Primary Site >> Colorectal Cancer

Gene >> CHEK2

1.
Journal: Oncogene. 2001 Sep 6;20(39):5503-10.
Title: Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway.
Author: Falck, J|Lukas, C|Protopopova, M|Lukas, J|Selivanova, G|Bartek, J
PMID: 11571648
2.
Journal: Leuk Lymphoma. 2001 Jul;42(3):517-20.
Title: Analysis of the CHK2 gene in lymphoid malignancies.
Author: Tavor, S|Takeuchi, S|Tsukasaki, K|Miller, C W|Hofmann, W K|Ikezoe, T|Said, J W|Koeffler, H P
PMID: 11699418
3.
Journal: Fam Cancer. 2001;1(3-4):189-95.
Title: Apparent Mendelian inheritance of breast and colorectal cancer: chance, genetic heterogeneity or a new gene?
Author: Lipton, L|Thomas, H J|Eeles, R A|Houlston, R S|Longmuir, M|Davison, R|Hodgson, S V|Murday, V A|Norbury, C G|Taylor, C|Tomlinson, I P
PMID: 14574178
4.
Journal: Breast Cancer Res. 2002;4(3):R4. Epub 2002 Mar 20.
Title: Mutation analysis of the CHK2 gene in breast carcinoma and other cancers.
Author: Ingvarsson, Sigurdur|Sigbjornsdottir, Bjarnveig I|Huiping, Chen|Hafsteinsdottir, Sigridur H|Ragnarsson, Gisli|Barkardottir, Rosa B|Arason, Adalgeir|Egilsson, Valgardur|Bergthorsson, Jon T H
PMID: 12052256
5.
Journal: Cancer Res. 2002 Oct 15;62(20):5743-8.
Title: UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1.
Author: Yu, Qiang|La Rose, JiHyun|Zhang, Hongliang|Takemura, Haruyuki|Kohn, Kurt W|Pommier, Yves
PMID: 12384533
6.
Journal: Oncogene. 2003 Apr 10;22(14):2110-20.
Title: The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase.
Author: Franchitto, Annapaola|Pichierri, Pietro|Piergentili, Rita|Crescenzi, Marco|Bignami, Margherita|Palitti, Fabrizio
PMID: 12687013
7.
Journal: Am J Hum Genet. 2003 May;72(5):1308-14. Epub 2003 Apr 10.
Title: The CHEK2 1100delC mutation identifies families with a hereditary breast and colorectal cancer phenotype.
Author: Meijers-Heijboer, Hanne|Wijnen, Juul|Vasen, Hans|Wasielewski, Marijke|Wagner, Anja|Hollestelle, Antoinette|Elstrodt, Fons|van den Bos, Renate|de Snoo, Anja|Fat, Grace Tjon A|Brekelmans, Cecile|Jagmohan, Shantie|Franken, Patrick|Verkuijlen, Paul|van den Ou
PMID: 12690581
8.
Journal: Cancer Lett. 2003 Oct 28;200(2):149-52.
Title: Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma.
Author: Lipton, Lara|Fleischmann, Christina|Sieber, Oliver M|Thomas, Huw J W|Hodgson, Shirley V|Tomlinson, Ian P M|Houlston, Richard S
PMID: 14568168
9.
Journal: J Med Genet. 2003 Oct;40(10):e110.
Title: CHEK2 1100delC and colorectal cancer.
Author: Kilpivaara, O|Laiho, P|Aaltonen, L A|Nevanlinna, H
PMID: 14569133
10.
Journal: Oncogene. 2004 May 27;23(25):4353-61.
Title: The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe.
Author: Castedo, Maria|Perfettini, Jean-Luc|Roumier, Thomas|Yakushijin, Kenichi|Horne, David|Medema, Rene|Kroemer, Guido
PMID: 15048074
11.
Journal: J Biol Chem. 2004 Jun 11;279(24):25813-22. Epub 2004 Apr 8.
Title: Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C.
Author: Singh, Shivendra V|Herman-Antosiewicz, Anna|Singh, Ajita V|Lew, Karen L|Srivastava, Sanjay K|Kamath, Ravindra|Brown, Kevin D|Zhang, Lin|Baskaran, Rajasekaran
PMID: 15073169
12.
Journal: Cytogenet Genome Res. 2004;104(1-4):333-40.
Title: Possible causes of chromosome instability: comparison of chromosomal abnormalities in cancer cell lines with mutations in BRCA1, BRCA2, CHK2 and BUB1.
Author: Grigorova, M|Staines, J M|Ozdag, H|Caldas, C|Edwards, P A W
PMID: 15162061
13.
Journal: Mol Pharmacol. 2004 Jul;66(1):153-60.
Title: Enhanced 7-ethyl-10-hydroxycamptothecin (SN-38) lethality by methylselenocysteine is associated with Chk2 phosphorylation at threonine-68 and down-regulation of Cdc6 expression.
