Literatures

Primary Site >> Liver Cancer

Gene >> CYP3A4

1.
Journal:	Int J Radiat Oncol Biol Phys. 1994 May 15;29(2):277-83.
Title:	Expression of xenobiotic-metabolizing enzymes by primary and secondary hepatic tumors in man.
Author:	Philip, P A\|Kaklamanis, L\|Ryley, N\|Stratford, I\|Wolf, R\|Harris, A\|Carmichael, J
PMID:	8195019

2.
Journal:	Carcinogenesis. 1995 Jul;16(7):1549-55.
Title:	Cytochromes P450 in cynomolgus monkeys mutagenically activate 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) but not 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).
Author:	Sadrieh, N\|Snyderwine, E G
PMID:	7614688

3.
Journal:	Cancer. 1996 Apr 15;77(8):1427-33.
Title:	Urinary 6 beta-hydroxycortisol excretion in Hong Kong Chinese patients with hepatocellular carcinoma and other chronic liver diseases.
Author:	Ng, M C\|Young, R P\|Critchley, J A\|Leung, N W\|Lau, J W\|Li, A K
PMID:	8608525

4.
Journal:	Mutat Res. 1997 May 12;376(1-2):203-10.
Title:	Metabolism of food-derived heterocyclic amines in nonhuman primates.
Author:	Snyderwine, E G\|Turesky, R J\|Turteltaub, K W\|Davis, C D\|Sadrieh, N\|Schut, H A\|Nagao, M\|Sugimura, T\|Thorgeirsson, U P\|Adamson, R H\|Thorgeirsson, S S
PMID:	9202757

5.
Journal:	Carcinogenesis. 1997 Jul;18(7):1291-7.
Title:	Aflatoxin B1-induced DNA adduct formation and p53 mutations in CYP450-expressing human liver cell lines.
Author:	Mace, K\|Aguilar, F\|Wang, J S\|Vautravers, P\|Gomez-Lechon, M\|Gonzalez, F J\|Groopman, J\|Harris, C C\|Pfeifer, A M
PMID:	9230270

6.
Journal:	Biochem Pharmacol. 1999 Apr 15;57(8):951-4.
Title:	Decrease in hepatic cytochrome P450 after interleukin-2 immunotherapy.
Author:	Elkahwaji, J\|Robin, M A\|Berson, A\|Tinel, M\|Letteron, P\|Labbe, G\|Beaune, P\|Elias, D\|Rougier, P\|Escudier, B\|Duvillard, P\|Pessayre, D
PMID:	10086330

7.
Journal:	Cancer Res. 1999 Oct 1;59(19):4990-6.
Title:	Identification and characterization of genes associated with human hepatocellular carcinogenesis.
Author:	Kondoh, N\|Wakatsuki, T\|Ryo, A\|Hada, A\|Aihara, T\|Horiuchi, S\|Goseki, N\|Matsubara, O\|Takenaka, K\|Shichita, M\|Tanaka, K\|Shuda, M\|Yamamoto, M
PMID:	10519413

8.
Journal:	Drug Metab Dispos. 2000 Jan;28(1):96-101.
Title:	Effect of the adrenal 11-beta-hydroxylase inhibitor metyrapone on human hepatic cytochrome P-450 expression: induction of cytochrome P-450 3A4.
Author:	Harvey, J L\|Paine, A J\|Maurel, P\|Wright, M C
PMID:	10611146

9.
Journal:	Int J Cancer. 2000 Apr 1;86(1):1-7.
Title:	Environmental and genetic determinants of aflatoxin-albumin adducts in the Gambia.
Author:	Wild, C P\|Yin, F\|Turner, P C\|Chemin, I\|Chapot, B\|Mendy, M\|Whittle, H\|Kirk, G D\|Hall, A J
PMID:	10728587

10.
Journal:	Ann N Y Acad Sci. 2000;922:260-73.
Title:	DX-8951f: summary of phase I clinical trials.
Author:	De Jager, R\|Cheverton, P\|Tamanoi, K\|Coyle, J\|Ducharme, M\|Sakamoto, N\|Satomi, M\|Suzuki, M
PMID:	11193901

11.
Journal:	Biomarkers. 2000;5(4):295-306.
Title:	Expression of cytochrome P450 1A1/2 and 3A4 in liver tissues of hepatocellular carcinoma cases and controls from Taiwan and their relationship to hepatitis B virus and aflatoxin B1-and 4-aminobiphenyl-DNA adducts.
Author:	Zhang, Y J\|Chen, S\|Tsai, W Y\|Ahsan, H\|Lunn, R M\|Wang, L\|Chen, C J\|Santella, R M
PMID:	23885982

