Primary Site >> Liver Cancer
Gene >> DPYD
| 1. | |||||||||||
| Journal: | Clin Cancer Res. 1997 Mar;3(3):395-9. | ||||||||||
| Title: | Dihydropyrimidine dehydrogenase activity in hepatocellular carcinoma: implication in 5-fluorouracil-based chemotherapy. | ||||||||||
| Author: | Jiang, W|Lu, Z|He, Y|Diasio, R B | ||||||||||
| PMID: | 9815697 | ||||||||||
| 2. | |||||||||||
| Journal: | Int J Oncol. 2000 Jul;17(1):33-8. | ||||||||||
| Title: | Expression levels of thymidine phosphorylase and dihydropyrimidine dehydrogenase in various human tumor tissues. | ||||||||||
| Author: | Mori, K|Hasegawa, M|Nishida, M|Toma, H|Fukuda, M|Kubota, T|Nagasue, N|Yamana, H|Hirakawa-YS Chung, K|Ikeda, T|Takasaki, K|Oka, M|Kameyama, M|Toi, M|Fujii, H|Kitamura, M|Murai, M|Sasaki, H|Ozono, S|Makuuchi, H|Shimada, Y|Onishi, Y|Aoyagi, S|Mizutani, K|Oga | ||||||||||
| PMID: | 10853015 | ||||||||||
| 3. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2000 Oct;27(12):1879-82. | ||||||||||
| Title: | [Clinical significance of determinations of dihydropyrimidine dehydrogenase levels in primary and hepatic lesions of colorectal cancer patients]. | ||||||||||
| Author: | Ishida, H|Hashimoto, D|Inokuma, S|Takeuchi, I|Nakada, H|Ohsawa, T|Hoshino, T|Murata, N|Fujioka, M|Idezuki, Y | ||||||||||
| PMID: | 11086435 | ||||||||||
| 4. | |||||||||||
| Journal: | Oncol Rep. 2001 May-Jun;8(3):621-5. | ||||||||||
| Title: | Dihydropyrimidine dehydrogenase activity of cancerous and non-cancerous tissues in liver and large intestine. | ||||||||||
| Author: | Ikeguchi, M|Hirooka, Y|Makino, M|Kaibara, N | ||||||||||
| PMID: | 11295091 | ||||||||||
| 5. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2001 Oct;28(11):1624-7. | ||||||||||
| Title: | [Effect of peroral doxifluridine plus hepatic arterial infusion for synchronous liver metastasis of colorectal cancer--correlation with the expression of thymidine phosphorylase and dihydropyrimidine dehydrogenase in primary colorectal cancer lesions]. | ||||||||||
| Author: | Ishida, H|Fujioka, M|Ohsawa, T|Takeuchi, I|Nakada, H|Ishizuka, N|Yokoyama, M|Inokuma, S|Yamada, H|Odaka, A|Hoshino, T|Murata, N|Hashimoto, D|Matsumoto, Y|Miura, T | ||||||||||
| PMID: | 11707995 | ||||||||||
| 6. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2002 Apr;29(4):625-8. | ||||||||||
| Title: | [A case of liver metastasis of rectal cancer demonstrating complete response to 5-FU + Leucovorin + UFT]. | ||||||||||
| Author: | Ishida, Hideyuki|Ohsawa, Tomonori|Takeuchi, Ikuya|Nakada, Hiroshi|Inokuma, Shigehisa|Hoshino, Takanobu|Daijo, Hashimoto | ||||||||||
| PMID: | 11977552 | ||||||||||
| 7. | |||||||||||
| Journal: | Biochim Biophys Acta. 2002 Jul 18;1587(2-3):164-73. | ||||||||||
| Title: | Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase. | ||||||||||
| Author: | Banerjee, Debabrata|Mayer-Kuckuk, Philipp|Capiaux, Gina|Budak-Alpdogan, Tulin|Gorlick, Richard|Bertino, Joseph R | ||||||||||
| PMID: | 12084458 | ||||||||||
| 8. | |||||||||||
| Journal: | Cancer Chemother Pharmacol. 2003 Dec;52(6):469-76. | ||||||||||
