Literatures

Primary Site >> Colorectal Cancer

Gene >> CHEK1

1.
Journal:	Genes Chromosomes Cancer. 1999 Oct;26(2):176-80.
Title:	CHK1 frameshift mutations in genetically unstable colorectal and endometrial cancers.
Author:	Bertoni, F\|Codegoni, A M\|Furlan, D\|Tibiletti, M G\|Capella, C\|Broggini, M
PMID:	10469457

2.
Journal:	Curr Pharm Des. 2000 Mar;6(4):379-92.
Title:	Cell cycle molecular targets in novel anticancer drug discovery.
Author:	Buolamwini, J K
PMID:	10788588

3.
Journal:	Oncogene. 2000 Dec 27;19(56):6600-6.
Title:	Small molecule modulators of cyclin-dependent kinases for cancer therapy.
Author:	Senderowicz, A M
PMID:	11426645

4.
Journal:	Cancer Res. 2002 Oct 15;62(20):5743-8.
Title:	UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1.
Author:	Yu, Qiang\|La Rose, JiHyun\|Zhang, Hongliang\|Takemura, Haruyuki\|Kohn, Kurt W\|Pommier, Yves
PMID:	12384533

5.
Journal:	Oncogene. 2003 Apr 10;22(14):2110-20.
Title:	The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase.
Author:	Franchitto, Annapaola\|Pichierri, Pietro\|Piergentili, Rita\|Crescenzi, Marco\|Bignami, Margherita\|Palitti, Fabrizio
PMID:	12687013

6.
Journal:	J Biol Chem. 2004 May 14;279(20):21183-92.
Title:	p53-regulated transcriptional program associated with genotoxic stress-induced apoptosis.
Author:	Kho, Patricia S\|Wang, Zhen\|Zhuang, Li\|Li, Yuqing\|Chew, Joon-Lin\|Ng, Huck-Hui\|Liu, Edison T\|Yu, Qiang
PMID:	15016801

7.
Journal:	Oncogene. 2004 May 27;23(25):4353-61.
Title:	The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe.
Author:	Castedo, Maria\|Perfettini, Jean-Luc\|Roumier, Thomas\|Yakushijin, Kenichi\|Horne, David\|Medema, Rene\|Kroemer, Guido
PMID:	15048074

8.
Journal:	Acta Pharmacol Sin. 2004 Jun;25(6):756-62.
Title:	Abrogation of Chk1-mediated S/G2 checkpoint by UCN-01 enhances ara-C-induced cytotoxicity in human colon cancer cells.
Author:	Shao, Rong-Guang\|Cao, Chun-Xia\|Pommier, Yves
PMID:	15169628

9.
Journal:	Mol Pharmacol. 2004 Jul;66(1):153-60.
Title:	Enhanced 7-ethyl-10-hydroxycamptothecin (SN-38) lethality by methylselenocysteine is associated with Chk2 phosphorylation at threonine-68 and down-regulation of Cdc6 expression.
Author:	Yin, Ming-Biao\|Li, Zhan-Rong\|Cao, Shousong\|Durrani, Farukh A\|Azrak, Rami G\|Frank, Cheryl\|Rustum, Youcef M
PMID:	15213307

10.
Journal:	J Biol Chem. 2004 Sep 17;279(38):39584-92. Epub 2004 Jul 20.
Title:	ATM-dependent CHK2 activation induced by anticancer agent, irofulven.
Author:	Wang, Jian\|Wiltshire, Timothy\|Wang, Yutian\|Mikell, Carmenza\|Burks, Julian\|Cunningham, Cynthia\|Van Laar, Emily S\|Waters, Stephen J\|Reed, Eddie\|Wang, Weixin
PMID:	15269203

11.
Journal:	EMBO J. 2004 Aug 4;23(15):3164-74. Epub 2004 Jul 29.
Title:	ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background.
Author:	Fang, Yanan\|Tsao, Cheng-Chung\|Goodman, Barbara K\|Furumai, Ryohei\|Tirado, Carlos A\|Abraham, Robert T\|Wang, Xiao-Fan
PMID:	15282542

12.
Journal:	Cell Cycle. 2004 Sep;3(9):1177-81. Epub 2004 Sep 13.
Title:	Chk1, but not Chk2, is involved in the cellular response to DNA damaging agents: differential activity in cells expressing or not p53.
Author:	Carrassa, Laura\|Broggini, Massimo\|Erba, Eugenio\|Damia, Giovanna
PMID:	15326376

13.
Journal:	Mol Cancer Ther. 2004 Sep;3(9):1147-57.
Title:	CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses.
Author:	Yan, Tao\|Desai, Anand B\|Jacobberger, James W\|Sramkoski, R Michael\|Loh, Tamalette\|Kinsella, Timothy J
PMID:	15367709

14.
Journal:	Cancer Res. 2004 Sep 15;64(18):6588-94.
Title:	5-fluoro-2'-deoxyuridine-induced cdc25A accumulation correlates with premature mitotic entry and clonogenic death in human colon cancer cells.
Author:	Parsels, Leslie Anne\|Parsels, Joshua David\|Tai, Daniel Chung-Ho\|Coughlin, Daniel James\|Maybaum, Jonathan
PMID:	15374972

15.
Journal:	Cancer Res. 2004 Sep 15;64(18):6635-44.
Title:	Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic catastroph
Author:	Tse, Archie N\|Schwartz, Gary K
PMID:	15374978

16.
Journal:	Oncogene. 2006 May 11;25(20):2839-49.
Title:	p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.
Author:	Furuta, T\|Hayward, R L\|Meng, L-H\|Takemura, H\|Aune, G J\|Bonner, W M\|Aladjem, M I\|Kohn, K W\|Pommier, Y
PMID:	16407843

17.
Journal:	Nucleic Acids Res. 2006 Feb 2;34(3):880-92. Print 2006.
Title:	Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells.
Author:	Hiyama, Takashi\|Katsura, Mari\|Yoshihara, Takashi\|Ishida, Mari\|Kinomura, Aiko\|Tonda, Tetsuji\|Asahara, Toshimasa\|Miyagawa, Kiyoshi
PMID:	16456034

18.
Journal:	Mol Carcinog. 2006 Jul;45(7):461-78.
Title:	Checkpoint kinase 1-mediated phosphorylation of Cdc25C and bad proteins are involved in antitumor effects of loratadine-induced G2/M phase cell-cycle arrest and apoptosis.
Author:	Chen, Jinn-Shiun\|Lin, Shyr-Yi\|Tso, Wei-Ling\|Yeh, Geng-Chang\|Lee, Wen-Sen\|Tseng, How\|Chen, Li-Ching\|Ho, Yuan-Soon
PMID:	16649252

19.
Journal:	Bioorg Med Chem. 2006 Nov 15;14(22):7551-62.
Title:	Synthesis and biological activities of 7-aza rebeccamycin analogues bearing the sugar moiety on the nitrogen of the pyridine ring.
Author:	Messaoudi, Samir\|Anizon, Fabrice\|Peixoto, Paul\|David-Cordonnier, Marie-Helene\|Golsteyn, Roy M\|Leonce, Stephane\|Pfeiffer, Bruno\|Prudhomme, Michelle
PMID:	16889964

