Primary Site >> Colorectal Cancer

Gene >> DCLK1

Journal: Br J Cancer. 2002 May 20;86(10):1634-8.
Title: Anti-tumour activity and toxicity of the new prodrug 9-aminocamptothecin glucuronide (9ACG) in mice.
Author: Prijovich, Z M|Chen, B-M|Leu, Y-L|Chern, J-W|Roffler, S R
PMID: 12085215
Journal: J Clin Invest. 2009 Sep;119(9):2691-701.
Title: Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice.
Author: Jin, Guangchun|Ramanathan, Vigneshwaran|Quante, Michael|Baik, Gwang Ho|Yang, Xiangdong|Wang, Sophie S W|Tu, Shuiping|Gordon, Shanisha A K|Pritchard, David Mark|Varro, Andrea|Shulkes, Arthur|Wang, Timothy C
PMID: 19652364
Journal: Mol Carcinog. 2010 Mar;49(3):235-46.
Title: The synergistic anticancer effect of troglitazone combined with aspirin causes cell cycle arrest and apoptosis in human lung cancer cells.
Author: Yan, Kun-Huang|Yao, Chih-Jung|Chang, Hwan-You|Lai, Gi-Ming|Cheng, Ann-Lii|Chuang, Shuang-En
PMID: 19908241
Journal: Cancer Gene Ther. 2011 Jun;18(6):381-9.
Title: Enhancement of CPT-11 antitumor activity by adenovirus-mediated expression of beta-glucuronidase in tumors.
Author: Huang, P-T|Chen, K-C|Prijovich, Z M|Cheng, T-L|Leu, Y-L|Roffler, S R
PMID: 21350582
Journal: Mol Cancer Ther. 2012 Apr;11(4):963-72.
Title: Honokiol in combination with radiation targets notch signaling to inhibit colon cancer stem cells.
Author: Ponnurangam, Sivapriya|Mammen, Joshua M V|Ramalingam, Satish|He, Zhiyun|Zhang, Youcheng|Umar, Shahid|Subramaniam, Dharmalingam|Anant, Shrikant
PMID: 22319203
Journal: PLoS One. 2012;7(2):e32492.
Title: Kruppel-like factor 4 regulates intestinal epithelial cell morphology and polarity.
Author: Yu, Tianxin|Chen, Xi|Zhang, Wen|Li, Juan|Xu, Ren|Wang, Timothy C|Ai, Walden|Liu, Chunming
PMID: 22384261
Journal: Lab Invest. 2012 Jun;92(6):883-95.
Title: Gastric tumor development in Smad3-deficient mice initiates from forestomach/glandular transition zone along the lesser curvature.
Author: Nam, Ki Taek|O'Neal, Ryan|Lee, Yeo Song|Lee, Yong Chan|Coffey, Robert J|Goldenring, James R
PMID: 22411066
Journal: Clin Exp Gastroenterol. 2012;5:35-42.
Title: DCLK1 immunoreactivity in colorectal neoplasia.
Author: Gagliardi, Giuseppe|Goswami, Monica|Passera, Roberto|Bellows, Charles F
PMID: 22557932
Journal: Evid Based Complement Alternat Med. 2012;2012:261971.
Title: Momordica charantia Extract Induces Apoptosis in Human Cancer Cells through Caspase- and Mitochondria-Dependent Pathways.
Author: Li, Chia-Jung|Tsang, Shih-Fang|Tsai, Chun-Hao|Tsai, Hsin-Yi|Chyuan, Jong-Ho|Hsu, Hsue-Yin
PMID: 23091557
Journal: Nat Genet. 2013 Jan;45(1):98-103.
Title: Dclk1 distinguishes between tumor and normal stem cells in the intestine.
Author: Nakanishi, Yuki|Seno, Hiroshi|Fukuoka, Ayumi|Ueo, Taro|Yamaga, Yuichi|Maruno, Takahisa|Nakanishi, Naoko|Kanda, Keitaro|Komekado, Hideyuki|Kawada, Mayumi|Isomura, Akihiro|Kawada, Kenji|Sakai, Yoshiharu|Yanagita, Motoko|Kageyama, Ryoichiro|Kawaguchi, Yoshiy
PMID: 23202126
Journal: Evid Based Complement Alternat Med. 2013;2013:702869.
