Primary Site >> Liver Cancer

Gene >> CYP1A1

Journal: J Steroid Biochem. 1988 Dec;31(6):971-8.
Title: Effect of pretreatment of male Syrian golden hamsters with 7,8-benzoflavone and with diethylstilbestrol on P-450 isoenzyme activities and on microsomal diethylstilbestrol metabolism.
Author: Blaich, G|Metzler, M
PMID: 3199832
Journal: DNA. 1989 Sep;8(7):527-34.
Title: Transcriptional start site in the mouse Cyp1a1 (cytochrome P1450) gene.
Author: Jones, J E|Nebert, D W
PMID: 2766934
Journal: Biochem Int. 1989 Aug;19(2):413-20.
Title: Suppression of aryl hydrocarbon hydroxylase activity in human primary lung carcinoma x mouse hepatoma somatic cell hybrids.
Author: Manjunath, G S|Dufresne, M J
PMID: 2818604
Journal: Carcinogenesis. 1990 Nov;11(11):1979-84.
Title: Role of the maternal environment in determining susceptibility to transplacentally induced chemical carcinogenesis in mouse fetuses.
Author: Miller, M S|Jones, A B|Chauhan, D P|Anderson, L M
PMID: 1699680
Journal: J Steroid Biochem. 1990 Feb;35(2):201-4.
Title: Effects of various inducers on diethylstilbestrol metabolism, drug-metabolizing enzyme activities and the aromatic hydrocarbon (Ah) receptor in male Syrian golden hamster liver.
Author: Blaich, G|Gottlicher, M|Cikryt, P|Metzler, M
PMID: 2155352
Journal: DNA Cell Biol. 1990 Jul-Aug;9(6):425-36.
Title: Stable expression of mouse Cyp1a1 and human CYP1A2 cDNAs transfected into mouse hepatoma cells lacking detectable P450 enzyme activity.
Author: Puga, A|Raychaudhuri, B|Salata, K|Zhang, Y H|Nebert, D W
PMID: 2206399
Journal: Toxicology. 1990 Apr 17;61(2):147-59.
Title: Differential effects of 12-O-tetradecanoylphorbol 13-acetate on cytochrome P-450-dependent monooxygenase activities in rat hepatoma cells: induction of P-450I and suppression of P-450II.
Author: Roesch, S F|Wiebel, F J
PMID: 2321243
Journal: Hepatology. 1991 Nov;14(5):848-56.
Title: Localization of CYP1A1 and CYP1A2 messenger RNA in normal human liver and in hepatocellular carcinoma by in situ hybridization.
Author: McKinnon, R A|Hall, P D|Quattrochi, L C|Tukey, R H|McManus, M E
PMID: 1657755
Journal: Int J Radiat Oncol Biol Phys. 1994 May 15;29(2):277-83.
Title: Expression of xenobiotic-metabolizing enzymes by primary and secondary hepatic tumors in man.
Author: Philip, P A|Kaklamanis, L|Ryley, N|Stratford, I|Wolf, R|Harris, A|Carmichael, J
PMID: 8195019
Journal: Carcinogenesis. 1995 Nov;16(11):2807-11.
Title: Persistence of TCDD-induced hepatic cell proliferation and growth of enzyme altered foci after chronic exposure followed by cessation of treatment in DEN initiated female rats.
Author: Tritscher, A M|Clark, G C|Sewall, C|Sills, R C|Maronpot, R|Lucier, G W
PMID: 7586202
Journal: Carcinogenesis. 1995 Jul;16(7):1549-55.
Title: Cytochromes P450 in cynomolgus monkeys mutagenically activate 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) but not 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).
Author: Sadrieh, N|Snyderwine, E G
PMID: 7614688
Journal: FEBS Lett. 1995 May 29;365(2-3):101-7.
Title: Effect of a negative regulatory element (NRE) on the human CYP1A1 gene expression in breast carcinoma MCF-7 and hepatoma HepG2 cells.
Author: Jorgensen, E C|Autrup, H
PMID: 7781760
Journal: J Environ Pathol Toxicol Oncol. 1995;14(2):83-99.
Title: Zonal differences in DNA synthesis activity and cytochrome P450 gene expression in livers of male F344 rats treated with five nongenotoxic carcinogens.
Author: Chen, Z Y|White, C C|He, C Y|Liu, Y F|Eaton, D L
PMID: 9372837
Journal: Toxicol Appl Pharmacol. 1996 Jan;136(1):79-86.
Title: Modulation by iron of hepatic microsomal and nuclear cytochrome P450, and cytosolic glutathione S-transferase and peroxidase in C57BL/10ScSn mice induced with polychlorinated biphenyls (Aroclor 1254).
Author: Madra, S|Mann, F|Francis, J E|Manson, M M|Smith, A G
PMID: 8560483
Journal: Carcinogenesis. 1996 Jul;17(7):1519-26.
Title: Mouse lung tumors exhibit specific Ki-ras mutations following transplacental exposure to 3-methylcholanthrene.
Author: Wessner, L L|Fan, M|Schaeffer, D O|McEntee, M F|Miller, M S
PMID: 8706258
Journal: Eisei Shikenjo Hokoku. 1996;(114):21-6.
Title: [Intensity of liver tumor promotion effects in rats given repeated oral administrations of benzimidazole compounds].
Author: Onodera, H|Mitsumori, K|Uneyama, C|Yasuhara, K|Takegawa, K|Takahashi, M
PMID: 9037860
Journal: Environ Health Perspect. 1997 Jun;105 Suppl 4:749-54.
Title: Interaction between dose and susceptibility to environmental cancer: a short review.
Author: Hietanen, E|Husgafvel-Pursiainen, K|Vainio, H
PMID: 9255556
Journal: Arch Biochem Biophys. 1997 Dec 1;348(1):174-82.
Title: Studies on the relationship between estrogen receptor content, glutathione S-transferase pi expression, and induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and drug resistance in human breast cancer cells.
