Primary Site >> Colorectal Cancer
Gene >> CHEK1
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Ref: CHK1 frameshift mutations in genetically unstable colorectal and endometrial cancers. PMID: 10469457 |
Ref: Cell cycle molecular targets in novel anticancer drug discovery. PMID: 10788588 Ref: Small molecule modulators of cyclin-dependent kinases for cancer therapy. PMID: 11426645 |
Ref: UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1. PMID: 12384533 |
Ref: The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase. PMID: 12687013 |
Ref: p53-regulated transcriptional program associated with genotoxic stress-induced apoptosis. PMID: 15016801 Ref: The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe. PMID: 15048074 Ref: Abrogation of Chk1-mediated S/G2 checkpoint by UCN-01 enhances ara-C-induced cytotoxicity in human colon cancer cells. PMID: 15169628 Ref: Enhanced 7-ethyl-10-hydroxycamptothecin (SN-38) lethality by methylselenocysteine is associated with Chk2 phosphorylation at threonine-68 and down-regulation of Cdc6 expression. PMID: 15213307 Ref: ATM-dependent CHK2 activation induced by anticancer agent, irofulven. PMID: 15269203 Ref: ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. PMID: 15282542 Ref: Chk1, but not Chk2, is involved in the cellular response to DNA damaging agents: differential activity in cells expressing or not p53. PMID: 15326376 Ref: CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses. PMID: 15367709 Ref: 5-fluoro-2'-deoxyuridine-induced cdc25A accumulation correlates with premature mitotic entry and clonogenic death in human colon cancer cells. PMID: 15374972 Ref: Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic catastroph PMID: 15374978 |
Ref: p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine. PMID: 16407843 Ref: Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells. PMID: 16456034 Ref: Checkpoint kinase 1-mediated phosphorylation of Cdc25C and bad proteins are involved in antitumor effects of loratadine-induced G2/M phase cell-cycle arrest and apoptosis. PMID: 16649252 Ref: Synthesis and biological activities of 7-aza rebeccamycin analogues bearing the sugar moiety on the nitrogen of the pyridine ring. PMID: 16889964 Ref: Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks. PMID: 16905549 Ref: Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of indolylpyrazolones and indolylpyridazinedione. PMID: 16996169 Ref: The DNA damage checkpoint is activated during residual tumour cell survival to methotrexate treatment as an initial step of acquired drug resistance. PMID: 17075316 |
Ref: Excess ribonucleotide reductase R2 subunits coordinate the S phase checkpoint to facilitate DNA damage repair and recovery from replication stress. PMID: 17188250 Ref: 5-ASA affects cell cycle progression in colorectal cells by reversibly activating a replication checkpoint. PMID: 17241873 Ref: Lidamycin induces marked G2 cell cycle arrest in human colon carcinoma HT-29 cells through activation of p38 MAPK pathway. PMID: 17273739 Ref: Tubulozole-induced G2/M cell cycle arrest in human colon cancer cells through formation of microtubule polymerization mediated by ERK1/2 and Chk1 kinase activation. PMID: 17329004 Ref: Chk1 frameshift mutation in sporadic and hereditary non-polyposis colorectal cancers with microsatellite instability. PMID: 17408908 Ref: The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses. PMID: 17515603 Ref: Synthesis and biological activities of isogranulatimide analogues. PMID: 17582773 Ref: Synthesis and biological activities of new checkpoint kinase 1 inhibitors structurally related to granulatimide. PMID: 17722905 Ref: A proteomics analysis of cell signaling alterations in colorectal cancer. PMID: 17848589 Ref: The mammalian DNA replication elongation checkpoint: implication of Chk1 and relationship with origin firing as determined by single DNA molecule and single cell analyses. PMID: 17986860 Ref: Inhibition of Chk1 kills tetraploid tumor cells through a p53-dependent pathway. PMID: 18159231 |
