Primary Site >> Liver Cancer
Gene >> DNMT3A
| 1. | |||||||||||
| Journal: | Hepatology. 2001 Mar;33(3):561-8. | ||||||||||
| Title: | Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis. | ||||||||||
| Author: | Saito, Y|Kanai, Y|Sakamoto, M|Saito, H|Ishii, H|Hirohashi, S | ||||||||||
| PMID: | 11230735 | ||||||||||
| 2. | |||||||||||
| Journal: | J Biol Chem. 2002 May 3;277(18):16048-58. | ||||||||||
| Title: | Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma. | ||||||||||
| Author: | Majumder, Sarmila|Ghoshal, Kalpana|Datta, Jharna|Bai, Shoumei|Dong, Xiaocheng|Quan, Ning|Plass, Christoph|Jacob, Samson T | ||||||||||
| PMID: | 11844796 | ||||||||||
| 3. | |||||||||||
| Journal: | Hepatol Res. 2003 Jul;26(3):186-191. | ||||||||||
| Title: | Expression of DNA (5-cytosin)-methyltransferases (DNMTs) in hepatocellular carcinomas. | ||||||||||
| Author: | Nagai, Maho|Nakamura, Akihiro|Makino, Reiko|Mitamura, Keiji | ||||||||||
| PMID: | 12850690 | ||||||||||
| 4. | |||||||||||
| Journal: | Cancer Lett. 2006 Feb 28;233(2):271-8. | ||||||||||
| Title: | DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma. | ||||||||||
| Author: | Park, Hye-Jung|Yu, Eunsil|Shim, Yhong-Hee | ||||||||||
| PMID: | 15885882 | ||||||||||
| 5. | |||||||||||
| Journal: | Int J Mol Med. 2007 Jul;20(1):65-73. | ||||||||||
| Title: | DNA methyltransferase expression and DNA methylation in human hepatocellular carcinoma and their clinicopathological correlation. | ||||||||||
| Author: | Oh, Bong-Kyeong|Kim, Haeryoung|Park, Hye-Jung|Shim, Yhong-Hee|Choi, Jinsub|Park, Chanil|Park, Young Nyun | ||||||||||
| PMID: | 17549390 | ||||||||||
| 6. | |||||||||||
| Journal: | J Hepatol. 2009 Feb;50(2):377-87. | ||||||||||
| Title: | Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A. | ||||||||||
| Author: | Zheng, Da-Li|Zhang, Li|Cheng, Na|Xu, Xiao|Deng, Qing|Teng, Xiao-Mei|Wang, Ke-Sheng|Zhang, Xin|Huang, Jian|Han, Ze-Guang | ||||||||||
| PMID: | 19070387 | ||||||||||
| 7. | |||||||||||
| Journal: | Toxicol Sci. 2009 Jun;109(2):193-205. | ||||||||||
| Title: | Phenobarbital elicits unique, early changes in the expression of hepatic genes that affect critical pathways in tumor-prone B6C3F1 mice. | ||||||||||
| Author: | Phillips, Jennifer M|Burgoon, Lyle D|Goodman, Jay I | ||||||||||
| PMID: | 19270015 | ||||||||||
| 8. | |||||||||||
| Journal: | Toxicol Sci. 2009 Aug;110(2):319-33. | ||||||||||
| Title: | The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumors. | ||||||||||
| Author: | Phillips, Jennifer M|Burgoon, Lyle D|Goodman, Jay I | ||||||||||
| PMID: | 19482888 | ||||||||||
| 9. | |||||||||||
| Journal: | J Viral Hepat. 2010 Feb 1;17(2):98-107. | ||||||||||
| Title: | Hepatitis B virus X protein induces hypermethylation of p16(INK4A) promoter via DNA methyltransferases in the early stage of HBV-associated hepatocarcinogenesis. | ||||||||||