20.
Journal:	J Biol Chem. 2006 Oct 13;281(41):30814-23. Epub 2006 Aug 10.
Title:	Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.
Author:	Takemura, Haruyuki\|Rao, V Ashutosh\|Sordet, Olivier\|Furuta, Takahisa\|Miao, Ze-Hong\|Meng, Linghua\|Zhang, Hongliang\|Pommier, Yves
PMID:	16905549

21.
Journal:	Eur J Med Chem. 2006 Dec;41(12):1470-7. Epub 2006 Sep 22.
Title:	Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of indolylpyrazolones and indolylpyridazinedione.
Author:	Conchon, Elisabeth\|Aboab, Bettina\|Golsteyn, Roy M\|Cruzalegui, Francisco\|Edmonds, Thomas\|Leonce, Stephane\|Pfeiffer, Bruno\|Prudhomme, Michelle
PMID:	16996169

22.
Journal:	Anticancer Drugs. 2006 Nov;17(10):1171-7.
Title:	The DNA damage checkpoint is activated during residual tumour cell survival to methotrexate treatment as an initial step of acquired drug resistance.
Author:	de Anta, Josep M\|Perez-Castro, Antonio J\|Freire, Raimundo\|Mayol, Xavier
PMID:	17075316

23.
Journal:	Biochem Pharmacol. 2007 Mar 15;73(6):760-72.
Title:	Excess ribonucleotide reductase R2 subunits coordinate the S phase checkpoint to facilitate DNA damage repair and recovery from replication stress.
Author:	Lin, Z Ping\|Belcourt, Michael F\|Carbone, Rocco\|Eaton, Jana S\|Penketh, Philip G\|Shadel, Gerald S\|Cory, Joseph G\|Sartorelli, Alan C
PMID:	17188250

24.
Journal:	Gastroenterology. 2007 Jan;132(1):221-35.
Title:	5-ASA affects cell cycle progression in colorectal cells by reversibly activating a replication checkpoint.
Author:	Luciani, M Gloria\|Campregher, Christoph\|Fortune, John M\|Kunkel, Thomas A\|Gasche, Christoph
PMID:	17241873

25.
Journal:	Oncol Rep. 2007 Mar;17(3):597-603.
Title:	Lidamycin induces marked G2 cell cycle arrest in human colon carcinoma HT-29 cells through activation of p38 MAPK pathway.
Author:	Liu, Xia\|Bian, Chunjing\|Ren, Kaihuan\|Jin, Haixia\|Li, Baowei\|Shao, Rong-Guang
PMID:	17273739

26.
Journal:	Food Chem Toxicol. 2007 Aug;45(8):1356-67. Epub 2007 Jan 24.
Title:	Tubulozole-induced G2/M cell cycle arrest in human colon cancer cells through formation of microtubule polymerization mediated by ERK1/2 and Chk1 kinase activation.
Author:	Chou, Yean-Hwei\|Ho, Yuan-Soon\|Wu, Chi-Chen\|Chai, Chiah-Yang\|Chen, Soul-Chin\|Lee, Chia-Hwa\|Tsai, Pei-Shan\|Wu, Chih-Hsiung
PMID:	17329004

27.
Journal:	Eur J Surg Oncol. 2007 Jun;33(5):580-5. Epub 2007 Apr 3.
Title:	Chk1 frameshift mutation in sporadic and hereditary non-polyposis colorectal cancers with microsatellite instability.
Author:	Kim, C J\|Lee, J H\|Song, J W\|Cho, Y G\|Kim, S Y\|Nam, S W\|Yoo, N J\|Park, W S\|Lee, J Y
PMID:	17408908

28.
Journal:	Mol Cell Biol. 2007 Aug;27(16):5806-18.
Title:	The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses.
Author:	Seiler, Jennifer A\|Conti, Chiara\|Syed, Ali\|Aladjem, Mirit I\|Pommier, Yves
PMID:	17515603

29.
Journal:	Bioorg Med Chem. 2007 Sep 1;15(17):5965-80.
Title:	Synthesis and biological activities of isogranulatimide analogues.
Author:	Hugon, Bernadette\|Anizon, Fabrice\|Bailly, Christian\|Golsteyn, Roy M\|Pierre, Alain\|Leonce, Stephane\|Hickman, John\|Pfeiffer, Bruno\|Prudhomme, Michelle
PMID:	17582773

30.
Journal:	J Med Chem. 2007 Sep 20;50(19):4669-80.
Title:	Synthesis and biological activities of new checkpoint kinase 1 inhibitors structurally related to granulatimide.
Author:	Conchon, Elisabeth\|Anizon, Fabrice\|Aboab, Bettina\|Prudhomme, Michelle
PMID:	17722905

31.
Journal:	Mol Cell Proteomics. 2007 Dec;6(12):2150-64.
Title:	A proteomics analysis of cell signaling alterations in colorectal cancer.
Author:	Madoz-Gurpide, Juan\|Canamero, Marta\|Sanchez, Lydia\|Solano, Jose\|Alfonso, Patricia\|Casal, J Ignacio
PMID:	17848589

32.
Journal:	Cell Cycle. 2007 Nov 15;6(22):2760-7. Epub 2007 Aug 22.
Title:	The mammalian DNA replication elongation checkpoint: implication of Chk1 and relationship with origin firing as determined by single DNA molecule and single cell analyses.
Author:	Conti, Chiara\|Seiler, Jennifer A\|Pommier, Yves
PMID:	17986860

33.
Journal:	PLoS One. 2007 Dec 26;2(12):e1337.
Title:	Inhibition of Chk1 kills tetraploid tumor cells through a p53-dependent pathway.
Author:	Vitale, Ilio\|Galluzzi, Lorenzo\|Vivet, Sonia\|Nanty, Lisa\|Dessen, Philippe\|Senovilla, Laura\|Olaussen, Ken A\|Lazar, Vladimir\|Prudhomme, Michelle\|Golsteyn, Roy M\|Castedo, Maria\|Kroemer, Guido
PMID:	18159231

34.
Journal:	Eur J Med Chem. 2008 Feb;43(2):282-92.
Title:	Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of pyrrolo[3,4-a]carbazole-1,3-diones, pyrrolo[3,4-c]carbazole-1,3-diones, and 2-aminopyridazino[3,4-a]pyrrolo[3,4-c]carbazole-1,3,4,7-tetraone.
Author:	Conchon, Elisabeth\|Anizon, Fabrice\|Aboab, Bettina\|Golsteyn, Roy M\|Leonce, Stephane\|Pfeiffer, Bruno\|Prudhomme, Michelle
PMID:	17502122

35.
Journal:	Gut. 2008 Jun;57(6):780-7.
Title:	Activated neutrophils induce an hMSH2-dependent G2/M checkpoint arrest and replication errors at a (CA)13-repeat in colon epithelial cells.
Author:	Campregher, C\|Luciani, M G\|Gasche, C
PMID:	18272544

36.
Journal:	Bioorg Med Chem. 2008 Apr 15;16(8):4419-30.
Title:	Synthesis, checkpoint kinase 1 inhibitory properties and in vitro antiproliferative activities of new pyrrolocarbazoles.
Author:	Conchon, Elisabeth\|Anizon, Fabrice\|Aboab, Bettina\|Golsteyn, Roy M\|Leonce, Stephane\|Pfeiffer, Bruno\|Prudhomme, Michelle
PMID:	18321713