12.
Journal:	Life Sci. 2003 May 30;73(2):141-9.
Title:	Induction of CYP3A4 by 1alpha,25-dyhydroxyvitamin D3 in HepG2 cells.
Author:	Elizondo, Guillermo\|Medina-Diaz, Irma M
PMID:	12738030

13.
Journal:	Curr Drug Metab. 2003 Jun;4(3):223-39.
Title:	Tamoxifen: is it safe? Comparison of activation and detoxication mechanisms in rodents and in humans.
Author:	White, I N H
PMID:	12769667

14.
Journal:	Eur J Pharmacol. 2003 Apr 11;466(1-2):7-12.
Title:	Differential drug-induced mRNA expression of human CYP3A4 compared to CYP3A5, CYP3A7 and CYP3A43.
Author:	Krusekopf, Solveigh\|Roots, Ivar\|Kleeberg, Ullrich
PMID:	12679136

15.
Journal:	Hepatology. 2003 Mar;37(3):665-73.
Title:	CYP3A4 inducible model for in vitro analysis of human drug metabolism using a bioartificial liver.
Author:	Iwahori, Tohru\|Matsuura, Tomokazu\|Maehashi, Haruka\|Sugo, Ken\|Saito, Masaya\|Hosokawa, Masakiyo\|Chiba, Kan\|Masaki, Takahiro\|Aizaki, Hideki\|Ohkawa, Kiyoshi\|Suzuki, Tetsuro
PMID:	12601364

16.
Journal:	Curr Drug Metab. 2004 Jun;5(3):211-24.
Title:	Cytochrome P450 gene polymorphism and cancer.
Author:	Agundez, Jose A G
PMID:	15180491

17.
Journal:	Pharmacogenetics. 2004 Oct;14(10):691-700.
Title:	Increased levels of aflatoxin-albumin adducts are associated with CYP3A5 polymorphisms in The Gambia, West Africa.
Author:	Wojnowski, Leszek\|Turner, Paul C\|Pedersen, Bonnie\|Hustert, Elisabeth\|Brockmoller, Jurgen\|Mendy, Maimuna\|Whittle, Hilton C\|Kirk, Greg\|Wild, Christopher P
PMID:	15454734

18.
Journal:	Clin Cancer Res. 2005 Feb 15;11(4):1608-17.
Title:	Formation and antitumor activity of PNU-159682, a major metabolite of nemorubicin in human liver microsomes.
Author:	Quintieri, Luigi\|Geroni, Cristina\|Fantin, Marianna\|Battaglia, Rosangela\|Rosato, Antonio\|Speed, William\|Zanovello, Paola\|Floreani, Maura
PMID:	15746066

19.
Journal:	Clin Cancer Res. 2005 Sep 1;11(17):6359-69.
Title:	Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents.
Author:	Mani, Sridhar\|Huang, Haiyan\|Sundarababu, Sumathy\|Liu, Wenjing\|Kalpana, Ganjam\|Smith, Amos B\|Horwitz, Susan B
PMID:	16144941

20.
Journal:	Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku. 2005;(123):68-72.
Title:	[Network for the collection and distribution of Japanese liver tissues resected surgically for drug development and research use].
Author:	Sunouchi, Momoko\|Sakemi, Kazue\|Kubota, Kei-ichi\|Kita, Junji\|Kamikawa, Yuichiro\|Uchida, Kohsuke\|Miura, Shin-ichi\|Shigehara, Eiji\|Fujioka, Hiroyuki\|Ohno, Yasuo
PMID:	16541756

21.
Journal:	Pharmacogenet Genomics. 2006 Jun;16(6):415-27.
Title:	Increased CYP3A4 copy number in TONG/HCC cells but not in DNA from other humans.
Author:	Lamba, Jatinder K\|Chen, Xin\|Lan, Lu-Bin\|Kim, Jin Woo\|Wei Wang, Xin\|Relling, Mary V\|Kazuto, Yasuda\|Watkins, Paul B\|Strom, Stephen\|Sun, Daxi\|Schuetz, John D\|Schuetz, Erin G
PMID:	16708050

22.
Journal:	J Med Chem. 2006 Dec 28;49(26):7711-20.
Title:	Synthesis and characterization of a novel liver-targeted prodrug of cytosine-1-beta-D-arabinofuranoside monophosphate for the treatment of hepatocellular carcinoma.
Author:	Boyer, Serge H\|Sun, Zhili\|Jiang, Hongjian\|Esterbrook, Julie\|Gomez-Galeno, Jorge E\|Craigo, William\|Reddy, K Raja\|Ugarkar, Bheemarao G\|MacKenna, Deidre A\|Erion, Mark D
PMID:	17181153

