Primary Site >> Liver Cancer

Gene >> DKK1

Journal: Oncogene. 2005 May 26;24(23):3737-47.
Title: An integrated data analysis approach to characterize genes highly expressed in hepatocellular carcinoma.
Author: Patil, Mohini A|Chua, Mei-Sze|Pan, Kuang-Hung|Lin, Richard|Lih, Chih-Jian|Cheung, Siu-Tim|Ho, Coral|Li, Rui|Fan, Sheung-Tat|Cohen, Stanley N|Chen, Xin|So, Samuel
PMID: 15735714
Journal: J Biol Chem. 2006 Nov 24;281(47):35598-602.
Title: Suppressing Wnt signaling by the hedgehog pathway through sFRP-1.
Author: He, Jing|Sheng, Tao|Stelter, Arwen A|Li, Chengxin|Zhang, Xiaoli|Sinha, Mala|Luxon, Bruce A|Xie, Jingwu
PMID: 17035233
Journal: Zhonghua Gan Zang Bing Za Zhi. 2006 Nov;14(11):824-7.
Title: [Exploration of differential expressed genes involved in the development and progression of hepatocellular carcinoma using oligo microarray].
Author: Liu, Xiu-feng|Shi, Rui-hua|Gao, Heng-jun|Zhu, Hong|Qin, Shu-kui|Wang, Xue-hao
PMID: 17125609
Journal: Int J Mol Med. 2007 Mar;19(3):529-33.
Title: Comparative integromics on FZD7 orthologs: conserved binding sites for PU.1, SP1, CCAAT-box and TCF/LEF/SOX transcription factors within 5'-promoter region of mammalian FZD7 orthologs.
Author: Katoh, Masuko|Katoh, Masaru
PMID: 17273804
Journal: Carcinogenesis. 2007 Dec;28(12):2459-66. Epub 2007 Aug 3.
Title: Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors.
Author: Sato, Hironobu|Suzuki, Hiromu|Toyota, Minoru|Nojima, Masanori|Maruyama, Reo|Sasaki, Shigeru|Takagi, Hideyasu|Sogabe, Yohei|Sasaki, Yasushi|Idogawa, Masashi|Sonoda, Tomoko|Mori, Mitsuru|Imai, Kohzoh|Tokino, Takashi|Shinomura, Yasuhisa
PMID: 17675336
Journal: J Hepatol. 2009 May;50(5):948-57.
Title: Elevated expression of DKK1 is associated with cytoplasmic/nuclear beta-catenin accumulation and poor prognosis in hepatocellular carcinomas.
Author: Yu, Bin|Yang, Xinrong|Xu, Yang|Yao, Genfu|Shu, Huiqun|Lin, Biaoyang|Hood, Leroy|Wang, Hongyang|Yang, Shengli|Gu, Jianren|Fan, Jia|Qin, Wenxin
PMID: 19303159
Journal: Tumour Biol. 2010 Oct;31(5):417-25.
Title: AFP computational secreted network construction and analysis between human hepatocellular carcinoma (HCC) and no-tumor hepatitis/cirrhotic liver tissues.
Author: Wang, Lin|Huang, Juxiang|Jiang, Minghu|Zheng, Xiguang
PMID: 20532728
Journal: Arch Virol. 2011 Jun;156(6):1013-23.
Title: Hepatitis C virus core protein activates Wnt/beta-catenin signaling through multiple regulation of upstream molecules in the SMMC-7721 cell line.
Author: Liu, Jiao|Wang, Zengchan|Tang, Jia|Tang, Renkuan|Shan, Xiaoliang|Zhang, Wenlu|Chen, Qingmei|Zhou, Fan|Chen, Ke|Huang, Ailong|Tang, Ni
PMID: 21340743
Journal: World J Clin Oncol. 2011 Aug 10;2(8):311-25.
Title: Dickkopfs and Wnt/beta-catenin signalling in liver cancer.
Author: Fatima, Sarwat|Lee, Nikki P|Luk, John M
PMID: 21876852
Journal: Liver Int. 2011 Nov;31(10):1494-504.
Title: Clinicopathological and prognostic significance of serum and tissue Dickkopf-1 levels in human hepatocellular carcinoma.
Author: Tung, Edmund Kwok-Kwan|Mak, Carmen Ka-Man|Fatima, Sarwat|Lo, Regina Cheuk-Lam|Zhao, Heng|Zhang, Chunsheng|Dai, Hongyue|Poon, Ronnie Tung-Ping|Yuen, Man-Fung|Lai, Ching-Lung|Li, Jin-jun|Luk, John Moon-Ching|Ng, Irene Oi-Lin
PMID: 21955977
Journal: Hepatology. 2012 Nov;56(5):1631-40.
