Primary Site >> Colorectal Cancer
Gene >> CXCR2
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Ref: Expression of interleukin 8 and its receptors in human colon carcinoma cells with different metastatic potentials. PMID: 11595728 |
Ref: The epithelial-mesenchymal transition of colon carcinoma involves expression of IL-8 and CXCR-1-mediated chemotaxis. PMID: 15350531 Ref: Constitutive expression of growth regulated oncogene (gro) in human colon carcinoma cells with different metastatic potential and its role in regulating their metastatic phenotype. PMID: 15787094 |
Ref: Dendritic cells delivered inside human carcinomas are sequestered by interleukin-8. PMID: 15800914 Ref: Gene polymorphisms of epidermal growth factor receptor and its downstream effector, interleukin-8, predict oxaliplatin efficacy in patients with advanced colorectal cancer. PMID: 16098254 |
Ref: Macrophage inflammatory protein-2 promotes angiogenesis, cell migration, and tumor growth in hepatic metastasis. PMID: 16424980 Ref: GROalpha is highly expressed in adenocarcinoma of the colon and down-regulates fibulin-1. PMID: 17062666 |
Ref: Studies on MIP-2 and CXCR2 expression in a mouse model of extrahepatic colorectal metastasis. PMID: 17314027 |
Ref: Liver resection-associated macrophage inflammatory protein-2 stimulates engraftment but not growth of colorectal metastasis at extrahepatic sites. PMID: 17561115 Ref: ELR+ CXC chemokine expression in benign and malignant colorectal conditions. PMID: 18578857 Ref: TSU68 prevents liver metastasis of colon cancer xenografts by modulating the premetastatic niche. PMID: 19047154 Ref: Individualization of therapy for colorectal cancer based on clinical and molecular parameters. PMID: 19343148 |
Ref: Expression of chemokines and chemokine receptors in human colon cancer. PMID: 19446722 |
Ref: GROalpha promotes invasion of colorectal cancer cells. PMID: 21042742 |
Ref: Small molecule antagonists for CXCR2 and CXCR1 inhibit human colon cancer liver metastases. PMID: 21035946 Ref: The expression and prognostic impact of CXC-chemokines in stage II and III colorectal cancer epithelial and stromal tissue. PMID: 21285972 Ref: Carcinoma-derived interleukin-8 disorients dendritic cell migration without impairing T-cell stimulation. PMID: 21423807 |
Ref: Neutrophil transintestinal epithelial migration to CXCR2 ligands is regulated by adenosine. PMID: 21857250 Ref: CXCL5, a promoter of cell proliferation, migration and invasion, is a novel serum prognostic marker in patients with colorectal cancer. PMID: 22197219 Ref: High expression of CXCR2 is associated with tumorigenesis, progression, and prognosis of laryngeal squamous cell carcinoma. PMID: 22274915 Ref: The CXCR2 antagonist, SCH-527123, shows antitumor activity and sensitizes cells to oxaliplatin in preclinical colon cancer models. PMID: 22391039 Ref: Targeting IL-8 in colorectal cancer. PMID: 22494524 Ref: Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis. PMID: 22617157 Ref: Volatile anesthetics reduce invasion of colorectal cancer cells through down-regulation of matrix metalloproteinase-9. PMID: 22739763 Ref: Crucial involvement of tumor-associated neutrophils in the regulation of chronic colitis-associated carcinogenesis in mice. PMID: 23272179 |
Ref: Interleukin genes and associations with colon and rectal cancer risk and overall survival. PMID: 22674296 Ref: Mice that express human interleukin-8 have increased mobilization of immature myeloid cells, which exacerbates inflammation and accelerates colon carcinogenesis. PMID: 23041326 Ref: The expression of chemokine receptors CCR6, CXCR2 and CXCR4 is not organ-specific for distant metastasis in colorectal cancer: a comparative study. PMID: 23758411 Ref: Single cells from human primary colorectal tumors exhibit polyfunctional heterogeneity in secretions of ELR+ CXC chemokines. PMID: 23995780 |
Ref: CXCR2 inhibition enhances sulindac-mediated suppression of colon cancer development. PMID: 24338666 Ref: IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice. PMID: 24424522 Ref: Variable NF-kappaB pathway responses in colon cancer cells treated with chemotherapeutic drugs. PMID: 25134433 Ref: Interleukin-8 promotes cell migration through integrin alphavbeta6 upregulation in colorectal cancer. PMID: 25150782 Ref: Extraintestinal helminth infection reduces the development of colitis-associated tumorigenesis. PMID: 25210492 Ref: The influence of the CHIEF pathway on colorectal cancer-specific mortality. PMID: 25541970 |
Ref: In vivo molecular mapping of the tumor microenvironment in an azoxymethane-treated mouse model of colon carcinogenesis. PMID: 25487746 Ref: Overexpression of chemokine receptor CXCR2 and ligand CXCL7 in liver metastases from colon cancer is correlated to shorter disease-free and overall survival. PMID: 25580640 Ref: Pharmacogenetic Analysis of INT 0144 Trial: Association of Polymorphisms with Survival and Toxicity in Rectal Cancer Patients Treated with 5-FU and Radiation. PMID: 25589620 Ref: Identification of a common variant with potential pleiotropic effect on risk of inflammatory bowel disease and colorectal cancer. PMID: 26071399 Ref: Expression of CXCR2 and its clinical significance in human colorectal cancer. PMID: 26131180 Ref: Discovery of Novel CXCR2 Inhibitors Using Ligand-Based Pharmacophore Models. PMID: 26153616 Ref: Primary tumor- and metastasis-derived colon cancer cells differently modulate connexin expression and function in human capillary endothelial cells. PMID: 26320187 Ref: The role of interleukin-8 (CXCL8) and CXCR2 in acquired chemoresistance of human colorectal carcinoma cells HCT116. PMID: 26519257 |
Ref: The CXCL8-CXCR1/2 pathways in cancer. PMID: 27578214 |
Ref: Epithelial Hypoxia-Inducible Factor 2alpha Facilitates the Progression of Colon Tumors through Recruiting Neutrophils. PMID: 27956697 Ref: Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3beta/beta-catenin pathways. PMID: 28356111 Ref: Lack of STAT6 Attenuates Inflammation and Drives Protection against Early Steps of Colitis-Associated Colon Cancer. PMID: 28385737 Ref: Overexpression of CXCR2 predicts poor prognosis in patients with colorectal cancer. PMID: 28415702 Ref: CXCL1 Is Critical for Premetastatic Niche Formation and Metastasis in Colorectal Cancer. PMID: 28455419 |
Ref: Development of a bifunctional nanobiosensor for screening and detection of chemokine ligand in colorectal cancer cell line. PMID: 28954256 Ref: Tumor conditions induce bone marrow expansion of granulocytic, but not monocytic, immunosuppressive leukocytes with increased CXCR2 expression in mice. PMID: 29120053 Ref: Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells. PMID: 29398651 Ref: A miR-29b Byproduct Sequence Exhibits Potent Tumor-Suppressive Activities via Inhibition of NF-kappaB Signaling in KRAS-Mutant Colon Cancer Cells. PMID: 29545333 |