Author: Hoivik, D|Wilson, C|Wang, W|Willett, K|Barhoumi, R|Burghardt, R|Safe, S
PMID: 9390189
Journal: Environ Health Perspect. 1998 Feb;106 Suppl 1:349-55.
Title: The use of biochemical and molecular parameters to estimate dose-response relationships at low levels of exposure.
Author: Andersen, M E|Barton, H A
PMID: 9539029
Journal: Biochem Pharmacol. 1998 Jun 1;55(11):1791-6.
Title: Cytokine-mediated down-regulation of CYP1A1 in Hepa1 cells.
Author: Paton, T E|Renton, K W
PMID: 9714297
Journal: Biochem Pharmacol. 1998 Sep 1;56(5):599-612.
Title: Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene.
Author: Li, W|Harper, P A|Tang, B K|Okey, A B
PMID: 9783729
Journal: Cancer Res. 1999 Feb 1;59(3):607-14.
Title: Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase.
Author: Burczynski, M E|Lin, H K|Penning, T M
PMID: 9973208
Journal: Br J Cancer. 1999 May;80(3-4):598-603.
Title: Cytochrome P450 1A1 genetic polymorphisms and risk of hepatocellular carcinoma among chronic hepatitis B carriers.
Author: Yu, M W|Chiu, Y H|Yang, S Y|Santella, R M|Chern, H D|Liaw, Y F|Chen, C J
PMID: 10408872
Journal: Mol Pharmacol. 1999 Oct;56(4):760-7.
Title: Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol.
Author: Ciolino, H P|Yeh, G C
PMID: 10496959
Journal: Drug Metab Dispos. 2000 Jan;28(1):96-101.
Title: Effect of the adrenal 11-beta-hydroxylase inhibitor metyrapone on human hepatic cytochrome P-450 expression: induction of cytochrome P-450 3A4.
Author: Harvey, J L|Paine, A J|Maurel, P|Wright, M C
PMID: 10611146
Journal: Cancer Res. 2000 Feb 15;60(4):908-15.
Title: Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor.
Author: Burczynski, M E|Penning, T M
PMID: 10706104
Journal: Mutagenesis. 2000 Sep;15(5):379-83.
Title: Mutation frequency in the lacI gene of liver DNA from lambda/lacI transgenic mice following the interaction of PCBs with iron causing hepatic cancer and porphyria.
Author: Davies, R|Clothier, B|Smith, A G
PMID: 10970442
Journal: Toxicol Sci. 2000 Oct;57(2):217-28.
Title: Influence of beta-naphthoflavone on 7,12-dimethylbenz(a)anthracene metabolism, DNA adduction, and tumorigenicity in rainbow trout.
Author: Weimer, T L|Reddy, A P|Harttig, U|Alexander, D|Stamm, S C|Miller, M R|Baird, W|Hendricks, J|Bailey, G
PMID: 11006352
Journal: Toxicol Lett. 2000 Sep 30;117(1-2):69-77.
Title: Induction of cytochrome P450 1A1 in human hepatoma HepG2 cells by 6-nitrochrysene.
Author: Chen, R M|Chou, M W|Ueng, T H
PMID: 11033235
Journal: Chem Biol Interact. 2000 Nov 1;128(3):211-29.
Title: Comparative studies on the effects of green tea extracts and individual tea catechins on human CYP1A gene expression.
Author: Williams, S N|Shih, H|Guenette, D K|Brackney, W|Denison, M S|Pickwell, G V|Quattrochi, L C
PMID: 11064004
Journal: Biomarkers. 2000;5(4):295-306.
Title: Expression of cytochrome P450 1A1/2 and 3A4 in liver tissues of hepatocellular carcinoma cases and controls from Taiwan and their relationship to hepatitis B virus and aflatoxin B1-and 4-aminobiphenyl-DNA adducts.
Author: Zhang, Y J|Chen, S|Tsai, W Y|Ahsan, H|Lunn, R M|Wang, L|Chen, C J|Santella, R M
PMID: 23885982
Journal: Am J Respir Cell Mol Biol. 2001 Mar;24(3):339-44.
Title: Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and delta (9)-tetrahydrocannabinol.
Author: Roth, M D|Marques-Magallanes, J A|Yuan, M|Sun, W|Tashkin, D P|Hankinson, O
PMID: 11245634
Journal: Cancer Res. 2001 May 15;61(10):3942-8.
Title: Differential regulation of cytochrome P450 1A1 and 1B1 by a combination of dioxin and pesticides in the breast tumor cell line MCF-7.
Author: Coumoul, X|Diry, M|Robillot, C|Barouki, R
PMID: 11358810
Journal: Int J Cancer. 2002 May 1;99(1):14-21.
Title: Polycyclic aromatic hydrocarbon-DNA adducts in liver tissues of hepatocellular carcinoma patients and controls.
Author: Chen, Shu-Yuan|Wang, Li-Yu|Lunn, Ruth M|Tsai, Wei-Yann|Lee, Po-Huang|Lee, Chue-Shue|Ahsan, Habibul|Zhang, Yu-Jing|Chen, Chien-Jen|Santella, Regina M
PMID: 11948486
Journal: Arch Toxicol. 2002 Jun;76(5-6):287-98.
Title: Induction of CYP1A1, CYP1A2, and CYP1B1 mRNAs by nitropolycyclic aromatic hydrocarbons in various human tissue-derived cells: chemical-, cytochrome P450 isoform-, and cell-specific differences.
Author: Iwanari, Masashi|Nakajima, Miki|Kizu, Ryoichi|Hayakawa, Kazuichi|Yokoi, Tsuyoshi
PMID: 12107646
Journal: Biochem Biophys Res Commun. 2002 Aug 9;296(1):172-7.
Title: Characterization of human CYP1A1/1A2 induction by DNA microarray and alpha-naphthoflavone.