Title: Hepatitis C virus-induced up-regulation of microRNA-155 promotes hepatocarcinogenesis by activating Wnt signaling.
Author: Zhang, Yiliang|Wei, Wei|Cheng, Na|Wang, Kaihui|Li, Bin|Jiang, Xiaoqing|Sun, Shuhan
PMID: 22610915
Journal: Future Oncol. 2012 Dec;8(12):1525-8.
Title: Significance of serum DKK1 as a diagnostic biomarker in hepatocellular carcinoma.
Author: Tung, Edmund Kwok-Kwan|Ng, Irene Oi-Lin
PMID: 23231514
Journal: PLoS One. 2012;7(10):e47040.
Title: Comparison of the regulation of beta-catenin signaling by type I, type II and type III interferons in hepatocellular carcinoma cells.
Author: Li, Wei|Huang, Xiaojie|Tong, Hongfei|Wang, Yuxuan|Zhang, Tong|Wang, Wen|Dai, Lili|Li, Tongzeng|Lin, Shengzhang|Wu, Hao
PMID: 23056571
Journal: J Recept Signal Transduct Res. 2012 Oct;32(5):250-6.
Title: PTHLH coupling upstream negative regulation of fatty acid biosynthesis and Wnt receptor signal to downstream peptidase activity-induced apoptosis network in human hepatocellular carcinoma by systems-theoretical analysis.
Author: Huang, Juxiang|Wang, Lin|Jiang, Minghu|Lin, Hong|Qi, Lianxiu|Diao, Haizhen
PMID: 22799769
Journal: Lancet Oncol. 2012 Aug;13(8):817-26.
Title: Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study.
Author: Shen, Qiujin|Fan, Jia|Yang, Xin-Rong|Tan, Yexiong|Zhao, Weifeng|Xu, Yang|Wang, Ning|Niu, Yongdong|Wu, Zheng|Zhou, Jian|Qiu, Shuang-Jian|Shi, Ying-Hong|Yu, Bin|Tang, Ning|Chu, Wei|Wang, Min|Wu, Jinhua|Zhang, Zhigang|Yang, Shengli|Gu, Jianren|Wang, Hongyang
PMID: 22738799
Journal: Hepatology. 2012 Oct;56(4):1240-51.
Title: Subset of Suz12/PRC2 target genes is activated during hepatitis B virus replication and liver carcinogenesis associated with HBV X protein.
Author: Studach, Leo L|Menne, Stephan|Cairo, Stefano|Buendia, Marie Annick|Hullinger, Ronald L|Lefrancois, Lydie|Merle, Philippe|Andrisani, Ourania M
PMID: 22505317
Journal: Dig Liver Dis. 2013 Mar;45(3):251-7.
Title: Dickkopf-1 (DKK1) promotes invasion and metastasis of hepatocellular carcinoma.
Author: Tao, Yi-Ming|Liu, Zhen|Liu, He-Li
PMID: 23266194
Journal: PLoS One. 2013 Dec 4;8(12):e81921.
Title: N-glycoproteome analysis of the secretome of human metastatic hepatocellular carcinoma cell lines combining hydrazide chemistry, HILIC enrichment and mass spectrometry.
Author: Li, Xianyu|Jiang, Jing|Zhao, Xinyuan|Wang, Jifeng|Han, Huanhuan|Zhao, Yan|Peng, Bo|Zhong, Rugang|Ying, Wantao|Qian, Xiaohong
PMID: 24324730
Journal: Mol Cancer. 2013 Dec 10;12:157.
Title: DKK1 promotes hepatocellular carcinoma cell migration and invasion through beta-catenin/MMP7 signaling pathway.
Author: Chen, Liang|Li, Ming|Li, Qian|Wang, Chao-Jie|Xie, Song-Qiang
PMID: 24325363
Journal: Hepatobiliary Surg Nutr. 2013 Jun;2(3):127-8.
Title: DKK1 as a serum biomarker for hepatocellular carcinoma.
Author: Prieto, Peter A|Cha, Charles H
PMID: 24570929
Journal: Drug Discov Ther. 2014 Jun;8(3):102-9.
Title: Perspectives on a combined test of multi serum biomarkers in China: towards screening for and diagnosing hepatocellular carcinoma at an earlier stage.
Author: Zhang, Keming|Song, Peipei|Gao, Jianjun|Li, Gaohua|Zhao, Xin|Zhang, Shaogeng
PMID: 25031041
Journal: Int J Biol Markers. 2014 Dec 9;29(4):e403-10.
