Primary Site >> Biliary tract Cancer

Gene >> CDKN2A

1.
Journal: Cancer Res. 1995 Jul 1;55(13):2756-60.
Title: Mutations of p16Ink4/CDKN2 and p15Ink4B/MTS2 genes in biliary tract cancers.
Author: Yoshida, S|Todoroki, T|Ichikawa, Y|Hanai, S|Suzuki, H|Hori, M|Fukao, K|Miwa, M|Uchida, K
PMID: 7796400
2.
Journal: Hepatology. 1997 Mar;25(3):593-7.
Title: Frequency of mutation and deletion of the tumor suppressor gene CDKN2A (MTS1/p16) in hepatocellular carcinoma from an Australian population.
Author: Biden, K|Young, J|Buttenshaw, R|Searle, J|Cooksley, G|Xu, D B|Leggett, B
PMID: 9049204
3.
Journal: Hum Pathol. 1999 Jan;30(1):21-5.
Title: Gallbladder adenomas have molecular abnormalities different from those present in gallbladder carcinomas.
Author: Wistuba, I I|Miquel, J F|Gazdar, A F|Albores-Saavedra, J
PMID: 9923922
4.
Journal: J Surg Res. 1999 Jun 1;84(1):88-93.
Title: Chromosome 9p21 loss and p16 inactivation in primary sclerosing cholangitis-associated cholangiocarcinoma.
Author: Ahrendt, S A|Eisenberger, C F|Yip, L|Rashid, A|Chow, J T|Pitt, H A|Sidransky, D
PMID: 10334895
5.
Journal: Ann Oncol. 1999;10 Suppl 4:153-6.
Title: Biliopancreatic malignancy: screening the at risk patient with molecular markers.
Author: Caldas, C
PMID: 10436811
6.
Journal: J Hepatobiliary Pancreat Surg. 1999;6(3):237-44.
Title: Genetic abnormalities involved in the pathogenesis of gallbladder carcinoma.
Author: Wistuba, I I|Albores-Saavedra, J
PMID: 10526058
7.
Journal: Diagn Mol Pathol. 2000 Mar;9(1):41-6.
Title: TP53 mutations and mdm2 protein overexpression in cholangiocarcinomas.
Author: Della Torre, G|Pasquini, G|Pilotti, S|Alasio, L|Civelli, E|Cozzi, G|Milella, M|Salvetti, M|Pierotti, M A|Severini, A
PMID: 10718212
8.
Journal: Gut. 2000 Nov;47(5):721-7.
Title: Frequency of p16(INK4A) alterations and K-ras mutations in intrahepatic cholangiocarcinoma of the liver.
Author: Tannapfel, A|Benicke, M|Katalinic, A|Uhlmann, D|Kockerling, F|Hauss, J|Wittekind, C
PMID: 11034592
9.
Journal: Clin Cancer Res. 2000 Oct;6(10):4096-100.
Title: Overexpression of retinoblastoma protein predicts decreased survival and correlates with loss of p16INK4 protein in gallbladder carcinomas.
Author: Shi, Y Z|Hui, A M|Li, X|Takayama, T|Makuuchi, M
PMID: 11051262
10.
Journal: Hepatology. 2001 Jan;33(1):43-51.
Title: Involvement of p38 mitogen-activated protein kinase signaling in transformed growth of a cholangiocarcinoma cell line.
Author: Tadlock, L|Patel, T
PMID: 11124819
11.
Journal: Br J Cancer. 2001 Jan;84(2):253-62.
Title: Pancreatic tumours: molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis.
Author: Moore, P S|Orlandini, S|Zamboni, G|Capelli, P|Rigaud, G|Falconi, M|Bassi, C|Lemoine, N R|Scarpa, A
PMID: 11161385
12.
Journal: Oncology. 2001;60(3):242-51.
Title: Expression and clinical significance of the G1-S modulators in intrahepatic cholangiocellular carcinoma.
Author: Ito, Y|Takeda, T|Sasaki, Y|Sakon, M|Yamada, T|Ishiguro, S|Imaoka, S|Tsujimoto, M|Matsuura, N
PMID: 11340376
13.
Journal: Langenbecks Arch Surg. 2001 Apr;386(3):163-71.
Title: Carcinogenesis of cancer of the papilla and ampulla: pathophysiological facts and molecular biological mechanisms.
Author: Esposito, I|Friess, H|Buchler, M W
PMID: 11382316
14.
Journal: Cancer Lett. 2001 Aug 10;169(1):59-68.
Title: Genetic alterations in gallbladder adenoma, dysplasia and carcinoma.
Author: Kim, Y T|Kim, J|Jang, Y H|Lee, W J|Ryu, J K|Park, Y K|Kim, S W|Kim, W H|Yoon, Y B|Kim, C Y
PMID: 11410326
15.
Journal: J Am Coll Surg. 2001 Oct;193(4):380-3.
Title: Association of p53, p16, and vascular endothelial growth factor protein expressions with the prognosis and metastasis of gallbladder cancer.
