Primary Site >> Colorectal Cancer
Gene >> CDKN2A
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Ref: Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. PMID: 7553621 Ref: Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. PMID: 7553622 Ref: 1995 Deichmann Lecture--p53 tumor suppressor gene: at the crossroads of molecular carcinogenesis, molecular epidemiology and cancer risk assessment. PMID: 8597035 |
Ref: Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B. PMID: 8631003 Ref: Suppression of growth in vitro and tumorigenicity in vivo of human carcinoma cell lines by transfected p16INK4. PMID: 8634094 Ref: Activation but not inactivation of the MTS1 gene is associated with primary colorectal carcinomas. PMID: 8831691 Ref: Microsatellite instability-associated mutations associate preferentially with the intestinal type of primary gastric carcinomas in a high-risk population. PMID: 8840981 Ref: The molecular biology of esophageal carcinoma. PMID: 8893331 Ref: [RB gene expression in gastrointestinal tract]. PMID: 8920658 Ref: [Cyclin D, CDK4 and p16 expression in colorectal cancer]. PMID: 8920673 Ref: Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice. PMID: 8971180 |
Ref: Advances in molecular genetics. PMID: 9046882 Ref: Association between CpG island methylation and microsatellite instability in colorectal cancer. PMID: 9269998 Ref: Expressions of cell cycle regulators in human colorectal cancer cell lines. PMID: 9369933 Ref: Genetic markers for early detection of lung cancer and outcome measures for response to chemoprevention. PMID: 9589350 |
Ref: Molecular changes during the genesis of human gliomas. PMID: 9407626 Ref: Novel mutations in the p16/CDKN2A binding region of the cyclin-dependent kinase-4 gene. PMID: 9426066 Ref: Decreased expression of the adenomatous polyposis coli (Apc) and mutated in colorectal cancer (Mcc) genes in mouse lung neoplasia. PMID: 9473770 Ref: Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia. PMID: 9485004 Ref: A comparison of the genetic pathways involved in the pathogenesis of three types of colorectal cancer. PMID: 9602705 Ref: Identification and characterization of families with aggregation of lung cancer. PMID: 9614442 Ref: Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. PMID: 9622070 Ref: Hypermethylation of the p16INK4a promoter in colectomy specimens of patients with long-standing and extensive ulcerative colitis. PMID: 9731506 Ref: At least four loci and gender are associated with susceptibility to the chemical induction of lung adenomas in A/J x BALB/c mice. PMID: 9790761 Ref: Screening for tumour suppressor p16(CDKN2A) germline mutations in Israeli melanoma families. PMID: 9806478 Ref: Sodium butyrate induces retinoblastoma protein dephosphorylation, p16 expression and growth arrest of colon cancer cells. PMID: 9823007 Ref: Aging and DNA methylation in colorectal mucosa and cancer. PMID: 9850084 |
Ref: Assessment of microsatellite instability and loss of heterozygosity in sporadic keratoacanthomas. PMID: 10025721 Ref: Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a). PMID: 10207115 Ref: Association of K-ras mutations with p16 methylation in human colon cancer. PMID: 10220498 Ref: CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression. PMID: 10344733 Ref: Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification. PMID: 10344734 Ref: Establishment and characterization of 12 human colorectal-carcinoma cell lines. PMID: 10362137 Ref: Aberrant methylation of p16INK4a in anatomic and gender-specific subtypes of sporadic colorectal cancer. PMID: 10385139 Ref: CpG island methylator phenotype in colorectal cancer. PMID: 10411935 Ref: [Pathogenesis of malignant melanoma. Molecular biology aspect]. PMID: 10427507 Ref: Hypermethylation of the p16 gene in sporadic T3N0M0 stage colorectal cancers: association with DNA replication error and shorter survival. PMID: 10461063 Ref: DNA methylation of retinoic acid receptor beta in breast cancer and