Primary Site >> Colorectal Cancer

Gene >> CXCR2

Journal: Clin Cancer Res. 2001 Oct;7(10):3298-304.
Title: Expression of interleukin 8 and its receptors in human colon carcinoma cells with different metastatic potentials.
Author: Li, A|Varney, M L|Singh, R K
PMID: 11595728
Journal: Exp Cell Res. 2004 Oct 1;299(2):315-24.
Title: The epithelial-mesenchymal transition of colon carcinoma involves expression of IL-8 and CXCR-1-mediated chemotaxis.
Author: Bates, Richard C|DeLeo, Michael J 3rd|Mercurio, Arthur M
PMID: 15350531
Journal: Clin Exp Metastasis. 2004;21(7):571-9.
Title: Constitutive expression of growth regulated oncogene (gro) in human colon carcinoma cells with different metastatic potential and its role in regulating their metastatic phenotype.
Author: Li, Aihua|Varney, Michelle L|Singh, Rakesh K
PMID: 15787094
Journal: Int J Cancer. 2005 Aug 20;116(2):275-81.
Title: Dendritic cells delivered inside human carcinomas are sequestered by interleukin-8.
Author: Feijoo, Esperanza|Alfaro, Carlos|Mazzolini, Guillermo|Serra, Patricia|Penuelas, Ivan|Arina, Ainhoa|Huarte, Eduardo|Tirapu, Inigo|Palencia, Belen|Murillo, Oihana|Ruiz, Juan|Sangro, Bruno|Richter, Jose A|Prieto, Jesus|Melero, Ignacio
PMID: 15800914
Journal: Clin Colorectal Cancer. 2005 Jul;5(2):124-31.
Title: Gene polymorphisms of epidermal growth factor receptor and its downstream effector, interleukin-8, predict oxaliplatin efficacy in patients with advanced colorectal cancer.
Author: Zhang, Wu|Stoehlmacher, Jan|Park, David J|Yang, Dongyun|Borchard, Erin|Gil, Ji|Tsao-Wei, Denice D|Yun, Jim|Gordon, Michael|Press, Oliver A|Rhodes, Katrin|Groshen, Susan|Lenz, Heinz-Josef
PMID: 16098254
Journal: Ann Surg Oncol. 2006 Feb;13(2):263-75. Epub 2006 Jan 20.
Title: Macrophage inflammatory protein-2 promotes angiogenesis, cell migration, and tumor growth in hepatic metastasis.
Author: Kollmar, Otto|Scheuer, Claudia|Menger, Michael D|Schilling, Martin K
PMID: 16424980
Journal: Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):5951-9.
Title: GROalpha is highly expressed in adenocarcinoma of the colon and down-regulates fibulin-1.
Author: Wen, Yu|Giardina, Sarah F|Hamming, David|Greenman, Jennifer|Zachariah, Emmanuel|Bacolod, Manny D|Liu, Hao|Shia, Jinru|Amenta, Peter S|Barany, Francis|Paty, Phillip|Gerald, William|Notterman, Daniel
PMID: 17062666
Journal: Eur J Surg Oncol. 2007 Aug;33(6):803-11. Epub 2007 Feb 20.
Title: Studies on MIP-2 and CXCR2 expression in a mouse model of extrahepatic colorectal metastasis.
Author: Kollmar, O|Junker, B|Rupertus, K|Menger, M D|Schilling, M K
PMID: 17314027
Journal: J Surg Res. 2008 Apr;145(2):295-302. Epub 2007 Jun 11.
Title: Liver resection-associated macrophage inflammatory protein-2 stimulates engraftment but not growth of colorectal metastasis at extrahepatic sites.
Author: Kollmar, Otto|Junker, Bastian|Rupertus, Kathrin|Scheuer, Claudia|Menger, Michael D|Schilling, Martin K
PMID: 17561115
Journal: BMC Cancer. 2008 Jun 25;8:178.
Title: ELR+ CXC chemokine expression in benign and malignant colorectal conditions.