Author: Quan, Z W|Wu, K|Wang, J|Shi, W|Zhang, Z|Merrell, R C
PMID: 11584965
16.
Journal: Int J Cancer. 2002 Feb 1;97(4):481-8.
Title: Inactivation of the INK4a/ARF locus and p53 in sporadic extrahepatic bile duct cancers and bile tract cancer cell lines.
Author: Caca, Karel|Feisthammel, Jurgen|Klee, Karen|Tannapfel, Andrea|Witzigmann, Helmut|Wittekind, Christian|Mossner, Joachim|Berr, Frieder
PMID: 11802210
17.
Journal: Int J Oncol. 2002 Mar;20(3):453-61.
Title: Down-regulated p16 expression predicts poor prognosis in patients with extrahepatic biliary tract carcinomas.
Author: Ichikawa, K|Imura, J|Kawamata, H|Takeda, J|Fujimori, T
PMID: 11836554
18.
Journal: Br J Cancer. 2002 Jul 15;87(2):187-93.
Title: Establishment and characterisation of six human biliary tract cancer cell lines.
Author: Ku, J-L|Yoon, K-A|Kim, I-J|Kim, W-H|Jang, J-Y|Suh, K-S|Kim, S-W|Park, Y-H|Hwang, J-H|Yoon, Y-B|Park, J-G
PMID: 12107841
19.
Journal: J Pathol. 2002 Aug;197(5):624-31.
Title: Genetic and epigenetic alterations of the INK4a-ARF pathway in cholangiocarcinoma.
Author: Tannapfel, Andrea|Sommerer, Florian|Benicke, Markus|Weinans, Lars|Katalinic, Alexander|Geissler, Felix|Uhlmann, Dirk|Hauss, Johann|Wittekind, Christian
PMID: 12210082
20.
Journal: Am J Pathol. 2002 Sep;161(3):1015-22.
Title: Aberrant CpG island methylation of multiple genes in intrahepatic cholangiocarcinoma.
Author: Lee, Sun|Kim, Woo Ho|Jung, Hwoon-Yong|Yang, Moon Ho|Kang, Gyeong Hoon
PMID: 12213730
21.
Journal: Hepatogastroenterology. 2002 Sep-Oct;49(47):1239-44.
Title: Deregulation of G1/S transition is a common event in carcinoma of the ampulla of vater.
Author: Li, Xin|Hui, Ai-Min|Shi, Ya-Zhou|Sun, Lin|Takayama, Tadatoshi|Makuuchi, Masatoshi
PMID: 12239913
22.
Journal: Gastroenterology. 2002 Oct;123(4):1090-8.
Title: p16INK4a promoter mutations are frequent in primary sclerosing cholangitis (PSC) and PSC-associated cholangiocarcinoma.
Author: Taniai, Makiko|Higuchi, Hajime|Burgart, Lawrence J|Gores, Gregory J
PMID: 12360471
23.
Journal: Hum Pathol. 2002 Sep;33(9):877-83.
Title: Expression of G1-S modulators (p53, p16, p27, cyclin D1, Rb) and Smad4/Dpc4 in intrahepatic cholangiocarcinoma.
Author: Kang, Yun Kyung|Kim, Woo Ho|Jang, Ja June
PMID: 12378511
24.
Journal: Surg Oncol Clin N Am. 2002 Oct;11(4):995-1009.
Title: Cellular and molecular biology of biliary tract cancers.
Author: Rashid, Asif
PMID: 12607585
25.
Journal: Int J Cancer. 2003 Mar 10;104(1):44-53.
Title: Effects of E-cadherin transfection on gene expression of a gallbladder carcinoma cell line: repression of MTS1/S100A4 gene expression.
Author: Kohya, Naohiko|Kitajima, Yoshihiko|Jiao, Wan|Miyazaki, Kohji
PMID: 12532418
26.
Journal: Mol Cancer. 2003 Jan 7;2:7.
Title: Genetic abnormalities in pancreatic cancer.
Author: Moore, Patrick S|Beghelli, Stefania|Zamboni, Giuseppe|Scarpa, Aldo
PMID: 12537585
27.
Journal: Hepatology. 2003 Apr;37(4):852-61.
Title: Homozygous deletion scanning in hepatobiliary tumor cell lines reveals alternative pathways for liver carcinogenesis.
Author: Pineau, Pascal|Marchio, Agnes|Nagamori, Seishi|Seki, Shuichi|Tiollais, Pierre|Dejean, Anne
PMID: 12668978
28.
Journal: Mod Pathol. 2003 Apr;16(4):299-308.
Title: Immunohistochemical and genetic analysis of non-small cell and small cell gallbladder carcinoma and their precursor lesions.
Author: Parwani, Anil V|Geradts, Joseph|Caspers, Eric|Offerhaus, G Johan|Yeo, Charles J|Cameron, John L|Klimstra, David S|Maitra, Anirban|Hruban, Ralph H|Argani, Pedram
PMID: 12692194
29.