23.
Journal:	BMC Cancer. 2007 Jul 2;7:118.
Title:	Genetic variability in CYP3A4 and CYP3A5 in primary liver, gastric and colorectal cancer patients.
Author:	Gervasini, Guillermo\|Garcia-Martin, Elena\|Ladero, Jose M\|Pizarro, Rosa\|Sastre, Javier\|Martinez, Carmen\|Garcia, Monserrat\|Diaz-Rubio, Manuel\|Agundez, Jose A G
PMID:	17605821

24.
Journal:	J Biol Chem. 2008 Nov 7;283(45):30650-7.
Title:	Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells.
Author:	Lin, Wenwei\|Wu, Jing\|Dong, Hanqing\|Bouck, David\|Zeng, Fu-Yue\|Chen, Taosheng
PMID:	18784074

25.
Journal:	Basic Clin Pharmacol Toxicol. 2008 Apr;102(4):399-407.
Title:	Chemosensitivity determinants of irinotecan hydrochloride in hepatocellular carcinoma cell lines.
Author:	Takahata, Takenori\|Ookawa, Keizou\|Suto, Koji\|Tanaka, Masanori\|Yano, Hirohisa\|Nakashima, Osamu\|Kojiro, Masamichi\|Tamura, Yoshihiro\|Tateishi, Tomonori\|Sakata, Yuh\|Fukuda, Shinsaku
PMID:	18248513

26.
Journal:	Clin Chim Acta. 2009 May;403(1-2):142-4.
Title:	The effects of splicing variant of PXR PAR-2 on CYP3A4 and MDR1 mRNA expressions.
Author:	Liu, Yan\|Ji, Wei\|Yin, You\|Fan, Lan\|Zhang, Jian\|Yun, Huang\|Wang, Nianci\|Li, Qing\|Wei, Zhang\|Ouyang, Dongshen\|Zhou, Hong-Hao
PMID:	19232333

27.
Journal:	Pathol Res Pract. 2009;205(10):716-25.
Title:	Expression of xenobiotic and steroid hormone metabolizing enzymes in hepatocellular tumors of the non-cirrhotic liver.
Author:	Haas, Susanne\|Merkelbach-Bruse, Sabine\|Justenhoven, Christina\|Brauch, Hiltrud\|Fischer, Hans-Peter
PMID:	19596526

28.
Journal:	Stem Cells Dev. 2010 Aug;19(8):1277-84.
Title:	Human liver progenitor cell lines are readily established from non-tumorous tissue adjacent to hepatocellular carcinoma.
Author:	Zhang, Aibin\|London, Roslyn\|Schulz, Frederik Michael\|Giguere-Simmonds, Philippe Wilfred Roger\|Delriviere, Luc\|Chandraratana, Harsha\|Hardy, Kathy\|Zheng, Shusen\|Olynyk, John K\|Yeoh, George
PMID:	19874130

29.
Journal:	Drug Metab Dispos. 2010 Sep;38(9):1411-6.
Title:	Protein phosphatase 2Cbetal regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells.
Author:	Pondugula, Satyanarayana R\|Tong, Alexander A\|Wu, Jing\|Cui, Jimmy\|Chen, Taosheng
PMID:	20538721

30.
Journal:	Avian Pathol. 2010 Aug;39(4):279-85.
Title:	The role of selected cytochrome P450 enzymes on the bioactivation of aflatoxin B1 by duck liver microsomes.
Author:	Diaz, Gonzalo J\|Murcia, Hansen W\|Cepeda, Sandra M\|Boermans, Herman J
PMID:	20706884

31.
Journal:	Drug Metab Dispos. 2010 Dec;38(12):2226-31.
Title:	The Chinese herbal medicine Sophora flavescens activates pregnane X receptor.
Author:	Wang, Laiyou\|Li, Feng\|Lu, Jie\|Li, Guodong\|Li, Dan\|Zhong, Xiao-bo\|Guo, Grace L\|Ma, Xiaochao
PMID:	20736322

32.
Journal:	Invest New Drugs. 2011 Dec;29(6):1511-4.
Title:	Pharmacokinetic interaction involving sorafenib and the calcium-channel blocker felodipine in a patient with hepatocellular carcinoma.
Author:	Gomo, Charline\|Coriat, Romain\|Faivre, Lionel\|Mir, Olivier\|Ropert, Stanislas\|Billemont, Bertrand\|Dauphin, Alain\|Tod, Michel\|Goldwasser, Francois\|Blanchet, Benoit
PMID:	20706860