Title: Sensitivity and specificity of Dickkopf-1 protein in serum for diagnosing hepatocellular carcinoma: a meta-analysis.
Author: Zhang, Jie|Zhao, Ying|Yang, Qin
PMID: 24980448
Journal: Virol J. 2014 Jun 20;11:117.
Title: Promoter hypermethylation of Wnt pathway inhibitors in hepatitis C virus - induced multistep hepatocarcinogenesis.
Author: Umer, Muhammad|Qureshi, Sohail Asif|Hashmi, Zahid Yasin|Raza, Asif|Ahmad, Janbaz|Rahman, Moazur|Iqbal, Mazhar
PMID: 24947038
Journal: Cell Biochem Biophys. 2014 Nov;70(2):1011-6.
Title: CAMK1 phosphoinositide signal-mediated protein sorting and transport network in human hepatocellular carcinoma (HCC) by biocomputation.
Author: Wang, Lin|Huang, Juxiang|Jiang, Minghu|Chen, Qingchun|Jiang, Zhenfu|Feng, Haitao
PMID: 24825433
Journal: Expert Rev Mol Diagn. 2014 Jun;14(5):535-48.
Title: Dysregulated expression of dickkopfs for potential detection of hepatocellular carcinoma.
Author: Fatima, Sarwat|Luk, John M|Poon, Ronnie T P|Lee, Nikki P
PMID: 24809435
Journal: Tumour Biol. 2014 Apr;35(4):3145-54.
Title: Prognostic significance of dickkopf-1 overexpression in solid tumors: a meta-analysis.
Author: Liu, Yanqiong|Tang, Weizhong|Xie, Li|Wang, Jian|Deng, Yan|Peng, Qiliu|Zhai, Limin|Li, Shan|Qin, Xue
PMID: 24258111
Journal: Med Oncol. 2014 Jul;31(7):966.
Title: Overexpression of Dickkopf-1 predicts poor prognosis for patients with hepatocellular carcinoma after orthotopic liver transplantation by promoting cancer metastasis and recurrence.
Author: Huang, Yan|Yang, Xinrong|Zhao, Fengbo|Shen, Qiujin|Wang, Zhiwei|Lv, Xiufang|Hu, Baoying|Yu, Bin|Fan, Jia|Qin, Wenxin
PMID: 24878698
Journal: Liver Int. 2015 Mar;35(3):986-98.
Title: Musashi1 regulates survival of hepatoma cell lines by activation of Wnt signalling pathway.
Author: Chen, Kunlun|Gao, Qing|Zhang, Wei|Liu, Zhongwei|Cai, Jiangyi|Liu, Ying|Xu, Jinkai|Li, Jie|Yang, Yi|Xu, Xin
PMID: 24444033
Journal: J Pathol. 2015 Apr;235(5):784-95.
Title: CUL4B activates Wnt/beta-catenin signalling in hepatocellular carcinoma by repressing Wnt antagonists.
Author: Yuan, Jupeng|Han, Bo|Hu, Huili|Qian, Yanyan|Liu, Zhaojian|Wei, Zhao|Liang, Xiaohong|Jiang, Baichun|Shao, Changshun|Gong, Yaoqin
PMID: 25430888
Journal: Med Oncol. 2015 Mar;32(3):59.
Title: Diagnostic values of alpha-fetoprotein, dickkopf-1, and osteopontin for hepatocellular carcinoma.
Author: Ge, Tianxiang|Shen, Qiujin|Wang, Ning|Zhang, Yurong|Ge, Zhouhong|Chu, Wei|Lv, Xiufang|Zhao, Fengbo|Zhao, Weifeng|Fan, Jia|Qin, Wenxin
PMID: 25652109
Journal: BMC Med Genomics. 2015 Aug 12;8:49.
Title: FoxM1 transactivates PTTG1 and promotes colorectal cancer cell migration and invasion.
Author: Zheng, Yun|Guo, Jinjun|Zhou, Jin|Lu, Jinjian|Chen, Qi|Zhang, Cui|Qing, Chen|Koeffler, H Philip|Tong, Yunguang
PMID: 26264222
Journal: Oncotarget. 2015 Oct 6;6(30):29357-74.
Title: Positive feedback loop of hepatoma-derived growth factor and beta-catenin promotes carcinogenesis of colorectal cancer.
Author: Lian, Jiayan|Tang, Jianming|Shi, Huijuan|Li, Hui|Zhen, Tiantian|Xie, Wenlin|Zhang, Fenfen|Yang, Yang|Han, Anjia
PMID: 26296979
Journal: Onco Targets Ther. 2015 Oct 22;8:3115-22.
