Primary Site >> Biliary tract Cancer
Gene >> CDKN2A
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Ref: Mutations of p16Ink4/CDKN2 and p15Ink4B/MTS2 genes in biliary tract cancers. PMID: 7796400 |
Ref: Frequency of mutation and deletion of the tumor suppressor gene CDKN2A (MTS1/p16) in hepatocellular carcinoma from an Australian population. PMID: 9049204 |
Ref: Gallbladder adenomas have molecular abnormalities different from those present in gallbladder carcinomas. PMID: 9923922 Ref: Chromosome 9p21 loss and p16 inactivation in primary sclerosing cholangitis-associated cholangiocarcinoma. PMID: 10334895 Ref: Biliopancreatic malignancy: screening the at risk patient with molecular markers. PMID: 10436811 Ref: Genetic abnormalities involved in the pathogenesis of gallbladder carcinoma. PMID: 10526058 |
Ref: TP53 mutations and mdm2 protein overexpression in cholangiocarcinomas. PMID: 10718212 Ref: Frequency of p16(INK4A) alterations and K-ras mutations in intrahepatic cholangiocarcinoma of the liver. PMID: 11034592 Ref: Overexpression of retinoblastoma protein predicts decreased survival and correlates with loss of p16INK4 protein in gallbladder carcinomas. PMID: 11051262 |
Ref: Involvement of p38 mitogen-activated protein kinase signaling in transformed growth of a cholangiocarcinoma cell line. PMID: 11124819 Ref: Pancreatic tumours: molecular pathways implicated in ductal cancer are involved in ampullary but not in exocrine nonductal or endocrine tumorigenesis. PMID: 11161385 Ref: Expression and clinical significance of the G1-S modulators in intrahepatic cholangiocellular carcinoma. PMID: 11340376 Ref: Carcinogenesis of cancer of the papilla and ampulla: pathophysiological facts and molecular biological mechanisms. PMID: 11382316 Ref: Genetic alterations in gallbladder adenoma, dysplasia and carcinoma. PMID: 11410326 Ref: Association of p53, p16, and vascular endothelial growth factor protein expressions with the prognosis and metastasis of gallbladder cancer. PMID: 11584965 |
Ref: Inactivation of the INK4a/ARF locus and p53 in sporadic extrahepatic bile duct cancers and bile tract cancer cell lines. PMID: 11802210 Ref: Down-regulated p16 expression predicts poor prognosis in patients with extrahepatic biliary tract carcinomas. PMID: 11836554 Ref: Establishment and characterisation of six human biliary tract cancer cell lines. PMID: 12107841 Ref: Genetic and epigenetic alterations of the INK4a-ARF pathway in cholangiocarcinoma. PMID: 12210082 Ref: Aberrant CpG island methylation of multiple genes in intrahepatic cholangiocarcinoma. PMID: 12213730 Ref: Deregulation of G1/S transition is a common event in carcinoma of the ampulla of vater. PMID: 12239913 Ref: p16INK4a promoter mutations are frequent in primary sclerosing cholangitis (PSC) and PSC-associated cholangiocarcinoma. PMID: 12360471 Ref: Expression of G1-S modulators (p53, p16, p27, cyclin D1, Rb) and Smad4/Dpc4 in intrahepatic cholangiocarcinoma. PMID: 12378511 Ref: Cellular and molecular biology of biliary tract cancers. PMID: 12607585 |
Ref: Effects of E-cadherin transfection on gene expression of a gallbladder carcinoma cell line: repression of MTS1/S100A4 gene expression. PMID: 12532418 Ref: Genetic abnormalities in pancreatic cancer. PMID: 12537585 Ref: Homozygous deletion scanning in hepatobiliary tumor cell lines reveals alternative pathways for liver carcinogenesis. PMID: 12668978 Ref: Immunohistochemical and genetic analysis of non-small cell and small cell gallbladder carcinoma and their precursor lesions. PMID: 12692194 Ref: Epigenetic and genetic alterations in duodenal carcinomas are distinct from biliary and ampullary carcinomas. PMID: 12730870 Ref: Promoter methylation of INK4a/ARF as detected in bile-significance for the differential diagnosis in biliary disease. PMID: 12738733 Ref: Progression of gene hypermethylation in gallstone disease leading to gallbladder cancer. PMID: 14527906 |
Ref: The tumor-selective viral protein apoptin effectively kills human biliary tract cancer cells. PMID: 14647920 Ref: Alterations of p16 and prognosis in biliary tract cancers from a population-based study in China. PMID: 15014024 Ref: Serum and bile markers for cholangiocarcinoma. PMID: 15192787 Ref: Aberrant promoter hypermethylation of multiple genes in gallbladder carcinoma and chronic cholecystitis. PMID: 15447999 Ref: Promoter hypermethylation of DAP-kinase is associated with poor survival in primary biliary tract carcinoma patients. PMID: 15471559 Ref: Frequent p16ink4a inactivation is an early and frequent event of intraductal papillary neoplasm of the liver arising in hepatolithiasis. PMID: 15619210 Ref: [Inactivation of CDKN2A gene (p16) in gallbladder carcinoma]. PMID: 15693199 |
