Primary Site >> Colorectal Cancer

Gene >> CXCR4

Journal: Exp Nephrol. 2002;10(2):114-9.
Title: Gene expression profiling in silico: relative expression of candidate angiogenesis associated genes in renal cell carcinomas.
Author: Gerritsen, Mary E|Peale, Franklin V Jr|Wu, Thomas
PMID: 11937758
Journal: Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9410-4.
Title: Transepithelial transport of HIV-1 by M cells is receptor-mediated.
Author: Fotopoulos, Grigorios|Harari, Alexandre|Michetti, Pierre|Trono, Didier|Pantaleo, Giuseppe|Kraehenbuhl, Jean-Pierre
PMID: 12093918
Journal: Virology. 2002 Dec 20;304(2):403-14.
Title: Adaptation of a CXCR4-using human immunodeficiency type 1 NDK virus in intestinal cells is associated with CD4-independent replication.
Author: Chenine, Agnes-Laurence|Pion, Marjorie|Matouskova, Eva|Gondois-Rey, Francoise|Vigne, Robert|Hirsch, Ivan
PMID: 12504579
Journal: Cancer Res. 2003 Jul 1;63(13):3833-9.
Title: The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases.
Author: Zeelenberg, Ingrid S|Ruuls-Van Stalle, Lisette|Roos, Ed
PMID: 12839981
Journal: Cancer Immunol Immunother. 2005 Aug;54(8):781-91. Epub 2004 Dec 11.
Title: Inhibitory effects of anti-CXCR4 antibodies on human colon cancer cells.
Author: Ottaiano, Alessandro|di Palma, Antonella|Napolitano, Maria|Pisano, Carmen|Pignata, Sandro|Tatangelo, Fabiana|Botti, Gerardo|Acquaviva, Angela Maria|Castello, Giuseppe|Ascierto, Paolo Antonio|Iaffaioli, Rosario Vincenzo|Scala, Stefania
PMID: 15592929
Journal: Clin Cancer Res. 2005 Mar 1;11(5):1743-50.
Title: Effect of chemokine receptors CXCR4 and CCR7 on the metastatic behavior of human colorectal cancer.
Author: Schimanski, Carl C|Schwald, Stefan|Simiantonaki, Nektaria|Jayasinghe, Caren|Gonner, Ursula|Wilsberg, Vanessa|Junginger, Theodor|Berger, Martin R|Galle, Peter R|Moehler, Markus
PMID: 15755995
Journal: Int J Cancer. 2005 Sep 20;116(5):726-33.
Title: Prediction of lymph node metastasis in colorectal carcinoma by expressionof chemokine receptor CCR7.
Author: Gunther, Klaus|Leier, Julia|Henning, Golo|Dimmler, Arno|Weissbach, Rafael|Hohenberger, Werner|Forster, Reinhold
PMID: 15828050
Journal: J Clin Oncol. 2005 Apr 20;23(12):2744-53.
Title: Chemokine receptor CXCR4 expression in colorectal cancer patients increases the risk for recurrence and for poor survival.
Author: Kim, Joseph|Takeuchi, Hiroya|Lam, Stella T|Turner, Roderick R|Wang, He-Jing|Kuo, Christine|Foshag, Leland|Bilchik, Anton J|Hoon, Dave S B
PMID: 15837989
Journal: Oncology. 2005;68(2-3):276-84. Epub 2005 Jul 7.
Title: Dendritic cells and vascular endothelial growth factor in colorectal cancer: correlations with clinicobiological findings.
Author: Della Porta, Matteo|Danova, Marco|Rigolin, Gian Matteo|Brugnatelli, Silvia|Rovati, Bianca|Tronconi, Chiara|Fraulini, Chiara|Russo Rossi, Antonella|Riccardi, Alberto|Castoldi, Gianluigi
PMID: 16015045
Journal: Exp Cell Res. 2005 Oct 15;310(1):117-30.
Title: CXCR4 and CXCL12 are inversely expressed in colorectal cancer cells and modulate cancer cell migration, invasion and MMP-9 activation.
Author: Brand, Stephan|Dambacher, Julia|Beigel, Florian|Olszak, Torsten|Diebold, Joachim|Otte, Jan-Michel|Goke, Burkhard|Eichhorst, Soren T
PMID: 16125170
Journal: Oncogene. 2006 Aug 17;25(36):4986-97. Epub 2006 Mar 27.
Title: Silencing of epithelial CXCL12 expression by DNA hypermethylation promotes colonic carcinoma metastasis.
Author: Wendt, M K|Johanesen, P A|Kang-Decker, N|Binion, D G|Shah, V|Dwinell, M B
PMID: 16568088
Journal: Tumour Biol. 2006;27(3):166-74.
Title: Involvement of chemokine receptor CCR6 in colorectal cancer metastasis.
Author: Rubie, Claudia|Oliveira, Vilma|Kempf, Katja|Wagner, Mathias|Tilton, Bettina|Rau, Bettina|Kruse, Bianca|Konig, Jochen|Schilling, Martin
PMID: 16641550
Journal: Clin Cancer Res. 2006 May 1;12(9):2795-803.
Title: Overexpression of both CXC chemokine receptor 4 and vascular endothelial growth factor proteins predicts early distant relapse in stage II-III colorectal cancer patients.
Author: Ottaiano, Alessandro|Franco, Renato|Aiello Talamanca, Annarita|Liguori, Giuseppina|Tatangelo, Fabiana|Delrio, Paolo|Nasti, Guglielmo|Barletta, Emiddio|Facchini, Gaetano|Daniele, Bruno|Di Blasi, Arturo|Napolitano, Maria|Ierano, Caterina|Calemma, Rosa|Leona
PMID: 16675573
Journal: Transplantation. 2006 Jun 15;81(11):1558-67.
Title: In vivo luminescent imaging of cyclosporin A-mediated cancer progression in rats.
Author: Ohsawa, Ichiro|Murakami, Takashi|Uemoto, Shinji|Kobayashi, Eiji
PMID: 16770245
Journal: Ann Surg. 2006 Jul;244(1):113-20.
Title: Chemokine receptor CXCR4 expression in patients with melanoma and colorectal cancer liver metastases and the association with disease outcome.
Author: Kim, Joseph|Mori, Takuji|Chen, Steven L|Amersi, Farin F|Martinez, Steve R|Kuo, Christine|Turner, Roderick R|Ye, Xing|Bilchik, Anton J|Morton, Donald L|Hoon, Dave S B
PMID: 16794396
Journal: Int J Cancer. 2006 Nov 1;119(9):2044-53.
Title: Adenosine upregulates CXCR4 and enhances the proliferative and migratory responses of human carcinoma cells to CXCL12/SDF-1alpha.
Author: Richard, Cynthia Lee|Tan, Ernest Yoh|Blay, Jonathan
PMID: 16823836
Journal: World J Gastroenterol. 2006 Nov 7;12(41):6627-33.
Title: Chemokine expression in hepatocellular carcinoma versus colorectal liver metastases.
Author: Rubie, Claudia|Frick, Vilma Oliveira|Wagner, Mathias|Weber, Christina|Kruse, Bianca|Kempf, Katja|Konig, Jochen|Rau, Bettina|Schilling, Martin
PMID: 17075975
Journal: Oncology. 2006;71(3-4):204-11. Epub 2007 Jul 19.
Title: Association between expression of vascular endothelial growth factor C, chemokine receptor CXCR4 and lymph node metastasis in colorectal cancer.
Author: Fukunaga, S|Maeda, K|Noda, E|Inoue, T|Wada, K|Hirakawa, K
PMID: 17641542
Journal: Oncogene. 2007 May 17;26(23):3329-37. Epub 2006 Nov 27.
Title: Negative regulation of chemokine receptor CXCR4 by tumor suppressor p53 in breast cancer cells: implications of p53 mutation or isoform expression on breast cancer cell invasion.
Author: Mehta, S A|Christopherson, K W|Bhat-Nakshatri, P|Goulet, R J Jr|Broxmeyer, H E|Kopelovich, L|Nakshatri, H
PMID: 17130833
Journal: Int J Mol Med. 2007 Jan;19(1):11-5.
Title: Polymorphism and circulating levels of the chemokine CXCL12 in colorectal cancer patients.
Author: Dimberg, Jan|Hugander, Anders|Lofgren, Sture|Wagsater, Dick
PMID: 17143542
Journal: Oncogene. 2007 Jul 12;26(32):4679-88. Epub 2007 Feb 5.
Title: Chemokine receptor CXCR3 promotes colon cancer metastasis to lymph nodes.
Author: Kawada, K|Hosogi, H|Sonoshita, M|Sakashita, H|Manabe, T|Shimahara, Y|Sakai, Y|Takabayashi, A|Oshima, M|Taketo, M M
PMID: 17297455
Journal: Int J Oncol. 2007 May;30(5):1215-22.
Title: Thiazolidinedione drugs down-regulate CXCR4 expression on human colorectal cancer cells in a peroxisome proliferator activated receptor gamma-dependent manner.
Author: Richard, Cynthia Lee|Blay, Jonathan
PMID: 17390024
Journal: Exp Cell Res. 2007 Oct 1;313(16):3446-58. Epub 2007 Jul 13.
Title: 15-Deoxy-delta(12,14)-prostaglandin J(2) down-regulates CXCR4 on carcinoma cells through PPARgamma- and NFkappaB-mediated pathways.
Author: Richard, Cynthia Lee|Lowthers, Erica Lauren|Blay, Jonathan
PMID: 17707368
Journal: Cancer Sci. 2007 Nov;98(11):1652-8.
Title: Chemokine receptors in cancer metastasis and cancer cell-derived chemokines in host immune response.
Author: Koizumi, Keiichi|Hojo, Shozo|Akashi, Takuya|Yasumoto, Kazuo|Saiki, Ikuo
PMID: 17894551
Journal: World J Gastroenterol. 2008 Apr 21;14(15):2308-13.
Title: Inhibition of CXCR4 activity with AMD3100 decreases invasion of human colorectal cancer cells in vitro.
Author: Li, Ji-Kun|Yu, Liang|Shen, Yun|Zhou, Li-Sheng|Wang, Yi-Cheng|Zhang, Jian-Hai
PMID: 18416455
Journal: Br J Cancer. 2008 May 20;98(10):1682-9.
Title: Expression of SDF-1 alpha and nuclear CXCR4 predicts lymph node metastasis in colorectal cancer.
Author: Yoshitake, N|Fukui, H|Yamagishi, H|Sekikawa, A|Fujii, S|Tomita, S|Ichikawa, K|Imura, J|Hiraishi, H|Fujimori, T
PMID: 18443596
Journal: Gastroenterology. 2008 Aug;135(2):508-17.
Title: Constitutive CXCL12 expression induces anoikis in colorectal carcinoma cells.
Author: Wendt, Michael K|Drury, Luke J|Vongsa, Rebecca A|Dwinell, Michael B
PMID: 18558091
Journal: Zhonghua Wei Chang Wai Ke Za Zhi. 2008 Sep;11(5):482-6.
Title: [Expression of chemokine receptor CXCR4 in colorectal carcinoma and its relationship with clinicopathological parameters].
Author: Yu, Liang|Shen, Yun|Li, Ji-Kun|Sun, Yu-Hao|Wang, Yi-Cheng|Zhang, Jian-Hai
PMID: 18803056
Journal: Scand J Immunol. 2008 Dec;68(6):635-44.
Title: Differential CXC receptor expression in colorectal carcinomas.