Author: Yin, Ming-Biao|Li, Zhan-Rong|Cao, Shousong|Durrani, Farukh A|Azrak, Rami G|Frank, Cheryl|Rustum, Youcef M
PMID: 15213307
14.
Journal: Breast Cancer Res. 2004;6(4):R366-71. Epub 2004 May 14.
Title: No germline mutations in the histone acetyltransferase gene EP300 in BRCA1 and BRCA2 negative families with breast cancer and gastric, pancreatic, or colorectal cancer.
Author: Campbell, Ian G|Choong, David|Chenevix-Trench, Georgia
PMID: 15217503
15.
Journal: J Biol Chem. 2004 Sep 17;279(38):39584-92. Epub 2004 Jul 20.
Title: ATM-dependent CHK2 activation induced by anticancer agent, irofulven.
Author: Wang, Jian|Wiltshire, Timothy|Wang, Yutian|Mikell, Carmenza|Burks, Julian|Cunningham, Cynthia|Van Laar, Emily S|Waters, Stephen J|Reed, Eddie|Wang, Weixin
PMID: 15269203
16.
Journal: Cell Cycle. 2004 Sep;3(9):1177-81. Epub 2004 Sep 13.
Title: Chk1, but not Chk2, is involved in the cellular response to DNA damaging agents: differential activity in cells expressing or not p53.
Author: Carrassa, Laura|Broggini, Massimo|Erba, Eugenio|Damia, Giovanna
PMID: 15326376
17.
Journal: Mol Cancer Ther. 2004 Sep;3(9):1147-57.
Title: CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses.
Author: Yan, Tao|Desai, Anand B|Jacobberger, James W|Sramkoski, R Michael|Loh, Tamalette|Kinsella, Timothy J
PMID: 15367709
18.
Journal: Cancer Res. 2004 Sep 15;64(18):6588-94.
Title: 5-fluoro-2'-deoxyuridine-induced cdc25A accumulation correlates with premature mitotic entry and clonogenic death in human colon cancer cells.
Author: Parsels, Leslie Anne|Parsels, Joshua David|Tai, Daniel Chung-Ho|Coughlin, Daniel James|Maybaum, Jonathan
PMID: 15374972
19.
Journal: Cancer Res. 2004 Sep 15;64(18):6635-44.
Title: Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic catastroph
Author: Tse, Archie N|Schwartz, Gary K
PMID: 15374978
20.
Journal: Am J Hum Genet. 2004 Dec;75(6):1131-5.
Title: CHEK2 is a multiorgan cancer susceptibility gene.
Author: Cybulski, C|Gorski, B|Huzarski, T|Masojc, B|Mierzejewski, M|Debniak, T|Teodorczyk, U|Byrski, T|Gronwald, J|Matyjasik, J|Zlowocka, E|Lenner, M|Grabowska, E|Nej, K|Castaneda, J|Medrek, K|Szymanska, A|Szymanska, J|Kurzawski, G|Suchy, J|Oszurek, O|Witek, A|Na
PMID: 15492928
21.
Journal: J Pathol. 2005 Jun;206(2):198-204.
Title: Homozygosity for a CHEK2*1100delC mutation identified in familial colorectal cancer does not lead to a severe clinical phenotype.
Author: van Puijenbroek, Marjo|van Asperen, Christi J|van Mil, Anneke|Devilee, Peter|van Wezel, Tom|Morreau, Hans
PMID: 15818573
22.
Journal: Genes Chromosomes Cancer. 2005 Aug;43(4):377-82.
Title: Colorectal cancer and the CHEK2 1100delC mutation.
Author: de Jong, Mirjam M|Nolte, Ilja M|Te Meerman, Gerard J|van der Graaf, Winette T A|Mulder, Marcel J|van der Steege, Gerrit|Bruinenberg, Marcel|Schaapveld, Michael|Niessen, Renee C|Berends, Maran J W|Sijmons, Rolf H|Hofstra, Robert M W|de Vries, Elisabeth G E
PMID: 15852425
23.
Journal: Fam Cancer. 2005;4(2):183-6.
Title: The CHEK2 1100delC allele is not relevant for risk assessment in HNPCC and HBCC Spanish families.
Author: Sanchez de Abajo, Ana|de la Hoya, Miguel|Godino, Javier|Furio, Vicente|Tosar, Alicia|Perez-Segura, Pedro|Diaz-Rubio, Eduardo|Caldes, Trinidad
PMID: 15951971
24.
Journal: FEBS Lett. 2005 Jul 4;579(17):3683-90.
Title: The p53 pathway is synergized by p38 MAPK signaling to mediate 11,11'-dideoxyverticillin-induced G2/M arrest.
Author: Chen, Yi|Miao, Ze-Hong|Zhao, Wei-Min|Ding, Jian
PMID: 15963507
25.
Journal: Oncogene. 2006 May 11;25(20):2839-49.
Title: p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.
Author: Furuta, T|Hayward, R L|Meng, L-H|Takemura, H|Aune, G J|Bonner, W M|Aladjem, M I|Kohn, K W|Pommier, Y
PMID: 16407843
26.