33.
Journal:	J Toxicol Sci. 2011 Oct;36(5):625-33.
Title:	Expression of albumin and cytochrome P450 enzymes in HepG2 cells cultured with a nanotechnology-based culture plate with microfabricated scaffold.
Author:	Nakamura, Kazuaki\|Kato, Natsuko\|Aizawa, Kazuko\|Mizutani, Reiko\|Yamauchi, Junji\|Tanoue, Akito
PMID:	22008537

34.
Journal:	Eur J Pharmacol. 2011 Nov 1;669(1-3):45-50.
Title:	Construction and characterization of hepatocyte nuclear factor HNF4alpha1 over-expressing cell line derived from human hepatoma HepG2 cells.
Author:	Novotna, Aneta\|Doricakova, Aneta\|Vrzal, Radim\|Pavek, Petr\|Dvorak, Zdenek
PMID:	21871880

35.
Journal:	Postepy Hig Med Dosw (Online). 2011 Jun 17;65:367-76.
Title:	[Expression systems of cytochrome P450 proteins in studies of drug metabolism in vitro].
Author:	Pawlowska, Monika\|Augustin, Ewa
PMID:	21734321

36.
Journal:	Drug Metab Pharmacokinet. 2011;26(4):407-15. Epub 2011 May 12.
Title:	Overexpression of CYP3A4, but not of CYP2D6, promotes hypoxic response and cell growth of Hep3B cells.
Author:	Oguro, Ami\|Sakamoto, Koichi\|Funae, Yoshihiko\|Imaoka, Susumu
PMID:	21566342

37.
Journal:	Clin Cancer Res. 2011 May 15;17(10):3170-80.
Title:	Extrahepatic cancer suppresses nuclear receptor-regulated drug metabolism.
Author:	Kacevska, Marina\|Downes, Michael R\|Sharma, Rohini\|Evans, Ronald M\|Clarke, Stephen J\|Liddle, Christopher\|Robertson, Graham R
PMID:	21498392

38.
Journal:	Br J Clin Pharmacol. 2011 Aug;72(2):294-305.
Title:	Population pharmacokinetic analysis of sorafenib in patients with solid tumours.
Author:	Jain, Lokesh\|Woo, Sukyung\|Gardner, Erin R\|Dahut, William L\|Kohn, Elise C\|Kummar, Shivaani\|Mould, Diane R\|Giaccone, Giuseppe\|Yarchoan, Robert\|Venitz, Jurgen\|Figg, William D
PMID:	21392074

39.
Journal:	Biochim Biophys Acta. 2011 Jan;1814(1):161-7.
Title:	Whole-cell biotransformation assay for investigation of the human drug metabolizing enzyme CYP3A7.
Author:	Neunzig, Ina\|Dragan, Calin-Aurel\|Widjaja, Maria\|Schwaninger, Andrea E\|Peters, Frank T\|Maurer, Hans H\|Bureik, Matthias
PMID:	20637317

40.
Journal:	Biomed Pharmacother. 2012 Dec;66(8):612-6.
Title:	STAT3 & Cytochrome P450 2C9: a novel signaling pathway in liver cancer stem cells.
Author:	Myung, Sun Jung\|Yoon, Jung-Hwan\|Yu, Su Jong
PMID:	23089473

41.
Journal:	PLoS One. 2012;7(9):e45063.
Title:	Astemizole synergizes calcitriol antiproliferative activity by inhibiting CYP24A1 and upregulating VDR: a novel approach for breast cancer therapy.
Author:	Garcia-Quiroz, Janice\|Garcia-Becerra, Rocio\|Barrera, David\|Santos, Nancy\|Avila, Euclides\|Ordaz-Rosado, David\|Rivas-Suarez, Mariana\|Halhali, Ali\|Rodriguez, Pamela\|Gamboa-Dominguez, Armando\|Medina-Franco, Heriberto\|Camacho, Javier\|Larrea, Fernando\|Diaz, Lor
PMID:	22984610

42.
Journal:	Toxicology. 2012 Sep 28;299(2-3):69-79.
Title:	Dietary modulation of the biotransformation and genotoxicity of aflatoxin B(1).
Author:	Gross-Steinmeyer, Kerstin\|Eaton, David L
PMID:	22640941

43.
Journal:	J Cell Biochem. 2012 Jan;113(1):19-30.
Title:	A simple and economical route to generate functional hepatocyte-like cells from hESCs and their application in evaluating alcohol induced liver damage.
Author:	Pal, Rajarshi\|Mamidi, Murali Krishna\|Das, Anjan Kumar\|Gupta, Pawan Kumar\|Bhonde, Ramesh
PMID:	21956183

