Xu, Xiang\|Zhang, Lin\|Yu, Jian
PMID:	28030835

46.
Journal:	Oncotarget. 2017 Mar 7;8(10):16765-16783.
Title:	Genetic variants in the TGFbeta-signaling pathway influence expression of miRNAs in colon and rectal normal mucosa and tumor tissue.
Author:	Slattery, Martha L\|Trivellas, Andromahi\|Pellatt, Andrew J\|Mullany, Lila E\|Stevens, John R\|Wolff, Roger K\|Herrick, Jennifer S
PMID:	28061442

47.
Journal:	Pathol Res Pract. 2017 May;213(5):490-495.
Title:	Eukaryotic translation initiation factor 4E (eIF-4E) expressions are associated with poor prognosis in colorectal adenocarcinoma.
Author:	Chen, Yi-Ting\|Tsai, Hung-Pei\|Wu, Chun-Chieh\|Wang, Jaw-Yuan\|Chai, Chee-Yin
PMID:	28242042

48.
Journal:	J Ethnopharmacol. 2017 May 5;203:27-38.
Title:	Imperatorin suppresses proliferation and angiogenesis of human colon cancer cell by targeting HIF-1alpha via the mTOR/p70S6K/4E-BP1 and MAPK pathways.
Author:	Mi, Chunliu\|Ma, Juan\|Wang, Ke Si\|Zuo, Hong Xiang\|Wang, Zhe\|Li, Ming Yue\|Piao, Lian Xun\|Xu, Guang Hua\|Li, Xuezheng\|Quan, Zhe Shan\|Jin, Xuejun
PMID:	28341244

49.
Journal:	Neoplasma. 2017;64(5):787-794.
Title:	Phosphorylated 4E-BP1 is associated with tumor progression and adverse prognosis in colorectal cancer.
Author:	Chen, Y\|Wang, J\|Fan, H\|Xie, J\|Xu, L\|Zhou, B
PMID:	28592131

50.
Journal:	Chem Biol Interact. 2017 Aug 25;274:58-67.
Title:	Shikonin suppresses proliferation and induces cell cycle arrest through the inhibition of hypoxia-inducible factor-1alpha signaling.
Author:	Li, Ming Yue\|Mi, Chunliu\|Wang, Ke Si\|Wang, Zhe\|Zuo, Hong Xiang\|Piao, Lian Xun\|Xu, Guang Hua\|Li, Xuezheng\|Ma, Juan\|Jin, Xuejun
PMID:	28684144

51.
Journal:	J Gastrointest Cancer. 2017 Nov 7. pii: 10.1007/s12029-017-0024-9.
Title:	A Deregulated PI3K-AKT Signaling Pathway in Patients with Colorectal Cancer.
Author:	Zhang, Tao\|Ma, Yuanping\|Fang, Jiansong\|Liu, Chang\|Chen, Liangrong
PMID:	29110225

52.
Journal:	Biochem Biophys Res Commun. 2018 Sep 18;503(4):2286-2292.
Title:	Inhibition of eukaryotic translation initiation factor 4E is effective against chemo-resistance in colon and cervical cancer.
Author:	Xi, Changlei\|Wang, Ling\|Yu, Jie\|Ye, Hui\|Cao, Longlei\|Gong, Zhilin
PMID:	29959920

53.
Journal:	Bioorg Med Chem. 2018 Sep 1;26(16):4602-4614.
Title:	Design and synthesis of novel 6-hydroxy-4-methoxy-3-methylbenzofuran-7-carboxamide derivatives as potent Mnks inhibitors by fragment-based drug design.
Author:	Wang, Shuxiang\|Li, Bo\|Liu, Bo\|Huang, Min\|Li, Deyi\|Guan, Lihong\|Zang, Jie\|Liu, Dan\|Zhao, Linxiang
PMID:	30115493

54.
Journal:	Mol Oncol. 2018 Sep 17.
Title:	Metformin blocks MYC protein synthesis in colorectal cancer via mTOR-4EBP-eIF4E and MNK-1-eIF4G-eIF4E signaling.
Author:	Shen, Peng\|Reineke, Lucas C\|Knutsen, Erik\|Chen, Meng\|Pichler, Martin\|Ling, Hui\|Calin, George A
PMID:	30221473