Journal: Gastroenterology. 2003 May;124(5):1300-10.
Title: Epigenetic and genetic alterations in duodenal carcinomas are distinct from biliary and ampullary carcinomas.
Author: Kim, Sang Geol|Chan, Annie On-On|Wu, Tsung-Teh|Issa, Jean-Pierre J|Hamilton, Stanley R|Rashid, Asif
PMID: 12730870
30.
Journal: Clin Cancer Res. 2003 May;9(5):1773-8.
Title: Promoter methylation of INK4a/ARF as detected in bile-significance for the differential diagnosis in biliary disease.
Author: Klump, Bodo|Hsieh, Chih-Jen|Dette, Stephan|Holzmann, Karlheinz|Kiebetalich, Ralf|Jung, Michael|Sinn, Udo|Ortner, Marianne|Porschen, Rainer|Gregor, Michael
PMID: 12738733
31.
Journal: Ann Surg Oncol. 2003 Oct;10(8):882-9.
Title: Progression of gene hypermethylation in gallstone disease leading to gallbladder cancer.
Author: House, Michael G|Wistuba, Ignacio I|Argani, Pedram|Guo, MingZhou|Schulick, Richard D|Hruban, Ralph H|Herman, James G|Maitra, Anirban
PMID: 14527906
32.
Journal: J Mol Med (Berl). 2004 Jan;82(1):56-63.
Title: The tumor-selective viral protein apoptin effectively kills human biliary tract cancer cells.
Author: Pietersen, Alexandra M|Rutjes, Saskia A|van Tongeren, Joost|Vogels, Ronald|Wesseling, John G|Noteborn, Mathieu H M
PMID: 14647920
33.
Journal: Clin Cancer Res. 2004 Mar 1;10(5):1717-25.
Title: Alterations of p16 and prognosis in biliary tract cancers from a population-based study in China.
Author: Ueki, Takashi|Hsing, Ann W|Gao, Yu-Tang|Wang, Bing-Sheng|Shen, Ming-Chang|Cheng, Jiarong|Deng, Jie|Fraumeni, Joseph F Jr|Rashid, Asif
PMID: 15014024
34.
Journal: Semin Liver Dis. 2004 May;24(2):139-54.
Title: Serum and bile markers for cholangiocarcinoma.
Author: Nehls, Oliver|Gregor, Michael|Klump, Bodo
PMID: 15192787
35.
Journal: Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6126-33.
Title: Aberrant promoter hypermethylation of multiple genes in gallbladder carcinoma and chronic cholecystitis.
Author: Takahashi, Takao|Shivapurkar, Narayan|Riquelme, Erick|Shigematsu, Hisayuki|Reddy, Jyotsna|Suzuki, Makoto|Miyajima, Kuniharu|Zhou, Xian|Bekele, B Nebiyou|Gazdar, Adi F|Wistuba, Ignacio I
PMID: 15447999
36.
Journal: Cancer Sci. 2004 Sep;95(9):736-40.
Title: Promoter hypermethylation of DAP-kinase is associated with poor survival in primary biliary tract carcinoma patients.
Author: Tozawa, Tomohiro|Tamura, Gen|Honda, Teiichiro|Nawata, Shin-ichi|Kimura, Wataru|Makino, Naohiko|Kawata, Sumio|Sugai, Tamotsu|Suto, Takayuki|Motoyama, Teiichi
PMID: 15471559
37.
Journal: Hum Pathol. 2004 Dec;35(12):1505-14.
Title: Frequent p16ink4a inactivation is an early and frequent event of intraductal papillary neoplasm of the liver arising in hepatolithiasis.
Author: Ishikawa, Akira|Sasaki, Motoko|Sato, Yasunori|Ohira, Shusaku|Chen, Miin-Fu|Huang, Shiu-Feng|Oda, Koji|Nimura, Yuji|Nakanuma, Yasuni
PMID: 15619210
38.
Journal: Rev Med Chil. 2004 Nov;132(11):1369-76.
Title: [Inactivation of CDKN2A gene (p16) in gallbladder carcinoma].
Author: Roa, Juan Carlos|Vo, Quynh|Araya, Juan Carlos|Villaseca, Miguel|Guzman, Pablo|Ibacache, Gilda S|de Aretxabala, Xabier|Roa, Ivan
PMID: 15693199
39.
Journal: Mod Pathol. 2005 Mar;18(3):412-20.
Title: Promoter methylation profiles of tumor suppressor genes in intrahepatic and extrahepatic cholangiocarcinoma.
Author: Yang, Bin|House, Michael G|Guo, Mingzhou|Herman, James G|Clark, Douglas P
PMID: 15467712
40.
Journal: World J Gastroenterol. 2005 Feb 7;11(5):744-7.
Title: Association of cyclin D1, p16 and retinoblastoma protein expressions with prognosis and metastasis of gallbladder carcinoma.