| Title: | Dihydropyrimidine dehydrogenase and thymidylate synthase activities in hepatocellular carcinomas and in diseased livers. | ||||||||||
| Author: | Baba, Hiroyuki|Teramoto, Kenichi|Kawamura, Toru|Mori, Akira|Imamura, Masayuki|Arii, Shigeki | ||||||||||
| PMID: | 13680162 | ||||||||||
| 9. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2004 Oct;31(10):1511-5. | ||||||||||
| Title: | [Influence on 5-fluorouracil metabolism by combination of interferon-alpha and 5-fluorouracil against human hepatocellular carcinoma xenografts]. | ||||||||||
| Author: | Jin, Chang De|Yamamoto, Tameyoshi|Nakamura, Masato|Arai, Isao|Kishin, Rho|Xing, Xu|Nagano, Hiroaki|Dono, Keizo|Umeshita, Koji|Nakamori, Shoji|Sakon, Masato|Monden, Morito | ||||||||||
| PMID: | 15508442 | ||||||||||
| 10. | |||||||||||
| Journal: | Oncol Rep. 2004 Aug;12(2):347-51. | ||||||||||
| Title: | Thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in hepatocellular carcinoma and metastatic liver cancer. | ||||||||||
| Author: | Hotta, Tsukasa|Kobayashi, Yasuhito|Taniguchi, Katsutoshi|Johata, Kiyofumi|Sahara, Masaki|Watanabe, Takashi|Ochiai, Minoru|Tanimura, Hiroshi|Tsubota, Yukari T | ||||||||||
| PMID: | 15254700 | ||||||||||
| 11. | |||||||||||
| Journal: | Cancer Chemother Pharmacol. 2004 Apr;53(4):296-304. | ||||||||||
| Title: | The efficacy of the combination therapy of 5-fluorouracil, cisplatin and leucovorin for hepatocellular carcinoma and its predictable factors. | ||||||||||
| Author: | Kogure, Takayuki|Ueno, Yoshiyuki|Iwasaki, Takao|Shimosegawa, Toru | ||||||||||
| PMID: | 14689231 | ||||||||||
| 12. | |||||||||||
| Journal: | Liver Int. 2005 Feb;25(1):148-52. | ||||||||||
| Title: | Consensus interferon enhances the anti-proliferative effect of 5-fluorouracil on human hepatoma cells via downregulation of dihydropyrimidine dehydrogenase expression. | ||||||||||
| Author: | Dou, Jian|Iwashita, Yukio|Sasaki, Atsushi|Kai, Seiichiro|Hirano, Seitaro|Ohta, Masayuki|Kitano, Seigo | ||||||||||
| PMID: | 15698412 | ||||||||||
| 13. | |||||||||||
| Journal: | Oncol Rep. 2005 Nov;14(5):1223-30. | ||||||||||
| Title: | Immunohistochemical demonstration of fluoropyrimidine-metabolizing enzymes in various types of cancer. | ||||||||||
| Author: | Kamoshida, Shingo|Shiogama, Kazuya|Shimomura, Ryoichi|Inada, Ken-Ichi|Sakurai, Yoichi|Ochiai, Masahiro|Matuoka, Hiroshi|Maeda, Kotaro|Tsutsumi, Yutaka | ||||||||||
| PMID: | 16211289 | ||||||||||
| 14. | |||||||||||
| Journal: | Oncol Rep. 2006 Apr;15(4):875-82. | ||||||||||
| Title: | Correlation between chemosensitivity and mRNA expression level of 5-fluorouracil-related metabolic enzymes during liver metastasis of colorectal cancer. | ||||||||||
| Author: | Okumura, Kenji|Shiomi, Hisanori|Mekata, Eiji|Kaizuka, Machiko|Endo, Yoshihiro|Kurumi, Yoshimasa|Tani, Tohru | ||||||||||
| PMID: | 16525674 | ||||||||||
| 15. | |||||||||||
| Journal: | Gan To Kagaku Ryoho. 2007 Jun;34(6):957-9. | ||||||||||
