Primary Site >> Liver Cancer

Gene >> CXCL12

Journal: Exp Cell Res. 1994 Dec;215(2):284-93.
Title: Molecular cloning of TPAR1, a gene whose expression is repressed by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA).
Author: Jiang, W|Zhou, P|Kahn, S M|Tomita, N|Johnson, M D|Weinstein, I B
PMID: 7982471
Journal: Int J Cancer. 1997 Nov 27;73(5):656-62.
Title: Reduced expression of the CXC chemokine hIRH/SDF-1alpha mRNA in hepatoma and digestive tract cancer.
Author: Shibuta, K|Begum, N A|Mori, M|Shimoda, K|Akiyoshi, T|Barnard, G F
PMID: 9398042
Journal: Int J Oncol. 1999 May;14(5):917-25.
Title: CXCR4 mRNA expression in colon, esophageal and gastric cancers and hepatitis C infected liver.
Author: Mitra, P|Shibuta, K|Mathai, J|Shimoda, K|Banner, B F|Mori, M|Barnard, G F
PMID: 10200342
Journal: Int J Oncol. 1999 May;14(5):927-34.
Title: Reduced expression of the CXCR4 receptor mRNA in hepatocellular carcinoma and lack of inducibility of its ligand alpha-chemokine hIRH/SDF1alpha/PBSF in vitro.
Author: Begum, N A|Shibuta, K|Mori, M|Barnard, G F
PMID: 10200343
Journal: Jpn J Cancer Res. 2002 Jul;93(7):789-97.
Title: Regional expression of CXCL12/CXCR4 in liver and hepatocellular carcinoma and cell-cycle variation during in vitro differentiation.
Author: Shibuta, Kenji|Mori, Masaki|Shimoda, Katsuhiro|Inoue, Hiroshi|Mitra, Prasenjit|Barnard, Graham F
PMID: 12149145
Journal: Ann Pathol. 2005 Feb;25(1):33-44.
Title: [Which stem cells for adult liver?].
Author: Guettier, Catherine
PMID: 15981930
Journal: Biochem Biophys Res Commun. 2006 Feb 17;340(3):758-66.
Title: Elevated expression and potential roles of human Sp5, a member of Sp transcription factor family, in human cancers.
Author: Chen, Yongxin|Guo, Yingqiu|Ge, Xijin|Itoh, Hirotaka|Watanabe, Akira|Fujiwara, Takeshi|Kodama, Tatsuhiko|Aburatani, Hiroyuki
PMID: 16380080
Journal: J Cancer Res Clin Oncol. 2006 Jul;132(7):473-81.
Title: Involvement of c-myc-regulated genes in hepatocellular carcinoma related to genotype-C hepatitis B virus.
Author: Iizuka, Norio|Tsunedomi, Ryouichi|Tamesa, Takao|Okada, Toshimasa|Sakamoto, Kazuhiko|Hamaguchi, Takashi|Yamada-Okabe, Hisafumi|Miyamoto, Takanobu|Uchimura, Shunji|Hamamoto, Yoshihiko|Oka, Masaaki
PMID: 16703398
Journal: Scand J Immunol. 2006 Jun;63(6):468-77.
Title: Enhanced expression and clinical significance of CC-chemokine MIP-3 alpha in hepatocellular carcinoma.
Author: Rubie, C|Frick, V O|Wagner, M|Rau, B|Weber, C|Kruse, B|Kempf, K|Tilton, B|Konig, J|Schilling, M
PMID: 16764701
Journal: Ann Surg. 2006 Jul;244(1):113-20.
Title: Chemokine receptor CXCR4 expression in patients with melanoma and colorectal cancer liver metastases and the association with disease outcome.
Author: Kim, Joseph|Mori, Takuji|Chen, Steven L|Amersi, Farin F|Martinez, Steve R|Kuo, Christine|Turner, Roderick R|Ye, Xing|Bilchik, Anton J|Morton, Donald L|Hoon, Dave S B
PMID: 16794396
Journal: Br J Cancer. 2006 Jul 17;95(2):210-7.