Author: Ma, Hong-Bing|Hu, Hai-Tao|Di, Zheng-Li|Wang, Zuo-Ren|Shi, Jing-Sen|Wang, Xi-Jing|Li, Yi
PMID: 15655836
41.
Journal: Cancer Biol Ther. 2005 Jan;4(1):83-6. Epub 2005 Jan 15.
Title: Homozygous deletion of the MTAP gene in invasive adenocarcinoma of the pancreas and in periampullary cancer: a potential new target for therapy.
Author: Hustinx, Steven R|Hruban, Ralph H|Leoni, Lorenzo M|Iacobuzio-Donahue, Christine|Cameron, John L|Yeo, Charles J|Brown, Priscilla N|Argani, Pedram|Ashfaq, Raheela|Fukushima, Noriyoshi|Goggins, Michael|Kern, Scott E|Maitra, Anirban
PMID: 15662124
42.
Journal: Korean J Gastroenterol. 2005 Mar;45(3):189-94.
Title: [Immunohistochemical study of p53 mutation and p16, p14 alterations encoded by INK4a-ARF in mucin-hypersecreting bile duct tumor].
Author: Kim, Hong Ja|Kim, Myung Hwan|Song, Moon Hee|Song, Dong Eun|Yu, Eunsil
PMID: 15778546
43.
Journal: Hepatogastroenterology. 2005 Jan-Feb;52(61):55-9.
Title: Disruption of pRb-p16INK4 pathway: a common event in ampullary carcinogenesis.
Author: Yuan, Lian-Wen|Tang, Wei|Kokudo, Norihiro|Seyama, Yasujgi|Shi, Ya-Zhou|Karako, Hirona|Zhao, Bin|Sugawara, Yasuhiko|Nagawa, Hirokazu|Makuuchi, Masatoshi
PMID: 15782994
44.
Journal: Ann Surg Oncol. 2005 May;12(5):354-63. Epub 2005 Mar 31.
Title: Tumor progression through epigenetic gene silencing of O(6)-methylguanine-DNA methyltransferase in human biliary tract cancers.
Author: Koga, Yasuo|Kitajima, Yoshihiko|Miyoshi, Atsushi|Sato, Ken|Kitahara, Kenji|Soejima, Hidenobu|Miyazaki, Kohji
PMID: 15915369
45.
Journal: Gynecol Oncol. 2005 Jun;97(3):942-5. Epub 2005 Apr 13.
Title: Metastatic carcinoma of the gallbladder mimicking an advanced cervical carcinoma.
Author: Martinez-Roman, Sergio|Frumovitz, Michael|Deavers, Michael T|Ramirez, Pedro T
PMID: 15943996
46.
Journal: Mol Cancer Ther. 2005 Dec;4(12):1860-6.
Title: Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers.
Author: Karikari, Collins A|Mullendore, Michael|Eshleman, James R|Argani, Pedram|Leoni, Lorenzo M|Chattopadhyay, Shrikanta|Hidalgo, Manuel|Maitra, Anirban
PMID: 16373701
47.
Journal: J Gastroenterol. 2006 Mar;41(3):269-75.
Title: Promoter methylation profile in gallbladder cancer.
Author: Roa, Juan Carlos|Anabalon, Leonardo|Roa, Ivan|Melo, Angelica|Araya, Juan Carlos|Tapia, Oscar|de Aretxabala, Xavier|Munoz, Sergio|Schneider, Barbara
PMID: 16699861
48.
Journal: Dig Surg. 2007;24(1):38-45. Epub 2007 Mar 16.
Title: Long-term survival after radical resection for pancreatic head and ampullary cancer: a potential role for the EGF-R.
Author: Smeenk, H G|Erdmann, J|van Dekken, H|van Marion, R|Hop, W C J|Jeekel, J|van Eijck, C H J
PMID: 17369680
49.
Journal: World J Gastroenterol. 2007 Dec 21;13(47):6396-403.
Title: Two distinct pathways of p16 gene inactivation in gallbladder cancer.
Author: Tadokoro, Hiroyuki|Shigihara, Takako|Ikeda, Tomomi|Takase, Masaru|Suyama, Masafumi
PMID: 18081229
50.
Journal: Pathol Oncol Res. 2007;13(4):326-35. Epub 2007 Dec 25.
Title: Significance of PML and p53 protein as molecular prognostic markers of gallbladder carcinomas.
Author: Chang, Hee Jin|Yoo, Byong Chul|Kim, Sun Whe|Lee, Byung Lan|Kim, Woo Ho
PMID: 18158568
51.
Journal: Hepatology. 2008 Mar;47(3):888-96.
Title: Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma.
Author: Komori, Junji|Marusawa, Hiroyuki|Machimoto, Takafumi|Endo, Yoko|Kinoshita, Kazuo|Kou, Tadayuki|Haga, Hironori|Ikai, Iwao|Uemoto, Shinji|Chiba, Tsutomu
PMID: 18306229
52.
Journal: J Pathol. 2008 Jun;215(2):175-83.
Title: Over-expression of polycomb group protein EZH2 relates to decreased expression of p16 INK4a in cholangiocarcinogenesis in hepatolithiasis.