44.
Journal:	Drug Metab Pharmacokinet. 2012;27(5):478-85. Epub 2012 Mar 6.
Title:	Increased expression of drug-metabolizing enzymes in human hepatocarcinoma FLC-4 cells cultured on micro-space cell culture plates.
Author:	Kobayashi, Kaoru\|Yoshida, Akane\|Ejiri, Yoko\|Takagi, Sachiko\|Mimura, Hanaka\|Hosoda, Masaya\|Matsuura, Tomokazu\|Chiba, Kan
PMID:	22447115

45.
Journal:	Acta Pharmacol Sin. 2013 Nov;34(11):1437-48.
Title:	Pharmacokinetic evaluation of the anticancer prodrug simmitecan in different experimental animals.
Author:	Hu, Zhe-yi\|Li, Xiu-xue\|Du, Fei-fei\|Yang, Jun-ling\|Niu, Wei\|Xu, Fang\|Wang, Feng-qing\|Li, Chuan\|Sun, Yan
PMID:	24056706

46.
Journal:	Dig Liver Dis. 2013 Dec;45(12):1041-8.
Title:	Hepatitis B virus X protein co-activates pregnane X receptor to induce the cytochrome P450 3A4 enzyme, a potential implication in hepatocarcinogenesis.
Author:	Niu, Yongdong\|Wu, Zheng\|Shen, Qiujin\|Song, Jin\|Luo, Qin\|You, Haiyan\|Shi, Ganggang\|Qin, Wenxin
PMID:	23891548

47.
Journal:	Curr Drug Saf. 2013 Apr;8(2):148-52.
Title:	Severe hypoglycemia due to possible interaction between glibenclamide and sorafenib in a patient with hepatocellular carcinoma.
Author:	Holstein, Andreas\|Kovacs, Peter\|Beil, Winfried
PMID:	23845193

48.
Journal:	Acta Pharmacol Sin. 2013 Sep;34(9):1237-42.
Title:	Pungent ginger components modulates human cytochrome P450 enzymes in vitro.
Author:	Li, Mian\|Chen, Pei-zhan\|Yue, Qing-xi\|Li, Jing-quan\|Chu, Rui-ai\|Zhang, Wei\|Wang, Hui
PMID:	23770984

49.
Journal:	Cancer Chemother Pharmacol. 2013 Jul;72(1):269-72.
Title:	Pharmacokinetic interaction between sorafenib and prednisolone in a patient with hepatocellular carcinoma.
Author:	Noda, Satoshi\|Shioya, Makoto\|Hira, Daiki\|Fujiyama, Yoshihide\|Morita, Shin-ya\|Terada, Tomohiro
PMID:	23673446

50.
Journal:	Drug Metab Pharmacokinet. 2013;28(3):265-8. Epub 2012 Dec 11.
Title:	Cytotoxic effects of benzbromarone and its 1'-hydroxy metabolite in human hepatocarcinoma FLC4 cells cultured on micro-space cell culture plates.
Author:	Kobayashi, Kaoru\|Kajiwara, Eri\|Ishikawa, Masayuki\|Mimura, Hanaka\|Oka, Hidenobu\|Ejiri, Yoko\|Hosoda, Masaya\|Chiba, Kan
PMID:	23229783

51.
Journal:	J Ethnopharmacol. 2013 Jan 30;145(2):670-5.
Title:	Evaluation of Ginkgo biloba extract as an activator of human glucocorticoid receptor.
Author:	Lau, Aik Jiang\|Yang, Guixiang\|Rajaraman, Ganesh\|Baucom, Christie C\|Chang, Thomas K H
PMID:	23220176

52.
Journal:	Invest New Drugs. 2013 Jun;31(3):724-33.
Title:	Phase I and pharmacokinetic study of IV vinflunine in cancer patients with liver dysfunction.
Author:	Delord, J P\|Ravaud, A\|Bennouna, J\|Fumoleau, P\|Favrel, S\|Pinel, M C\|Ferre, P\|Saliba, F
PMID:	22996801

53.
Journal:	J Ethnopharmacol. 2014;151(1):210-7.
Title:	Marsdenia tenacissima extract inhibits gefitinib metabolism in vitro by interfering with human hepatic CYP3A4 and CYP2D6 enzymes.
Author:	Han, Shu-Yan\|Zhao, Hai-Yu\|Zhou, Ning\|Zhou, Fei\|Li, Ping-Ping
PMID:	24157377

54.
Journal:	Xenobiotica. 2014 Jul;44(7):606-14.
Title:	In vitro inhibition of human liver cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzymes by rose bengal: system-dependent effects on inhibitory potential.
Author:	Kazmi, Faraz\|Haupt, Lois J\|Horkman, Jennifer R\|Smith, Brian D\|Buckley, David B\|Wachter, Eric A\|Singer, Jamie M
PMID:	24405273