Ref: Synthesis, in vitro antiproliferative activities, and Chk1 inhibitory properties of pyrrolo[3,4-a]carbazole-1,3-diones, pyrrolo[3,4-c]carbazole-1,3-diones, and 2-aminopyridazino[3,4-a]pyrrolo[3,4-c]carbazole-1,3,4,7-tetraone. PMID: 17502122 Ref: Activated neutrophils induce an hMSH2-dependent G2/M checkpoint arrest and replication errors at a (CA)13-repeat in colon epithelial cells. PMID: 18272544 Ref: Synthesis, checkpoint kinase 1 inhibitory properties and in vitro antiproliferative activities of new pyrrolocarbazoles. PMID: 18321713 Ref: CUGBP2 downregulation by prostaglandin E2 protects colon cancer cells from radiation-induced mitotic catastrophe. PMID: 18325984 Ref: Translation regulatory factor RBM3 is a proto-oncogene that prevents mitotic catastrophe. PMID: 18427544 Ref: Role of c-Abl kinase in DNA mismatch repair-dependent G2 cell cycle checkpoint arrest responses. PMID: 18480061 Ref: Mesalazine negatively regulates CDC25A protein expression and promotes accumulation of colon cancer cells in S phase. PMID: 18495657 Ref: Geldanamycin promotes premature mitotic entry and micronucleation in irradiated p53/p21 deficient colon carcinoma cells. PMID: 18504430 Ref: Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins. PMID: 18566216 Ref: Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells. PMID: 18632613 Ref: Cyclin B1 is an efficacy-predicting biomarker for Chk1 inhibitors. PMID: 18671143 Ref: Alterations of Chk1 and Chk2 expression in colon cancer. PMID: 18679694 |
Ref: 90-kDa heat shock protein inhibition abrogates the topoisomerase I poison-induced G2/M checkpoint in p53-null tumor cells by depleting Chk1 and Wee1. PMID: 18820127 Ref: Ascochlorin activates p53 in a manner distinct from DNA damaging agents. PMID: 19253369 Ref: Rimonabant inhibits human colon cancer cell growth and reduces the formation of precancerous lesions in the mouse colon. PMID: 19479993 Ref: Knockdown of Chk1 sensitizes human colon carcinoma HCT116 cells in a p53-dependent manner to lidamycin through abrogation of a G2/M checkpoint and induction of apoptosis. PMID: 19502782 Ref: Reduced ATR or Chk1 expression leads to chromosome instability and chemosensitization of mismatch repair-deficient colorectal cancer cells. PMID: 19570909 Ref: Hypoxia-mediated regulation of Cdc25A phosphatase by p21 and miR-21. PMID: 19738433 Ref: Naphthalimides induce G(2) arrest through the ATM-activated Chk2-executed pathway in HCT116 cells. PMID: 19881958 |
Ref: Checkpoint kinase 1 modulates sensitivity to cisplatin after spindle checkpoint activation in SW620 cells. PMID: 19931410 Ref: A role for Chk2 in DNA damage induced mitotic delays in human colorectal cancer cells. PMID: 20023427 Ref: The preclinical pharmacology and therapeutic activity of the novel CHK1 inhibitor SAR-020106. PMID: 20053762 Ref: NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling. PMID: 20090422 Ref: Loratadine dysregulates cell cycle progression and enhances the effect of radiation in human tumor cell lines. PMID: 20128919 Ref: p53-dependent G(1) arrest in 1st or 2nd cell cycle may protect human cancer cells from cell death after treatment with ionizing radiation and Chk1 inhibitors. PMID: 20590661 Ref: Possibility of paclitaxel as an alternative radiosensitizer to 5-fluorouracil for colon cancer. PMID: 20811685 |
Ref: A novel Chk inhibitor, XL-844, increases human cancer cell radiosensitivity through promotion of mitotic catastrophe. PMID: 20024691 Ref: Cutting edge: Chk1 directs senescence and mitotic catastrophe in recovery from G(2) checkpoint arrest. PMID: 20716119 Ref: Spatholobus suberectus inhibits cancer cell growth by inducing apoptosis and arresting cell cycle at G2/M checkpoint. PMID: 21073941 Ref: Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. PMID: 21186793 Ref: Cantharidin induces G2/M phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of CDK1 activity and caspase-dependent signaling pathways. PMID: 21271215 Ref: Inhibition of ataxia telangiectasia- and Rad3-related function abrogates the in vitro and in vivo tumorigenicity of human colon cancer cells through depletion of the CD133(+) tumor-initiating cell fraction. PMID: 21308861 Ref: Aflatoxin genotoxicity