Title: Dissemination of hepatocellular carcinoma is mediated via chemokine receptor CXCR4.
Author: Schimanski, C C|Bahre, R|Gockel, I|Muller, A|Frerichs, K|Horner, V|Teufel, A|Simiantonaki, N|Biesterfeld, S|Wehler, T|Schuler, M|Achenbach, T|Junginger, T|Galle, P R|Moehler, M
PMID: 16819541
Journal: World J Gastroenterol. 2006 Nov 7;12(41):6627-33.
Title: Chemokine expression in hepatocellular carcinoma versus colorectal liver metastases.
Author: Rubie, Claudia|Frick, Vilma Oliveira|Wagner, Mathias|Weber, Christina|Kruse, Bianca|Kempf, Katja|Konig, Jochen|Rau, Bettina|Schilling, Martin
PMID: 17075975
Journal: Eur J Gastroenterol Hepatol. 2007 May;19(5):425-31.
Title: Lack of association of some chemokine system polymorphisms with the risks of death and hepatocellular carcinoma occurrence in patients with alcoholic cirrhosis: a prospective study.
Author: Nahon, Pierre|Sutton, Angela|Rufat, Pierre|Faisant, Charles|Simon, Chantal|Barget, Nathalie|Trinchet, Jean-Claude|Beaugrand, Michel|Gattegno, Liliane|Charnaux, Nathalie
PMID: 17413295
Journal: Oncol Rep. 2007 Jun;17(6):1541-9.
Title: Genome wide expression profiling identifies genes associated with colorectal liver metastasis.
Author: Lin, H-M|Chatterjee, A|Lin, Y-H|Anjomshoaa, A|Fukuzawa, R|McCall, J L|Reeve, A E
PMID: 17487416
Journal: World J Gastroenterol. 2008 Feb 7;14(5):713-9.
Title: Chemokine system polymorphisms, survival and hepatocellular carcinoma occurrence in patients with hepatitis C virus-related cirrhosis.
Author: Nahon, Pierre|Sutton, Angela|Rufat, Pierre|Simon, Chantal|Trinchet, Jean-Claude|Gattegno, Liliane|Beaugrand, Michel|Charnaux, Nathalie
PMID: 18205260
Journal: Anat Sci Int. 2009 Sep;84(3):226-36.
Title: Role of the CXCL12/CXCR4 axis in milky spots of rats bearing ascitic-type hepatoma.
Author: Abe, Hirokazu|Ina, Keisuke|Kitamura, Hirokazu|Sumiyoshi, Hideaki|Tatsukawa, Shuji|Yoshioka, Hidekatsu|Fujikura, Yoshihisa
PMID: 19340530
Journal: J Exp Clin Cancer Res. 2010 Apr 11;29:31.
Title: Chemokine receptor CXCR7 regulates the invasion, angiogenesis and tumor growth of human hepatocellular carcinoma cells.
Author: Zheng, Ke|Li, Hong-Yuan|Su, Xin-Liang|Wang, Xiao-Yi|Tian, Tian|Li, Fan|Ren, Guo-Sheng
PMID: 20380740
Journal: World J Gastroenterol. 2010 Apr 21;16(15):1832-6.
Title: Chemokines and hepatocellular carcinoma.
Author: Huang, Fan|Geng, Xiao-Ping
PMID: 20397259
Journal: Biochem Pharmacol. 2010 Nov 15;80(10):1553-62.
Title: Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-kappaB activation in breast and pancreatic tumor cells.
Author: Chua, Angeline Wei Ling|Hay, Hui Sin|Rajendran, Peramaiyan|Shanmugam, Muthu K|Li, Feng|Bist, Pradeep|Koay, Evelyn S C|Lim, Lina H K|Kumar, Alan Prem|Sethi, Gautam
PMID: 20699088
Journal: Clin Cancer Res. 2011 Apr 15;17(8):2074-80.
Title: CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies?