Author: Rubie, C|Kollmar, O|Frick, V O|Wagner, M|Brittner, B|Graber, S|Schilling, M K
PMID: 18959627
Journal: Cancer Immunol Immunother. 2009 Jan;58(1):85-94.
Title: Expression and function of T cell homing molecules in Hodgkin's lymphoma.
Author: Machado, Lee|Jarrett, Ruth|Morgan, Susan|Murray, Paul|Hunter, Beatrix|Hamilton, Emma|Crocker, John|Thomas, Wendy|Steven, Neil|Ismail, Tariq|Chapman, Ann|Adams, David H|Lee, Steven P
PMID: 18488221
Journal: J Oral Pathol Med. 2009 Feb;38(2):214-9.
Title: CXCR-4 knockdown by small interfering RNA inhibits cell proliferation and invasion of oral squamous cell carcinoma cells.
Author: Hong, Ji-Soo|Pai, Hyun-Kyung|Hong, Kyoung-Ok|Kim, Mi-Ae|Kim, Ji-Hong|Lee, Jae-Il|Hong, Sam-Pyo|Hong, Seong-Doo
PMID: 18624931
Journal: Cell Cycle. 2009 Apr 15;8(8):1228-37. Epub 2009 Apr 23.
Title: A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration.
Author: Ierano, Caterina|Giuliano, Paola|D'Alterio, Crescenzo|Cioffi, Michele|Mettivier, Valentina|Portella, Luigi|Napolitano, Maria|Barbieri, Antonio|Arra, Claudio|Liguori, Giuseppina|Franco, Renato|Palmieri, Giuseppe|Rozzo, Carla|Pacelli, Roberto|Castello, Gius
PMID: 19305148
Journal: Cancer Microenviron. 2009 Dec;2(1):1-7.
Title: Nuclear localization of CXCR4 determines prognosis for colorectal cancer patients.
Author: Speetjens, Frank M|Liefers, Gerrit Jan|Korbee, Cornelis J|Mesker, Wilma E|van de Velde, Cornelis J H|van Vlierberghe, Ronald L|Morreau, Hans|Tollenaar, Rob A|Kuppen, Peter J K
PMID: 19308676
Journal: Clin Colorectal Cancer. 2009 Mar;8(2):100-5.
Title: Brain metastases from colorectal cancer: risk factors, incidence, and the possible role of chemokines.
Author: Mongan, John P|Fadul, Camilo E|Cole, Bernard F|Zaki, Bassem I|Suriawinata, Arief A|Ripple, Gregory H|Tosteson, Tor D|Pipas, J Marc
PMID: 19423503
Journal: Ann Surg Oncol. 2009 Aug;16(8):2323-30.
Title: SDF-1alpha G801A polymorphism predicts lymph node metastasis in stage T3 colorectal cancer.
Author: Chang, Shih-Ching|Lin, Pei-Ching|Yang, Shung-Haur|Wang, Huann-Sheng|Li, Anna Fen-Yau|Lin, Jen-Kou
PMID: 19472013
Journal: Zhonghua Wai Ke Za Zhi. 2009 Feb 1;47(3):210-3.
Title: [Effect of stromal cell-derived factor-1 and its receptor CXCR4 on liver metastasis of human colon cancer].
Author: Ding, Yin-Lu|Fu, Qin-Ye|Tang, Si-Feng|Zhang, Jian-Liang|Li, Zhan-Yuan|Li, Zhao-Ting
PMID: 19563077
Journal: Neoplasia. 2009 Jul;11(7):651-61.
Title: CXCR4 regulates the early extravasation of metastatic tumor cells in vivo.
Author: Gassmann, Peter|Haier, Jorg|Schluter, Kerstin|Domikowsky, Britta|Wendel, Claudia|Wiesner, Ulrike|Kubitza, Robert|Engers, Rainer|Schneider, Stephan W|Homey, Bernhard|Muller, Anja
PMID: 19568410
Journal: Ann Surg Oncol. 2009 Sep;16(9):2645-53.
Title: Hepatic stellate cells promote liver metastasis of colon cancer cells by the action of SDF-1/CXCR4 axis.
Author: Matsusue, Ryo|Kubo, Hajime|Hisamori, Shigeo|Okoshi, Kae|Takagi, Hidekazu|Hida, Koya|Nakano, Keiko|Itami, Atsushi|Kawada, Kenji|Nagayama, Satoshi|Sakai, Yoshiharu
PMID: 19588204
Journal: Zhonghua Zhong Liu Za Zhi. 2009 Apr;31(4):260-4.
Title: [Association of CXCR4 and SDF-1alpha with organ-specific metastasis of nasopharyngeal carcinoma].
Author: Luo, Hua-nan|Li, Xiang-ping|Liu, Xiong|Zhang, Guo-hua|Liu, You-li
PMID: 19615279
Journal: Int J Cancer. 2009 Nov 1;125(9):2187-97.
Title: Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model.
Author: Kunnumakkara, Ajaikumar B|Diagaradjane, Parmeswaran|Anand, Preetha|Harikumar, Kuzhuvelil B|Deorukhkar, Amit|Gelovani, Juri|Guha, Sushovan|Krishnan, Sunil|Aggarwal, Bharat B
PMID: 19623659
Journal: Cancer Biol Ther. 2009 Sep;8(17):1608-14. Epub 2009 Sep 6.
Title: CXCL12, CXCR4 and CXCR7 expression in brain metastases.
Author: Salmaggi, Andrea|Maderna, Emanuela|Calatozzolo, Chiara|Gaviani, Paola|Canazza, Alessandra|Milanesi, Ida|Silvani, Antonio|DiMeco, Francesco|Carbone, Antonino|Pollo, Bianca
PMID: 19625779
Journal: Clin Colorectal Cancer. 2009 Apr;8(2):100-5.
Title: Brain metastases from colorectal cancer: risk factors, incidence, and the possible role of chemokines.
Author: Mongan, John P|Fadul, Camilo E|Cole, Bernard F|Zaki, Bassem I|Suriawinata, Arief A|Ripple, Gregory H|Tosteson, Tor D|Pipas, J Marc
PMID: 19739271
Journal: Cancer Res. 2009 Oct 15;69(20):7905-10.
Title: Direct evidence that bevacizumab, an anti-VEGF antibody, up-regulates SDF1alpha, CXCR4, CXCL6, and neuropilin 1 in tumors from patients with rectal cancer.
Author: Xu, Lei|Duda, Dan G|di Tomaso, Emmanuelle|Ancukiewicz, Marek|Chung, Daniel C|Lauwers, Gregory Y|Samuel, Rekha|Shellito, Paul|Czito, Brian G|Lin, Pei-Chun|Poleski, Martin|Bentley, Rex|Clark, Jeffrey W|Willett, Christopher G|Jain, Rakesh K
PMID: 19826039
Journal: Histopathology. 2009 Nov;55(5):576-86.
Title: The role of vascular CXCR4 expression in colorectal carcinoma.
Author: Ingold, Barbara|Schulz, Stefan|Budczies, Jan|Neumann, Ulf|Ebert, Matthias P A|Weichert, Wilko|Rocken, Christoph
PMID: 19912363
Journal: Zhonghua Wei Chang Wai Ke Za Zhi. 2009 Nov;12(6):627-9.
Title: [Shikonin down-regulates CXCR4 expression and inhibits CXCL12-induced migratory responses in colorectal carcinoma cell line SW480].
Author: Wen, Zhuo-fu|Wei, Xiu-qing|Guo, Yun-wei|Zheng, Feng-ping
PMID: 19921580
Journal: Mol Cell Pharmacol. 2009 Aug 5;1(2):85-91.
Title: HIV Nef-M1 Effects on Colorectal Cancer Growth in Tumor-induced Spleens and Hepatic Metastasis.
Author: Harrington, Willie|Bond, Vincent|Huang, Ming Bo|Powell, Michael|Lillard, James|Manne, Upender|Bumpers, Harvey
PMID: 20383296
Journal: Mol Carcinog. 2010 Jan;49(1):94-103.
Title: Aberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer model.
Author: Borinstein, Scott C|Conerly, Melissa|Dzieciatkowski, Slavomir|Biswas, Swati|Washington, M Kay|Trobridge, Patty|Henikoff, Steve|Grady, William M
PMID: 19777566
Journal: Int J Cancer. 2010 Mar 15;126(6):1302-15.
Title: CXCR4 and CXCR7 regulate angiogenesis and CT26.WT tumor growth independent from SDF-1.
Author: Kollmar, Otto|Rupertus, Kathrin|Scheuer, Claudia|Nickels, Ruth M|Haberl, Gudrun C Y|Tilton, Bettina|Menger, Michael D|Schilling, Martin K
PMID: 19821487
Journal: Ann Surg Oncol. 2010 Aug;17(8):2051-8.
Title: Stromal CXCR4 and CXCL12 expression is associated with distant recurrence and poor prognosis in rectal cancer after chemoradiotherapy.
Author: Saigusa, Susumu|Toiyama, Yuji|Tanaka, Koji|Yokoe, Takeshi|Okugawa, Yoshinaga|Kawamoto, Aya|Yasuda, Hiromi|Inoue, Yasuhiro|Miki, Chikao|Kusunoki, Masato
PMID: 20177796
Journal: Cancer Res. 2010 Jun 1;70(11):4644-54.
Title: Autocrine induction of invasive and metastatic phenotypes by the MIF-CXCR4 axis in drug-resistant human colon cancer cells.
Author: Dessein, Anne-Frederique|Stechly, Laurence|Jonckheere, Nicolas|Dumont, Patrick|Monte, Didier|Leteurtre, Emmanuelle|Truant, Stephanie|Pruvot, Francois-Rene|Figeac, Martin|Hebbar, Mohamed|Lecellier, Charles-Henri|Lesuffleur, Thecla|Dessein, Rodrigue|Grard,
PMID: 20460542
Journal: Int J Colorectal Dis. 2010 Oct;25(10):1185-91.
Title: Nuclear expression of CXCR4 is associated with advanced colorectal cancer.
Author: Wang, Shang-Chiung|Lin, Jen-Kou|Wang, Huann-Sheng|Yang, Shung-Haur|Li, Anna Fen-Yau|Chang, Shih-Ching
PMID: 20607251
Journal: Clin Exp Metastasis. 2010 Oct;27(7):517-27.
Title: CD133(+) single cell-derived progenies of colorectal cancer cell line SW480 with different invasive and metastatic potential.
Author: Li, Guangqiu|Liu, Chao|Yuan, Jian|Xiao, Xiaoqin|Tang, Na|Hao, Junmei|Wang, Hongwei|Bian, Xiuwu|Deng, Yongjian|Ding, Yanqing
PMID: 20617370
Journal: J Clin Invest. 2010 Aug;120(8):2699-714.
Title: Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation.
Author: Imtiyaz, Hongxia Z|Williams, Emily P|Hickey, Michele M|Patel, Shetal A|Durham, Amy C|Yuan, Li-Jun|Hammond, Rachel|Gimotty, Phyllis A|Keith, Brian|Simon, M Celeste
PMID: 20644254
Journal: J Mol Med (Berl). 2010 Dec;88(12):1243-53.
Title: Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor.
Author: Yadav, Vivek R|Sung, Bokyung|Prasad, Sahdeo|Kannappan, Ramaswamy|Cho, Sung-Gook|Liu, Mingyao|Chaturvedi, Madan M|Aggarwal, Bharat B
PMID: 20798912
Journal: Mol Cancer. 2010 Oct 14;9:273.
Title: Macrophages may promote cancer growth via a GM-CSF/HB-EGF paracrine loop that is enhanced by CXCL12.
