Primary Site >> Stomach Cancer

Gene >> CLDN18

Journal: BMC Cancer. 2006 Jul 12;6:186.
Title: The claudin gene family: expression in normal and neoplastic tissues.
Author: Hewitt, Kyle J|Agarwal, Rachana|Morin, Patrice J
PMID: 16836752
Journal: J Pathol. 2006 Apr;208(5):633-42.
Title: Down-regulation of the claudin-18 gene, identified through serial analysis of gene expression data analysis, in gastric cancer with an intestinal phenotype.
Author: Sanada, Y|Oue, N|Mitani, Y|Yoshida, K|Nakayama, H|Yasui, W
PMID: 16435283
Journal: Scand J Surg. 2006;95(4):225-31.
Title: Molecular pathobiology of gastric cancer.
Author: Yasui, W|Sentani, K|Motoshita, J|Nakayama, H
PMID: 17249269
Journal: Cancer Sci. 2007 Jul;98(7):1014-9. Epub 2007 Apr 24.
Title: Gastric and intestinal claudin expression at the invasive front of gastric carcinoma.
Author: Matsuda, Yoshiko|Semba, Shuho|Ueda, Junya|Fuku, Takeichi|Hasuo, Tadateru|Chiba, Hideki|Sawada, Norimasa|Kuroda, Yoshikazu|Yokozaki, Hiroshi
PMID: 17459057
Journal: Am J Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G336-43. Epub 2007 Nov
Title: Transcriptional activation of the human claudin-18 gene promoter through two AP-1 motifs in PMA-stimulated MKN45 gastric cancer cells.
Author: Yano, Koichi|Imaeda, Takashi|Niimi, Tomoaki
PMID: 18032479
Journal: Pathol Int. 2008 Mar;58(3):156-63.
Title: Cdx2 transcription factor regulates claudin-3 and claudin-4 expression during intestinal differentiation of gastric carcinoma.
Author: Satake, Shinya|Semba, Shuho|Matsuda, Yoshiko|Usami, Yu|Chiba, Hideki|Sawada, Norimasa|Kasuga, Masato|Yokozaki, Hiroshi
PMID: 18251778
Journal: Pathol Int. 2008 Jun;58(6):371-7.
Title: Prognostic significance of intestinal claudins in high-risk synchronous and metachronous multiple gastric epithelial neoplasias after initial endoscopic submucosal dissection.
Author: Semba, Shuho|Hasuo, Tadateru|Satake, Shinya|Nakayama, Fumihito|Yokozaki, Hiroshi
PMID: 18477216
Journal: Am J Surg Pathol. 2008 Aug;32(8):1182-9.
Title: Immunohistochemical staining of Reg IV and claudin-18 is useful in the diagnosis of gastrointestinal signet ring cell carcinoma.
Author: Sentani, Kazuhiro|Oue, Naohide|Tashiro, Takashi|Sakamoto, Naoya|Nishisaka, Takashi|Fukuhara, Toshiyuki|Taniyama, Kiyomi|Matsuura, Hiroo|Arihiro, Koji|Ochiai, Atsushi|Yasui, Wataru
PMID: 18580680
Journal: Pathol Int. 2009 Mar;59(3):121-36.
Title: Transcriptome dissection of gastric cancer: identification of novel diagnostic and therapeutic targets from pathology specimens.
Author: Yasui, Wataru|Oue, Naohide|Sentani, Kazuhiro|Sakamoto, Naoya|Motoshita, Junichi
PMID: 19261089
Journal: J Histochem Cytochem. 2009 Aug;57(8):775-85.
Title: Epstein-Barr virus-associated gastric carcinoma: a distinct carcinoma of gastric phenotype by claudin expression profiling.
Author: Shinozaki, Aya|Ushiku, Tetsuo|Morikawa, Teppei|Hino, Rumi|Sakatani, Takashi|Uozaki, Hiroshi|Fukayama, Masashi
PMID: 19398608
Journal: J Cell Biochem. 2011 Jul;112(7):1761-72.
