Primary Site >> Colorectal Cancer
Gene >> EIF4E
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Ref: 4E binding protein 1 expression is inversely correlated to the progression of gastrointestinal cancers. PMID: 10785360 Ref: Translational control of malignancy: the mRNA cap-binding protein, eIF-4E, as a central regulator of tumor formation, growth, invasion and metastasis. PMID: 10928042 |
Ref: Expression of the translation initiation factor eIF4E in the polyp-cancer sequence in the colon. PMID: 11401917 Ref: Ectopic expression of eIF-4E in human colon cancer cells promotes the stimulation of adhesion molecules by transforming growth factorbeta. PMID: 11771728 |
Ref: 4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin. PMID: 11847216 Ref: Predominant nuclear localization of mammalian target of rapamycin in normal and malignant cells in culture. PMID: 12000755 Ref: Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. PMID: 12149254 |
Ref: Contribution of eIF-4E inhibition to the expression and activity of heparanase in human colon adenocarcinoma cell line: LS-174T. PMID: 12918105 Ref: [Role of eukaryotic initiation factor-4E (eIF-4E) in regulation of expression of NF-kappaB and its subsequent influence on transcription and activity of heparanase in human colon adenocarcinoma cell line]. PMID: 14558943 |
Ref: Global alterations in mRNA polysomal recruitment in a cell model of colorectal cancer progression to metastasis. PMID: 16531451 |
Ref: Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1. PMID: 17440067 |
Ref: Validation of biomarkers associated with 5-fluorouracil and thymidylate synthase in colorectal cancer. PMID: 18097604 Ref: Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors. PMID: 18332469 Ref: The database dbEST correctly predicts gene expression in colon cancer patients. PMID: 19075689 |
Ref: Phosphorylated eukaryotic translation initiation factor 4 (eIF4E) is elevated in human cancer tissues. PMID: 19483468 |
Ref: Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci. PMID: 20459617 Ref: Modulation of 4E-BP1 function as a critical determinant of enzastaurin-induced apoptosis. PMID: 20971826 Ref: miRNA-145 inhibits non-small cell lung cancer cell proliferation by targeting c-Myc. PMID: 21092188 |
Ref: Associations between genetic variation in RUNX1, RUNX2, RUNX3, MAPK1 and eIF4E and riskof colon and rectal cancer: additional support for a TGF-beta-signaling pathway. PMID: 21088106 Ref: Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases. PMID: 21233335 Ref: Genetic variation in the transforming growth factor-beta signaling pathway and survival after diagnosis with colon and rectal cancer. PMID: 21365634 |
Ref: Dual inhibition of EGFR and c-Met kinase activation by MJ-56 reduces metastasis of HT29 human colorectal cancer cells. PMID: 23677180 Ref: Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA-21 mediated programmed cell death 4 (PDCD4) expression. PMID: 23827854 Ref: The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells. PMID: 24030632 Ref: Translational control in the stress adaptive response of cancer cells: a novel role for the heat shock protein TRAP1. PMID: 24113185 |
Ref: ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer. PMID: 23624914 Ref: Adaptation to mTOR kinase inhibitors by amplification of eIF4E to maintain cap-dependent translation. PMID: 24363449 Ref: Mnk2 alternative splicing modulates the p38-MAPK pathway and impacts Ras-induced transformation. PMID: 24726367 Ref: Protein expression of eIF4E and integrin alphavbeta6 in colon cancer can predict clinical significance, reveal their correlation and imply possible mechanism of interaction. PMID: 24839543 Ref: Alpha-2-glycoprotein 1(AZGP1) regulates biological behaviors of LoVo cells by down-regulating mTOR signaling pathway and endogenous fatty acid synthesis. PMID: 24918753 Ref: New insights into 4E-BP1-regulated translation in cancer progression and metastasis. PMID: 26005705 |
Ref: Dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor is an effective radiosensitizer for colorectal cancer. PMID: 25497009 Ref: Expression of eukaryotic initiation factor 4E and 4E binding protein 1 in colorectal carcinogenesis. PMID: 25755728 Ref: Dehydrocostus lactone suppressed the proliferation, migration, and invasion of colorectal carcinoma through the downregulation of eIF4E expression. PMID: 25850883 Ref: Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer. PMID: 25934076 Ref: Growth-factor dependent expression of the translationally controlled tumour protein TCTP is regulated through the PI3-K/Akt/mTORC1 signalling pathway. PMID: 25936523 Ref: Integrin beta6 can be translationally regulated by eukaryotic initiation factor 4E: Contributing to colonic tumor malignancy. PMID: 25982998 Ref: Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3. PMID: 26078354 |
Ref: mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation. PMID: 25867072 Ref: Overexpression of eIF4E in colorectal cancer patients is associated with liver metastasis. PMID: 26929650 Ref: Modulation of tumor eIF4E by antisense inhibition: A phase I/II translational clinical trial of ISIS 183750-an antisense oligonucleotide against eIF4E-in combination with irinotecan in solid tumors and irinotecan-refractory colorectal cancer. PMID: 27194579 Ref: Insights into the potential of picoplanktonic marine cyanobacteria strains for cancer therapies - Cytotoxic mechanisms against the RKO colon cancer cell line. PMID: 27242042 Ref: Expression analysis and clinical significance of eIF4E, VEGF-C, E-cadherin and MMP-2 in colorectal adenocarcinoma. PMID: 27907907 |
Ref: Phosphoproteomics of colon cancer metastasis: comparative mass spectrometric analysis of the isogenic primary and metastatic cell lines SW480 and SW620. PMID: 27987026 Ref: Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress. PMID: 28030835 Ref: Genetic variants in the TGFbeta-signaling pathway influence expression of miRNAs in colon and rectal normal mucosa and tumor tissue. PMID: 28061442 Ref: Eukaryotic translation initiation factor 4E (eIF-4E) expressions are associated with poor prognosis in colorectal adenocarcinoma. PMID: 28242042 Ref: Imperatorin suppresses proliferation and angiogenesis of human colon cancer cell by targeting HIF-1alpha via the mTOR/p70S6K/4E-BP1 and MAPK pathways. PMID: 28341244 Ref: Phosphorylated 4E-BP1 is associated with tumor progression and adverse prognosis in colorectal cancer. PMID: 28592131 Ref: Shikonin suppresses proliferation and induces cell cycle arrest through the inhibition of hypoxia-inducible factor-1alpha signaling. PMID: 28684144 Ref: A Deregulated PI3K-AKT Signaling Pathway in Patients with Colorectal Cancer. PMID: 29110225 |
Ref: Inhibition of eukaryotic translation initiation factor 4E is effective against chemo-resistance in colon and cervical cancer. PMID: 29959920 Ref: Design and synthesis of novel 6-hydroxy-4-methoxy-3-methylbenzofuran-7-carboxamide derivatives as potent Mnks inhibitors by fragment-based drug design. PMID: 30115493 Ref: Metformin blocks MYC protein synthesis in colorectal cancer via mTOR-4EBP-eIF4E and MNK-1-eIF4G-eIF4E signaling. PMID: 30221473 |