Author: Rigo, Antonella|Gottardi, Michele|Zamo, Alberto|Mauri, Pierluigi|Bonifacio, Massimiliano|Krampera, Mauro|Damiani, Ernesto|Pizzolo, Giovanni|Vinante, Fabrizio
PMID: 20946648
Journal: Clin Dev Immunol. 2010;2010. pii: 537531.
Title: Clinicopathologic significance of HIF-1alpha, CXCR4, and VEGF expression in colon cancer.
Author: Wu, Yugang|Jin, Min|Xu, Huanbai|Shimin, Zhang|He, Songbing|Wang, Liang|Zhang, Yanyun
PMID: 20953377
Journal: J Surg Res. 2011 Jun 15;168(2):197-205.
Title: Triptolide inhibits proliferation and migration of colon cancer cells by inhibition of cell cycle regulators and cytokine receptors.
Author: Johnson, Sara M|Wang, Xiaofu|Evers, B Mark
PMID: 19922946
Journal: Dig Dis Sci. 2011 Apr;56(4):1194-200.
Title: The expression of both peroxisome proliferator-activated receptor delta and cyclooxygenase-2 in tissues is associated with poor prognosis in colorectal cancer patients.
Author: Yoshinaga, Masahiro|Taki, Kentaro|Somada, Shinichi|Sakiyama, Yumiko|Kubo, Norihiko|Kaku, Toyoma|Tsuruta, Satoru|Kusumoto, Tetsuya|Sakai, Hironori|Nakamura, Kazuhiko|Takayanagi, Ryoichi|Muto, Yoichi
PMID: 20824502
Journal: Tumour Biol. 2011 Feb;32(1):189-96.
Title: Changes in CXCL12/CXCR4-chemokine expression during onset of colorectal malignancies.
Author: Oliveira Frick, Vilma|Rubie, Claudia|Ghadjar, Pirus|Faust, Sabrina K|Wagner, Mathias|Graber, Stefan|Schilling, Martin K
PMID: 20865359
Journal: J Transl Med. 2011 Feb 24;9:22.
Title: CXC receptor-4 mRNA silencing abrogates CXCL12-induced migration of colorectal cancer cells.
Author: Rubie, Claudia|Frick, Vilma O|Ghadjar, Pirus|Wagner, Mathias|Justinger, Christoph|Faust, Sabrina K|Vicinus, Benjamin|Graber, Stefan|Kollmar, Otto|Schilling, Martin K
PMID: 21349176
Journal: World J Gastroenterol. 2011 Feb 7;17(5):625-32.
Title: Influence of CXCR4/SDF-1 axis on E-cadherin/beta-catenin complex expression in HT29 colon cancer cells.
Author: Wang, Lin|Li, Cui-Ling|Wang, Lei|Yu, Wen-Bin|Yin, Hai-Peng|Zhang, Guang-Yong|Zhang, Li-Feng|Li, Sheng|Hu, San-Yuan
PMID: 21350711
Journal: J Nucl Med. 2011 Jun;52(6):986-93.
Title: Imaging CXCR4 expression in human cancer xenografts: evaluation of monocyclam 64Cu-AMD3465.
Author: De Silva, Ravindra A|Peyre, Kevin|Pullambhatla, Mrudula|Fox, James J|Pomper, Martin G|Nimmagadda, Sridhar
PMID: 21622896
Journal: Cancer Manag Res. 2011;3:301-9.
Title: Effects of CXCR4 siRNA/dextran-spermine nanoparticles on CXCR4 expression and serum LDH levels in a mouse model of colorectal cancer metastasis to the liver.
Author: Abedini, Fatemeh|Ismail, Maznah|Hosseinkhani, Hossein|Ibrahim, Tengku Azmi Tengku|Omar, Abdul Rahman|Chong, Pei Pei|Bejo, Mohd Hair|Domb, Abraham J
PMID: 21931504
Journal: Neoplasia. 2011 Sep;13(9):874-86.
Title: Lymph node stromal cells enhance drug-resistant colon cancer cell tumor formation through SDF-1alpha/CXCR4 paracrine signaling.
Author: Margolin, David A|Silinsky, Jennifer|Grimes, Chelsea|Spencer, Nakia|Aycock, Melissa|Green, Heather|Cordova, Jose|Davis, Nancy K|Driscoll, Tiffany|Li, Li
PMID: 21969820
Journal: Onkologie. 2011;34(10):502-8.
Title: A Lentiviral CXCR4 overexpression and knockdown model in colorectal cancer cell lines reveals plerixafor-dependent suppression of SDF-1alpha-induced migration and invasion.
Author: Heckmann, Doreen|Laufs, Stephanie|Maier, Patrick|Zucknick, Manuela|Giordano, Frank A|Veldwijk, Marlon R|Eckstein, Volker|Wenz, Frederik|Zeller, W Jens|Fruehauf, Stefan|Allgayer, Heike
PMID: 21985848
Journal: Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17655-60.
Title: Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways.
Author: Drury, Luke J|Ziarek, Joshua J|Gravel, Stephanie|Veldkamp, Christopher T|Takekoshi, Tomonori|Hwang, Samuel T|Heveker, Nikolaus|Volkman, Brian F|Dwinell, Michael B
PMID: 21990345
Journal: PLoS One. 2011;6(12):e27399.
Title: Alteration of CXCR7 expression mediated by TLR4 promotes tumor cell proliferation and migration in human colorectal carcinoma.
Author: Xu, Huanbai|Wu, Qiong|Dang, Shipeng|Jin, Min|Xu, Jingwei|Cheng, Yiji|Pan, Minglin|Wu, Yugang|Zhang, Chunhui|Zhang, Yanyun
PMID: 22180778
Journal: Invest New Drugs. 2012 Apr;30(2):508-17.
Title: Modulating the interaction of CXCR4 and CXCL12 by low-molecular-weight heparin inhibits hepatic metastasis of colon cancer.
Author: Ma, Lixin|Qiao, Haiquan|He, Changjun|Yang, Qian|Cheung, Chun Hei Antonio|Kanwar, Jagat R|Sun, Xueying
PMID: 21080209
Journal: J Cell Physiol. 2012 Mar;227(3):1114-22.
Title: Stromal cell-derived factor-1/CXC receptor 4 and beta1 integrin interaction regulates urokinase-type plasminogen activator expression in human colorectal cancer cells.
Author: Huang, Wen-Shih|Chin, Chih-Chien|Chen, Cheng-Nan|Kuo, Yi-Hung|Chen, Te-Chuan|Yu, Hong-Ren|Tung, Shui-Yi|Shen, Chien-Heng|Hsieh, Yung-Yu|Guo, Su-Er|Shi, Chung-Sheng|Liu, Ta-Ju|Kuo, Hsing-Chun
PMID: 21567400
Journal: Ann Surg Oncol. 2012 Jul;19 Suppl 3:S339-46.
Title: CXCR4 expression predicts patient outcome and recurrence patterns after hepatic resection for colorectal liver metastases.
Author: Yopp, Adam C|Shia, Jinru|Butte, Jean M|Allen, Peter J|Fong, Yuman|Jarnagin, William R|DeMatteo, Ronald P|D'Angelica, Michael I
PMID: 21584832
Journal: J Oncol. 2012;2012:196957.
Title: Bone Marrow Suppression by c-Kit Blockade Enhances Tumor Growth of Colorectal Metastases through the Action of Stromal Cell-Derived Factor-1.
Author: Rupertus, Kathrin|Haberl, Gudrun C Y|Scheuer, Claudia|Menger, Michael D|Schilling, Martin K|Kollmar, Otto
PMID: 21977032
Journal: Br J Nutr. 2012 Jun;107(11):1623-34.
Title: Oral inoculation of probiotics Lactobacillus acidophilus NCFM suppresses tumour growth both in segmental orthotopic colon cancer and extra-intestinal tissue.
Author: Chen, Chien-Chang|Lin, Wei-Chuan|Kong, Man-Shan|Shi, Hai Ning|Walker, W Allan|Lin, Chun-Yen|Huang, Ching-Tai|Lin, Yung-Chang|Jung, Shih-Ming|Lin, Tzou-Yien
PMID: 21992995
Journal: Clin Exp Metastasis. 2012 Feb;29(2):101-10.
Title: CXCR4/CXCL12 expression profile is associated with tumor microenvironment and clinical outcome of liver metastases of colorectal cancer.
Author: Sakai, Nozomu|Yoshidome, Hiroyuki|Shida, Takashi|Kimura, Fumio|Shimizu, Hiroaki|Ohtsuka, Masayuki|Takeuchi, Dan|Sakakibara, Masahiro|Miyazaki, Masaru
PMID: 22075627
Journal: Lab Invest. 2012 Mar;92(3):420-36.
Title: CD133+ colon cancer cells are more interactive with the tumor microenvironment than CD133- cells.
Author: Chao, Celia|Carmical, J Russ|Ives, Kirk L|Wood, Thomas G|Aronson, Judith F|Gomez, Guillermo A|Djukom, Clarisse D|Hellmich, Mark R
PMID: 22157717
Journal: Curr Mol Med. 2012 Feb;12(2):153-62.
Title: Xanthohumol, a prenylated chalcone derived from hops, suppresses cancer cell invasion through inhibiting the expression of CXCR4 chemokine receptor.
Author: Wang, Y|Chen, Y|Wang, J|Chen, J|Aggarwal, B B|Pang, X|Liu, M
PMID: 22172099
Journal: Cancer Invest. 2012 Jun;30(5):380-9.
Title: Inhibiting CD164 expression in colon cancer cell line HCT116 leads to reduced cancer cell proliferation, mobility, and metastasis in vitro and in vivo.
Author: Tang, Jingqun|Zhang, Liyang|She, Xiaoling|Zhou, Guangqian|Yu, Fenglei|Xiang, Juanjuan|Li, Gang
PMID: 22409183
Journal: J Korean Soc Coloproctol. 2012 Feb;28(1):3-4.
Title: Will the Stroma-derived Factor-1alpha (CXCL12)/CXCR4 Pathway Become a Major Concern for Advanced Colorectal Cancer?
Author: Kim, Hungdai
PMID: 22413073
Journal: BMC Cancer. 2012 Mar 20;12:96.
Title: Characterization of colon cancer cells: a functional approach characterizing CD133 as a potential stem cell marker.
Author: Schneider, Meike|Huber, Johannes|Hadaschik, Boris|Siegers, Gabrielle M|Fiebig, Heinz-Herbert|Schuler, Julia
PMID: 22433494
Journal: BMC Gastroenterol. 2012 May 28;12:53.
Title: The balance between two isoforms of LEF-1 regulates colon carcinoma growth.
Author: Wang, Shu-Hong|Nan, Ke-Jun|Wang, Yao-Chun|Wang, Wen-Juan|Tian, Tao
PMID: 22639890
Journal: Mol Cancer Ther. 2012 Nov;11(11):2516-25.
Title: A locked, dimeric CXCL12 variant effectively inhibits pulmonary metastasis of CXCR4-expressing melanoma cells due to enhanced serum stability.
Author: Takekoshi, Tomonori|Ziarek, Joshua J|Volkman, Brian F|Hwang, Sam T
PMID: 22869557
Journal: BMC Med. 2012 Aug 7;10:85.
Title: CD133(+)CXCR4(+) colon cancer cells exhibit metastatic potential and predict poor prognosis of patients.