55.
Journal:	PLoS One. 2014 May 5;9(5):e96664.
Title:	Sorafenib metabolism is significantly altered in the liver tumor tissue of hepatocellular carcinoma patient.
Author:	Ye, Ling\|Yang, Xiaoshan\|Guo, Enshuang\|Chen, Weiying\|Lu, Linlin\|Wang, Ying\|Peng, Xiaojuan\|Yan, Tongmeng\|Zhou, Fuyan\|Liu, Zhongqiu
PMID:	24797816

56.
Journal:	Cell Physiol Biochem. 2014;33(5):1400-10.
Title:	Short-term effects of oral administration of Pistacia lentiscus oil on tissue-specific toxicity and drug metabolizing enzymes in mice.
Author:	Attoub, Samir\|Karam, Sherif M\|Nemmar, Abderrahim\|Arafat, Kholoud\|John, Annie\|Al-Dhaheri, Wafa\|Al Sultan, Mahmood Ahmed\|Raza, Haider
PMID:	24853661

57.
Journal:	Cell Biol Int. 2014 Nov;38(11):1291-303.
Title:	CYP3A4-dependent cellular response does not relate to CYP3A4-catalysed metabolites of C-1748 and C-1305 acridine antitumor agents in HepG2 cells.
Author:	Augustin, Ewa\|Niemira, Magdalena\|Holownia, Adam\|Mazerska, Zofia
PMID:	24890801

58.
Journal:	World J Gastroenterol. 2014 Jul 14;20(26):8681-90.
Title:	Expression of P450 and nuclear receptors in normal and end-stage Chinese livers.
Author:	Chen, Hong\|Shen, Zhong-Yang\|Xu, Wang\|Fan, Tie-Yan\|Li, Jun\|Lu, Yuan-Fu\|Cheng, Ming-Liang\|Liu, Jie
PMID:	25024626

59.
Journal:	PLoS One. 2014 Aug 7;9(8):e104123.
Title:	Dual-color fluorescence imaging to monitor CYP3A4 and CYP3A7 expression in human hepatic carcinoma HepG2 and HepaRG cells.
Author:	Tsuji, Saori\|Kawamura, Fumihiko\|Kubiura, Musashi\|Hayashi, Ayaka\|Ohbayashi, Tetsuya\|Kazuki, Yasuhiro\|Chesne, Christophe\|Oshimura, Mitsuo\|Tada, Masako
PMID:	25101946

60.
Journal:	Afr Health Sci. 2015 Jun;15(2):590-3.
Title:	Drug-drug interation prediction between ketoconazole and anti-liver cancer drug Gomisin G.
Author:	Xiaoyang, Liu\|Chenming, Ni\|Chengqing, Li\|Tao, Liu
PMID:	26124807

61.
Journal:	Cancer Res. 2015 Jun 15;75(12):2510-9.
Title:	Effects of Sorafenib Dose on Acquired Reversible Resistance and Toxicity in Hepatocellular Carcinoma.
Author:	Kuczynski, Elizabeth A\|Lee, Christina R\|Man, Shan\|Chen, Eric\|Kerbel, Robert S
PMID:	25908587

62.
Journal:	Pharm Res. 2015 Mar;32(3):1141-57.
Title:	Significantly decreased and more variable expression of major CYPs and UGTs in liver microsomes prepared from HBV-positive human hepatocellular carcinoma and matched pericarcinomatous tissues determined using an isotope label-free UPLC-MS/MS method.
Author:	Yan, Tongmeng\|Gao, Song\|Peng, Xiaojuan\|Shi, Jian\|Xie, Cong\|Li, Qiang\|Lu, Linlin\|Wang, Ying\|Zhou, Fuyuan\|Liu, Zhongqiu\|Hu, Ming
PMID:	25288013

63.
Journal:	Drug Metab Pharmacokinet. 2015 Feb;30(1):105-10.
Title:	Effects of cytokines on CYP3A4 expression and reversal of the effects by anti-cytokine agents in the three-dimensionally cultured human hepatoma cell line FLC-4.
Author:	Mimura, Hanaka\|Kobayashi, Kaoru\|Xu, Linxiaoqing\|Hashimoto, Mari\|Ejiri, Yoko\|Hosoda, Masaya\|Chiba, Kan
PMID:	25760537