Journal: Nucleic Acids Res. 2006 Feb 2;34(3):880-92. Print 2006.
Title: Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells.
Author: Hiyama, Takashi|Katsura, Mari|Yoshihara, Takashi|Ishida, Mari|Kinomura, Aiko|Tonda, Tetsuji|Asahara, Toshimasa|Miyagawa, Kiyoshi
PMID: 16456034
27.
Journal: BMC Cancer. 2006 Mar 15;6:64.
Title: CHEK2 1100delC in patients with metachronous cancers of the breast and the colorectum.
Author: Isinger, Anna|Bhat, Misha|Borg, Ake|Nilbert, Mef
PMID: 16539695
28.
Journal: J Med Genet. 2006 Jul;43(7):e34.
Title: CHEK2 I157T associates with familial and sporadic colorectal cancer.
Author: Kilpivaara, O|Alhopuro, P|Vahteristo, P|Aaltonen, L A|Nevanlinna, H
PMID: 16816021
29.
Journal: Fam Cancer. 2006;5(4):305-8. Epub 2006 Jul 20.
Title: Low frequency of CHEK2 mutations in familial pancreatic cancer.
Author: Bartsch, Detlef K|Krysewski, Kristina|Sina-Frey, Mercedes|Fendrich, Volker|Rieder, Harald|Langer, Peter|Kress, Ralf|Schneider, Margarete|Hahn, Stephan A|Slater, Emily P
PMID: 16858628
30.
Journal: Planta Med. 2006 Aug;72(10):917-23.
Title: Inhibition of colon cancer (HT-29) cell proliferation by a triterpenoid isolated from Azadirachta indica is accompanied by cell cycle arrest and up-regulation of p21.
Author: Roy, Molay Kumar|Kobori, Masuko|Takenaka, Makiko|Nakahara, Kazuhiko|Shinmoto, Hiroshi|Tsushida, Tojiro
PMID: 16858664
31.
Journal: J Biol Chem. 2006 Oct 13;281(41):30814-23. Epub 2006 Aug 10.
Title: Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.
Author: Takemura, Haruyuki|Rao, V Ashutosh|Sordet, Olivier|Furuta, Takahisa|Miao, Ze-Hong|Meng, Linghua|Zhang, Hongliang|Pommier, Yves
PMID: 16905549
32.
Journal: Clin Genet. 2006 Nov;70(5):388-95.
Title: Inherited association of breast and colorectal cancer: limited role of CHEK2 compared with high-penetrance genes.
Author: Naseem, H|Boylan, J|Speake, D|Leask, K|Shenton, A|Lalloo, F|Hill, J|Trump, D|Evans, D G R
PMID: 17026620
33.
Journal: Clin Cancer Res. 2006 Dec 1;12(23):6967-72.
Title: Genetic and epigenetic analysis of CHEK2 in sporadic breast, colon, and ovarian cancers.
Author: Williams, Louise H|Choong, David|Johnson, Sandra A|Campbell, Ian G
PMID: 17145815
34.
Journal: Cancer Epidemiol Biomarkers Prev. 2006 Dec;15(12):2542-5.
Title: A multicenter study of cancer incidence in CHEK2 1100delC mutation carriers.
Author: Thompson, Deborah|Seal, Sheila|Schutte, Mieke|McGuffog, Lesley|Barfoot, Rita|Renwick, Anthony|Eeles, Rosalind|Sodha, Nayanta|Houlston, Richard|Shanley, Susan|Klijn, Jan|Wasielewski, Marijke|Chang-Claude, Jenny|Futreal, P Andrew|Weber, Barbara L|Nathanson,
PMID: 17164383
35.
Journal: Anticancer Res. 2006 Nov-Dec;26(6C):4885-8.
Title: The CHEK2 1100delC variant in Swedish colorectal cancer.
Author: Djureinovic, Tatjana|Lindblom, Annika|Dalen, Johan|Dedorson, Stefan|Edler, David|Hjern, Fredrik|Holm, Jorn|Lenander, Claes|Lindforss, Ulrik|Lundqvist, Nils|Olivecrona, Hans|Olsson, Louise|Pahlman, Lars|Rutegard, Jorgen|Smedh, Kennet|Tornqvist, Anders|Eibe
PMID: 17214356
36.
Journal: Hered Cancer Clin Pract. 2006 Jan 15;4(1):48-51.
Title: Pilot study on low penetrance breast and colorectal cancer predisposition markers in latvia.
Author: Irmejs, Arvids|Miklasevics, Edvins|Boroschenko, Viktors|Gardovskis, Andris|Vanags, Andrejs|Melbarde-Gorkusa, Inga|Bitina, Marianna|Suchy, Janina|Gardovskis, Janis
PMID: 20223004
37.
Journal: J Clin Oncol. 2007 Jan 1;25(1):57-63. Epub 2006 Jul 31.
Title: Increased risk of breast cancer associated with CHEK2*1100delC.