Author: Ishida, Seiichi|Jinno, Hideto|Tanaka-Kagawa, Toshiko|Ando, Masanori|Ohno, Yasuo|Ozawa, Shogo|Sawada, Jun ichi
PMID: 12147246
Journal: Int J Cancer. 2003 Apr 10;104(3):310-7.
Title: CYP enzyme polymorphisms and susceptibility to HCV-related chronic liver disease and liver cancer.
Author: Silvestri, Laura|Sonzogni, Laura|De Silvestri, Annalisa|Gritti, Chiara|Foti, Luciana|Zavaglia, Claudio|Leveri, Michela|Cividini, Agostino|Mondelli, Mario U|Civardi, Emilio|Silini, Enrico M
PMID: 12569554
Journal: Biomed Sci Instrum. 2003;39:389-96.
Title: CYP1a1, HSP70, P53, and c-fos expression in human liver carcinoma cells (HepG2) exposed to pentachlorophenol.
Author: Dorsey, Waneene C|Tchounwou, Paul B
PMID: 12724925
Journal: Mol Pharmacol. 2003 Jun;63(6):1373-81.
Title: Aryl hydrocarbon receptor gene silencing with small inhibitory RNA differentially modulates Ah-responsiveness in MCF-7 and HepG2 cancer cells.
Author: Abdelrahim, Maen|Smith, Roger 3rd|Safe, Stephen
PMID: 12761348
Journal: J Toxicol Environ Health A. 2003 Jun 27;66(12):1175-88.
Title: Effect of frying-meat emission particulate on 17beta-estradiol 2- and 4-hydroxylation in human lung adenocarcinoma CL5 cells.
Author: Wang, Hui-Wu|Ueng, Tzuu-Huei|Chen, Ta-Liang|Yang, Pan-Chyr
PMID: 12791542
Journal: Environ Health Perspect. 2003 Dec;111(16):1877-82.
Title: Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context.
Author: Zhang, Shu|Qin, Chunhua|Safe, Stephen H
PMID: 14644660
Journal: Cancer Res. 2004 Jan 1;64(1):429-34.
Title: The drug salicylamide is an antagonist of the aryl hydrocarbon receptor that inhibits signal transduction induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Author: MacDonald, Christopher J|Ciolino, Henry P|Yeh, Grace Chao
PMID: 14729655
Journal: Mol Cell Biochem. 2004 Jan;255(1-2):161-70.
Title: Lead-induced cytotoxicity and transcriptional activation of stress genes in human liver carcinoma (HepG2) cells.
Author: Tchounwou, Paul B|Yedjou, Clement G|Foxx, Dominique N|Ishaque, Ali B|Shen, Elaine
PMID: 14971657
Journal: Toxicology. 2004 Jul 1;199(2-3):231-40.
Title: Modulation of cytochrome P450 1A1 by food-derived heterocyclic aromatic amines.
Author: Hummerich, Jorg|Zohm, Christoph|Pfau, Wolfgang
PMID: 15147796
Journal: Curr Drug Metab. 2004 Jun;5(3):211-24.
Title: Cytochrome P450 gene polymorphism and cancer.
Author: Agundez, Jose A G
PMID: 15180491
Journal: Cancer Sci. 2004 Jun;95(6):520-9.
Title: Cytochrome p450 gene expression levels in peripheral blood mononuclear cells in comparison with the liver.
Author: Furukawa, Motonobu|Nishimura, Masuhiro|Ogino, Daisuke|Chiba, Ryoji|Ikai, Iwao|Ueda, Nobuhiko|Naito, Shinsaku|Kuribayashi, Shunji|Moustafa, Mohsen A|Uchida, Takafumi|Sawada, Hideki|Kamataki, Tetsuya|Funae, Yoshihiko|Fukumoto, Manabu
PMID: 15182434
Journal: In Vitro Cell Dev Biol Anim. 2004 Mar-Apr;40(3-4):118-28.
Title: Development of rainbow trout hepatoma cell lines: effect of pro-IGF-I Ea4-peptide on morphological changes and anchorage-independent growth.
Author: Chen, Maria J|Chiou, P Peter|Yang, Bih-Ying|Lo, Hung Chieh|Son, Jin-Ki|Hendricks, Jerry|Bailey, George|Chen, Thomas T
PMID: 15311963
Journal: Cancer Lett. 2004 Aug 30;212(2):195-201.
Title: Polymorphisms of estrogen-metabolizing genes and risk of hepatocellular carcinoma in Taiwan females.
Author: Yin, Pen-Hui|Lee, Hsin-Chen|Chau, Gar-Yang|Liu, Tsung-Yun|Liu, Hsiu-Chih|Lui, Wing-Yiu|Chi, Chin-Wen
PMID: 15341023
Journal: Toxicol Sci. 2004 Dec;82(2):488-96.
Title: Effects of polybrominated diphenyl ethers on basal and TCDD-induced ethoxyresorufin activity and cytochrome P450-1A1 expression in MCF-7, HepG2, and H4IIE cells.
Author: Peters, A K|van Londen, K|Bergman, A|Bohonowych, J|Denison, M S|van den Berg, M|Sanderson, J T
PMID: 15456928
Journal: Int J Environ Res Public Health. 2004 Mar;1(1):12-20.
Title: Cytotoxicity and transcriptional activation of stress genes in human liver carcinoma (HepG2) cells exposed to iprodione.
Author: Washington, Teresa|Tchounwou, Paul B
PMID: 16696176
Journal: J Pharm Sci. 2005 Mar;94(3):493-506.
Title: Down-regulation of aryl hydrocarbon receptor-regulated genes by tumor necrosis factor-alpha and lipopolysaccharide in murine hepatoma Hepa 1c1c7 cells.
Author: Gharavi, Negar|El-Kadi, Ayman O S
PMID: 15627257
Journal: Carcinogenesis. 2005 Apr;26(4):803-9.
Title: 5,7-Dimethoxyflavone downregulates CYP1A1 expression and benzo[a]pyrene-induced DNA binding in Hep G2 cells.
