Primary Site >> Liver Cancer

Gene >> DLC1

Journal: Cancer Res. 1998 May 15;58(10):2196-9.
Title: Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP.
Author: Yuan, B Z|Miller, M J|Keck, C L|Zimonjic, D B|Thorgeirsson, S S|Popescu, N C
PMID: 9605766
Journal: Hum Mutat. 2000;15(2):156-65.
Title: Sequence variants of DLC1 in colorectal and ovarian tumours.
Author: Wilson, P J|McGlinn, E|Marsh, A|Evans, T|Arnold, J|Wright, K|Biden, K|Young, J|Wainwright, B|Wicking, C|Chenevix-Trench, G
PMID: 10649492
Journal: Gene. 2002 Apr 17;288(1-2):119-27.
Title: Gene structure, tissue expression, and linkage mapping of the mouse DLC-1 gene (Arhgap7).
Author: Durkin, Marian E|Yuan, Bao-Zhu|Thorgeirsson, Snorri S|Popescu, Nicholas C
PMID: 12034501
Journal: J Biol Chem. 2003 Mar 21;278(12):10824-30.
Title: Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma.
Author: Ching, Yick-Pang|Wong, Chun-Ming|Chan, Shing-Fai|Leung, Thomas Ho-Yin|Ng, David Chi-Heng|Jin, Dong-Yan|Ng, Irene Oi-lin
PMID: 12531887
Journal: Oncogene. 2003 Jun 19;22(25):3943-51.
Title: Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells.
Author: Kim, Tai Young|Jong, Hyun-Soon|Song, Sang-Hyun|Dimtchev, Alexandre|Jeong, Sook-Jung|Lee, Jung Weon|Kim, Tae-You|Kim, Noe Kyeong|Jung, Mira|Bang, Yung-Jue
PMID: 12813468
Journal: Mutat Res. 2003 Jul 25;528(1-2):45-53.
Title: Evaluation of DLC1 as a prostate cancer susceptibility gene: mutation screen and association study.
Author: Zheng, Siqun L|Mychaleckyj, Josyf C|Hawkins, Gregory A|Isaacs, Sarah D|Wiley, Kathy E|Turner, Aubrey|Chang, Bao-li|von Kap-Herr, Chris|Carpten, John D|Pettenati, Mark|Bleecker, Eugene R|Walsh, Patrick C|Trent, Jeffrey M|Meyers, Deborah A|Isaacs, William B
PMID: 12873722
Journal: Cancer Res. 2005 Oct 1;65(19):8861-8.
Title: Rho GTPase-activating protein deleted in liver cancer suppresses cell proliferation and invasion in hepatocellular carcinoma.
Author: Wong, Chun-Ming|Yam, Judy Wai-Ping|Ching, Yick-Pang|Yau, Tai-On|Leung, Thomas Ho-Yin|Jin, Dong-Yan|Ng, Irene Oi-Lin
PMID: 16204057
Journal: J Biol Chem. 2006 Feb 24;281(8):4762-70.
Title: Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells.
Author: Hers, Ingeborg|Wherlock, Matthew|Homma, Yoshimi|Yagisawa, Hitoshi|Tavare, Jeremy M
PMID: 16338927
Journal: Cancer Res. 2006 Sep 1;66(17):8367-72.
Title: Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression.
Author: Yam, Judy Wai Ping|Ko, Frankie Chi Fat|Chan, Chung-Yiu|Jin, Dong-Yan|Ng, Irene Oi-Lin
PMID: 16951145
Journal: Mod Pathol. 2006 Dec;19(12):1546-54.
Title: Positional expression profiling indicates candidate genes in deletion hotspots of hepatocellular carcinoma.
Author: Chan, Kathy Y-Y|Lai, Paul B-S|Squire, Jeremy A|Beheshti, Ben|Wong, Navy L-Y|Sy, Shirley M-H|Wong, Nathalie
PMID: 16980951
Journal: Int J Oncol. 2006 Nov;29(5):1127-32.
Title: Expression profile of the tumor suppressor genes DLC-1 and DLC-2 in solid tumors.
Author: Ullmannova, Veronika|Popescu, Nicholas C
PMID: 17016643
Journal: Proc Natl Acad Sci U S A. 2007 May 22;104(21):9012-7.
Title: Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities.