37.
Journal:	Am J Physiol Gastrointest Liver Physiol. 2008 May;294(5):G1235-44.
Title:	CUGBP2 downregulation by prostaglandin E2 protects colon cancer cells from radiation-induced mitotic catastrophe.
Author:	Natarajan, Gopalan\|Ramalingam, Satish\|Ramachandran, Ilangovan\|May, Randal\|Queimado, Lurdes\|Houchen, Courtney W\|Anant, Shrikant
PMID:	18325984

38.
Journal:	Oncogene. 2008 Jul 31;27(33):4544-56.
Title:	Translation regulatory factor RBM3 is a proto-oncogene that prevents mitotic catastrophe.
Author:	Sureban, S M\|Ramalingam, S\|Natarajan, G\|May, R\|Subramaniam, D\|Bishnupuri, K S\|Morrison, A R\|Dieckgraefe, B K\|Brackett, D J\|Postier, R G\|Houchen, C W\|Anant, S
PMID:	18427544

39.
Journal:	J Biol Chem. 2008 Aug 1;283(31):21382-93.
Title:	Role of c-Abl kinase in DNA mismatch repair-dependent G2 cell cycle checkpoint arrest responses.
Author:	Wagner, Mark W\|Li, Long Shan\|Morales, Julio C\|Galindo, Cristi L\|Garner, Harold R\|Bornmann, William G\|Boothman, David A
PMID:	18480061

40.
Journal:	Carcinogenesis. 2008 Jun;29(6):1258-66.
Title:	Mesalazine negatively regulates CDC25A protein expression and promotes accumulation of colon cancer cells in S phase.
Author:	Stolfi, Carmine\|Fina, Daniele\|Caruso, Roberta\|Caprioli, Flavio\|Fantini, Massimo Claudio\|Rizzo, Angelamaria\|Sarra, Massimiliano\|Pallone, Francesco\|Monteleone, Giovanni
PMID:	18495657

41.
Journal:	Oncogene. 2008 Sep 18;27(42):5567-77.
Title:	Geldanamycin promotes premature mitotic entry and micronucleation in irradiated p53/p21 deficient colon carcinoma cells.
Author:	Moran, D M\|Gawlak, G\|Jayaprakash, M S\|Mayar, S\|Maki, C G
PMID:	18504430

42.
Journal:	Mol Cancer Ther. 2008 Jun;7(6):1440-9.
Title:	Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins.
Author:	Huang, Min\|Miao, Ze-Hong\|Zhu, Hong\|Cai, Yu-Jun\|Lu, Wei\|Ding, Jian
PMID:	18566216

43.
Journal:	Cancer Res. 2008 Jul 15;68(14):5609-18.
Title:	Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells.
Author:	Gali-Muhtasib, Hala\|Kuester, Doerthe\|Mawrin, Christian\|Bajbouj, Khuloud\|Diestel, Antje\|Ocker, Matthias\|Habold, Caroline\|Foltzer-Jourdainne, Charlotte\|Schoenfeld, Peter\|Peters, Brigitte\|Diab-Assaf, Mona\|Pommrich, Ulf\|Itani, Wafica\|Lippert, Hans\|Roessner, A
PMID:	18632613

44.
Journal:	Biomarkers. 2008 Sep;13(6):579-96.
Title:	Cyclin B1 is an efficacy-predicting biomarker for Chk1 inhibitors.
Author:	Xiao, Zhan\|Xue, John\|Gu, Wen-Zhen\|Bui, Mai\|Li, Gaoquan\|Tao, Zhi-Fu\|Lin, Nan-Horng\|Sowin, Thomas J\|Zhang, Haiying
PMID:	18671143

45.
Journal:	Int J Colorectal Dis. 2008 Dec;23(12):1243-9.
Title:	Alterations of Chk1 and Chk2 expression in colon cancer.
Author:	Stawinska, Magdalena\|Cygankiewicz, Adam\|Trzcinski, Radzislaw\|Mik, Michal\|Dziki, Adam\|Krajewska, Wanda M
PMID:	18679694

46.
Journal:	Mol Pharmacol. 2009 Jan;75(1):124-33.
Title:	90-kDa heat shock protein inhibition abrogates the topoisomerase I poison-induced G2/M checkpoint in p53-null tumor cells by depleting Chk1 and Wee1.
Author:	Tse, Archie N\|Sheikh, Tahir N\|Alan, Ho\|Chou, Ting-Chao\|Schwartz, Gary K
PMID:	18820127

47.
Journal:	Int J Cancer. 2009 Jun 15;124(12):2797-803.
Title:	Ascochlorin activates p53 in a manner distinct from DNA damaging agents.
Author:	Jeong, Ji-Hak\|Nakajima, Hiroo\|Magae, Junji\|Furukawa, Chiharu\|Taki, Keiko\|Otsuka, Kensuke\|Tomita, Masanori\|Lee, In-Seon\|Kim, Cheorl-Ho\|Chang, Hyeun-Wook\|Min, Kwan-Sik\|Park, Kwang-Kyun\|Park, Kwan-Kyu\|Chang, Young-Chae
PMID:	19253369

48.
Journal:	Int J Cancer. 2009 Sep 1;125(5):996-1003.
Title:	Rimonabant inhibits human colon cancer cell growth and reduces the formation of precancerous lesions in the mouse colon.
Author:	Santoro, Antonietta\|Pisanti, Simona\|Grimaldi, Claudia\|Izzo, Angelo A\|Borrelli, Francesca\|Proto, Maria C\|Malfitano, Anna M\|Gazzerro, Patrizia\|Laezza, Chiara\|Bifulco, Maurizio
PMID:	19479993

49.
Journal:	Cancer Biol Ther. 2009 Aug;8(16):1559-66. Epub 2009 Aug 8.
Title:	Knockdown of Chk1 sensitizes human colon carcinoma HCT116 cells in a p53-dependent manner to lidamycin through abrogation of a G2/M checkpoint and induction of apoptosis.
Author:	Pan, Yu\|Ren, Kai-Huan\|He, Hong-Wei\|Shao, Rong-Guang
PMID:	19502782

50.
Journal:	Mol Biol Cell. 2009 Sep;20(17):3801-9.
Title:	Reduced ATR or Chk1 expression leads to chromosome instability and chemosensitization of mismatch repair-deficient colorectal cancer cells.
Author:	Jardim, Melanie J\|Wang, Qinhong\|Furumai, Ryohei\|Wakeman, Timothy\|Goodman, Barbara K\|Wang, Xiao-Fan
PMID:	19570909

51.
Journal:	Cell Cycle. 2009 Oct 1;8(19):3157-64. Epub 2009 Oct 3.
Title:	Hypoxia-mediated regulation of Cdc25A phosphatase by p21 and miR-21.
Author:	de Oliveira, Pierre E Queiroz\|Zhang, Lin\|Wang, Zhenghe\|Lazo, John S
PMID:	19738433

