Primary Site >> Colorectal Cancer
Gene >> CDKN2A
| 1. | |||||||||||
| Journal: | Cancer Res. 1995 Oct 15;55(20):4525-30. | ||||||||||
| Title: | Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. | ||||||||||
| Author: | Herman, J G|Merlo, A|Mao, L|Lapidus, R G|Issa, J P|Davidson, N E|Sidransky, D|Baylin, S B | ||||||||||
| PMID: | 7553621 | ||||||||||
| 2. | |||||||||||
| Journal: | Cancer Res. 1995 Oct 15;55(20):4531-5. | ||||||||||
| Title: | Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. | ||||||||||
| Author: | Gonzalez-Zulueta, M|Bender, C M|Yang, A S|Nguyen, T|Beart, R W|Van Tornout, J M|Jones, P A | ||||||||||
| PMID: | 7553622 | ||||||||||
| 3. | |||||||||||
| Journal: | Toxicol Lett. 1995 Dec;82-83:1-7. | ||||||||||
| Title: | 1995 Deichmann Lecture--p53 tumor suppressor gene: at the crossroads of molecular carcinogenesis, molecular epidemiology and cancer risk assessment. | ||||||||||
| Author: | Harris, C C | ||||||||||
| PMID: | 8597035 | ||||||||||
| 4. | |||||||||||
| Journal: | Cancer Res. 1996 Feb 15;56(4):722-7. | ||||||||||
| Title: | Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B. | ||||||||||
| Author: | Herman, J G|Jen, J|Merlo, A|Baylin, S B | ||||||||||
| PMID: | 8631003 | ||||||||||
| 5. | |||||||||||
| Journal: | Mol Carcinog. 1996 May;16(1):53-60. | ||||||||||
| Title: | Suppression of growth in vitro and tumorigenicity in vivo of human carcinoma cell lines by transfected p16INK4. | ||||||||||
| Author: | Spillare, E A|Okamoto, A|Hagiwara, K|Demetrick, D J|Serrano, M|Beach, D|Harris, C C | ||||||||||
| PMID: | 8634094 | ||||||||||
| 6. | |||||||||||
| Journal: | Biochem Biophys Res Commun. 1996 Sep 24;226(3):791-5. | ||||||||||
| Title: | Activation but not inactivation of the MTS1 gene is associated with primary colorectal carcinomas. | ||||||||||
| Author: | Ohhara, M|Esumi, M|Kurosu, Y | ||||||||||
| PMID: | 8831691 | ||||||||||
| 7. | |||||||||||
| Journal: | Cancer Res. 1996 Oct 15;56(20):4662-5. | ||||||||||
| Title: | Microsatellite instability-associated mutations associate preferentially with the intestinal type of primary gastric carcinomas in a high-risk population. | ||||||||||
| Author: | Chung, Y J|Song, J M|Lee, J Y|Jung, Y T|Seo, E J|Choi, S W|Rhyu, M G | ||||||||||
| PMID: | 8840981 | ||||||||||
| 8. | |||||||||||
| Journal: | Recent Results Cancer Res. 1996;142:1-8. | ||||||||||
| Title: | The molecular biology of esophageal carcinoma. | ||||||||||
| Author: | Meltzer, S J | ||||||||||
| PMID: | 8893331 | ||||||||||
| 9. | |||||||||||
| Journal: | Nihon Rinsho. 1996 Apr;54(4):965-71. | ||||||||||
| Title: | [RB gene expression in gastrointestinal tract]. | ||||||||||
| Author: | Monden, T|Yamamoto, H|Ikeda, K|Izawa, H|Tsujie, M|Ohnishi, T|Miyoshi, Y|Sekimoto, M|Tomita, N|Monden, M | ||||||||||
| PMID: | 8920658 | ||||||||||
| 10. | |||||||||||
| Journal: | Nihon Rinsho. 1996 Apr;54(4):1054-9. | ||||||||||
| Title: | [Cyclin D, CDK4 and p16 expression in colorectal cancer]. | ||||||||||
| Author: | Ikeda, K|Monden, T|Tsujie, M|Izawa, H|Yamamoto, H|Ohnishi, T|Ohue, M|Sekimoto, M|Tomita, N|Monden, M | ||||||||||
| PMID: | 8920673 | ||||||||||
| 11. | |||||||||||
| Journal: | Cancer Res. 1996 Dec 15;56(24):5713-9. | ||||||||||
| Title: | Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice. | ||||||||||
| Author: | Reyes, G|Villanueva, A|Garcia, C|Sancho, F J|Piulats, J|Lluis, F|Capella, G | ||||||||||