Author: Weischer, Maren|Bojesen, Stig Egil|Tybjaerg-Hansen, Anne|Axelsson, Christen Kirk|Nordestgaard, Borge Gronne
PMID: 16880452
38.
Journal: Oncogene. 2007 Mar 1;26(10):1449-58. Epub 2006 Aug 28.
Title: The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase.
Author: Oliva-Trastoy, M|Berthonaud, V|Chevalier, A|Ducrot, C|Marsolier-Kergoat, M-C|Mann, C|Leteurtre, F
PMID: 16936775
39.
Journal: Eur J Hum Genet. 2007 Feb;15(2):237-41. Epub 2006 Nov 15.
Title: Germline CHEK2 mutations and colorectal cancer risk: different effects of a missense and truncating mutations?
Author: Cybulski, Cezary|Wokolorczyk, Dominika|Kladny, Jozef|Kurzawski, Grzegorz|Suchy, Joanna|Grabowska, Ewa|Gronwald, Jacek|Huzarski, Tomasz|Byrski, Tomasz|Gorski, Bohdan|D Ecedil Bniak, Tadeusz|Narod, Steven A|Lubinski, Jan
PMID: 17106448
40.
Journal: J Pathol. 2007 Mar;211(4):471-80.
Title: Evidence for the receipt of DNA damage stimuli by PML nuclear domains.
Author: Varadaraj, A|Dovey, C L|Laredj, L|Ferguson, B|Alexander, C E|Lubben, N|Wyllie, A H|Rich, T
PMID: 17206596
41.
Journal: Oncol Rep. 2007 Mar;17(3):597-603.
Title: Lidamycin induces marked G2 cell cycle arrest in human colon carcinoma HT-29 cells through activation of p38 MAPK pathway.
Author: Liu, Xia|Bian, Chunjing|Ren, Kaihuan|Jin, Haixia|Li, Baowei|Shao, Rong-Guang
PMID: 17273739
42.
Journal: Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):572-6.
Title: Epistatic relationship between the cancer susceptibility genes CHEK2 and p27.
Author: Cybulski, Cezary|Gliniewicz, Bartlomiej|Sikorski, Andrzej|Kladny, Jozef|Huzarski, Tomasz|Gronwald, Jacek|Byrski, Tomasz|Debniak, Tadeusz|Gorski, Bohdan|Jakubowska, Anna|Wokolorczyk, Dominika|Narod, Steven A|Lubinski, Jan
PMID: 17372254
43.
Journal: Carcinogenesis. 2007 Oct;28(10):2207-17.
Title: Aspirin blocks proliferation in colon cells by inducing a G1 arrest and apoptosis through activation of the checkpoint kinase ATM.
Author: Luciani, M Gloria|Campregher, Christoph|Gasche, Christoph
PMID: 17510082
44.
Journal: Cancer Res. 2007 Sep 15;67(18):8791-9.
Title: Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library.
Author: Lally, Brian E|Geiger, Geoffrey A|Kridel, Steven|Arcury-Quandt, Alice E|Robbins, Michael E|Kock, Nancy D|Wheeler, Kenneth|Peddi, Prakash|Georgakilas, Alexandros|Kao, Gary D|Koumenis, Constantinos
PMID: 17875720
45.
Journal: Cancer Res. 2007 Oct 15;67(20):9971-9.
Title: Batracylin (NSC 320846), a dual inhibitor of DNA topoisomerases I and II induces histone gamma-H2AX as a biomarker of DNA damage.
Author: Rao, V Ashutosh|Agama, Keli|Holbeck, Susan|Pommier, Yves
PMID: 17942930
46.
Journal: Chin Med J (Engl). 2007 Dec 5;120(23):2119-23.
Title: Mutation analysis of the checkpoint kinase 2 gene in colorectal cancer cell lines.
Author: Liu, Wei-dong|Zhong, Bai-yun|Zhang, Yang-de|Choi, Gyu-seog
PMID: 18167186
47.
Journal: Carcinogenesis. 2008 Apr;29(4):762-5.
Title: Constitutional CHEK2 mutations are associated with a decreased risk of lung and laryngeal cancers.
Author: Cybulski, Cezary|Masojc, Bartlomiej|Oszutowska, Dorota|Jaworowska, Ewa|Grodzki, Tomasz|Waloszczyk, Piotr|Serwatowski, Piotr|Pankowski, Juliusz|Huzarski, Tomasz|Byrski, Tomasz|Gorski, Bohdan|Jakubowska, Anna|Debniak, Tadeusz|Wokolorczyk, Dominika|Gronwald,
PMID: 18281249
48.
Journal: Am J Physiol Gastrointest Liver Physiol. 2008 May;294(5):G1235-44.
Title: CUGBP2 downregulation by prostaglandin E2 protects colon cancer cells from radiation-induced mitotic catastrophe.
Author: Natarajan, Gopalan|Ramalingam, Satish|Ramachandran, Ilangovan|May, Randal|Queimado, Lurdes|Houchen, Courtney W|Anant, Shrikant
PMID: 18325984
49.