Author: Zhang, Shan-shan|Han, Zhi-peng|Jing, Ying-ying|Tao, Shuang-fen|Li, Tie-jun|Wang, Hao|Wang, Yang|Li, Rong|Yang, Yang|Zhao, Xue|Xu, Xiao-dong|Yu, En-da|Rui, Yao-cheng|Liu, Hou-jia|Zhang, Li|Wei, Li-xin
PMID: 22871210
Journal: Int J Nanomedicine. 2012;7:4159-68.
Title: Cationized dextran nanoparticle-encapsulated CXCR4-siRNA enhanced correlation between CXCR4 expression and serum alkaline phosphatase in a mouse model of colorectal cancer.
Author: Abedini, Fatemeh|Hosseinkhani, Hossein|Ismail, Maznah|Domb, Abraham J|Omar, Abdul Rahman|Chong, Pei Pei|Hong, Po-Da|Yu, Dah-Shyong|Farber, Ira-Yudovin
PMID: 22888250
Journal: Int J Nanomedicine. 2012;7:4533-44.
Title: Intracellular CXCR4(+) cell targeting with T22-empowered protein-only nanoparticles.
Author: Unzueta, Ugutz|Cespedes, Maria Virtudes|Ferrer-Miralles, Neus|Casanova, Isolda|Cedano, Juan|Corchero, Jose Luis|Domingo-Espin, Joan|Villaverde, Antonio|Mangues, Ramon|Vazquez, Esther
PMID: 22923991
Journal: Exp Ther Med. 2012 Jun;3(6):973-982.
Title: Co-expression of CXCR4 and CD133 proteins is associated with poor prognosis in stage II-III colon cancer patients.
Author: Zhang, Nian-Hua|Li, Jie|Li, Yin|Zhang, Xin-Tao|Liao, Wen-Ting|Zhang, Jun-Yi|Li, Rong|Luo, Rong-Cheng
PMID: 22970002
Journal: Int J Mol Med. 2012 Dec;30(6):1537-43.
Title: Stromal cell-derived factor-1alpha and macrophage migration-inhibitory factor induce metastatic behavior in CXCR4-expressing colon cancer cells.
Author: Shin, Han-Na|Moon, Hyun-Hye|Ku, Ja-Lok
PMID: 23023114
Journal: PLoS One. 2012;7(10):e47161.
Title: Synergistic antitumor effects of endostar in combination with oxaliplatin via inhibition of HIF and CXCR4 in the colorectal cell line SW1116.
Author: Jin, Fengyan|Ji, Huifan|Jia, Chunshu|Brockmeier, Ulf|Hermann, Dirk M|Metzen, Eric|Zhu, Yingqiao|Chi, Baorong
PMID: 23071744
Journal: J Biomed Sci. 2012 Oct 25;19:91.
Title: CXC chemokine ligand 12/stromal cell-derived factor-1 regulates cell adhesion in human colon cancer cells by induction of intercellular adhesion molecule-1.
Author: Tung, Shui-Yi|Chang, Shun-Fu|Chou, Ming-Hui|Huang, Wen-Shih|Hsieh, Yung-Yu|Shen, Chien-Heng|Kuo, Hsing-Chun|Chen, Cheng-Nan
PMID: 23098564
Journal: Int J Cancer. 2013 Jan 15;132(2):276-87.
Title: The role of CXCR3 and CXCR4 in colorectal cancer metastasis.
Author: Murakami, Teppei|Kawada, Kenji|Iwamoto, Masayoshi|Akagami, Masatoshi|Hida, Koya|Nakanishi, Yuki|Kanda, Keitaro|Kawada, Mayumi|Seno, Hiroshi|Taketo, Makoto Mark|Sakai, Yoshiharu
PMID: 22689289
Journal: J Surg Res. 2013 Jun 1;182(1):75-84.
Title: Hypoxia enhances colon cancer migration and invasion through promotion of epithelial-mesenchymal transition.
Author: Hongo, Kumiko|Tsuno, Nelson H|Kawai, Kazushige|Sasaki, Kazuhito|Kaneko, Manabu|Hiyoshi, Masaya|Murono, Koji|Tada, Noriko|Nirei, Takako|Sunami, Eiji|Takahashi, Koki|Nagawa, Hirokazu|Kitayama, Joji|Watanabe, Toshiaki
PMID: 22959209
Journal: Invest Ophthalmol Vis Sci. 2013 Jan 9;54(1):234-43.
Title: Epigenetic regulation of CXCR4 expression by the ocular microenvironment.
Author: Li, Haochuan|Niederkorn, Jerry Y|Sadegh, Leila|Mellon, Jessamee|Chen, Peter W
PMID: 23188729
Journal: Cancer Biol Ther. 2013 Feb;14(2):175-83.
Title: Histone deacetylase inhibitors induce CXCR4 mRNA but antagonize CXCR4 migration.
Author: Ierano, Caterina|Basseville, Agnes|To, Kenneth K W|Zhan, Zhirong|Robey, Robert W|Wilkerson, Julia|Bates, Susan E|Scala, Stefania
PMID: 23192271
Journal: Cancer Invest. 2013 Feb;31(2):97-102.
Title: Celecoxib downregulates CD133 expression through inhibition of the Wnt signaling pathway in colon cancer cells.
Author: Deng, Yanhong|Su, Qiao|Mo, Jianwen|Fu, Xinhui|Zhang, Yan|Lin, Edward H
PMID: 23245395
Journal: Clin Colorectal Cancer. 2013 Sep;12(3):152-162.e1.
Title: Adenovirus-mediated transcriptional targeting of colorectal cancer and effects on treatment-resistant hypoxic cells.
Author: Rajendran, Simon|O'Sullivan, Gerald C|O'Hanlon, Deirdre|Tangney, Mark
PMID: 23313233
Journal: Clin Exp Metastasis. 2013 Jun;30(5):681-93.
Title: Increased growth of colorectal liver metastasis following partial hepatectomy.
Author: Krause, P|Flikweert, H|Monin, M|Seif Amir Hosseini, A|Helms, G|Cantanhede, G|Ghadimi, B M|Koenig, S
PMID: 23385555
Journal: Transl Oncol. 2013 Apr;6(2):124-32. Epub 2013 Apr 1.
Title: CXCR4 Expression and Treatment with SDF-1alpha or Plerixafor Modulate Proliferation and Chemosensitivity of Colon Cancer Cells.
Author: Heckmann, Doreen|Maier, Patrick|Laufs, Stephanie|Wenz, Frederik|Zeller, W Jens|Fruehauf, Stefan|Allgayer, Heike
PMID: 23544165
Journal: Cancer Gene Ther. 2013 May;20(5):308-16.
Title: The use of hypoxic cultured mesenchymal stem cell for oncolytic virus therapy.
Author: Huang, Y-F|Chen, M-J|Wu, M-H|Hung, S-C
PMID: 23618949
Journal: Inflamm Res. 2013 Jul;62(7):669-80.
Title: Dynamic changes of peritoneal macrophages and subpopulations during ulcerative colitis to metastasis of colorectal carcinoma in a mouse model.
Author: Wang, Wei|Li, Xiayu|Zheng, Danwei|Zhang, Decai|Huang, Shuo|Zhang, Xuemei|Ai, Feiyan|Wang, Xiaoyan|Ma, Jian|Xiong, Wei|Zhou, Yanhong|Li, Guiyuan|Shen, Shourong
PMID: 23625042
Journal: Int J Oncol. 2013 Aug;43(2):425-30.
Title: CD49f-positive cell population efficiently enriches colon cancer-initiating cells.
Author: Haraguchi, Naotsugu|Ishii, Hideshi|Mimori, Koshi|Ohta, Katsuya|Uemura, Mamoru|Nishimura, Junichi|Hata, Taishi|Takemasa, Ichiro|Mizushima, Tsunekazu|Yamamoto, Hirofumi|Doki, Yuichiro|Mori, Masaki
PMID: 23708747
Journal: J Gastrointest Oncol. 2013 Jun;4(2):144-57.
Title: Clinical applications of gene expression in colorectal cancer.
Author: Kheirelseid, Elrasheid A H|Miller, Nicola|Chang, Kah Hoong|Nugent, Mary|Kerin, Michael J
PMID: 23730510
Journal: Mol Cell Biochem. 2013 Sep;381(1-2):233-42.
Title: Expression of miR-126 suppresses migration and invasion of colon cancer cells by targeting CXCR4.
Author: Li, Zeng|Li, Nan|Wu, Minghua|Li, Xiayu|Luo, Zhaohui|Wang, Xiaoyan
PMID: 23744532
Journal: Histopathology. 2013 Aug;63(2):167-73.
Title: The expression of chemokine receptors CCR6, CXCR2 and CXCR4 is not organ-specific for distant metastasis in colorectal cancer: a comparative study.
Author: Hu, Dongzhi|Du, Changzheng|Xue, Weicheng|Dou, Fangyuan|Yao, Yunfeng|Gu, Jin
PMID: 23758411
Journal: Clin Cancer Res. 2013 Aug 15;19(16):4465-76.
Title: Nimbolide, a limonoid triterpene, inhibits growth of human colorectal cancer xenografts by suppressing the proinflammatory microenvironment.
Author: Gupta, Subash C|Prasad, Sahdeo|Sethumadhavan, Dhanya R|Nair, Mangalam S|Mo, Yin-Yuan|Aggarwal, Bharat B
PMID: 23766363
Journal: J Surg Res. 2013 Nov;185(1):113-8.
Title: CD 133+ and CXCR4+ colon cancer cells as a marker for lymph node metastasis.
Author: Silinsky, Jennifer|Grimes, Chelsea|Driscoll, Tiffany|Green, Heather|Cordova, Jose|Davis, Nancy K|Li, Li|Margolin, David A
PMID: 23777983
Journal: J Biomed Res. 2013 Jul;27(4):283-90.
Title: Clinicopathologic significance of CXCR4 and Nrf2 in colorectal cancer.
Author: Hu, Tinghua|Yao, Yu|Yu, Shuo|Guo, Hui|Han, Lili|Wang, Wenjuan|Tian, Tao|Hao, Yibin|Liu, Zhiyan|Nan, Kejun|Wang, Shuhong
PMID: 23885267
Journal: Zhonghua Zhong Liu Za Zhi. 2013 Apr;35(4):277-81.
Title: [Expression of molecular markers detected by immunohistochemistry and risk of lymph node metastasis in stage T1 and T2 colorecrectal cancers].
Author: Wang, Fu-long|Wan, De-sen|Lu, Zhen-hai|Fang, Yu-jing|Li, Li-ren|Chen, Gong|Wu, Xiao-jun|Ding, Pei-rong|Kong, Ling-heng|Lin, Jun-zhong|Pan, Zhi-zhong
PMID: 23985256
Journal: Mol Cancer. 2013 Dec 13;12:164.
Title: miR-133b, a muscle-specific microRNA, is a novel prognostic marker that participates in the progression of human colorectal cancer via regulation of CXCR4 expression.
Author: Duan, Fang-Ting|Qian, Feng|Fang, Ke|Lin, Kang-Yu|Wang, Wen-Tao|Chen, Yue-Qin
PMID: 24330809
Journal: Chin Med J (Engl). 2013;126(24):4747-51.
Title: Effect of CO(2) pneumoperitoneum on the expression of the chemokine receptors CXCR4 and CCR7 in colorectal carcinoma cells in vitro.
Author: Yang, Chun-Kang|Li, Guo-Dong|Ying, Min-Gang|Xu, Ke
PMID: 24342323
Journal: Carcinogenesis. 2014 Feb;35(2):282-91.
Title: SDF-1/CXCR4 axis promotes directional migration of colorectal cancer cells through upregulation of integrin alphavbeta6.
