Primary Site >> Liver Cancer
Gene >> CYP1A1
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Ref: Effect of pretreatment of male Syrian golden hamsters with 7,8-benzoflavone and with diethylstilbestrol on P-450 isoenzyme activities and on microsomal diethylstilbestrol metabolism. PMID: 3199832 |
Ref: Transcriptional start site in the mouse Cyp1a1 (cytochrome P1450) gene. PMID: 2766934 Ref: Suppression of aryl hydrocarbon hydroxylase activity in human primary lung carcinoma x mouse hepatoma somatic cell hybrids. PMID: 2818604 |
Ref: Role of the maternal environment in determining susceptibility to transplacentally induced chemical carcinogenesis in mouse fetuses. PMID: 1699680 Ref: Effects of various inducers on diethylstilbestrol metabolism, drug-metabolizing enzyme activities and the aromatic hydrocarbon (Ah) receptor in male Syrian golden hamster liver. PMID: 2155352 Ref: Stable expression of mouse Cyp1a1 and human CYP1A2 cDNAs transfected into mouse hepatoma cells lacking detectable P450 enzyme activity. PMID: 2206399 Ref: Differential effects of 12-O-tetradecanoylphorbol 13-acetate on cytochrome P-450-dependent monooxygenase activities in rat hepatoma cells: induction of P-450I and suppression of P-450II. PMID: 2321243 |
Ref: Localization of CYP1A1 and CYP1A2 messenger RNA in normal human liver and in hepatocellular carcinoma by in situ hybridization. PMID: 1657755 |
Ref: Expression of xenobiotic-metabolizing enzymes by primary and secondary hepatic tumors in man. PMID: 8195019 |
Ref: Persistence of TCDD-induced hepatic cell proliferation and growth of enzyme altered foci after chronic exposure followed by cessation of treatment in DEN initiated female rats. PMID: 7586202 Ref: Cytochromes P450 in cynomolgus monkeys mutagenically activate 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) but not 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx). PMID: 7614688 Ref: Effect of a negative regulatory element (NRE) on the human CYP1A1 gene expression in breast carcinoma MCF-7 and hepatoma HepG2 cells. PMID: 7781760 Ref: Zonal differences in DNA synthesis activity and cytochrome P450 gene expression in livers of male F344 rats treated with five nongenotoxic carcinogens. PMID: 9372837 |
Ref: Modulation by iron of hepatic microsomal and nuclear cytochrome P450, and cytosolic glutathione S-transferase and peroxidase in C57BL/10ScSn mice induced with polychlorinated biphenyls (Aroclor 1254). PMID: 8560483 Ref: Mouse lung tumors exhibit specific Ki-ras mutations following transplacental exposure to 3-methylcholanthrene. PMID: 8706258 Ref: [Intensity of liver tumor promotion effects in rats given repeated oral administrations of benzimidazole compounds]. PMID: 9037860 |
Ref: Interaction between dose and susceptibility to environmental cancer: a short review. PMID: 9255556 Ref: Studies on the relationship between estrogen receptor content, glutathione S-transferase pi expression, and induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and drug resistance in human breast cancer cells. PMID: 9390189 |
Ref: The use of biochemical and molecular parameters to estimate dose-response relationships at low levels of exposure. PMID: 9539029 Ref: Cytokine-mediated down-regulation of CYP1A1 in Hepa1 cells. PMID: 9714297 Ref: Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene. PMID: 9783729 |
Ref: Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. PMID: 9973208 Ref: Cytochrome P450 1A1 genetic polymorphisms and risk of hepatocellular carcinoma among chronic hepatitis B carriers. PMID: 10408872 Ref: Inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol. PMID: 10496959 |