| PMID: | 8971180 | ||||||||||
| 12. | |||||||||||
| Journal: | Am J Surg. 1997 Jan;173(1):37-41; discussion 42-3. | ||||||||||
| Title: | Advances in molecular genetics. | ||||||||||
| Author: | Lairmore, T C|Norton, J A | ||||||||||
| PMID: | 9046882 | ||||||||||
| 13. | |||||||||||
| Journal: | Cancer Res. 1997 Aug 15;57(16):3370-4. | ||||||||||
| Title: | Association between CpG island methylation and microsatellite instability in colorectal cancer. | ||||||||||
| Author: | Ahuja, N|Mohan, A L|Li, Q|Stolker, J M|Herman, J G|Hamilton, S R|Baylin, S B|Issa, J P | ||||||||||
| PMID: | 9269998 | ||||||||||
| 14. | |||||||||||
| Journal: | Jpn J Cancer Res. 1997 Sep;88(9):855-60. | ||||||||||
| Title: | Expressions of cell cycle regulators in human colorectal cancer cell lines. | ||||||||||
| Author: | Tominaga, O|Nita, M E|Nagawa, H|Fujii, S|Tsuruo, T|Muto, T | ||||||||||
| PMID: | 9369933 | ||||||||||
| 15. | |||||||||||
| Journal: | J Cell Biochem Suppl. 1997;28-29:64-73. | ||||||||||
| Title: | Genetic markers for early detection of lung cancer and outcome measures for response to chemoprevention. | ||||||||||
| Author: | Wiest, J S|Franklin, W A|Drabkin, H|Gemmill, R|Sidransky, D|Anderson, M W | ||||||||||
| PMID: | 9589350 | ||||||||||
| 16. | |||||||||||
| Journal: | Semin Surg Oncol. 1998 Jan-Feb;14(1):3-12. | ||||||||||
| Title: | Molecular changes during the genesis of human gliomas. | ||||||||||
| Author: | Sehgal, A | ||||||||||
| PMID: | 9407626 | ||||||||||
| 17. | |||||||||||
| Journal: | Cancer Res. 1998 Jan 1;58(1):109-13. | ||||||||||
| Title: | Novel mutations in the p16/CDKN2A binding region of the cyclin-dependent kinase-4 gene. | ||||||||||
| Author: | Tsao, H|Benoit, E|Sober, A J|Thiele, C|Haluska, F G | ||||||||||
| PMID: | 9426066 | ||||||||||
| 18. | |||||||||||
| Journal: | Mol Carcinog. 1998 Jan;21(1):37-49. | ||||||||||
| Title: | Decreased expression of the adenomatous polyposis coli (Apc) and mutated in colorectal cancer (Mcc) genes in mouse lung neoplasia. | ||||||||||
| Author: | Oreffo, V I|Robinson, S|You, M|Wu, M C|Malkinson, A M | ||||||||||
| PMID: | 9473770 | ||||||||||
| 19. | |||||||||||
| Journal: | Cancer Res. 1998 Feb 15;58(4):591-3. | ||||||||||
| Title: | Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia. | ||||||||||
| Author: | Myohanen, S K|Baylin, S B|Herman, J G | ||||||||||
| PMID: | 9485004 | ||||||||||
| 20. | |||||||||||
| Journal: | J Pathol. 1998 Feb;184(2):148-52. | ||||||||||
| Title: | A comparison of the genetic pathways involved in the pathogenesis of three types of colorectal cancer. | ||||||||||
| Author: | Tomlinson, I|Ilyas, M|Johnson, V|Davies, A|Clark, G|Talbot, I|Bodmer, W | ||||||||||
| PMID: | 9602705 | ||||||||||
| 21. | |||||||||||
| Journal: | Jpn J Clin Oncol. 1998 Mar;28(3):192-5. | ||||||||||
| Title: | Identification and characterization of families with aggregation of lung cancer. | ||||||||||
| Author: | Tomizawa, Y|Adachi, J|Kohno, T|Yamaguchi, N|Saito, R|Yokota, J | ||||||||||
| PMID: | 9614442 | ||||||||||
| 22. | |||||||||||
| Journal: | Cancer Res. 1998 Jun 1;58(11):2339-42. | ||||||||||
| Title: | Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. | ||||||||||
| Author: | Su, G H|Hilgers, W|Shekher, M C|Tang, D J|Yeo, C J|Hruban, R H|Kern, S E | ||||||||||
| PMID: | 9622070 | ||||||||||
| 23. | |||||||||||
| Journal: | Cancer Res. 1998 Sep 1;58(17):3942-5. | ||||||||||