| Title: | [Anti-tumor effects of various interferons-alpha +5-fluorouracil via downregulation of dihydropyrimidine dehydrogenase in hepatoma cells]. | ||||||||||
| Author: | Fan, Xiao Yan|Uchida, Hiroki|Iwaki, Kentaro|Kai, Seiichiro|Shibata, Kohei|Ohta, Masayuki|Kitano, Seigo | ||||||||||
| PMID: | 17565266 | ||||||||||
| 16. | |||||||||||
| Journal: | Mol Cancer Ther. 2007 Aug;6(8):2310-8. | ||||||||||
| Title: | Alteration of dihydropyrimidine dehydrogenase expression by IFN-alpha affects the antiproliferative effects of 5-fluorouracil in human hepatocellular carcinoma cells. | ||||||||||
| Author: | Oie, Shinji|Ono, Mayumi|Fukushima, Hiroto|Hosoi, Fumihito|Yano, Hirohisa|Maruyama, Yuichiro|Kojiro, Masamichi|Terada, Tadafumi|Hirano, Kazuyuki|Kuwano, Michihiko|Yamada, Yuji | ||||||||||
| PMID: | 17699726 | ||||||||||
| 17. | |||||||||||
| Journal: | Hepatogastroenterology. 2007 Sep;54(78):1612-6. | ||||||||||
| Title: | Profiling of fluorouracil-related genes by microdissection technique in hepatocellular carcinoma. | ||||||||||
| Author: | Takahashi, Tsubasa|Yoshida, Hiroshi|Mamada, Yasuhiro|Taniai, Nobuhiko|Mizuguchi, Yoshiaki|Shimizu, Tetsuya|Kakinuma, Daisuke|Ishikawa, Yoshinori|Akimaru, Koho|Sugisaki, Yuichi|Tajiri, Takashi | ||||||||||
| PMID: | 18019677 | ||||||||||
| 18. | |||||||||||
| Journal: | J Chemother. 2007 Dec;19(6):709-15. | ||||||||||
| Title: | Gene expression of 5-fluorouracil metabolic enzymes in hepatocellular carcinoma and non-tumor tissue. | ||||||||||
| Author: | Sunaga, M|Tomonaga, T|Yoshikawa, M|Ebara, M|Shimada, H|Saisho, H|Nomura, F | ||||||||||
| PMID: | 18230555 | ||||||||||
| 19. | |||||||||||
| Journal: | Hepatol Res. 2009 Mar;39(3):274-81. | ||||||||||
| Title: | Significance of dihydropyrimidine dehydrogenase and thymidylate synthase mRNA expressions in hepatocellular carcinoma. | ||||||||||
| Author: | Nii, Akira|Shimada, Mitsuo|Ikegami, Toru|Harino, Yukari|Imura, Satoru|Morine, Yuji|Kanemura, Hirofumi|Arakawa, Yusuke|Sugimoto, Koji | ||||||||||
| PMID: | 19054147 | ||||||||||
| 20. | |||||||||||
| Journal: | Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12938-43. | ||||||||||
| Title: | Identification of genes conferring resistance to 5-fluorouracil. | ||||||||||
| Author: | Yoo, Byoung Kwon|Gredler, Rachel|Vozhilla, Nicollaq|Su, Zao-zhong|Chen, Dong|Forcier, Talitha|Shah, Khalid|Saxena, Utsav|Hansen, Ulla|Fisher, Paul B|Sarkar, Devanand | ||||||||||
| PMID: | 19622726 | ||||||||||
| 21. | |||||||||||
| Journal: | Chemotherapy. 2009;55(2):76-82. | ||||||||||
| Title: | Phase II study of UFT with leucovorin plus hepatic arterial infusion with irinotecan, 5-fluorouracil and leucovorin for non-resectable liver metastases of colorectal cancer. | ||||||||||
| Author: | Idelevich, Efraim|Greif, Franklin|Mavor, Eli|Miller, Rafael|Kashtan, Hanoch|Susmalian, Sergo|Ariche, Arie|Brenner, Baruch|Baruch, Noa Ben|Dinerman, Michael|Shani, Adi | ||||||||||
| PMID: | 19077422 | ||||||||||
| 22. | |||||||||||
| Journal: | Cancer Chemother Pharmacol. 2010 Feb;65(3):481-9. | ||||||||||