Ref: Effect of the adrenal 11-beta-hydroxylase inhibitor metyrapone on human hepatic cytochrome P-450 expression: induction of cytochrome P-450 3A4. PMID: 10611146 Ref: Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor. PMID: 10706104 Ref: Mutation frequency in the lacI gene of liver DNA from lambda/lacI transgenic mice following the interaction of PCBs with iron causing hepatic cancer and porphyria. PMID: 10970442 Ref: Influence of beta-naphthoflavone on 7,12-dimethylbenz(a)anthracene metabolism, DNA adduction, and tumorigenicity in rainbow trout. PMID: 11006352 Ref: Induction of cytochrome P450 1A1 in human hepatoma HepG2 cells by 6-nitrochrysene. PMID: 11033235 Ref: Comparative studies on the effects of green tea extracts and individual tea catechins on human CYP1A gene expression. PMID: 11064004 Ref: Expression of cytochrome P450 1A1/2 and 3A4 in liver tissues of hepatocellular carcinoma cases and controls from Taiwan and their relationship to hepatitis B virus and aflatoxin B1-and 4-aminobiphenyl-DNA adducts. PMID: 23885982 |
Ref: Induction and regulation of the carcinogen-metabolizing enzyme CYP1A1 by marijuana smoke and delta (9)-tetrahydrocannabinol. PMID: 11245634 Ref: Differential regulation of cytochrome P450 1A1 and 1B1 by a combination of dioxin and pesticides in the breast tumor cell line MCF-7. PMID: 11358810 |
Ref: Polycyclic aromatic hydrocarbon-DNA adducts in liver tissues of hepatocellular carcinoma patients and controls. PMID: 11948486 Ref: Induction of CYP1A1, CYP1A2, and CYP1B1 mRNAs by nitropolycyclic aromatic hydrocarbons in various human tissue-derived cells: chemical-, cytochrome P450 isoform-, and cell-specific differences. PMID: 12107646 Ref: Characterization of human CYP1A1/1A2 induction by DNA microarray and alpha-naphthoflavone. PMID: 12147246 |
Ref: CYP enzyme polymorphisms and susceptibility to HCV-related chronic liver disease and liver cancer. PMID: 12569554 Ref: CYP1a1, HSP70, P53, and c-fos expression in human liver carcinoma cells (HepG2) exposed to pentachlorophenol. PMID: 12724925 Ref: Aryl hydrocarbon receptor gene silencing with small inhibitory RNA differentially modulates Ah-responsiveness in MCF-7 and HepG2 cancer cells. PMID: 12761348 Ref: Effect of frying-meat emission particulate on 17beta-estradiol 2- and 4-hydroxylation in human lung adenocarcinoma CL5 cells. PMID: 12791542 Ref: Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context. PMID: 14644660 |
Ref: The drug salicylamide is an antagonist of the aryl hydrocarbon receptor that inhibits signal transduction induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. PMID: 14729655 Ref: Lead-induced cytotoxicity and transcriptional activation of stress genes in human liver carcinoma (HepG2) cells. PMID: 14971657 Ref: Modulation of cytochrome P450 1A1 by food-derived heterocyclic aromatic amines. PMID: 15147796 Ref: Cytochrome P450 gene polymorphism and cancer. PMID: 15180491 Ref: Cytochrome p450 gene expression levels in peripheral blood mononuclear cells in comparison with the liver. PMID: 15182434 Ref: Development of rainbow trout hepatoma cell lines: effect of pro-IGF-I Ea4-peptide on morphological changes and anchorage-independent growth. PMID: 15311963 Ref: Polymorphisms of estrogen-metabolizing genes and risk of hepatocellular carcinoma in Taiwan females. PMID: 15341023 Ref: Effects of polybrominated diphenyl ethers on basal and TCDD-induced ethoxyresorufin activity and cytochrome P450-1A1 expression in MCF-7, HepG2, and H4IIE cells. PMID: 15456928 Ref: Cytotoxicity and transcriptional activation of stress genes in human liver carcinoma (HepG2) cells exposed to iprodione. PMID: 16696176 |