Author: Sasaki, M|Yamaguchi, J|Itatsu, K|Ikeda, H|Nakanuma, Y
PMID: 18393368
53.
Journal: J Gastrointest Surg. 2008 Oct;12(10):1664-72; discussion 1672-3.
Title: Loss of heterozygosity predicts poor survival after resection of pancreatic adenocarcinoma.
Author: Franko, Jan|Krasinskas, Alyssa M|Nikiforova, Marina N|Zarnescu, Narcis O|Lee, Kenneth K W|Hughes, Steven J|Bartlett, David L|Zeh, Herbert J 3rd|Moser, A James
PMID: 18677542
54.
Journal: Rev Med Chil. 2008 Apr;136(4):451-8.
Title: [Gene methylation patterns in digestive tumors].
Author: Roa S, Juan Carlos|Garcia M, Patricia|Melo A, Angelica|Tapia E, Oscar|Villaseca H, Miguel|Araya O, Juan Carlos|Guzman G, Pablo
PMID: 18769787
55.
Journal: Am J Clin Pathol. 2008 Nov;130(5):780-6.
Title: Clinical significance of cell cycle- and apoptosis-related markers in biliary tract cancer: a tissue microarray-based approach revealing a distinctive immunophenotype for intrahepatic and extrahepatic cholangiocarcinomas.
Author: Karamitopoulou, Eva|Tornillo, Luigi|Zlobec, Inti|Cioccari, Lukas|Carafa, Vincenza|Borner, Markus|Schaffner, Thomas|Brunner, Thomas|Diamantis, Ioannis|Zimmermann, Arthur|Terracciano, Luigi
PMID: 18854271
56.
Journal: Lab Invest. 2009 Sep;89(9):1018-31.
Title: Papillary hyperplasia of the gallbladder in pancreaticobiliary maljunction represents a senescence-related lesion induced by lysolecithin.
Author: Yamaguchi, Junpei|Sasaki, Motoko|Harada, Kenichi|Zen, Yoh|Sato, Yasunori|Ikeda, Hiroko|Itatsu, Keita|Yokoyama, Yukihiro|Ando, Hisami|Ohta, Tetsuo|Kubota, Akio|Shimizu, Koichi|Nimura, Yuji|Nagino, Masato|Nakanuma, Yasuni
PMID: 19564843
57.
Journal: Parasitol Res. 2009 Oct;105(5):1273-81.
Title: Alterations of gene expression of RB pathway in Opisthorchis viverrini infection-induced cholangiocarcinoma.
Author: Boonmars, Thidarut|Wu, Zhiliang|Boonjaruspinyo, Sirintip|Pinlaor, Somchai|Nagano, Isao|Takahashi, Yuzo|Kaewsamut, Butsara|Yongvanit, Puangrat
PMID: 19582476
58.
Journal: J Huazhong Univ Sci Technolog Med Sci. 2009 Dec;29(6):729-31.
Title: Interaction among Rb/p16, Rb/E2F1 and HDAC1 proteins in gallbladder carcinoma.
Author: Wang, Xin|Huang, Kai|Xu, Lining
PMID: 20037816
59.
Journal: World J Hepatol. 2009 Oct 31;1(1):35-42.
Title: Multistep carcinogenesis of perihilar cholangiocarcinoma arising in the intrahepatic large bile ducts.
Author: Nakanuma, Yasuni|Sasaki, Motoko|Sato, Yasunori|Ren, Xiangshan|Ikeda, Hiroko|Harada, Kenichi
PMID: 21160963
60.
Journal: J Hepatobiliary Pancreat Sci. 2010 May;17(3):211-22.
Title: Tumorigenesis and phenotypic characteristics of mucin-producing bile duct tumors: an immunohistochemical approach.
Author: Nakanuma, Yasuni|Zen, Yoh|Harada, Kenichi|Ikeda, Hiroko|Sato, Yasunori|Uehara, Takeshi|Sasaki, Motoko
PMID: 19680592
61.
Journal: Cancer Sci. 2010 Feb;101(2):355-62.
Title: Histone deacetylase inhibitor (SAHA) and repression of EZH2 synergistically inhibit proliferation of gallbladder carcinoma.
Author: Yamaguchi, Junpei|Sasaki, Motoko|Sato, Yasunori|Itatsu, Keita|Harada, Kenichi|Zen, Yoh|Ikeda, Hiroko|Nimura, Yuji|Nagino, Masato|Nakanuma, Yasuni
PMID: 19860841
62.
Journal: Am J Surg. 2010 Apr;199(4):515-21.
Title: Overexpression of LAPTM4B promotes growth of gallbladder carcinoma cells in vitro.
Author: Zhou, Li|He, Xiao-Dong|Yu, Jian-Chun|Zhou, Rou-Li|Yang, Hua|Qu, Qiang|Rui, Jing-An
PMID: 19954766
63.
Journal: Hepatology. 2010 Mar;51(3):881-90.