Title: Transcriptional regulation of claudin-18 via specific protein kinase C signaling pathways and modification of DNA methylation in human pancreatic cancer cells.
Author: Ito, Tatsuya|Kojima, Takashi|Yamaguchi, Hiroshi|Kyuno, Daisuke|Kimura, Yasutoshi|Imamura, Masafumi|Takasawa, Akira|Murata, Masaki|Tanaka, Satoshi|Hirata, Koichi|Sawada, Norimasa
PMID: 21381080
Journal: J Histochem Cytochem. 2011 Oct;59(10):942-52.
Title: Claudin-18 is an early-stage marker of pancreatic carcinogenesis.
Author: Tanaka, Mariko|Shibahara, Junji|Fukushima, Noriyoshi|Shinozaki, Aya|Umeda, Makoto|Ishikawa, Shumpei|Kokudo, Norihiro|Fukayama, Masashi
PMID: 21832145
Journal: Pathol Res Pract. 2011 Oct 15;207(10):608-12.
Title: Molecular pathology of gastric cancer: research and practice.
Author: Yasui, Wataru|Sentani, Kazuhiro|Sakamoto, Naoya|Anami, Katsuhiro|Naito, Yutaka|Oue, Naohide
PMID: 22005013
Journal: Infect Agent Cancer. 2012 Aug 28;7(1):21.
Title: Epstein-barr virus infected gastric adenocarcinoma expresses latent and lytic viral transcripts and has a distinct human gene expression profile.
Author: Tang, Weihua|Morgan, Douglas R|Meyers, Michael O|Dominguez, Ricardo L|Martinez, Enrique|Kakudo, Kennichi|Kuan, Pei Fen|Banet, Natalie|Muallem, Hind|Woodward, Kimberly|Speck, Olga|Gulley, Margaret L
PMID: 22929309
Journal: PLoS One. 2013 Sep 20;8(9):e74757.
Title: Down-regulation of claudin-18 is associated with the proliferative and invasive potential of gastric cancer at the invasive front.
Author: Oshima, Tadayuki|Shan, Jing|Okugawa, Takuya|Chen, Xin|Hori, Kazutoshi|Tomita, Toshihiko|Fukui, Hirokazu|Watari, Jiro|Miwa, Hiroto
PMID: 24073219
Journal: Oncol Rep. 2014 Oct;32(4):1473-80.
Title: 4-Amino-2-trifluoromethyl-phenyl retinate inhibits the migration of BGC-823 human gastric cancer cells by downregulating the phosphorylation level of MLC II.
Author: Hu, Anla|Yang, Yanyan|Zhang, Sumei|Zhou, Qing|Wei, Wei|Wang, Yuan
PMID: 25051015
Journal: World J Surg. 2014 Aug;38(8):2058-64.
Title: cDNA-microarray analysis as a new tool to predict lymph node metastasis in gastric cancer.
Author: Ojetti, V|Persiani, R|Cananzi, F C M|Sensi, C|Piscaglia, A C|Saulnier, N|Biondi, A|Gasbarrini, A|D'Ugo, D
PMID: 24696059
Journal: Int J Surg. 2014;12(2):156-62.
Title: Expression of claudin-7 and loss of claudin-18 correlate with poor prognosis in gastric cancer.
Author: Jun, Kyong-Hwa|Kim, Ji-Hyun|Jung, Ji-Han|Choi, Hyun-Joo|Chin, Hyung-Min
PMID: 24333468
Journal: Dig Dis Sci. 2014 Aug;59(8):1754-63.
Title: miR-1303 targets claudin-18 gene to modulate proliferation and invasion of gastric cancer cells.
Author: Zhang, Shi-jie|Feng, Jian-fang|Wang, Lei|Guo, Wei|Du, Yu-wen|Ming, Liang|Zhao, Guo-qiang
PMID: 24647998
Journal: Gastric Cancer. 2015 Jan;18(1):119-28.