64.
Journal:	Oncotarget. 2016 Aug 2;7(31):50612-50623.
Title:	Significant change of cytochrome P450s activities in patients with hepatocellular carcinoma.
Author:	Zhou, Jun\|Wen, Qiang\|Li, Sai-Fei\|Zhang, Yun-Fei\|Gao, Na\|Tian, Xin\|Fang, Yan\|Gao, Jie\|Cui, Ming-Zhu\|He, Xiao-Pei\|Jia, Lin-Jing\|Jin, Han\|Qiao, Hai-Ling
PMID:	27203676

65.
Journal:	Sci Rep. 2016 Jun 17;6:28178.
Title:	Long-term exposure to abnormal glucose levels alters drug metabolism pathways and insulin sensitivity in primary human hepatocytes.
Author:	Davidson, Matthew D\|Ballinger, Kimberly R\|Khetani, Salman R
PMID:	27312339

66.
Journal:	Eur J Histochem. 2016 Apr 11;60(2):2614.
Title:	Immunohistochemical markers of CYP3A4 and CYP3A7: a new tool towards personalized pharmacotherapy of hepatocellular carcinoma.
Author:	Fanni, D\|Manchia, M\|Lai, F\|Gerosa, C\|Ambu, R\|Faa, G
PMID:	27349315

67.
Journal:	Acta Pharm. 2016 Dec 1;66(4):491-502.
Title:	Modulatory effects of rutin on the expression of cytochrome P450s and antioxidant enzymes in human hepatoma cells.
Author:	Karakurt, Sedar
PMID:	27749250

68.
Journal:	Oncol Lett. 2017 Mar;13(3):1264-1268.
Title:	Proliferation of sphere-forming hepatocellular carcinoma cells is suppressed in a medium without glucose and arginine, but with galactose and ornithine.
Author:	Tomizawa, Minoru\|Shinozaki, Fuminobu\|Motoyoshi, Yasufumi\|Sugiyama, Takao\|Yamamoto, Shigenori\|Ishige, Naoki
PMID:	28454244

69.
Journal:	Cancer Genomics Proteomics. 2017 Nov-Dec;14(6):445-453.
Title:	CYP3A4 Gene Is a Novel Biomarker for Predicting a Poor Prognosis in Hepatocellular Carcinoma.
Author:	Ashida, Ryo\|Okamura, Yukiyasu\|Ohshima, Keiichi\|Kakuda, Yuko\|Uesaka, Katsuhiko\|Sugiura, Teiichi\|Ito, Takaaki\|Yamamoto, Yusuke\|Sugino, Takashi\|Urakami, Kenichi\|Kusuhara, Masatoshi\|Yamaguchi, Ken
PMID:	29109094

70.
Journal:	Oncotarget. 2017 Jul 6;8(34):57109-57120.
Title:	Oxidative stress mediates an increased formation of vascular endothelial growth factor in human hepatocarcinoma cells exposed to erlotinib.
Author:	Rohr-Udilova, Nataliya\|Klinglmuller, Florian\|Seif, Martha\|Hayden, Hubert\|Bilban, Martin\|Pinter, Matthias\|Stolze, Klaus\|Sieghart, Wolfgang\|Peck-Radosavljevic, Markus\|Trauner, Michael
PMID:	28915658

71.
Journal:	Oncologist. 2017 May;22(5):505-e49.
Title:	A Phase Ib Study of Sorafenib (BAY 43-9006) in Patients with Kaposi Sarcoma.
Author:	Uldrick, Thomas S\|Goncalves, Priscila H\|Wyvill, Kathleen M\|Peer, Cody J\|Bernstein, Wendy\|Aleman, Karen\|Polizzotto, Mark N\|Venzon, David\|Steinberg, Seth M\|Marshall, Vickie\|Whitby, Denise\|Little, Richard F\|Wright, John J\|Rudek, Michelle A\|Figg, William D\|Ya
PMID:	28341759

72.
Journal:	Environ Pollut. 2017 Jun;225:610-619.
Title:	Altered cellular metabolism of HepG2 cells caused by microcystin-LR.
Author:	Ma, Junguo\|Feng, Yiyi\|Jiang, Siyu\|Li, Xiaoyu
PMID:	28336091

73.
Journal:	Phytomedicine. 2017 Mar 15;26:1-10.
Title:	Comprehensive assessment of Cucurbitacin E related hepatotoxicity and drug-drug interactions involving CYP3A and P-glycoprotein.
Author:	Lu, Jian\|Zhang, Yuanjin\|Sun, Min\|Liu, Mingyao\|Wang, Xin
PMID:	28257659

74.
Journal:	Basic Clin Pharmacol Toxicol. 2017 Oct;121(4):334-341.
Title:	Cis-Nerolidol Induces Endoplasmic Reticulum Stress and Cell Death in Human Hepatocellular Carcinoma Cells through Extensive CYP2C19 and CYP1A2 Oxidation.
Author:	Biazi, Bruna Isabela\|Zanetti, Thalita Alves\|Baranoski, Adrivanio\|Corveloni, Amanda Cristina\|Mantovani, Mario Sergio
PMID:	28256105