Journal: Oncogene. 2008 Jul 31;27(33):4544-56.
Title: Translation regulatory factor RBM3 is a proto-oncogene that prevents mitotic catastrophe.
Author: Sureban, S M|Ramalingam, S|Natarajan, G|May, R|Subramaniam, D|Bishnupuri, K S|Morrison, A R|Dieckgraefe, B K|Brackett, D J|Postier, R G|Houchen, C W|Anant, S
PMID: 18427544
50.
Journal: Carcinogenesis. 2008 Jun;29(6):1258-66.
Title: Mesalazine negatively regulates CDC25A protein expression and promotes accumulation of colon cancer cells in S phase.
Author: Stolfi, Carmine|Fina, Daniele|Caruso, Roberta|Caprioli, Flavio|Fantini, Massimo Claudio|Rizzo, Angelamaria|Sarra, Massimiliano|Pallone, Francesco|Monteleone, Giovanni
PMID: 18495657
51.
Journal: Mol Cancer Ther. 2008 Jun;7(6):1440-9.
Title: Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins.
Author: Huang, Min|Miao, Ze-Hong|Zhu, Hong|Cai, Yu-Jun|Lu, Wei|Ding, Jian
PMID: 18566216
52.
Journal: Oncogene. 2008 Oct 16;27(47):6093-101.
Title: Novel evidences for a tumor suppressor role of Rev3, the catalytic subunit of Pol zeta.
Author: Brondello, J-M|Pillaire, M J|Rodriguez, C|Gourraud, P-A|Selves, J|Cazaux, C|Piette, J
PMID: 18622427
53.
Journal: Ann Oncol. 2008 Nov;19(11):1875-81.
Title: Telomere shortening is correlated with the DNA damage response and telomeric protein down-regulation in colorectal preneoplastic lesions.
Author: Raynaud, C M|Jang, S J|Nuciforo, P|Lantuejoul, S|Brambilla, E|Mounier, N|Olaussen, K A|Andre, F|Morat, L|Sabatier, L|Soria, J-C
PMID: 18641004
54.
Journal: Clin Cancer Res. 2008 Aug 1;14(15):4989-94.
Title: CHEK2 1100delC is a susceptibility allele for HNPCC-related colorectal cancer.
Author: Wasielewski, Marijke|Vasen, Hans|Wijnen, Juul|Hooning, Maartje|Dooijes, Dennis|Tops, Carli|Klijn, Jan G M|Meijers-Heijboer, Hanne|Schutte, Mieke
PMID: 18676774
55.
Journal: Int J Colorectal Dis. 2008 Dec;23(12):1243-9.
Title: Alterations of Chk1 and Chk2 expression in colon cancer.
Author: Stawinska, Magdalena|Cygankiewicz, Adam|Trzcinski, Radzislaw|Mik, Michal|Dziki, Adam|Krajewska, Wanda M
PMID: 18679694
56.
Journal: Eur J Cancer. 2009 Mar;45(4):618-24.
Title: The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population.
Author: Kleibl, Zdenek|Havranek, Ondrej|Hlavata, Ivona|Novotny, Jan|Sevcik, Jan|Pohlreich, Petr|Soucek, Pavel
PMID: 18996005
57.
Journal: Int J Radiat Biol. 2009 Feb;85(2):167-74.
Title: 1-Methylxanthine enhances the radiosensitivity of tumor cells.
Author: Youn, Hyewon|Hee Kook, Yeon|Oh, Eun-Taex|Jeong, Seong-Yun|Kim, Chulhee|Kyung Choi, Eun|Uk Lim, Byung|Park, Heon Joo
PMID: 19280470
58.
Journal: Br J Cancer. 2009 May 5;100(9):1508-12.
Title: Cancer risks in first-degree relatives of CHEK2 mutation carriers: effects of mutation type and cancer site in proband.
Author: Gronwald, J|Cybulski, C|Piesiak, W|Suchy, J|Huzarski, T|Byrski, T|Gorski, B|Debniak, T|Szwiec, M|Wokolowczyk, D|Matuszewski, M|Sun, P|Lubinski, J|Narod, S A
PMID: 19401704
59.
Journal: Cancer Biol Ther. 2009 Aug;8(16):1559-66. Epub 2009 Aug 8.
Title: Knockdown of Chk1 sensitizes human colon carcinoma HCT116 cells in a p53-dependent manner to lidamycin through abrogation of a G2/M checkpoint and induction of apoptosis.
Author: Pan, Yu|Ren, Kai-Huan|He, Hong-Wei|Shao, Rong-Guang
PMID: 19502782
60.
Journal: Fam Cancer. 2009;8(4):473-8.
Title: Haplotypes of the I157T CHEK2 germline mutation in ethnically diverse populations.
Author: Kaufman, Bella|Laitman, Yael|Gronwald, Jacek|Winqvist, Robert|Irmejs, Arvids|Lubinski, Jan|Pylkas, Katri|Gardovskis, Janis|Miklasevics, Edvins|Friedman, Eitan
PMID: 19609724
61.