possible therapeutic role of 5-aza-2'-deoxycytidine. PMID: 10477167 Ref: Distinct methylation pattern and microsatellite instability in sporadic gastric cancer. PMID: 10495421 Ref: Molecular detection of neoplastic cells in lymph nodes of metastatic colorectal cancer patients predicts recurrence. PMID: 10499618 Ref: Genome-wide allelotyping indicates increased loss of heterozygosity on 9p and 14q in early age of onset colorectal cancer. PMID: 10545706 Ref: Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype. PMID: 10554013 Ref: Abnormalities in the expression of cell cycle-related proteins in tumors of the small bowel. PMID: 10613343 Ref: p53-independent inhibition of proliferation and p21(WAF1/Cip1)-modulated induction of cell death by the antioxidants N-acetylcysteine and vitamin E. PMID: 10935502 Ref: Methylation status of p16 gene in colorectal carcinoma and normal colonic mucosa. PMID: 11819489 Ref: [The expression of MTS1 gene product in transitional mucosa adjacent to rectal carcinomas and its clinical significance]. PMID: 11829899 Ref: [Microsatellite alterations on chromosome 9p21-22 in sporadic colorectal cancer]. PMID: 11869554 |
Ref: Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype. PMID: 10639144 Ref: Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status. PMID: 10646864 Ref: DNA methylator and mismatch repair phenotypes are not mutually exclusive in colorectal cancer cell lines. PMID: 10702803 Ref: Adenovirus-mediated p14(ARF) gene transfer in human mesothelioma cells. PMID: 10772681 Ref: CpG methylation is maintained in human cancer cells lacking DNMT1. PMID: 10801130 Ref: Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. PMID: 10811111 Ref: Differential expression of p16(INK4a) in azoxymethane-induced mouse colon tumorigenesis. PMID: 10942530 Ref: Aging, methylation and cancer. PMID: 10963127 Ref: Cell cycle regulation of the G0/G1 transition in 5-fluorouracil-sensitive and -resistant human colon cancer cell lines. PMID: 11038143 Ref: p16(INK4a) expression begins early in human colon neoplasia and correlates inversely with markers of cell proliferation. PMID: 11040180 Ref: Correlations of partial and extensive methylation at the p14(ARF) locus with reduced mRNA expression in colorectal cancer cell lines and clinicopathological features in primary tumors. PMID: 11062168 Ref: A novel MDM2 anti-sense oligonucleotide has anti-tumor activity and potentiates cytotoxic drugs acting by different mechanisms in human colon cancer. PMID: 11072252 Ref: Human colorectal cancers with an intact p16/cyclin D1/pRb pathway have up-regulated p16 expression and decreased proliferation in small invasive tumor clusters. PMID: 11106567 Ref: [Methylation status of p16 gene in colorectal carcinoma and normal colonic mucosa]. PMID: 11866898 |
Ref: DNA methyltransferase expression and DNA methylation of CPG islands and peri-centromeric satellite regions in human colorectal and stomach cancers. PMID: 11146446 Ref: Mutations, methylation and expression of CDKN2a/p16 gene in colorectal cancer and normal colonic mucosa. PMID: 11163104 Ref: K-ras and p16 aberrations confer poor prognosis in human colorectal cancer. PMID: 11208819 Ref: Methylation silencing and mutations of the p14ARF and p16INK4a genes in colon cancer. PMID: 11232644 Ref: Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4. PMID: 11259469 Ref: p14ARF silencing by promoter hypermethylation mediates abnormal intracellular localization of MDM2. PMID: 11306450 Ref: Methylation of the hMLH1, p16, and MDR1 genes in colorectal carcinoma: associations with clinicopathological features. PMID: 11323103 Ref: Accelerated age-related CpG island methylation in ulcerative colitis. PMID: 11325821 Ref: Heterogeneity of DNA methylation status analyzed by bisulfite-PCR-SSCP and correlation with clinico-pathological characteristics in colorectal cancer. PMID: 11341745 Ref: A novel highly informative polyA microsatellite on the telomeric side of the INK4a/ARF locus. PMID: 