Primary Site >> Colorectal Cancer
Gene >> CHEK2
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Ref: Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway. PMID: 11571648 Ref: Analysis of the CHK2 gene in lymphoid malignancies. PMID: 11699418 Ref: Apparent Mendelian inheritance of breast and colorectal cancer: chance, genetic heterogeneity or a new gene? PMID: 14574178 |
Ref: Mutation analysis of the CHK2 gene in breast carcinoma and other cancers. PMID: 12052256 Ref: UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1. PMID: 12384533 |
Ref: The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase. PMID: 12687013 Ref: The CHEK2 1100delC mutation identifies families with a hereditary breast and colorectal cancer phenotype. PMID: 12690581 Ref: Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma. PMID: 14568168 Ref: CHEK2 1100delC and colorectal cancer. PMID: 14569133 |
Ref: The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe. PMID: 15048074 Ref: Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C. PMID: 15073169 Ref: Possible causes of chromosome instability: comparison of chromosomal abnormalities in cancer cell lines with mutations in BRCA1, BRCA2, CHK2 and BUB1. PMID: 15162061 Ref: Enhanced 7-ethyl-10-hydroxycamptothecin (SN-38) lethality by methylselenocysteine is associated with Chk2 phosphorylation at threonine-68 and down-regulation of Cdc6 expression. PMID: 15213307 Ref: No germline mutations in the histone acetyltransferase gene EP300 in BRCA1 and BRCA2 negative families with breast cancer and gastric, pancreatic, or colorectal cancer. PMID: 15217503 Ref: ATM-dependent CHK2 activation induced by anticancer agent, irofulven. PMID: 15269203 Ref: Chk1, but not Chk2, is involved in the cellular response to DNA damaging agents: differential activity in cells expressing or not p53. PMID: 15326376 Ref: CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses. PMID: 15367709 Ref: 5-fluoro-2'-deoxyuridine-induced cdc25A accumulation correlates with premature mitotic entry and clonogenic death in human colon cancer cells. PMID: 15374972 Ref: Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic catastroph PMID: 15374978 Ref: CHEK2 is a multiorgan cancer susceptibility gene. PMID: 15492928 |
Ref: Homozygosity for a CHEK2*1100delC mutation identified in familial colorectal cancer does not lead to a severe clinical phenotype. PMID: 15818573 Ref: Colorectal cancer and the CHEK2 1100delC mutation. PMID: 15852425 Ref: The CHEK2 1100delC allele is not relevant for risk assessment in HNPCC and HBCC Spanish families. PMID: 15951971 Ref: The p53 pathway is synergized by p38 MAPK signaling to mediate 11,11'-dideoxyverticillin-induced G2/M arrest. PMID: 15963507 |
Ref: p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine. PMID: 16407843 Ref: Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells. PMID: 16456034 Ref: CHEK2 1100delC in patients with metachronous cancers of the breast and the colorectum. PMID: 16539695 Ref: CHEK2 I157T associates with familial and sporadic colorectal cancer. PMID: 16816021 Ref: Low frequency of CHEK2 mutations in familial pancreatic cancer. PMID: 16858628 Ref: Inhibition of colon cancer (HT-29) cell proliferation by a triterpenoid isolated from Azadirachta indica is accompanied by cell cycle arrest and up-regulation of p21. PMID: 16858664 Ref: Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks. PMID: 16905549 Ref: Inherited association of breast and colorectal cancer: limited role of CHEK2 compared with high-penetrance genes. PMID: 17026620 Ref: Genetic and epigenetic analysis of CHEK2 in sporadic breast, colon, and ovarian cancers. PMID: 17145815 Ref: A multicenter study of cancer incidence in CHEK2 1100delC mutation carriers. PMID: 17164383 Ref: The CHEK2 1100delC variant in Swedish colorectal cancer. PMID: 17214356 Ref: Pilot study on low penetrance breast and colorectal cancer predisposition markers in latvia. PMID: 20223004 |