52.
Journal:	Neoplasia. 2009 Nov;11(11):1226-34.
Title:	Naphthalimides induce G(2) arrest through the ATM-activated Chk2-executed pathway in HCT116 cells.
Author:	Zhu, Hong\|Miao, Ze-Hong\|Huang, Min\|Feng, Jian-Ming\|Zhang, Zhi-Xiang\|Lu, Jin-Jian\|Cai, Yu-Jun\|Tong, Lin-Jiang\|Xu, Yu-Fang\|Qian, Xu-Hong\|Ding, Jian
PMID:	19881958

53.
Journal:	Int J Biochem Cell Biol. 2010 Feb;42(2):318-28.
Title:	Checkpoint kinase 1 modulates sensitivity to cisplatin after spindle checkpoint activation in SW620 cells.
Author:	Peralta-Sastre, A\|Manguan-Garcia, C\|de Luis, A\|Belda-Iniesta, C\|Moreno, S\|Perona, R\|Sanchez-Perez, I
PMID:	19931410

54.
Journal:	Cell Cycle. 2010 Jan 15;9(2):312-20. Epub 2010 Jan 23.
Title:	A role for Chk2 in DNA damage induced mitotic delays in human colorectal cancer cells.
Author:	Varmark, Hanne\|Kwak, Seongae\|Theurkauf, William E
PMID:	20023427

55.
Journal:	Mol Cancer Ther. 2010 Jan;9(1):89-100.
Title:	The preclinical pharmacology and therapeutic activity of the novel CHK1 inhibitor SAR-020106.
Author:	Walton, Michael I\|Eve, Paul D\|Hayes, Angela\|Valenti, Melanie\|De Haven Brandon, Alexis\|Box, Gary\|Boxall, Kathy J\|Aherne, G Wynne\|Eccles, Suzanne A\|Raynaud, Florence I\|Williams, David H\|Reader, John C\|Collins, Ian\|Garrett, Michelle D
PMID:	20053762

56.
Journal:	Cell Cycle. 2010 Feb 1;9(3):450-5. Epub 2010 Feb 3.
Title:	NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling.
Author:	Sorensen, Claus Storgaard\|Melixetian, Marina\|Klein, Ditte Kjaersgaard\|Helin, Kristian
PMID:	20090422

57.
Journal:	Radiat Oncol. 2010 Feb 3;5:8.
Title:	Loratadine dysregulates cell cycle progression and enhances the effect of radiation in human tumor cell lines.
Author:	Soule, Benjamin P\|Simone, Nicole L\|DeGraff, William G\|Choudhuri, Rajani\|Cook, John A\|Mitchell, James B
PMID:	20128919

58.
Journal:	Cell Prolif. 2010 Aug;43(4):365-71.
Title:	p53-dependent G(1) arrest in 1st or 2nd cell cycle may protect human cancer cells from cell death after treatment with ionizing radiation and Chk1 inhibitors.
Author:	Petersen, L\|Hasvold, G\|Lukas, J\|Bartek, J\|Syljuasen, R G
PMID:	20590661

59.
Journal:	Oncol Rep. 2010 Oct;24(4):1029-34.
Title:	Possibility of paclitaxel as an alternative radiosensitizer to 5-fluorouracil for colon cancer.
Author:	Hiro, Junichiro\|Inoue, Yasuhiro\|Toiyama, Yuji\|Yoshiyama, Shigeyuki\|Tanaka, Koji\|Mohri, Yasuhiko\|Miki, Chikao\|Kusunoki, Masato
PMID:	20811685

60.
Journal:	Invest New Drugs. 2011 Jun;29(3):514-22.
Title:	A novel Chk inhibitor, XL-844, increases human cancer cell radiosensitivity through promotion of mitotic catastrophe.
Author:	Riesterer, Oliver\|Matsumoto, Fumihiko\|Wang, Li\|Pickett, Jessica\|Molkentine, David\|Giri, Uma\|Milas, Luka\|Raju, Uma
PMID:	20024691

61.
Journal:	J Cell Mol Med. 2011 Jul;15(7):1528-41.
Title:	Cutting edge: Chk1 directs senescence and mitotic catastrophe in recovery from G(2) checkpoint arrest.
Author:	Poehlmann, Angela\|Habold, Caroline\|Walluscheck, Diana\|Reissig, Kathrin\|Bajbouj, Khuloud\|Ullrich, Oliver\|Hartig, Roland\|Gali-Muhtasib, Hala\|Diestel, Antje\|Roessner, Albert\|Schneider-Stock, Regine
PMID:	20716119

62.
Journal:	J Ethnopharmacol. 2011 Jan 27;133(2):751-8.
Title:	Spatholobus suberectus inhibits cancer cell growth by inducing apoptosis and arresting cell cycle at G2/M checkpoint.
Author:	Wang, Zhi-Yu\|Wang, Dong-Mei\|Loo, Tjing Yung\|Cheng, Yue\|Chen, Lei-Lei\|Shen, Jian-Gang\|Yang, De-Po\|Chow, Louis Wing-Cheong\|Guan, Xin-Yuan\|Chen, Jian-Ping
PMID:	21073941

63.
Journal:	J Med Chem. 2011 Jan 27;54(2):580-90.
Title:	Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2.
Author:	Caldwell, John J\|Welsh, Emma J\|Matijssen, Cornelis\|Anderson, Victoria E\|Antoni, Laurent\|Boxall, Kathy\|Urban, Frederique\|Hayes, Angela\|Raynaud, Florence I\|Rigoreau, Laurent J M\|Raynham, Tony\|Aherne, G Wynne\|Pearl, Laurence H\|Oliver, Antony W\|Garrett, Miche
PMID:	21186793

64.
Journal:	Int J Oncol. 2011 Apr;38(4):1067-73.
Title:	Cantharidin induces G2/M phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of CDK1 activity and caspase-dependent signaling pathways.
Author:	Huang, Wen-Wen\|Ko, Shih-Wei\|Tsai, Huei-Yann\|Chung, Jing-Gung\|Chiang, Jo-Hua\|Chen, Kuan-Tin\|Chen, Yen-Chen\|Chen, Hung-Yi\|Chen, Yuh-Fung\|Yang, Jai-Sing
PMID:	21271215

65.
Journal:	Stem Cells. 2011 Mar;29(3):418-29.
Title:	Inhibition of ataxia telangiectasia- and Rad3-related function abrogates the in vitro and in vivo tumorigenicity of human colon cancer cells through depletion of the CD133(+) tumor-initiating cell fraction.
Author:	Gallmeier, Eike\|Hermann, Patrick C\|Mueller, Maria-Theresa\|Machado, Juan G\|Ziesch, Andreas\|De Toni, Enrico N\|Palagyi, Andreas\|Eisen, Christian\|Ellwart, Joachim W\|Rivera, Jose\|Rubio-Viqueira, Belen\|Hidalgo, Manuel\|Bunz, Fred\|Goke, Burkhard\|Heeschen, Christo
PMID:	21308861

66.
Journal:	Liver Int. 2011 Apr;31(4):561-71.
Title:	Aflatoxin genotoxicity is associated with a defective DNA damage response bypassing p53 activation.
Author:	Gursoy-Yuzugullu, Ozge\|Yuzugullu, Haluk\|Yilmaz, Mustafa\|Ozturk, Mehmet
PMID:	21382167

67.
Journal:	Cell Death Dis. 2011 Mar 10;2:e128.
Title:	Phosphorylation of SMC1 by ATR is required for desferrioxamine (DFO)-induced apoptosis.
Author:	So, E Y\|Ausman, M\|Saeki, T\|Ouchi, T
PMID:	21390062