Author: Wang, Ben|Wang, Wenke|Niu, Weibo|Liu, Enyu|Liu, Xiangjuan|Wang, Jiayong|Peng, Cheng|Liu, Song|Xu, Ling|Wang, Lei|Niu, Jun
PMID: 24085800
Journal: J Magn Reson Imaging. 2014 Jun;39(6):1436-42.
Title: Rectal cancer: dynamic contrast-enhanced MRI correlates with lymph node status and epidermal growth factor receptor expression.
Author: Lollert, Andre|Junginger, Theodor|Schimanski, Carl Christoph|Biesterfeld, Stefan|Gockel, Ines|Duber, Christoph|Oberholzer, Katja
PMID: 24127411
Journal: Int J Oncol. 2014 Jan;44(1):203-10.
Title: MicroRNA-126 functions as a tumor suppressor in colorectal cancer cells by targeting CXCR4 via the AKT and ERK1/2 signaling pathways.
Author: Liu, Yaling|Zhou, Yu|Feng, Xiao|An, Ping|Quan, Xiaojing|Wang, Hao|Ye, Shicai|Yu, Caiyuan|He, Yanting|Luo, Hesheng
PMID: 24189753
Journal: Clin Cancer Res. 2014 Feb 1;20(3):604-16.
Title: The disparate twins: a comparative study of CXCR4 and CXCR7 in SDF-1alpha-induced gene expression, invasion and chemosensitivity of colon cancer.
Author: Heckmann, Doreen|Maier, Patrick|Laufs, Stephanie|Li, Li|Sleeman, Jonathan P|Trunk, Marcus J|Leupold, Jorg H|Wenz, Frederik|Zeller, W Jens|Fruehauf, Stefan|Allgayer, Heike
PMID: 24255072
Journal: Int J Cancer. 2014 Jul 15;135(2):379-90.
Title: A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients.
Author: D'Alterio, Crescenzo|Avallone, Antonio|Tatangelo, Fabiana|Delrio, Paolo|Pecori, Biagio|Cella, Laura|Pelella, Alessia|D'Armiento, Francesco Paolo|Carlomagno, Chiara|Bianco, Franco|Silvestro, Lucrezia|Pacelli, Roberto|Napolitano, Maria|Iaffaioli, Rosario Vi
PMID: 24375277
Journal: Tumour Biol. 2014 May;35(5):4171-5.
Title: CXCR4 as a novel predictive biomarker for metastasis and poor prognosis in colorectal cancer.
Author: Gao, Ying|Li, Chunyu|Nie, Min|Lu, Yao|Lin, Shunsen|Yuan, Peng|Sun, Xun
PMID: 24395653
Journal: Histopathology. 2014 Apr;64(5):701-12.
Title: The association of CXCR4 expression with prognosis and clinicopathological indicators in colorectal carcinoma patients: a meta-analysis.
Author: Lv, Shunzeng|Yang, Yakun|Kwon, Sera|Han, Mingzhi|Zhao, Fangfang|Kang, Huihui|Dai, Congxin|Wang, Renzhi
PMID: 24422942
Journal: Clin Exp Metastasis. 2014 Apr;31(4):447-59.
Title: Interaction of the chemokines I-TAC (CXCL11) and SDF-1 (CXCL12) in the regulation of tumor angiogenesis of colorectal cancer.
Author: Rupertus, Kathrin|Sinistra, Janine|Scheuer, Claudia|Nickels, Ruth M|Schilling, Martin K|Menger, Michael D|Kollmar, Otto
PMID: 24493023
Journal: Genes Chromosomes Cancer. 2014 Apr;53(4):358-65.
Title: Low expression of microRNA-126 is associated with poor prognosis in colorectal cancer.
Author: Liu, Yaling|Zhou, Yu|Feng, Xiao|Yang, Pengchun|Yang, Jingfang|An, Ping|Wang, Hao|Ye, Shicai|Yu, Caiyuan|He, Yanting|Luo, Hesheng
PMID: 24532280
Journal: Mol Cancer. 2014 Mar 14;13:58.
Title: Hypoxia differentially regulated CXCR4 and CXCR7 signaling in colon cancer.
Author: Romain, Benoit|Hachet-Haas, Muriel|Rohr, Serge|Brigand, Cecile|Galzi, Jean-Luc|Gaub, Marie-Pierre|Pencreach, Erwan|Guenot, Dominique
PMID: 24629239
Journal: Int J Oncol. 2014 Jun;44(6):1861-9.
Title: The influence of lentivirus-mediated CXCR4 RNA interference on hepatic metastasis of colorectal cancer.
Author: Wang, Tian-Bao|Hu, Bao-Guang|Liu, Da-Wei|Shi, Han-Ping|Dong, Wen-Guang
PMID: 24647809
Journal: Oncol Rep. 2014 Jul;32(1):79-88.
Title: Inhibitor of DNA-binding protein 1 knockdown arrests the growth of colorectal cancer cells and suppresses hepatic metastasis in vivo.
Author: Lai, Xiaolan|Liao, Jinrong|Lin, Wansong|Huang, Chuanzhong|Li, Jieyu|Lin, Jizhen|Chen, Qiang|Ye, Yunbin
PMID: 24804700
Journal: Cancer Lett. 2014 Nov 28;354(2):417-26.
Title: SDF-1/CXCR4 promotes epithelial-mesenchymal transition and progression of colorectal cancer by activation of the Wnt/beta-catenin signaling pathway.
Author: Hu, Ting-Hua|Yao, Yu|Yu, Shuo|Han, Li-Li|Wang, Wen-Juan|Guo, Hui|Tian, Tao|Ruan, Zhi-Pin|Kang, Xiao-Min|Wang, Jing|Wang, Shu-Hong|Nan, Ke-Jun
PMID: 25150783
Journal: Biochem Biophys Res Commun. 2014 Oct 24;453(3):486-92.
Title: IL-33/ST2 pathway contributes to metastasis of human colorectal cancer.
Author: Liu, Xuejian|Zhu, Leilei|Lu, Xin|Bian, Hairong|Wu, Xia|Yang, Wenchuan|Qin, Qingliang
PMID: 25280997
Journal: PLoS One. 2014 Nov 14;9(11):e112580.
Title: Hypoxia-inducible factors modulate the stemness and malignancy of colon cancer cells by playing opposite roles in canonical Wnt signaling.
Author: Santoyo-Ramos, Paula|Likhatcheva, Maria|Garcia-Zepeda, Eduardo A|Castaneda-Patlan, M Cristina|Robles-Flores, Martha
PMID: 25396735
Journal: Nan Fang Yi Ke Da Xue Xue Bao. 2014 Nov;34(11):1684-7.
Title: [Expression of methionine sulfoxide reductase in colorectal cancer stem cells in vitro].
Author: Xue, Fangqin|Yang, Guohua|Huang, Ruolei
PMID: 25413075
Journal: Hepatology. 2015 Jan;61(1):238-48.
Title: Tissue inhibitor of metalloproteinases (TIMP)-1 creates a premetastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice.
Author: Seubert, Bastian|Grunwald, Barbara|Kobuch, Julia|Cui, Haissi|Schelter, Florian|Schaten, Susanne|Siveke, Jens T|Lim, Ngee H|Nagase, Hideaki|Simonavicius, Nicole|Heikenwalder, Mathias|Reinheckel, Thomas|Sleeman, Jonathan P|Janssen, Klaus-Peter|Knolle, Percy
PMID: 25131778
Journal: Clin Transl Oncol. 2015 Apr;17(4):322-9.
Title: Gene expression differences in primary colorectal tumors and matched liver metastases: chemotherapy related or tumoral heterogeneity?
Author: Lopez-Gomez, M|Moreno-Rubio, J|Suarez-Garcia, I|Cejas, P|Madero, R|Casado, E|Jimenez, A M|Sereno, M|Gomez-Raposo, C|Zambrana, F|Merino, M|Fernandez-Luengas, D|Feliu, J
PMID: 25301403
Journal: FASEB J. 2015 Feb;29(2):464-76.
Title: Higher metastatic efficiency of KRas G12V than KRas G13D in a colorectal cancer model.
Author: Alamo, Patricia|Gallardo, Alberto|Di Nicolantonio, Federica|Pavon, Miguel Angel|Casanova, Isolda|Trias, Manuel|Mangues, Maria Antonia|Lopez-Pousa, Antonio|Villaverde, Antonio|Vazquez, Esther|Bardelli, Alberto|Cespedes, Maria Virtudes|Mangues, Ramon
PMID: 25359494
Journal: Mol Cancer Ther. 2015 Feb;14(2):480-90.
Title: Identification of LY2510924, a novel cyclic peptide CXCR4 antagonist that exhibits antitumor activities in solid tumor and breast cancer metastatic models.
Author: Peng, Sheng-Bin|Zhang, Xiaoyi|Paul, Donald|Kays, Lisa M|Gough, Wendy|Stewart, Julie|Uhlik, Mark T|Chen, Qi|Hui, Yu-Hua|Zamek-Gliszczynski, Maciej J|Wijsman, John A|Credille, Kelly M|Yan, Liang Zeng
PMID: 25504752
Journal: Curr Pharm Des. 2015;21(17):2276-83.
Title: CXCR4 and CXCL12 Expression in Rectal Tumors of Stage IV Patients Before and After Local Radiotherapy and Systemic Neoadjuvant Treatment.
Author: Tamas, Karin|Domanska, Urszula M|van Dijk, Tonnis H|Timmer-Bosscha, Hetty|Havenga, Klaas|Karrenbeld, Arend|Sluiter, Wim J|Beukema, Jannet C|van Vugt, Marcel A T M|de Vries, Elisabeth G E|Hospers, Geke A P|Walenkamp, Annemiek M E
PMID: 25557636
Journal: Cancer Sci. 2015 Mar;106(3):262-9.
Title: Overexpression of chemokine receptor CXCR2 and ligand CXCL7 in liver metastases from colon cancer is correlated to shorter disease-free and overall survival.
Author: Desurmont, Thibault|Skrypek, Nicolas|Duhamel, Alain|Jonckheere, Nicolas|Millet, Guillaume|Leteurtre, Emmanuelle|Gosset, Pierre|Duchene, Belinda|Ramdane, Nassima|Hebbar, Mohamed|Van Seuningen, Isabelle|Pruvot, Francois-Rene|Huet, Guillemette|Truant, Stepha
PMID: 25580640
Journal: Oncotarget. 2015 Mar 10;6(7):5022-40.
Title: CXCR4 over-expression and survival in cancer: a system review and meta-analysis.
Author: Zhao, Hongli|Guo, Liyuan|Zhao, Hong|Zhao, Jiaxin|Weng, Hao|Zhao, Bin
PMID: 25669980
Journal: Asian Pac J Cancer Prev. 2015;16(3):1073-6.
Title: Effect of CXCR4 and CD133 co-expression on the prognosis of patients with stage II~III colon cancer.
Author: Li, Xiao-Feng|Guo, Xiao-Guang|Yang, Yong-Yan|Liu, Ai-Yong
PMID: 25735334
Journal: Oncol Rep. 2015 May;33(5):2445-53.
Title: Investigation of the roles of exosomes in colorectal cancer liver metastasis.
Author: Wang, Xia|Ding, Xiaoling|Nan, Lijuan|Wang, Yiting|Wang, Jing|Yan, Zhiqiang|Zhang, Wei|Sun, Jihong|Zhu, Wei|Ni, Bing|Dong, Suzhen|Yu, Lei
PMID: 25760247
Journal: Oncol Rep. 2015 Jun;33(6):2681-8.