Author: Duda, Dan G|Kozin, Sergey V|Kirkpatrick, Nathaniel D|Xu, Lei|Fukumura, Dai|Jain, Rakesh K
PMID: 21349998
Journal: Ann Surg Oncol. 2012 Jul;19 Suppl 3:S339-46.
Title: CXCR4 expression predicts patient outcome and recurrence patterns after hepatic resection for colorectal liver metastases.
Author: Yopp, Adam C|Shia, Jinru|Butte, Jean M|Allen, Peter J|Fong, Yuman|Jarnagin, William R|DeMatteo, Ronald P|D'Angelica, Michael I
PMID: 21584832
Journal: Clin Exp Metastasis. 2012 Feb;29(2):101-10.
Title: CXCR4/CXCL12 expression profile is associated with tumor microenvironment and clinical outcome of liver metastases of colorectal cancer.
Author: Sakai, Nozomu|Yoshidome, Hiroyuki|Shida, Takashi|Kimura, Fumio|Shimizu, Hiroaki|Ohtsuka, Masayuki|Takeuchi, Dan|Sakakibara, Masahiro|Miyazaki, Masaru
PMID: 22075627
Journal: Chin Med J (Engl). 2012 Mar;125(5):786-93.
Title: Inhibiting effect of Astragalus polysaccharides on the functions of CD4+CD25 highTreg cells in the tumor microenvironment of human hepatocellular carcinoma.
Author: Li, Qiang|Bao, Jian-min|Li, Xiao-li|Zhang, Ti|Shen, Xiao-hong
PMID: 22490576
Journal: PLoS One. 2013;8(3):e57015.
Title: Emodin suppresses migration and invasion through the modulation of CXCR4 expression in an orthotopic model of human hepatocellular carcinoma.
Author: Manu, Kanjoormana Aryan|Shanmugam, Muthu K|Ong, Tina H|Subramaniam, Aruljothi|Siveen, Kodappully Sivaraman|Perumal, Ekambaram|Samy, Ramar Perumal|Bist, Pradeep|Lim, Lina H K|Kumar, Alan Prem|Hui, Kam M|Sethi, Gautam
PMID: 23472074
Journal: Hepatology. 2013 Dec;58(6):2032-44.
Title: Overactivation of the TGF-beta pathway confers a mesenchymal-like phenotype and CXCR4-dependent migratory properties to liver tumor cells.
Author: Bertran, Esther|Crosas-Molist, Eva|Sancho, Patricia|Caja, Laia|Lopez-Luque, Judit|Navarro, Estanislao|Egea, Gustavo|Lastra, Raquel|Serrano, Teresa|Ramos, Emilio|Fabregat, Isabel
PMID: 23813475
Journal: Acta Pharmacol Sin. 2013 Dec;34(12):1554-9.
Title: Oligomannurarate sulfate inhibits CXCL12/SDF-1-mediated proliferation and invasion of human tumor cells in vitro.
Author: Wen, Wei-wei|Xie, Shao|Xin, Xian-liang|Geng, Mei-yu|Ding, Jian|Chen, Yi
PMID: 24141568
Journal: Cell Death Dis. 2014 Oct 23;5:e1488.
Title: CXCR7 stimulates MAPK signaling to regulate hepatocellular carcinoma progression.
Author: Lin, L|Han, M-M|Wang, F|Xu, L-L|Yu, H-X|Yang, P-Y
PMID: 25341042
Journal: PLoS One. 2014 Jun 18;9(6):e100372.
Title: AEG-1 promotes anoikis resistance and orientation chemotaxis in hepatocellular carcinoma cells.
Author: Zhou, Zhenzhen|Deng, Huan|Yan, Wei|Luo, Min|Tu, Wei|Xia, Yujia|He, Jiayi|Han, Ping|Fu, Yu|Tian, De'an
PMID: 24941119
Journal: J Biol Chem. 2014 Nov 14;289(46):31879-90.
Title: Novel synthetic biscoumarins target tumor necrosis factor-alpha in hepatocellular carcinoma in vitro and in vivo.