Author: Qian, Xiaolan|Li, Guorong|Asmussen, Holly K|Asnaghi, Laura|Vass, William C|Braverman, Richard|Yamada, Kenneth M|Popescu, Nicholas C|Papageorge, Alex G|Lowy, Douglas R
PMID: 17517630
Journal: Int J Oncol. 2008 Jun;32(6):1285-91.
Title: DLC1 suppresses distant dissemination of human hepatocellular carcinoma cells in nude mice through reduction of RhoA GTPase activity, actin cytoskeletal disruption and down-regulation of genes involved in metastasis.
Author: Zhou, Xiaoling|Zimonjic, Drazen B|Park, Sang-Won|Yang, Xu-Yu|Durkin, Marian E|Popescu, Nicholas C
PMID: 18497990
Journal: PLoS One. 2008 Jul 23;3(7):e2779.
Title: Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma.
Author: Wong, Carmen Chak-Lui|Wong, Chun-Ming|Ko, Frankie Chi-Fat|Chan, Lo-Kong|Ching, Yick-Pang|Yam, Judy Wai-Ping|Ng, Irene Oi-lin
PMID: 18648664
Journal: Genes Dev. 2008 Jun 1;22(11):1439-44.
Title: DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma.
Author: Xue, Wen|Krasnitz, Alexander|Lucito, Robert|Sordella, Raffaella|Vanaelst, Linda|Cordon-Cardo, Carlos|Singer, Stephan|Kuehnel, Florian|Wigler, Michael|Powers, Scott|Zender, Lars|Lowe, Scott W
PMID: 18519636
Journal: PLoS One. 2009;4(5):e5572.
Title: Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for Tensin2 PTB domain interaction and is required for tumor-suppressive function.
Author: Chan, Lo-Kong|Ko, Frankie Chi Fat|Ng, Irene Oi-Lin|Yam, Judy Wai Ping
PMID: 19440389
Journal: PLoS One. 2009 Aug 10;4(8):e6566.
Title: Deleted in liver cancer 2 (DLC2) was dispensable for development and its deficiency did not aggravate hepatocarcinogenesis.
Author: Yau, Tai On|Leung, Thomas Ho Yin|Lam, Sandra|Cheung, Oi Fung|Tung, Edmund Kwok Kwan|Khong, Pek Lan|Lam, Amy|Chung, Sookja|Ng, Irene Oi Lin
PMID: 19668331
Journal: Cancer Epidemiol. 2009 Oct;33(3-4):265-70.
Title: Association of DLC1 gene polymorphism with susceptibility to hepatocellular carcinoma in Chinese hepatitis B virus carriers.
Author: Dong, Xiaoqun|Zhou, Gangqiao|Zhai, Yun|Zhang, Hongxing|Yang, Hao|Zhi, Lianteng|Zhang, Xiumei|Chu, Jiayou|He, Fuchu
PMID: 19766077
Journal: Liver Int. 2010 Jan;30(1):139-48.
Title: Deleted in liver cancer 1 isoforms are distinctly expressed in human tissues, functionally different and under differential transcriptional regulation in hepatocellular carcinoma.
Author: Ko, Frankie Chi Fat|Yeung, Yin-Shan|Wong, Chun-Ming|Chan, Lo-Kong|Poon, Ronnie Tung Ping|Ng, Irene Oi-Lin|Yam, Judy Wai Ping
PMID: 19874489
Journal: Gastroenterology. 2010 Oct;139(4):1397-407.
Title: Akt phosphorylation of deleted in liver cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis.
Author: Ko, Frankie Chi Fat|Chan, Lo-Kong|Tung, Edmund Kwok-Kwan|Lowe, Scott W|Ng, Irene Oi-Lin|Yam, Judy Wai Ping
PMID: 20600027
Journal: Gastroenterology. 2010 Oct;139(4):1093-6.
Title: DLC1 and liver cancer: the Akt connection.
Author: Wuestefeld, Torsten|Zender, Lars
PMID: 20800109
Journal: Oncol Lett. 2011 Sep 1;2(5):763-768.
Title: Deleted in liver cancer protein family in human malignancies (Review).
Author: Lukasik, D|Wilczek, E|Wasiutynski, A|Gornicka, B
PMID: 22866123
Journal: Int J Mol Sci. 2011;12(12):8489-501.
Title: Pilot study: alteration of deleted in liver cancer1 and phosphorylated focal adhesion kinase Y397 cytoplasmic expression and the prognostic value in advanced epithelial ovarian carcinoma.