Author: Rubie, Claudia|Frick, Vilma Oliveira|Wagner, Mathias|Schuld, Jochen|Graber, Stefan|Brittner, Brigitte|Bohle, Rainer M|Schilling, Martin K
PMID: 18578857
Journal: Cancer Res. 2008 Dec 1;68(23):9754-62.
Title: TSU68 prevents liver metastasis of colon cancer xenografts by modulating the premetastatic niche.
Author: Yamamoto, Masayoshi|Kikuchi, Hirotoshi|Ohta, Manabu|Kawabata, Toshiki|Hiramatsu, Yoshihiro|Kondo, Kenji|Baba, Megumi|Kamiya, Kinji|Tanaka, Tatsuo|Kitagawa, Masatoshi|Konno, Hiroyuki
PMID: 19047154
Journal: Gastrointest Cancer Res. 2008 Jul;2(4 Suppl):S38-41.
Title: Individualization of therapy for colorectal cancer based on clinical and molecular parameters.
Author: Pohl, Alexandra|Lenz, Heinz-Josef
PMID: 19343148
Journal: Methods Enzymol. 2009;460:105-21.
Title: Expression of chemokines and chemokine receptors in human colon cancer.
Author: Erreni, Marco|Bianchi, Paolo|Laghi, Luigi|Mirolo, Massimiliano|Fabbri, Marco|Locati, Massimo|Mantovani, Alberto|Allavena, Paola
PMID: 19446722
Journal: Oncol Rep. 2010 Dec;24(6):1479-86.
Title: GROalpha promotes invasion of colorectal cancer cells.
Author: Ogata, Hideo|Sekikawa, Akira|Yamagishi, Hidetsugu|Ichikawa, Kazuhito|Tomita, Shigeki|Imura, Johji|Ito, Yuichi|Fujita, Masanori|Tsubaki, Masahiro|Kato, Hiroyuki|Fujimori, Takahiro|Fukui, Hirokazu
PMID: 21042742
Journal: Cancer Lett. 2011 Jan 28;300(2):180-8.
Title: Small molecule antagonists for CXCR2 and CXCR1 inhibit human colon cancer liver metastases.
Author: Varney, Michelle L|Singh, Seema|Li, Aihua|Mayer-Ezell, Rosemary|Bond, Richard|Singh, Rakesh K
PMID: 21035946
Journal: PLoS One. 2011 Mar 14;6(3):e17922.
Title: Carcinoma-derived interleukin-8 disorients dendritic cell migration without impairing T-cell stimulation.
Author: Alfaro, Carlos|Suarez, Natalia|Martinez-Forero, Ivan|Palazon, Asis|Rouzaut, Ana|Solano, Sarai|Feijoo, Esperanza|Gurpide, Alfonso|Bolanos, Elixabet|Erro, Lorena|Dubrot, Juan|Hervas-Stubbs, Sandra|Gonzalez, Alvaro|Perez-Gracia, Jose Luis|Melero, Ignacio
PMID: 21423807
Journal: Br J Cancer. 2011 Feb 1;104(3):480-7.
Title: The expression and prognostic impact of CXC-chemokines in stage II and III colorectal cancer epithelial and stromal tissue.
Author: Oladipo, O|Conlon, S|O'Grady, A|Purcell, C|Wilson, C|Maxwell, P J|Johnston, P G|Stevenson, M|Kay, E W|Wilson, R H|Waugh, D J J
PMID: 21285972
Journal: J Pediatr Gastroenterol Nutr. 2012 Mar;54(3):414-21.
Title: Neutrophil transintestinal epithelial migration to CXCR2 ligands is regulated by adenosine.
Author: Stadnyk, Andrew W|Carrigan, Svetlana O|Otley, Anthony R
PMID: 21857250
Journal: Eur J Cancer. 2012 Sep;48(14):2244-51.
Title: CXCL5, a promoter of cell proliferation, migration and invasion, is a novel serum prognostic marker in patients with colorectal cancer.