Author: Keerthy, Hosadurga Kumar|Mohan, Chakrabhavi Dhananjaya|Sivaraman Siveen, Kodappully|Fuchs, Julian E|Rangappa, Shobith|Sundaram, Mahalingam S|Li, Feng|Girish, Kesturu S|Sethi, Gautam|Basappa|Bender, Andreas|Rangappa, Kanchugarakoppal Subbegowda
PMID: 25231984
Journal: PLoS One. 2014 Mar 10;9(3):e88543.
Title: Dynamic expression patterns of differential proteins during early invasion of hepatocellular carcinoma.
Author: Chen, Rong-Xin|Song, Hai-Yan|Dong, Yin-Ying|Hu, Chao|Zheng, Qiong-Dan|Xue, Tong-Chun|Liu, Xiao-Hui|Zhang, Yang|Chen, Jie|Ren, Zheng-Gang|Liu, Yin-Kun|Cui, Jie-Feng
PMID: 24614035
Journal: Am J Transl Res. 2014 Jul 18;6(4):340-52. eCollection 2014.
Title: Insights on the CXCL12-CXCR4 axis in hepatocellular carcinoma carcinogenesis.
Author: Ghanem, Ismael|Riveiro, Maria E|Paradis, Valerie|Faivre, Sandrine|de Parga, Paula M Vazquez|Raymond, Eric
PMID: 25075251
Journal: Cell Mol Immunol. 2015 Jul;12(4):474-82.
Title: CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not.
Author: Neve Polimeno, Maria|Ierano, Caterina|D'Alterio, Crescenzo|Simona Losito, Nunzia|Napolitano, Maria|Portella, Luigi|Scognamiglio, Giosue|Tatangelo, Fabiana|Maria Trotta, Anna|Curley, Steven|Costantini, Susan|Liuzzi, Raffaele|Izzo, Francesco|Scala, Stefania
PMID: 25363530
Journal: Bioorg Med Chem Lett. 2015 Feb 15;25(4):893-7.
Title: Novel synthetic coumarins that targets NF-kappaB in Hepatocellular carcinoma.
Author: Neelgundmath, Mahabaleshwaraiah|Dinesh, Koragere Rajashekar|Mohan, Chakrabhavi Dhananjaya|Li, Feng|Dai, Xiaoyun|Siveen, Kodappully Sivaraman|Paricharak, Shardul|Mason, Daniel J|Fuchs, Julian E|Sethi, Gautam|Bender, Andreas|Rangappa, Kanchugarakoppal S|Kot
PMID: 25592709
Journal: Glycobiology. 2015 Aug;25(8):825-35.
Title: 4-methylumbelliferone inhibits hepatocellular carcinoma growth by decreasing IL-6 production and angiogenesis.
Author: Piccioni, Flavia|Fiore, Esteban|Bayo, Juan|Atorrasagasti, Catalina|Peixoto, Estanislao|Rizzo, Manglio|Malvicini, Mariana|Tirado-Gonzalez, Irene|Garcia, Mariana G|Alaniz, Laura|Mazzolini, Guillermo
PMID: 25882295
Journal: Oncotarget. 2015 May 20;6(14):12061-79.
Title: TIMP-1 activated carcinoma-associated fibroblasts inhibit tumor apoptosis by activating SDF1/CXCR4 signaling in hepatocellular carcinoma.
Author: Song, Tao|Dou, Changwei|Jia, Yuli|Tu, Kangsheng|Zheng, Xin
PMID: 25909286
Journal: Oncoimmunology. 2016 Nov 29;5(12):e1254313.
Title: CXCR4-CXCL12-CXCR7, TLR2-TLR4, and PD-1/PD-L1 in colorectal cancer liver metastases from neoadjuvant-treated patients.
Author: D'Alterio, Crescenzo|Nasti, Guglielmo|Polimeno, Marianeve|Ottaiano, Alessandro|Conson, Manuel|Circelli, Luisa|Botti, Giovanni|Scognamiglio, Giosue|Santagata, Sara|De Divitiis, Chiara|Nappi, Anna|Napolitano, Maria|Tatangelo, Fabiana|Pacelli, Roberto|Izzo,
PMID: 28123896
Journal: Cell Mol Biol (Noisy-le-grand). 2016 Sep 30;62(11):81-86.