| Title: | Hypermethylation of the p16INK4a promoter in colectomy specimens of patients with long-standing and extensive ulcerative colitis. | ||||||||||
| Author: | Hsieh, C J|Klump, B|Holzmann, K|Borchard, F|Gregor, M|Porschen, R | ||||||||||
| PMID: | 9731506 | ||||||||||
| 24. | |||||||||||
| Journal: | Genomics. 1998 Oct 15;53(2):129-36. | ||||||||||
| Title: | At least four loci and gender are associated with susceptibility to the chemical induction of lung adenomas in A/J x BALB/c mice. | ||||||||||
| Author: | Festing, M F|Lin, L|Devereux, T R|Gao, F|Yang, A|Anna, C H|White, C M|Malkinson, A M|You, M | ||||||||||
| PMID: | 9790761 | ||||||||||
| 25. | |||||||||||
| Journal: | Clin Chem Lab Med. 1998 Aug;36(8):645-8. | ||||||||||
| Title: | Screening for tumour suppressor p16(CDKN2A) germline mutations in Israeli melanoma families. | ||||||||||
| Author: | Yakobson, E A|Zlotogorski, A|Shafir, R|Cohen, M|Icekson, M|Landau, M|Brenner, S|Usher, S|Peretz, H | ||||||||||
| PMID: | 9806478 | ||||||||||
| 26. | |||||||||||
| Journal: | Mol Cell Biochem. 1998 Nov;188(1-2):21-30. | ||||||||||
| Title: | Sodium butyrate induces retinoblastoma protein dephosphorylation, p16 expression and growth arrest of colon cancer cells. | ||||||||||
| Author: | Schwartz, B|Avivi-Green, C|Polak-Charcon, S | ||||||||||
| PMID: | 9823007 | ||||||||||
| 27. | |||||||||||
| Journal: | Cancer Res. 1998 Dec 1;58(23):5489-94. | ||||||||||
| Title: | Aging and DNA methylation in colorectal mucosa and cancer. | ||||||||||
| Author: | Ahuja, N|Li, Q|Mohan, A L|Baylin, S B|Issa, J P | ||||||||||
| PMID: | 9850084 | ||||||||||
| 28. | |||||||||||
| Journal: | Arch Dermatol Res. 1999 Jan;291(1):1-5. | ||||||||||
| Title: | Assessment of microsatellite instability and loss of heterozygosity in sporadic keratoacanthomas. | ||||||||||
| Author: | Langenbach, N|Kroiss, M M|Ruschoff, J|Schlegel, J|Landthaler, M|Stolz, W | ||||||||||
| PMID: | 10025721 | ||||||||||
| 29. | |||||||||||
| Journal: | Mol Cell Biol. 1999 May;19(5):3916-28. | ||||||||||
| Title: | Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a). | ||||||||||
| Author: | Mitra, J|Dai, C Y|Somasundaram, K|El-Deiry, W S|Satyamoorthy, K|Herlyn, M|Enders, G H | ||||||||||
| PMID: | 10207115 | ||||||||||
| 30. | |||||||||||
| Journal: | Gastroenterology. 1999 May;116(5):1063-71. | ||||||||||
| Title: | Association of K-ras mutations with p16 methylation in human colon cancer. | ||||||||||
| Author: | Guan, R J|Fu, Y|Holt, P R|Pardee, A B | ||||||||||
| PMID: | 10220498 | ||||||||||
| 31. | |||||||||||
| Journal: | Cancer Res. 1999 May 15;59(10):2302-6. | ||||||||||
| Title: | CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression. | ||||||||||
| Author: | Eads, C A|Danenberg, K D|Kawakami, K|Saltz, L B|Danenberg, P V|Laird, P W | ||||||||||
| PMID: | 10344733 | ||||||||||
| 32. | |||||||||||
| Journal: | Cancer Res. 1999 May 15;59(10):2307-12. | ||||||||||
| Title: | Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification. | ||||||||||
| Author: | Toyota, M|Ho, C|Ahuja, N|Jair, K W|Li, Q|Ohe-Toyota, M|Baylin, S B|Issa, J P | ||||||||||
| PMID: | 10344734 | ||||||||||
| 33. | |||||||||||
| Journal: | Int J Cancer. 1999 Jun 11;81(6):902-10. | ||||||||||
| Title: | Establishment and characterization of 12 human colorectal-carcinoma cell lines. | ||||||||||