Ref: Increased risk of breast cancer associated with CHEK2*1100delC. PMID: 16880452 Ref: The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase. PMID: 16936775 Ref: Germline CHEK2 mutations and colorectal cancer risk: different effects of a missense and truncating mutations? PMID: 17106448 Ref: Evidence for the receipt of DNA damage stimuli by PML nuclear domains. PMID: 17206596 Ref: Lidamycin induces marked G2 cell cycle arrest in human colon carcinoma HT-29 cells through activation of p38 MAPK pathway. PMID: 17273739 Ref: Epistatic relationship between the cancer susceptibility genes CHEK2 and p27. PMID: 17372254 Ref: Aspirin blocks proliferation in colon cells by inducing a G1 arrest and apoptosis through activation of the checkpoint kinase ATM. PMID: 17510082 Ref: Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library. PMID: 17875720 Ref: Batracylin (NSC 320846), a dual inhibitor of DNA topoisomerases I and II induces histone gamma-H2AX as a biomarker of DNA damage. PMID: 17942930 Ref: Mutation analysis of the checkpoint kinase 2 gene in colorectal cancer cell lines. PMID: 18167186 |
Ref: Constitutional CHEK2 mutations are associated with a decreased risk of lung and laryngeal cancers. PMID: 18281249 Ref: CUGBP2 downregulation by prostaglandin E2 protects colon cancer cells from radiation-induced mitotic catastrophe. PMID: 18325984 Ref: Translation regulatory factor RBM3 is a proto-oncogene that prevents mitotic catastrophe. PMID: 18427544 Ref: Mesalazine negatively regulates CDC25A protein expression and promotes accumulation of colon cancer cells in S phase. PMID: 18495657 Ref: Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins. PMID: 18566216 Ref: Novel evidences for a tumor suppressor role of Rev3, the catalytic subunit of Pol zeta. PMID: 18622427 Ref: Telomere shortening is correlated with the DNA damage response and telomeric protein down-regulation in colorectal preneoplastic lesions. PMID: 18641004 Ref: CHEK2 1100delC is a susceptibility allele for HNPCC-related colorectal cancer. PMID: 18676774 Ref: Alterations of Chk1 and Chk2 expression in colon cancer. PMID: 18679694 |
Ref: The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population. PMID: 18996005 Ref: 1-Methylxanthine enhances the radiosensitivity of tumor cells. PMID: 19280470 Ref: Cancer risks in first-degree relatives of CHEK2 mutation carriers: effects of mutation type and cancer site in proband. PMID: 19401704 Ref: Knockdown of Chk1 sensitizes human colon carcinoma HCT116 cells in a p53-dependent manner to lidamycin through abrogation of a G2/M checkpoint and induction of apoptosis. PMID: 19502782 Ref: Haplotypes of the I157T CHEK2 germline mutation in ethnically diverse populations. PMID: 19609724 Ref: Hypoxia-mediated regulation of Cdc25A phosphatase by p21 and miR-21. PMID: 19738433 Ref: Naphthalimides induce G(2) arrest through the ATM-activated Chk2-executed pathway in HCT116 cells. PMID: 19881958 |
Ref: CHEK2 mutations and HNPCC-related colorectal cancer. PMID: 19876921 Ref: Inhibitors of histone deacetylases suppress cisplatin-induced p53 activation and apoptosis in renal tubular cells. PMID: 19889954 Ref: A new isoquinolinium derivative, Cadein1, preferentially induces apoptosis in p53-defective cancer cells with functional mismatch repair via a p38-dependent pathway. PMID: 19948725 Ref: DNA damage signaling is activated during cancer progression in human colorectal carcinoma. PMID: 20023412 Ref: A role for Chk2 in DNA damage induced mitotic delays in human colorectal cancer cells. PMID: 20023427 Ref: Oxaliplatin responses in colorectal cancer cells are modulated by CHK2 kinase inhibitors. PMID: 20128802 Ref: Enhancement of p53-mutant human colorectal cancer cells radiosensitivity by flavonoid fisetin. PMID: 20637980 Ref: CHEK2 I157T and colorectal cancer in Bulgaria. PMID: 20658728 Ref: Genetic testing and prevention of hereditary cancer at the MMCI--over 10 years of experience. PMID: 21348412 |