Ref: Down-regulation of aryl hydrocarbon receptor-regulated genes by tumor necrosis factor-alpha and lipopolysaccharide in murine hepatoma Hepa 1c1c7 cells. PMID: 15627257 Ref: 5,7-Dimethoxyflavone downregulates CYP1A1 expression and benzo[a]pyrene-induced DNA binding in Hep G2 cells. PMID: 15661813 Ref: Tumor suppressive effects of tocotrienol in vivo and in vitro. PMID: 16098658 |
Ref: Effect of some carcinogenic and non-carcinogenic polycyclic aromatic hydrocarbons on gap junction intercellular communication in hepatoma cell cultures. PMID: 16412531 Ref: Sulindac regulates the aryl hydrocarbon receptor-mediated expression of Phase 1 metabolic enzymes in vivo and in vitro. PMID: 16531450 Ref: 2,3,7,8-Tetrachlorodibenzo-p-dioxin induced cytochrome P450s alter the formation of reactive oxygen species in liver cells. PMID: 16534750 Ref: Regulation of CYP1A1 gene expression by the antioxidant tert-butylhydroquinone. PMID: 16581943 Ref: Quantitative relationship of dioxin-responsive gene expression to dioxin response element in Hep3B and HepG2 human hepatocarcinoma cell lines. PMID: 16697128 Ref: Regulation of the CYP1A1 gene by 2,3,7,8-tetrachlorodibenzo-p-dioxin but not by beta-naphthoflavone or 3-methylcholanthrene is altered in hepatitis C virus replicon-expressing cells. PMID: 16788090 Ref: Calpain mediates the dioxin-induced activation and down-regulation of the aryl hydrocarbon receptor. PMID: 16891617 Ref: Toxicology and carcinogenesis studies of a binary mixture of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) (Cas No. 57465-28-8) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) (CAS No. 35065-27-1) in female Harlan Sprague-Dawley rats (gavage studies). PMID: 17160104 Ref: Toxicology and carcinogenesis studies of a binary mixture of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) (Cas No. 57465-28-8) and 2,3',4,4',5-pentachlorobiphenyl (PCB 118) (Cas No. 31508-00-6) in female Harlan Sprague-Dawley rats (gavage studies). PMID: 17342196 Ref: Identification of CYP2C9*2 allele in HepG2 cell line. PMID: 17827526 |
Ref: The aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl induces distinct patterns of gene expression between hepatoma and glioma cells: chromatin remodeling as a mechanism for selective effects. PMID: 17316808 Ref: 17alpha-Ethinylestradiol decreases expression of multiple hepatic nucleotide excision repair genes in zebrafish (Danio rerio). PMID: 17662478 |
Ref: Effects of coffee and its chemopreventive components kahweol and cafestol on cytochrome P450 and sulfotransferase in rat liver. PMID: 17983700 Ref: Ciprofibrate, clofibric acid and respective glycinate derivatives. Effects of a four-week treatment on male lean and obese Zucker rats. PMID: 18589557 Ref: Black tea polyphenols modulate xenobiotic-metabolizing enzymes, oxidative stress and adduct formation in a rat hepatocarcinogenesis model. PMID: 18985486 Ref: Lack of association between the functional polymorphisms in the estrogen-metabolizing genes and risk for hepatocellular carcinoma. PMID: 19064581 |
Ref: Gamma-ray up-regulated holocarboxylase synthetase gene. PMID: 19048367 Ref: Common genetic variations of the cytochrome P450 1A1 gene and risk of hepatocellular carcinoma in a Chinese population. PMID: 19110417 Ref: Resveratrol inhibits dioxin-induced expression of human CYP1A1 and CYP1B1 by inhibiting recruitment of the aryl hydrocarbon receptor complex and RNA polymerase II to the regulatory regions of the corresponding genes. PMID: 19376845 Ref: Celecoxib enhances the detoxification of diethylnitrosamine in rat liver cancer. PMID: 19452576 Ref: Weight of evidence evaluation of potential human cancer risks from exposure to polychlorinated biphenyls: an update based on studies published since 2003. PMID: 19514916 Ref: Expression of xenobiotic and steroid hormone metabolizing enzymes in hepatocellular tumors of the non-cirrhotic liver. PMID: 19596526 Ref: Interaction between cytochrome P450 1A2 genetic polymorphism and cigarette smoking on the risk of hepatocellular carcinoma in a Japanese population. PMID: 19643819 Ref: The inducibility of human cytochrome P450 1A by environmental-relevant xenobiotics in the human hepatoma derived cell line HepG2. PMID: 21784029 |