| Author: | Oh, J H|Ku, J L|Yoon, K A|Kwon, H J|Kim, W H|Park, H S|Yeo, K S|Song, S Y|Chung, J K|Park, J G | ||||||||||
| PMID: | 10362137 | ||||||||||
| 34. | |||||||||||
| Journal: | Cancer Epidemiol Biomarkers Prev. 1999 Jun;8(6):501-6. | ||||||||||
| Title: | Aberrant methylation of p16INK4a in anatomic and gender-specific subtypes of sporadic colorectal cancer. | ||||||||||
| Author: | Wiencke, J K|Zheng, S|Lafuente, A|Lafuente, M J|Grudzen, C|Wrensch, M R|Miike, R|Ballesta, A|Trias, M | ||||||||||
| PMID: | 10385139 | ||||||||||
| 35. | |||||||||||
| Journal: | Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8681-6. | ||||||||||
| Title: | CpG island methylator phenotype in colorectal cancer. | ||||||||||
| Author: | Toyota, M|Ahuja, N|Ohe-Toyota, M|Herman, J G|Baylin, S B|Issa, J P | ||||||||||
| PMID: | 10411935 | ||||||||||
| 36. | |||||||||||
| Journal: | Hautarzt. 1999 Jun;50(6):398-405. | ||||||||||
| Title: | [Pathogenesis of malignant melanoma. Molecular biology aspect]. | ||||||||||
| Author: | Waldmann, V|Bock, M|Jackel, A|Deichmann, M|Dockendorff, K|Naher, H | ||||||||||
| PMID: | 10427507 | ||||||||||
| 37. | |||||||||||
| Journal: | Oncology. 1999;57(2):149-56. | ||||||||||
| Title: | Hypermethylation of the p16 gene in sporadic T3N0M0 stage colorectal cancers: association with DNA replication error and shorter survival. | ||||||||||
| Author: | Liang, J T|Chang, K J|Chen, J C|Lee, C C|Cheng, Y M|Hsu, H C|Wu, M S|Wang, S M|Lin, J T|Cheng, A L | ||||||||||
| PMID: | 10461063 | ||||||||||
| 38. | |||||||||||
| Journal: | Anticancer Drugs. 1999 Jun;10(5):471-6. | ||||||||||
| Title: | DNA methylation of retinoic acid receptor beta in breast cancer and possible therapeutic role of 5-aza-2'-deoxycytidine. | ||||||||||
| Author: | Bovenzi, V|Le, N L|Cote, S|Sinnett, D|Momparler, L F|Momparler, R L | ||||||||||
| PMID: | 10477167 | ||||||||||
| 39. | |||||||||||
| Journal: | Int J Cancer. 1999 Oct 29;83(3):309-13. | ||||||||||
| Title: | Distinct methylation pattern and microsatellite instability in sporadic gastric cancer. | ||||||||||
| Author: | Suzuki, H|Itoh, F|Toyota, M|Kikuchi, T|Kakiuchi, H|Hinoda, Y|Imai, K | ||||||||||
| PMID: | 10495421 | ||||||||||
| 40. | |||||||||||
| Journal: | Clin Cancer Res. 1999 Sep;5(9):2450-4. | ||||||||||
| Title: | Molecular detection of neoplastic cells in lymph nodes of metastatic colorectal cancer patients predicts recurrence. | ||||||||||
| Author: | Sanchez-Cespedes, M|Esteller, M|Hibi, K|Cope, F O|Westra, W H|Piantadosi, S|Herman, J G|Jen, J|Sidransky, D | ||||||||||
| PMID: | 10499618 | ||||||||||
| 41. | |||||||||||
| Journal: | Cytogenet Cell Genet. 1999;86(2):142-7. | ||||||||||
| Title: | Genome-wide allelotyping indicates increased loss of heterozygosity on 9p and 14q in early age of onset colorectal cancer. | ||||||||||
| Author: | Weber, T K|Conroy, J|Keitz, B|Rodriguez-Bigas, M|Petrelli, N J|Stoler, D L|Anderson, G R|Shows, T B|Nowak, N J | ||||||||||
| PMID: | 10545706 | ||||||||||
| 42. | |||||||||||
| Journal: | Cancer Res. 1999 Nov 1;59(21):5438-42. | ||||||||||
| Title: | Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype. | ||||||||||
| Author: | Toyota, M|Ahuja, N|Suzuki, H|Itoh, F|Ohe-Toyota, M|Imai, K|Baylin, S B|Issa, J P | ||||||||||
| PMID: | 10554013 | ||||||||||
| 43. | |||||||||||
| Journal: | Cancer Epidemiol Biomarkers Prev. 1999 Dec;8(12):1101-5. | ||||||||||