Title: Activation of platelet protease-activated receptor-1 induces epithelial-mesenchymal transition and chemotaxis of colon cancer cell line SW620.
Author: Jia, Yitao|Zhang, Suqiao|Miao, Lingling|Wang, Jingbao|Jin, Zujian|Gu, Bin|Duan, Zhihui|Zhao, Zhaolong|Ma, Shunmao|Zhang, Wenjin|Li, Zhongxin
PMID: 25846512
Journal: J Pathol. 2015 Aug;236(4):467-78.
Title: SEMA3F prevents metastasis of colorectal cancer by PI3K-AKT-dependent down-regulation of the ASCL2-CXCR4 axis.
Author: Zhou, Zhi-hang|Rao, Jun|Yang, Jing|Wu, Feng|Tan, Juan|Xu, Sen-lin|Ding, Yanqing|Zhan, Na|Hu, Xu-gang|Cui, You-hong|Zhang, Xia|Dong, Weiguo|Liu, Xin-dong|Bian, Xiu-wu
PMID: 25866254
Journal: BMC Cancer. 2015 Apr 10;15:250.
Title: Curcumin potentiates antitumor activity of 5-fluorouracil in a 3D alginate tumor microenvironment of colorectal cancer.
Author: Shakibaei, Mehdi|Kraehe, Patricia|Popper, Bastian|Shayan, Parviz|Goel, Ajay|Buhrmann, Constanze
PMID: 25884903
Journal: Cancer Prev Res (Phila). 2015 Jul;8(7):614-9.
Title: TFF2-CXCR4 Axis Is Associated with BRAF V600E Colon Cancer.
Author: Gala, Manish K|Austin, Thomas|Ogino, Shuji|Chan, Andrew T
PMID: 25899003
Journal: Biomed Pharmacother. 2015 Apr;71:46-52.
Title: Downregulation of the CXCR4/CXCL12 axis blocks the activation of the Wnt/beta-catenin pathway in human colon cancer cells.
Author: Song, Zhi-Yu|Gao, Zu-Hua|Chu, Jia-Hui|Han, Xiu-Zhen|Qu, Xian-Jun
PMID: 25960214
Journal: FASEB J. 2015 Aug;29(8):3571-81.
Title: The critical roles of tumor-initiating cells and the lymph node stromal microenvironment in human colorectal cancer extranodal metastasis using a unique humanized orthotopic mouse model.
Author: Margolin, David A|Myers, Tamara|Zhang, Xin|Bertoni, Danielle M|Reuter, Brian A|Obokhare, Izi|Borgovan, Theodor|Grimes, Chelsea|Green, Heather|Driscoll, Tiffany|Lee, Chung-Gi|Davis, Nancy K|Li, Li
PMID: 25962655
Journal: Asian Pac J Cancer Prev. 2015;16(9):4077-80.
Title: Prognosis and Clinicopathology of CXCR4 in Colorectal Cancer Patients: a Meta-analysis.
Author: Li, Lu-Ning|Jiang, Kai-Tong|Tan, Peng|Wang, Ai-Hua|Kong, Qing-Yin|Wang, Cui-Yue|Lu, Hua-Rong|Wang, Jing
PMID: 25987090
Journal: Sci Rep. 2015 May 28;5:10357.
Title: Identification of a distinct population of CD133(+)CXCR4(+) cancer stem cells in ovarian cancer.
Author: Cioffi, Michele|D'Alterio, Crescenzo|Camerlingo, Rosalba|Tirino, Virginia|Consales, Claudia|Riccio, Anna|Ierano, Caterina|Cecere, Sabrina Chiara|Losito, Nunzia Simona|Greggi, Stefano|Pignata, Sandro|Pirozzi, Giuseppe|Scala, Stefania
PMID: 26020117
Journal: Biomed Res Int. 2015;2015:326981.
Title: Role of B7-H4 siRNA in Proliferation, Migration, and Invasion of LOVO Colorectal Carcinoma Cell Line.
Author: Peng, Hai-Xia|Wu, Wei-Qi|Yang, Da-Ming|Jing, Rong|Li, Ji|Zhou, Feng-Li|Jin, Yun-Fei|Wang, Sai-Yu|Chu, Yi-Min
PMID: 26078947
Journal: Oncotarget. 2015 Sep 29;6(29):27763-77.
Title: Nef-M1, a peptide antagonist of CXCR4, inhibits tumor angiogenesis and epithelialtomesenchymal transition in colon and breast cancers.
Author: Katkoori, Venkat R|Basson, Marc D|Bond, Vincent C|Manne, Upender|Bumpers, Harvey L
PMID: 26318034
Journal: Pathologe. 2015 Nov;36 Suppl 2:185-8.
Title: [The metastatic niche. Mechanisms and prognostic implications].
Author: Muders, M H|Baretton, G B
PMID: 26395891
Journal: Cancer Biomark. 2015;15(6):869-79.
Title: Stromal cell derived factor-1 and CXCR4 expression in colorectal cancer promote liver metastasis.
Author: Amara, Sameh|Chaar, Ines|Khiari, Meriem|Ounissi, Donia|Weslati, Marwa|Boughriba, Rahma|Hmida, Abdelmajid B|Bouraoui, Saadia
PMID: 26406413
Journal: BMC Cancer. 2015 Nov 10;15:882.
Title: Chemotherapeutic agents attenuate CXCL12-mediated migration of colon cancer cells by selecting for CXCR4-negative cells and increasing peptidase CD26.
Author: Cutler, Murray J|Lowthers, Erica L|Richard, Cynthia L|Hajducek, Dagmar M|Spagnuolo, Paul A|Blay, Jonathan
PMID: 26552750
Journal: Arkh Patol. 2015 Sep-Oct;77(5):26-30.
Title: [Prognostic values of the clinical, morphological and molecular biological characteristics of colon adenocarcinoma].
Author: Raskin, G A|Pozharissky, K M|Orlova, R V|Petrov, S V
PMID: 26978017
Journal: Tumour Biol. 2016 Jun;37(6):7441-52.
Title: CXCR4, CXCL12 and the relative CXCL12-CXCR4 expression as prognostic factors in colon cancer.
Author: Stanisavljevic, Luka|Assmus, Jorg|Storli, Kristian Eeg|Leh, Sabine Maria|Dahl, Olav|Myklebust, Mette Pernille
PMID: 26678887
Journal: Ann Surg Oncol. 2016 May;23(5):1601-8.
Title: Angiogenesis-Related Markers and Prognosis After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Metastatic Colorectal Cancer.
Author: de Cuba, E M V|de Hingh, I H J T|Sluiter, N R|Kwakman, R|Coupe, V M H|Belien, J A M|Verwaal, V J|Meijerink, W J H J|Delis-van Diemen, P M|Bonjer, H J|Meijer, G A|Te Velde, E A
PMID: 26727921
Journal: Cancer Res. 2016 Jan 15;76(2):347-57.
Title: Peritoneal Dissemination Requires an Sp1-Dependent CXCR4/CXCL12 Signaling Axis and Extracellular Matrix-Directed Spheroid Formation.
Author: Kasagi, Yuta|Harada, Yui|Morodomi, Yosuke|Iwai, Toshiki|Saito, Satoru|Yoshida, Kumi|Oki, Eiji|Saeki, Hiroshi|Ohgaki, Kippei|Sugiyama, Masahiko|Onimaru, Mitsuho|Maehara, Yoshihiko|Yonemitsu, Yoshikazu
PMID: 26744523
Journal: Nat Commun. 2016 Feb 4;7:10517.
Title: Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer.
Author: Dubeykovskaya, Zina|Si, Yiling|Chen, Xiaowei|Worthley, Daniel L|Renz, Bernhard W|Urbanska, Aleksandra M|Hayakawa, Yoku|Xu, Ting|Westphalen, C Benedikt|Dubeykovskiy, Alexander|Chen, Duan|Friedman, Richard A|Asfaha, Samuel|Nagar, Karan|Tailor, Yagnesh|Muthu
PMID: 26841680
Journal: Sci Rep. 2016 Feb 11;6:20896.
Title: Inhibition of Growth and Metastasis of Colon Cancer by Delivering 5-Fluorouracil-loaded Pluronic P85 Copolymer Micelles.
Author: Zhu, Pengxi|Zhao, Naping|Sheng, Dandan|Hou, Jing|Hao, Chong|Yang, Xue|Zhu, Bing|Zhang, Shanshan|Han, Zhipeng|Wei, Lixin|Zhang, Li
PMID: 26864651
Journal: Nutrients. 2016 Mar 5;8(3):145.
Title: Sirt1 Is Required for Resveratrol-Mediated Chemopreventive Effects in Colorectal Cancer Cells.
Author: Buhrmann, Constanze|Shayan, Parviz|Popper, Bastian|Goel, Ajay|Shakibaei, Mehdi
PMID: 26959057
Journal: Oncol Rep. 2016 May;35(5):2615-23.
Title: Curcumin inhibits tumor epithelialmesenchymal transition by downregulating the Wnt signaling pathway and upregulating NKD2 expression in colon cancer cells.
Author: Zhang, Zewei|Chen, Haitao|Xu, Chao|Song, Lu|Huang, Lulu|Lai, Yuebiao|Wang, Yuqi|Chen, Hanlu|Gu, Danlin|Ren, Lili|Yao, Qinghua
PMID: 26985708
Journal: Oncol Lett. 2016 Mar;11(3):1873-1878.
Title: Analysis of the expression of SDF-1 splicing variants in human colorectal cancer and normal mucosa tissues.
Author: Allami, Risala Hussain|Graf, Claudine|Martchenko, Ksenia|Voss, Beatrice|Becker, Marc|Berger, Martin R|Galle, Peter R|Theobald, Matthias|Wehler, Thomas C|Schimanski, Carl C
PMID: 26998092
Journal: Microb Cell Fact. 2016 Apr 8;15:59.
Title: Structural and functional features of self-assembling protein nanoparticles produced in endotoxin-free Escherichia coli.
Author: Rueda, Fabian|Cespedes, Maria Virtudes|Sanchez-Chardi, Alejandro|Seras-Franzoso, Joaquin|Pesarrodona, Mireia|Ferrer-Miralles, Neus|Vazquez, Esther|Rinas, Ursula|Unzueta, Ugutz|Mamat, Uwe|Mangues, Ramon|Garcia-Fruitos, Elena|Villaverde, Antonio
PMID: 27059706
Journal: Nanomedicine. 2016 Oct;12(7):1987-1996.
Title: Cancer-specific uptake of a liganded protein nanocarrier targeting aggressive CXCR4(+) colorectal cancer models.
Author: Cespedes, Maria Virtudes|Unzueta, Ugutz|Alamo, Patricia|Gallardo, Alberto|Sala, Rita|Casanova, Isolda|Pavon, Miguel Angel|Mangues, Maria Antonia|Trias, Manuel|Lopez-Pousa, Antonio|Villaverde, Antonio|Vazquez, Esther|Mangues, Ramon
PMID: 27085904
Journal: J Transl Med. 2016 May 12;14(1):133.
Title: Ex-vivo characterization of circulating colon cancer cells distinguished in stem and differentiated subset provides useful biomarker for personalized metastatic risk assessment.
Author: Malara, Natalia|Trunzo, Valentina|Foresta, Umberto|Amodio, Nicola|De Vitis, Stefania|Roveda, Laura|Fava, Mariagiovanna|Coluccio, MariaLaura|Macri, Roberta|Di Vito, Anna|Costa, Nicola|Mignogna, Chiara|Britti, Domenico|Palma, Ernesto|Mollace, Vincenzo
PMID: 27176720
Journal: Int J Mol Sci. 2016 Jun 14;17(6). pii: ijms17060903.