68.
Journal:	Int J Biochem Cell Biol. 2011 Sep;43(9):1354-64.
Title:	Adenomatous polyposis coli protein regulates the cellular response to DNA replication stress.
Author:	Brocardo, Mariana G\|Borowiec, James A\|Henderson, Beric R
PMID:	21664290

69.
Journal:	Int J Oncol. 2011 Sep;39(3):673-82.
Title:	DNA damage signaling in response to 5-fluorouracil in three colorectal cancer cell lines with different mismatch repair and TP53 status.
Author:	Adamsen, Birgitte L\|Kravik, Katherine L\|De Angelis, Paula M
PMID:	21674128

70.
Journal:	BMC Genomics. 2011 Oct 14;12:505.
Title:	Tumor-specific usage of alternative transcription start sites in colorectal cancer identified by genome-wide exon array analysis.
Author:	Thorsen, Kasper\|Schepeler, Troels\|Oster, Bodil\|Rasmussen, Mads H\|Vang, Soren\|Wang, Kai\|Hansen, Kristian Q\|Lamy, Philippe\|Pedersen, Jakob Skou\|Eller, Asger\|Mansilla, Francisco\|Laurila, Kirsti\|Wiuf, Carsten\|Laurberg, Soren\|Dyrskjot, Lars\|Orntoft, Torben F\|A
PMID:	21999571

71.
Journal:	J Med Chem. 2011 Dec 22;54(24):8328-42.
Title:	Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing.
Author:	Reader, John C\|Matthews, Thomas P\|Klair, Suki\|Cheung, Kwai-Ming J\|Scanlon, Jane\|Proisy, Nicolas\|Addison, Glynn\|Ellard, John\|Piton, Nelly\|Taylor, Suzanne\|Cherry, Michael\|Fisher, Martin\|Boxall, Kathy\|Burns, Samantha\|Walton, Michael I\|Westwood, Isaac M\|Hayes
PMID:	22111927

72.
Journal:	Exp Ther Med. 2011 May;2(3):393-397.
Title:	Trifluorothymidine exhibits potent antitumor activity via the induction of DNA double-strand breaks.
Author:	Suzuki, Norihiko\|Nakagawa, Fumio\|Nukatsuka, Mamoru\|Fukushima, Masakazu
PMID:	22977515

73.
Journal:	Cancer Res. 2012 Feb 15;72(4):979-89.
Title:	Potentiation of the novel topoisomerase I inhibitor indenoisoquinoline LMP-400 by the cell checkpoint and Chk1-Chk2 inhibitor AZD7762.
Author:	Aris, Sheena M\|Pommier, Yves
PMID:	22189968

74.
Journal:	Int J Oncol. 2012 Jul;41(1):76-82.
Title:	Bortezomib induces G2-M arrest in human colon cancer cells through ROS-inducible phosphorylation of ATM-CHK1.
Author:	Hong, Yong Sang\|Hong, Seung-Woo\|Kim, Seung-Mi\|Jin, Dong-Hoon\|Shin, Jae-Sik\|Yoon, Dok Hyun\|Kim, Kyu-Pyo\|Lee, Jae-Lyun\|Heo, Dae Seog\|Lee, Jung Shin\|Kim, Tae Won
PMID:	22552540

75.
Journal:	Oncol Rep. 2012 Sep;28(3):855-61.
Title:	Gene expression profiles of tumor regression grade in locally advanced rectal cancer after neoadjuvant chemoradiotherapy.
Author:	Saigusa, Susumu\|Tanaka, Koji\|Toiyama, Yuji\|Matsushita, Kohei\|Kawamura, Mikio\|Okugawa, Yoshinaga\|Hiro, Junichiro\|Inoue, Yasuhiro\|Uchida, Keiichi\|Mohri, Yasuhiko\|Kusunoki, Masato
PMID:	22711167

76.
Journal:	Int J Radiat Oncol Biol Phys. 2012 Dec 1;84(5):e613-20.
Title:	Short hairpin RNA suppression of thymidylate synthase produces DNA mismatches and results in excellent radiosensitization.
Author:	Flanagan, Sheryl A\|Cooper, Kristin S\|Mannava, Sudha\|Nikiforov, Mikhail A\|Shewach, Donna S
PMID:	22867891

77.
Journal:	Life Sci. 2012 Dec 17;91(25-26):1336-44.
Title:	Phenethyl caffeate benzo[kl]xanthene lignan with DNA interacting properties induces DNA damage and apoptosis in colon cancer cells.
Author:	Vijayakurup, Vinod\|Carmela, Spatafora\|Carmelo, Daquino\|Corrado, Tringali\|Srinivas, Priya\|Gopala, Srinivas
PMID:	23123449

78.
Journal:	Oncogene. 2013 Jan 31;32(5):577-88.
Title:	Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells.
Author:	Origanti, S\|Cai, S-r\|Munir, A Z\|White, L S\|Piwnica-Worms, H
PMID:	22430210

79.
Journal:	Int J Radiat Oncol Biol Phys. 2013 Mar 15;85(4):1119-26.
Title:	Sensitization of tumor to (2)(1)(2)Pb radioimmunotherapy by gemcitabine involves initial abrogation of G2 arrest and blocked DNA damage repair by interference with Rad51.
Author:	Yong, Kwon Joong\|Milenic, Diane E\|Baidoo, Kwamena E\|Brechbiel, Martin W
PMID:	23200172

80.
Journal:	J Med Chem. 2013 Mar 14;56(5):2125-38.
Title:	Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-y l}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity.
Author:	Foote, Kevin M\|Blades, Kevin\|Cronin, Anna\|Fillery, Shaun\|Guichard, Sylvie S\|Hassall, Lorraine\|Hickson, Ian\|Jacq, Xavier\|Jewsbury, Philip J\|McGuire, Thomas M\|Nissink, J Willem M\|Odedra, Rajesh\|Page, Ken\|Perkins, Paula\|Suleman, Abid\|Tam, Kin\|Thommes, Pia\|Br
PMID:	23394205

81.
Journal:	Int J Oncol. 2013 May;42(5):1644-53.
Title:	Acquired irinotecan resistance is accompanied by stable modifications of cell cycle dynamics independent of MSI status.
Author:	Petitprez, Amelie\|Poindessous, Virginie\|Ouaret, Djamila\|Regairaz, Marie\|Bastian, Gerard\|Guerin, Eric\|Escargueil, Alexandre E\|Larsen, Annette K
PMID:	23546019

82.
Journal:	Cancer Sci. 2013 Aug;104(8):1062-6.
Title:	HY-1 induces G(2)/M cell cycle arrest in human colon cancer cells through the ATR-Chk1-Cdc25C and Weel pathways.
Author:	Zhao, Yu\|Wu, Zhonghua\|Zhang, Yuting\|Zhu, Li
PMID:	23600770

83.
Journal:	Int J Oncol. 2013 Jul;43(1):210-8.
Title:	Influence of MLH1 on colon cancer sensitivity to poly(ADP-ribose) polymerase inhibitor combined with irinotecan.
Author:	Tentori, Lucio\|Leonetti, Carlo\|Muzi, Alessia\|Dorio, Annalisa Susanna\|Porru, Manuela\|Dolci, Susanna\|Campolo, Federica\|Vernole, Patrizia\|Lacal, Pedro Miguel\|Praz, Francoise\|Graziani, Grazia
PMID:	23653048

