Primary Site >> Liver Cancer
Gene >> CYP3A4
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Ref: Expression of xenobiotic-metabolizing enzymes by primary and secondary hepatic tumors in man. PMID: 8195019 |
Ref: Cytochromes P450 in cynomolgus monkeys mutagenically activate 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) but not 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx). PMID: 7614688 |
Ref: Urinary 6 beta-hydroxycortisol excretion in Hong Kong Chinese patients with hepatocellular carcinoma and other chronic liver diseases. PMID: 8608525 |
Ref: Metabolism of food-derived heterocyclic amines in nonhuman primates. PMID: 9202757 Ref: Aflatoxin B1-induced DNA adduct formation and p53 mutations in CYP450-expressing human liver cell lines. PMID: 9230270 |
Ref: Decrease in hepatic cytochrome P450 after interleukin-2 immunotherapy. PMID: 10086330 Ref: Identification and characterization of genes associated with human hepatocellular carcinogenesis. PMID: 10519413 |
Ref: Effect of the adrenal 11-beta-hydroxylase inhibitor metyrapone on human hepatic cytochrome P-450 expression: induction of cytochrome P-450 3A4. PMID: 10611146 Ref: Environmental and genetic determinants of aflatoxin-albumin adducts in the Gambia. PMID: 10728587 Ref: DX-8951f: summary of phase I clinical trials. PMID: 11193901 Ref: Expression of cytochrome P450 1A1/2 and 3A4 in liver tissues of hepatocellular carcinoma cases and controls from Taiwan and their relationship to hepatitis B virus and aflatoxin B1-and 4-aminobiphenyl-DNA adducts. PMID: 23885982 |
Ref: CYP3A4 inducible model for in vitro analysis of human drug metabolism using a bioartificial liver. PMID: 12601364 Ref: Differential drug-induced mRNA expression of human CYP3A4 compared to CYP3A5, CYP3A7 and CYP3A43. PMID: 12679136 Ref: Induction of CYP3A4 by 1alpha,25-dyhydroxyvitamin D3 in HepG2 cells. PMID: 12738030 Ref: Tamoxifen: is it safe? Comparison of activation and detoxication mechanisms in rodents and in humans. PMID: 12769667 |
Ref: Cytochrome P450 gene polymorphism and cancer. PMID: 15180491 Ref: Increased levels of aflatoxin-albumin adducts are associated with CYP3A5 polymorphisms in The Gambia, West Africa. PMID: 15454734 |
Ref: Formation and antitumor activity of PNU-159682, a major metabolite of nemorubicin in human liver microsomes. PMID: 15746066 Ref: Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents. PMID: 16144941 Ref: [Network for the collection and distribution of Japanese liver tissues resected surgically for drug development and research use]. PMID: 16541756 |
Ref: Increased CYP3A4 copy number in TONG/HCC cells but not in DNA from other humans. PMID: 16708050 Ref: Synthesis and characterization of a novel liver-targeted prodrug of cytosine-1-beta-D-arabinofuranoside monophosphate for the treatment of hepatocellular carcinoma. PMID: 17181153 |
Ref: Genetic variability in CYP3A4 and CYP3A5 in primary liver, gastric and colorectal cancer patients. PMID: 17605821 |
Ref: Chemosensitivity determinants of irinotecan hydrochloride in hepatocellular carcinoma cell lines. PMID: 18248513 Ref: Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells. PMID: 18784074 |
Ref: The effects of splicing variant of PXR PAR-2 on CYP3A4 and MDR1 mRNA expressions. PMID: 19232333 Ref: Expression of xenobiotic and steroid hormone metabolizing enzymes in hepatocellular tumors of the non-cirrhotic liver. PMID: 19596526 |
Ref: Human liver progenitor cell lines are readily established from non-tumorous tissue adjacent to hepatocellular carcinoma. PMID: 19874130 Ref: Protein phosphatase 2Cbetal regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells. PMID: 20538721 Ref: The role of selected cytochrome P450 enzymes on the bioactivation of aflatoxin B1 by duck liver microsomes. PMID: 20706884 Ref: The Chinese herbal medicine Sophora flavescens activates pregnane X receptor. PMID: 20736322 |