Title: Serum dickkopf-1 as a biomarker in screening gastrointestinal cancers: a systematic review and meta-analysis.
Author: Liang, Bin|Zhong, Liansheng|He, Qun|Wang, Shaocheng|Pan, Zhongcheng|Wang, Tianjiao|Zhao, Yujie
PMID: 26543380
Journal: Hepat Oncol. 2015 Jul;2(3):231-244.
Title: High level of serum protein DKK1 predicts poor prognosis for patients with hepatocellular carcinoma after hepatectomy.
Author: Shen, Qiujin|Yang, Xin-Rong|Tan, Yexiong|You, Haiyan|Xu, Yang|Chu, Wei|Ge, Tianxiang|Zhou, Jian|Qiu, Shuang-Jian|Shi, Ying-Hong|Zhang, Zhigang|Gu, Jianren|Wang, Hongyang|Fan, Jia|Qin, Wenxin
PMID: 30191005
Journal: Turk J Gastroenterol. 2016 Jul;27(4):375-81.
Title: Combination of DKK1 and AFP improves diagnostic accuracy of hepatocellular carcinoma compared with either marker alone.
Author: Erdal, Harun|Gul Utku, Ozlem|Karatay, Eylem|Celik, Bulent|Elbeg, Sehri|Dogan, Ibrahim
PMID: 27458854
Journal: Int J Biochem Cell Biol. 2016 Dec;81(Pt A):195-207.
Title: Fibrous nests in human hepatocellular carcinoma express a Wnt-induced gene signature associated with poor clinical outcome.
Author: Desert, Romain|Mebarki, Sihem|Desille, Mireille|Sicard, Marie|Lavergne, Elise|Renaud, Stephanie|Bergeat, Damien|Sulpice, Laurent|Perret, Christine|Turlin, Bruno|Clement, Bruno|Musso, Orlando
PMID: 27545991
Journal: Scand J Clin Lab Invest Suppl. 2016;245:S70-6.
Title: Biomarkers: evaluation of clinical utility in surveillance and early diagnosis for hepatocellular carcinoma.
Author: Song, Peipei|Tang, Qi|Feng, Xiaobin|Tang, Wei
PMID: 27438343
Journal: PLoS One. 2016 May 24;11(5):e0155800.
Title: Midkine Increases Diagnostic Yield in AFP Negative and NASH-Related Hepatocellular Carcinoma.
Author: Vongsuvanh, Roslyn|van der Poorten, David|Iseli, Tristan|Strasser, Simone I|McCaughan, Geoffrey W|George, Jacob
PMID: 27219517
Journal: Scand J Gastroenterol. 2016 Sep;51(9):1133-7.
Title: Clinical significance and diagnostic value of serum dickkopf-1 in patients with hepatocellular carcinoma.
Author: Fouad, Yasser M|Mohamed, Hala I|Kamal, Enas M|Rasek, Mohamed A
PMID: 27161933
Journal: Tumour Biol. 2016 Aug;37(8):11321-9.
Title: miR-522 contributes to cell proliferation of hepatocellular carcinoma by targeting DKK1 and SFRP2.
Author: Zhang, Hao|Yu, Chao|Chen, Meiyuan|Li, Zhu|Tian, Se|Jiang, Jianxin|Sun, Chengyi
PMID: 26960688
Journal: Acta Biochim Pol. 2017;64(1):35-39.
Title: HBx and SP1 upregulate DKK1 expression.
Author: Peng, Hong|Li, Yongguo|Liu, Yunzhi|Zhang, Jingnan|Chen, Ke|Huang, Ailong|Tang, Hua
PMID: 27723845
Journal: EMBO Mol Med. 2017 Jun;9(6):741-749.
Title: Hepatic stellate cells limit hepatocellular carcinoma progression through the orphan receptor endosialin.
Author: Mogler, Carolin|Konig, Courtney|Wieland, Matthias|Runge, Anja|Besemfelder, Eva|Komljenovic, Dorde|Longerich, Thomas|Schirmacher, Peter|Augustin, Hellmut G
PMID: 28373218
Journal: Int J Cancer. 2017 Jul 15;141(2):354-363.
Title: Hepatic expression of oncogenes Bmi1 and Dkk1 is up-regulated in hepatitis B virus surface antigen-transgenic mice and can be induced by treatment with HBV particles or lipopolysaccharides in vitro.
Author: Zhang, Rui|Real, Catherine I|Liu, Chao|Baba, Hideo A|Gerken, Guido|Lu, Mengji|Broering, Ruth
PMID: 28419472
Journal: Int J Biochem Cell Biol. 2017 Aug;89:157-170.
