Primary Site >> Liver Cancer
Gene >> DPYD
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Ref: Dihydropyrimidine dehydrogenase activity in hepatocellular carcinoma: implication in 5-fluorouracil-based chemotherapy. PMID: 9815697 |
Ref: Expression levels of thymidine phosphorylase and dihydropyrimidine dehydrogenase in various human tumor tissues. PMID: 10853015 Ref: [Clinical significance of determinations of dihydropyrimidine dehydrogenase levels in primary and hepatic lesions of colorectal cancer patients]. PMID: 11086435 |
Ref: Dihydropyrimidine dehydrogenase activity of cancerous and non-cancerous tissues in liver and large intestine. PMID: 11295091 Ref: [Effect of peroral doxifluridine plus hepatic arterial infusion for synchronous liver metastasis of colorectal cancer--correlation with the expression of thymidine phosphorylase and dihydropyrimidine dehydrogenase in primary colorectal cancer lesions]. PMID: 11707995 |
Ref: [A case of liver metastasis of rectal cancer demonstrating complete response to 5-FU + Leucovorin + UFT]. PMID: 11977552 Ref: Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase. PMID: 12084458 |
Ref: Dihydropyrimidine dehydrogenase and thymidylate synthase activities in hepatocellular carcinomas and in diseased livers. PMID: 13680162 |
Ref: The efficacy of the combination therapy of 5-fluorouracil, cisplatin and leucovorin for hepatocellular carcinoma and its predictable factors. PMID: 14689231 Ref: Thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in hepatocellular carcinoma and metastatic liver cancer. PMID: 15254700 Ref: [Influence on 5-fluorouracil metabolism by combination of interferon-alpha and 5-fluorouracil against human hepatocellular carcinoma xenografts]. PMID: 15508442 |
Ref: Consensus interferon enhances the anti-proliferative effect of 5-fluorouracil on human hepatoma cells via downregulation of dihydropyrimidine dehydrogenase expression. PMID: 15698412 Ref: Immunohistochemical demonstration of fluoropyrimidine-metabolizing enzymes in various types of cancer. PMID: 16211289 |
Ref: Correlation between chemosensitivity and mRNA expression level of 5-fluorouracil-related metabolic enzymes during liver metastasis of colorectal cancer. PMID: 16525674 |
Ref: [Anti-tumor effects of various interferons-alpha +5-fluorouracil via downregulation of dihydropyrimidine dehydrogenase in hepatoma cells]. PMID: 17565266 Ref: Alteration of dihydropyrimidine dehydrogenase expression by IFN-alpha affects the antiproliferative effects of 5-fluorouracil in human hepatocellular carcinoma cells. PMID: 17699726 Ref: Profiling of fluorouracil-related genes by microdissection technique in hepatocellular carcinoma. PMID: 18019677 Ref: Gene expression of 5-fluorouracil metabolic enzymes in hepatocellular carcinoma and non-tumor tissue. PMID: 18230555 |
Ref: Significance of dihydropyrimidine dehydrogenase and thymidylate synthase mRNA expressions in hepatocellular carcinoma. PMID: 19054147 Ref: Phase II study of UFT with leucovorin plus hepatic arterial infusion with irinotecan, 5-fluorouracil and leucovorin for non-resectable liver metastases of colorectal cancer. PMID: 19077422 Ref: Identification of genes conferring resistance to 5-fluorouracil. PMID: 19622726 |
Ref: Synergistic effect of 5-fluorouracil and the flavanoid oroxylin A on HepG2 human hepatocellular carcinoma and on H22 transplanted mice. PMID: 19585117 Ref: Combination chemotherapy with S-1 and platinum in advanced hepatocellular carcinoma. PMID: 21187521 |
Ref: The cancer stem cell marker CD133 is a predictor of the effectiveness of S1+ pegylated interferon alpha-2b therapy against advanced hepatocellular carcinoma. PMID: 20683621 Ref: Hepatic fibrosis does not affect the pharmacokinetics of 5-fluorouracil in rats. PMID: 21341281 |
Ref: Thymidylate synthase and thymidine phosphorylase mRNA expression in primary lesions using laser capture microdissection is useful for prediction of the efficacy of FOLFOX treatment in colorectal cancer patients with liver metastasis. PMID: 22783377 |
Ref: Analysis of the mRNA expression levels of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and orotate phosphoribosyl transferase (OPRT) in liver metastases from colorectal cancer. PMID: 22945388 Ref: Genetic polymorphisms of enzymes related to oral tegafur/uracil therapeutic efficacy in patients with hepatocellular carcinoma. PMID: 23571497 Ref: Clinical significance of the thymidylate synthase, dihydropyrimidine dehydrogenase, and thymidine phosphorylase mRNA expressions in hepatocellular carcinoma patients receiving 5-fluorouracil-based transarterial chemoembolization treatment. PMID: 23861589 |
Ref: Prognostic value of biomarkers in metastatic colorectal cancer patients. PMID: 25456112 Ref: MicroRNA-302b Enhances the Sensitivity of Hepatocellular Carcinoma Cell Lines to 5-FU via Targeting Mcl-1 and DPYD. PMID: 26457704 |
Ref: Administration of adjuvant oral tegafur/uracil chemotherapy post hepatocellular carcinoma resection: A randomized controlled trial. PMID: 26123137 |
Ref: S-1 for treatment of advanced hepatocellular carcinoma: a systematic review of the literature. PMID: 28435393 Ref: Elevated levels of mRNAs encoding dihydropyrimidine dehydrogenase and thymidylate synthase are associated with improved survival of patients with hepatocellular carcinoma treated with S-1. PMID: 28693254 |
Ref: Dihydropyrimidine dehydrogenase predicts survival and response to interferon-alpha in hepatocellular carcinoma. PMID: 29358721 Ref: Pharmacokinetics of continuous transarterial infusion of 5-fluorouracil in patients with advanced hepatocellular carcinoma. PMID: 29725440 |