Ref: Whole-cell biotransformation assay for investigation of the human drug metabolizing enzyme CYP3A7. PMID: 20637317 Ref: Pharmacokinetic interaction involving sorafenib and the calcium-channel blocker felodipine in a patient with hepatocellular carcinoma. PMID: 20706860 Ref: Population pharmacokinetic analysis of sorafenib in patients with solid tumours. PMID: 21392074 Ref: Extrahepatic cancer suppresses nuclear receptor-regulated drug metabolism. PMID: 21498392 Ref: Overexpression of CYP3A4, but not of CYP2D6, promotes hypoxic response and cell growth of Hep3B cells. PMID: 21566342 Ref: [Expression systems of cytochrome P450 proteins in studies of drug metabolism in vitro]. PMID: 21734321 Ref: Construction and characterization of hepatocyte nuclear factor HNF4alpha1 over-expressing cell line derived from human hepatoma HepG2 cells. PMID: 21871880 Ref: Expression of albumin and cytochrome P450 enzymes in HepG2 cells cultured with a nanotechnology-based culture plate with microfabricated scaffold. PMID: 22008537 |
Ref: A simple and economical route to generate functional hepatocyte-like cells from hESCs and their application in evaluating alcohol induced liver damage. PMID: 21956183 Ref: Increased expression of drug-metabolizing enzymes in human hepatocarcinoma FLC-4 cells cultured on micro-space cell culture plates. PMID: 22447115 Ref: Dietary modulation of the biotransformation and genotoxicity of aflatoxin B(1). PMID: 22640941 Ref: Astemizole synergizes calcitriol antiproliferative activity by inhibiting CYP24A1 and upregulating VDR: a novel approach for breast cancer therapy. PMID: 22984610 Ref: STAT3 & Cytochrome P450 2C9: a novel signaling pathway in liver cancer stem cells. PMID: 23089473 |
Ref: Phase I and pharmacokinetic study of IV vinflunine in cancer patients with liver dysfunction. PMID: 22996801 Ref: Evaluation of Ginkgo biloba extract as an activator of human glucocorticoid receptor. PMID: 23220176 Ref: Cytotoxic effects of benzbromarone and its 1'-hydroxy metabolite in human hepatocarcinoma FLC4 cells cultured on micro-space cell culture plates. PMID: 23229783 Ref: Pharmacokinetic interaction between sorafenib and prednisolone in a patient with hepatocellular carcinoma. PMID: 23673446 Ref: Pungent ginger components modulates human cytochrome P450 enzymes in vitro. PMID: 23770984 Ref: Severe hypoglycemia due to possible interaction between glibenclamide and sorafenib in a patient with hepatocellular carcinoma. PMID: 23845193 Ref: Hepatitis B virus X protein co-activates pregnane X receptor to induce the cytochrome P450 3A4 enzyme, a potential implication in hepatocarcinogenesis. PMID: 23891548 Ref: Pharmacokinetic evaluation of the anticancer prodrug simmitecan in different experimental animals. PMID: 24056706 |
Ref: Marsdenia tenacissima extract inhibits gefitinib metabolism in vitro by interfering with human hepatic CYP3A4 and CYP2D6 enzymes. PMID: 24157377 Ref: In vitro inhibition of human liver cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzymes by rose bengal: system-dependent effects on inhibitory potential. PMID: 24405273 Ref: Sorafenib metabolism is significantly altered in the liver tumor tissue of hepatocellular carcinoma patient. PMID: 24797816 Ref: Short-term effects of oral administration of Pistacia lentiscus oil on tissue-specific toxicity and drug metabolizing enzymes in mice. PMID: 24853661 Ref: CYP3A4-dependent cellular response does not relate to CYP3A4-catalysed metabolites of C-1748 and C-1305 acridine antitumor agents in HepG2 cells. PMID: 24890801 Ref: Expression of P450 and nuclear receptors in normal and end-stage Chinese livers. PMID: 25024626 Ref: Dual-color fluorescence imaging to monitor CYP3A4 and CYP3A7 expression in human hepatic carcinoma HepG2 and HepaRG cells. PMID: 25101946 |