Title: Methanolic extracts of bitter melon inhibit colon cancer stem cells by affecting energy homeostasis and autophagy.
Author: Kwatra, Deep|Subramaniam, Dharmalingam|Ramamoorthy, Prabhu|Standing, David|Moran, Elizabeth|Velayutham, Ravichandiran|Mitra, Ashim|Umar, Shahid|Anant, Shrikant
PMID: 23533514
Journal: Chin J Cancer Res. 2013 Apr;25(2):134-42.
Title: Doublecortin-like kinase 1 exhibits cancer stem cell-like characteristics in a human colon cancer cell line.
Author: Li, Lianna|Bellows, Charles F
PMID: 23592893
Journal: Carcinogenesis. 2014 Apr;35(4):795-806.
Title: Prolactin signaling enhances colon cancer stemness by modulating Notch signaling in a Jak2-STAT3/ERK manner.
Author: Neradugomma, Naveen K|Subramaniam, Dharmalingam|Tawfik, Ossama W|Goffin, Vincent|Kumar, T Rajendra|Jensen, Roy A|Anant, Shrikant
PMID: 24265293
Journal: Oncotarget. 2014 Oct 15;5(19):9269-80.
Title: DCLK1 facilitates intestinal tumor growth via enhancing pluripotency and epithelial mesenchymal transition.
Author: Chandrakesan, Parthasarathy|Weygant, Nathaniel|May, Randal|Qu, Dongfeng|Chinthalapally, Harisha R|Sureban, Sripathi M|Ali, Naushad|Lightfoot, Stan A|Umar, Shahid|Houchen, Courtney W
PMID: 25211188
Journal: Cancer Res. 2014 Nov 1;74(21):6119-28.
Title: Stress response protein cirp links inflammation and tumorigenesis in colitis-associated cancer.
Author: Sakurai, Toshiharu|Kashida, Hiroshi|Watanabe, Tomohiro|Hagiwara, Satoru|Mizushima, Tsunekazu|Iijima, Hideki|Nishida, Naoshi|Higashitsuji, Hiroaki|Fujita, Jun|Kudo, Masatoshi
PMID: 25187386
Journal: Genomics. 2014 Oct;104(4):234-41.
Title: Patterns of somatic alterations between matched primary and metastatic colorectal tumors characterized by whole-genome sequencing.
Author: Xie, Tao|Cho, Yong Beom|Wang, Kai|Huang, Donghui|Hong, Hye Kyung|Choi, Yoon-La|Ko, Young Hyeh|Nam, Do-Hyun|Jin, Juyoun|Yang, Heekyoung|Fernandez, Julio|Deng, Shibing|Rejto, Paul A|Lee, Woo Yong|Mao, Mao
PMID: 25066378
Journal: Clin Cancer Res. 2014 Jun 15;20(12):3261-71.
Title: CHFR promoter methylation indicates poor prognosis in stage II microsatellite stable colorectal cancer.
Author: Cleven, Arjen H G|Derks, Sarah|Draht, Muriel X G|Smits, Kim M|Melotte, Veerle|Van Neste, Leander|Tournier, Benjamin|Jooste, Valerie|Chapusot, Caroline|Weijenberg, Matty P|Herman, James G|de Bruine, Adriaan P|van Engeland, Manon
PMID: 24928946
Journal: Cancer Res. 2014 May 1;74(9):2487-98.
Title: Curcumin promotes autophagic survival of a subset of colon cancer stem cells, which are ablated by DCLK1-siRNA.
Author: Kantara, Carla|O'Connell, Malaney|Sarkar, Shubhashish|Moya, Stephanie|Ullrich, Robert|Singh, Pomila
PMID: 24626093
Journal: J Clin Invest. 2014 Mar;124(3):1283-95.
Title: Long-lived intestinal tuft cells serve as colon cancer-initiating cells.