Title: The Effect of Analogues of 1alpha,25-Dihydroxyvitamin D(2) on the Regrowth and Gene Expression of Human Colon Cancer Cells Refractory to 5-Fluorouracil.
Author: Neska, Jacek|Swoboda, Pawel|Przybyszewska, Malgorzata|Kotlarz, Agnieszka|Bolla, Narasimha Rao|Miloszewska, Joanna|Grygorowicz, Monika Anna|Kutner, Andrzej|Markowicz, Sergiusz
PMID: 27314328
Journal: Onco Targets Ther. 2016 Jun 1;9:3307-12.
Title: The prognostic role of serum C-X-C chemokine receptor type 4 in patients with metastatic or recurrent colorectal cancer.
Author: Choi, Yoon Ji|Chang, Won Jin|Shin, Sang Won|Park, Kyong Hwa|Kim, Seung Tae|Kim, Yeul Hong
PMID: 27330310
Journal: Oncotarget. 2016 Aug 2;7(31):49834-49847.
Title: High expression of WISP1 in colon cancer is associated with apoptosis, invasion and poor prognosis.
Author: Wu, Jianghong|Long, Ziwen|Cai, Hong|Du, Chunyan|Liu, Xiaowen|Yu, Shengjia|Wang, Yanong
PMID: 27409174
Journal: Oncotarget. 2016 Sep 13;7(37):60230-60244.
Title: MicroRNA-126 inhibits colon cancer cell proliferation and invasion by targeting the chemokine (C-X-C motif) receptor 4 and Ras homolog gene family, member A, signaling pathway.
Author: Yuan, Wei|Guo, Ye-Qing|Li, Xia-Yu|Deng, Min-Zi|Shen, Zhao-Hua|Bo, Chi-Bin|Dai, Ya-Fei|Huang, Ming-Yu|Yang, Zhen-Yu|Quan, Yong-Sheng|Tian, Li|Wang, Xiaoyan
PMID: 27517626
Journal: J Med Chem. 2016 Sep 22;59(18):8369-80.
Title: Exploring the N-Terminal Region of C-X-C Motif Chemokine 12 (CXCL12): Identification of Plasma-Stable Cyclic Peptides As Novel, Potent C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonists.
Author: Di Maro, Salvatore|Trotta, Anna Maria|Brancaccio, Diego|Di Leva, Francesco Saverio|La Pietra, Valeria|Ierano, Caterina|Napolitano, Maria|Portella, Luigi|D'Alterio, Crescenzo|Siciliano, Rosa Anna|Sementa, Deborah|Tomassi, Stefano|Carotenuto, Alfonso|Novell
PMID: 27571038
Journal: Br J Cancer. 2016 Sep 27;115(7):814-24.
Title: gamma-Tocotrienol suppresses growth and sensitises human colorectal tumours to capecitabine in a nude mouse xenograft model by down-regulating multiple molecules.
Author: Prasad, Sahdeo|Gupta, Subash C|Tyagi, Amit K|Aggarwal, Bharat B
PMID: 27575851
Journal: Biomed Pharmacother. 2016 Dec;84:191-198.
Title: BACH1 silencing by siRNA inhibits migration of HT-29 colon cancer cells through reduction of metastasis-related genes.
Author: Davudian, Sadaf|Shajari, Neda|Kazemi, Tohid|Mansoori, Behzad|Salehi, Shima|Mohammadi, Ali|Shanehbandi, Dariush|Shahgoli, Vahid Khaze|Asadi, Milad|Baradaran, Behzad
PMID: 27657827
Journal: PLoS One. 2016 Sep 26;11(9):e0159927.
Title: The Association of CXC Receptor 4 Mediated Signaling Pathway with Oxaliplatin-Resistant Human Colorectal Cancer Cells.
Author: Huang, Wen-Shih|Hsieh, Meng-Chiao|Huang, Cheng-Yi|Kuo, Yi-Hung|Tung, Shui-Yi|Shen, Chien-Heng|Hsieh, Yung-Yu|Teng, Chih-Chuan|Lee, Kam-Fai|Chen, Te-Chuan|Lee, Ko-Chao|Kuo, Hsing-Chun
PMID: 27668882
Journal: Oncotarget. 2016 Dec 6;7(49):81144-81155.
Title: Co-expression of Lgr5 and CXCR4 characterizes cancer stem-like cells of colorectal cancer.
Author: Wu, Weidong|Cao, Jun|Ji, Zhengyi|Wang, Jingjue|Jiang, Tao|Ding, Honghua
PMID: 27835894
Journal: Oncotarget. 2016 Dec 6;7(49):81223-81240.
Title: Prognostic significance of USP33 in advanced colorectal cancer patients: new insights into beta-arrestin-dependent ERK signaling.
Author: Liu, Hongda|Zhang, Qun|Li, Kangshuai|Gong, Zheng|Liu, Zhaochen|Xu, Yunfei|Swaney, Mary Hannah|Xiao, Kunhong|Chen, Yuxin
PMID: 27835898
Journal: Oncoimmunology. 2016 Nov 29;5(12):e1254313.
Title: CXCR4-CXCL12-CXCR7, TLR2-TLR4, and PD-1/PD-L1 in colorectal cancer liver metastases from neoadjuvant-treated patients.
Author: D'Alterio, Crescenzo|Nasti, Guglielmo|Polimeno, Marianeve|Ottaiano, Alessandro|Conson, Manuel|Circelli, Luisa|Botti, Giovanni|Scognamiglio, Giosue|Santagata, Sara|De Divitiis, Chiara|Nappi, Anna|Napolitano, Maria|Tatangelo, Fabiana|Pacelli, Roberto|Izzo,
PMID: 28123896
Journal: Cold Spring Harb Symp Quant Biol. 2016;81:219-226.
Title: Explaining the Paucity of Intratumoral T Cells: A Construction Out of Known Entities.
Author: Fearon, Douglas T
PMID: 28389597
Journal: Cell Adh Migr. 2017 Jan 2;11(1):13-23.
Title: LPS-induced CXCR4-dependent migratory properties and a mesenchymal-like phenotype of colorectal cancer cells.
Author: Liu, Wen-Ting|Jing, Ying-Ying|Yan, Fei|Han, Zhi-Peng|Lai, Fo-Bao|Zeng, Jian-Xing|Yu, Guo-Feng|Fan, Qing-Min|Li, Rong|Zhao, Qiu-Dong|Wu, Meng-Chao|Wei, Li-Xin
PMID: 26745593
Journal: Integr Cancer Ther. 2017 Jun;16(2):244-251.
Title: Onbaekwon Suppresses Colon Cancer Cell Invasion by Inhibiting Expression of the CXC Chemokine Receptor 4.
Author: Kim, Buyun|Yoon, Jaewoo|Yoon, Seong Woo|Park, Byoungduck
PMID: 27160279
Journal: Hum Exp Toxicol. 2017 Jul;36(7):692-700.
Title: Garcinol exhibits anti-proliferative activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells.
Author: Ranjbarnejad, T|Saidijam, M|Tafakh, M Sadat|Pourjafar, M|Talebzadeh, F|Najafi, R
PMID: 27481098
Journal: Clin Cancer Res. 2017 Jan 15;23(2):549-561.
Title: ADAM17 is a Tumor Promoter and Therapeutic Target in Western Diet-associated Colon Cancer.
Author: Mustafi, Reba|Dougherty, Urszula|Mustafi, Devkumar|Ayaloglu-Butun, Fatma|Fletcher, Michelle|Adhikari, Sarbani|Sadiq, Farhana|Meckel, Katherine|Haider, Haider I|Khalil, Abdurahman|Pekow, Joel|Konda, Vani|Joseph, Loren|Hart, John|Fichera, Alessandro|Li, Yan
PMID: 27489286
Journal: Curr Stem Cell Res Ther. 2017;12(1):19-30.
Title: Role of Stem Cells in Colorectal Cancer Progression and Prognostic and Predictive Characteristics of Stem Cell Markers in Colorectal Cancer.
Author: Fedyanin, Mikhail|Anna, Popova|Elizaveta, Polyanskaya|Sergei, Tjulandin
PMID: 27593447
Journal: Exp Biol Med (Maywood). 2017 Feb;242(4):429-435.
Title: Activation of CXCL12/CXCR4 renders colorectal cancer cells less sensitive to radiotherapy via up-regulating the expression of survivin.
Author: Wang, Dawei|Jiao, Chengbin|Zhu, Yanli|Liang, Deshen|Zao, Ming|Meng, Xiangyu|Gao, Jianwei|He, Yunlong|Liu, Weixin|Hou, Jie|Zhong, Zhaohua|Cheng, Zhuoxin
PMID: 27798120
Journal: BMC Cancer. 2017 Jan 7;17(1):33.
Title: miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway.
Author: Kuroda, Kengo|Fukuda, Tomokazu|Krstic-Demonacos, Marija|Demonacos, Constantinos|Okumura, Kazuhiko|Isogai, Hiroshi|Hayashi, Miwa|Saito, Kazuki|Isogai, Emiko
PMID: 28061765
Journal: Sci Rep. 2017 Feb 8;7:42226.
Title: CXCL12/CXCR4 axis induced miR-125b promotes invasion and confers 5-fluorouracil resistance through enhancing autophagy in colorectal cancer.
Author: Yu, Xinfeng|Shi, Wenna|Zhang, Yuhang|Wang, Xiaohui|Sun, Shiyue|Song, Zhiyu|Liu, Man|Zeng, Qiao|Cui, Shuxiang|Qu, Xianjun
PMID: 28176874
Journal: Mol Clin Oncol. 2017 May;6(5):701-704.
Title: Expression of CXCR-4 and IDO in human colorectal cancer: An immunohistochemical approach.
Author: Ogawa, Masaichi|Watanabe, Michiaki|Hasegawa, Takuo|Ichihara, Kohei|Yoshida, Kazuhiko|Yanaga, Katsuhiko
PMID: 28515923
Journal: Prostaglandins Other Lipid Mediat. 2017 Jul;131:1-8.
Title: Methanolic extract of Boswellia serrata exhibits anti-cancer activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells.
Author: Ranjbarnejad, Tayebeh|Saidijam, Massoud|Moradkhani, Shirin|Najafi, Rezvan
PMID: 28549801
Journal: Pathol Res Pract. 2017 Jul;213(7):783-792.
Title: Clinicopathologic and prognostic significance of immunohistochemical expression of HIF-1alpha, CXCR4 and CA9 in colorectal carcinoma.
Author: Saka, Burcu|Ekinci, Ozgur|Dursun, Ayse|Akyurek, Nalan
PMID: 28554753
Journal: Tumour Biol. 2017 Jun;39(6):1010428317706206.
Title: Role of CXCR4 and SDF1 as prognostic factors for survival and the association with clinicopathology in colorectal cancer: A systematic meta-analysis.
Author: Li, Yao-Ping|Pang, Jing|Gao, Sheng|Bai, Peng-Yu|Wang, Wen-da|Kong, Pengzhou|Cui, Yongping
PMID: 28621237
Journal: Anticancer Res. 2017 Aug;37(8):4361-4369.
Title: The Axis of CXCR4/SDF-1 Plays a Role in Colon Cancer Cell Adhesion Through Regulation of the AKT and IGF1R Signalling Pathways.
Author: Zheng, Fei|Zhang, Zhongtao|Flamini, Valentina|Jiang, Wen G|Cui, Yuxin
PMID: 28739729
Journal: Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):10455-10460.
