Primary Site >> Esophagus Cancer

Gene >> CDKN1A

Journal: Nihon Rinsho. 1996 Apr;54(4):965-71.
Title: [RB gene expression in gastrointestinal tract].
Author: Monden, T|Yamamoto, H|Ikeda, K|Izawa, H|Tsujie, M|Ohnishi, T|Miyoshi, Y|Sekimoto, M|Tomita, N|Monden, M
PMID: 8920658
Journal: Adv Exp Med Biol. 1997;407:41-53.
Title: Involvement of the multiple tumor suppressor genes and 12-lipoxygenase in human prostate cancer. Therapeutic implications.
Author: Gao, X|Porter, A T|Honn, K V
PMID: 9321930
Journal: Int J Oncol. 1997 Oct;11(4):703-8.
Title: Correlation between reduced p21(WAF1/CIP1) expression and abnormal p53 expression in esophageal carcinomas.
Author: Toh, Y|Kuwano, H|Sonoda, K|Saeki, H|Kawaguchi, H|Kitamura, K|Nakashima, H|Sugimachi, K
PMID: 21528264
Journal: Dig Dis Sci. 1998 Feb;43(2):279-89.
Title: Expression of p53 and p21WAF1/CIP1 proteins in gastric and esophageal cancers: comparison with mutations of the p53 gene.
Author: Seta, T|Imazeki, F|Yokosuka, O|Saisho, H|Suzuki, T|Koide, Y|Isono, K
PMID: 9512119
Journal: Mol Carcinog. 1998 Mar;21(3):185-93.
Title: Alterations in the expression of alpha6beta4 integrin and p21/WAF1/Cip1 in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis.
Author: Khare, L|Sabourin, C L|DeYoung, B R|Wagner, B A|Stoner, G D
PMID: 9537650
Journal: Hepatogastroenterology. 1998 Sep-Oct;45(23):1497-504.
Title: Expression and alteration of p53 and p21(waf1/cip1) influence the sensitivity of chemoradiation therapy for esophageal cancer.
Author: Shimoyama, S|Konishi, T|Kawahara, M|Aoki, F|Harada, N|Shimizu, S|Murakami, T|Kaminishi, M
PMID: 9840093
Journal: Histol Histopathol. 1999 Apr;14(2):479-85.
Title: Immunohistochemical analysis for cell proliferation-related protein expression in small cell carcinoma of the esophagus; a comparative study with small cell carcinoma of the lung and squamous cell carcinoma of the esophagus.
Author: Okudela, K|Ito, T|Kameda, Y|Nakamura, N|Kitamura, H
PMID: 10212809
Journal: Cancer. 1999 Sep 1;86(5):756-63.
Title: Expression of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) and p53 tumor suppressor in dysplastic progression and adenocarcinoma in Barrett esophagus.
Author: Hanas, J S|Lerner, M R|Lightfoot, S A|Raczkowski, C|Kastens, D J|Brackett, D J|Postier, R G
PMID: 10463972
Journal: Dis Esophagus. 1999;12(2):116-9.
Title: p53, p21(Waf1/Cip1) and cyclin D1 protein expression and prognosis in esophageal cancer.
Author: Kuwahara, M|Hirai, T|Yoshida, K|Yamashita, Y|Hihara, J|Inoue, H|Toge, T
PMID: 10466043
Journal: Clin Cancer Res. 1999 Sep;5(9):2445-9.
Title: Expression of p21WAF1/Cip1 in the p53-dependent pathway is related to prognosis in patients with advanced esophageal carcinoma.
Author: Natsugoe, S|Nakashima, S|Matsumoto, M|Xiangming, C|Okumura, H|Kijima, F|Ishigami, S|Takebayashi, Y|Baba, M|Takao, S|Aikou, T
PMID: 10499617
Journal: Anticancer Res. 1999 Sep-Oct;19(5C):4587-91.
Title: The prognostic significance of p53, p21 (Waf1/Cip1), and cyclin D1 protein expression in esophageal cancer patients.
Author: Hirai, T|Kuwahara, M|Yoshida, K|Osaki, A|Toge, T
PMID: 10650815
Journal: Oncogene. 2000 Jan 20;19(3):323-8.