Author: Westphalen, C Benedikt|Asfaha, Samuel|Hayakawa, Yoku|Takemoto, Yoshihiro|Lukin, Dana J|Nuber, Andreas H|Brandtner, Anna|Setlik, Wanda|Remotti, Helen|Muley, Ashlesha|Chen, Xiaowei|May, Randal|Houchen, Courtney W|Fox, James G|Gershon, Michael D|Quante, Mich
PMID: 24487592
Journal: Epigenetics. 2014 Mar;9(3):346-50.
Title: The recently suggested intestinal cancer stem cell marker DCLK1 is an epigenetic biomarker for colorectal cancer.
Author: Vedeld, Hege Marie|Skotheim, Rolf I|Lothe, Ragnhild A|Lind, Guro E
PMID: 24384857
Journal: Sci Rep. 2015 Oct 8;5:14983.
Title: Epigenetic changes and alternate promoter usage by human colon cancers for expressing DCLK1-isoforms: Clinical Implications.
Author: O'Connell, Malaney R|Sarkar, Shubhashish|Luthra, Gurinder K|Okugawa, Yoshinaga|Toiyama, Yuji|Gajjar, Aakash H|Qiu, Suimin|Goel, Ajay|Singh, Pomila
PMID: 26447334
Journal: Curr Pharmacol Rep. 2015 Aug 1;1(4):217-222.
Title: Regulation of miRNAs by agents targeting the tumor stem cell markers DCLK1, MSI1, LGR5, and BMI1.
Author: Sureban, Sripathi M|Qu, Dongfeng|Houchen, Courtney W
PMID: 26366338
Journal: PLoS One. 2015 Aug 18;10(8):e0134212.
Title: Ablation of Doublecortin-Like Kinase 1 in the Colonic Epithelium Exacerbates Dextran Sulfate Sodium-Induced Colitis.
Author: Qu, Dongfeng|Weygant, Nathaniel|May, Randal|Chandrakesan, Parthasarathy|Madhoun, Mohammad|Ali, Naushad|Sureban, Sripathi M|An, Guangyu|Schlosser, Michael J|Houchen, Courtney W
PMID: 26285154
Journal: Oncotarget. 2015 Aug 21;6(24):20327-44.
Title: Inflammatory and oncogenic roles of a tumor stem cell marker doublecortin-like kinase (DCLK1) in virus-induced chronic liver diseases.
Author: Ali, Naushad|Chandrakesan, Parthasarathy|Nguyen, Charles B|Husain, Sanam|Gillaspy, Allison F|Huycke, Mark|Berry, William L|May, Randal|Qu, Dongfeng|Weygant, Nathaniel|Sureban, Sripathi M|Bronze, Michael S|Dhanasekaran, Danny N|Houchen, Courtney W
PMID: 25948779
Journal: PLoS One. 2015 Feb 27;10(2):e0118933.
Title: Doublecortin-like kinase 1 is elevated serologically in pancreatic ductal adenocarcinoma and widely expressed on circulating tumor cells.
Author: Qu, Dongfeng|Johnson, Jeremy|Chandrakesan, Parthasarathy|Weygant, Nathaniel|May, Randal|Aiello, Nicole|Rhim, Andrew|Zhao, Lichao|Zheng, Wei|Lightfoot, Stanley|Pant, Shubham|Irvan, Jeremy|Postier, Russell|Hocker, James|Hanas, Jay S|Ali, Naushad|Sureban, Sr
PMID: 25723399
Journal: Oncotarget. 2015 Feb 10;6(4):2193-205.
Title: DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma.
Author: Weygant, Nathaniel|Qu, Dongfeng|May, Randal|Tierney, Ryan M|Berry, William L|Zhao, Lichao|Agarwal, Shweta|Chandrakesan, Parthasarathy|Chinthalapally, Harisha R|Murphy, Nicholas T|Li, James D|Sureban, Sripathi M|Schlosser, Michael J|Tomasek, James J|Houche
PMID: 25605241
Journal: J Proteome Res. 2015 Mar 6;14(3):1535-46.
Title: Differential reprogramming of isogenic colorectal cancer cells by distinct activating KRAS mutations.