84.
Journal:	Cytotechnology. 2013 Dec;65(6):927-36.
Title:	Anticancer effect of Tamarix gallica extracts on human colon cancer cells involves Erk1/2 and p38 action on G2/M cell cycle arrest.
Author:	Boulaaba, Mondher\|Tsolmon, Soninkhishig\|Ksouri, Riadh\|Han, Junkyu\|Kawada, Kiyokazu\|Smaoui, Abderrazak\|Abdelly, Chedly\|Isoda, Hiroko
PMID:	23801270

85.
Journal:	PLoS One. 2013 Nov 19;8(11):e81034.
Title:	Telomere-binding protein TPP1 modulates telomere homeostasis and confers radioresistance to human colorectal cancer cells.
Author:	Yang, Lei\|Wang, Wenbo\|Hu, Liu\|Yang, Xiaoxi\|Zhong, Juan\|Li, Zheng\|Yang, Hui\|Lei, Han\|Yu, Haijun\|Liao, ZhengKai\|Zhou, Fuxiang\|Xie, Conghua\|Zhou, Yunfeng
PMID:	24260532

86.
Journal:	Evid Based Complement Alternat Med. 2013;2013:529375.
Title:	In Vitro Antiproliferative Effect of Arthrocnemum indicum Extracts on Caco-2 Cancer Cells through Cell Cycle Control and Related Phenol LC-TOF-MS Identification.
Author:	Boulaaba, Mondher\|Mkadmini, Khaoula\|Tsolmon, Soninkhishig\|Han, Junkyu\|Smaoui, Abderrazak\|Kawada, Kiyokazu\|Ksouri, Riadh\|Isoda, Hiroko\|Abdelly, Chedly
PMID:	24348703

87.
Journal:	PLoS One. 2013 Dec 12;8(12):e82982.
Title:	Comparative analysis of radiosensitizers for K-RAS mutant rectal cancers.
Author:	Kleiman, Laura B\|Krebs, Angela M\|Kim, Stephen Y\|Hong, Theodore S\|Haigis, Kevin M
PMID:	24349411

88.
Journal:	Oncogene. 2014 Jul 31;33(31):4089-96.
Title:	Wnt-driven intestinal tumourigenesis is suppressed by Chk1 deficiency but enhanced by conditional haploinsufficiency.
Author:	Greenow, K R\|Clarke, A R\|Williams, G T\|Jones, R
PMID:	24037525

89.
Journal:	Invest New Drugs. 2014 Apr;32(2):213-26.
Title:	Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor.
Author:	King, Constance\|Diaz, Henry\|Barnard, Darlene\|Barda, David\|Clawson, David\|Blosser, Wayne\|Cox, Karen\|Guo, Sherry\|Marshall, Mark
PMID:	24114124

90.
Journal:	Free Radic Biol Med. 2014 Apr;69:86-95.
Title:	A dual-fluorescent reporter facilitates identification of thiol compounds that suppress microsatellite instability induced by oxidative stress.
Author:	Li, I-Chen\|Chiu, Chien-Yuan\|Wu, Chang-Lin\|Chi, Jhih-Ying\|Jian, Siao-Ru\|Wang, Shainn-Wei\|Chang, Christina L
PMID:	24412704

91.
Journal:	J Cell Physiol. 2014 Nov;229(11):1639-46.
Title:	Thymosin beta-4 knockdown in IEC-6 normal intestinal epithelial cells induces DNA re-replication via downregulating Emi1.
Author:	Chao, Ta-Chung\|Chen, Ke-Jay\|Tang, Mei-Chuan\|Chan, Li-Chuan\|Chen, Po-Min\|Tzeng, Cheng-Hwai\|Su, Yeu
PMID:	24615569

92.
Journal:	Cancer Biol Ther. 2014 Sep;15(9):1268-79.
Title:	Chk1-induced CCNB1 overexpression promotes cell proliferation and tumor growth in human colorectal cancer.
Author:	Fang, Yifeng\|Yu, Hong\|Liang, Xiao\|Xu, Junfen\|Cai, Xiujun
PMID:	24971465

93.
Journal:	BMC Cancer. 2014 Jul 4;14:483.
Title:	gammaH2AX and Chk1 phosphorylation as predictive pharmacodynamic biomarkers of Chk1 inhibitor-chemotherapy combination treatments.
Author:	Rawlinson, Rebecca\|Massey, Andrew J
PMID:	24996846

94.
Journal:	Oncotarget. 2014 Oct 30;5(20):9889-900.
Title:	Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy.
Author:	Martino-Echarri, Estefania\|Henderson, Beric R\|Brocardo, Mariana G
PMID:	25301724

95.
Journal:	Int J Oncol. 2015 Jan;46(1):63-70.
Title:	5FU resistance abrogates the amplified cytotoxic effects induced by inhibiting checkpoint kinase 1 in p53mutated colon cancer cells.
Author:	Akasaka, Tomofumi\|Tsujii, Masahiko\|Kondo, Jumpei\|Hayashi, Yoshito\|Ying, Jin\|Lu, Yuquan\|Kato, Motohiko\|Yamada, Takuya\|Yamamoto, Shunsuke\|Inoue, Takuya\|Tsujii, Yoshiki\|Maekawa, Akira\|Fujinaga, Tetsuji\|Shiraishi, Eri\|Hiyama, Satoshi\|Inoue, Takahiro\|Shinzaki,
PMID:	25310623

96.
Journal:	Eur J Med Chem. 2015 Mar 6;92:459-70.
Title:	Identification of novel aminothiazole and aminothiadiazole conjugated cyanopyridines as selective CHK1 inhibitors.
Author:	Gomha, Sobhi M\|Abdulla, Mohamed M\|Abou-Seri, Sahar M
PMID:	25594740

97.
Journal:	ChemMedChem. 2015 Apr;10(4):607-9.
Title:	Synthesis and in vitro antiproliferative activity of amido and amino analogues of the marine alkaloid isogranulatimide.
Author:	Lavrard, Hubert\|Salvetti, Beatrice\|Mathieu, Veronique\|Rodriguez, Frederic\|Kiss, Robert\|Delfourne, Evelyne
PMID:	25735892

98.
Journal:	J Cell Biol. 2015 Apr 13;209(1):33-46.
Title:	Excision of translesion synthesis errors orchestrates responses to helix-distorting DNA lesions.
Author:	Tsaalbi-Shtylik, Anastasia\|Ferras, Cristina\|Pauw, Bea\|Hendriks, Giel\|Temviriyanukul, Piya\|Carlee, Leone\|Calleja, Fabienne\|van Hees, Sandrine\|Akagi, Jun-Ichi\|Iwai, Shigenori\|Hanaoka, Fumio\|Jansen, Jacob G\|de Wind, Niels
PMID:	25869665

99.
Journal:	Carcinogenesis. 2015 Oct;36(10):1235-44.
Title:	DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis.
Author:	Fahrer, Jorg\|Frisch, Janina\|Nagel, Georg\|Kraus, Alexander\|Dorsam, Bastian\|Thomas, Adam D\|Reissig, Sonja\|Waisman, Ari\|Kaina, Bernd
PMID:	26243310