Ref: A novel Chk inhibitor, XL-844, increases human cancer cell radiosensitivity through promotion of mitotic catastrophe. PMID: 20024691 Ref: Spatholobus suberectus inhibits cancer cell growth by inducing apoptosis and arresting cell cycle at G2/M checkpoint. PMID: 21073941 Ref: Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. PMID: 21186793 Ref: German national case collection for familial pancreatic cancer (FaPaCa): ten years experience. PMID: 21207249 Ref: Global dissociation of HuR-mRNA complexes promotes cell survival after ionizing radiation. PMID: 21317874 Ref: A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation. PMID: 21338495 Ref: Aflatoxin genotoxicity is associated with a defective DNA damage response bypassing p53 activation. PMID: 21382167 Ref: Phosphorylation of SMC1 by ATR is required for desferrioxamine (DFO)-induced apoptosis. PMID: 21390062 Ref: Priming and potentiation of DNA damage response by fibronectin in human colon cancer cells and tumor-derived myofibroblasts. PMID: 21567080 Ref: 5-Methoxyflavanone induces cell cycle arrest at the G2/M phase, apoptosis and autophagy in HCT116 human colon cancer cells. PMID: 21616090 Ref: DNA damage signaling in response to 5-fluorouracil in three colorectal cancer cell lines with different mismatch repair and TP53 status. PMID: 21674128 Ref: Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells. PMID: 21747117 Ref: Meta-analysis of CHEK2 1100delC variant and colorectal cancer susceptibility. PMID: 21807500 Ref: The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer. PMID: 21860067 Ref: Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing. PMID: 22111927 Ref: Trifluorothymidine exhibits potent antitumor activity via the induction of DNA double-strand breaks. PMID: 22977515 |
Ref: Orphan receptor TR3 participates in cisplatin-induced apoptosis via Chk2 phosphorylation to repress intestinal tumorigenesis. PMID: 22159226 Ref: Potentiation of the novel topoisomerase I inhibitor indenoisoquinoline LMP-400 by the cell checkpoint and Chk1-Chk2 inhibitor AZD7762. PMID: 22189968 Ref: Investigation of the effects of DNA repair gene polymorphisms on the risk of colorectal cancer. PMID: 22294770 Ref: CHEK2 1100delC, IVS2+1G>A and I157T mutations are not present in colorectal cancer cases from Turkish population. PMID: 22521562 Ref: Chk2 phosphorylation of survivin-DeltaEx3 contributes to a DNA damage-sensing checkpoint in cancer. PMID: 22586065 Ref: Multiplexed protein signal pathway mapping identifies patients with rectal cancer that responds to neoadjuvant treatment. PMID: 22658458 Ref: Killing of Kras-mutant colon cancer cells via Rac-independent actin remodeling by the betaGBP cytokine, a physiological PI3K inhibitor therapeutically effective in vivo. PMID: 22752425 Ref: The CHEK2 I157T variant and colorectal cancer susceptibility: a systematic review and meta-analysis. PMID: 22901170 Ref: CHEK2 1100DELC germline mutation: a frequency study in hereditary breast and colon cancer Brazilian families. PMID: 23329222 |
Ref: Acquired irinotecan resistance is accompanied by stable modifications of cell cycle dynamics independent of MSI status. PMID: 23546019 Ref: Cell cycle-dependent localization of CHK2 at centrosomes during mitosis. PMID: 23680298 Ref: The effect of CHEK2 variant I157T on cancer susceptibility: evidence from a meta-analysis. PMID: 23713947 Ref: MSH3 mismatch repair protein regulates sensitivity to cytotoxic drugs and a histone deacetylase inhibitor in human colon carcinoma cells. PMID: 23724141 Ref: Development of a new, simple and cost-effective diagnostic tool for genetic screening of