Author: Hammond, Dean E|Mageean, Craig J|Rusilowicz, Emma V|Wickenden, Julie A|Clague, Michael J|Prior, Ian A
PMID: 25599653
Journal: Lab Invest. 2015 Jan;95(1):100-12.
Title: Methods for detecting circulating cancer stem cells (CCSCs) as a novel approach for diagnosis of colon cancer relapse/metastasis.
Author: Kantara, Carla|O'Connell, Malaney Ravae|Luthra, Gurinder|Gajjar, Aakash|Sarkar, Shubhashish|Ullrich, Robert Leo|Singh, Pomila
PMID: 25347154
Journal: Int J Cancer. 2015 Feb 15;136(4):844-53.
Title: The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers.
Author: Vedeld, Hege Marie|Andresen, Kim|Eilertsen, Ina Andrassy|Nesbakken, Arild|Seruca, Raquel|Gladhaug, Ivar P|Thiis-Evensen, Espen|Rognum, Torleiv O|Boberg, Kirsten Muri|Lind, Guro E
PMID: 24948044
Journal: Tumour Biol. 2015 Jun;36(6):4801-10.
Title: Upregulation of circulating cancer stem cell marker, DCLK1 but not Lgr5, in chemoradiotherapy-treated colorectal cancer patients.
Author: Mirzaei, Alireza|Tavoosidana, Gholamreza|Modarressi, Mohammad Hossein|Rad, Afshin Abdi|Fazeli, Mohammad Sadegh|Shirkoohi, Reza|Tavakoli-Yaraki, Masoumeh|Madjd, Zahra
PMID: 25631749
Journal: Cancer Biomark. 2016 Sep 26;17(3):301-311.
Title: Evaluation of circulating cellular DCLK1 protein, as the most promising colorectal cancer stem cell marker, using immunoassay based methods.
Author: Mirzaei, Alireza|Madjd, Zahra|Kadijani, Azade Amini|Tavakoli-Yaraki, Masoumeh|Modarresi, Mohammad Hossein|Verdi, Javad|Akbari, Abolfazl|Tavoosidana, Gholamreza
PMID: 27802206
Journal: Stem Cell Investig. 2016 Sep 28;3:51.
Title: Epigenetic regulation of human DCLK-1 gene during colon-carcinogenesis: clinical and mechanistic implications.
Author: Singh, Pomila|O'Connell, Malaney|Shubhashish, Sarkar
PMID: 27777940
Journal: Cancer Prev Res (Phila). 2016 Oct;9(10):812-820.
Title: Dietary Methyl Donor Depletion Suppresses Intestinal Adenoma Development.
Author: Hanley, Matthew P|Kadaveru, Krishna|Perret, Christine|Giardina, Charles|Rosenberg, Daniel W
PMID: 27530130
Journal: J Cancer Res Clin Oncol. 2016 Oct;142(10):2131-40.
Title: DCLK1 is up-regulated and associated with metastasis and prognosis in colorectal cancer.
Author: Gao, Tianbo|Wang, Min|Xu, Lingling|Wen, Tao|Liu, Jian|An, Guangyu
PMID: 27520310
Journal: BMC Cancer. 2016 Jul 7;16:425.
Title: The eicosanoids leukotriene D4 and prostaglandin E2 promote the tumorigenicity of colon cancer-initiating cells in a xenograft mouse model.
Author: Bellamkonda, Kishan|Chandrashekar, Naveen Kumar|Osman, Janina|Selvanesan, Benson Chellakkan|Savari, Sayeh|Sjolander, Anita
PMID: 27388564
Journal: Mol Cancer Res. 2016 Apr;14(4):354-62.
Title: miR-137 Regulates the Tumorigenicity of Colon Cancer Stem Cells through the Inhibition of DCLK1.
Author: Sakaguchi, Masazumi|Hisamori, Shigeo|Oshima, Nobu|Sato, Fumiaki|Shimono, Yohei|Sakai, Yoshiharu
PMID: 26747706
Journal: Tumour Biol. 2016 Feb;37(2):2405-14.
Title: A new insight into cancer stem cell markers: Could local and circulating cancer stem cell markers correlate in colorectal cancer?