Author: Wen, Xia|Walle, U Kristina|Walle, Thomas
PMID: 15661813
Journal: Cancer Lett. 2005 Nov 18;229(2):181-91.
Title: Tumor suppressive effects of tocotrienol in vivo and in vitro.
Author: Wada, Sayori|Satomi, Yoshiko|Murakoshi, Michiaki|Noguchi, Noriko|Yoshikawa, Toshikazu|Nishino, Hoyoku
PMID: 16098658
Journal: Eur J Cell Biol. 2006 May;85(5):387-97.
Title: Effect of some carcinogenic and non-carcinogenic polycyclic aromatic hydrocarbons on gap junction intercellular communication in hepatoma cell cultures.
Author: Sharovskaya, Julia|Kobliakova, Ioulia|Solomatina, Natalya|Kobliakov, Valery
PMID: 16412531
Journal: Carcinogenesis. 2006 Aug;27(8):1586-92.
Title: Sulindac regulates the aryl hydrocarbon receptor-mediated expression of Phase 1 metabolic enzymes in vivo and in vitro.
Author: Ciolino, Henry P|MacDonald, Christopher J|Memon, Omar S|Bass, Sara E|Yeh, Grace Chao
PMID: 16531450
Journal: Mol Nutr Food Res. 2006 Apr;50(4-5):378-84.
Title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin induced cytochrome P450s alter the formation of reactive oxygen species in liver cells.
Author: Knerr, Stefanie|Schaefer, Johanna|Both, Saskia|Mally, Angela|Dekant, Wolfgang|Schrenk, Dieter
PMID: 16534750
Journal: Drug Metab Dispos. 2006 Jul;34(7):1096-101.
Title: Regulation of CYP1A1 gene expression by the antioxidant tert-butylhydroquinone.
Author: Schreiber, Thomas D|Kohle, Christoph|Buckler, Felicitas|Schmohl, Stefan|Braeuning, Albert|Schmiechen, Alexander|Schwarz, Michael|Munzel, Peter A
PMID: 16581943
Journal: Toxicol Lett. 2006 Aug 20;165(2):174-81.
Title: Quantitative relationship of dioxin-responsive gene expression to dioxin response element in Hep3B and HepG2 human hepatocarcinoma cell lines.
Author: Kim, Won Kon|In, Yu-Jung|Kim, Jin-Ho|Cho, Hyun-Ju|Kim, Ji-Hye|Kang, Sunghyun|Lee, Chul Young|Lee, Sang Chul
PMID: 16697128
Journal: Mol Pharmacol. 2006 Sep;70(3):1062-70.
Title: Regulation of the CYP1A1 gene by 2,3,7,8-tetrachlorodibenzo-p-dioxin but not by beta-naphthoflavone or 3-methylcholanthrene is altered in hepatitis C virus replicon-expressing cells.
Author: Anderson, Garret R|Hasan, Aliya|Yin, Hao|Qadri, Ishtiaq|Quattrochi, Linda C
PMID: 16788090
Journal: Mol Pharmacol. 2006 Nov;70(5):1481-7.
Title: Calpain mediates the dioxin-induced activation and down-regulation of the aryl hydrocarbon receptor.
Author: Dale, Yolanda R|Eltom, Sakina E
PMID: 16891617
Journal: Natl Toxicol Program Tech Rep Ser. 2006 Aug;(530):1-258.
Title: Toxicology and carcinogenesis studies of a binary mixture of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) (Cas No. 57465-28-8) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) (CAS No. 35065-27-1) in female Harlan Sprague-Dawley rats (gavage studies).
Author:
PMID: 17160104
Journal: Natl Toxicol Program Tech Rep Ser. 2006 Nov;(531):1-218.
Title: Toxicology and carcinogenesis studies of a binary mixture of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) (Cas No. 57465-28-8) and 2,3',4,4',5-pentachlorobiphenyl (PCB 118) (Cas No. 31508-00-6) in female Harlan Sprague-Dawley rats (gavage studies).
Author:
PMID: 17342196
Journal: Int J Gastrointest Cancer. 2006;37(2-3):79-83.
Title: Identification of CYP2C9*2 allele in HepG2 cell line.
Author: Chen, Jiezhong|Raymond, Kenneth
PMID: 17827526
Journal: Neurotoxicology. 2007 May;28(3):594-612.
Title: The aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl induces distinct patterns of gene expression between hepatoma and glioma cells: chromatin remodeling as a mechanism for selective effects.
Author: Maier, Mark S V|Legare, Marie E|Hanneman, William H
PMID: 17316808
Journal: Aquat Toxicol. 2007 Oct 15;84(3):301-9.
Title: 17alpha-Ethinylestradiol decreases expression of multiple hepatic nucleotide excision repair genes in zebrafish (Danio rerio).
Author: Notch, Emily G|Miniutti, Danielle M|Mayer, Gregory D
PMID: 17662478
Journal: Food Chem Toxicol. 2008 Apr;46(4):1230-8.
Title: Effects of coffee and its chemopreventive components kahweol and cafestol on cytochrome P450 and sulfotransferase in rat liver.
Author: Huber, Wolfgang W|Rossmanith, Walter|Grusch, Michael|Haslinger, Elisabeth|Prustomersky, Sonja|Peter-Vorosmarty, Barbara|Parzefall, Wolfram|Scharf, Gerlinde|Schulte-Hermann, Rolf
PMID: 17983700
Journal: Arzneimittelforschung. 2008;58(5):225-41.
Title: Ciprofibrate, clofibric acid and respective glycinate derivatives. Effects of a four-week treatment on male lean and obese Zucker rats.
Author: Lupp, Amelie|Karge, Elke|Deufel, Thomas|Oelschlagers, Herbert|Fleck, Christian
PMID: 18589557
Journal: Free Radic Res. 2008 Oct;42(10):873-84.