Title: New molecular staging with G-factor supplements TNM classification in gastric cancer: a multicenter collaborative research by the Japan Society for Gastroenterological Carcinogenesis G-Project committee.
Author: Sawada, Tetsuji|Yashiro, Masakazu|Sentani, Kazuhiro|Oue, Naohide|Yasui, Wataru|Miyazaki, Kohji|Kai, Keita|Fushida, Sachio|Fujimura, Takashi|Ohira, Masaichi|Kakeji, Yoshihiro|Natsugoe, Shoji|Shirabe, Ken|Nomura, Sachiyo|Shimada, Yutaka|Tomita, Naohiro|Hira
PMID: 24488015
Journal: Hum Pathol. 2015 May;46(5):643-56.
Title: Gastric-type expression signature in serrated pathway-associated colorectal tumors.
Author: Kim, Jung Ho|Kim, Kyung-Ju|Rhee, Ye-Young|Bae, Jeong Mo|Cho, Nam-Yun|Lee, Hye Seung|Kang, Gyeong Hoon
PMID: 25704805
Journal: Cancer Sci. 2015 Aug;106(8):951-8.
Title: Clinicopathologic and molecular characteristics of gastric cancer showing gastric and intestinal mucin phenotype.
Author: Oue, Naohide|Sentani, Kazuhiro|Sakamoto, Naoya|Yasui, Wataru
PMID: 26033320
Journal: Cell Rep. 2015 Jul 14;12(2):272-85.
Title: Recurrent Fusion Genes in Gastric Cancer: CLDN18-ARHGAP26 Induces Loss of Epithelial Integrity.
Author: Yao, Fei|Kausalya, Jaya P|Sia, Yee Yen|Teo, Audrey S M|Lee, Wah Heng|Ong, Alicia G M|Zhang, Zhenshui|Tan, Joanna H J|Li, Guoliang|Bertrand, Denis|Liu, Xingliang|Poh, Huay Mei|Guan, Peiyong|Zhu, Feng|Pathiraja, Thushangi Nadeera|Ariyaratne, Pramila N|Rao,
PMID: 26146084
Journal: Gastric Cancer. 2016 Apr;19(2):403-11.
Title: RHOA mutation in diffuse-type gastric cancer: a comparative clinicopathology analysis of 87 cases.
Author: Ushiku, Tetsuo|Ishikawa, Shumpei|Kakiuchi, Miwako|Tanaka, Atsushi|Katoh, Hiroto|Aburatani, Hiroyuki|Lauwers, Gregory Y|Fukayama, Masashi
PMID: 25823974
Journal: Oncotarget. 2016 Sep 27;7(39):64168-64181.
Title: Coupling CDH17 and CLDN18 markers for comprehensive membrane-targeted detection of human gastric cancer.
Author: Matsusaka, Keisuke|Ushiku, Tetsuo|Urabe, Masayuki|Fukuyo, Masaki|Abe, Hiroyuki|Ishikawa, Shumpei|Seto, Yasuyuki|Aburatani, Hiroyuki|Hamakubo, Takao|Kaneda, Atsushi|Fukayama, Masashi
PMID: 27580354
Journal: J Hematol Oncol. 2017 May 12;10(1):105.
Title: Anti-claudin 18.2 antibody as new targeted therapy for advanced gastric cancer.
Author: Singh, Prabhsimranjot|Toom, Sudhamshi|Huang, Yiwu
PMID: 28494772
Journal: Oncotarget. 2018 May 1;9(33):23198-23207.
Title: DGC-specific RHOA mutations maintained cancer cell survival and promoted cell migration via ROCK inactivation.
Author: Nishizawa, Takashi|Nakano, Kiyotaka|Harada, Aya|Kakiuchi, Miwako|Funahashi, Shin-Ichi|Suzuki, Masami|Ishikawa, Shumpei|Aburatani, Hiroyuki
PMID: 29796182
Journal: Eur J Cancer. 2018 Sep;100:17-26.