Author: Mirzaei, Alireza|Tavoosidana, Gholamreza|Rad, Afshin Abdi|Rezaei, Farhad|Tavakoli-Yaraki, Masoumeh|Kadijani, Azade Amini|Khalili, Ehsan|Madjd, Zahra
PMID: 26383518
Journal: Mol Carcinog. 2016 Nov;55(11):1503-1516.
Title: RNA binding protein RBM3 increases beta-catenin signaling to increase stem cell characteristics in colorectal cancer cells.
Author: Venugopal, Anand|Subramaniam, Dharmalingam|Balmaceda, Julia|Roy, Badal|Dixon, Dan A|Umar, Shahid|Weir, Scott J|Anant, Shrikant
PMID: 26331352
Journal: Clin Transl Oncol. 2016 Apr;18(4):398-404.
Title: Methylation of the DCLK1 promoter region in circulating free DNA and its prognostic value in lung cancer patients.
Author: Powrozek, T|Krawczyk, P|Nicos, M|Kuznar-Kaminska, B|Batura-Gabryel, H|Milanowski, J
PMID: 26311076
Journal: Carcinogenesis. 2016 Apr;37(4):385-96.
Title: An ornamental plant targets epigenetic signaling to block cancer stem cell-driven colon carcinogenesis.
Author: Ahmed, Ishfaq|Roy, Badal C|Subramaniam, Dharmalingam|Ganie, Showkat Ahmad|Kwatra, Deep|Dixon, Dan|Anant, Shrikant|Zargar, Mohammad Afzal|Umar, Shahid
PMID: 26785732
Journal: Sci Rep. 2017 Sep 8;7(1):10939.
Title: SATB2/beta-catenin/TCF-LEF pathway induces cellular transformation by generating cancer stem cells in colorectal cancer.
Author: Yu, Wei|Ma, Yiming|Shankar, Sharmila|Srivastava, Rakesh K
PMID: 28887549
Journal: J Biomed Nanotechnol. 2017 Feb;13(2):192-03.
Title: Development of pH-Sensitive Cationic PEGylated Solid Lipid Nanoparticles for Selective Cancer-Targeted Therapy.
Author: Chuang, Chih-Hung|Wu, Pao-Chu|Tsai, Teng-Huang|Fang, Yi-Ping|Tsai, Yi-Hung|Cheng, Ta-Chun|Huang, Chien-Chaio|Huang, Ming-Yii|Chen, Fang-Ming|Hsieh, Yuan-Chin|Lin, Wen-Wei|Tsai, Ming-Jun|Cheng, Tian-Lu
PMID: 29377649
Journal: Oncotarget. 2017 Nov 1;8(60):102176-102190.
Title: Commensal-infected macrophages induce dedifferentiation and reprogramming of epithelial cells during colorectal carcinogenesis.
Author: Wang, Xingmin|Yang, Yonghong|Huycke, Mark M
PMID: 29254234
Journal: Mol Cancer Res. 2017 Dec;15(12):1678-1691.
Title: FOXD3 Regulates CSC Marker, DCLK1-S, and Invasive Potential: Prognostic Implications in Colon Cancer.
Author: Sarkar, Shubhashish|O'Connell, Malaney R|Okugawa, Yoshinaga|Lee, Brian S|Toiyama, Yuji|Kusunoki, Masato|Daboval, Robert D|Goel, Ajay|Singh, Pomila
PMID: 28851816
Journal: Lab Invest. 2017 Oct;97(10):1245-1261.
Title: A novel antibody against cancer stem cell biomarker, DCLK1-S, is potentially useful for assessing colon cancer risk after screening colonoscopy.
Author: Sarkar, Shubhashish|Popov, Vsevolod L|O'Connell, Malaney R|Stevenson, Heather L|Lee, Brian S|Obeid, Robert A|Luthra, Gurinder K|Singh, Pomila
PMID: 28414327
Journal: Mol Cancer. 2017 Feb 1;16(1):30.
Title: Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells.