11352600 Ref: Carcinogenesis of cancer of the papilla and ampulla: pathophysiological facts and molecular biological mechanisms. PMID: 11382316 Ref: CpG island methylation in colorectal adenomas. PMID: 11549606 Ref: Susceptibility of nonpromoter CpG islands to de novo methylation in normal and neoplastic cells. PMID: 11584062 Ref: CDKN2A novel mutation in a patient from a melanoma-prone family. PMID: 11595880 Ref: Microsatellite instability, PTEN and p53 germline mutations in glioma families. PMID: 11669337 Ref: Telomerase activity and homozygous deletions of the p16 gene in liver metastases of colorectal carcinoma. PMID: 11677769 Ref: DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis. PMID: 11751682 Ref: p16 gene methylation in colorectal cancers associated with Duke's staging. PMID: 11819863 |
Ref: The potential prognostic, predictive, and therapeutic values of DNA methylation in cancer. Commentary re: J. Kwong et al., Promoter hypermethylation of multiple genes in nasopharyngeal carcinoma. Clin. Cancer Res., 8: 131-137, 2002, and H-Z. Zou et al., D PMID: 11801535 Ref: Detection of aberrant p16 methylation in the serum of colorectal cancer patients. PMID: 11801557 Ref: Translational oncogenomics: toward rational therapeutic decision-making. PMID: 11880707 Ref: Evaluation of molecular markers in low-grade diffuse astrocytomas: loss of p16 and retinoblastoma protein expression is associated with short survival. PMID: 11914625 Ref: Analysis of key cell-cycle checkpoint proteins in colorectal tumours. PMID: 11920733 Ref: Methylation status and expression of human telomerase reverse transcriptase mRNA in relation to hypermethylation of the p16 gene in colorectal cancers as analyzed by bisulfite PCR-SSCP. PMID: 11932355 Ref: DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. PMID: 11932749 Ref: CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability. PMID: 11984524 Ref: CpG island methylation in aberrant crypt foci of the colorectum. PMID: 12000733 Ref: Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis. PMID: 12082630 Ref: Human p14(ARF)-mediated cell cycle arrest strictly depends on intact p53 signaling pathways. PMID: 12082636 Ref: Growth inhibition of human hepatoma cells by acyclic retinoid is associated with induction of p21(CIP1) and inhibition of expression of cyclin D1. PMID: 12124333 Ref: Detection of free-circulating tumor-associated DNA in plasma of colorectal cancer patients and its association with prognosis. PMID: 12124803 Ref: Adenovirus-mediated gene transfer of P16INK4/CDKN2 into bax-negative colon cancer cells induces apoptosis and tumor regression in vivo. PMID: 12136424 Ref: Inactivation of p21WAF1 sensitizes cells to apoptosis via an increase of both p14ARF and p53 levels and an alteration of the Bax/Bcl-2 ratio. PMID: 12151395 Ref: Altered expression of c-myc, p16 and p27 in rat colon tumors and its reversal by short-term treatment with chemopreventive agents. PMID: 12189186 Ref: Frequent RASSF1A tumour suppressor gene promoter methylation in Wilms' tumour and colorectal cancer. PMID: 12370819 Ref: Prognostic significance of calcium-binding protein S100A4 in colorectal cancer. PMID: 12404222 Ref: Molecular detection of p16 promoter methylation in the serum of colorectal cancer patients. PMID: 12406556 Ref: Detection of aberrant p16 methylation in the serum of colorectal cancer patients. PMID: 12411153 Ref: Morphological and molecular heterogeneity within nonmicrosatellite instability-high colorectal cancer. PMID: 12414620 Ref: Detection of tumor DNA in serum of colorectal cancer patients. PMID: 12460469 Ref: Colorectal cancers with both p16 and p14 methylation show invasive characteristics. PMID: 12716465 |