| Title: | Abnormalities in the expression of cell cycle-related proteins in tumors of the small bowel. | ||||||||||
| Author: | Arber, N|Hibshoosh, H|Yasui, W|Neugut, A I|Hibshoosh, A|Yao, Y|Sgambato, A|Yamamoto, H|Shapira, I|Rosenman, D|Fabian, I|Weinstein, I B|Tahara, E|Holt, P R | ||||||||||
| PMID: | 10613343 | ||||||||||
| 44. | |||||||||||
| Journal: | Neoplasia. 1999 Dec;1(6):544-56. | ||||||||||
| Title: | p53-independent inhibition of proliferation and p21(WAF1/Cip1)-modulated induction of cell death by the antioxidants N-acetylcysteine and vitamin E. | ||||||||||
| Author: | Nargi, J L|Ratan, R R|Griffin, D E | ||||||||||
| PMID: | 10935502 | ||||||||||
| 45. | |||||||||||
| Journal: | World J Gastroenterol. 1999 Oct;5(5):451-454. | ||||||||||
| Title: | Methylation status of p16 gene in colorectal carcinoma and normal colonic mucosa. | ||||||||||
| Author: | Zhang, Jing|Lai, Mao-De|Chen, Jian | ||||||||||
| PMID: | 11819489 | ||||||||||
| 46. | |||||||||||
| Journal: | Zhonghua Wai Ke Za Zhi. 1999 Aug;37(8):494-6. | ||||||||||
| Title: | [The expression of MTS1 gene product in transitional mucosa adjacent to rectal carcinomas and its clinical significance]. | ||||||||||
| Author: | Su, Q|Liu, E|Chen, C|Feng, Y|Wang, W|Wang, Z | ||||||||||
| PMID: | 11829899 | ||||||||||
| 47. | |||||||||||
| Journal: | Zhonghua Bing Li Xue Za Zhi. 1999 Dec;28(6):418-21. | ||||||||||
| Title: | [Microsatellite alterations on chromosome 9p21-22 in sporadic colorectal cancer]. | ||||||||||
| Author: | Zhang, Y|Lai, M | ||||||||||
| PMID: | 11869554 | ||||||||||
| 48. | |||||||||||
| Journal: | Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):710-5. | ||||||||||
| Title: | Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype. | ||||||||||
| Author: | Toyota, M|Ohe-Toyota, M|Ahuja, N|Issa, J P | ||||||||||
| PMID: | 10639144 | ||||||||||
| 49. | |||||||||||
| Journal: | Cancer Res. 2000 Jan 1;60(1):129-33. | ||||||||||
| Title: | Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status. | ||||||||||
| Author: | Esteller, M|Tortola, S|Toyota, M|Capella, G|Peinado, M A|Baylin, S B|Herman, J G | ||||||||||
| PMID: | 10646864 | ||||||||||
| 50. | |||||||||||
| Journal: | Oncogene. 2000 Feb 17;19(7):943-52. | ||||||||||
| Title: | DNA methylator and mismatch repair phenotypes are not mutually exclusive in colorectal cancer cell lines. | ||||||||||
| Author: | Pao, M M|Liang, G|Tsai, Y C|Xiong, Z|Laird, P W|Jones, P A | ||||||||||
| PMID: | 10702803 | ||||||||||
| 51. | |||||||||||
| Journal: | J Natl Cancer Inst. 2000 Apr 19;92(8):636-41. | ||||||||||
| Title: | Adenovirus-mediated p14(ARF) gene transfer in human mesothelioma cells. | ||||||||||
| Author: | Yang, C T|You, L|Yeh, C C|Chang, J W|Zhang, F|McCormick, F|Jablons, D M | ||||||||||
| PMID: | 10772681 | ||||||||||
| 52. | |||||||||||
| Journal: | Nature. 2000 Apr 27;404(6781):1003-7. | ||||||||||
| Title: | CpG methylation is maintained in human cancer cells lacking DNMT1. | ||||||||||
| Author: | Rhee, I|Jair, K W|Yen, R W|Lengauer, C|Herman, J G|Kinzler, K W|Vogelstein, B|Baylin, S B|Schuebel, K E | ||||||||||
| PMID: | 10801130 | ||||||||||
| 53. | |||||||||||
| Journal: | Cancer Res. 2000 May 1;60(9):2368-71. | ||||||||||
| Title: | Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. | ||||||||||
| Author: | Esteller, M|Toyota, M|Sanchez-Cespedes, M|Capella, G|Peinado, M A|Watkins, D N|Issa, J P|Sidransky, D|Baylin, S B|Herman, J G | ||||||||||