| Author: | Zhu, Y-Z|Zhu, R|Fan, J|Pan, Q|Li, H|Chen, Q|Zhu, H-G | ||||||||||
| PMID: | 19732323 | ||||||||||
| 10. | |||||||||||
| Journal: | Gastroenterology. 2010 May;138(5):1898-908. | ||||||||||
| Title: | Functional switching of TGF-beta1 signaling in liver cancer via epigenetic modulation of a single CpG site in TTP promoter. | ||||||||||
| Author: | Sohn, Bo Hwa|Park, In Young|Lee, Jung Ju|Yang, Suk-Jin|Jang, Ye Jin|Park, Kyung Chan|Kim, Dong Joon|Lee, Dong Chul|Sohn, Hyun Ahm|Kim, Tae Woo|Yoo, Hyang-Sook|Choi, Jong Young|Bae, Yun Soo|Yeom, Young Il | ||||||||||
| PMID: | 20038433 | ||||||||||
| 11. | |||||||||||
| Journal: | J Biomed Biotechnol. 2010;2010:737535. | ||||||||||
| Title: | Depletion of DNMT3A suppressed cell proliferation and restored PTEN in hepatocellular carcinoma cell. | ||||||||||
| Author: | Zhao, Zhujiang|Wu, Qingxiang|Cheng, Jian|Qiu, Xuemei|Zhang, Jianqiong|Fan, Hong | ||||||||||
| PMID: | 20467490 | ||||||||||
| 12. | |||||||||||
| Journal: | Exp Ther Med. 2010 May;1(3):519-523. | ||||||||||
| Title: | Epigenetic activation of E-cadherin is a candidate therapeutic target in human hepatocellular carcinoma. | ||||||||||
| Author: | Qiu, Xuemei|Qiao, Fengchang|Su, Xianwei|Zhao, Zhujiang|Fan, Hong | ||||||||||
| PMID: | 22993570 | ||||||||||
| 13. | |||||||||||
| Journal: | Exp Ther Med. 2011 Sep;2(5):951-955. | ||||||||||
| Title: | microRNA-450a targets DNA methyltransferase 3a in hepatocellular carcinoma. | ||||||||||
| Author: | Weng, Zhihong|Wang, Dongdong|Zhao, Wenyue|Song, Mengqi|You, Faping|Yang, Lian|Chen, Libo | ||||||||||
| PMID: | 22977604 | ||||||||||
| 14. | |||||||||||
| Journal: | Oncogenesis. 2012 Sep 3;1:e25. | ||||||||||
| Title: | Epigenetic control of metastasis-associated protein 1 gene expression by hepatitis B virus X protein during hepatocarcinogenesis. | ||||||||||
| Author: | Lee, M-H|Na, H|Na, T-Y|Shin, Y-K|Seong, J-K|Lee, M-O | ||||||||||
| PMID: | 23552838 | ||||||||||
| 15. | |||||||||||
| Journal: | Cell Signal. 2013 Feb;25(2):439-46. | ||||||||||
| Title: | miR-101 is down-regulated by the hepatitis B virus x protein and induces aberrant DNA methylation by targeting DNA methyltransferase 3A. | ||||||||||
| Author: | Wei, Xufu|Xiang, Tingxiu|Ren, Guosheng|Tan, Cui|Liu, Rui|Xu, Xiao|Wu, Zhongjun | ||||||||||
| PMID: | 23124077 | ||||||||||
| 16. | |||||||||||
| Journal: | Hepatology. 2013 Sep;58(3):1153-65. | ||||||||||
| Title: | miR-148a plays a pivotal role in the liver by promoting the hepatospecific phenotype and suppressing the invasiveness of transformed cells. | ||||||||||
| Author: | Gailhouste, Luc|Gomez-Santos, Laura|Hagiwara, Keitaro|Hatada, Izuho|Kitagawa, Noriyuki|Kawaharada, Kazushi|Thirion, Muriel|Kosaka, Nobuyoshi|Takahashi, Ryou-U|Shibata, Tatsuhiro|Miyajima, Atsushi|Ochiya, Takahiro | ||||||||||