Ref: A potent cell-active allosteric inhibitor of murine DNA cytosine C5 methyltransferase. PMID: 12477724 Ref: Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer. PMID: 12482974 Ref: DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. PMID: 12496760 Ref: APC mutation and tumour budding in colorectal cancer. PMID: 12499439 Ref: CpG island methylation is a common finding in colorectal cancer cell lines. PMID: 12569385 Ref: Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations by a caspase-independent pathway. PMID: 12589031 Ref: Inhibition of colon tumor progression and angiogenesis by the Ink4a/Arf locus. PMID: 12591718 Ref: Frequent CpG island methylation in serrated adenomas of the colorectum. PMID: 12598316 Ref: SLIT2 axon guidance molecule is frequently inactivated in colorectal cancer and suppresses growth of colorectal carcinoma cells. PMID: 12615722 Ref: High incidence of microsatellite instability in colorectal cancer from African Americans. PMID: 12631615 Ref: Gender difference for promoter methylation pattern of hMLH1 and p16 in sporadic MSI colorectal cancer. PMID: 12671921 Ref: Molecular targeting and pharmacogenomics in the management of advanced bladder cancer. PMID: 12673700 Ref: Molecular detection of p16 promoter methylation in the serum of recurrent colorectal cancer patients. PMID: 12712439 Ref: Hypermethylation of the CDKN2A gene in colorectal cancer is associated with shorter survival. PMID: 12792748 Ref: Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancer. PMID: 12810640 Ref: Etiology of pancreatic cancer, with a hypothesis concerning the role of N-nitroso compounds and excess gastric acidity. PMID: 12837831 Ref: Differences in loss of p16INK4 protein expression by promoter methylation between left- and right-sided primary colorectal carcinomas. PMID: 12963980 Ref: Effects of DNA methylation on expression of tumor suppressor genes and proto-oncogene in human colon cancer cell lines. PMID: 12970888 Ref: Adverse prognostic effect of methylation in colorectal cancer is reversed by microsatellite instability. PMID: 14551292 Ref: Glucocorticoid receptor (GR) immunohistochemical expression is correlated with cell cycle-related molecules in human colon cancer. PMID: 14560994 Ref: Expressing patterns of p16 and CDK4 correlated to prognosis in colorectal carcinoma. PMID: 14562378 Ref: Inactivation of p16INK4a by CpG hypermethylation is not a frequent event in colorectal cancer. PMID: 14598358 Ref: Heterogeneous expression and association of beta-catenin, p16 and c-myc in multistage colorectal tumorigenesis and progression detected by tissue microarray. PMID: 14601048 Ref: Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. PMID: 14633667 Ref: Aberrant crypt foci as microscopic precursors of colorectal cancer. PMID: 14669304 Ref: Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer. PMID: 14695142 Ref: Reduced p16 expression correlates with lymphatic invasion in colorectal cancers. PMID: 14696398 Ref: [The study of 5-Aza-2'-deoxycytidine on transcription regulation of p16/CDKN2 gene demethylation in RKO human colorectal cell line]. PMID: 14703421 |
Ref: Promoter CpG methylation of tumor suppressor genes in colorectal cancer and its relationship to clinical features. PMID: 14719065 Ref: Differential impact of p16 inactivation by promoter methylation in non-small cell lung and colorectal cancer: clinical implications. PMID: 14719111 Ref: The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins. PMID: 14732230 Ref: Simultaneous mutations in K-ras and TP53 are indicative of poor prognosis in sporadic colorectal cancer. PMID: 14758132 Ref: Epstein-barr virus-positive gastric carcinoma has a distinct protein expression profile in comparison with epstein-barr virus-negative carcinoma. PMID: 15014022 Ref: Methylation patterns define two types of hyperplastic polyp associated with colorectal cancer. PMID: 15016754 Ref: [Regulation of histone acetylation on the expression of cell cycle-associated genes in human colon cancer cell lines]. PMID: 15059516 Ref: Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter. PMID: 15107822 Ref: Aberrant CpG island hypermethylation of multiple genes in colorectal neoplasia. PMID: 15122305 Ref: The association between