hereditary colorectal cancer--the DNA microarray assay. PMID: 23741719 Ref: HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. PMID: 23770684 Ref: Genistein-induced G2/M cell cycle arrest of human intestinal colon cancer Caco-2 cells is associated with Cyclin B1 and Chk2 down-regulation. PMID: 23794041 Ref: Anticancer effect of Tamarix gallica extracts on human colon cancer cells involves Erk1/2 and p38 action on G2/M cell cycle arrest. PMID: 23801270 Ref: N-Hydroxycinnamide derivatives of osthole presenting genotoxicity and cytotoxicity against human colon adenocarcinoma cells in vitro and in vivo. PMID: 24127835 Ref: Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRgamma activation. PMID: 24190430 Ref: In Vitro Antiproliferative Effect of Arthrocnemum indicum Extracts on Caco-2 Cancer Cells through Cell Cycle Control and Related Phenol LC-TOF-MS Identification. PMID: 24348703 |
Ref: Genetic variants associated with colorectal cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence. PMID: 23946381 Ref: Panel-based testing for inherited colorectal cancer: a descriptive study of clinical testing performed by a US laboratory. PMID: 24506336 Ref: Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells. PMID: 24858802 Ref: HuR regulates alternative splicing of the TRA2beta gene in human colon cancer cells under oxidative stress. PMID: 24865968 Ref: Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells. PMID: 24976383 Ref: SKLB316, a novel small-molecule inhibitor of cell-cycle progression, induces G2/M phase arrest and apoptosis in vitro and inhibits tumor growth in vivo. PMID: 25301449 Ref: Distinct DNA damage determines differential phosphorylation of Chk2. PMID: 25535901 Ref: [Genotyping of BRCA1, BRCA2 and CHEK2 germline mutations in Russian breast cancer patients using diagnostic biochips]. PMID: 25850293 |
Ref: P53 deficiency-induced Smad1 upregulation suppresses tumorigenesis and causes chemoresistance in colorectal cancers. PMID: 25757624 Ref: Expression of DNA damage checkpoint 53BP1 is correlated with prognosis, cell proliferation and apoptosis in colorectal cancer. PMID: 26261485 Ref: Targeting SOD1 induces synthetic lethal killing in BLM- and CHEK2-deficient colorectal cancer cells. PMID: 26318585 Ref: Identification of novel, in vivo active Chk1 inhibitors utilizing structure guided drug design. PMID: 26437226 Ref: Erratum: CHEK2 1100DELC germline mutation: a frequency study in hereditary breast and colon cancer Brazilian families. PMID: 26498296 Ref: Antitumor Activity of Americanin A Isolated from the Seeds of Phytolacca americana by Regulating the ATM/ATR Signaling Pathway and the Skp2-p27 Axis in Human Colon Cancer Cells. PMID: 26595875 Ref: Circadian gene expression predicts patient response to neoadjuvant chemoradiation therapy for rectal cancer. PMID: 26617816 Ref: The CHEK2 del5395 is a founder mutation without direct effects for cancer risk in the latvian population. PMID: 27785394 |
Ref: The putative oncogene CEP72 inhibits the mitotic function of BRCA1 and induces chromosomal instability. PMID: 26300001 Ref: ROBO1 deletion as a novel germline alteration in breast and colorectal cancer patients. PMID: 26427657 Ref: Contribution of rare germline copy number variations and common susceptibility loci in Lynch syndrome patients negative for mutations in the mismatch repair genes. PMID: 26620301 Ref: Mus81 knockdown improves chemosensitivity of hepatocellular carcinoma cells by inducing S-phase arrest and promoting apoptosis through CHK1 pathway. PMID: 26714930 Ref: The downregulation of the RNA-binding protein Staufen2 in response to DNA damage promotes apoptosis. PMID: 26843428 Ref: Screening for germline BRCA1, BRCA2, TP53 and CHEK2 mutations in families at-risk for hereditary breast cancer identified in a population-based study from Southern Brazil. PMID: 27223485 Ref: A Novel Chemotherapeutic Agent to Treat Tumors with DNA Mismatch Repair Deficiencies. PMID: 27262172 Ref: Deficiency of 53BP1 inhibits the radiosensitivity of colorectal cancer. PMID: 27499037 Ref: Prevalence of the CHEK2 R95* germline mutation. PMID: 27708748 Ref: Homozygous inactivation of CHEK2 is linked to a familial case of multiple primary lung cancer with accompanying cancers in other organs. PMID: 27900359 |
