Primary Site >> Colorectal Cancer

Gene >> E2F4

Journal: Biochem Biophys Res Commun. 1996 Oct 14;227(2):553-7.
Title: Mutations of E2F-4 trinucleotide repeats in colorectal cancer with microsatellite instability.
Author: Yoshitaka, T|Matsubara, N|Ikeda, M|Tanino, M|Hanafusa, H|Tanaka, N|Shimizu, K
PMID: 8878551
Journal: Cancer Res. 1997 Jun 15;57(12):2350-3.
Title: Frequent mutation of the E2F-4 cell cycle gene in primary human gastrointestinal tumors.
Author: Souza, R F|Yin, J|Smolinski, K N|Zou, T T|Wang, S|Shi, Y Q|Rhyu, M G|Cottrell, J|Abraham, J M|Biden, K|Simms, L|Leggett, B|Bova, G S|Frank, T|Powell, S M|Sugimura, H|Young, J|Harpaz, N|Shimizu, K|Matsubara, N|Meltzer, S J
PMID: 9192806
Journal: Oncogene. 1997 Dec 4;15(23):2877-81.
Title: Drastic genetic instability of tumors and normal tissues in Turcot syndrome.
Author: Miyaki, M|Nishio, J|Konishi, M|Kikuchi-Yanoshita, R|Tanaka, K|Muraoka, M|Nagato, M|Chong, J M|Koike, M|Terada, T|Kawahara, Y|Fukutome, A|Tomiyama, J|Chuganji, Y|Momoi, M|Utsunomiya, J
PMID: 9419979
Journal: Cancer Res. 1998 Feb 15;58(4):594-8.
Title: Close correlation between mutations of E2F4 and hMSH3 genes in colorectal cancers with microsatellite instability.
Author: Ikeda, M|Orimo, H|Moriyama, H|Nakajima, E|Matsubara, N|Mibu, R|Tanaka, N|Shimada, T|Kimura, A|Shimizu, K
PMID: 9485005
Journal: Am J Pathol. 1998 Oct;153(4):1063-78.
Title: Accumulated clonal genetic alterations in familial and sporadic colorectal carcinomas with widespread instability in microsatellite sequences.
Author: Fujiwara, T|Stolker, J M|Watanabe, T|Rashid, A|Longo, P|Eshleman, J R|Booker, S|Lynch, H T|Jass, J R|Green, J S|Kim, H|Jen, J|Vogelstein, B|Hamilton, S R
PMID: 9777938
Journal: Cancer Res. 1999 Jan 15;59(2):462-6.
Title: Causes and consequences of microsatellite instability in endometrial carcinoma.
Author: Gurin, C C|Federici, M G|Kang, L|Boyd, J
PMID: 9927063
Journal: Int J Oncol. 2000 Jan;16(1):133-9.
Title: The effect of mismatch repair deficiency on tumourigenesis; microsatellite instability affecting genes containing short repeated sequences.
Author: Johannsdottir, J T|Jonasson, J G|Bergthorsson, J T|Amundadottir, L T|Magnusson, J|Egilsson, V|Ingvarsson, S
PMID: 10601558
Journal: Int J Oncol. 2000 Apr;16(4):731-7.
Title: Analysis of the candidate target genes for mutation in microsatellite instability-positive cancers of the colorectum, stomach, and endometrium.
Author: Semba, S|Ouyang, H|Han, S Y|Kato, Y|Horii, A
PMID: 10717241
Journal: Int J Cancer. 2000 Jun 1;86(5):672-7.
Title: Genomic structure and mutation screening of the E2F4 gene in human tumors.
Author: Schwemmle, S|Pfeifer, G P
PMID: 10797289
Journal: Digestion. 2000;62(2-3):213-6.
Title: Multiple tumors and a novel E2F-4 mutation. A case report.
Author: Matsubara, N|Yoshitaka, T|Matsuno, T|Ikeda, M|Isozaki, H|Tanaka, N|Shimizu, K
PMID: 11025371
Journal: Oncogene. 2001 Aug 23;20(37):5215-8.
Title: Alterations of repeated sequences in 5' upstream and coding regions in colorectal tumors from patients with hereditary nonpolyposis colorectal cancer and Turcot syndrome.