| PMID: | 23532995 | ||||||||||
| 17. | |||||||||||
| Journal: | Virology. 2013 Jun 20;441(1):57-65. | ||||||||||
| Title: | DNA methyltransferases 1 and 3B are required for hepatitis C virus infection in cell culture. | ||||||||||
| Author: | Chen, Chao|Pan, Dan|Deng, A-Mei|Huang, Fang|Sun, Bin-Lian|Yang, Rong-Ge | ||||||||||
| PMID: | 23545144 | ||||||||||
| 18. | |||||||||||
| Journal: | Free Radic Biol Med. 2013 Dec;65:632-644. | ||||||||||
| Title: | Epigenetic silencing of NAD(P)H:quinone oxidoreductase 1 by hepatitis B virus X protein increases mitochondrial injury and cellular susceptibility to oxidative stress in hepatoma cells. | ||||||||||
| Author: | Wu, Yun-Li|Wang, Dong|Peng, Xian-E|Chen, Yan-Ling|Zheng, Da-Li|Chen, Wan-Nan|Lin, Xu | ||||||||||
| PMID: | 23920313 | ||||||||||
| 19. | |||||||||||
| Journal: | Biomed Rep. 2013 Jul;1(4):664-668. | ||||||||||
| Title: | DNMT3A -448A>G polymorphism and the risk for hepatocellular carcinoma. | ||||||||||
| Author: | Zhao, Chengcheng|Yan, Feng|Wu, Huazhang|Qiao, Fengchang|Qiu, Xuemei|Fan, Hong | ||||||||||
| PMID: | 24649006 | ||||||||||
| 20. | |||||||||||
| Journal: | PLoS One. 2014 Dec 30;9(12):e116179. | ||||||||||
| Title: | Trichloroethylene-induced gene expression and DNA methylation changes in B6C3F1 mouse liver. | ||||||||||
| Author: | Jiang, Yan|Chen, Jiahong|Tong, Jian|Chen, Tao | ||||||||||
| PMID: | 25549359 | ||||||||||
| 21. | |||||||||||
| Journal: | Oncol Rep. 2014 Nov;32(5):2093-103. | ||||||||||
| Title: | DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model. | ||||||||||
| Author: | Valencia Antunez, Carlos Alberto|Taja Chayeb, Lucia|Rodriguez-Segura, Miguel Angel|Lopez Alvarez, Guadalupe Soledad|Garcia-Cuellar, Claudia M|Villa Trevino, Saul | ||||||||||
| PMID: | 25190601 | ||||||||||
| 22. | |||||||||||
| Journal: | Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9555-60. | ||||||||||
| Title: | HBx induces hypomethylation of distal intragenic CpG islands required for active expression of developmental regulators. | ||||||||||
| Author: | Lee, Sun-Min|Lee, Young-gun|Bae, Jae-Bum|Choi, Jung Kyoon|Tayama, Chiharu|Hata, Kenichiro|Yun, Yungdae|Seong, Je-Kyung|Kim, Young-Joon | ||||||||||
| PMID: | 24941955 | ||||||||||
| 23. | |||||||||||
| Journal: | Hepatology. 2014 Sep;60(3):872-83. | ||||||||||
| Title: | Modulation of miR-29 expression by alpha-fetoprotein is linked to the hepatocellular carcinoma epigenome. | ||||||||||
| Author: | Parpart, Sonya|Roessler, Stephanie|Dong, Fei|Rao, Vinay|Takai, Atsushi|Ji, Junfang|Qin, Lun-Xiu|Ye, Qing-Hai|Jia, Hu-Liang|Tang, Zhao-You|Wang, Xin Wei | ||||||||||
| PMID: | 24798303 | ||||||||||
| 24. | |||||||||||
| Journal: | Int J Cancer. 2014 Aug 1;135(3):635-46. | ||||||||||
| Title: | Epigenetic silencing of SFRP1 and SFRP5 by hepatitis B virus X protein enhances hepatoma cell tumorigenicity through Wnt signaling pathway. | ||||||||||