methylenetetrahydrofolate reductase polymorphism and promoter methylation in proximal colon cancer. PMID: 15161007 Ref: Electron microscopy evidence that cytoplasmic localization of the p16(INK4A) "nuclear" cyclin-dependent kinase inhibitor (CKI) in tumor cells is specific and not an artifact. A study in non-small cell lung carcinomas. PMID: 15223748 Ref: Detection of lymph node micrometastases by gene promoter hypermethylation in samples obtained by endosonography- guided fine-needle aspiration biopsy. PMID: 15240535 Ref: Retinoblastoma protein function and p16INK4a expression in actinic keratosis, squamous cell carcinoma in situ and invasive squamous cell carcinoma of the skin and links between p16INK4a expression and infiltrative behavior. PMID: 15257310 Ref: Promoter hypermethylation frequency and BRAF mutations distinguish hereditary non-polyposis colon cancer from sporadic MSI-H colon cancer. PMID: 15340260 Ref: Use of DNA from human stools to detect aberrant CpG island methylation of genes implicated in colorectal cancer. PMID: 15342451 Ref: Dysfunction of p53 pathway in human colorectal cancer: analysis of p53 gene mutation and the expression of the p53-associated factors p14ARF, p33ING1, p21WAF1 and MDM2. PMID: 15375540 Ref: A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines. PMID: 15476557 Ref: The CpG island methylator phenotype is not associated with a personal or family history of cancer. PMID: 15492290 Ref: p16INK4a polymorphism: associations with tumour progression in patients with sporadic colorectal cancer. PMID: 15492837 Ref: Prognostic significance of pRb family and p16(INK4) alterations in colorectal cancer: an interesting point of view in a complex net of molecular signals. PMID: 15492982 Ref: Aberrant expression of pRb and p16(INK4), alone or in combination, indicates poor outcome after resection in patients with colorectal carcinoma. PMID: 15492985 Ref: Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. PMID: 15526363 Ref: Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation. PMID: 15542810 Ref: Genetic characterization of colorectal cancers in young patients based on chromosomal loss and microsatellite instability. PMID: 15545173 Ref: Immunohistochemical evaluation of thymidylate synthase (TS) and p16INK4a in advanced colorectal cancer: implication of TS expression in 5-FU-based adjuvant chemotherapy. PMID: 15591457 |
Ref: Progressive methylation during the serrated neoplasia pathway of the colorectum. PMID: 15389252 Ref: Genotype phenotype correlations in Israeli colorectal cancer patients. PMID: 15523694 Ref: 5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms. PMID: 15547111 Ref: Development and application of a multiplex PCR procedure for the detection of DNA methylation in colorectal cancer. PMID: 15643519 Ref: Aberrantly methylated CDKN2A, MGMT, and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps. PMID: 15709190 Ref: CHFR promoter hypermethylation in colon cancer correlates with the microsatellite instability phenotype. PMID: 15760919 Ref: Phenotype of microsatellite-stable colorectal carcinomas with CpG island methylation. PMID: 15767794 Ref: BRAF mutations in aberrant crypt foci and hyperplastic polyposis. PMID: 15793287 Ref: Low microsatellite instability is associated with poor prognosis in stage C colon cancer. PMID: 15800322 Ref: Methylation and expression of p16INK4 tumor suppressor gene in primary colorectal cancer tissues. PMID: 15809712 Ref: Clinicopathological features and microsatellite instability (MSI) in colorectal cancers from African Americans. PMID: 15856472 Ref: Array-based analysis of genomic DNA methylation patterns of the tumour suppressor gene p16INK4A promoter in colon carcinoma cell lines. PMID: 15860770 Ref: Gene-specific methylation and subsequent risk of colorectal adenomas among participants of the polyp prevention trial. PMID: 15894675 Ref: Activation of p53-dependent apoptosis by acute ablation of glycogen synthase kinase-3beta in colorectal