Author: Kawamura, Mikio|Toiyama, Yuji|Tanaka, Kouji|Saigusa, Susumu|Okugawa, Yoshinaga|Hiro, Junichiro|Uchida, Keiichi|Mohri, Yasuhiko|Inoue, Yasuhiro|Kusunoki, Masato
PMID: 22197219
Journal: Med Oncol. 2012 Dec;29(4):2466-72.
Title: High expression of CXCR2 is associated with tumorigenesis, progression, and prognosis of laryngeal squamous cell carcinoma.
Author: Han, Liang|Jiang, Bin|Wu, Hao|Wang, Xudong|Tang, Xiaojun|Huang, Jianfei|Zhu, Jin
PMID: 22274915
Journal: Mol Cancer Ther. 2012 Jun;11(6):1353-64.
Title: The CXCR2 antagonist, SCH-527123, shows antitumor activity and sensitizes cells to oxaliplatin in preclinical colon cancer models.
Author: Ning, Yan|Labonte, Melissa J|Zhang, Wu|Bohanes, Pierre O|Gerger, Armin|Yang, Dongyun|Benhaim, Leonor|Paez, David|Rosenberg, David O|Nagulapalli Venkata, Kalyan C|Louie, Stan G|Petasis, Nicos A|Ladner, Robert D|Lenz, Heinz-Josef
PMID: 22391039
Journal: Expert Opin Ther Targets. 2012 May;16(5):491-7.
Title: Targeting IL-8 in colorectal cancer.
Author: Ning, Yan|Lenz, Heinz-Josef
PMID: 22494524
Journal: Br J Cancer. 2012 May 22;106(11):1833-41.
Title: Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis.
Author: Lee, Y S|Choi, I|Ning, Y|Kim, N Y|Khatchadourian, V|Yang, D|Chung, H K|Choi, D|LaBonte, M J|Ladner, R D|Nagulapalli Venkata, K C|Rosenberg, D O|Petasis, N A|Lenz, H-J|Hong, Y-K
PMID: 22617157
Journal: Anesthesiology. 2012 Aug;117(2):293-301.
Title: Volatile anesthetics reduce invasion of colorectal cancer cells through down-regulation of matrix metalloproteinase-9.
Author: Muller-Edenborn, Bjorn|Roth-Z'graggen, Birgit|Bartnicka, Kamila|Borgeat, Alain|Hoos, Alexandra|Borsig, Lubor|Beck-Schimmer, Beatrice
PMID: 22739763
Journal: PLoS One. 2012;7(12):e51848.
Title: Crucial involvement of tumor-associated neutrophils in the regulation of chronic colitis-associated carcinogenesis in mice.
Author: Shang, Kun|Bai, Yu-Pan|Wang, Chen|Wang, Zhen|Gu, Hong-Yu|Du, Xiang|Zhou, Xiao-Yan|Zheng, Chun-Lei|Chi, Ya-Yun|Mukaida, Naofumi|Li, Ying-Yi
PMID: 23272179
Journal: Integr Biol (Camb). 2013 Oct;5(10):1272-81.
Title: Single cells from human primary colorectal tumors exhibit polyfunctional heterogeneity in secretions of ELR+ CXC chemokines.
Author: Adalsteinsson, Viktor A|Tahirova, Narmin|Tallapragada, Naren|Yao, Xiaosai|Campion, Liam|Angelini, Alessandro|Douce, Thomas B|Huang, Cindy|Bowman, Brittany|Williamson, Christina A|Kwon, Douglas S|Wittrup, K Dane|Love, J Christopher
PMID: 23995780
Journal: Gastroenterology. 2013 Jan;144(1):155-66.
Title: Mice that express human interleukin-8 have increased mobilization of immature myeloid cells, which exacerbates inflammation and accelerates colon carcinogenesis.
Author: Asfaha, Samuel|Dubeykovskiy, Alexander N|Tomita, Hiroyuki|Yang, Xiangdong|Stokes, Sarah|Shibata, Wataru|Friedman, Richard A|Ariyama, Hiroshi|Dubeykovskaya, Zinaida A|Muthupalani, Sureshkumar|Ericksen, Russell|Frucht, Harold|Fox, James G|Wang, Timothy C
PMID: 23041326
Journal: Int J Cancer. 2013 Feb 15;132(4):905-15.