| Author: | Xie, Qing|Chen, Linlin|Shan, Xuefeng|Shan, Xiaoliang|Tang, Jia|Zhou, Fan|Chen, Qingmei|Quan, Huiqin|Nie, Dan|Zhang, Wenlu|Huang, Ai-Long|Tang, Ni | ||||||||||
| PMID: | 24374650 | ||||||||||
| 25. | |||||||||||
| Journal: | Toxicology. 2014 Jan 6;315:65-9. | ||||||||||
| Title: | Fumonisin B1 induces global DNA hypomethylation in HepG2 cells - An alternative mechanism of action. | ||||||||||
| Author: | Chuturgoon, Anil|Phulukdaree, Alisa|Moodley, Devapregasan | ||||||||||
| PMID: | 24280379 | ||||||||||
| 26. | |||||||||||
| Journal: | Zhonghua Zhong Liu Za Zhi. 2014 Feb;36(2):123-7. | ||||||||||
| Title: | [Serum anti-Ku86: a potential biomarker for early detection of hepatocellular carcinoma]. | ||||||||||
| Author: | Chu, Lei|Zhang, Xiajun|Wang, Guozhong|Zhou, Wenjun|Du, Zhongxiang|Liu, Anding|Zhao, Hong | ||||||||||
| PMID: | 24796461 | ||||||||||
| 27. | |||||||||||
| Journal: | Int J Clin Exp Med. 2015 Mar 15;8(3):4175-85. eCollection 2015. | ||||||||||
| Title: | Hepatitis B virus infection in hepatocellular carcinoma tissues upregulates expression of DNA methyltransferases. | ||||||||||
| Author: | Li, Haiping|Yang, Fengmei|Gao, Bo|Yu, Zongtao|Liu, Xiaobo|Xie, Fei|Zhang, Jicai | ||||||||||
| PMID: | 26064328 | ||||||||||
| 28. | |||||||||||
| Journal: | Phytomedicine. 2015 Sep 15;22(10):961-7. | ||||||||||
| Title: | Dendrosomal curcumin increases expression of the long non-coding RNA gene MEG3 via up-regulation of epi-miRs in hepatocellular cancer. | ||||||||||
| Author: | Zamani, Mina|Sadeghizadeh, Majid|Behmanesh, Mehrdad|Najafi, Farhood | ||||||||||
| PMID: | 26321746 | ||||||||||
| 29. | |||||||||||
| Journal: | Tumour Biol. 2016 Jan;37(1):877-85. | ||||||||||
| Title: | Genome-wide profiling of DNA methylation reveals preferred sequences of DNMTs in hepatocellular carcinoma cells. | ||||||||||
| Author: | Fan, Hong|Zhao, Zhujiang|Cheng, Yuchao|Cui, He|Qiao, Fengchang|Wang, Ling|Hu, Jiaojiao|Wu, Huzhang|Song, Wei | ||||||||||
| PMID: | 26254611 | ||||||||||
| 30. | |||||||||||
| Journal: | Mol Med Rep. 2016 Jan;13(1):301-8. | ||||||||||
| Title: | Hepatitis B virus X protein upregulates DNA methyltransferase 3A/3B and enhances SOCS-1CpG island methylation. | ||||||||||
| Author: | Fu, Xiaoyu|Song, Xiaoling|Li, Yanyan|Tan, Deming|Liu, Guozhen | ||||||||||
| PMID: | 26573490 | ||||||||||
| 31. | |||||||||||
| Journal: | Mol Med Rep. 2016 May;13(5):3929-35. | ||||||||||
| Title: | MicroRNA-200b inhibits the proliferation of hepatocellular carcinoma by targeting DNA methyltransferase 3a. | ||||||||||
| Author: | Li, Xing-Yu|Feng, Xing-Zi|Tang, Jian-Zhong|Dong, Kun|Wang, Jun-Feng|Meng, Chun-Cheng|Wang, Jun|Mo, Yi-Wo|Sun, Zhi-Wei | ||||||||||
| PMID: | 26986232 | ||||||||||
| 32. | |||||||||||