Title: Targeting CXCR4-dependent immunosuppressive Ly6C(low) monocytes improves antiangiogenic therapy in colorectal cancer.
Author: Jung, Keehoon|Heishi, Takahiro|Incio, Joao|Huang, Yuhui|Beech, Elizabeth Y|Pinter, Matthias|Ho, William W|Kawaguchi, Kosuke|Rahbari, Nuh N|Chung, Euiheon|Kim, Jun Ki|Clark, Jeffrey W|Willett, Christopher G|Yun, Seok Hyun|Luster, Andrew D|Padera, Timothy P
PMID: 28900008
Journal: Biochem Biophys Res Commun. 2017 Nov 4;493(1):461-467.
Title: Identification of hypoxia-regulated angiogenic genes in colorectal cancer.
Author: Zong, Shaoqi|Li, Wen|Li, Hongjia|Han, Susu|Liu, Shanshan|Shi, Qi|Hou, Fenggang
PMID: 28928094
Journal: Cell Oncol (Dordr). 2017 Dec;40(6):609-619.
Title: Phosphorylated CXCR4 expression has a positive prognostic impact in colorectal cancer.
Author: Weixler, B|Renetseder, F|Facile, I|Tosti, N|Cremonesi, E|Tampakis, A|Delko, T|Eppenberger-Castori, S|Tzankov, A|Iezzi, G|Kettelhack, C|Soysal, S D|von Holzen, U|Spagnoli, G C|Terracciano, L|Tornillo, L|Droeser, Raoul A|Daster, S
PMID: 28936810
Journal: Oncol Lett. 2017 Nov;14(5):5831-5838.
Title: Ginkgolic acid inhibits the invasiveness of colon cancer cells through AMPK activation.
Author: Qiao, Lina|Zheng, Jianbao|Jin, Xianzhen|Wei, Guangbing|Wang, Guanghui|Sun, Xuejun|Li, Xuqi
PMID: 29113214
Journal: Int J Mol Sci. 2017 Nov 8;18(11). pii: ijms18112363.
Title: Effect of AICAR and 5-Fluorouracil on X-ray Repair, Cross-Complementing Group 1 Expression, and Consequent Cytotoxicity Regulation in Human HCT-116 Colorectal Cancer Cells.
Author: Lee, Ko-Chao|Lin, Chien-Tsong|Chang, Shun-Fu|Chen, Cheng-Nan|Liu, Jing-Lan|Huang, Wen-Shih
PMID: 29117108
Journal: Cell Biol Toxicol. 2018 Aug;34(4):263-277.
Title: Mst1 regulates colorectal cancer stress response via inhibiting Bnip3-related mitophagy by activation of JNK/p53 pathway.
Author: Li, Qi|Qi, Feng|Meng, Xiangchao|Zhu, Chenpei|Gao, Yingtang
PMID: 29063978
Journal: Br J Cancer. 2018 Jan;118(2):224-232.
Title: ALDH1A3 affects colon cancer in vitro proliferation and invasion depending on CXCR4 status.
Author: Feng, Hailiang|Liu, Yanyan|Bian, Xiaocui|Zhou, Fangying|Liu, Yuqin
PMID: 29235568
Journal: Mol Med Rep. 2018 Mar;17(3):3775-3782.
Title: Identification of crucial genes associated with Parkinson's disease using microarray data.
Author: Sun, Yongqi|Ye, Linlin|Zheng, Yonghui|Yang, Zichao
PMID: 29257331
Journal: J Control Release. 2018 Mar 28;274:81-92.
Title: Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs.
Author: Sanchez-Garcia, Laura|Serna, Naroa|Alamo, Patricia|Sala, Rita|Cespedes, Maria Virtudes|Roldan, Monica|Sanchez-Chardi, Alejandro|Unzueta, Ugutz|Casanova, Isolda|Mangues, Ramon|Vazquez, Esther|Villaverde, Antonio
PMID: 29408658
Journal: Oncol Rep. 2018 Apr;39(4):2022-2030.
Title: CXCR4 receptor blockage reduces the contribution of tumor and stromal cells to the metastatic growth in the liver.
Author: Benedicto, Aitor|Romayor, Irene|Arteta, Beatriz
PMID: 29436696
Journal: Biochem Biophys Res Commun. 2018 May 5;499(2):120-127.
Title: BACH1 promotes the progression of human colorectal cancer through BACH1/CXCR4 pathway.
Author: Zhu, Guo-Dong|Liu, Feng|OuYang, Shi|Zhou, Rui|Jiang, Fu-Neng|Zhang, Bei|Liao, Wang-Jun
PMID: 29481800
Journal: J Control Release. 2018 Jun 10;279:29-39.
Title: Release of targeted protein nanoparticles from functional bacterial amyloids: A death star-like approach.
Author: Unzueta, Ugutz|Cespedes, Maria Virtudes|Sala, Rita|Alamo, Patricia|Sanchez-Chardi, Alejandro|Pesarrodona, Mireia|Sanchez-Garcia, Laura|Cano-Garrido, Olivia|Villaverde, Antonio|Vazquez, Esther|Mangues, Ramon|Seras-Franzoso, Joaquin
PMID: 29641987
Journal: Oncotarget. 2018 Feb 28;9(21):15691-15704.
Title: Loss of neutrophil polarization in colon carcinoma liver metastases of mice with an inducible, liver-specific IGF-I deficiency.
Author: Rayes, Roni F|Milette, Simon|Fernandez, Maria Celia|Ham, Boram|Wang, Ni|Bourdeau, France|Perrino, Stephanie|Yakar, Shoshana|Brodt, Pnina
PMID: 29644002
Journal: Life Sci. 2018 Sep 1;208:333-340.
Title: CXCR4 overexpression is correlated with poor prognosis in colorectal cancer.
Author: Xu, Chao|Zheng, Linfeng|Li, Dechuan|Chen, Guoping|Gu, Jianzhong|Chen, Jun|Yao, Qinghua
PMID: 29719205
Journal: Clin Lab. 2018 May 1;64(5):871-876.
Title: Expression Patterns of CXCL12 and its Receptor in Colorectal Carcinoma.
Author: Mousavi, Ashraf|Hashemzadeh, Shahryar|Bahrami, Tayyeb|Estiar, Mehrdad Asghari|Feizi, Mohammad A H|Pouladi, Nasser|Rostamizadeh, Leila|Sakhinia, Ebrahim
PMID: 29739049
Journal: Gastroenterol Res Pract. 2018 May 16;2018:9613185.
Title: Clinicopathologic Significance of CXCL12 and CXCR4 Expressions in Patients with Colorectal Cancer.
Author: Yoshuantari, Naomi|Heriyanto, Didik Setyo|Hutajulu, Susanna Hilda|Kurnianda, Johan|Ghozali, Ahmad
PMID: 29887884
Journal: Biol Cell. 2018 Jun 15.
Title: Laminin alpha1 orchestrates VEGFA functions in the ecosystem of colorectal carcinoma.
Author: Mammadova-Bach, Elmina|Rupp, Tristan|Spenle, Caroline|Jivkov, Ivo|Shankaranarayanan, Pattabhiraman|Klein, Annick|Pisarsky, Laura|Mechine-Neuville, Agnes|Cremel, Gerard|Kedinger, Michele|De Wever, Olivier|Ambartsumian, Noona|Robine, Sylvie|Pencreach, Erwan
PMID: 29907957
Journal: Nutrients. 2018 Jul 12;10(7). pii: nu10070888.
Title: Resveratrol Chemosensitizes TNF-beta-Induced Survival of 5-FU-Treated Colorectal Cancer Cells.
Author: Buhrmann, Constanze|Yazdi, Mina|Popper, Bastian|Shayan, Parviz|Goel, Ajay|Aggarwal, Bharat B|Shakibaei, Mehdi
PMID: 30002278
Journal: Cells Tissues Organs. 2018 Jul 24:1-8.
Title: Sulforaphane, a Chemopreventive Compound, Inhibits Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 Expression in Human HT-29 Colon Cancer Cells.
Author: Tafakh, Maryam Sadat|Saidijam, Massoud|Ranjbarnejad, Tayebeh|Malih, Sara|Mirzamohammadi, Solmaz|Najafi, Rezvan
PMID: 30041241
Journal: Exp Cell Res. 2018 Oct 1;371(1):162-174.
Title: CXCR3 expression in colorectal cancer cells enhanced invasion through preventing CXCR4 internalization.
Author: Jin, Jingjing|Zhang, Zhan|Wang, Haowen|Zhan, Yu|Li, Gang|Yang, Han|Fei, Zhenghua|Xu, Yunsheng|Li, Wenfeng
PMID: 30092218
Journal: BMC Cancer. 2018 Aug 24;18(1):848.
Title: ALDH1A3 upregulation and spontaneous metastasis formation is associated with acquired chemoresistance in colorectal cancer cells.
Author: Durinikova, Erika|Kozovska, Zuzana|Poturnajova, Martina|Plava, Jana|Cierna, Zuzana|Babelova, Andrea|Bohovic, Roman|Schmidtova, Silvia|Tomas, Miroslav|Kucerova, Lucia|Matuskova, Miroslava
PMID: 30143021
Journal: EMBO Mol Med. 2018 Sep 6. pii: emmm.201708772.
Title: Selective depletion of metastatic stem cells as therapy for human colorectal cancer.
Author: Cespedes, Maria Virtudes|Unzueta, Ugutz|Avino, Anna|Gallardo, Alberto|Alamo, Patricia|Sala, Rita|Sanchez-Chardi, Alejandro|Casanova, Isolda|Mangues, Maria Antonia|Lopez-Pousa, Antonio|Eritja, Ramon|Villaverde, Antonio|Vazquez, Esther|Mangues, Ramon
PMID: 30190334
Journal: Mol Cancer Ther. 2018 Oct 18. pii: 1535-7163.MCT-18-0104.
Title: A Unique Non-Saccharide Mimetic of Heparin Hexasaccharide Inhibits Colon Cancer Stem Cells via p38 MAP Kinase Activation.
Author: Boothello, Rio S|Patel, Nirmita J|Sharon, Chetna|Abdelfadiel, Elsamani I|Morla, Shravan|Brophy, Donald F|Lippman, H Robert|Desai, Umesh R|Patel, Bhaumik B
PMID: 30337351
Journal: Oncogene. 2018 Oct 18. pii: 10.1038/s41388-018-0519-2.
Title: CXCR7/CXCR4 heterodimer-induced histone demethylation: a new mechanism of colorectal tumorigenesis.
Author: Song, Zhi-Yu|Wang, Feng|Cui, Shu-Xiang|Gao, Zu-Hua|Qu, Xian-Jun
PMID: 30337690
Journal: Biosci Rep. 2018 Oct 24. pii: BSR20180243.
Title: Integrin alphavbeta6 Plays an Bi-directional Regulation Role Between Colon Cancer cells and Cancer-Associated Fibroblasts.
Author: Peng, Cheng|Zou, Xueqing|Xia, Wanying|Gao, Huijie|Li, Zequn|Liu, Naiqing|Xu, Zongquan|Gao, Chao|He, Zhaobin|Niu, Weibo|Fang, Ruliang|Biswas, Siddhartha|Agrez, Michael|Zhi, Xuting|Niu, Jun
PMID: 30355650
Journal: Med Sci Monit. 2018 Oct 28;24:7710-7718.
Title: Knockdown of MON1B Exerts Anti-Tumor Effects in Colon Cancer In Vitro.
Author: Jiang, Lai|Qian, Jun|Yang, Yongbo|Fan, Yongtian
PMID: 30368516