Author: Miyaki, M|Iijima, T|Shiba, K|Aki, T|Kita, Y|Yasuno, M|Mori, T|Kuroki, T|Iwama, T
PMID: 11526511
Journal: Lab Invest. 2001 Nov;81(11):1565-73.
Title: Effect of naturally occurring E2F-4 alterations on transcriptional activation and proliferation in transfected cells.
Author: Takashima, H|Matsumoto, Y|Matsubara, N|Shirakawa, Y|Kawashima, R|Tanino, M|Ito, S|Isozaki, H|Ouchida, M|Meltzer, S J|Shimizu, K|Tanaka, N
PMID: 11706064
Journal: Cancer Genet Cytogenet. 2002 Apr 1;134(1):46-54.
Title: Cytogenetic aberrations and heterogeneity of mutations in repeat-containing genes in a colon carcinoma from a patient with hereditary nonpolyposis colorectal cancer.
Author: Planck, Maria|Halvarsson, Britta|Palsson, Eva|Hallen, Magnus|Ekelund, Mats|Palsson, Birger|Baldetorp, Bo|Nilbert, Mef
PMID: 11996796
Journal: J Exp Clin Cancer Res. 2002 Jun;21(2):185-9.
Title: E2F-4 mutation in hereditary non-polyposis colorectal cancer.
Author: Moriyama, H|Sasamoto, H|Kambara, T|Matsubara, N|Ikeda, M|Baba, S|Meltzer, S J|Lynch, H T|Shimizu, K|Tanaka, N
PMID: 12148576
Journal: Appl Immunohistochem Mol Morphol. 2002 Sep;10(3):225-30.
Title: Expression of E2F-4 gene in colorectal adenocarcinoma and corresponding covering mucosa: an immunohistochemistry, image analysis, and immunoblot study.
Author: Mady, Hussam H|Hasso, Sean|Melhem, Mona F
PMID: 12373148
Journal: Mol Cancer Ther. 2003 Jun;2(6):535-41.
Title: mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma.
Author: Sowers, Rebecca|Toguchida, Junya|Qin, Jing|Meyers, Paul A|Healey, John H|Huvos, Andrew|Banerjee, Debabrata|Bertino, Joseph R|Gorlick, Richard
PMID: 12813132
Journal: J Cell Physiol. 2004 May;199(2):262-73.
Title: The nucleocytoplasmic shuttling of E2F4 is involved in the regulation of human intestinal epithelial cell proliferation and differentiation.
Author: Deschenes, Claude|Alvarez, Laetitia|Lizotte, Marie-Eve|Vezina, Anne|Rivard, Nathalie
PMID: 15040009
Journal: Oncogene. 2004 Aug 19;23(37):6250-60.
Title: Expression of MCM10 and TopBP1 is regulated by cell proliferation and UV irradiation via the E2F transcription factor.
Author: Yoshida, Kenichi|Inoue, Ituro
PMID: 15195143
Journal: Oncol Rep. 2006 Dec;16(6):1245-52.
Title: Molecular mechanisms underlying the tumorigenesis of colorectal adenomas: correlation to activated K-ras oncogene.
Author: Wang, Jaw-Yuan|Wang, Yung-Hsin|Jao, Shu-Wen|Lu, Chien-Yu|Kuo, Chao-Hung|Hu, Huang-Ming|Hsieh, Jan-Sing|Chong, Inn-Wen|Cheng, Tian-Lu|Lin, Shiu-Ru
PMID: 17089045
Journal: J Biol Chem. 2007 Jan 12;282(2):871-8. Epub 2006 Nov 22.
Title: An antisense transcript induced by Wnt/beta-catenin signaling decreases E2F4.
Author: Yochum, Gregory S|Cleland, Ryan|McWeeney, Shannon|Goodman, Richard H
PMID: 17121828
Journal: Am J Physiol Gastrointest Liver Physiol. 2007 Oct;293(4):G758-72. Epub 2007 Jul
Title: Nuclear expression of E2F4 induces cell death via multiple pathways in normal human intestinal epithelial crypt cells but not in colon cancer cells.