| Journal: | Asian Pac J Cancer Prev. 2016;17(S3):219-24. | ||||||||||
| Title: | Evaluation of MiR-34 Family and DNA Methyltransferases 1, 3A, 3B Gene Expression Levels in Hepatocellular Carcinoma Following Treatment with Dendrosomal Nanocurcumin. | ||||||||||
| Author: | Chamani, Fatemeh|Sadeghizadeh, Majid|Masoumi, Mahbobeh|Babashah, Sadegh | ||||||||||
| PMID: | 27165229 | ||||||||||
| 33. | |||||||||||
| Journal: | Sci Rep. 2016 Jun 27;6:28637. | ||||||||||
| Title: | DDX3 Represses Stemness by Epigenetically Modulating Tumor-suppressive miRNAs in Hepatocellular Carcinoma. | ||||||||||
| Author: | Li, Hao-Kang|Mai, Ru-Tsun|Huang, Hsien-Da|Chou, Chih-Hung|Chang, Yi-An|Chang, Yao-Wen|You, Li-Ru|Chen, Chun-Ming|Lee, Yan-Hwa Wu | ||||||||||
| PMID: | 27344963 | ||||||||||
| 34. | |||||||||||
| Journal: | Biomed Pharmacother. 2017 May;89:742-750. | ||||||||||
| Title: | MiR-30b-5p acts as a tumor suppressor, repressing cell proliferation and cell cycle in human hepatocellular carcinoma. | ||||||||||
| Author: | Qin, Xian|Chen, Jing|Wu, Long|Liu, Zhisu | ||||||||||
| PMID: | 28273636 | ||||||||||
| 35. | |||||||||||
| Journal: | Toxicol Appl Pharmacol. 2017 Aug 1;328:34-45. | ||||||||||
| Title: | HMGA2, a driver of inflammation, is associated with hypermethylation in acute liver injury. | ||||||||||
| Author: | Huang, Huimin|Li, Haidi|Chen, Xin|Yang, Yang|Li, Xiaofeng|Li, Wanxia|Huang, Cheng|Meng, Xiaoming|Zhang, Lei|Li, Jun | ||||||||||
| PMID: | 28502886 | ||||||||||
| 36. | |||||||||||
| Journal: | Cell Death Dis. 2017 Mar 16;8(3):e2675. | ||||||||||
| Title: | Bidirectional transcription of Linc00441 and RB1 via H3K27 modification-dependent way promotes hepatocellular carcinoma. | ||||||||||
| Author: | Tang, Junwei|Xie, Yu|Xu, Xiaoliang|Yin, Yin|Jiang, Runqiu|Deng, Lei|Tan, Zhongming|Gangarapu, Venkatanarayana|Tang, Jinhai|Sun, Beicheng | ||||||||||
| PMID: | 28300839 | ||||||||||
| 37. | |||||||||||
| Journal: | Toxicol Appl Pharmacol. 2017 Jan 15;315:35-49. | ||||||||||
| Title: | Methylation of Septin9 mediated by DNMT3a enhances hepatic stellate cells activation and liver fibrogenesis. | ||||||||||
| Author: | Wu, Yuting|Bu, Fangtian|Yu, Haixia|Li, Wanxia|Huang, Cheng|Meng, Xiaoming|Zhang, Lei|Ma, Taotao|Li, Jun | ||||||||||
| PMID: | 27939986 | ||||||||||
| 38. | |||||||||||
| Journal: | Free Radic Res. 2018 Apr;52(4):455-464. | ||||||||||
| Title: | Circulating cell-free DNA of methylated insulin-like growth factor-binding protein 7 predicts a poor prognosis in hepatitis B virus-associated hepatocellular carcinoma after hepatectomy. | ||||||||||
| Author: | Li, Feng|Qiao, Chen-Yang|Gao, Shuai|Fan, Yu-Chen|Chen, Long-Yan|Wang, Kai | ||||||||||
| PMID: | 29463155 | ||||||||||
| 39. | |||||||||||
| Journal: | Toxicol Lett. 2018 Jun 1;289:42-53. | ||||||||||