100.
Journal:	Oncotarget. 2015 Nov 3;6(34):35797-812.
Title:	Identification of novel, in vivo active Chk1 inhibitors utilizing structure guided drug design.
Author:	Massey, Andrew J\|Stokes, Stephen\|Browne, Helen\|Foloppe, Nicolas\|Fiumana, Andrea\|Scrace, Simon\|Fallowfield, Mandy\|Bedford, Simon\|Webb, Paul\|Baker, Lisa\|Christie, Mark\|Drysdale, Martin J\|Wood, Mike
PMID:	26437226

101.
Journal:	J Nat Prod. 2015 Dec 24;78(12):2983-93.
Title:	Antitumor Activity of Americanin A Isolated from the Seeds of Phytolacca americana by Regulating the ATM/ATR Signaling Pathway and the Skp2-p27 Axis in Human Colon Cancer Cells.
Author:	Jung, Cholomi\|Hong, Ji-Young\|Bae, Song Yi\|Kang, Sam Sik\|Park, Hyen Joo\|Lee, Sang Kook
PMID:	26595875

102.
Journal:	Mol Oncol. 2016 Jan;10(1):101-12.
Title:	mTORC1 and DNA-PKcs as novel molecular determinants of sensitivity to Chk1 inhibition.
Author:	Massey, Andrew J\|Stephens, Peter\|Rawlinson, Rebecca\|McGurk, Lauren\|Plummer, Ruth\|Curtin, Nicola J
PMID:	26471831

103.
Journal:	Cancer Med. 2016 Feb;5(2):370-85.
Title:	Mus81 knockdown improves chemosensitivity of hepatocellular carcinoma cells by inducing S-phase arrest and promoting apoptosis through CHK1 pathway.
Author:	Wu, Fan\|Chen, Wei-Jia\|Yan, Lun\|Tan, Guo-Qian\|Li, Wei-Tao\|Zhu, Xuan-Jin\|Ge, Xiao-Chuan\|Liu, Jian-Wei\|Wang, Bai-Lin
PMID:	26714930

104.
Journal:	Oncotarget. 2016 Feb 9;7(6):7080-95.
Title:	A synthetic lethal screen identifies ATR-inhibition as a novel therapeutic approach for POLD1-deficient cancers.
Author:	Hocke, Sandra\|Guo, Yang\|Job, Albert\|Orth, Michael\|Ziesch, Andreas\|Lauber, Kirsten\|De Toni, Enrico N\|Gress, Thomas M\|Herbst, Andreas\|Goke, Burkhard\|Gallmeier, Eike
PMID:	26755646

105.
Journal:	Biomed Pharmacother. 2016 Apr;79:308-14.
Title:	The novel anthraquinone derivative IMP1338 induces death of human cancer cells by p53-independent S and G2/M cell cycle arrest.
Author:	Choi, Hyun Kyung\|Ryu, Hwani\|Son, A-Rang\|Seo, Bitna\|Hwang, Sang-Gu\|Song, Jie-Young\|Ahn, Jiyeon
PMID:	27044842

106.
Journal:	Int J Oncol. 2016 Aug;49(2):487-98.
Title:	Combination treatment with flavonoid morin and telomerase inhibitor MST312 reduces cancer stem cell traits by targeting STAT3 and telomerase.
Author:	Chung, Seyung S\|Oliva, Bryant\|Dwabe, Sami\|Vadgama, Jaydutt V
PMID:	27279256

107.
Journal:	Cancer Biol Ther. 2016 Nov;17(11):1139-1148.
Title:	Chk1 and DNA-PK mediate TPEN-induced DNA damage in a ROS dependent manner in human colon cancer cells.
Author:	Rahal, Omar Nasser\|Fatfat, Maamoun\|Hankache, Carla\|Osman, Bassam\|Khalife, Hala\|Machaca, Khaled\|Muhtasib, Hala-Gali
PMID:	27690730

108.
Journal:	Cancer Lett. 2017 Apr 1;390:48-57.
Title:	The depletion of ATM inhibits colon cancer proliferation and migration via B56gamma2-mediated Chk1/p53/CD44 cascades.
Author:	Liu, Rui\|Tang, Jiajia\|Ding, Chaodong\|Liang, Weicheng\|Zhang, Li\|Chen, Tianke\|Xiong, Yan\|Dai, Xiaowei\|Li, Wenfeng\|Xu, Yunsheng\|Hu, Jin\|Lu, Liting\|Liao, Wanqin\|Lu, Xincheng
PMID:	28093285

109.
Journal:	Immunol Invest. 2017 Apr;46(3):221-238.
Title:	Immunomodulating and Immunoresistance Properties of Cancer-Initiating Cells: Implications for the Clinical Success of Immunotherapy.
Author:	Maccalli, Cristina\|Parmiani, Giorgio\|Ferrone, Soldano
PMID:	28287848

110.
Journal:	Clin Res Hepatol Gastroenterol. 2017 Oct;41(5):592-601.
Title:	Mus81 knockdown sensitizes colon cancer cells to chemotherapeutic drugs by activating CHK1 pathway.
Author:	Wu, Fan\|Su, Shu-Chao\|Tan, Guo-Qian\|Yan, Lun\|Li, Ting-Yue\|Zhang, Hao-Lu\|Yu, Ji-Shang\|Wang, Bai-Lin
PMID:	28291626

111.
Journal:	Mol Cell Biochem. 2017 Dec;436(1-2):29-38.
Title:	A novel function of hepatocyte growth factor in the activation of checkpoint kinase 1 phosphorylation in colon cancer cells.
Author:	Song, Na\|Che, Xiaofang\|Xu, Lu\|Qu, Jinglei\|Zheng, Huachuan\|Hou, Kezuo\|Qu, Xiujuan\|Liu, Yunpeng
PMID:	28573382

112.
Journal:	Oncol Rep. 2017 Oct;38(4):1941-1948.
Title:	Potential role of ZEB1 as a DNA repair regulator in colorectal cancer cells revealed by cancer-associated promoter profiling.
Author:	Wang, Miao\|He, Su-Fei\|Liu, Lei-Lei\|Sun, Xiao-Xia\|Yang, Fan\|Ge, Qian\|Wong, Wei-Kang\|Meng, Jing-Yan
PMID:	28791382

113.
Journal:	Oncotarget. 2017 Aug 1;8(34):57246-57264.
Title:	NSC30049 inhibits Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations.
Author:	Narayan, Satya\|Jaiswal, Aruna S\|Sharma, Ritika\|Nawab, Akbar\|Duckworth, Lizette Vila\|Law, Brian K\|Zajac-Kaye, Maria\|George, Thomas J\|Sharma, Jay\|Sharma, Arun K\|Hromas, Robert A
PMID:	28915668

114.
Journal:	Sci Rep. 2017 Sep 19;7(1):11864.
Title:	Oligo-Fucoidan prevents IL-6 and CCL2 production and cooperates with p53 to suppress ATM signaling and tumor progression.
Author:	Chen, Li-Mei\|Liu, Po-Yen\|Chen, Yen-An\|Tseng, Hong-Yu\|Shen, Pei-Chun\|Hwang, Pai-An\|Hsu, Hsin-Ling
PMID:	28928376