| PMID: | 10811111 | ||||||||||
| 54. | |||||||||||
| Journal: | Mol Carcinog. 2000 Jul;28(3):139-47. | ||||||||||
| Title: | Differential expression of p16(INK4a) in azoxymethane-induced mouse colon tumorigenesis. | ||||||||||
| Author: | Wang, Q S|Papanikolaou, A|Nambiar, P R|Rosenberg, D W | ||||||||||
| PMID: | 10942530 | ||||||||||
| 55. | |||||||||||
| Journal: | Histol Histopathol. 2000 Jul;15(3):835-42. | ||||||||||
| Title: | Aging, methylation and cancer. | ||||||||||
| Author: | Ahuja, N|Issa, J P | ||||||||||
| PMID: | 10963127 | ||||||||||
| 56. | |||||||||||
| Journal: | Cancer J. 2000 Jul-Aug;6(4):234-42. | ||||||||||
| Title: | Cell cycle regulation of the G0/G1 transition in 5-fluorouracil-sensitive and -resistant human colon cancer cell lines. | ||||||||||
| Author: | McGinn, C J|Pestalozzi, B C|Drake, J C|Glennon, M C|Kunugi, K|Otterson, G|Allegra, C J|Johnston, P G|Kinsella, T J | ||||||||||
| PMID: | 11038143 | ||||||||||
| 57. | |||||||||||
| Journal: | Gastroenterology. 2000 Oct;119(4):929-42. | ||||||||||
| Title: | p16(INK4a) expression begins early in human colon neoplasia and correlates inversely with markers of cell proliferation. | ||||||||||
| Author: | Dai, C Y|Furth, E E|Mick, R|Koh, J|Takayama, T|Niitsu, Y|Enders, G H | ||||||||||
| PMID: | 11040180 | ||||||||||
| 58. | |||||||||||
| Journal: | Carcinogenesis. 2000 Nov;21(11):2057-64. | ||||||||||
| Title: | Correlations of partial and extensive methylation at the p14(ARF) locus with reduced mRNA expression in colorectal cancer cell lines and clinicopathological features in primary tumors. | ||||||||||
| Author: | Zheng, S|Chen, P|McMillan, A|Lafuente, A|Lafuente, M J|Ballesta, A|Trias, M|Wiencke, J K | ||||||||||
| PMID: | 11062168 | ||||||||||
| 59. | |||||||||||
| Journal: | Int J Cancer. 2000 Dec 1;88(5):804-9. | ||||||||||
| Title: | A novel MDM2 anti-sense oligonucleotide has anti-tumor activity and potentiates cytotoxic drugs acting by different mechanisms in human colon cancer. | ||||||||||
| Author: | Tortora, G|Caputo, R|Damiano, V|Bianco, R|Chen, J|Agrawal, S|Bianco, A R|Ciardiello, F | ||||||||||
| PMID: | 11072252 | ||||||||||
| 60. | |||||||||||
| Journal: | Am J Pathol. 2000 Dec;157(6):1947-53. | ||||||||||
| Title: | Human colorectal cancers with an intact p16/cyclin D1/pRb pathway have up-regulated p16 expression and decreased proliferation in small invasive tumor clusters. | ||||||||||
| Author: | Palmqvist, R|Rutegard, J N|Bozoky, B|Landberg, G|Stenling, R | ||||||||||
| PMID: | 11106567 | ||||||||||
| 61. | |||||||||||
| Journal: | Zhonghua Bing Li Xue Za Zhi. 2000 Apr;29(2):95-8. | ||||||||||
| Title: | [Methylation status of p16 gene in colorectal carcinoma and normal colonic mucosa]. | ||||||||||
| Author: | Zhang, J|Lai, M|Chen, J | ||||||||||
| PMID: | 11866898 | ||||||||||
| 62. | |||||||||||
| Journal: | Int J Cancer. 2001 Jan 15;91(2):205-12. | ||||||||||
| Title: | DNA methyltransferase expression and DNA methylation of CPG islands and peri-centromeric satellite regions in human colorectal and stomach cancers. | ||||||||||
| Author: | Kanai, Y|Ushijima, S|Kondo, Y|Nakanishi, Y|Hirohashi, S | ||||||||||
| PMID: | 11146446 | ||||||||||
| 63. | |||||||||||
| Journal: | Cancer Lett. 2001 Feb 10;163(1):17-23. | ||||||||||
| Title: | Mutations, methylation and expression of CDKN2a/p16 gene in colorectal cancer and normal colonic mucosa. | ||||||||||