| Title: | Synergistic effect of 5-fluorouracil and the flavanoid oroxylin A on HepG2 human hepatocellular carcinoma and on H22 transplanted mice. | ||||||||||
| Author: | Zhao, Li|Chen, Zhen|Wang, Jun|Yang, Li|Zhao, Qing|Wang, Jia|Qi, Qi|Mu, Rong|You, Qi-Dong|Guo, Qing-Long | ||||||||||
| PMID: | 19585117 | ||||||||||
| 23. | |||||||||||
| Journal: | Anticancer Res. 2010 Dec;30(12):5245-50. | ||||||||||
| Title: | Combination chemotherapy with S-1 and platinum in advanced hepatocellular carcinoma. | ||||||||||
| Author: | Kim, Su-Jung|Han, Sae-Won|Oh, Do-Youn|Yi, Nam-Joon|Kim, Yoon Jun|Im, Seock-Ah|Yoon, Jung-Hwan|Kang, Gyeong Hoon|Suh, Kyung Suk|Bang, Yung-Jue|Jang, Ja-Joon|Kim, Tae-You | ||||||||||
| PMID: | 21187521 | ||||||||||
| 24. | |||||||||||
| Journal: | J Gastroenterol. 2011 Feb;46(2):212-21. | ||||||||||
| Title: | The cancer stem cell marker CD133 is a predictor of the effectiveness of S1+ pegylated interferon alpha-2b therapy against advanced hepatocellular carcinoma. | ||||||||||
| Author: | Hagiwara, Satoru|Kudo, Masatoshi|Ueshima, Kazuomi|Chung, Hobyung|Yamaguchi, Mami|Takita, Masahiro|Haji, Seiji|Kimura, Masatomo|Arao, Tokuzo|Nishio, Kazuto|Park, Ah-Mee|Munakata, Hiroshi | ||||||||||
| PMID: | 20683621 | ||||||||||
| 25. | |||||||||||
| Journal: | Biopharm Drug Dispos. 2011 Mar;32(2):126-30. | ||||||||||
| Title: | Hepatic fibrosis does not affect the pharmacokinetics of 5-fluorouracil in rats. | ||||||||||
| Author: | Nagata, Masashi|Hidaka, Yumi|Hatakeyama, Kinta|Kawano, Yohei|Iwakiri, Tomomi|Okumura, Manabu|Arimori, Kazuhiko | ||||||||||
| PMID: | 21341281 | ||||||||||
| 26. | |||||||||||
| Journal: | Oncol Lett. 2012 May;3(5):983-989. | ||||||||||
| Title: | Thymidylate synthase and thymidine phosphorylase mRNA expression in primary lesions using laser capture microdissection is useful for prediction of the efficacy of FOLFOX treatment in colorectal cancer patients with liver metastasis. | ||||||||||
| Author: | Kumamoto, Kensuke|Kuwabara, Koki|Tajima, Yusuke|Amano, Kunihiko|Hatano, Satoshi|Ohsawa, Tomonori|Okada, Norimichi|Ishibashi, Keiichiro|Haga, Norihiro|Ishida, Hideyuki | ||||||||||
| PMID: | 22783377 | ||||||||||
| 27. | |||||||||||
| Journal: | Hepatogastroenterology. 2013 Mar-Apr;60(122):291-5. | ||||||||||
| Title: | Analysis of the mRNA expression levels of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and orotate phosphoribosyl transferase (OPRT) in liver metastases from colorectal cancer. | ||||||||||
| Author: | Yamane, Takao|Seshimo, Akiyoshi|Kameoka, Shingo | ||||||||||
| PMID: | 22945388 | ||||||||||
| 28. | |||||||||||
| Journal: | Anticancer Drugs. 2013 Jul;24(6):617-22. | ||||||||||
| Title: | Genetic polymorphisms of enzymes related to oral tegafur/uracil therapeutic efficacy in patients with hepatocellular carcinoma. | ||||||||||
| Author: | Fushiya, Nao|Takagi, Ichiro|Nishino, Hirokazu|Akizuki, Setsuko|Ohnishi, Akihiro | ||||||||||
| PMID: | 23571497 | ||||||||||
| 29. | |||||||||||
| Journal: | Onco Targets Ther. 2013 Jul 3;6:811-8. | ||||||||||
