Primary Site >> Liver Cancer
Gene >> DKK1
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Ref: An integrated data analysis approach to characterize genes highly expressed in hepatocellular carcinoma. PMID: 15735714 |
Ref: Suppressing Wnt signaling by the hedgehog pathway through sFRP-1. PMID: 17035233 Ref: [Exploration of differential expressed genes involved in the development and progression of hepatocellular carcinoma using oligo microarray]. PMID: 17125609 |
Ref: Comparative integromics on FZD7 orthologs: conserved binding sites for PU.1, SP1, CCAAT-box and TCF/LEF/SOX transcription factors within 5'-promoter region of mammalian FZD7 orthologs. PMID: 17273804 Ref: Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors. PMID: 17675336 |
Ref: Elevated expression of DKK1 is associated with cytoplasmic/nuclear beta-catenin accumulation and poor prognosis in hepatocellular carcinomas. PMID: 19303159 |
Ref: AFP computational secreted network construction and analysis between human hepatocellular carcinoma (HCC) and no-tumor hepatitis/cirrhotic liver tissues. PMID: 20532728 |
Ref: Hepatitis C virus core protein activates Wnt/beta-catenin signaling through multiple regulation of upstream molecules in the SMMC-7721 cell line. PMID: 21340743 Ref: Dickkopfs and Wnt/beta-catenin signalling in liver cancer. PMID: 21876852 Ref: Clinicopathological and prognostic significance of serum and tissue Dickkopf-1 levels in human hepatocellular carcinoma. PMID: 21955977 |
Ref: Subset of Suz12/PRC2 target genes is activated during hepatitis B virus replication and liver carcinogenesis associated with HBV X protein. PMID: 22505317 Ref: Hepatitis C virus-induced up-regulation of microRNA-155 promotes hepatocarcinogenesis by activating Wnt signaling. PMID: 22610915 Ref: Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study. PMID: 22738799 Ref: PTHLH coupling upstream negative regulation of fatty acid biosynthesis and Wnt receptor signal to downstream peptidase activity-induced apoptosis network in human hepatocellular carcinoma by systems-theoretical analysis. PMID: 22799769 Ref: Comparison of the regulation of beta-catenin signaling by type I, type II and type III interferons in hepatocellular carcinoma cells. PMID: 23056571 Ref: Significance of serum DKK1 as a diagnostic biomarker in hepatocellular carcinoma. PMID: 23231514 |
Ref: Dickkopf-1 (DKK1) promotes invasion and metastasis of hepatocellular carcinoma. PMID: 23266194 Ref: N-glycoproteome analysis of the secretome of human metastatic hepatocellular carcinoma cell lines combining hydrazide chemistry, HILIC enrichment and mass spectrometry. PMID: 24324730 Ref: DKK1 promotes hepatocellular carcinoma cell migration and invasion through beta-catenin/MMP7 signaling pathway. PMID: 24325363 Ref: DKK1 as a serum biomarker for hepatocellular carcinoma. PMID: 24570929 |
Ref: Prognostic significance of dickkopf-1 overexpression in solid tumors: a meta-analysis. PMID: 24258111 Ref: Dysregulated expression of dickkopfs for potential detection of hepatocellular carcinoma. PMID: 24809435 Ref: CAMK1 phosphoinositide signal-mediated protein sorting and transport network in human hepatocellular carcinoma (HCC) by biocomputation. PMID: 24825433 Ref: Overexpression of Dickkopf-1 predicts poor prognosis for patients with hepatocellular carcinoma after orthotopic liver transplantation by promoting cancer metastasis and recurrence. PMID: 24878698 Ref: Promoter hypermethylation of Wnt pathway inhibitors in hepatitis C virus - induced multistep hepatocarcinogenesis. PMID: 24947038 Ref: Sensitivity and specificity of Dickkopf-1 protein in serum for diagnosing hepatocellular carcinoma: a meta-analysis. PMID: 24980448 Ref: Perspectives on a combined test of multi serum biomarkers in China: towards screening for and diagnosing hepatocellular carcinoma at an earlier stage. PMID: 25031041 |