| Author: | Trzeciak, L|Hennig, E|Kolodziejski, J|Nowacki, M|Ostrowski, J | ||||||||||
| PMID: | 11163104 | ||||||||||
| 64. | |||||||||||
| Journal: | J Clin Oncol. 2001 Jan 15;19(2):299-304. | ||||||||||
| Title: | K-ras and p16 aberrations confer poor prognosis in human colorectal cancer. | ||||||||||
| Author: | Esteller, M|Gonzalez, S|Risques, R A|Marcuello, E|Mangues, R|Germa, J R|Herman, J G|Capella, G|Peinado, M A | ||||||||||
| PMID: | 11208819 | ||||||||||
| 65. | |||||||||||
| Journal: | Lab Invest. 2001 Feb;81(2):217-29. | ||||||||||
| Title: | Methylation silencing and mutations of the p14ARF and p16INK4a genes in colon cancer. | ||||||||||
| Author: | Burri, N|Shaw, P|Bouzourene, H|Sordat, I|Sordat, B|Gillet, M|Schorderet, D|Bosman, F T|Chaubert, P | ||||||||||
| PMID: | 11232644 | ||||||||||
| 66. | |||||||||||
| Journal: | J Natl Cancer Inst. 2001 Mar 21;93(6):436-46. | ||||||||||
| Title: | Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4. | ||||||||||
| Author: | Soni, R|O'Reilly, T|Furet, P|Muller, L|Stephan, C|Zumstein-Mecker, S|Fretz, H|Fabbro, D|Chaudhuri, B | ||||||||||
| PMID: | 11259469 | ||||||||||
| 67. | |||||||||||
| Journal: | Cancer Res. 2001 Apr 1;61(7):2816-21. | ||||||||||
| Title: | p14ARF silencing by promoter hypermethylation mediates abnormal intracellular localization of MDM2. | ||||||||||
| Author: | Esteller, M|Cordon-Cardo, C|Corn, P G|Meltzer, S J|Pohar, K S|Watkins, D N|Capella, G|Peinado, M A|Matias-Guiu, X|Prat, J|Baylin, S B|Herman, J G | ||||||||||
| PMID: | 11306450 | ||||||||||
| 68. | |||||||||||
| Journal: | Cancer Lett. 2001 Jun 10;167(1):91-7. | ||||||||||
| Title: | Methylation of the hMLH1, p16, and MDR1 genes in colorectal carcinoma: associations with clinicopathological features. | ||||||||||
| Author: | Shannon, B A|Iacopetta, B J | ||||||||||
| PMID: | 11323103 | ||||||||||
| 69. | |||||||||||
| Journal: | Cancer Res. 2001 May 1;61(9):3573-7. | ||||||||||
| Title: | Accelerated age-related CpG island methylation in ulcerative colitis. | ||||||||||
| Author: | Issa, J P|Ahuja, N|Toyota, M|Bronner, M P|Brentnall, T A | ||||||||||
| PMID: | 11325821 | ||||||||||
| 70. | |||||||||||
| Journal: | Clin Chem Lab Med. 2001 Feb;39(2):121-8. | ||||||||||
| Title: | Heterogeneity of DNA methylation status analyzed by bisulfite-PCR-SSCP and correlation with clinico-pathological characteristics in colorectal cancer. | ||||||||||
| Author: | Maekawa, M|Sugano, K|Ushiama, M|Fukayama, N|Nomoto, K|Kashiwabara, H|Fujita, S|Kakizoe, T | ||||||||||
| PMID: | 11341745 | ||||||||||
| 71. | |||||||||||
| Journal: | Mol Cell Probes. 2001 Jun;15(3):183-5. | ||||||||||
| Title: | A novel highly informative polyA microsatellite on the telomeric side of the INK4a/ARF locus. | ||||||||||
| Author: | Chaubert, P|Burri, N|Cousin, P|Shaw, P | ||||||||||
| PMID: | 11352600 | ||||||||||
| 72. | |||||||||||
| Journal: | Langenbecks Arch Surg. 2001 Apr;386(3):163-71. | ||||||||||
| Title: | Carcinogenesis of cancer of the papilla and ampulla: pathophysiological facts and molecular biological mechanisms. | ||||||||||
| Author: | Esposito, I|Friess, H|Buchler, M W | ||||||||||
| PMID: | 11382316 | ||||||||||
| 73. | |||||||||||
| Journal: | Am J Pathol. 2001 Sep;159(3):1129-35. | ||||||||||
| Title: | CpG island methylation in colorectal adenomas. | ||||||||||
| Author: | Rashid, A|Shen, L|Morris, J S|Issa, J P|Hamilton, S R | ||||||||||