Title: Black tea polyphenols modulate xenobiotic-metabolizing enzymes, oxidative stress and adduct formation in a rat hepatocarcinogenesis model.
Author: Murugan, Ramalingam Senthil|Uchida, Koji|Hara, Yukihiko|Nagini, Siddavaram
PMID: 18985486
Journal: Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3621-7.
Title: Lack of association between the functional polymorphisms in the estrogen-metabolizing genes and risk for hepatocellular carcinoma.
Author: Yuan, Xiaoyan|Zhou, Gangqiao|Zhai, Yun|Xie, Weimin|Cui, Ying|Cao, Jia|Zhi, Lianteng|Zhang, Hongxing|Yang, Hao|Zhang, Xiaoai|Qiu, Wei|Peng, Yong|Zhang, Xiumei|Yu, Ling|Xia, Xia|He, Fuchu
PMID: 19064581
Journal: Cell Mol Neurobiol. 2009 May;29(3):383-9.
Title: Gamma-ray up-regulated holocarboxylase synthetase gene.
Author: Ding, Kuke|Yang, Chunjie|Shen, Jingjing|Xu, Lili|Li, Yanling|Zhou, Pinkun|Zeng, Yanjun
PMID: 19048367
Journal: Eur J Cancer. 2009 May;45(7):1239-47.
Title: Common genetic variations of the cytochrome P450 1A1 gene and risk of hepatocellular carcinoma in a Chinese population.
Author: Li, Rui|Shugart, Yin Yao|Zhou, Weiping|An, Yu|Yang, Yuan|Zhou, Yun|Zhang, Beibei|Lu, Daru|Wang, Hongyang|Qian, Ji|Jin, Li
PMID: 19110417
Journal: Toxicol Sci. 2009 Jul;110(1):61-7.
Title: Resveratrol inhibits dioxin-induced expression of human CYP1A1 and CYP1B1 by inhibiting recruitment of the aryl hydrocarbon receptor complex and RNA polymerase II to the regulatory regions of the corresponding genes.
Author: Beedanagari, Sudheer R|Bebenek, Ilona|Bui, Peter|Hankinson, Oliver
PMID: 19376845
Journal: World J Gastroenterol. 2009 May 21;15(19):2345-50.
Title: Celecoxib enhances the detoxification of diethylnitrosamine in rat liver cancer.
Author: Salcido-Neyoy, Martha Estela|Sierra-Santoyo, Adolfo|Beltran-Ramirez, Olga|Macias-Perez, Jose Roberto|Villa-Trevino, Saul
PMID: 19452576
Journal: Crit Rev Toxicol. 2009;39(4):299-331.
Title: Weight of evidence evaluation of potential human cancer risks from exposure to polychlorinated biphenyls: an update based on studies published since 2003.
Author: Golden, Robert|Kimbrough, Renate
PMID: 19514916
Journal: Pathol Res Pract. 2009;205(10):716-25.
Title: Expression of xenobiotic and steroid hormone metabolizing enzymes in hepatocellular tumors of the non-cirrhotic liver.
Author: Haas, Susanne|Merkelbach-Bruse, Sabine|Justenhoven, Christina|Brauch, Hiltrud|Fischer, Hans-Peter
PMID: 19596526
Journal: Carcinogenesis. 2009 Oct;30(10):1729-34.
Title: Interaction between cytochrome P450 1A2 genetic polymorphism and cigarette smoking on the risk of hepatocellular carcinoma in a Japanese population.
Author: Imaizumi, Takeshi|Higaki, Yasuki|Hara, Megumi|Sakamoto, Tatsuhiko|Horita, Mikako|Mizuta, Toshihiko|Eguchi, Yuichiro|Yasutake, Tsutomu|Ozaki, Iwata|Yamamoto, Kyosuke|Onohara, Shingo|Kawazoe, Seiji|Shigematsu, Hirohisa|Koizumi, Shunzo|Kudo, Sho|Tanaka, Keit
PMID: 19643819
Journal: Environ Toxicol Pharmacol. 2009 Nov;28(3):370-8.
Title: The inducibility of human cytochrome P450 1A by environmental-relevant xenobiotics in the human hepatoma derived cell line HepG2.
Author: Rudzok, Susanne|Schmucking, Eike|Graebsch, Carolin|Herbarth, Olf|Bauer, Mario
PMID: 21784029
Journal: Biochem Biophys Res Commun. 2010 Feb 19;392(4):473-8.
Title: Emodin inhibits the growth of hepatoma cells: finding the common anti-cancer pathway using Huh7, Hep3B, and HepG2 cells.
Author: Hsu, Chin-Mu|Hsu, Yu-An|Tsai, Yuhsin|Shieh, Fa-Kuen|Huang, Su-Hua|Wan, Lei|Tsai, Fuu-Jen
PMID: 19895793
Journal: Planta Med. 2010 May;76(7):671-7.
Title: Peganum harmala L. is a candidate herbal plant for preventing dioxin mediated effects.
Author: El Gendy, Mohamed A M|Somayaji, Vishwa|El-Kadi, Ayman O S
PMID: 19941261
Journal: J Toxicol Sci. 2010 Feb;35(1):69-78.
Title: The threshold dose for liver tumor promoting effects of dicyclanil in ICR mice.
Author: Jin, Meilan|Dewa, Yasuaki|Kawai, Masaomi|Nishimura, Jihei|Saegusa, Yukie|Kemmochi, Sayaka|Harada, Tomoaki|Shibutani, Makoto|Mitsumori, Kunitoshi
PMID: 20118626
Journal: Avian Pathol. 2010 Aug;39(4):279-85.
Title: The role of selected cytochrome P450 enzymes on the bioactivation of aflatoxin B1 by duck liver microsomes.
Author: Diaz, Gonzalo J|Murcia, Hansen W|Cepeda, Sandra M|Boermans, Herman J
PMID: 20706884
Journal: Toxicology. 2010 Nov 9;277(1-3):59-65.