Title: Trafficking mechanism of bone marrow-derived mesenchymal stem cells toward hepatocellular carcinoma HepG2 cells by modulating Endoglin, CXCR4 and TGF-beta.
Author: Mardomi, A|Sabzichi, M|Hussein Somi, M|Shanehbandi, D|Rahbarghazi, R|Taj Sanjarani, O|Samadi, N
PMID: 27755957
Journal: Cancer Lett. 2016 Dec 1;383(1):18-27.
Title: Vascular mimicry formation is promoted by paracrine TGF-beta and SDF1 of cancer-associated fibroblasts and inhibited by miR-101 in hepatocellular carcinoma.
Author: Yang, Jine|Lu, Yang|Lin, Ying-Ying|Zheng, Zhi-Yuan|Fang, Jian-Hong|He, Shuai|Zhuang, Shi-Mei
PMID: 27693460
Journal: Oncol Rep. 2016 Oct;36(4):2184-92.
Title: Clinical effects of miR-101 on prognosis of hepatocellular carcinoma and carcinogenic mechanism of anti-miR-101.
Author: Lv, Xuecheng|Li, Jinghua|Yang, Bingnan
PMID: 27498785
Journal: Am J Physiol Gastrointest Liver Physiol. 2016 Aug 1;311(2):G203-9.
Title: Stromal cell-derived factor-1 (SDF-1) as a target in liver diseases.
Author: Liepelt, Anke|Tacke, Frank
PMID: 27313175
Journal: Oncogene. 2016 Dec 1;35(48):6212-6222.
Title: Activation of the SDF1/CXCR4 pathway retards muscle atrophy during cancer cachexia.
Author: Martinelli, G B|Olivari, D|Re Cecconi, A D|Talamini, L|Ottoboni, L|Lecker, S H|Stretch, C|Baracos, V E|Bathe, O F|Resovi, A|Giavazzi, R|Cervo, L|Piccirillo, R
PMID: 27212031
Journal: Int Immunopharmacol. 2016 Jul;36:100-105.
Title: Preparation and characterization of a new monoclonal antibody against CXCR4 using lentivirus vector.
Author: Li, Xinyi|Kuang, Yu|Huang, Xiaojun|Zou, Linlin|Huang, Liuye|Yang, Ting|Li, Wanyi|Yang, Yuan
PMID: 27124560
Journal: Virchows Arch. 2017 Feb;470(2):185-196.
Title: CXCL12 expression and PD-L1 expression serve as prognostic biomarkers in HCC and are induced by hypoxia.
Author: Semaan, Alexander|Dietrich, Dimo|Bergheim, Dominik|Dietrich, Jorn|Kalff, Jorg C|Branchi, Vittorio|Matthaei, Hanno|Kristiansen, Glen|Fischer, Hans-Peter|Goltz, Diane
PMID: 27913861
Journal: Cell Death Dis. 2017 Jan 19;8(1):e2560.
Title: Hepatitis B virus X protein promotes the stem-like properties of OV6(+) cancer cells in hepatocellular carcinoma.
Author: Wang, Chao|Wang, Ming-da|Cheng, Peng|Huang, Hai|Dong, Wei|Zhang, Wei-Wei|Li, Peng-Peng|Lin, Chuan|Pan, Ze-Ya|Wu, Meng-Chao|Zhou, Wei-Ping
PMID: 28102846
Journal: World J Surg Oncol. 2017 Mar 16;15(1):63.
Title: Identification and interaction analysis of key genes and microRNAs in hepatocellular carcinoma by bioinformatics analysis.
Author: Mou, Tong|Zhu, Di|Wei, Xufu|Li, Tingting|Zheng, Daofeng|Pu, Junliang|Guo, Zhen|Wu, Zhongjun
PMID: 28302149
Journal: World J Gastroenterol. 2017 May 7;23(17):3053-3065.
