Primary Site >> Colorectal Cancer
Gene >> DCLK1
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Ref: Anti-tumour activity and toxicity of the new prodrug 9-aminocamptothecin glucuronide (9ACG) in mice. PMID: 12085215 |
Ref: Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice. PMID: 19652364 |
Ref: The synergistic anticancer effect of troglitazone combined with aspirin causes cell cycle arrest and apoptosis in human lung cancer cells. PMID: 19908241 |
Ref: Enhancement of CPT-11 antitumor activity by adenovirus-mediated expression of beta-glucuronidase in tumors. PMID: 21350582 |
Ref: Honokiol in combination with radiation targets notch signaling to inhibit colon cancer stem cells. PMID: 22319203 Ref: Kruppel-like factor 4 regulates intestinal epithelial cell morphology and polarity. PMID: 22384261 Ref: Gastric tumor development in Smad3-deficient mice initiates from forestomach/glandular transition zone along the lesser curvature. PMID: 22411066 Ref: DCLK1 immunoreactivity in colorectal neoplasia. PMID: 22557932 Ref: Momordica charantia Extract Induces Apoptosis in Human Cancer Cells through Caspase- and Mitochondria-Dependent Pathways. PMID: 23091557 |
Ref: Dclk1 distinguishes between tumor and normal stem cells in the intestine. PMID: 23202126 Ref: Methanolic extracts of bitter melon inhibit colon cancer stem cells by affecting energy homeostasis and autophagy. PMID: 23533514 Ref: Doublecortin-like kinase 1 exhibits cancer stem cell-like characteristics in a human colon cancer cell line. PMID: 23592893 |
Ref: Prolactin signaling enhances colon cancer stemness by modulating Notch signaling in a Jak2-STAT3/ERK manner. PMID: 24265293 Ref: The recently suggested intestinal cancer stem cell marker DCLK1 is an epigenetic biomarker for colorectal cancer. PMID: 24384857 Ref: Long-lived intestinal tuft cells serve as colon cancer-initiating cells. PMID: 24487592 Ref: Curcumin promotes autophagic survival of a subset of colon cancer stem cells, which are ablated by DCLK1-siRNA. PMID: 24626093 Ref: CHFR promoter methylation indicates poor prognosis in stage II microsatellite stable colorectal cancer. PMID: 24928946 Ref: Patterns of somatic alterations between matched primary and metastatic colorectal tumors characterized by whole-genome sequencing. PMID: 25066378 Ref: Stress response protein cirp links inflammation and tumorigenesis in colitis-associated cancer. PMID: 25187386 Ref: DCLK1 facilitates intestinal tumor growth via enhancing pluripotency and epithelial mesenchymal transition. PMID: 25211188 |
Ref: The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers. PMID: 24948044 Ref: Methods for detecting circulating cancer stem cells (CCSCs) as a novel approach for diagnosis of colon cancer relapse/metastasis. PMID: 25347154 Ref: Differential reprogramming of isogenic colorectal cancer cells by distinct activating KRAS mutations. PMID: 25599653 Ref: DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma. PMID: 25605241 Ref: Upregulation of circulating cancer stem cell marker, DCLK1 but not Lgr5, in chemoradiotherapy-treated colorectal cancer patients. PMID: 25631749 Ref: Doublecortin-like kinase 1 is elevated serologically in pancreatic ductal adenocarcinoma and widely expressed on circulating tumor cells. PMID: 25723399 Ref: Inflammatory and oncogenic roles of a tumor stem cell marker doublecortin-like kinase (DCLK1) in virus-induced chronic liver diseases. PMID: 25948779 Ref: Ablation of Doublecortin-Like Kinase 1 in the Colonic Epithelium Exacerbates Dextran Sulfate Sodium-Induced Colitis. PMID: 26285154 Ref: Regulation of miRNAs by agents targeting the tumor stem cell markers DCLK1, MSI1, LGR5, and BMI1. PMID: 26366338 Ref: Epigenetic changes and alternate promoter usage by human colon cancers for expressing DCLK1-isoforms: Clinical Implications. PMID: 26447334 |
Ref: Methylation of the DCLK1 promoter region in circulating free DNA and its prognostic value in lung cancer patients. PMID: 26311076 Ref: RNA binding protein RBM3 increases beta-catenin signaling to increase stem cell characteristics in colorectal cancer cells. PMID: 26331352 Ref: A new insight into cancer stem cell markers: Could local and circulating cancer stem cell markers correlate in colorectal cancer? PMID: 26383518 Ref: miR-137 Regulates the Tumorigenicity of Colon Cancer Stem Cells through the Inhibition of DCLK1. PMID: 26747706 Ref: An ornamental plant targets epigenetic signaling to block cancer stem cell-driven colon carcinogenesis. PMID: 26785732 Ref: The eicosanoids leukotriene D4 and prostaglandin E2 promote the tumorigenicity of colon cancer-initiating cells in a xenograft mouse model. PMID: 27388564 Ref: DCLK1 is up-regulated and associated with metastasis and prognosis in colorectal cancer. PMID: 27520310 Ref: Dietary Methyl Donor Depletion Suppresses Intestinal Adenoma Development. PMID: 27530130 Ref: Epigenetic regulation of human DCLK-1 gene during colon-carcinogenesis: clinical and mechanistic implications. PMID: 27777940 Ref: Evaluation of circulating cellular DCLK1 protein, as the most promising colorectal cancer stem cell marker, using immunoassay based methods. PMID: 27802206 |
Ref: Identification of MSX1 and DCLK1 as mRNA Biomarkers for Colorectal Cancer Detection Through DNA Methylation Information. PMID: 27966796 Ref: Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells. PMID: 28148261 Ref: A novel antibody against cancer stem cell biomarker, DCLK1-S, is potentially useful for assessing colon cancer risk after screening colonoscopy. PMID: 28414327 Ref: FOXD3 Regulates CSC Marker, DCLK1-S, and Invasive Potential: Prognostic Implications in Colon Cancer. PMID: 28851816 Ref: SATB2/beta-catenin/TCF-LEF pathway induces cellular transformation by generating cancer stem cells in colorectal cancer. PMID: 28887549 Ref: Commensal-infected macrophages induce dedifferentiation and reprogramming of epithelial cells during colorectal carcinogenesis. PMID: 29254234 Ref: Development of pH-Sensitive Cationic PEGylated Solid Lipid Nanoparticles for Selective Cancer-Targeted Therapy. PMID: 29377649 |
Ref: DCLK1 promotes epithelial-mesenchymal transition via the PI3K/Akt/NF-kappaB pathway in colorectal cancer. PMID: 29277893 Ref: Expression of doublecortin and CaM kinase-like-1 protein in serrated neoplasia of the colorectum. PMID: 29399338 Ref: Modified miR-15a has therapeutic potential for improving treatment of advanced stage colorectal cancer through inhibition of BCL2, BMI1, YAP1 and DCLK1. PMID: 29416778 Ref: DCLK1 plays an important role in colorectal cancer tumorgenesis through the regulation of miR-200c. PMID: 29656186 Ref: Prognostic impact of doublecortin-like kinase 1 expression in locally advanced rectal cancer treated with preoperative chemoradiotherapy. PMID: 29924454 Ref: Montelukast, a CysLT1 receptor antagonist, reduces colon cancer stemness and tumor burden in a mouse xenograft model of human colon cancer. PMID: 30144515 Ref: Analysis of the clinical significance of DCLK1(+) colorectal cancer using novel monoclonal antibodies against DCLK1. PMID: 30174443 |