Author: Chandrakesan, Parthasarathy|Yao, Jiannan|Qu, Dongfeng|May, Randal|Weygant, Nathaniel|Ge, Yang|Ali, Naushad|Sureban, Sripathi M|Gude, Modhi|Vega, Kenneth|Bannerman-Menson, Eddie|Xia, Lijun|Bronze, Michael|An, Guangyu|Houchen, Courtney W
PMID: 28148261
Journal: J Cell Physiol. 2017 Jul;232(7):1879-1884.
Title: Identification of MSX1 and DCLK1 as mRNA Biomarkers for Colorectal Cancer Detection Through DNA Methylation Information.
Author: Sun, Ai-Jun|Gao, Hai-Bo|Liu, Gao|Ge, Heng-Fa|Ke, Zun-Ping|Li, Sen
PMID: 27966796
Journal: Int J Cancer. 2018 May 15;142(10):2068-2079.
Title: DCLK1 promotes epithelial-mesenchymal transition via the PI3K/Akt/NF-kappaB pathway in colorectal cancer.
Author: Liu, Weiying|Wang, Shixing|Sun, Qi|Yang, Zhen|Liu, Min|Tang, Hua
PMID: 29277893
Journal: Biomed Rep. 2018 Jan;8(1):47-50.
Title: Expression of doublecortin and CaM kinase-like-1 protein in serrated neoplasia of the colorectum.
Author: Morio, Keiko|Yashima, Kazuo|Tamoto, Akihiro|Hosoda, Kohei|Yamamoto, Sohei|Iwamoto, Taku|Ueda, Naoki|Ikebuchi, Yuichiro|Kawaguchi, Koichiro|Harada, Kenichi|Murawaki, Yoshikazu|Isomoto, Hajime
PMID: 29399338
Journal: Oncotarget. 2017 Dec 19;9(2):2367-2383.
Title: Modified miR-15a has therapeutic potential for improving treatment of advanced stage colorectal cancer through inhibition of BCL2, BMI1, YAP1 and DCLK1.
Author: Fesler, Andrew|Liu, Hua|Ju, Jingfang
PMID: 29416778
Journal: Biomed Pharmacother. 2018 Jul;103:301-307.
Title: DCLK1 plays an important role in colorectal cancer tumorgenesis through the regulation of miR-200c.
Author: Mohammadi, Yasaman|Tavangar, Seyed Mohammad|Saidijam, Massoud|Amini, Razieh|Etemadi, Katayoon|Karimi Dermani, Fatemeh|Najafi, Rezvan
PMID: 29656186
Journal: APMIS. 2018 Jun;126(6):486-493.
Title: Prognostic impact of doublecortin-like kinase 1 expression in locally advanced rectal cancer treated with preoperative chemoradiotherapy.
Author: Harada, Yuzo|Kazama, Shinsuke|Morikawa, Teppei|Emoto, Shigenobu|Murono, Koji|Kaneko, Manabu|Sasaki, Kazuhito|Otani, Kensuke|Nishikawa, Takeshi|Tanaka, Toshiaki|Kiyomatsu, Tomomichi|Kawai, Kazushige|Hata, Keisuke|Nozawa, Hiroaki|Ishihara, Soichiro|Watanabe
PMID: 29924454
Journal: Cancer Lett. 2018 Nov 28;437:13-24.
Title: Montelukast, a CysLT1 receptor antagonist, reduces colon cancer stemness and tumor burden in a mouse xenograft model of human colon cancer.
Author: Bellamkonda, Kishan|Satapathy, Shakti Ranjan|Douglas, Desiree|Chandrashekar, Naveenkumar|Selvanesan, Benson Chellakkan|Liu, Minghui|Savari, Sayeh|Jonsson, Gunilla|Sjolander, Anita
PMID: 30144515
Journal: Onco Targets Ther. 2018 Aug 21;11:5047-5057.
Title: Analysis of the clinical significance of DCLK1(+) colorectal cancer using novel monoclonal antibodies against DCLK1.
Author: Dai, Tianqi|Hu, Yunlong|Lv, Fulian|Ozawa, Tatsuhiko|Sun, Xin|Huang, Jingjing|Han, Xiaojian|Kishi, Hiroyuki|Muraguchi, Atsushi|Jin, Aishun
PMID: 30174443