Ref: Emodin inhibits the growth of hepatoma cells: finding the common anti-cancer pathway using Huh7, Hep3B, and HepG2 cells. PMID: 19895793 Ref: Peganum harmala L. is a candidate herbal plant for preventing dioxin mediated effects. PMID: 19941261 Ref: The threshold dose for liver tumor promoting effects of dicyclanil in ICR mice. PMID: 20118626 Ref: The role of selected cytochrome P450 enzymes on the bioactivation of aflatoxin B1 by duck liver microsomes. PMID: 20706884 Ref: Functional analysis of six human aryl hydrocarbon receptor variants in human breast cancer and mouse hepatoma cell lines. PMID: 20817071 Ref: Role of retinoic acid in the modulation of benzo(a)pyrene-DNA adducts in human hepatoma cells: implications for cancer prevention. PMID: 20888851 Ref: Toxicology and carcinogenesis studies of 2,3',4,4',5-pentachlorobiphenyl (PCB 118) (CAS No. 31508-00-6) in female harlan Sprague-Dawley rats (gavage studies). PMID: 21383778 |
Ref: Camel urine inhibits the cytochrome P450 1a1 gene expression through an AhR-dependent mechanism in Hepa 1c1c7 cell line. PMID: 20883769 Ref: Relationship between CYP1A induction by indole-3-carbinol or flutamide and liver tumor-promoting potential in rats. PMID: 21203749 Ref: Indole-3-carbinol enhances oxidative stress responses resulting in the induction of preneoplastic liver cell lesions in partially hepatectomized rats initiated with diethylnitrosamine. PMID: 21396975 Ref: Genotoxic effects of the cyanobacterial hepatotoxin cylindrospermopsin in the HepG2 cell line. PMID: 21607682 Ref: Construction and characterization of hepatocyte nuclear factor HNF4alpha1 over-expressing cell line derived from human hepatoma HepG2 cells. PMID: 21871880 |
Ref: Mechanistic study on liver tumor promoting effects of flutamide in rats. PMID: 22076107 Ref: Interactions between CYP1A1 polymorphisms and cigarette smoking are associated with the risk of hepatocellular carcinoma: evidence from epidemiological studies. PMID: 22297691 Ref: Camel milk modulates the expression of aryl hydrocarbon receptor-regulated genes, Cyp1a1, Nqo1, and Gsta1, in murine hepatoma Hepa 1c1c7 cells. PMID: 22570534 Ref: Liver tumor promoting effect of omeprazole in rats and its possible mechanism of action. PMID: 22687989 Ref: Threshold dose of liver tumor promoting effect of beta-naphthoflavone in rats. PMID: 22687991 Ref: Methodological remarks concerning the recent meta-analysis on CYP1A1 polymorphisms-smoking interaction and hepatocellular carcinoma risk. PMID: 22711310 Ref: Expression of genes involved in xenobiotic metabolism and transport in end-stage liver disease: up-regulation of ABCC4 and CYP1B1. PMID: 23087145 |
Ref: Are CYP1A1 polymorphisms associated with the risk of hepatocellular carcinoma? PMID: 23275207 Ref: Cylindrospermopsin induced transcriptional responses in human hepatoma HepG2 cells. PMID: 23726867 Ref: Suppressive effect of liver tumor-promoting activities in rats subjected to combined administration of phenobarbital and piperonyl butoxide. PMID: 24025784 Ref: An aryl hydrocarbon receptor induces VEGF expression through ATF4 under glucose deprivation in HepG2. PMID: 24330582 |