Title: Interleukin genes and associations with colon and rectal cancer risk and overall survival.
Author: Bondurant, Kristina L|Lundgreen, Abbie|Herrick, Jennifer S|Kadlubar, Susan|Wolff, Roger K|Slattery, Martha L
PMID: 22674296
Journal: Histopathology. 2013 Aug;63(2):167-73.
Title: The expression of chemokine receptors CCR6, CXCR2 and CXCR4 is not organ-specific for distant metastasis in colorectal cancer: a comparative study.
Author: Hu, Dongzhi|Du, Changzheng|Xue, Weicheng|Dou, Fangyuan|Yao, Yunfeng|Gu, Jin
PMID: 23758411
Journal: Int J Cancer. 2014 Jul 1;135(1):232-7.
Title: CXCR2 inhibition enhances sulindac-mediated suppression of colon cancer development.
Author: Lee, Yong Suk|Choi, Dongwon|Kim, Nam Yoon|Yang, Sara|Jung, Eunson|Hong, Mingu|Yang, Dongyun|Lenz, Heinz-Josef|Hong, Young-Kwon
PMID: 24338666
Journal: Mucosal Immunol. 2014 Sep;7(5):1079-93.
Title: IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice.
Author: Guabiraba, R|Besnard, A G|Menezes, G B|Secher, T|Jabir, M S|Amaral, S S|Braun, H|Lima-Junior, R C P|Ribeiro, R A|Cunha, F Q|Teixeira, M M|Beyaert, R|Graham, G J|Liew, F Y
PMID: 24424522
Journal: BMC Cancer. 2014 Aug 18;14:599.
Title: Variable NF-kappaB pathway responses in colon cancer cells treated with chemotherapeutic drugs.
Author: Samuel, Temesgen|Fadlalla, Khalda|Gales, Dominique N|Putcha, Balananda D K|Manne, Upender
PMID: 25134433
Journal: Cancer Lett. 2014 Nov 28;354(2):245-53.
Title: Interleukin-8 promotes cell migration through integrin alphavbeta6 upregulation in colorectal cancer.
Author: Sun, Qi|Sun, Fengkai|Wang, Ben|Liu, Song|Niu, Weibo|Liu, Enyu|Peng, Cheng|Wang, Jiayong|Gao, Huijie|Liang, Benjia|Niu, Zhengchuan|Zou, Xueqing|Niu, Jun
PMID: 25150782
Journal: Int J Biol Sci. 2014 Aug 24;10(9):948-56.
Title: Extraintestinal helminth infection reduces the development of colitis-associated tumorigenesis.
Author: Leon-Cabrera, Sonia|Callejas, Blanca E|Ledesma-Soto, Yadira|Coronel, Jossimar|Perez-Plasencia, Carlos|Gutierrez-Cirlos, Emma B|Avila-Moreno, Federico|Rodriguez-Sosa, Miriam|Hernandez-Pando, Rogelio|Marquina-Castillo, Brenda|Chirino, Yolanda I|Terrazas, Lu
PMID: 25210492
Journal: PLoS One. 2014 Dec 26;9(12):e116169.
Title: The influence of the CHIEF pathway on colorectal cancer-specific mortality.
Author: Slattery, Martha L|Lundgreen, Abbie
PMID: 25541970
Journal: J Chem Inf Model. 2015 Aug 24;55(8):1720-38.
Title: Discovery of Novel CXCR2 Inhibitors Using Ligand-Based Pharmacophore Models.
Author: Ha, Helen|Debnath, Bikash|Odde, Srinivas|Bensman, Tim|Ho, Henry|Beringer, Paul M|Neamati, Nouri
PMID: 26153616
Journal: Med Oncol. 2015 Dec;32(12):258.
Title: The role of interleukin-8 (CXCL8) and CXCR2 in acquired chemoresistance of human colorectal carcinoma cells HCT116.