75.
Journal:	Drug Metab Pers Ther. 2017 Mar 1;32(1):59-65.
Title:	Cytotoxicity and cytochrome P450 inhibitory activities of Clinacanthus nutans.
Author:	Quah, Suk Yen\|Chin, Jin Han\|Akowuah, Gabriel Akyirem\|Khalivulla, Shaik Ibrahim\|Yeong, Siew Wei\|Sabu, Mandumpal Chacko
PMID:	28253196

76.
Journal:	Invest New Drugs. 2018 Jun;36(3):513-516.
Title:	Pazopanib-related tumor lysis syndrome in metastatic clear cell renal cell carcinoma: a case report.
Author:	van Kalleveen, Michael W\|Walraven, Maudy\|Hendriks, Mathijs P
PMID:	29464464

77.
Journal:	Eur J Med Chem. 2018 May 10;151:723-739.
Title:	Novel hydrazide-hydrazone and amide substituted coumarin derivatives: Synthesis, cytotoxicity screening, microarray, radiolabeling and in vivo pharmacokinetic studies.
Author:	Nasr, Tamer\|Bondock, Samir\|Rashed, Hassan M\|Fayad, Walid\|Youns, Mahmoud\|Sakr, Tamer M
PMID:	29665526

78.
Journal:	Oncotarget. 2018 Apr 24;9(31):22058-22068.
Title:	The down-regulation of the CYP2C19 gene is associated with aggressive tumor potential and the poorer recurrence-free survival of hepatocellular carcinoma.
Author:	Ashida, Ryo\|Okamura, Yukiyasu\|Ohshima, Keiichi\|Kakuda, Yuko\|Uesaka, Katsuhiko\|Sugiura, Teiichi\|Ito, Takaaki\|Yamamoto, Yusuke\|Sugino, Takashi\|Urakami, Kenichi\|Kusuhara, Masatoshi\|Yamaguchi, Ken
PMID:	29774122

79.
Journal:	Cancer Manag Res. 2018 Jun 25;10:1713-1726.
Title:	The prognostic value of differentially expressed CYP3A subfamily members for hepatocellular carcinoma.
Author:	Yu, Tingdong\|Wang, Xiangkun\|Zhu, Guangzhi\|Han, Chuangye\|Su, Hao\|Liao, Xiwen\|Yang, Chengkun\|Qin, Wei\|Huang, Ketuan\|Peng, Tao
PMID:	29983591

80.
Journal:	Drug Metab Lett. 2018 Jul 9. pii: DML-EPUB-91604.
Title:	Genistein affects expression of cytochrome P450 (CYP450) genes in hepatocellular carcinoma (HEPG2/C3A) cell line.
Author:	Lepri, Sandra Regina\|Sartori, Daniele\|Semprebon, Simone Cristine\|Baranoski, Adrivanio\|Coatti, Giuliana Castello\|Mantovani, Mario Sergio
PMID:	29984664

81.
Journal:	Biomed Res Int. 2018 Jul 25;2018:5859415.
Title:	Downregulation of CYP2A6 and CYP2C8 in Tumor Tissues Is Linked to Worse Overall Survival and Recurrence-Free Survival from Hepatocellular Carcinoma.
Author:	Ren, Xiaojing\|Ji, Yuanyuan\|Jiang, Xuhua\|Qi, Xun
PMID:	30148168

82.
Journal:	Biomed Environ Sci. 2018 Aug;31(8):586-595.
Title:	Specific CYP450 Genotypes in the Chinese Population Affect Sorafenib Toxicity in HBV/HCV-associated Hepatocellular Carcinoma Patients.
Author:	Guo, Xing Gang\|Wang, Zhi Heng\|Dong, Wei\|He, Xu Dong\|Liu, Fu Chen\|Liu, Hui
PMID:	30231963

83.
Journal:	Cancer Manag Res. 2018 Oct 10;10:4421-4438.
Title:	LINE-1 ORF-1p enhances the transcription factor activity of pregnenolone X receptor and promotes sorafenib resistance in hepatocellular carcinoma cells.
Author:	Chen, Yan\|Zeng, Qinglei\|Liu, Xiufang\|Fu, Junliang\|Zeng, Zhen\|Zhao, Zhiqin\|Liu, Ze\|Bai, Wenlin\|Dong, Zheng\|Liu, Hongjin\|Lu, Xiaoxia\|Zhu, Yunfeng\|Lu, Yinying
PMID:	30349375