Journal: Cell Cycle. 2009 Oct 1;8(19):3157-64. Epub 2009 Oct 3.
Title: Hypoxia-mediated regulation of Cdc25A phosphatase by p21 and miR-21.
Author: de Oliveira, Pierre E Queiroz|Zhang, Lin|Wang, Zhenghe|Lazo, John S
PMID: 19738433
62.
Journal: Neoplasia. 2009 Nov;11(11):1226-34.
Title: Naphthalimides induce G(2) arrest through the ATM-activated Chk2-executed pathway in HCT116 cells.
Author: Zhu, Hong|Miao, Ze-Hong|Huang, Min|Feng, Jian-Ming|Zhang, Zhi-Xiang|Lu, Jin-Jian|Cai, Yu-Jun|Tong, Lin-Jiang|Xu, Yu-Fang|Qian, Xu-Hong|Ding, Jian
PMID: 19881958
63.
Journal: Int J Cancer. 2010 Jun 15;126(12):3005-9.
Title: CHEK2 mutations and HNPCC-related colorectal cancer.
Author: Suchy, Janina|Cybulski, Cezary|Wokolorczyk, Dominika|Oszurek, Oleg|Gorski, Bohdan|Debniak, Tadeusz|Jakubowska, Anna|Gronwald, Jacek|Huzarski, Tomasz|Byrski, Tomasz|Dziuba, Ireneusz|Gogacz, Marek|Wisniowski, Rafal|Wandzel, Piotr|Banaszkiewicz, Zbigniew|Kur
PMID: 19876921
64.
Journal: Am J Physiol Renal Physiol. 2010 Feb;298(2):F293-300.
Title: Inhibitors of histone deacetylases suppress cisplatin-induced p53 activation and apoptosis in renal tubular cells.
Author: Dong, Guie|Luo, Jia|Kumar, Vijay|Dong, Zheng
PMID: 19889954
65.
Journal: J Biol Chem. 2010 Jan 29;285(5):2986-95.
Title: A new isoquinolinium derivative, Cadein1, preferentially induces apoptosis in p53-defective cancer cells with functional mismatch repair via a p38-dependent pathway.
Author: Jang, Eun Ryoung|Ryu, Minsook|Park, Jeong Eun|Kim, Jung-Ho|Lee, Jong-Soo|Song, Kiwon
PMID: 19948725
66.
Journal: Cancer Biol Ther. 2010 Feb;9(3):246-52. Epub 2010 Feb 25.
Title: DNA damage signaling is activated during cancer progression in human colorectal carcinoma.
Author: Oka, Kazuhito|Tanaka, Toshiki|Enoki, Tadahiko|Yoshimura, Koichi|Ohshima, Mako|Kubo, Masayuki|Murakami, Tomoyuki|Gondou, Toshikazu|Minami, Yoshihide|Takemoto, Yoshihiro|Harada, Eijirou|Tsushimi, Takaaki|Li, Tao-Sheng|Traganos, Frank|Darzynkiewicz, Zbigniew
PMID: 20023412
67.
Journal: Cell Cycle. 2010 Jan 15;9(2):312-20. Epub 2010 Jan 23.
Title: A role for Chk2 in DNA damage induced mitotic delays in human colorectal cancer cells.
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Title: Oxaliplatin responses in colorectal cancer cells are modulated by CHK2 kinase inhibitors.
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Title: Enhancement of p53-mutant human colorectal cancer cells radiosensitivity by flavonoid fisetin.
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Title: CHEK2 I157T and colorectal cancer in Bulgaria.
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Title: Genetic testing and prevention of hereditary cancer at the MMCI--over 10 years of experience.
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Title: A novel Chk inhibitor, XL-844, increases human cancer cell radiosensitivity through promotion of mitotic catastrophe.
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Title: Spatholobus suberectus inhibits cancer cell growth by inducing apoptosis and arresting cell cycle at G2/M checkpoint.
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Title: Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2.
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Title: German national case collection for familial pancreatic cancer (FaPaCa): ten years experience.
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Title: Global dissociation of HuR-mRNA complexes promotes cell survival after ionizing radiation.
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Journal: BMC Cancer. 2011 Feb 21;11:79.
Title: A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation.
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Journal: Liver Int. 2011 Apr;31(4):561-71.
Title: Aflatoxin genotoxicity is associated with a defective DNA damage response bypassing p53 activation.
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Journal: Cell Death Dis. 2011 Mar 10;2:e128.
Title: Phosphorylation of SMC1 by ATR is required for desferrioxamine (DFO)-induced apoptosis.
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Journal: Int J Oncol. 2011 Aug;39(2):393-400.
Title: Priming and potentiation of DNA damage response by fibronectin in human colon cancer cells and tumor-derived myofibroblasts.
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Title: 5-Methoxyflavanone induces cell cycle arrest at the G2/M phase, apoptosis and autophagy in HCT116 human colon cancer cells.