Title: Functional analysis of six human aryl hydrocarbon receptor variants in human breast cancer and mouse hepatoma cell lines.
Author: Celius, Trine|Matthews, Jason
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Journal: Toxicol Appl Pharmacol. 2010 Dec 15;249(3):224-30.
Title: Role of retinoic acid in the modulation of benzo(a)pyrene-DNA adducts in human hepatoma cells: implications for cancer prevention.
Author: Zhou, Guo-Dong|Richardson, Molly|Fazili, Inayat S|Wang, Jianbo|Donnelly, Kirby C|Wang, Fen|Amendt, Brad|Moorthy, Bhagavatula
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Journal: Natl Toxicol Program Tech Rep Ser. 2010 Nov;(559):1-174.
Title: Toxicology and carcinogenesis studies of 2,3',4,4',5-pentachlorobiphenyl (PCB 118) (CAS No. 31508-00-6) in female harlan Sprague-Dawley rats (gavage studies).
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Journal: J Ethnopharmacol. 2011 Jan 7;133(1):184-90.
Title: Camel urine inhibits the cytochrome P450 1a1 gene expression through an AhR-dependent mechanism in Hepa 1c1c7 cell line.
Author: Alhaider, Abdulqader A|El Gendy, Mohamed A M|Korashy, Hesham M|El-Kadi, Ayman O S
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Journal: Arch Toxicol. 2011 Sep;85(9):1159-66.
Title: Relationship between CYP1A induction by indole-3-carbinol or flutamide and liver tumor-promoting potential in rats.
Author: Shimamoto, Keisuke|Dewa, Yasuaki|Kemmochi, Sayaka|Taniai, Eriko|Hayashi, Hitomi|Imaoka, Masako|Shibutani, Makoto|Mitsumori, Kunitoshi
PMID: 21203749
Journal: Toxicology. 2011 May 10;283(2-3):109-17.
Title: Indole-3-carbinol enhances oxidative stress responses resulting in the induction of preneoplastic liver cell lesions in partially hepatectomized rats initiated with diethylnitrosamine.
Author: Shimamoto, Keisuke|Dewa, Yasuaki|Ishii, Yuji|Kemmochi, Sayaka|Taniai, Eriko|Hayashi, Hitomi|Imaoka, Masako|Morita, Reiko|Kuwata, Kazunori|Suzuki, Kazuhiko|Shibutani, Makoto|Mitsumori, Kunitoshi
PMID: 21396975
Journal: Arch Toxicol. 2011 Dec;85(12):1617-26.
Title: Genotoxic effects of the cyanobacterial hepatotoxin cylindrospermopsin in the HepG2 cell line.
Author: Straser, Alja|Filipic, Metka|Zegura, Bojana
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Journal: Eur J Pharmacol. 2011 Nov 1;669(1-3):45-50.
Title: Construction and characterization of hepatocyte nuclear factor HNF4alpha1 over-expressing cell line derived from human hepatoma HepG2 cells.
Author: Novotna, Aneta|Doricakova, Aneta|Vrzal, Radim|Pavek, Petr|Dvorak, Zdenek
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Journal: Arch Toxicol. 2012 Mar;86(3):497-507.
Title: Mechanistic study on liver tumor promoting effects of flutamide in rats.
Author: Tawfeeq, Mohammad Monir|Hayashi, Hitomi|Shimamoto, Keisuke|Suzuki, Kazuhiko|Shibutani, Makoto|Inokuma, Hisashi|Mitsumori, Kunitoshi
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Journal: Mol Biol Rep. 2012 Jun;39(6):6641-6.
Title: Interactions between CYP1A1 polymorphisms and cigarette smoking are associated with the risk of hepatocellular carcinoma: evidence from epidemiological studies.
Author: Yu, Lei|Sun, Lei|Jiang, Yang-Fang|Lu, Bao-Ling|Sun, De-Rong|Zhu, Li-Ying
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Journal: J Biomed Biotechnol. 2012;2012:782642.
Title: Camel milk modulates the expression of aryl hydrocarbon receptor-regulated genes, Cyp1a1, Nqo1, and Gsta1, in murine hepatoma Hepa 1c1c7 cells.
Author: Korashy, Hesham M|El Gendy, Mohamed A M|Alhaider, Abdulqader A|El-Kadi, Ayman O
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Journal: J Toxicol Sci. 2012;37(3):491-501.
Title: Liver tumor promoting effect of omeprazole in rats and its possible mechanism of action.
Author: Hayashi, Hitomi|Shimamoto, Keisuke|Taniai, Eriko|Ishii, Yuji|Morita, Reiko|Suzuki, Kazuhiko|Shibutani, Makoto|Mitsumori, Kunitoshi
PMID: 22687989
Journal: J Toxicol Sci. 2012;37(3):517-26.
Title: Threshold dose of liver tumor promoting effect of beta-naphthoflavone in rats.
Author: Hayashi, Hitomi|Taniai, Eriko|Morita, Reiko|Yafune, Atsunori|Suzuki, Kazuhiko|Shibutani, Makoto|Mitsumori, Kunitoshi
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Journal: Mol Biol Rep. 2012 Sep;39(9):8977-8.
Title: Methodological remarks concerning the recent meta-analysis on CYP1A1 polymorphisms-smoking interaction and hepatocellular carcinoma risk.
Author: Liu, Fei|Li, Bo|Wei, Yong-Gang|Wang, Wen-Tao
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Journal: Pharmacol Rep. 2012;64(4):927-39.
Title: Expression of genes involved in xenobiotic metabolism and transport in end-stage liver disease: up-regulation of ABCC4 and CYP1B1.
Author: Kurzawski, Mateusz|Dziedziejko, Violetta|Post, Mariola|Wojcicki, Maciej|Urasinska, Elzbieta|Mietkiewski, Janusz|Drozdzik, Marek
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Journal: Mol Biol Rep. 2013 May;40(5):3847-9.