Title: Novel polymorphism in p21(waf1/cip1) cyclin dependent kinase inhibitor gene: association with human esophageal cancer.
Author: Bahl, R|Arora, S|Nath, N|Mathur, M|Shukla, N K|Ralhan, R
PMID: 10656678
Journal: Ann Surg Oncol. 2000 Apr;7(3):204-9.
Title: Biological evaluation of undifferentiated carcinoma of the esophagus.
Author: Matsumoto, M|Natsugoe, S|Nakashima, S|Shimada, M|Nakano, S|Kusano, C|Baba, M|Takao, S|Matsushita, Y|Aikou, T
PMID: 10791851
Journal: Clin Cancer Res. 2000 Jun;6(6):2440-7.
Title: Association between polymorphism in p21(Waf1/Cip1) cyclin-dependent kinase inhibitor gene and human oral cancer.
Author: Ralhan, R|Agarwal, S|Mathur, M|Wasylyk, B|Srivastava, A
PMID: 10873097
Journal: Ann Surg Oncol. 2001 Aug;8(7):598-604.
Title: Clinical significance and prognostic value of apoptosis related proteins in superficial esophageal squamous cell carcinoma.
Author: Matsumoto, M|Natsugoe, S|Nakashima, S|Okumura, H|Sakita, H|Baba, M|Takao, S|Aikou, T
PMID: 11508622
Journal: Gan To Kagaku Ryoho. 2001 Oct;28(11):1651-4.
Title: [Experimental gene therapy using p21/WAF1 gene in esophageal squamous cell carcinoma--adenovirus infection and gene gun technology].
Author: Fujii, T|Tanaka, Y|Tanaka, T|Matono, S|Sueyoshi, S|Fujita, H|Shirouzu, K|Kato, S|Yamana, H
PMID: 11708000
Journal: Oncogene. 2001 Jan 25;20(4):484-9.
Title: p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues.
Author: Yu, P|Huang, B|Shen, M|Lau, C|Chan, E|Michel, J|Xiong, Y|Payan, D G|Luo, Y
PMID: 11313979
Journal: J Lab Clin Med. 2002 Jul;140(1):17-26.
Title: Growth inhibition of esophageal squamous carcinoma cells by peroxisome proliferator-activated receptor-gamma ligands.
Author: Rumi, Mohammad Azharul Karim|Sato, Hiroshi|Ishihara, Shunji|Ortega, Cesar|Kadowaki, Yasunori|Kinoshita, Yoshikazu
PMID: 12080324
Journal: J Gastroenterol. 2002;37(7):497-503.
Title: Epidermal growth factor inhibits the growth of TE8 esophageal cancer cells through the activation of STAT1.
Author: Ichiba, Makoto|Miyazaki, Yoshiji|Kitamura, Shinji|Kiyohara, Tatsuya|Shinomura, Yasuhisa|Matsuzawa, Yuji
PMID: 12162406
Journal: Hum Gene Ther. 2002 Jul 20;13(11):1373-82.
Title: Adenovirus-mediated p14ARF gene transfer cooperates with Ad5CMV-p53 to induce apoptosis in human cancer cells.
Author: Tango, Yasuhisa|Fujiwara, Toshiyoshi|Itoshima, Takahiro|Takata, Yoshiko|Katsuda, Kou|Uno, Futoshi|Ohtani, Shoichiro|Tani, Tohru|Roth, Jack A|Tanaka, Noriaki
PMID: 12162819
Journal: Int J Oncol. 2002 Sep;21(3):547-52.
Title: Molecular and genetic characterization of a non-metastatic human esophageal cancer cell line, T.Tn expressing non-functional mutated p53.
Author: Sakai, Taro|Furihata, Tadashi|Kawamata, Hitoshi|Omotehara, Fumie|Shinagawa, Yasuhiro|Imura, Johji|Kubota, Keiichi|Terano, Akira|Fujimori, Takahiro
PMID: 12168098
Journal: Oncogene. 2002 Oct 31;21(50):7745-8.
Title: Esophageal cancer in Chinese population: no polymorphism in codon 149 of P21(Waf1/Cip1) cyclin dependent kinase gene.