Author: Dabkeviciene, Daiva|Jonusiene, Violeta|Zitkute, Vilmante|Zalyte, Egle|Grigaitis, Pranas|Kirveliene, Vida|Sasnauskiene, Ausra
PMID: 26519257
Journal: Oncotarget. 2015 Oct 6;6(30):28800-15.
Title: Primary tumor- and metastasis-derived colon cancer cells differently modulate connexin expression and function in human capillary endothelial cells.
Author: Thuringer, Dominique|Berthenet, Kevin|Cronier, Laurent|Solary, Eric|Garrido, Carmen
PMID: 26320187
Journal: Int J Clin Exp Med. 2015 Apr 15;8(4):5883-9. eCollection 2015.
Title: Expression of CXCR2 and its clinical significance in human colorectal cancer.
Author: Wu, Wenjuan|Sun, Changjiang|Xu, Daoliang|Zhang, Xizhi|Shen, Weigan|Lv, Ye|Ma, Tao
PMID: 26131180
Journal: Carcinogenesis. 2015 Sep;36(9):999-1007.
Title: Identification of a common variant with potential pleiotropic effect on risk of inflammatory bowel disease and colorectal cancer.
Author: Khalili, Hamed|Gong, Jian|Brenner, Hermann|Austin, Thomas R|Hutter, Carolyn M|Baba, Yoshifumi|Baron, John A|Berndt, Sonja I|Bezieau, Stephane|Caan, Bette|Campbell, Peter T|Chang-Claude, Jenny|Chanock, Stephen J|Chen, Constance|Hsu, Li|Jiao, Shuo|Conti, Da
PMID: 26071399
Journal: Clin Cancer Res. 2015 Apr 1;21(7):1583-90.
Title: Pharmacogenetic Analysis of INT 0144 Trial: Association of Polymorphisms with Survival and Toxicity in Rectal Cancer Patients Treated with 5-FU and Radiation.
Author: Bohanes, Pierre|Rankin, Cathryn J|Blanke, Charles D|Winder, Thomas|Ulrich, Cornelia M|Smalley, Stephen R|Rich, Tyvin A|Martensen, James A|Benson, Al B 3rd|Mayer, Robert J|Cripps, Christine M|Danenberg, Kathleen|Makar, Karen W|Zhang, Wu|Benedetti, Jacqueli
PMID: 25589620
Journal: Cancer Sci. 2015 Mar;106(3):262-9.
Title: Overexpression of chemokine receptor CXCR2 and ligand CXCL7 in liver metastases from colon cancer is correlated to shorter disease-free and overall survival.
Author: Desurmont, Thibault|Skrypek, Nicolas|Duhamel, Alain|Jonckheere, Nicolas|Millet, Guillaume|Leteurtre, Emmanuelle|Gosset, Pierre|Duchene, Belinda|Ramdane, Nassima|Hebbar, Mohamed|Van Seuningen, Isabelle|Pruvot, Francois-Rene|Huet, Guillemette|Truant, Stepha
PMID: 25580640
Journal: Lasers Surg Med. 2015 Jan;47(1):40-9.
Title: In vivo molecular mapping of the tumor microenvironment in an azoxymethane-treated mouse model of colon carcinogenesis.
Author: Leung, Sarah J|Rice, Photini S|Barton, Jennifer K
PMID: 25487746
Journal: Cytokine Growth Factor Rev. 2016 Oct;31:61-71.
Title: The CXCL8-CXCR1/2 pathways in cancer.
Author: Liu, Qian|Li, Anping|Tian, Yijun|Wu, Jennifer D|Liu, Yu|Li, Tengfei|Chen, Yuan|Han, Xinwei|Wu, Kongming
PMID: 27578214
Journal: Mol Cell Biol. 2017 Feb 15;37(5). pii: MCB.00481-16.
Title: Epithelial Hypoxia-Inducible Factor 2alpha Facilitates the Progression of Colon Tumors through Recruiting Neutrophils.
Author: Triner, Daniel|Xue, Xiang|Schwartz, Andrew J|Jung, Inkyung|Colacino, Justin A|Shah, Yatrik M
PMID: 27956697
Journal: Mol Cancer. 2017 Mar 29;16(1):70.