cancer cells. PMID: 15958644 Ref: Evaluating the combination of molecular prognostic factors in tumor radiosensitivity in rectal cancer. PMID: 15966178 Ref: Colorectal cancer "methylator phenotype": fact or artifact? PMID: 15967110 Ref: Cyclin-dependent kinase inhibitors uncouple cell cycle progression from mitochondrial apoptotic functions in DNA-damaged cancer cells. PMID: 16002406 Ref: Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer. PMID: 16143123 Ref: Hypermethylation of the TPEF/HPP1 gene in primary and metastatic colorectal cancers. PMID: 16207479 Ref: Differing DNA methylation patterns and gene mutation frequencies in colorectal carcinomas from Middle Eastern countries. PMID: 16322286 Ref: p16(Ink4a) inhibits histologic progression and angiogenic signaling in min colon tumors. PMID: 16322687 Ref: p16 Gene methylation in colorectal tumors: correlation with clinicopathological features and prognostic value. PMID: 16352895 |
Ref: Distinct molecular features of colorectal carcinoma with signet ring cell component and colorectal carcinoma with mucinous component. PMID: 16118624 Ref: DNA methylation patterns in adenomas from FAP, multiple adenoma and sporadic colorectal carcinoma patients. PMID: 16152625 Ref: Senescence and telomere shortening induced by novel potent G-quadruplex interactive agents, quindoline derivatives, in human cancer cell lines. PMID: 16170347 Ref: Multiplexed profiling of candidate genes for CpG island methylation status using a flexible PCR/LDR/Universal Array assay. PMID: 16369045 Ref: Epigenetic inactivation of tumor suppressor genes in serum of patients with cutaneous melanoma. PMID: 16374457 Ref: CDKN2A common variant and multi-organ cancer risk--a population-based study. PMID: 16395703 Ref: CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies. PMID: 16407376 Ref: DNA hypermethylation in the normal colonic mucosa of patients with colorectal cancer. PMID: 16421593 Ref: Lymph node metastasis is infrequent in patients with highly-methylated colorectal cancer. PMID: 16475679 Ref: Aberrant crypt foci. PMID: 16475686 Ref: Profiling markers of prognosis in colorectal cancer. PMID: 16489072 Ref: Microsatellite instability in colorectal cancer. PMID: 16555243 Ref: Immunohistochemical expression of p16, p53, and p63 in colorectal adenomas and adenocarcinomas. PMID: 16575619 Ref: Analysis of molecular alterations in left- and right-sided colorectal carcinomas reveals distinct pathways of carcinogenesis: proposal for new molecular profile of colorectal carcinomas. PMID: 16645205 Ref: Precision and performance characteristics of bisulfite conversion and real-time PCR (MethyLight) for quantitative DNA methylation analysis. PMID: 16645207 Ref: p16(INK4a) promoter methylation and 9p21 allelic loss in colorectal carcinomas: relation with immunohistochemical p16(INK4a) expression and with tumor budding. PMID: 16647956 Ref: Prognostic value of p16INK4a and p14ARF gene hypermethylation in human colon cancer. PMID: 16675157 Ref: Methylation of p16 and Ras association domain family protein 1a during colorectal malignant transformation. PMID: 16687485 Ref: Epigenetic profiling of synchronous colorectal neoplasias by quantitative DNA methylation analysis. PMID: 16699497 Ref: CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer. PMID: 16708352 Ref: Microdissection-based allelotyping: a novel technique to determine the temporal sequence and biological aggressiveness of colorectal cancer. PMID: 16719202 Ref: Significance of P16INK4A hypermethylation gene in primary head/neck and colorectal tumors: it is a specific tissue event? Results of a 3-year GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study. PMID: 16760277 Ref: Molecular detection of TP53, Ki-Ras and p16INK4A promoter methylation in plasma of patients with colorectal cancer and its association with prognosis. Results of a 3-year GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study. PMID: 16760301 Ref: Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. PMID: 