Author: Xi, Ya-Guang|Ding, Ke-Yue|Ren, Ying-Hui|Shen, Yan|Ke, Yang
PMID: 12400017
Journal: J Thorac Cardiovasc Surg. 2003 May;125(5):1132-42.
Title: Enhancement of depsipeptide-mediated apoptosis of lung or esophageal cancer cells by flavopiridol: activation of the mitochondria-dependent death-signaling pathway.
Author: Nguyen, Dao M|Schrump, William D|Tsai, Wilson S|Chen, Aaron|Stewart, John H 4th|Steiner, Federico|Schrump, David S
PMID: 12771887
Journal: J Exp Clin Cancer Res. 2003 Jun;22(2):239-45.
Title: Prediction of lymph node metastasis by p53, p21(Waf1), and PCNA expression in esophageal cancer patients.
Author: Ueno, H|Hirai, T|Nishimoto, N|Hihara, J|Inoue, H|Yoshida, K|Yamashita, Y|Toge, T|Tsubota, N
PMID: 12866574
Journal: Dis Esophagus. 2004;17(4):315-21.
Title: Expression of p21(Waf1/Cip1) predicts response and survival of esophageal cancer patients treated by chemoradiotherapy.
Author: Nakamura, T|Hayashi, K|Ota, M|Ide, H|Takasaki, K|Mitsuhashi, M
PMID: 15569370
Journal: Int J Mol Med. 2005 Apr;15(4):617-26.
Title: Amplification and functional characterization of MUC1 promoter and gene-virotherapy via a targeting adenoviral vector expressing hSSTR2 gene in MUC1-positive Panc-1 pancreatic cancer cells in vitro.
Author: Chen, Limo|Liu, Qiang|Qin, Renyi|Le, Huangying|Xia, Ruijuan|Li, Weihua|Kumar, Manoj
PMID: 15754023
Journal: Genes Chromosomes Cancer. 2005 Dec;44(4):423-8.
Title: beta-Catenin splice variants and downstream targets as markers for neoplastic progression of esophageal cancer.
Author: Roth, Mark J|Hu, Nan|Johnson, Laura Lee|Quon-Hang, Wang|Ahnen, Dennis J|Iwamoto, Michiko|Dawsey, Sanford M|Taylor, Philip R|Huppi, Konrad
PMID: 16114033
Journal: Clin Cancer Res. 2005 Nov 1;11(21):7945-52.
Title: Histone deacetylase inhibitor FK228 activates tumor suppressor Prdx1 with apoptosis induction in esophageal cancer cells.
Author: Hoshino, Isamu|Matsubara, Hisahiro|Hanari, Naoyuki|Mori, Mikito|Nishimori, Takanori|Yoneyama, Yasuo|Akutsu, Yasunori|Sakata, Haruhito|Matsushita, Kazuyuki|Seki, Naohiko|Ochiai, Takenori
PMID: 16278420
Journal: Cancer Biol Ther. 2005 Nov;4(11):1216-21. Epub 2005 Nov 11.
Title: KLF4 and KLF5 regulate proliferation, apoptosis and invasion in esophageal cancer cells.
Author: Yang, Yizeng|Goldstein, Bree G|Chao, Hann-Hsiang|Katz, Jonathan P
PMID: 16357509
Journal: Int J Cancer. 2006 Apr 1;118(7):1814-22.
Title: Targeting the epidermal growth factor receptor by erlotinib (Tarceva) for the treatment of esophageal cancer.
Author: Sutter, Andreas P|Hopfner, Michael|Huether, Alexander|Maaser, Kerstin|Scherubl, Hans
PMID: 16217753
Journal: Exp Oncol. 2006 Sep;28(3):235-40.
Title: Relationship between HPV16/18 E6 and 53, 21WAF1, MDM2, Ki67 and cyclin D1 expression in esophageal squamous cell carcinoma: comparative study by using tissue microarray technology.
Author: Qi, Z L|Huo, X|Xu, X J|Zhang, B|Du, M G|Yang, H W|Zheng, L K|Li, J|Shen, Z Y
PMID: 17080019
Journal: Exp Biol Med (Maywood). 2006 Jan;231(1):84-90.
Title: ECRG1, a novel candidate of tumor suppressor gene in the esophageal carcinoma, triggers a senescent program in NIH3T3 cells.