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Title: DNA damage signaling in response to 5-fluorouracil in three colorectal cancer cell lines with different mismatch repair and TP53 status.
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Journal: Cancer Res. 2011 Sep 1;71(17):5904-14.
Title: Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells.
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Journal: Eur J Cancer. 2011 Nov;47(17):2546-51.
Title: Meta-analysis of CHEK2 1100delC variant and colorectal cancer susceptibility.
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Title: The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer.
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Title: Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing.
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Journal: Exp Ther Med. 2011 May;2(3):393-397.
Title: Trifluorothymidine exhibits potent antitumor activity via the induction of DNA double-strand breaks.
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Journal: Carcinogenesis. 2012 Feb;33(2):301-11.
Title: Orphan receptor TR3 participates in cisplatin-induced apoptosis via Chk2 phosphorylation to repress intestinal tumorigenesis.
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Title: Potentiation of the novel topoisomerase I inhibitor indenoisoquinoline LMP-400 by the cell checkpoint and Chk1-Chk2 inhibitor AZD7762.
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Title: Investigation of the effects of DNA repair gene polymorphisms on the risk of colorectal cancer.
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Journal: Cancer Epidemiol. 2012 Oct;36(5):453-7.
Title: CHEK2 1100delC, IVS2+1G>A and I157T mutations are not present in colorectal cancer cases from Turkish population.
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Title: Chk2 phosphorylation of survivin-DeltaEx3 contributes to a DNA damage-sensing checkpoint in cancer.
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Journal: Clin Colorectal Cancer. 2012 Dec;11(4):268-74.
Title: Multiplexed protein signal pathway mapping identifies patients with rectal cancer that responds to neoadjuvant treatment.
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Journal: Mol Cancer Ther. 2012 Sep;11(9):1884-93.
Title: Killing of Kras-mutant colon cancer cells via Rac-independent actin remodeling by the betaGBP cytokine, a physiological PI3K inhibitor therapeutically effective in vivo.
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Journal: Asian Pac J Cancer Prev. 2012;13(5):2051-5.
Title: The CHEK2 I157T variant and colorectal cancer susceptibility: a systematic review and meta-analysis.
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Title: CHEK2 1100DELC germline mutation: a frequency study in hereditary breast and colon cancer Brazilian families.
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Journal: Int J Oncol. 2013 May;42(5):1644-53.
Title: Acquired irinotecan resistance is accompanied by stable modifications of cell cycle dynamics independent of MSI status.
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Title: Cell cycle-dependent localization of CHK2 at centrosomes during mitosis.
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Title: The effect of CHEK2 variant I157T on cancer susceptibility: evidence from a meta-analysis.
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Journal: PLoS One. 2013 May 28;8(5):e65369.
Title: MSH3 mismatch repair protein regulates sensitivity to cytotoxic drugs and a histone deacetylase inhibitor in human colon carcinoma cells.
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Journal: Acta Biochim Pol. 2013;60(2):195-8. Epub 2013 Jun 6.
Title: Development of a new, simple and cost-effective diagnostic tool for genetic screening of hereditary colorectal cancer--the DNA microarray assay.
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Journal: Epigenetics. 2013 Jun;8(6):612-23.
Title: HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates.
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Journal: Cytotechnology. 2013 Dec;65(6):973-8.
Title: Genistein-induced G2/M cell cycle arrest of human intestinal colon cancer Caco-2 cells is associated with Cyclin B1 and Chk2 down-regulation.
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Title: Anticancer effect of Tamarix gallica extracts on human colon cancer cells involves Erk1/2 and p38 action on G2/M cell cycle arrest.
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Title: N-Hydroxycinnamide derivatives of osthole presenting genotoxicity and cytotoxicity against human colon adenocarcinoma cells in vitro and in vivo.
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Title: Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRgamma activation.
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Title: In Vitro Antiproliferative Effect of Arthrocnemum indicum Extracts on Caco-2 Cancer Cells through Cell Cycle Control and Related Phenol LC-TOF-MS Identification.
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Title: Genetic variants associated with colorectal cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence.
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Title: Panel-based testing for inherited colorectal cancer: a descriptive study of clinical testing performed by a US laboratory.
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Title: Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells.
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Title: HuR regulates alternative splicing of the TRA2beta gene in human colon cancer cells under oxidative stress.
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Title: Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells.
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Title: SKLB316, a novel small-molecule inhibitor of cell-cycle progression, induces G2/M phase arrest and apoptosis in vitro and inhibits tumor growth in vivo.
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Journal: Mol Biol (Mosk). 2014 Mar-Apr;48(2):243-50.
Title: [Genotyping of BRCA1, BRCA2 and CHEK2 germline mutations in Russian breast cancer patients using diagnostic biochips].
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Title: P53 deficiency-induced Smad1 upregulation suppresses tumorigenesis and causes chemoresistance in colorectal cancers.