16797627 Ref: Relationship of the methylenetetrahydrofolate reductase C677T polymorphism with microsatellite instability and promoter hypermethylation in sporadic colorectal cancer. PMID: 16819711 Ref: Combined analysis of COX-2 and p53 expressions reveals synergistic inverse correlations with microsatellite instability and CpG island methylator phenotype in colorectal cancer. PMID: 16820091 Ref: Promoter methylation status of the MGMT, hMLH1, and CDKN2A/p16 genes in non-neoplastic mucosa of patients with and without colorectal adenomas. PMID: 16820927 Ref: Bak functionally complements for loss of Bax during p14ARF-induced mitochondrial apoptosis in human cancer cells. PMID: 16847458 Ref: Down-regulation of p21 (CDKN1A/CIP1) is inversely associated with microsatellite instability and CpG island methylator phenotype (CIMP) in colorectal cancer. PMID: 16850502 Ref: Influence of methylated p15 and p16 genes on clinicopathological features in colorectal cancer. PMID: 16872319 Ref: Relationship between point gene mutation, chromosomal abnormality, and tumour suppressor gene methylation status in colorectal adenomas. PMID: 16902913 Ref: Phenotype-genotype correlation: challenge of intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses. PMID: 16906516 Ref: Colorectal mucinous adenocarcinoma: the clinicopathologic features and significance of p16 and p53 expression. PMID: 16912910 Ref: Correlation of pathologic features with CpG island methylator phenotype (CIMP) by quantitative DNA methylation analysis in colorectal carcinoma. PMID: 16931963 Ref: Genetic and epigenetic changes in primary metastatic and nonmetastatic colorectal cancer. PMID: 16969349 Ref: APC gene methylation is inversely correlated with features of the CpG island methylator phenotype in colorectal cancer. PMID: 16981189 Ref: Correlation of microsatellite status, proliferation, apoptotic and selected immunohistochemical markers in colorectal carcinoma studied with tissue microarray. PMID: 17019973 Ref: CpG island methylator phenotype-low (CIMP-low) in colorectal cancer: possible associations with male sex and KRAS mutations. PMID: 17065427 Ref: Aberrant cytological localization of p16 and CDK4 in colorectal epithelia in the normal adenoma carcinoma sequence. PMID: 17072968 Ref: Quantitative analysis of plasma DNA in colorectal cancer patients: a novel prognostic tool. PMID: 17108210 Ref: Comparative analysis of mesenteric and peripheral blood circulating tumor DNA in colorectal cancer patients. PMID: 17108212 Ref: [Pancreatic cancer]. PMID: 17111879 Ref: Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points. PMID: 17122504 Ref: Association of smoking, CpG island methylator phenotype, and V600E BRAF mutations in colon cancer. PMID: 17148775 Ref: Promoter methylation precedes chromosomal alterations in colorectal cancer development. PMID: 17167178 Ref: [The effect of PKC-delta inhibitor Rottlerin on human colon cancer cell line SW1116 and its mechanism]. PMID: 17236547 Ref: The synergistic effect of 5-aza-2'-deoxycytidine and 5-fluorouracil on drug-resistant tumors. PMID: 17690560 |
Ref: Enhanced expression of hepatocyte growth factor activator inhibitor type 2-related small peptide at the invasive front of colon cancers. PMID: 16809422 Ref: Loss of nuclear p27 (CDKN1B/KIP1) in colorectal cancer is correlated with microsatellite instability and CIMP. PMID: 17086168 Ref: The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer. PMID: 17087942 Ref: Diet and lifestyle factor associations with CpG island methylator phenotype and BRAF mutations in colon cancer. PMID: 17096326 Ref: Effect of combined therapy with low-dose 5-aza-2'-deoxycytidine and irinotecan on colon cancer cell line HCT-15. PMID: 17195906 Ref: Cytoplasmic localization of p27 (cyclin-dependent kinase inhibitor 1B/KIP1) in colorectal cancer: inverse correlations with nuclear p27 loss, microsatellite instability, and CpG island methylator phenotype. PMID: 17239930 