Author: Garneau, Hugo|Alvarez, Laetitia|Paquin, Marie-Christine|Lussier, Carine|Rancourt, Claudine|Tremblay, Eric|Beaulieu, Jean-Francois|Rivard, Nathalie
PMID: 17656449
Journal: J Biol Chem. 2009 Aug 21;284(34):22916-25.
Title: Mirk regulates the exit of colon cancer cells from quiescence.
Author: Jin, Kideok|Ewton, Daina Z|Park, Sunju|Hu, Jing|Friedman, Eileen
PMID: 19542220
Journal: J Cell Physiol. 2009 Nov;221(2):350-8.
Title: E2F4 expression is required for cell cycle progression of normal intestinal crypt cells and colorectal cancer cells.
Author: Garneau, Hugo|Paquin, Marie-Christine|Carrier, Julie C|Rivard, Nathalie
PMID: 19562678
Journal: Int J Cancer. 2009 Nov 1;125(9):2086-94.
Title: E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin.
Author: Chimploy, Korakod|Diaz, G Dario|Li, Qingjie|Carter, Orianna|Dashwood, Wan-Mohaiza|Mathews, Christopher K|Williams, David E|Bailey, George S|Dashwood, Roderick H
PMID: 19585502
Journal: Korean J Physiol Pharmacol. 2010 Dec;14(6):391-7.
Title: Curcumin Induces Downregulation of E2F4 Expression and Apoptotic Cell Death in HCT116 Human Colon Cancer Cells; Involvement of Reactive Oxygen Species.
Author: Kim, Kyung-Chan|Lee, Chuhee
PMID: 21311680
Journal: Br J Cancer. 2013 May 28;108(10):2013-20.
Title: 212Pb-radioimmunotherapy potentiates paclitaxel-induced cell killing efficacy by perturbing the mitotic spindle checkpoint.
Author: Yong, K J|Milenic, D E|Baidoo, K E|Brechbiel, M W
PMID: 23632482
Journal: World J Gastroenterol. 2013 Jun 7;19(21):3189-98.
Title: E2F transcription factors and digestive system malignancies: how much do we know?
Author: Xanthoulis, Athanasios|Tiniakos, Dina G
PMID: 23745020
Journal: Int J Oncol. 2013 Dec;43(6):2015-22.
Title: Functional impact of colorectal cancer-associated mutations in the transcription factor E2F4.
Author: Paquin, Marie-Christine|Leblanc, Caroline|Lemieux, Etienne|Bian, Benjamin|Rivard, Nathalie
PMID: 24100580
Journal: Appl Immunohistochem Mol Morphol. 2014 Jul;22(6):471-7.
Title: The relationship between E2F family members and tumor growth in colorectal adenocarcinomas: A comparative immunohistochemical study of 100 cases.
Author: Xanthoulis, Athanasios|Kotsinas, Athanassios|Tiniakos, Dina|Fiska, Aliki|Tentes, Antonios-Apostolos|Kyroudi, Aspasia|Kittas, Christos|Gorgoulis, Vassilios
PMID: 22688350
Journal: PLoS One. 2017 Jun 19;12(6):e0178760.
Title: A multidimensional integration analysis reveals potential bridging targets in the process of colorectal cancer liver metastasis.
Author: Gao, Bo|Yu, Tian|Xue, Dongbo|Sun, Boshi|Shao, Qin|Choudhry, Hani|Marcus, Victoria|Ragoussis, Jiannis|Zhang, Yuguo|Zhang, Weihui|Gao, Zu-Hua
PMID: 28628609
Journal: Oncol Lett. 2017 Oct;14(4):4793-4799.
Title: Inhibition of BAMBI reduces the viability and motility of colon cancer via activating TGF-beta/Smad pathway in vitro and in vivo.
Author: Yu, Wenzhen|Chai, Hong
PMID: 29085481
Journal: Genomics Proteomics Bioinformatics. 2018 Feb;16(1):73-84.
Title: The Immunome of Colon Cancer: Functional In Silico Analysis of Antigenic Proteins Deduced from IgG Microarray Profiling.
Author: Luna Coronell, Johana A|Sergelen, Khulan|Hofer, Philipp|Gyurjan, Istvan|Brezina, Stefanie|Hettegger, Peter|Leeb, Gernot|Mach, Karl|Gsur, Andrea|Weinhausel, Andreas
PMID: 29505855