Title: MicroRNA-dependent regulation of DNA methyltransferase-1 and tumor suppressor gene expression by interleukin-6 in human malignant cholangiocytes.
Author: Braconi, Chiara|Huang, Nianyuan|Patel, Tushar
PMID: 20146264
64.
Journal: Hepatogastroenterology. 2010 Jan-Feb;57(97):18-21.
Title: Expression of p16 protein in gallbladder carcinoma and its precancerous conditions.
Author: Choi, Hye-Jeong|Yun, Sung Su|Kim, Hong Jin|Choi, Joon Hyuk
PMID: 20422865
65.
Journal: Exp Mol Pathol. 2011 Oct;91(2):569-77.
Title: The risk factor of gallbladder cancer: hyperplasia of mucous epithelium caused by gallstones associates with p16/CyclinD1/CDK4 pathway.
Author: Feng, Zhiqiang|Chen, Jinglong|Wei, Honglian|Gao, Ping|Shi, Jingsen|Zhang, Jinqian|Zhao, Fenglin
PMID: 21777578
66.
Journal: Histopathology. 2013 Feb;62(3):446-57.
Title: Overexpression of enhancer of zeste homolog 2 and MUC1 may be related to malignant behaviour in intraductal papillary neoplasm of the bile duct.
Author: Sasaki, Motoko|Matsubara, Takashi|Yoneda, Norihide|Nomoto, Kazuhiro|Tsuneyama, Koichi|Sato, Yasunori|Nakanuma, Yasuni
PMID: 23163606
67.
Journal: Ann Surg Oncol. 2013 Aug;20(8):2511-7.
Title: P16 hypermethylation predicts surgical outcome following curative resection of mid/distal bile duct cancer.
Author: Park, Joon Seong|Park, Young Nyun|Lee, Kang Young|Kim, Jae Keun|Yoon, Dong Sup
PMID: 23478949
68.
Journal: World J Gastroenterol. 2013 Mar 21;19(11):1718-27.
Title: Cancer detection by ubiquitin carboxyl-terminal esterase L1 methylation in pancreatobiliary fluids.
Author: Kato, Norihiro|Yamamoto, Hiroyuki|Adachi, Yasushi|Ohashi, Hirokazu|Taniguchi, Hiroaki|Suzuki, Hiromu|Nakazawa, Mayumi|Kaneto, Hiroyuki|Sasaki, Shigeru|Imai, Kohzoh|Shinomura, Yasuhisa
PMID: 23555160
69.
Journal: Asian Pac J Cancer Prev. 2013;14(5):2711-5.
Title: Cyclin D1, retinoblastoma and p16 protein expression in carcinoma of the gallbladder.
Author: Srivastava, Vineeta|Patel, Brijesh|Kumar, Mohan|Shukla, Mridula|Pandey, Manoj
PMID: 23803020
70.
Journal: Hum Pathol. 2013 Oct;44(10):2173-9.
Title: An extended fluorescence in situ hybridization approach for the cytogenetic study of cholangiocarcinoma on endoscopic retrograde cholangiopancreatography brushing cytology preparations.
Author: Vasilieva, Larisa E|Papadhimitriou, Stefanos I|Alexopoulou, Alexandra|Pavlidis, Dimitris|Kostopoulos, Ioannis|Georgiakaki, Maria|Xinopoulos, Dimitrios|Romanos, Andreas|Dourakis, Spyridon P
PMID: 23845469
71.
Journal: Ann Surg Oncol. 2013 Dec;20 Suppl 3:S667-75.
Title: Enhancer of zeste homolog 2 (EZH2) promotes progression of cholangiocarcinoma cells by regulating cell cycle and apoptosis.
Author: Nakagawa, Shigeki|Okabe, Hirohisa|Sakamoto, Yasuo|Hayashi, Hiromitsu|Hashimoto, Daisuke|Yokoyama, Naomi|Sakamoto, Keita|Kuroki, Hideyuki|Mima, Kosuke|Nitta, Hidetoshi|Imai, Katsunori|Chikamoto, Akira|Watanabe, Masayuki|Beppu, Toru|Baba, Hideo
PMID: 23887863
72.
Journal: PLoS One. 2013 Dec 13;8(12):e82426.
Title: Mutation inactivation of Nijmegen breakage syndrome gene (NBS1) in hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
Author: Wang, Yan|Hong, Yu|Li, Man|Long, Jiang|Zhao, Yan-Ping|Zhang, Jun-Xia|Li, Qian|You, Hong|Tong, Wei-Min|Jia, Ji-Dong|Huang, Jian
PMID: 24349281
73.
Journal: Mod Pathol. 2014 Jan;27(1):73-86.
Title: Intraductal papillary neoplasms of the bile duct: stepwise progression to carcinoma involves common molecular pathways.