Title: Are CYP1A1 polymorphisms associated with the risk of hepatocellular carcinoma?
Author: Wan, Tao
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Journal: Toxicol In Vitro. 2013 Sep;27(6):1809-19.
Title: Cylindrospermopsin induced transcriptional responses in human hepatoma HepG2 cells.
Author: Straser, Alja|Filipic, Metka|Zegura, Bojana
PMID: 23726867
Journal: J Toxicol Sci. 2013;38(5):679-88.
Title: Suppressive effect of liver tumor-promoting activities in rats subjected to combined administration of phenobarbital and piperonyl butoxide.
Author: Morita, Reiko|Yafune, Atsunori|Shiraki, Ayako|Itahashi, Megu|Akane, Hirotoshi|Nakane, Fumiyuki|Suzuki, Kazuhiko|Shibutani, Makoto|Mitsumori, Kunitoshi
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Journal: BMC Mol Biol. 2013 Dec 12;14:27.
Title: An aryl hydrocarbon receptor induces VEGF expression through ATF4 under glucose deprivation in HepG2.
Author: Terashima, Jun|Tachikawa, Chie|Kudo, Kenzo|Habano, Wataru|Ozawa, Shogo
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Journal: Tumour Biol. 2014 Apr;35(4):3363-76.
Title: Association between the CYP1A1 A2455G polymorphism and risk of cancer: evidence from 272 case-control studies.
Author: Qin, Jun|Zhang, Jin-Xia|Li, Xiao-Ping|Wu, Bu-Qiang|Chen, Guang-Bin|He, Xiao-Feng
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Journal: Gene. 2014 Jan 25;534(2):324-44.
Title: Association between the CYP1A1 T3801C polymorphism and risk of cancer: evidence from 268 case-control studies.
Author: He, Xiao-Feng|Wei, Wu|Liu, Zhi-Zhong|Shen, Xu-Liang|Yang, Xian-Bin|Wang, Su-Lan|Xie, Dao-Lin
PMID: 24498651
Journal: Cell Physiol Biochem. 2014;33(5):1400-10.
Title: Short-term effects of oral administration of Pistacia lentiscus oil on tissue-specific toxicity and drug metabolizing enzymes in mice.
Author: Attoub, Samir|Karam, Sherif M|Nemmar, Abderrahim|Arafat, Kholoud|John, Annie|Al-Dhaheri, Wafa|Al Sultan, Mahmood Ahmed|Raza, Haider
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Journal: Environ Toxicol Pharmacol. 2014 Nov;38(3):742-50.
Title: Altered gene expression in HepG2 cells exposed to a methanolic coal dust extract.
Author: Guerrero-Castilla, Angelica|Olivero-Verbel, Jesus
PMID: 25305735
Journal: Curr Drug Metab. 2014;15(8):829-40.
Title: Enzymes oxidizing the azo dye 1-phenylazo-2-naphthol (Sudan I) and their contribution to its genotoxicity and carcinogenicity.
Author: Stiborova, Marie|Schmeiser, Heinz H|Frei, Eva|Hodek, Petr|Martinek, Vaclav
PMID: 25658126
Journal: Hepatology. 2015 Feb;61(2):548-60.
Title: Lineage-dependent effects of aryl hydrocarbon receptor agonists contribute to liver tumorigenesis.
Author: Harrill, Joshua A|Parks, Bethany B|Wauthier, Eliane|Rowlands, J Craig|Reid, Lola M|Thomas, Russell S
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Journal: Mater Sci Eng C Mater Biol Appl. 2015 Jan;46:190-4.
Title: A novel effect of parylene-based surface coating on HepG2 cell function.
Author: Tozawa, Hideto|Maekawa, Toshiro|Kimura, Hiroshi|Fujii, Teruo
PMID: 25491976
Journal: Biomed Res Int. 2015;2015:179867.
Title: The effect of CYP, GST, and SULT polymorphisms and their interaction with smoking on the risk of hepatocellular carcinoma.
Author: Boccia, Stefania|Miele, Luca|Panic, Nikola|Turati, Federica|Arzani, Dario|Cefalo, Consuelo|Amore, Rosarita|Bulajic, Milutin|Pompili, Maurizio|Rapaccini, Gianlodovico|Gasbarrini, Antonio|La Vecchia, Carlo|Grieco, Antonio
PMID: 25654087
Journal: Genet Mol Res. 2015 Feb 6;14(1):1076-84.
Title: Association between the CYP1A1 polymorphisms and hepatocellular carcinoma: a meta-analysis.
Author: Yu, B W|Zhang, L Q|Teng, X L|Zhang, Y|Zou, L B|Ying, H Y
PMID: 25730047
Journal: J Nat Med. 2015 Jul;69(3):313-23.
Title: Chemopreventive and therapeutic potentials of thymoquinone in HepG2 cells: mechanistic perspectives.
Author: ElKhoely, Abeer|Hafez, Hafez F|Ashmawy, Abeer M|Badary, Osama|Abdelaziz, Ahmed|Mostafa, Adel|Shouman, Samia A
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Journal: Chem Res Toxicol. 2015 May 18;28(5):907-18.
Title: Omeprazole Inhibits Pancreatic Cancer Cell Invasion through a Nongenomic Aryl Hydrocarbon Receptor Pathway.
Author: Jin, Un-Ho|Kim, Sang-Bae|Safe, Stephen
PMID: 25826687
Journal: Toxicol Sci. 2015 Oct;147(2):549-61.
Title: Mechanistic Investigation of Toxaphene Induced Mouse Liver Tumors.
Author: Wang, Zemin|Neal, Barbara H|Lamb, James C|Klaunig, James E
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Journal: Toxicology. 2015 Oct 2;336:99-112.
Title: Screening a mouse liver gene expression compendium identifies modulators of the aryl hydrocarbon receptor (AhR).