Title: Genes directly regulated by NF-kappaB in human hepatocellular carcinoma HepG2.
Author: Dai, Wei|Wu, Jian|Zhang, Shuyan|Shi, Bingjie|Xu, Xinhui|Wang, Danyang|Wang, Jinke
PMID: 28579529
Journal: Oncol Rep. 2017 Oct;38(4):2351-2359.
Title: miR-217 targeting DKK1 promotes cancer stem cell properties via activation of the Wnt signaling pathway in hepatocellular carcinoma.
Author: Jiang, Chunlin|Yu, Miao|Xie, Xiaoyan|Huang, Guangliang|Peng, Yao|Ren, Dong|Lin, Manxia|Liu, Baoxian|Liu, Ming|Wang, Wei|Kuang, Ming
PMID: 28849121
Journal: Anticancer Res. 2017 Sep;37(9):4881-4888.
Title: Expression of Cancer Stem Cell-associated DKK1 mRNA Serves as Prognostic Marker for Hepatocellular Carcinoma.
Author: Sakabe, Tomohiko|Azumi, Junya|Umekita, Yoshihisa|Toriguchi, Kan|Hatano, Etsuro|Hirooka, Yasuaki|Shiota, Goshi
PMID: 28870909
Journal: PLoS One. 2017 Sep 13;12(9):e0183880.
Title: TEMs but not DKK1 could serve as complementary biomarkers for AFP in diagnosing AFP-negative hepatocellular carcinoma.
Author: Mao, Liping|Wang, Yueguo|Wang, Delin|Han, Gang|Fu, Shouzhong|Wang, Jianxin
PMID: 28902891
Journal: Mol Oncol. 2018 Jan;12(1):89-113.
Title: Tumor-adjacent tissue co-expression profile analysis reveals pro-oncogenic ribosomal gene signature for prognosis of resectable hepatocellular carcinoma.
Author: Grinchuk, Oleg V|Yenamandra, Surya P|Iyer, Ramakrishnan|Singh, Malay|Lee, Hwee Kuan|Lim, Kiat Hon|Chow, Pierce Kah-Hoe|Kuznetsov, Vladamir A
PMID: 29117471
Journal: J Cancer. 2018 Feb 27;9(5):914-922.
Title: Targeting hepatocarcinogenesis model in C56BL6 mice with pan-aurora kinase inhibitor Danusertib.
Author: Gavriilidis, Paschalis|Poutahidis, Theofilos|Giakoustidis, Alexander|Makedou, Kali|Angelopoulou, Katerina|Hardas, Alexander|Andreani, Paola|Zacharioudaki, Argyro|Saridis, George|Gargavanis, Athanasios|Louri, Eleni|Antoniadis, Nikolaos|Karampela, Eleftheri
PMID: 29581770
Journal: Artif Cells Nanomed Biotechnol. 2018 Mar 27:1-9.
Title: Dishevelled 1, a pivotal positive regulator of the Wnt signalling pathway, mediates 5-fluorouracil resistance in HepG2 cells.
Author: Xu, Yisong|Zhang, Cheng|Liang, Hui|Hu, Shanshuang|Li, Pengkun|Liu, Linna|Duan, Xianglong|Chen, Chao|Zhang, Yani|Dai, Penggao
PMID: 29583038
Journal: Pathol Res Pract. 2018 Jun;214(6):814-820.
Title: Long-term prognostic impact of osteopontin and Dickkopf-related protein 1 in patients with hepatocellular carcinoma after hepatectomy.
Author: Byeon, Hyerim|Lee, Seung Duk|Hong, Eun-Kyung|Lee, Dong Eun|Kim, Bo Hyun|Seo, Yunsung|Joo, Jungnam|Han, Sung-Sik|Kim, Seong Hoon|Park, Sang-Jae
PMID: 29753515
Journal: Int J Mol Med. 2018 Aug;42(2):713-725.
Title: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review).
Author: Katoh, Masaru
PMID: 29786110
Journal: PLoS One. 2018 Jun 26;13(6):e0198937.
Title: Supervised learning reveals circulating biomarker levels diagnostic of hepatocellular carcinoma in a clinically relevant model of non-alcoholic steatohepatitis; An OAD to NASH.
Author: Hwang, Anne|Shi, Christopher|Zhu, Edward|Naaz, Farha|Zhou, Ping|Rasheed, Zainab|Liu, Michelle|Jung, Lindsey S|Duan, Bin|Li, Jingsong|Jiang, Kai|Paka, Latha|Gadhiya, Satishkumar V|Dana, Dibyendu|Ali, Quaisar|Yamin, Michael A|Goldberg, Itzhak D|Narayan, Pra
PMID: 29944670