Author: Schlitter, Anna Melissa|Born, Diana|Bettstetter, Marcus|Specht, Katja|Kim-Fuchs, Corina|Riener, Marc-Oliver|Jeliazkova, Petia|Sipos, Bence|Siveke, Jens T|Terris, Benoit|Zen, Yoh|Schuster, Tibor|Hofler, Heinz|Perren, Aurel|Kloppel, Gunter|Esposito, Irene
PMID: 23828315
74.
Journal: Ann Surg Oncol. 2014 Feb;21(2):487-500.
Title: Prognostic biomarkers in patients with resected cholangiocarcinoma: a systematic review and meta-analysis.
Author: Ruys, Anthony T|Groot Koerkamp, Bas|Wiggers, Jimme K|Klumpen, Heinz-Josef|ten Kate, Fiebo J|van Gulik, Thomas M
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Journal: Tumour Biol. 2014 Feb;35(2):1417-26.
Title: BCL6 overexpression is associated with decreased p19 ARF expression and confers an independent prognosticator in gallbladder carcinoma.
Author: Liang, Peir-In|Li, Chien-Feng|Chen, Li-Tzong|Sun, Ding-Ping|Chen, Tzu-Ju|Hsing, Chung-Hsi|Hsu, Han-Ping|Lin, Ching-Yih
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Journal: Pathol Oncol Res. 2014 Apr;20(2):409-15.
Title: Expression of cell cycle-related proteins, p16, p53 and p63 as important prognostic markers in gallbladder adenocarcinoma.
Author: Kim, Kyungeun|Kim, Dong-Hoon|Chae, Seoung Wan|Shin, Jun-Ho|Kim, Hong Joo|Do, Sung-Im|Lee, Hyun Joo|Koo, Ji Hae|Pyo, Jung-Soo|Sohn, Jin Hee
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Journal: Mod Pathol. 2014 May;27(5):731-9.
Title: High throughput molecular profiling reveals differential mutation patterns in intrahepatic cholangiocarcinomas arising in chronic advanced liver diseases.
Author: Jang, Sejin|Chun, Sung-Min|Hong, Seoung-Mo|Sung, Chang Ohk|Park, Hosub|Kang, Hyo Jeong|Kim, Kyu-pyo|Lee, Young Joo|Yu, Eunsil
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Journal: Oncol Rep. 2014 Feb;31(2):983-8.
Title: Epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A inhibits the growth of cholangiocarcinoma cells.
Author: Nakagawa, Shigeki|Sakamoto, Yasuo|Okabe, Hirohisa|Hayashi, Hiromitsu|Hashimoto, Daisuke|Yokoyama, Naomi|Tokunaga, Ryuma|Sakamoto, Keita|Kuroki, Hideyuki|Mima, Kosuke|Beppu, Toru|Baba, Hideo
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Journal: Clin Res Hepatol Gastroenterol. 2014 Apr;38(2):181-9.
Title: si-DNMT1 restore tumor suppressor genes expression through the reversal of DNA hypermethylation in cholangiocarcinoma.
Author: Xiang, Jifeng|Luo, Fang|Chen, Yong|Zhu, Fangyu|Wang, Jiming
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Journal: Am J Surg Pathol. 2014 Mar;38(3):364-9.
Title: Immunostaining for polycomb group protein EZH2 and senescent marker p16INK4a may be useful to differentiate cholangiolocellular carcinoma from ductular reaction and bile duct adenoma.
Author: Sasaki, Motoko|Matsubara, Takashi|Kakuda, Yuko|Sato, Yasunori|Nakanuma, Yasuni
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Journal: J Hepatobiliary Pancreat Sci. 2014 Jun;21(6):380-7.
Title: Genomic and transcriptional alterations of cholangiocarcinoma.
Author: Ito, Takeshi|Sakurai-Yageta, Mika|Goto, Akiteru|Pairojkul, Chawalit|Yongvanit, Puangrat|Murakami, Yoshinori
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Journal: Oncologist. 2014 Mar;19(3):235-42.
Title: New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing.
Author: Ross, Jeffrey S|Wang, Kai|Gay, Laurie|Al-Rohil, Rami|Rand, Janne V|Jones, David M|Lee, Hwa J|Sheehan, Christine E|Otto, Geoff A|Palmer, Gary|Yelensky, Roman|Lipson, Doron|Morosini, Deborah|Hawryluk, Matthew|Catenacci, Daniel V T|Miller, Vincent A|Churi, C
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Journal: Ann Surg. 2014 Dec;260(6):1073-80.
Title: Sequential occurrence of preneoplastic lesions and accumulation of loss of heterozygosity in patients with gallbladder stones suggest causal association with gallbladder cancer.
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Journal: J Hepatobiliary Pancreat Sci. 2014 Oct;21(10):754-60.
Title: Molecular mechanism of cholangiocarcinoma carcinogenesis.
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Journal: Oncologist. 2014 Jul;19(7):760-5.
Title: 6-thioguanine: a drug with unrealized potential for cancer therapy.
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Journal: Hum Pathol. 2014 Nov;45(11):2334-40.
Title: High-mobility group AT-hook 2: an independent marker of poor prognosis in intrahepatic cholangiocarcinoma.