Title: CXCR7/CXCL12 axis is involved in lymph node and liver metastasis of gastric carcinoma.
Author: Xin, Qi|Zhang, Na|Yu, Hai-Bo|Zhang, Qin|Cui, Yan-Fen|Zhang, Chuan-Shan|Ma, Zhe|Yang, Yan|Liu, Wei
PMID: 28533662
Journal: Organogenesis. 2017 Jul 3;13(3):83-94.
Title: Microenvironment of a tumor-organoid system enhances hepatocellular carcinoma malignancy-related hallmarks.
Author: Wang, Yang|Takeishi, Kazuki|Li, Zhao|Cervantes-Alvarez, Eduardo|Collin de l'Hortet, Alexandra|Guzman-Lepe, Jorge|Cui, Xiao|Zhu, Jiye
PMID: 28548903
Journal: Oncol Lett. 2017 Aug;14(2):1905-1910.
Title: Role of C-X-C chemokine ligand 12/C-X-C chemokine receptor 4 in the progression of hepatocellular carcinoma.
Author: Jeng, Kuo-Shyang|Jeng, Chi-Juei|Jeng, Wen-Juei|Chang, Chiung-Fang|Sheen, I-Shyan
PMID: 28789425
Journal: BMC Cancer. 2017 Dec 19;17(1):870.
Title: Serum cytokine profiles predict survival benefits in patients with advanced hepatocellular carcinoma treated with sorafenib: a retrospective cohort study.
Author: Hayashi, Tomoyuki|Yamashita, Taro|Terashima, Takeshi|Suda, Tsuyoshi|Okada, Hikari|Asahina, Yoshiro|Hayashi, Takehiro|Hara, Yasumasa|Nio, Kouki|Sunagozaka, Hajime|Takatori, Hajime|Arai, Kuniaki|Sakai, Yoshio|Yamashita, Tatsuya|Mizukoshi, Eishiro|Honda, Mas
PMID: 29258450
Journal: Oncotarget. 2017 Nov 20;9(15):12471-12478.
Title: Research progress on the forkhead box C1.
Author: Wang, Jinhua|Li, Wan|Zheng, Xiangjin|Pang, Xiaocong|Du, Guanhua
PMID: 29552326
Journal: Hum Gene Ther. 2018 May 3.
Title: External Beam Radiation Therapy Enhances Mesenchymal Stem Cell-Mediated Sodium-Iodide Symporter Gene Delivery.
Author: Schug, Christina|Sievert, Wolfgang|Urnauer, Sarah|Muller, Andrea M|Schmohl, Kathrin A|Wechselberger, Alexandra|Schwenk, Nathalie|Lauber, Kirsten|Schwaiger, Markus|Multhoff, Gabriele|Wagner, Ernst|Nelson, Peter J|Spitzweg, Christine
PMID: 29724129
Journal: Future Oncol. 2018 Jun;14(13):1261-1271.
Title: CXCL12 and CXCR4 polymorphisms and expressions in peripheral blood from patients of hepatocellular carcinoma.
Author: Qin, Li-Feng|Qin, Jin-Mei|Zhang, Ji-Qiao|Lv, Xiao-Ping|Huang, Li-Yi|Wang, Jing-Jing
PMID: 29741398
Journal: Cell Commun Signal. 2018 May 21;16(1):22.
Title: High co-expression of the SDF1/CXCR4 axis in hepatocarcinoma cells is regulated by AnnexinA7 in vitro and in vivo.
Author: Wang, Jingwen|Huang, Yuhong|Zhang, Jun|Xing, Boyi|Xuan, Wei|Wang, Honghai|Huang, He|Yang, Jiayu|Tang, Jianwu
PMID: 29783989
Journal: Cytokine. 2018 Sep;109:11-16.
Title: Role of CXCL12 and CXCR4 in the pathogenesis of hematological malignancies.
Author: Peled, Amnon|Klein, Shiri|Beider, Katia|Burger, Jan A|Abraham, Michal
PMID: 29903571