| Title: | Clinical significance of the thymidylate synthase, dihydropyrimidine dehydrogenase, and thymidine phosphorylase mRNA expressions in hepatocellular carcinoma patients receiving 5-fluorouracil-based transarterial chemoembolization treatment. | ||||||||||
| Author: | Zhao, Hongyun|Zhao, Yuanyuan|Guo, Ying|Huang, Yan|Lin, Suxia|Xue, Cong|Xu, Fei|Zhang, Yang|Zhao, Liping|Hu, Zhihuang|Zhang, Li | ||||||||||
| PMID: | 23861589 | ||||||||||
| 30. | |||||||||||
| Journal: | J Surg Res. 2015 Apr;194(2):343-50. | ||||||||||
| Title: | Prognostic value of biomarkers in metastatic colorectal cancer patients. | ||||||||||
| Author: | Kataoka, Kozo|Kanazawa, Akiyoshi|Nakajima, Akio|Yamaguchi, Ayane|Arimoto, Akira | ||||||||||
| PMID: | 25456112 | ||||||||||
| 31. | |||||||||||
| Journal: | Int J Mol Sci. 2015 Oct 6;16(10):23668-82. | ||||||||||
| Title: | MicroRNA-302b Enhances the Sensitivity of Hepatocellular Carcinoma Cell Lines to 5-FU via Targeting Mcl-1 and DPYD. | ||||||||||
| Author: | Cai, Donghui|He, Kang|Chang, Su'e|Tong, Dongdong|Huang, Chen | ||||||||||
| PMID: | 26457704 | ||||||||||
| 32. | |||||||||||
| Journal: | Asian J Surg. 2016 Jul;39(3):149-54. | ||||||||||
| Title: | Administration of adjuvant oral tegafur/uracil chemotherapy post hepatocellular carcinoma resection: A randomized controlled trial. | ||||||||||
| Author: | Ishizuka, Mitsuru|Kubota, Keiichi|Nemoto, Takehiko|Shimoda, Mitsugi|Kato, Masato|Iso, Yukihiro|Tago, Kazuma | ||||||||||
| PMID: | 26123137 | ||||||||||
| 33. | |||||||||||
| Journal: | Contemp Oncol (Pozn). 2017;21(1):16-20. | ||||||||||
| Title: | S-1 for treatment of advanced hepatocellular carcinoma: a systematic review of the literature. | ||||||||||
| Author: | Huang, Wu-Kui|You, Li-Na|Yang, Shu-Fa|Liu, Deng-Yao|Liu, Mo|Fan, Xi-Wen | ||||||||||
| PMID: | 28435393 | ||||||||||
| 34. | |||||||||||
| Journal: | Oncol Lett. 2017 Jul;14(1):930-936. | ||||||||||
| Title: | Elevated levels of mRNAs encoding dihydropyrimidine dehydrogenase and thymidylate synthase are associated with improved survival of patients with hepatocellular carcinoma treated with S-1. | ||||||||||
| Author: | Okano, Yusuke|Kuramochi, Hidekazu|Nakajima, Go|Katagiri, Satoshi|Yamamoto, Masakazu | ||||||||||
| PMID: | 28693254 | ||||||||||
| 35. | |||||||||||
| Journal: | Cell Death Dis. 2018 Jan 22;9(2):69. | ||||||||||
| Title: | Dihydropyrimidine dehydrogenase predicts survival and response to interferon-alpha in hepatocellular carcinoma. | ||||||||||
| Author: | Zhu, Wei-Ping|Liu, Ze-Yang|Zhao, Yi-Ming|He, Xi-Gan|Pan, Qi|Zhang, Ning|Zhou, Jia-Min|Wang, Long-Rong|Wang, Miao|Zhan, Di-Hua|Ma, De-Ning|Wang, Lu | ||||||||||
| PMID: | 29358721 | ||||||||||
| 36. | |||||||||||
| Journal: | Oncol Lett. 2018 May;15(5):7175-7181. | ||||||||||
| Title: | Pharmacokinetics of continuous transarterial infusion of 5-fluorouracil in patients with advanced hepatocellular carcinoma. | ||||||||||
| Author: | Gao, Jian|Zhen, Rui|Liao, Hai|Zhuang, Wenquan|Guo, Wenbo | ||||||||||
| PMID: | 29725440 | ||||||||||