Ref: Promoter methylation profiles of tumor suppressor genes in intrahepatic and extrahepatic cholangiocarcinoma. PMID: 15467712 Ref: Association of cyclin D1, p16 and retinoblastoma protein expressions with prognosis and metastasis of gallbladder carcinoma. PMID: 15655836 Ref: Homozygous deletion of the MTAP gene in invasive adenocarcinoma of the pancreas and in periampullary cancer: a potential new target for therapy. PMID: 15662124 Ref: [Immunohistochemical study of p53 mutation and p16, p14 alterations encoded by INK4a-ARF in mucin-hypersecreting bile duct tumor]. PMID: 15778546 Ref: Disruption of pRb-p16INK4 pathway: a common event in ampullary carcinogenesis. PMID: 15782994 Ref: Tumor progression through epigenetic gene silencing of O(6)-methylguanine-DNA methyltransferase in human biliary tract cancers. PMID: 15915369 Ref: Metastatic carcinoma of the gallbladder mimicking an advanced cervical carcinoma. PMID: 15943996 Ref: Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers. PMID: 16373701 |
Ref: Promoter methylation profile in gallbladder cancer. PMID: 16699861 |
Ref: Long-term survival after radical resection for pancreatic head and ampullary cancer: a potential role for the EGF-R. PMID: 17369680 Ref: Two distinct pathways of p16 gene inactivation in gallbladder cancer. PMID: 18081229 Ref: Significance of PML and p53 protein as molecular prognostic markers of gallbladder carcinomas. PMID: 18158568 |
Ref: Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma. PMID: 18306229 Ref: Over-expression of polycomb group protein EZH2 relates to decreased expression of p16 INK4a in cholangiocarcinogenesis in hepatolithiasis. PMID: 18393368 Ref: Loss of heterozygosity predicts poor survival after resection of pancreatic adenocarcinoma. PMID: 18677542 Ref: [Gene methylation patterns in digestive tumors]. PMID: 18769787 Ref: Clinical significance of cell cycle- and apoptosis-related markers in biliary tract cancer: a tissue microarray-based approach revealing a distinctive immunophenotype for intrahepatic and extrahepatic cholangiocarcinomas. PMID: 18854271 |
Ref: Papillary hyperplasia of the gallbladder in pancreaticobiliary maljunction represents a senescence-related lesion induced by lysolecithin. PMID: 19564843 Ref: Alterations of gene expression of RB pathway in Opisthorchis viverrini infection-induced cholangiocarcinoma. PMID: 19582476 Ref: Interaction among Rb/p16, Rb/E2F1 and HDAC1 proteins in gallbladder carcinoma. PMID: 20037816 Ref: Multistep carcinogenesis of perihilar cholangiocarcinoma arising in the intrahepatic large bile ducts. PMID: 21160963 |
Ref: Tumorigenesis and phenotypic characteristics of mucin-producing bile duct tumors: an immunohistochemical approach. PMID: 19680592 Ref: Histone deacetylase inhibitor (SAHA) and repression of EZH2 synergistically inhibit proliferation of gallbladder carcinoma. PMID: 19860841 Ref: Overexpression of LAPTM4B promotes growth of gallbladder carcinoma cells in vitro. PMID: 19954766 Ref: MicroRNA-dependent regulation of DNA methyltransferase-1 and tumor suppressor gene expression by interleukin-6 in human malignant cholangiocytes. PMID: 20146264 Ref: Expression of p16 protein in gallbladder carcinoma and its precancerous conditions. PMID: 20422865 |
Ref: The risk factor of gallbladder cancer: hyperplasia of mucous epithelium caused by gallstones associates with p16/CyclinD1/CDK4 pathway. PMID: 21777578 |
Ref: Overexpression of enhancer of zeste homolog 2 and MUC1 may be related to malignant behaviour in intraductal papillary neoplasm of the bile duct. PMID: 23163606 Ref: P16 hypermethylation predicts surgical outcome following curative resection of mid/distal bile duct cancer. PMID: 23478949 Ref: Cancer detection by ubiquitin carboxyl-terminal esterase L1 methylation in pancreatobiliary fluids. PMID: 23555160 Ref: Cyclin D1, retinoblastoma and p16 protein expression in carcinoma of the gallbladder. PMID: 23803020 Ref: An extended fluorescence in situ hybridization approach for the cytogenetic study of cholangiocarcinoma on endoscopic retrograde cholangiopancreatography brushing cytology preparations. PMID: 23845469 Ref: Enhancer of zeste homolog 2 (EZH2) promotes progression of cholangiocarcinoma cells by regulating cell cycle and apoptosis. PMID: 23887863 Ref: Mutation inactivation of Nijmegen breakage syndrome gene (NBS1) in hepatocellular carcinoma and intrahepatic cholangiocarcinoma. PMID: 24349281 |