Author: Fan, Dong-Mei|Shi, Hui-Rong
PMID: 22272086
Journal: PLoS One. 2011;6(9):e25547.
Title: Nuclear-targeted deleted in liver cancer 1 (DLC1) is less efficient in exerting its tumor suppressive activity both in vitro and in vivo.
Author: Chan, Lo-Kong|Ko, Frankie Chi Fat|Sze, Karen Man-Fong|Ng, Irene Oi-Lin|Yam, Judy Wai Ping
PMID: 21966542
Journal: Oncol Rep. 2011 Jun;25(6):1739-46.
Title: Ursodeoxycholic acid-induced inhibition of DLC1 protein degradation leads to suppression of hepatocellular carcinoma cell growth.
Author: Chung, Goh Eun|Yoon, Jung-Hwan|Lee, Jeong-Hoon|Kim, Hwi Young|Myung, Sun Jung|Yu, Su Jong|Lee, Sung-Hee|Lee, Soo-Mi|Kim, Yoon Jun|Lee, Hyo-Suk
PMID: 21455586
Journal: Biochem Biophys Res Commun. 2011 Jan 7;404(1):279-83.
Title: The intracellular stability of DLC1 is regulated by the 26S proteasome in human hepatocellular carcinoma cell line Hep3B.
Author: Luo, Hong-wei|Luo, Qiu-ping|Yuan, Ying|Zhu, Xiao-ying|Huang, Shi-feng|Peng, Zhi|Li, Chun-li|Huang, Zong-gan|Feng, Wen-li
PMID: 21130076
Journal: J Hepatol. 2011 Dec;55(6):1400-8.
Title: Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway.
Author: Kudo, Yotaro|Tanaka, Yasuo|Tateishi, Keisuke|Yamamoto, Keisuke|Yamamoto, Shinzo|Mohri, Dai|Isomura, Yoshihiro|Seto, Motoko|Nakagawa, Hayato|Asaoka, Yoshinari|Tada, Motohisa|Ohta, Miki|Ijichi, Hideaki|Hirata, Yoshihiro|Otsuka, Motoyuki|Ikenoue, Tsuneo|Maed
PMID: 21703185
Journal: Mod Pathol. 2012 Jan;25(1):14-25.
Title: Loss of DLC1 is an independent prognostic factor in patients with oral squamous cell carcinoma.
Author: Tripathi, Satyendra Chandra|Kaur, Jatinder|Matta, Ajay|Gao, Xin|Sun, Bin|Chauhan, Shyam Singh|Thakar, Alok|Shukla, Nootan Kumar|Duggal, Ritu|Choudhary, Ajoy Roy|DattaGupta, Siddhartha|Sharma, Mehar Chand|Ralhan, Ranju|Siu, K W Michael
PMID: 22002576
Journal: Oncogene. 2012 Aug 30;31(35):3913-23.
Title: The transcriptional coactivators megakaryoblastic leukemia 1/2 mediate the effects of loss of the tumor suppressor deleted in liver cancer 1.
Author: Muehlich, S|Hampl, V|Khalid, S|Singer, S|Frank, N|Breuhahn, K|Gudermann, T|Prywes, R
PMID: 22139079
Journal: Gastroenterology. 2012 Apr;142(4):957-966.e12.
Title: Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival.
Author: Roessler, Stephanie|Long, Ezhou Lori|Budhu, Anuradha|Chen, Yidong|Zhao, Xuelian|Ji, Junfang|Walker, Robert|Jia, Hu-Liang|Ye, Qing-Hai|Qin, Lun-Xiu|Tang, Zhao-You|He, Ping|Hunter, Kent W|Thorgeirsson, Snorri S|Meltzer, Paul S|Wang, Xin Wei
PMID: 22202459
Journal: Biochem Biophys Res Commun. 2012 Apr 6;420(2):325-30.
Title: Preclinical evaluation of combined antineoplastic effect of DLC1 tumor suppressor protein and suberoylanilide hydroxamic acid on prostate cancer cells.
Author: Zhou, Xiaoling|Yang, Xu-Yu|Popescu, Nicholas C
PMID: 22425986
Journal: Int J Oncol. 2012 Aug;41(2):393-406.
Title: Role of DLC1 tumor suppressor gene and MYC oncogene in pathogenesis of human hepatocellular carcinoma: potential prospects for combined targeted therapeutics (review).