115.
Journal:	Biomed Res Int. 2017;2017:5718968.
Title:	XRRA1 Targets ATM/CHK1/2-Mediated DNA Repair in Colorectal Cancer.
Author:	Wang, Wenjun\|Guo, Minzhang\|Xia, Xiaojun\|Zhang, Chao\|Zeng, Yuan\|Wu, Sipei
PMID:	29082250

116.
Journal:	Oncotarget. 2017 Dec 6;8(69):113331-113344.
Title:	MAEL contributes to gastric cancer progression by promoting ILKAP degradation.
Author:	Zhang, Xing\|Ning, Yichong\|Xiao, Yuzhong\|Duan, Huaxin\|Qu, Guifang\|Liu, Xin\|Du, Yan\|Jiang, Dejian\|Zhou, Jianlin
PMID:	29371914

117.
Journal:	Oncotarget. 2017 Dec 6;8(70):115041-115053.
Title:	INO80 haploinsufficiency inhibits colon cancer tumorigenesis via replication stress-induced apoptosis.
Author:	Lee, Shin-Ai\|Lee, Han-Sae\|Hur, Shin-Kyoung\|Kang, Sang Won\|Oh, Goo Taeg\|Lee, Daekee\|Kwon, Jongbum
PMID:	29383140

118.
Journal:	Gut. 2018 May;67(5):903-917.
Title:	CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells.
Author:	Manic, Gwenola\|Signore, Michele\|Sistigu, Antonella\|Russo, Giorgio\|Corradi, Francesca\|Siteni, Silvia\|Musella, Martina\|Vitale, Sara\|De Angelis, Maria Laura\|Pallocca, Matteo\|Amoreo, Carla Azzurra\|Sperati, Francesca\|Di Franco, Simone\|Barresi, Sabina\|Policicch
PMID:	28389531

119.
Journal:	Oncogene. 2018 Jan 25;37(4):427-438.
Title:	AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11.
Author:	Piscitello, D\|Varshney, D\|Lilla, S\|Vizioli, M G\|Reid, C\|Gorbunova, V\|Seluanov, A\|Gillespie, D A\|Adams, P D
PMID:	28967905

120.
Journal:	Cancer Lett. 2018 Jan 1;412:264-271.
Title:	MicroRNA-195 desensitizes HCT116 human colon cancer cells to 5-fluorouracil.
Author:	Kim, Chongtae\|Hong, Youlim\|Lee, Heejin\|Kang, Hoin\|Lee, Eun Kyung
PMID:	29080751

121.
Journal:	Cancer Lett. 2018 Feb 28;415:58-72.
Title:	NFYB-induced high expression of E2F1 contributes to oxaliplatin resistance in colorectal cancer via the enhancement of CHK1 signaling.
Author:	Fang, Zejun\|Gong, Chaoju\|Yu, Songshan\|Zhou, Weihua\|Hassan, Waseem\|Li, Hongzhang\|Wang, Xue\|Hu, Yanyan\|Gu, Kaipeng\|Chen, Xixi\|Hong, Bing\|Bao, Yuyan\|Chen, Xiang\|Zhang, Xiaomin\|Liu, Hong
PMID:	29203250

122.
Journal:	Oncotarget. 2018 Jan 4;9(5):6308-6319.
Title:	A lethal synergy induced by phellinus linteus and camptothecin11 in colon cancer cells.
Author:	Yu, Tianqi\|Ganapathy, Suthakar\|Shen, Ling\|Peng, Bo\|Kim, Sung-Hoon\|Makriyannis, Alexandros\|Chen, Changyan
PMID:	29464074

123.
Journal:	PLoS One. 2018 Jun 5;13(6):e0197154.
Title:	The expression of telomere-related proteins and DNA damage response and their association with telomere length in colorectal cancer in Saudi patients.
Author:	Aljarbou, Ftoon\|Almousa, Nourah\|Bazzi, Mohammad\|Aldaihan, Sooad\|Alanazi, Mohammed\|Alharbi, Othman\|Almadi, Majid\|Aljebreen, Abdulrahman M\|Azzam, Nahla Ali\|Arafa, Maha\|Aldbass, Abeer\|Shaik, Jilani\|Alasirri, Shaheerah\|Warsy, Arjumand\|Alamri, Abdullah\|Parine,
PMID:	29870526

124.
Journal:	Oncotarget. 2018 Jan 23;9(42):26616-26624.
Title:	Association of genetic variants in ATR-CHEK1 and ATM-CHEK2 pathway genes with risk of colorectal cancer in a Chinese population.
Author:	Wang, Shijia\|Zhang, Yue\|Chen, Min\|Wang, Yong\|Feng, Yifei\|Xu, Ziwei\|Zhang, Dongsheng\|Sun, Yueming\|Fu, Zan
PMID:	29928473

125.
Journal:	Exp Mol Med. 2018 Aug 14;50(8):101.
Title:	Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells.
Author:	He, Lingfeng\|Zhu, Hong\|Zhou, Shiying\|Wu, Ting\|Wu, Huan\|Yang, Huan\|Mao, Huiwen\|SekharKathera, Chandra\|Janardhan, Avilala\|Edick, Ashlin M\|Zhang, Anna\|Hu, Zhigang\|Pan, Feiyan\|Guo, Zhigang
PMID:	30111797

126.
Journal:	Biomed Res Int. 2018 Jul 12;2018:3424956.
Title:	OCT4 Potentiates Radio-Resistance and Migration Activity of Rectal Cancer Cells by Improving Epithelial-Mesenchymal Transition in a ZEB1 Dependent Manner.
Author:	Shao, Minghai\|Bi, Tienan\|Ding, Wenxiu\|Yu, Changhui\|Jiang, Caiping\|Yang, Haihua\|Sun, Xinchen\|Yang, Min
PMID:	30112378

127.
Journal:	Mol Cancer Res. 2018 Sep 10. pii: 1541-7786.MCR-18-0650.
Title:	Repurposing of mTOR Complex inhibitors Attenuates MCL-1 and sensitizes to PARP inhibition.
Author:	Mattoo, Abid R\|Joun, Alex\|Jessup, J Milburn
PMID:	30201826

128.
Journal:	Oncol Lett. 2018 Oct;16(4):4671-4678.
Title:	Chaetominine induces cell cycle arrest in human leukemia K562 and colon cancer SW1116 cells.
Author:	Yao, Jingyun\|Xiao, Jianbo\|Wei, Xing\|Lu, Yanhua
PMID:	30214601

129.
Journal:	Cell Rep. 2018 Oct 9;25(2):398-412.e6.
Title:	Colonic Lysine Homocysteinylation Induced by High-Fat Diet Suppresses DNA Damage Repair.
Author:	Wang, Dan\|Zhao, Rui\|Qu, Yuan-Yuan\|Mei, Xin-Yu\|Zhang, Xuan\|Zhou, Qian\|Li, Yang\|Yang, Shao-Bo\|Zuo, Zhi-Gui\|Chen, Yi-Ming\|Lin, Yan\|Xu, Wei\|Chen, Chao\|Zhao, Shi-Min\|Zhao, Jian-Yuan
PMID:	30304680