Author: Oshida, Keiyu|Vasani, Naresh|Thomas, Russell S|Applegate, Dawn|Gonzalez, Frank J|Aleksunes, Lauren M|Klaassen, Curtis D|Corton, J Christopher
PMID: 26215100
Journal: Adv Pharmacol. 2015;74:85-111.
Title: Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases.
Author: Daly, Ann K
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Journal: Drug Metab Pharmacokinet. 2015 Dec;30(6):434-40.
Title: CYP1A1 and CYP1A2 expression levels are differentially regulated in three-dimensional spheroids of liver cancer cells compared to two-dimensional monolayer cultures.
Author: Terashima, Jun|Goto, Shinpei|Hattori, Hiroki|Hoshi, Sawaka|Ushirokawa, Midori|Kudo, Kenzo|Habano, Wataru|Ozawa, Shogo
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Journal: Springerplus. 2016 Apr 6;5:413.
Title: Root extract of water dropwort, Oenanthe javanica (Blume) DC, induces protein and gene expression of phase I carcinogen-metabolizing enzymes in HepG2 cells.
Author: Kim, Jae Kyeom|Shin, Eui-Cheol|Park, Gwi Gun|Kim, Youn-Jung|Shin, Dong-Hoon
PMID: 27069833
Journal: Biochem Genet. 2016 Oct;54(5):696-713.
Title: Genetic Polymorphisms of Cytochrome P4501A1 (CYP1A1) and Glutathione S-Transferase P1 (GSTP1) and Risk of Hepatocellular Carcinoma Among Chronic Hepatitis C Patients in Egypt.
Author: Abo-Hashem, Ekbal M|El-Emshaty, Wafaa M|Farag, Raghda El Sayed|Zakaria, Sahar|Abd El-Aziz, Mohammed|Ghonaim, Azza
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Journal: Regul Toxicol Pharmacol. 2016 Nov;81:421-429.
Title: Methyl isobutyl ketone-induced hepatocellular carcinogenesis in B6C3F1 mice: A constitutive androstane receptor (CAR)-mediated mode of action.
Author: Hughes, B J|Thomas, J|Lynch, A M|Borghoff, S J|Green, S|Mensing, T|Sarang, S S|LeBaron, M J
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Journal: Acta Pharm. 2016 Dec 1;66(4):491-502.
Title: Modulatory effects of rutin on the expression of cytochrome P450s and antioxidant enzymes in human hepatoma cells.
Author: Karakurt, Sedar
PMID: 27749250
Journal: Protein Pept Lett. 2017 May 10;24(5):406-412.
Title: Diosmetin Induces Cell Apoptosis by Regulating CYP1A1/CYP1A2 Due to p53 Activation in HepG2 Cells.
Author: Liu, Bin|Jia, Kaiqiao|Yang, Yu|Hao, Siyuan|Lu, Caijie|Xu, Fengming|Feng, Dehui|Zhu, Runzhi
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Journal: Food Chem Toxicol. 2017 May;103:122-132.
Title: Hydroxystilbenes and methoxystilbenes activate human aryl hydrocarbon receptor and induce CYP1A genes in human hepatoma cells and human hepatocytes.
Author: Pastorkova, Barbora|Vrzalova, Aneta|Bachleda, Petr|Dvorak, Zdenek
PMID: 28279696
Journal: Anticancer Res. 2017 Mar;37(3):1197-1204.
Title: Comparison of the Effects of Monastrol and Oxomonastrol on Human Hepatoma Cell Line HepG2/C3A.
Author: Marques, Lilian Areal|Semprebon, Simone Cristine|Sartori, Daniele|DE Fatima, Angelo|Ribeiro, Lucia Regina|Mantovani, Mario Sergio
PMID: 28314282
Journal: Can J Physiol Pharmacol. 2017 Jun;95(6):768-771.
Title: Downregulation of cytochrome P450 2C8 by 3-methylcholanthrene in human hepatocellular carcinoma cell lines.
Author: Utgikar, Rucha|Riddick, David S
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Journal: Toxicol Lett. 2017 Jun 5;275:77-82.
Title: Activated thyroid hormone receptor modulates dioxin-inducible aryl hydrocarbon receptor-mediated CYP1A1 induction in human hepatocytes but not in human hepatocarcinoma HepG2 cells.
Author: Vrzal, Radim|Vrzalova, Aneta|Grycova, Aneta|Dvorak, Zdenek
PMID: 28478156
Journal: Biochem J. 2017 Sep 28;474(20):3391-3402.
Title: Carbidopa is an activator of aryl hydrocarbon receptor with potential for cancer therapy.
Author: Ogura, Jiro|Miyauchi, Seiji|Shimono, Kazumi|Yang, Shengping|Gonchigar, Sathisha|Ganapathy, Vadivel|Bhutia, Yangzom D
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Journal: Environ Toxicol Pharmacol. 2018 Apr;59:199-207.
Title: Biotransformation and oxidative stress responses in rat hepatic cell-line (H4IIE) exposed to racemic ketoprofen (RS-KP) and its enantiomer, dexketoprofen (S(+)-KP).
Author: Mennillo, Elvira|Krokje, Ase|Pretti, Carlo|Meucci, Valentina|Arukwe, Augustine
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Journal: J Cancer. 2018 Apr 6;9(8):1506-1517.
Title: The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta-Analysis.
Author: Du, Le|Lei, Lei|Zhao, Xiaojuan|He, Hongjuan|Chen, Erfei|Dong, Jing|Zeng, Yuan|Yang, Jin
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Journal: Drug Metab Lett. 2018 Jul 9. pii: DML-EPUB-91604.
Title: Genistein affects expression of cytochrome P450 (CYP450) genes in hepatocellular carcinoma (HEPG2/C3A) cell line.
Author: Lepri, Sandra Regina|Sartori, Daniele|Semprebon, Simone Cristine|Baranoski, Adrivanio|Coatti, Giuliana Castello|Mantovani, Mario Sergio
PMID: 29984664