Ref: Significantly decreased and more variable expression of major CYPs and UGTs in liver microsomes prepared from HBV-positive human hepatocellular carcinoma and matched pericarcinomatous tissues determined using an isotope label-free UPLC-MS/MS method. PMID: 25288013 Ref: Effects of cytokines on CYP3A4 expression and reversal of the effects by anti-cytokine agents in the three-dimensionally cultured human hepatoma cell line FLC-4. PMID: 25760537 Ref: Effects of Sorafenib Dose on Acquired Reversible Resistance and Toxicity in Hepatocellular Carcinoma. PMID: 25908587 Ref: Drug-drug interation prediction between ketoconazole and anti-liver cancer drug Gomisin G. PMID: 26124807 |
Ref: Significant change of cytochrome P450s activities in patients with hepatocellular carcinoma. PMID: 27203676 Ref: Long-term exposure to abnormal glucose levels alters drug metabolism pathways and insulin sensitivity in primary human hepatocytes. PMID: 27312339 Ref: Immunohistochemical markers of CYP3A4 and CYP3A7: a new tool towards personalized pharmacotherapy of hepatocellular carcinoma. PMID: 27349315 Ref: Modulatory effects of rutin on the expression of cytochrome P450s and antioxidant enzymes in human hepatoma cells. PMID: 27749250 |
Ref: Cytotoxicity and cytochrome P450 inhibitory activities of Clinacanthus nutans. PMID: 28253196 Ref: Cis-Nerolidol Induces Endoplasmic Reticulum Stress and Cell Death in Human Hepatocellular Carcinoma Cells through Extensive CYP2C19 and CYP1A2 Oxidation. PMID: 28256105 Ref: Comprehensive assessment of Cucurbitacin E related hepatotoxicity and drug-drug interactions involving CYP3A and P-glycoprotein. PMID: 28257659 Ref: Altered cellular metabolism of HepG2 cells caused by microcystin-LR. PMID: 28336091 Ref: A Phase Ib Study of Sorafenib (BAY 43-9006) in Patients with Kaposi Sarcoma. PMID: 28341759 Ref: Proliferation of sphere-forming hepatocellular carcinoma cells is suppressed in a medium without glucose and arginine, but with galactose and ornithine. PMID: 28454244 Ref: Oxidative stress mediates an increased formation of vascular endothelial growth factor in human hepatocarcinoma cells exposed to erlotinib. PMID: 28915658 Ref: CYP3A4 Gene Is a Novel Biomarker for Predicting a Poor Prognosis in Hepatocellular Carcinoma. PMID: 29109094 |
Ref: Pazopanib-related tumor lysis syndrome in metastatic clear cell renal cell carcinoma: a case report. PMID: 29464464 Ref: Novel hydrazide-hydrazone and amide substituted coumarin derivatives: Synthesis, cytotoxicity screening, microarray, radiolabeling and in vivo pharmacokinetic studies. PMID: 29665526 Ref: The down-regulation of the CYP2C19 gene is associated with aggressive tumor potential and the poorer recurrence-free survival of hepatocellular carcinoma. PMID: 29774122 Ref: The prognostic value of differentially expressed CYP3A subfamily members for hepatocellular carcinoma. PMID: 29983591 Ref: Genistein affects expression of cytochrome P450 (CYP450) genes in hepatocellular carcinoma (HEPG2/C3A) cell line. PMID: 29984664 Ref: Downregulation of CYP2A6 and CYP2C8 in Tumor Tissues Is Linked to Worse Overall Survival and Recurrence-Free Survival from Hepatocellular Carcinoma. PMID: 30148168 Ref: Specific CYP450 Genotypes in the Chinese Population Affect Sorafenib Toxicity in HBV/HCV-associated Hepatocellular Carcinoma Patients. PMID: 30231963 Ref: LINE-1 ORF-1p enhances the transcription factor activity of pregnenolone X receptor and promotes sorafenib resistance in hepatocellular carcinoma cells. PMID: 30349375 |