is associated with a defective DNA damage response bypassing p53 activation. PMID: 21382167 Ref: Phosphorylation of SMC1 by ATR is required for desferrioxamine (DFO)-induced apoptosis. PMID: 21390062 Ref: Adenomatous polyposis coli protein regulates the cellular response to DNA replication stress. PMID: 21664290 Ref: DNA damage signaling in response to 5-fluorouracil in three colorectal cancer cell lines with different mismatch repair and TP53 status. PMID: 21674128 Ref: Tumor-specific usage of alternative transcription start sites in colorectal cancer identified by genome-wide exon array analysis. PMID: 21999571 Ref: Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing. PMID: 22111927 Ref: Trifluorothymidine exhibits potent antitumor activity via the induction of DNA double-strand breaks. PMID: 22977515 |
Ref: Potentiation of the novel topoisomerase I inhibitor indenoisoquinoline LMP-400 by the cell checkpoint and Chk1-Chk2 inhibitor AZD7762. PMID: 22189968 Ref: Bortezomib induces G2-M arrest in human colon cancer cells through ROS-inducible phosphorylation of ATM-CHK1. PMID: 22552540 Ref: Gene expression profiles of tumor regression grade in locally advanced rectal cancer after neoadjuvant chemoradiotherapy. PMID: 22711167 Ref: Short hairpin RNA suppression of thymidylate synthase produces DNA mismatches and results in excellent radiosensitization. PMID: 22867891 Ref: Phenethyl caffeate benzo[kl]xanthene lignan with DNA interacting properties induces DNA damage and apoptosis in colon cancer cells. PMID: 23123449 |
Ref: Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells. PMID: 22430210 Ref: Sensitization of tumor to (2)(1)(2)Pb radioimmunotherapy by gemcitabine involves initial abrogation of G2 arrest and blocked DNA damage repair by interference with Rad51. PMID: 23200172 Ref: Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-y l}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity. PMID: 23394205 Ref: Acquired irinotecan resistance is accompanied by stable modifications of cell cycle dynamics independent of MSI status. PMID: 23546019 Ref: HY-1 induces G(2)/M cell cycle arrest in human colon cancer cells through the ATR-Chk1-Cdc25C and Weel pathways. PMID: 23600770 Ref: Influence of MLH1 on colon cancer sensitivity to poly(ADP-ribose) polymerase inhibitor combined with irinotecan. PMID: 23653048 Ref: Anticancer effect of Tamarix gallica extracts on human colon cancer cells involves Erk1/2 and p38 action on G2/M cell cycle arrest. PMID: 23801270 Ref: Telomere-binding protein TPP1 modulates telomere homeostasis and confers radioresistance to human colorectal cancer cells. PMID: 24260532 Ref: In Vitro Antiproliferative Effect of Arthrocnemum indicum Extracts on Caco-2 Cancer Cells through Cell Cycle Control and Related Phenol LC-TOF-MS Identification. PMID: 24348703 Ref: Comparative analysis of radiosensitizers for K-RAS mutant rectal cancers. PMID: 24349411 |
Ref: Wnt-driven intestinal tumourigenesis is suppressed by Chk1 deficiency but enhanced by conditional haploinsufficiency. PMID: 24037525 Ref: Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor. PMID: 24114124 Ref: A dual-fluorescent reporter facilitates identification of thiol compounds that suppress microsatellite instability induced by oxidative stress. PMID: 24412704 Ref: Thymosin beta-4 knockdown in IEC-6 normal intestinal epithelial cells induces DNA re-replication via downregulating Emi1. PMID: 24615569 Ref: Chk1-induced CCNB1 overexpression promotes cell proliferation and tumor growth in human colorectal cancer. PMID: 24971465 Ref: gammaH2AX and Chk1 phosphorylation as predictive pharmacodynamic biomarkers of Chk1 inhibitor-chemotherapy combination treatments. PMID: 24996846 Ref: Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy. PMID: 25301724 |