Title: Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3beta/beta-catenin pathways.
Author: Zhao, Jingkun|Ou, Baochi|Han, Dingpei|Wang, Puxiongzhi|Zong, Yaping|Zhu, Congcong|Liu, Di|Zheng, Minhua|Sun, Jing|Feng, Hao|Lu, Aiguo
PMID: 28356111
Journal: Cancer Immunol Res. 2017 May;5(5):385-396.
Title: Lack of STAT6 Attenuates Inflammation and Drives Protection against Early Steps of Colitis-Associated Colon Cancer.
Author: Leon-Cabrera, Sonia A|Molina-Guzman, Emmanuel|Delgado-Ramirez, Yael G|Vazquez-Sandoval, Armando|Ledesma-Soto, Yadira|Perez-Plasencia, Carlos G|Chirino, Yolanda I|Delgado-Buenrostro, Norma L|Rodriguez-Sosa, Miriam|Vaca-Paniagua, Felipe|Avila-Moreno, Federi
PMID: 28385737
Journal: Oncotarget. 2017 Apr 25;8(17):28442-28454.
Title: Overexpression of CXCR2 predicts poor prognosis in patients with colorectal cancer.
Author: Zhao, Jingkun|Ou, Baochi|Feng, Hao|Wang, Puxiongzhi|Yin, Shuai|Zhu, Congcong|Wang, Shenjie|Chen, Chun|Zheng, Minhua|Zong, Yaping|Sun, Jing|Lu, Aiguo
PMID: 28415702
Journal: Cancer Res. 2017 Jul 1;77(13):3655-3665.
Title: CXCL1 Is Critical for Premetastatic Niche Formation and Metastasis in Colorectal Cancer.
Author: Wang, Dingzhi|Sun, Haiyan|Wei, Jie|Cen, Bo|DuBois, Raymond N
PMID: 28455419
Journal: Biosens Bioelectron. 2018 Feb 15;100:396-403.
Title: Development of a bifunctional nanobiosensor for screening and detection of chemokine ligand in colorectal cancer cell line.
Author: Chung, Saeromi|Chandra, Pranjal|Koo, Jaseok Peter|Shim, Yoon-Bo
PMID: 28954256
Journal: Eur J Immunol. 2018 Mar;48(3):532-542.
Title: Tumor conditions induce bone marrow expansion of granulocytic, but not monocytic, immunosuppressive leukocytes with increased CXCR2 expression in mice.
Author: Bian, Zhen|Shi, Lei|Venkataramani, Mahathi|Abdelaal, Ahmed Mansour|Culpepper, Courtney|Kidder, Koby|Liang, Hongwei|Zen, Ke|Liu, Yuan
PMID: 29120053
Journal: Cell Host Microbe. 2018 Feb 14;23(2):203-214.e5.
Title: Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells.
Author: Chung, Liam|Thiele Orberg, Erik|Geis, Abby L|Chan, June L|Fu, Kai|DeStefano Shields, Christina E|Dejea, Christine M|Fathi, Payam|Chen, Jie|Finard, Benjamin B|Tam, Ada J|McAllister, Florencia|Fan, Hongni|Wu, Xinqun|Ganguly, Sudipto|Lebid, Andriana|Metz, Pa
PMID: 29398651
Journal: Mol Cancer Ther. 2018 May;17(5):977-987.
Title: A miR-29b Byproduct Sequence Exhibits Potent Tumor-Suppressive Activities via Inhibition of NF-kappaB Signaling in KRAS-Mutant Colon Cancer Cells.
Author: Inoue, Akira|Mizushima, Tsunekazu|Wu, Xin|Okuzaki, Daisuke|Kambara, Nanami|Ishikawa, Sho|Wang, Jiaqi|Qian, Yamin|Hirose, Haruka|Yokoyama, Yuhki|Ikeshima, Ryo|Hiraki, Masayuki|Miyoshi, Norikatsu|Takahashi, Hidekazu|Haraguchi, Naotsugu|Hata, Taishi|Matsuda,
PMID: 29545333