Title: A phase I dose-escalation study of IMAB362 (Zolbetuximab) in patients with advanced gastric and gastro-oesophageal junction cancer.
Author: Sahin, Ugur|Schuler, Martin|Richly, Heike|Bauer, Stefan|Krilova, Anna|Dechow, Tobias|Jerling, Markus|Utsch, Magdalena|Rohde, Christoph|Dhaene, Karl|Huber, Christoph|Tureci, Ozlem
PMID: 29936063
Journal: Nat Commun. 2018 Jun 30;9(1):2447.
Title: Prognostic significance of frequent CLDN18-ARHGAP26/6 fusion in gastric signet-ring cell cancer.
Author: Shu, Yang|Zhang, Weihan|Hou, Qianqian|Zhao, Linyong|Zhang, Shouyue|Zhou, Jiankang|Song, Xiaohai|Zhang, Yan|Jiang, Dan|Chen, Xinzu|Wang, Peiqi|Xia, Xuyang|Liao, Fei|Yin, Dandan|Chen, Xiaolong|Zhou, Xueyan|Zhang, Duyu|Yin, Senlin|Yang, Kun|Liu, Jianping|Fu,
PMID: 29961079
Journal: Oncotarget. 2018 Jun 29;9(50):29336-29350.
Title: Frequent CLDN18-ARHGAP fusion in highly metastatic diffuse-type gastric cancer with relatively early onset.
Author: Tanaka, Atsushi|Ishikawa, Shumpei|Ushiku, Tetsuo|Yamazawa, Sho|Katoh, Hiroto|Hayashi, Akimasa|Kunita, Akiko|Fukayama, Masashi
PMID: 30034621
Journal: Gastroenterology. 2018 Sep 6. pii: S0016-5085(18)34930-8.
Title: Loss of Tight Junction Protein Claudin 18 Promotes Progressive Neoplasia Development in Mouse Stomach.
Author: Hagen, Susan J|Ang, Lay-Hong|Zheng, Yi|Karahan, Salih N|Wu, Jessica|Wang, Yaoyu E|Caron, Tyler J|Gad, Aniket P|Muthupalani, Sureshkumar|Fox, James G
PMID: 30195448
Journal: J Natl Cancer Inst. 2018 Sep 6. pii: 5091914.
Title: Claudin18.2-Specific Chimeric Antigen Receptor Engineered T Cells for the Treatment of Gastric Cancer.
Author: Jiang, Hua|Shi, Zhimin|Wang, Peng|Wang, Cong|Yang, Linlin|Du, Guoxiu|Zhang, Honghong|Shi, Bizhi|Jia, Jie|Li, Qixiang|Wang, Huamao|Li, Zonghai
PMID: 30203099
Journal: Cell Stem Cell. 2018 Oct 13. pii: S1934-5909(18)30480-6.
Title: A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening.
Author: Yan, Helen H N|Siu, Hoi Cheong|Law, Simon|Ho, Siu Lun|Yue, Sarah S K|Tsui, Wai Yin|Chan, Dessy|Chan, April S|Ma, Stephanie|Lam, Ka On|Bartfeld, Sina|Man, Alice H Y|Lee, Bernard C H|Chan, Annie S Y|Wong, Jason W H|Cheng, Priscilla S W|Chan, Anthony K W|Zha
PMID: 30344100
Journal: Nat Commun. 2018 Oct 25;9(1):4439.
Title: RhoGAP domain-containing fusions and PPAPDC1A fusions are recurrent and prognostic in diffuse gastric cancer.
Author: Yang, Hanna|Hong, Dongwan|Cho, Soo Young|Park, Young Soo|Ko, Woo Ri|Kim, Ju Hee|Hur, Hoon|Lee, Jongkeun|Kim, Su-Jin|Kwon, Sun Young|Lee, Jae-Hyuk|Park, Do Youn|Song, Kyu Sang|Chang, Heekyung|Ryu, Min-Hee|Cho, Kye Soo|Kang, Jeong Won|Kook, Myeong-Cherl|Thi
PMID: 30361512