| PMID: | 11549606 | ||||||||||
| 74. | |||||||||||
| Journal: | J Natl Cancer Inst. 2001 Oct 3;93(19):1465-72. | ||||||||||
| Title: | Susceptibility of nonpromoter CpG islands to de novo methylation in normal and neoplastic cells. | ||||||||||
| Author: | Nguyen, C|Liang, G|Nguyen, T T|Tsao-Wei, D|Groshen, S|Lubbert, M|Zhou, J H|Benedict, W F|Jones, P A | ||||||||||
| PMID: | 11584062 | ||||||||||
| 75. | |||||||||||
| Journal: | Melanoma Res. 2001 Oct;11(5):447-9. | ||||||||||
| Title: | CDKN2A novel mutation in a patient from a melanoma-prone family. | ||||||||||
| Author: | Grammatico, P|Binni, F|Eibenschutz, L|De Bernardo, C|Grammatico, B|Rinaldi, R|De Simone, P|Catricala, C | ||||||||||
| PMID: | 11595880 | ||||||||||
| 76. | |||||||||||
| Journal: | Acta Oncol. 2001;40(5):633-7. | ||||||||||
| Title: | Microsatellite instability, PTEN and p53 germline mutations in glioma families. | ||||||||||
| Author: | Malmer, B|Gronberg, H|Andersson, U|Jonsson, B A|Henriksson, R | ||||||||||
| PMID: | 11669337 | ||||||||||
| 77. | |||||||||||
| Journal: | Chin Med J (Engl). 2001 Oct;114(10):1068-72. | ||||||||||
| Title: | Telomerase activity and homozygous deletions of the p16 gene in liver metastases of colorectal carcinoma. | ||||||||||
| Author: | Ma, J|Zhan, W|Peng, J|He, Y|Zheng, Z|Cai, S|Wang, L|Wang, J | ||||||||||
| PMID: | 11677769 | ||||||||||
| 78. | |||||||||||
| Journal: | Hum Mol Genet. 2001 Dec 15;10(26):3001-7. | ||||||||||
| Title: | DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis. | ||||||||||
| Author: | Esteller, M|Fraga, M F|Guo, M|Garcia-Foncillas, J|Hedenfalk, I|Godwin, A K|Trojan, J|Vaurs-Barriere, C|Bignon, Y J|Ramus, S|Benitez, J|Caldes, T|Akiyama, Y|Yuasa, Y|Launonen, V|Canal, M J|Rodriguez, R|Capella, G|Peinado, M A|Borg, A|Aaltonen, L A|Ponder, | ||||||||||
| PMID: | 11751682 | ||||||||||
| 79. | |||||||||||
| Journal: | World J Gastroenterol. 2001 Oct;7(5):722-5. | ||||||||||
| Title: | p16 gene methylation in colorectal cancers associated with Duke's staging. | ||||||||||
| Author: | Yi, J|Wang, Z W|Cang, H|Chen, Y Y|Zhao, R|Yu, B M|Tang, X M | ||||||||||
| PMID: | 11819863 | ||||||||||
| 80. | |||||||||||
| Journal: | Clin Cancer Res. 2002 Jan;8(1):17-21. | ||||||||||
| Title: | The potential prognostic, predictive, and therapeutic values of DNA methylation in cancer. Commentary re: J. Kwong et al., Promoter hypermethylation of multiple genes in nasopharyngeal carcinoma. Clin. Cancer Res., 8: 131-137, 2002, and H-Z. Zou et al., D | ||||||||||
| Author: | Widschwendter, Martin|Jones, Peter A | ||||||||||
| PMID: | 11801535 | ||||||||||
| 81. | |||||||||||
| Journal: | Clin Cancer Res. 2002 Jan;8(1):188-91. | ||||||||||
| Title: | Detection of aberrant p16 methylation in the serum of colorectal cancer patients. | ||||||||||
| Author: | Zou, Hong-Zhi|Yu, Bao-Ming|Wang, Zhi-Wei|Sun, Ji-Yuan|Cang, Hui|Gao, Fei|Li, Dong Hua|Zhao, Ren|Feng, Guo-Guang|Yi, Jing | ||||||||||
| PMID: | 11801557 | ||||||||||
| 82. | |||||||||||
| Journal: | Curr Opin Oncol. 2002 Mar;14(2):171-9. | ||||||||||
| Title: | Translational oncogenomics: toward rational therapeutic decision-making. | ||||||||||
| Author: | Rosell, Rafael|Monzo, Mariano|O'Brate, Aurora|Taron, Miquel | ||||||||||
| PMID: | 11880707 | ||||||||||
| 83. | |||||||||||
| Journal: | Am J Surg Pathol. 2002 Apr;26(4):472-8. | ||||||||||
| Title: | |||||||||||