Ref: Association between the CYP1A1 A2455G polymorphism and risk of cancer: evidence from 272 case-control studies. PMID: 24307623 Ref: Association between the CYP1A1 T3801C polymorphism and risk of cancer: evidence from 268 case-control studies. PMID: 24498651 Ref: Short-term effects of oral administration of Pistacia lentiscus oil on tissue-specific toxicity and drug metabolizing enzymes in mice. PMID: 24853661 Ref: Altered gene expression in HepG2 cells exposed to a methanolic coal dust extract. PMID: 25305735 Ref: Enzymes oxidizing the azo dye 1-phenylazo-2-naphthol (Sudan I) and their contribution to its genotoxicity and carcinogenicity. PMID: 25658126 |
Ref: Lineage-dependent effects of aryl hydrocarbon receptor agonists contribute to liver tumorigenesis. PMID: 25284723 Ref: A novel effect of parylene-based surface coating on HepG2 cell function. PMID: 25491976 Ref: The effect of CYP, GST, and SULT polymorphisms and their interaction with smoking on the risk of hepatocellular carcinoma. PMID: 25654087 Ref: Association between the CYP1A1 polymorphisms and hepatocellular carcinoma: a meta-analysis. PMID: 25730047 Ref: Chemopreventive and therapeutic potentials of thymoquinone in HepG2 cells: mechanistic perspectives. PMID: 25796541 Ref: Omeprazole Inhibits Pancreatic Cancer Cell Invasion through a Nongenomic Aryl Hydrocarbon Receptor Pathway. PMID: 25826687 Ref: Mechanistic Investigation of Toxaphene Induced Mouse Liver Tumors. PMID: 26187448 Ref: Screening a mouse liver gene expression compendium identifies modulators of the aryl hydrocarbon receptor (AhR). PMID: 26215100 Ref: Polymorphic Variants of Cytochrome P450: Relevance to Cancer and Other Diseases. PMID: 26233904 Ref: CYP1A1 and CYP1A2 expression levels are differentially regulated in three-dimensional spheroids of liver cancer cells compared to two-dimensional monolayer cultures. PMID: 26643992 |
Ref: Root extract of water dropwort, Oenanthe javanica (Blume) DC, induces protein and gene expression of phase I carcinogen-metabolizing enzymes in HepG2 cells. PMID: 27069833 Ref: Genetic Polymorphisms of Cytochrome P4501A1 (CYP1A1) and Glutathione S-Transferase P1 (GSTP1) and Risk of Hepatocellular Carcinoma Among Chronic Hepatitis C Patients in Egypt. PMID: 27271262 Ref: Methyl isobutyl ketone-induced hepatocellular carcinogenesis in B6C3F1 mice: A constitutive androstane receptor (CAR)-mediated mode of action. PMID: 27664318 Ref: Modulatory effects of rutin on the expression of cytochrome P450s and antioxidant enzymes in human hepatoma cells. PMID: 27749250 |
Ref: Diosmetin Induces Cell Apoptosis by Regulating CYP1A1/CYP1A2 Due to p53 Activation in HepG2 Cells. PMID: 28245756 Ref: Hydroxystilbenes and methoxystilbenes activate human aryl hydrocarbon receptor and induce CYP1A genes in human hepatoma cells and human hepatocytes. PMID: 28279696 Ref: Comparison of the Effects of Monastrol and Oxomonastrol on Human Hepatoma Cell Line HepG2/C3A. PMID: 28314282 Ref: Downregulation of cytochrome P450 2C8 by 3-methylcholanthrene in human hepatocellular carcinoma cell lines. PMID: 28384415 Ref: Activated thyroid hormone receptor modulates dioxin-inducible aryl hydrocarbon receptor-mediated CYP1A1 induction in human hepatocytes but not in human hepatocarcinoma HepG2 cells. PMID: 28478156 Ref: Carbidopa is an activator of aryl hydrocarbon receptor with potential for cancer therapy. PMID: 28963435 |
Ref: Biotransformation and oxidative stress responses in rat hepatic cell-line (H4IIE) exposed to racemic ketoprofen (RS-KP) and its enantiomer, dexketoprofen (S(+)-KP). PMID: 29626791 Ref: The Interaction of Smoking with Gene Polymorphisms on Four Digestive Cancers: A Systematic Review and Meta-Analysis. PMID: 29721061 Ref: Genistein affects expression of cytochrome P450 (CYP450) genes in hepatocellular carcinoma (HEPG2/C3A) cell line. PMID: 29984664 |