Author: Zhao, Nianxi|Huang, Ge|Guo, Liping|Lu, Shih-Hsin
PMID: 16380648
Journal: Int J Cancer. 2006 Aug 1;119(3):508-14.
Title: Id-1 promotes proliferation of p53-deficient esophageal cancer cells.
Author: Hui, Cheuk Man|Cheung, Pak Yan|Ling, Ming Tat|Tsao, Sai Wah|Wang, Xianghong|Wong, Yong Chuan|Cheung, Annie L M
PMID: 16506209
Journal: Cancer Res. 2007 Mar 15;67(6):2535-43.
Title: Involvement of IFN regulatory factor (IRF)-1 and IRF-2 in the formation and progression of human esophageal cancers.
Author: Wang, Yan|Liu, Dong-Ping|Chen, Ping-Ping|Koeffler, H Phillip|Tong, Xiang-Jun|Xie, Dong
PMID: 17363571
Journal: Cell Calcium. 2008 Jan;43(1):49-58. Epub 2007 May 25.
Title: T-type Ca2+ channel expression in human esophageal carcinomas: a functional role in proliferation.
Author: Lu, Fengmin|Chen, Hairu|Zhou, Chun|Liu, Shuang|Guo, Mingzhou|Chen, Pingping|Zhuang, Hui|Xie, Dong|Wu, Songwei
PMID: 17532042
Journal: J Huazhong Univ Sci Technolog Med Sci. 2008 Jun;28(3):314-6.
Title: Effects of Oxymatrine on the apoptosis of human esophageal carcinoma Eca109 cell line and its mechanism.
Author: Jin, Yi|Hu, Jianli|Wang, Qiong|Li, Zhenyu|Chen, Yeshan
PMID: 18563331
Journal: Cancer Gene Ther. 2009 Nov;16(11):810-9.
Title: RNA interference-mediated knockdown of p21(WAF1) enhances anti-tumor cell activity of oncolytic adenoviruses.
Author: Shiina, M|Lacher, M D|Christian, C|Korn, W M
PMID: 19407849
Journal: Ann Surg Oncol. 2010 May;17(5):1453-8.
Title: p21 Waf1/Cip1 polymorphisms and risk of esophageal cancer.
Author: Yang, Wenjun|Qi, Qi|Zhang, Heng|Xu, Wenda|Chen, Zhiqiang|Wang, Li|Wang, Yin|Dong, Xiaowei|Jiao, Haiyan|Huo, Zhenghao
PMID: 20112071
Journal: Clin Cancer Res. 2011 Jan 1;17(1):46-55.
Title: Characterization of tumor-suppressive function of SOX6 in human esophageal squamous cell carcinoma.
Author: Qin, Yan-Ru|Tang, Hong|Xie, Fajun|Liu, Haibo|Zhu, Yinghui|Ai, Jiaoyu|Chen, Leilei|Li, Yan|Kwong, Dora L|Fu, Li|Guan, Xin-Yuan
PMID: 21084391
Journal: Cell Cycle. 2012 Nov 1;11(21):4033-9.
Title: p53 mutation alters the effect of the esophageal tumor suppressor KLF5 on keratinocyte proliferation.
Author: Yang, Yizeng|Tarapore, Rohinton S|Jarmel, Melissa H|Tetreault, Marie-Pier|Katz, Jonathan P
PMID: 22990386
Journal: Asian Pac J Cancer Prev. 2012;13(7):3233-8.
Title: MSP58 knockdown inhibits the proliferation of esophageal squamous cell carcinoma in vitro and in vivo.
Author: Xu, Chun-Sheng|Zheng, Jian-Yong|Zhang, Hai-Long|Zhao, Hua-Dong|Zhang, Jing|Wu, Guo-Qiang|Wu, Lin|Wang, Qing|Wang, Wei-Zhong|Zhang, Jian
PMID: 22994740
Journal: Pathol Res Pract. 2013 Jan 15;209(1):6-9.
Title: Correlation analysis of c-myc, p21(WAF/CIP1), p53, C-erbB-2 and COX-2 proteins in esophageal squamous cell carcinoma.