Ref: Intraductal papillary neoplasms of the bile duct: stepwise progression to carcinoma involves common molecular pathways. PMID: 23828315 Ref: Prognostic biomarkers in patients with resected cholangiocarcinoma: a systematic review and meta-analysis. PMID: 24081803 Ref: BCL6 overexpression is associated with decreased p19 ARF expression and confers an independent prognosticator in gallbladder carcinoma. PMID: 24114011 Ref: Expression of cell cycle-related proteins, p16, p53 and p63 as important prognostic markers in gallbladder adenocarcinoma. PMID: 24178677 Ref: High throughput molecular profiling reveals differential mutation patterns in intrahepatic cholangiocarcinomas arising in chronic advanced liver diseases. PMID: 24186137 Ref: Epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A inhibits the growth of cholangiocarcinoma cells. PMID: 24337160 Ref: si-DNMT1 restore tumor suppressor genes expression through the reversal of DNA hypermethylation in cholangiocarcinoma. PMID: 24361215 Ref: Immunostaining for polycomb group protein EZH2 and senescent marker p16INK4a may be useful to differentiate cholangiolocellular carcinoma from ductular reaction and bile duct adenoma. PMID: 24487593 Ref: Genomic and transcriptional alterations of cholangiocarcinoma. PMID: 24532422 Ref: New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing. PMID: 24563076 Ref: Sequential occurrence of preneoplastic lesions and accumulation of loss of heterozygosity in patients with gallbladder stones suggest causal association with gallbladder cancer. PMID: 24827397 Ref: Molecular mechanism of cholangiocarcinoma carcinogenesis. PMID: 24895231 Ref: 6-thioguanine: a drug with unrealized potential for cancer therapy. PMID: 24928612 Ref: High-mobility group AT-hook 2: an independent marker of poor prognosis in intrahepatic cholangiocarcinoma. PMID: 25245603 Ref: Mutation profiling in cholangiocarcinoma: prognostic and therapeutic implications. PMID: 25536104 |
Ref: Global and gene-specific DNA methylation pattern discriminates cholecystitis from gallbladder cancer patients in Chile. PMID: 25066711 Ref: Cellular senescence in biliary pathology. Special emphasis on expression of a polycomb group protein EZH2 and a senescent marker p16INK4a in bile ductular tumors and lesions. PMID: 25289642 Ref: A multistep cytological approach for patients with jaundice and biliary strictures of indeterminate origin. PMID: 25681513 Ref: Malignant Transformation in Von-Meyenburg Complexes: Histologic and Immunohistochemical Clues With Illustrative Cases. PMID: 25789533 Ref: Sequencing of 279 cancer genes in ampullary carcinoma reveals trends relating to histologic subtypes and frequent amplification and overexpression of ERBB2 (HER2). PMID: 25975284 Ref: Intraductal tubulopapillary neoplasms of the bile ducts: clinicopathologic, immunohistochemical, and molecular analysis of 20 cases. PMID: 26111977 Ref: Prognostic molecular markers in resected extrahepatic biliary tract cancers; a systematic review and meta-analysis of immunohistochemically detected biomarkers. PMID: 26223884 Ref: CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice. PMID: 26508638 Ref: High DBC1 (CCAR2) expression in gallbladder carcinoma is associated with favorable clinicopathological factors. PMID: 26617872 |
Ref: Expression and mechanisms of long non-coding RNA genes MEG3 and ANRIL in gallbladder cancer. PMID: 26812694 Ref: Genomics of gallbladder cancer: the case for biomarker-driven clinical trial design. PMID: 26857926 Ref: [Artemisinin inhibits proliferation of gallbladder cancer cell lines through triggering cell cycle arrest and apoptosis]. PMID: 26932893 Ref: Two classes of intrahepatic cholangiocarcinoma defined by relative abundance of mutations and copy number alterations. PMID: 27009864 Ref: Artemisinin inhibits gallbladder cancer cell lines through triggering cell cycle arrest and apoptosis. PMID: 27035431 Ref: Next-generation sequencing survey of biliary tract cancer reveals the association between tumor somatic variants and chemotherapy resistance. PMID: 27495988 Ref: Biliary cancer: Utility of next-generation sequencing for clinical management. PMID: 27622582 Ref: Molecular characteristics of biliary tract cancer. PMID: 27823638 |
Ref: Elevated DeltaNp63alpha Levels Facilitate Epidermal and Biliary Oncogenic Transformation. PMID: 27725202 Ref: Aberrant DNA Methylation as a Biomarker and a Therapeutic Target of Cholangiocarcinoma. PMID: 28545228 Ref: Cul4B is a novel prognostic marker in cholangiocarcinoma. PMID: 28808481 Ref: DNA Methylation Markers Improve the Sensitivity of Endoscopic Retrograde Cholangiopancreatography-Based Brushing Cytology in Extrahepatic Cholangiocarcinoma. PMID: 29484968 |
Ref: Novel targeted therapy strategies for biliary tract cancers and hepatocellular carcinoma. PMID: 29460642 Ref: Investigation of targetable predictive and prognostic markers in gallbladder carcinoma. PMID: 29564177 Ref: Comprehensive Molecular Profiling of Intrahepatic and Extrahepatic Cholangiocarcinomas: Potential Targets for Intervention. PMID: 29848569 Ref: The Role of Next Generation Sequencing in the Differential Diagnosis of Composite Neoplasms. PMID: 29958927 |