Author: Zimonjic, Drazen B|Popescu, Nicholas C
PMID: 22580498
Journal: J Biol Chem. 2012 Jul 27;287(31):26104-14.
Title: Solution structure of the phosphotyrosine binding (PTB) domain of human tensin2 protein in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode.
Author: Chen, Lihong|Liu, Changdong|Ko, Frankie Chi Fat|Xu, Naining|Ng, Irene Oi-Lin|Yam, Judy Wai Ping|Zhu, Guang
PMID: 22645138
Journal: PLoS One. 2012;7(7):e40302.
Title: The role of Dlc1 isoform 2 in K-Ras2(G12D) induced thymic cancer.
Author: Sabbir, Mohammad Golam|Prieditis, Heather|Ravinsky, Esther|Mowat, Michael R A
PMID: 22792269
Journal: Nat Commun. 2013;4:1618.
Title: PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis.
Author: Ko, Frankie Chi Fat|Chan, Lo-Kong|Sze, Karen Man-Fong|Yeung, Yin-Shan|Tse, Edith Yuk-Ting|Lu, Ping|Yu, Ming-Hua|Ng, Irene Oi-Lin|Yam, Judy Wai Ping
PMID: 23511482
Journal: PLoS One. 2013 Jun 27;8(6):e68226.
Title: EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers.
Author: Au, Sandy Leung-Kuen|Wong, Carmen Chak-Lui|Lee, Joyce Man-Fong|Wong, Chun-Ming|Ng, Irene Oi-Lin
PMID: 23826380
Journal: EMBO Mol Med. 2013 Sep;5(9):1367-82.
Title: Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence.
Author: Hampl, Veronika|Martin, Claudia|Aigner, Achim|Hoebel, Sabrina|Singer, Stephan|Frank, Natalie|Sarikas, Antonio|Ebert, Oliver|Prywes, Ron|Gudermann, Thomas|Muehlich, Susanne
PMID: 23853104
Journal: Oncol Lett. 2014 Aug;8(2):785-788.
Title: Deleted in liver cancer 1 expression and localization in hepatocellular carcinoma tissue sections.
Author: Wolosz, Dominika|Walczak, Agnieszka|Wilczynski, Grzegorz M|Szparecki, Grzegorz|Wilczek, Ewa|Gornicka, Barbara
PMID: 25013499
Journal: J Biol Chem. 2014 Mar 7;289(10):6839-49.
Title: Functional cross-talk between ras and rho pathways: a Ras-specific GTPase-activating protein (p120RasGAP) competitively inhibits the RhoGAP activity of deleted in liver cancer (DLC) tumor suppressor by masking the catalytic arginine finger.
Author: Jaiswal, Mamta|Dvorsky, Radovan|Amin, Ehsan|Risse, Sarah L|Fansa, Eyad K|Zhang, Si-Cai|Taha, Mohamed S|Gauhar, Aziz R|Nakhaei-Rad, Saeideh|Kordes, Claus|Koessmeier, Katja T|Cirstea, Ion C|Olayioye, Monilola A|Haussinger, Dieter|Ahmadian, Mohammad R
PMID: 24443565
Journal: Int J Oncol. 2015 Feb;46(2):782-90.
Title: Mechanistic and biological significance of DNA methyltransferase 1 upregulated by growth factors in human hepatocellular carcinoma.
Author: Fang, Qin-Liang|Yin, Yi-Rui|Xie, Cheng-Rong|Zhang, Sheng|Zhao, Wen-Xiu|Pan, Chao|Wang, Xiao-Min|Yin, Zhen-Yu
PMID: 25420499
Journal: Mol Med Rep. 2015 Sep;12(3):4203-4209.
Title: Significance of genetic variants in DLC1 and their association with hepatocellular carcinoma.
Author: Xie, Cheng-Rong|Sun, Hong-Guang|Sun, Yu|Zhao, Wen-Xiu|Zhang, Sheng|Wang, Xiao-Min|Yin, Zhen-Yu
PMID: 26095787
Journal: Diagn Pathol. 2016 Feb 4;11:19.
Title: DLC-1 is an independent prognostic marker and potential therapeutic target in hepatocellular cancer.
Author: Song, L J|Liu, Q|Meng, X R|Li, Sh L|Wang, L X|Fan, Q X|Xuan, X Y
PMID: 26846339
Journal: Mol Med Rep. 2016 May;13(5):4095-100.