Ref: Promoter methylation of the mutated in colorectal cancer gene is a frequent early event in colorectal cancer. PMID: 17260021 Ref: TGFBR2 mutation is correlated with CpG island methylator phenotype in microsatellite instability-high colorectal cancer. PMID: 17270239 Ref: Evidence for the role of aberrant DNA methylation in the pathogenesis of Lynch syndrome adenomas. PMID: 17278092 Ref: Inhibition of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway decreases DNA methylation in colon cancer cells. PMID: 17307743 Ref: Molecular correlates with MGMT promoter methylation and silencing support CpG island methylator phenotype-low (CIMP-low) in colorectal cancer. PMID: 17339237 Ref: Fatty acid synthase overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype. PMID: 17350669 Ref: CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma. PMID: 17372756 Ref: Expression of peroxisome proliferator-activated receptor-gamma in colon cancer: correlation with histopathological parameters, cell cycle-related molecules, and patients' survival. PMID: 17393321 Ref: Rare CpG island methylator phenotype in ulcerative colitis-associated neoplasias. PMID: 17408633 Ref: Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet. PMID: 17449906 Ref: Comethylation of p16 and MGMT genes in colorectal carcinoma: correlation with clinicopathological features and prognostic value. PMID: 17451198 Ref: [Stem cell theory of colorectal cancer and its connection with molecular-biological data]. PMID: 17452307 Ref: Stool-based DNA testing, a new noninvasive method for colorectal cancer screening, the first report from Iran. PMID: 17461444 Ref: Lower specific micronutrient intake in colorectal cancer patients with tumors presenting promoter hypermethylation in p16(INK4a), p4(ARF) and hMLH1. PMID: 17465256 Ref: 18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high. PMID: 17474983 Ref: p21(Waf1/Cip1/Sdi1) mediates retinoblastoma protein degradation. PMID: 17486059 Ref: CDK4 inhibitors and apoptosis: a novel mechanism requiring nucleolar targeting of RelA. PMID: 17525529 Ref: Relationship between expression and methylation status of p16INK4a and the proliferative activity of different areas' tumour cells in human colorectal cancer. PMID: 17537196 Ref: Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample. PMID: 17591929 Ref: A highly sensitive method for the detection of p16 methylation in the serum of colorectal cancer patients. PMID: 17595762 Ref: Reduced likelihood of metastases in patients with microsatellite-unstable colorectal cancer. PMID: 17606714 Ref: MGMT germline polymorphism is associated with somatic MGMT promoter methylation and gene silencing in colorectal cancer. PMID: 17621591 Ref: Methylation levels of LINE-1 repeats and CpG island loci are inversely related in normal colonic mucosa. PMID: 17640302 Ref: Cell-cycle and apoptosis regulators (p16INK4A, p21CIP1, beta-catenin, survivin, and hTERT) and morphometry-defined MPECs predict metachronous cancer development in colorectal adenoma patients. PMID: 17641414 Ref: [Effects of extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway activation on proliferation and cell cycle associated genes in human colon cancer cells]. PMID: 17650425 Ref: Nuclear expression of E2F4 induces cell death via multiple pathways in normal human intestinal epithelial crypt cells but not in colon cancer cells. PMID: 17656449 Ref: Association of the SUV39H1 histone methyltransferase with the DNA methyltransferase 1 at mRNA expression level in primary colorectal cancer. PMID: 17657744 Ref: Effects of folate cycle disruption by the green tea polyphenol epigallocatechin-3-gallate. PMID: 17683969 Ref: Correlation of beta-catenin localization with cyclooxygenase-2 expression and CpG island methylator phenotype (CIMP) in colorectal cancer. PMID: 17710160 Ref: Identification of JTP-70902, a p15(INK4b)-inductive compound, as a novel MEK1/2 inhibitor. 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