Author: Gomes, Thiago Simao|Noguti, Juliana|Forones, Nora Manoukian|Lima, Flavio Oliveira|Dobo, Cristine|Fernandes Junior, Joao Antao|Oshima, Celina Tizuko Fujiyama|Ribeiro, Daniel Araki
PMID: 23177619
Journal: Curr Cancer Drug Targets. 2013 Jul;13(6):611-24.
Title: Jaridonin, a novel ent-kaurene diterpenoid from Isodon rubescens, inducing apoptosis via production of reactive oxygen species in esophageal cancer cells.
Author: Ma, Yong-Cheng|Ke, Yu|Zi, Xiaolin|Zhao, Wen|Shi, Xiao-Jing|Liu, Hong-Min
PMID: 23597192
Journal: Cancer Sci. 2013 Nov;104(11):1544-51.
Title: Upregulation of Ying Yang 1 (YY1) suppresses esophageal squamous cell carcinoma development through heme oxygenase-1.
Author: Luo, Judong|Zhou, Xifa|Ge, Xin|Liu, Pengfei|Cao, Jianping|Lu, Xujing|Ling, Yang|Zhang, Shuyu
PMID: 23919806
Journal: Int J Biol Markers. 2014 Jun 25;29(2):e160-8.
Title: Association between SNPs in P53 binding regions and risk of esophageal squamous cell carcinoma.
Author: Wang, Kai|Liu, Botao|Li, Juan|Xiong, Gang|Guan, Xingying|Yang, Kang|Bai, Yun
PMID: 24474449
Journal: Oncotarget. 2014 Jul 30;5(14):5602-14.
Title: The tumor suppressive role of NUMB isoform 1 in esophageal squamous cell carcinoma.
Author: Hong, Junmou|Liu, Zhenguo|Zhu, Hua|Zhang, Xin|Liang, Yongju|Yao, Shiyuan|Wang, Fang|Xie, Xiaoyun|Zhang, Bo|Tan, Tao|Fu, Liwu|Nie, Jing|Cheng, Chao
PMID: 24980814
Journal: J Cell Biochem. 2014 Sep;115(9):1624-35.
Title: Obatoclax induces G1/G0-phase arrest via p38/p21(waf1/Cip1) signaling pathway in human esophageal cancer cells.
Author: Zhong, Desheng|Gu, Chunping|Shi, Lili|Xun, Tianrong|Li, Xiaojuan|Liu, Shuwen|Yu, Le
PMID: 24788582
Journal: Cancer Res. 2014 Jan 15;74(2):575-85.
Title: Small molecule agonists of PPAR-gamma exert therapeutic effects in esophageal cancer.
Author: Sawayama, Hiroshi|Ishimoto, Takatsugu|Watanabe, Masayuki|Yoshida, Naoya|Sugihara, Hidetaka|Kurashige, Junji|Hirashima, Kotaro|Iwatsuki, Masaaki|Baba, Yoshifumi|Oki, Eiji|Morita, Masaru|Shiose, Yoshinobu|Baba, Hideo
PMID: 24272485
Journal: Drug Des Devel Ther. 2015 Feb 17;9:993-1026.
Title: Bardoxolone methyl induces apoptosis and autophagy and inhibits epithelial-to-mesenchymal transition and stemness in esophageal squamous cancer cells.
Author: Wang, Yan-Yang|Yang, Yin-Xue|Zhao, Ren|Pan, Shu-Ting|Zhe, Hong|He, Zhi-Xu|Duan, Wei|Zhang, Xueji|Yang, Tianxin|Qiu, Jia-Xuan|Zhou, Shu-Feng
PMID: 25733817
Journal: Cell Death Dis. 2015 Oct 15;6:e1912.
Title: HOI-02 induces apoptosis and G2-M arrest in esophageal cancer mediated by ROS.
Author: Zhang, C|Liu, K|Yao, K|Reddy, K|Zhang, Y|Fu, Y|Yang, G|Zykova, T A|Shin, S H|Li, H|Ryu, J|Jiang, Y-N|Yin, X|Ma, W|Bode, A M|Dong, Z|Dong, Z
PMID: 26469961
Journal: Oncol Rep. 2016 Jun;35(6):3532-40.
Title: Miz-1 promotes the proliferation of esophageal cancer cells via suppression of p21 and release of p21-arrested cyclin D1.