Title: rs621554 single nucleotide polymorphism of DLC1 is associated with breast cancer susceptibility and prognosis.
Author: Ding, Xia|Gao, Sumei|Yang, Qifeng
PMID: 26986853
Journal: Oncotarget. 2016 Jul 19;7(29):45144-45157.
Title: DLC1 is the principal biologically-relevant down-regulated DLC family member in several cancers.
Author: Wang, Dunrui|Qian, Xiaolan|Rajaram, Megha|Durkin, Marian E|Lowy, Douglas R
PMID: 27174913
Journal: Oncol Lett. 2016 Aug;12(2):1591-1596.
Title: Cooperative antiproliferative effect of coordinated ectopic expression of DLC1 tumor suppressor protein and silencing of MYC oncogene expression in liver cancer cells: Therapeutic implications.
Author: Yang, Xuyu|Zhou, Xiaoling|Tone, Paul|Durkin, Marian E|Popescu, Nicholas C
PMID: 27446476
Journal: Oncotarget. 2016 Dec 6;7(49):81255-81267.
Title: Meta-analysis of DNA methylation biomarkers in hepatocellular carcinoma.
Author: Zhang, Cheng|Li, Jinyun|Huang, Tao|Duan, Shiwei|Dai, Dongjun|Jiang, Danjie|Sui, Xinbing|Li, Da|Chen, Yidan|Ding, Fei|Huang, Changxin|Chen, Gongying|Wang, Kaifeng
PMID: 27835605
Journal: PLoS One. 2017 Mar 30;12(3):e0174761.
Title: Regulation of white and brown adipocyte differentiation by RhoGAP DLC1.
Author: Sim, Choon Kiat|Kim, Sun-Yee|Brunmeir, Reinhard|Zhang, Qiongyi|Li, Hongyu|Dharmasegaran, Dharmini|Leong, Carol|Lim, Ying Yan|Han, Weiping|Xu, Feng
PMID: 28358928
Journal: Oncotarget. 2017 Jul 15;8(33):55422-55434.
Title: Resveratrol inhibits age-dependent spontaneous tumorigenesis by SIRT1-mediated post-translational modulations in the annual fish Nothobranchius guentheri.
Author: Liu, Tingting|Ma, Long|Zheng, Zhaodi|Li, Fenglin|Liu, Shan|Xie, Yingbo|Li, Guorong
PMID: 28903430
Journal: Am J Transl Res. 2017 Sep 15;9(9):3904-3917. eCollection 2017.
Title: Comprehensive analysis of long non-coding RNA PVT1 gene interaction regulatory network in hepatocellular carcinoma using gene microarray and bioinformatics.
Author: Zhang, Yu|Dang, Yi-Wu|Wang, Xiao|Yang, Xia|Zhang, Rui|Lv, Zi-Li|Chen, Gang
PMID: 28979669
Journal: Nat Commun. 2017 Oct 30;8(1):1185.
Title: Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration.
Author: Liu, Jessica Aijia|Rao, Yanxia|Cheung, May Pui Lai|Hui, Man-Ning|Wu, Ming-Hoi|Chan, Lo-Kong|Ng, Irene Oi-Lin|Niu, Ben|Cheah, Kathryn S E|Sharma, Rakesh|Hodgson, Louis|Cheung, Martin
PMID: 29084958
Journal: Lab Invest. 2018 Aug;98(8):1014-1024.
Title: The tumor suppressor DLC1 inhibits cancer progression and oncogenic autophagy in hepatocellular carcinoma.
Author: Wu, Hui-Ta|Xie, Cheng-Rong|Lv, Jie|Qi, He-Qiang|Wang, Fei|Zhang, Sheng|Fang, Qin-Liang|Wang, Fu-Qiang|Lu, Yu-Yan|Yin, Zhen-Yu
PMID: 29785050
Journal: Int J Cancer. 2018 Oct 5.
Title: PNPLA3 and TM6SF2 variants as risk factors of hepatocellular carcinoma across various etiologies and severity of underlying liver diseases.
Author: Yang, Jie|Trepo, Eric|Nahon, Pierre|Cao, Qian|Moreno, Christophe|Letouze, Eric|Imbeaud, Sandrine|Gustot, Thierry|Deviere, Jacques|Debette, Stephanie|Amouyel, Philippe|Bioulac-Sage, Paulette|Calderaro, Julien|Ganne-Carrie, Nathalie|Laurent, Alexis|Blanc, J
PMID: 30289982