| Title: | Gene expression network regulated by DNA methylation and microRNA during microcystin-leucine arginine induced malignant transformation in human hepatocyte L02 cells. | ||||||||||
| Author: | Chen, Hong-Qiang|Zhao, Ji|Li, Yan|He, Li-Xiong|Huang, Yu-Jing|Shu, Wei-Qun|Cao, Jia|Liu, Wen-Bin|Liu, Jin-Yi | ||||||||||
| PMID: | 29518473 | ||||||||||
| 40. | |||||||||||
| Journal: | Cell Death Differ. 2018 Mar 19. pii: 10.1038/s41418-018-0095-6. | ||||||||||
| Title: | Epigenetic restriction of Hippo signaling by MORC2 underlies stemness of hepatocellular carcinoma cells. | ||||||||||
| Author: | Wang, Tao|Qin, Zhong-Yi|Wen, Liang-Zhi|Guo, Yan|Liu, Qin|Lei, Zeng-Jie|Pan, Wei|Liu, Kai-Jun|Wang, Xing-Wei|Lai, Shu-Jie|Sun, Wen-Jing|Wei, Yan-Ling|Liu, Lei|Guo, Ling|Chen, Yu-Qin|Wang, Jun|Xiao, Hua-Liang|Bian, Xiu-Wu|Chen, Dong-Feng|Wang, Bin | ||||||||||
| PMID: | 29555977 | ||||||||||
| 41. | |||||||||||
| Journal: | Pathol Res Pract. 2018 Jun;214(6):896-901. | ||||||||||
| Title: | Lower expression of bone marrow miR-122 is an independent risk factor for overall survival in cytogenetically normal acute myeloid leukemia. | ||||||||||
| Author: | Zhang, Ting-Juan|Qian, Zhen|Wen, Xiang-Mei|Zhou, Jing-Dong|Li, Xi-Xi|Xu, Zi-Jun|Ma, Ji-Chun|Zhang, Zhi-Hui|Lin, Jiang|Qian, Jun | ||||||||||
| PMID: | 29627222 | ||||||||||
| 42. | |||||||||||
| Journal: | Sci Transl Med. 2018 Apr 18;10(437). pii: 10/437/eaap9840. | ||||||||||
| Title: | Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target. | ||||||||||
| Author: | Liu, Dabin|Wong, Chi Chun|Fu, Li|Chen, Huarong|Zhao, Liuyang|Li, Chuangen|Zhou, Yunfei|Zhang, Yanquan|Xu, Weiqi|Yang, Yidong|Wu, Bin|Cheng, Gong|Lai, Paul Bo-San|Wong, Nathalie|Sung, Joseph J Y|Yu, Jun | ||||||||||
| PMID: | 29669855 | ||||||||||
| 43. | |||||||||||
| Journal: | Pathol Res Pract. 2018 Jul;214(7):1024-1030. | ||||||||||
| Title: | MiR-876-5p acts as an inhibitor in hepatocellular carcinoma progression by targeting DNMT3A. | ||||||||||
| Author: | Wang, Yizhou|Xie, Yanting|Li, Xifeng|Lin, Jianbo|Zhang, Shichao|Li, Zheng|Huo, Lei|Gong, Renyan | ||||||||||
| PMID: | 29724530 | ||||||||||
| 44. | |||||||||||
| Journal: | Mol Ther Nucleic Acids. 2018 Jun 1;11:23-33. | ||||||||||
| Title: | Epigenetic Targeting of Granulin in Hepatoma Cells by Synthetic CRISPR dCas9 Epi-suppressors. | ||||||||||
| Author: | Wang, Hong|Guo, Rui|Du, Zhonghua|Bai, Ling|Li, Lingyu|Cui, Jiuwei|Li, Wei|Hoffman, Andrew R|Hu, Ji-Fan | ||||||||||
| PMID: | 29858058 | ||||||||||
| 45. | |||||||||||
| Journal: | J Clin Transl Hepatol. 2018 Jun 28;6(2):141-146. | ||||||||||
| Title: | Effect of Genistein in Comparison with Trichostatin A on Reactivation of DNMTs Genes in Hepatocellular Carcinoma. | ||||||||||
| Author: | Sanaei, Masumeh|Kavoosi, Fraidoon|Roustazadeh, Abazar|Golestan, Fatemeh | ||||||||||
| PMID: | 29951358 | ||||||||||