Author: Lee, Chung-Ta|Wu, Tsung-Teh|Lohse, Christine M|Zhang, Lizhi
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Journal: PLoS One. 2014 Dec 23;9(12):e115383.
Title: Mutation profiling in cholangiocarcinoma: prognostic and therapeutic implications.
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Journal: Future Oncol. 2015;11(2):233-49.
Title: Global and gene-specific DNA methylation pattern discriminates cholecystitis from gallbladder cancer patients in Chile.
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Journal: Histol Histopathol. 2015 Mar;30(3):267-75.
Title: Cellular senescence in biliary pathology. Special emphasis on expression of a polycomb group protein EZH2 and a senescent marker p16INK4a in bile ductular tumors and lesions.
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Journal: J Clin Pathol. 2015 Apr;68(4):283-7.
Title: A multistep cytological approach for patients with jaundice and biliary strictures of indeterminate origin.
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Journal: Appl Immunohistochem Mol Morphol. 2015 Oct;23(9):607-14.
Title: Malignant Transformation in Von-Meyenburg Complexes: Histologic and Immunohistochemical Clues With Illustrative Cases.
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Journal: Mod Pathol. 2015 Aug;28(8):1123-9.
Title: Sequencing of 279 cancer genes in ampullary carcinoma reveals trends relating to histologic subtypes and frequent amplification and overexpression of ERBB2 (HER2).
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Journal: Mod Pathol. 2015 Sep;28(9):1249-64.
Title: Intraductal tubulopapillary neoplasms of the bile ducts: clinicopathologic, immunohistochemical, and molecular analysis of 20 cases.
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Journal: Biomark Med. 2015;9(8):763-75.
Title: Prognostic molecular markers in resected extrahepatic biliary tract cancers; a systematic review and meta-analysis of immunohistochemically detected biomarkers.
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Journal: Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13982-7.
Title: CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice.
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Journal: Int J Clin Exp Pathol. 2015 Sep 1;8(9):11440-5. eCollection 2015.
Title: High DBC1 (CCAR2) expression in gallbladder carcinoma is associated with favorable clinicopathological factors.
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Journal: Tumour Biol. 2016 Jul;37(7):9875-86.
Title: Expression and mechanisms of long non-coding RNA genes MEG3 and ANRIL in gallbladder cancer.
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Journal: Cancer Metastasis Rev. 2016 Jun;35(2):263-75.
Title: Genomics of gallbladder cancer: the case for biomarker-driven clinical trial design.
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Journal: Zhonghua Wai Ke Za Zhi. 2016 Mar 1;54(3):222-7.
Title: [Artemisinin inhibits proliferation of gallbladder cancer cell lines through triggering cell cycle arrest and apoptosis].
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Journal: Oncotarget. 2016 Apr 26;7(17):23825-36.
Title: Two classes of intrahepatic cholangiocarcinoma defined by relative abundance of mutations and copy number alterations.
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Journal: Mol Med Rep. 2016 May;13(5):4461-8.
Title: Artemisinin inhibits gallbladder cancer cell lines through triggering cell cycle arrest and apoptosis.
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Journal: Cancer. 2016 Dec 1;122(23):3657-3666.
Title: Next-generation sequencing survey of biliary tract cancer reveals the association between tumor somatic variants and chemotherapy resistance.
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Title: Biliary cancer: Utility of next-generation sequencing for clinical management.
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Journal: Crit Rev Oncol Hematol. 2016 Nov;107:111-118.
Title: Molecular characteristics of biliary tract cancer.
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Journal: J Invest Dermatol. 2017 Feb;137(2):494-505.
Title: Elevated DeltaNp63alpha Levels Facilitate Epidermal and Biliary Oncogenic Transformation.
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Journal: Int J Mol Sci. 2017 May 23;18(6). pii: ijms18061111.
Title: Aberrant DNA Methylation as a Biomarker and a Therapeutic Target of Cholangiocarcinoma.
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Journal: Oncol Lett. 2017 Aug;14(2):1265-1274.
Title: Cul4B is a novel prognostic marker in cholangiocarcinoma.
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Title: DNA Methylation Markers Improve the Sensitivity of Endoscopic Retrograde Cholangiopancreatography-Based Brushing Cytology in Extrahepatic Cholangiocarcinoma.
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Journal: Future Oncol. 2018 Mar;14(6):553-566.
Title: Novel targeted therapy strategies for biliary tract cancers and hepatocellular carcinoma.
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Journal: J Gastrointest Oncol. 2018 Feb;9(1):111-125.
Title: Investigation of targetable predictive and prognostic markers in gallbladder carcinoma.
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Journal: Clin Cancer Res. 2018 Sep 1;24(17):4154-4161.
Title: Comprehensive Molecular Profiling of Intrahepatic and Extrahepatic Cholangiocarcinomas: Potential Targets for Intervention.
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Title: The Role of Next Generation Sequencing in the Differential Diagnosis of Composite Neoplasms.
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