Ref: Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer. PMID: 27978560 Ref: Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer. PMID: 28135145 Ref: High-risk epithelial ovarian cancer patients for hereditary ovarian cancer. PMID: 28188963 Ref: Neural precursor cell expressed, developmentally downregulated 8activating enzyme inhibitor MLN4924 sensitizes colorectal cancer cells to oxaliplatin by inducing DNA damage, G2 cell cycle arrest and apoptosis. PMID: 28447739 Ref: Mucin 2 silencing promotes colon cancer metastasis through interleukin-6 signaling. PMID: 28725043 Ref: Colorectal cancer risk associated with the CHEK2 1100delC variant. PMID: 28734145 Ref: Regiospecific Synthesis of Ring A Fused Withaferin A Isoxazoline Analogues: Induction of Premature Senescence by W-2b in Proliferating Cancer Cells. PMID: 29062040 Ref: XRRA1 Targets ATM/CHK1/2-Mediated DNA Repair in Colorectal Cancer. PMID: 29082250 Ref: Targeted sequencing of established and candidate colorectal cancer genes in the Colon Cancer Family Registry Cohort. PMID: 29212164 |
Ref: AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11. PMID: 28967905 Ref: Germline Genetic Features of Young Individuals With Colorectal Cancer. PMID: 29146522 Ref: Insight into the role of PIKK family members and NF-small ka, CyrillicB in DNAdamage-induced senescence and senescence-associated secretory phenotype of colon cancer cells. PMID: 29352261 Ref: 53BP1 loss suppresses the radiosensitizing effect of icotinib hydrochloride in colorectal cancer cells. PMID: 29388453 Ref: Spectrum of APC and MUTYH germ-line mutations in Russian patients with colorectal malignancies. PMID: 29406563 Ref: Identification of genetic variants for clinical management of familial colorectal tumors. PMID: 29458332 Ref: Riluzole Inhibits Proliferation, Migration and Cell Cycle Progression and Induces Apoptosis in Tumor Cells of Various Origins. PMID: 29493465 Ref: Overexpression of Nitrogen Permease Regulator Like-2 (NPRL2) Enhances Sensitivity to Irinotecan (CPT-11) in Colon Cancer Cells by Activating the DNA Damage Checkpoint Pathway. PMID: 29519997 Ref: shRNAinduced knockdown of the SPERT gene inhibits proliferation and promotes apoptosis of human colorectal cancer RKO cells. PMID: 29845259 Ref: The expression of telomere-related proteins and DNA damage response and their association with telomere length in colorectal cancer in Saudi patients. PMID: 29870526 Ref: A452, an HDAC6-selective inhibitor, synergistically enhances the anticancer activity of chemotherapeutic agents in colorectal cancer cells. PMID: 29917295 Ref: Association of genetic variants in ATR-CHEK1 and ATM-CHEK2 pathway genes with risk of colorectal cancer in a Chinese population. PMID: 29928473 Ref: MicroRNA expression profiles identify biomarkers for predicting the response to chemoradiotherapy in rectal cancer. PMID: 29956755 Ref: Chaetominine induces cell cycle arrest in human leukemia K562 and colon cancer SW1116 cells. PMID: 30214601 Ref: Novel genetic mutations detected by multigene panel are associated with hereditary colorectal cancer predisposition. PMID: 30256826 Ref: Expression levels of hnRNP K and p21WAF1/CIP1 are associated with resistance to radiochemotherapy independent of p53 pathway activation in rectal adenocarcinoma. PMID: 30272263 Ref: Cytoplasmic p21 Mediates 5-Fluorouracil Resistance by Inhibiting Pro-Apoptotic Chk2. PMID: 30304835 |