Author: Luo, Jun|Zhang, Cheng|Wang, Congyi|Li, Linjun|Li, Chunhong|Li, Qiang|Zhang, Min|Wu, Qingchen
PMID: 27109891
Journal: Sci Rep. 2016 May 27;6:26821.
Title: RhBMP-2 Activates Hippo Signaling through RASSF1 in Esophageal Cancer Cells.
Author: Kim, Soo Mi|Ye, Shuai|Rah, So-Young|Park, Byung Hyun|Wang, Hongen|Kim, Jung-Ryul|Kim, Seung Ho|Jang, Kyu Yun|Lee, Kwang-Bok
PMID: 27230238
Journal: Aging (Albany NY). 2016 Jun;8(6):1236-49.
Title: Overexpressed HDAC4 is associated with poor survival and promotes tumor progression in esophageal carcinoma.
Author: Zeng, Li-Si|Yang, Xian-Zi|Wen, Yue-Feng|Mail, Shi-Juan|Wang, Meng-He|Zhang, Mei-Yin|Zheng, X F Steven|Wang, Hui-Yun
PMID: 27295551
Journal: Oncotarget. 2016 Dec 27;7(52):86211-86224.
Title: Induction of the mitochondria-mediated apoptosis in human esophageal cancer cells by DS2, a newly synthetic diterpenoid analog, is regulated by Bax and caused by generation of reactive oxygen species.
Author: Ma, Yong-Cheng|Ke, Yu|Zi, Xiaolin|Zhao, Fei|Yuan, Lin|Zhu, Ying-Li|Fan, Xia-Xia|Zhao, Ning-Min|Li, Qiao-Yan|Qin, Yu-Hua|Liu, Hong-Min
PMID: 27863415
Journal: Middle East J Dig Dis. 2016 Oct;8(4):297-302.
Title: Hesa-A Effects on Cell Cycle Signaling in Esophageal Carcinoma Cell Line.
Author: Ahmadian, Nasser|Pashaei-Asl, Roghiyeh|Samadi, Nasser|Rahmati-Yamchi, Mohammad|Rashidi, Mohammad-Reza|Ahmadian, Masomeh|Esmaeili, Moosa|Salamat, Faezeh|Besharat, Sima|Joshaghani, Hamid Reza
PMID: 27957293
Journal: Mol Cell Biochem. 2017 Jul;431(1-2):75-85.
Title: Comprehensive characterization of genes associated with the TP53 signal transduction pathway in various tumors.
Author: Ohnami, Shumpei|Ohshima, Keiichi|Nagashima, Takeshi|Urakami, Kenichi|Shimoda, Yuji|Saito, Junko|Naruoka, Akane|Hatakeyama, Keiichi|Mochizuki, Tohru|Serizawa, Masakuni|Ohnami, Sumiko|Kusuhara, Masatoshi|Yamaguchi, Ken
PMID: 28258440
Journal: Biomed Pharmacother. 2017 Jun;90:517-523.
Title: miRNA-200c enhances radiosensitivity of esophageal cancer by cell cycle arrest and targeting P21.
Author: Zheng, Ruzhen|Liu, Yuehua|Zhang, Xiaoling|Zhao, Pengjun|Deng, Qinghua
PMID: 28402920
Journal: Acta Pharmacol Sin. 2017 Dec;38(12):1632-1641.
Title: ABT-263 induces G1/G0-phase arrest, apoptosis and autophagy in human esophageal cancer cells in vitro.
Author: Lin, Qing-Huan|Que, Fu-Chang|Gu, Chun-Ping|Zhong, De-Sheng|Zhou, Dan|Kong, Yi|Yu, Le|Liu, Shu-Wen
PMID: 28713162
Journal: Oncol Lett. 2018 Apr;15(4):5071-5080.
Title: Upregulated long non-coding RNA SBF2-AS1 promotes proliferation in esophageal squamous cell carcinoma.
Author: Chen, Rui|Xia, Wenjia|Wang, Xiaoxiao|Qiu, Mantang|Yin, Rong|Wang, Siwei|Xi, Xiaoxiang|Wang, Jie|Xu, Youtao|Dong, Gaochao|Xu, Lin|De, Wei
PMID: 29552140