Primary Site >> Liver Cancer
Gene >> DLC1
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Ref: Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP. PMID: 9605766 |
Ref: Sequence variants of DLC1 in colorectal and ovarian tumours. PMID: 10649492 |
Ref: Gene structure, tissue expression, and linkage mapping of the mouse DLC-1 gene (Arhgap7). PMID: 12034501 |
Ref: Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma. PMID: 12531887 Ref: Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells. PMID: 12813468 Ref: Evaluation of DLC1 as a prostate cancer susceptibility gene: mutation screen and association study. PMID: 12873722 |
Ref: Rho GTPase-activating protein deleted in liver cancer suppresses cell proliferation and invasion in hepatocellular carcinoma. PMID: 16204057 |
Ref: Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells. PMID: 16338927 Ref: Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression. PMID: 16951145 Ref: Positional expression profiling indicates candidate genes in deletion hotspots of hepatocellular carcinoma. PMID: 16980951 Ref: Expression profile of the tumor suppressor genes DLC-1 and DLC-2 in solid tumors. PMID: 17016643 |
Ref: Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities. PMID: 17517630 |
Ref: DLC1 suppresses distant dissemination of human hepatocellular carcinoma cells in nude mice through reduction of RhoA GTPase activity, actin cytoskeletal disruption and down-regulation of genes involved in metastasis. PMID: 18497990 Ref: DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma. PMID: 18519636 Ref: Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma. PMID: 18648664 |
Ref: Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for Tensin2 PTB domain interaction and is required for tumor-suppressive function. PMID: 19440389 Ref: Deleted in liver cancer 2 (DLC2) was dispensable for development and its deficiency did not aggravate hepatocarcinogenesis. PMID: 19668331 Ref: Association of DLC1 gene polymorphism with susceptibility to hepatocellular carcinoma in Chinese hepatitis B virus carriers. PMID: 19766077 |
Ref: Deleted in liver cancer 1 isoforms are distinctly expressed in human tissues, functionally different and under differential transcriptional regulation in hepatocellular carcinoma. PMID: 19874489 Ref: Akt phosphorylation of deleted in liver cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis. PMID: 20600027 Ref: DLC1 and liver cancer: the Akt connection. PMID: 20800109 |
Ref: The intracellular stability of DLC1 is regulated by the 26S proteasome in human hepatocellular carcinoma cell line Hep3B. PMID: 21130076 Ref: Ursodeoxycholic acid-induced inhibition of DLC1 protein degradation leads to suppression of hepatocellular carcinoma cell growth. PMID: 21455586 Ref: Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway. PMID: 21703185 Ref: Nuclear-targeted deleted in liver cancer 1 (DLC1) is less efficient in exerting its tumor suppressive activity both in vitro and in vivo. PMID: 21966542 Ref: Pilot study: alteration of deleted in liver cancer1 and phosphorylated focal adhesion kinase Y397 cytoplasmic expression and the prognostic value in advanced epithelial ovarian carcinoma. PMID: 22272086 Ref: Deleted in liver cancer protein family in human malignancies (Review). PMID: 22866123 |
Ref: Loss of DLC1 is an independent prognostic factor in patients with oral squamous cell carcinoma. PMID: 22002576 Ref: The transcriptional coactivators megakaryoblastic leukemia 1/2 mediate the effects of loss of the tumor suppressor deleted in liver cancer 1. PMID: 22139079 Ref: Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival. PMID: 22202459 Ref: Preclinical evaluation of combined antineoplastic effect of DLC1 tumor suppressor protein and suberoylanilide hydroxamic acid on prostate cancer cells. PMID: 22425986 Ref: Role of DLC1 tumor suppressor gene and MYC oncogene in pathogenesis of human hepatocellular carcinoma: potential prospects for combined targeted therapeutics (review). PMID: 22580498 Ref: Solution structure of the phosphotyrosine binding (PTB) domain of human tensin2 protein in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode. PMID: 22645138 Ref: The role of Dlc1 isoform 2 in K-Ras2(G12D) induced thymic cancer. PMID: 22792269 |
Ref: PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis. PMID: 23511482 Ref: EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers. PMID: 23826380 Ref: Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence. PMID: 23853104 |
Ref: Functional cross-talk between ras and rho pathways: a Ras-specific GTPase-activating protein (p120RasGAP) competitively inhibits the RhoGAP activity of deleted in liver cancer (DLC) tumor suppressor by masking the catalytic arginine finger. PMID: 24443565 Ref: Deleted in liver cancer 1 expression and localization in hepatocellular carcinoma tissue sections. PMID: 25013499 |
Ref: Mechanistic and biological significance of DNA methyltransferase 1 upregulated by growth factors in human hepatocellular carcinoma. PMID: 25420499 Ref: Significance of genetic variants in DLC1 and their association with hepatocellular carcinoma. PMID: 26095787 |
Ref: DLC-1 is an independent prognostic marker and potential therapeutic target in hepatocellular cancer. PMID: 26846339 Ref: rs621554 single nucleotide polymorphism of DLC1 is associated with breast cancer susceptibility and prognosis. PMID: 26986853 Ref: DLC1 is the principal biologically-relevant down-regulated DLC family member in several cancers. PMID: 27174913 Ref: Cooperative antiproliferative effect of coordinated ectopic expression of DLC1 tumor suppressor protein and silencing of MYC oncogene expression in liver cancer cells: Therapeutic implications. PMID: 27446476 Ref: Meta-analysis of DNA methylation biomarkers in hepatocellular carcinoma. PMID: 27835605 |
Ref: Regulation of white and brown adipocyte differentiation by RhoGAP DLC1. PMID: 28358928 Ref: Resveratrol inhibits age-dependent spontaneous tumorigenesis by SIRT1-mediated post-translational modulations in the annual fish Nothobranchius guentheri. PMID: 28903430 Ref: Comprehensive analysis of long non-coding RNA PVT1 gene interaction regulatory network in hepatocellular carcinoma using gene microarray and bioinformatics. PMID: 28979669 Ref: Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration. PMID: 29084958 |
Ref: The tumor suppressor DLC1 inhibits cancer progression and oncogenic autophagy in hepatocellular carcinoma. PMID: 29785050 Ref: PNPLA3 and TM6SF2 variants as risk factors of hepatocellular carcinoma across various etiologies and severity of underlying liver diseases. PMID: 30289982 |