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Title: Expression of DNA damage checkpoint 53BP1 is correlated with prognosis, cell proliferation and apoptosis in colorectal cancer.
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Title: Targeting SOD1 induces synthetic lethal killing in BLM- and CHEK2-deficient colorectal cancer cells.
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Title: Identification of novel, in vivo active Chk1 inhibitors utilizing structure guided drug design.
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Title: Erratum: CHEK2 1100DELC germline mutation: a frequency study in hereditary breast and colon cancer Brazilian families.
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Title: Antitumor Activity of Americanin A Isolated from the Seeds of Phytolacca americana by Regulating the ATM/ATR Signaling Pathway and the Skp2-p27 Axis in Human Colon Cancer Cells.
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Journal: Int J Clin Exp Pathol. 2015 Sep 1;8(9):10985-94. eCollection 2015.
Title: Circadian gene expression predicts patient response to neoadjuvant chemoradiation therapy for rectal cancer.
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Journal: Balkan J Med Genet. 2016 Jul 9;18(2):33-36.
Title: The CHEK2 del5395 is a founder mutation without direct effects for cancer risk in the latvian population.
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Journal: Oncogene. 2016 May 5;35(18):2398-406.
Title: The putative oncogene CEP72 inhibits the mitotic function of BRCA1 and induces chromosomal instability.
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Journal: Tumour Biol. 2016 Mar;37(3):3145-53.
Title: ROBO1 deletion as a novel germline alteration in breast and colorectal cancer patients.
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Title: Contribution of rare germline copy number variations and common susceptibility loci in Lynch syndrome patients negative for mutations in the mismatch repair genes.
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Journal: Cancer Med. 2016 Feb;5(2):370-85.
Title: Mus81 knockdown improves chemosensitivity of hepatocellular carcinoma cells by inducing S-phase arrest and promoting apoptosis through CHK1 pathway.
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Title: The downregulation of the RNA-binding protein Staufen2 in response to DNA damage promotes apoptosis.
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Journal: Genet Mol Biol. 2016 May 24;39(2):210-22.
Title: Screening for germline BRCA1, BRCA2, TP53 and CHEK2 mutations in families at-risk for hereditary breast cancer identified in a population-based study from Southern Brazil.
Author: Palmero, Edenir Inez|Alemar, Barbara|Schuler-Faccini, Lavinia|Hainaut, Pierre|Moreira-Filho, Carlos Alberto|Ewald, Ingrid Petroni|Santos, Patricia Koehler Dos|Ribeiro, Patricia Lisboa Izetti|Oliveira, Cristina Brinkmann de Netto|Calvez-Kelm, Florence Le|T
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Title: A Novel Chemotherapeutic Agent to Treat Tumors with DNA Mismatch Repair Deficiencies.
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Title: Deficiency of 53BP1 inhibits the radiosensitivity of colorectal cancer.
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Title: Prevalence of the CHEK2 R95* germline mutation.
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Journal: Cold Spring Harb Mol Case Stud. 2016 Nov;2(6):a001032.
Title: Homozygous inactivation of CHEK2 is linked to a familial case of multiple primary lung cancer with accompanying cancers in other organs.
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Journal: JAMA Oncol. 2017 Apr 1;3(4):464-471.
Title: Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer.
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Journal: J Clin Oncol. 2017 Apr 1;35(10):1086-1095.
Title: Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer.
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Journal: J Obstet Gynaecol Res. 2017 May;43(5):929-934.
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Title: Targeted sequencing of established and candidate colorectal cancer genes in the Colon Cancer Family Registry Cohort.
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Title: AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11.
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Title: Germline Genetic Features of Young Individuals With Colorectal Cancer.
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Title: 53BP1 loss suppresses the radiosensitizing effect of icotinib hydrochloride in colorectal cancer cells.
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Title: Spectrum of APC and MUTYH germ-line mutations in Russian patients with colorectal malignancies.
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Title: shRNAinduced knockdown of the SPERT gene inhibits proliferation and promotes apoptosis of human colorectal cancer RKO cells.
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Title: The expression of telomere-related proteins and DNA damage response and their association with telomere length in colorectal cancer in Saudi patients.
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Title: A452, an HDAC6-selective inhibitor, synergistically enhances the anticancer activity of chemotherapeutic agents in colorectal cancer cells.
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Title: Association of genetic variants in ATR-CHEK1 and ATM-CHEK2 pathway genes with risk of colorectal cancer in a Chinese population.
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Title: MicroRNA expression profiles identify biomarkers for predicting the response to chemoradiotherapy in rectal cancer.
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Title: Chaetominine induces cell cycle arrest in human leukemia K562 and colon cancer SW1116 cells.
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Title: Novel genetic mutations detected by multigene panel are associated with hereditary colorectal cancer predisposition.
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Journal: Cancers (Basel). 2018 Oct 9;10(10). pii: cancers10100373.
Title: Cytoplasmic p21 Mediates 5-Fluorouracil Resistance by Inhibiting Pro-Apoptotic Chk2.
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