Ref: Musashi1 regulates survival of hepatoma cell lines by activation of Wnt signalling pathway. PMID: 24444033 Ref: CUL4B activates Wnt/beta-catenin signalling in hepatocellular carcinoma by repressing Wnt antagonists. PMID: 25430888 Ref: Diagnostic values of alpha-fetoprotein, dickkopf-1, and osteopontin for hepatocellular carcinoma. PMID: 25652109 Ref: FoxM1 transactivates PTTG1 and promotes colorectal cancer cell migration and invasion. PMID: 26264222 Ref: Positive feedback loop of hepatoma-derived growth factor and beta-catenin promotes carcinogenesis of colorectal cancer. PMID: 26296979 Ref: Serum dickkopf-1 as a biomarker in screening gastrointestinal cancers: a systematic review and meta-analysis. PMID: 26543380 Ref: High level of serum protein DKK1 predicts poor prognosis for patients with hepatocellular carcinoma after hepatectomy. PMID: 30191005 |
Ref: miR-522 contributes to cell proliferation of hepatocellular carcinoma by targeting DKK1 and SFRP2. PMID: 26960688 Ref: Clinical significance and diagnostic value of serum dickkopf-1 in patients with hepatocellular carcinoma. PMID: 27161933 Ref: Midkine Increases Diagnostic Yield in AFP Negative and NASH-Related Hepatocellular Carcinoma. PMID: 27219517 Ref: Biomarkers: evaluation of clinical utility in surveillance and early diagnosis for hepatocellular carcinoma. PMID: 27438343 Ref: Combination of DKK1 and AFP improves diagnostic accuracy of hepatocellular carcinoma compared with either marker alone. PMID: 27458854 Ref: Fibrous nests in human hepatocellular carcinoma express a Wnt-induced gene signature associated with poor clinical outcome. PMID: 27545991 |
Ref: HBx and SP1 upregulate DKK1 expression. PMID: 27723845 Ref: Hepatic stellate cells limit hepatocellular carcinoma progression through the orphan receptor endosialin. PMID: 28373218 Ref: Hepatic expression of oncogenes Bmi1 and Dkk1 is up-regulated in hepatitis B virus surface antigen-transgenic mice and can be induced by treatment with HBV particles or lipopolysaccharides in vitro. PMID: 28419472 Ref: Genes directly regulated by NF-kappaB in human hepatocellular carcinoma HepG2. PMID: 28579529 Ref: miR-217 targeting DKK1 promotes cancer stem cell properties via activation of the Wnt signaling pathway in hepatocellular carcinoma. PMID: 28849121 Ref: Expression of Cancer Stem Cell-associated DKK1 mRNA Serves as Prognostic Marker for Hepatocellular Carcinoma. PMID: 28870909 Ref: TEMs but not DKK1 could serve as complementary biomarkers for AFP in diagnosing AFP-negative hepatocellular carcinoma. PMID: 28902891 |
Ref: Tumor-adjacent tissue co-expression profile analysis reveals pro-oncogenic ribosomal gene signature for prognosis of resectable hepatocellular carcinoma. PMID: 29117471 Ref: Targeting hepatocarcinogenesis model in C56BL6 mice with pan-aurora kinase inhibitor Danusertib. PMID: 29581770 Ref: Dishevelled 1, a pivotal positive regulator of the Wnt signalling pathway, mediates 5-fluorouracil resistance in HepG2 cells. PMID: 29583038 Ref: Long-term prognostic impact of osteopontin and Dickkopf-related protein 1 in patients with hepatocellular carcinoma after hepatectomy. PMID: 29753515 Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review). PMID: 29786110 Ref: Supervised learning reveals circulating biomarker levels diagnostic of hepatocellular carcinoma in a clinically relevant model of non-alcoholic steatohepatitis; An OAD to NASH. PMID: 29944670 |