Ref: 5FU resistance abrogates the amplified cytotoxic effects induced by inhibiting checkpoint kinase 1 in p53mutated colon cancer cells. PMID: 25310623 Ref: Identification of novel aminothiazole and aminothiadiazole conjugated cyanopyridines as selective CHK1 inhibitors. PMID: 25594740 Ref: Synthesis and in vitro antiproliferative activity of amido and amino analogues of the marine alkaloid isogranulatimide. PMID: 25735892 Ref: Excision of translesion synthesis errors orchestrates responses to helix-distorting DNA lesions. PMID: 25869665 Ref: DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis. PMID: 26243310 Ref: Identification of novel, in vivo active Chk1 inhibitors utilizing structure guided drug design. PMID: 26437226 Ref: Antitumor Activity of Americanin A Isolated from the Seeds of Phytolacca americana by Regulating the ATM/ATR Signaling Pathway and the Skp2-p27 Axis in Human Colon Cancer Cells. PMID: 26595875 |
Ref: mTORC1 and DNA-PKcs as novel molecular determinants of sensitivity to Chk1 inhibition. PMID: 26471831 Ref: Mus81 knockdown improves chemosensitivity of hepatocellular carcinoma cells by inducing S-phase arrest and promoting apoptosis through CHK1 pathway. PMID: 26714930 Ref: A synthetic lethal screen identifies ATR-inhibition as a novel therapeutic approach for POLD1-deficient cancers. PMID: 26755646 Ref: The novel anthraquinone derivative IMP1338 induces death of human cancer cells by p53-independent S and G2/M cell cycle arrest. PMID: 27044842 Ref: Combination treatment with flavonoid morin and telomerase inhibitor MST312 reduces cancer stem cell traits by targeting STAT3 and telomerase. PMID: 27279256 Ref: Chk1 and DNA-PK mediate TPEN-induced DNA damage in a ROS dependent manner in human colon cancer cells. PMID: 27690730 |
Ref: The depletion of ATM inhibits colon cancer proliferation and migration via B56gamma2-mediated Chk1/p53/CD44 cascades. PMID: 28093285 Ref: Immunomodulating and Immunoresistance Properties of Cancer-Initiating Cells: Implications for the Clinical Success of Immunotherapy. PMID: 28287848 Ref: Mus81 knockdown sensitizes colon cancer cells to chemotherapeutic drugs by activating CHK1 pathway. PMID: 28291626 Ref: A novel function of hepatocyte growth factor in the activation of checkpoint kinase 1 phosphorylation in colon cancer cells. PMID: 28573382 Ref: Potential role of ZEB1 as a DNA repair regulator in colorectal cancer cells revealed by cancer-associated promoter profiling. PMID: 28791382 Ref: NSC30049 inhibits Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations. PMID: 28915668 Ref: Oligo-Fucoidan prevents IL-6 and CCL2 production and cooperates with p53 to suppress ATM signaling and tumor progression. PMID: 28928376 Ref: XRRA1 Targets ATM/CHK1/2-Mediated DNA Repair in Colorectal Cancer. PMID: 29082250 Ref: MAEL contributes to gastric cancer progression by promoting ILKAP degradation. PMID: 29371914 Ref: INO80 haploinsufficiency inhibits colon cancer tumorigenesis via replication stress-induced apoptosis. PMID: 29383140 |
Ref: CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells. PMID: 28389531 Ref: AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11. PMID: 28967905 Ref: MicroRNA-195 desensitizes HCT116 human colon cancer cells to 5-fluorouracil. PMID: 29080751 Ref: NFYB-induced high expression of E2F1 contributes to oxaliplatin resistance in colorectal cancer via the enhancement of CHK1 signaling. PMID: 29203250 Ref: A lethal synergy induced by phellinus linteus and camptothecin11 in colon cancer cells. PMID: 29464074 Ref: The expression of telomere-related proteins and DNA damage response and their association with telomere length in colorectal cancer in Saudi patients. PMID: 29870526 Ref: Association of genetic variants in ATR-CHEK1 and ATM-CHEK2 pathway genes with risk of colorectal cancer in a Chinese population. PMID: 29928473 Ref: Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells. PMID: 30111797 Ref: OCT4 Potentiates Radio-Resistance and Migration Activity of Rectal Cancer Cells by Improving Epithelial-Mesenchymal Transition in a ZEB1 Dependent Manner. PMID: 30112378 Ref: Repurposing of mTOR Complex inhibitors Attenuates MCL-1 and sensitizes to PARP inhibition. PMID: 30201826 Ref: Chaetominine induces cell cycle arrest in human leukemia K562 and colon cancer SW1116 cells. PMID: 30214601 Ref: Colonic Lysine Homocysteinylation Induced by High-Fat Diet Suppresses DNA Damage Repair. PMID: 30304680 |