Primary Site >> Colorectal Cancer
Gene >> CDK9
| 1. | |||||||||||
| Journal: | Mol Pharmacol. 2003 Nov;64(5):1101-8. | ||||||||||
| Title: | Acquired cellular resistance to flavopiridol in a human colon carcinoma cell line involves up-regulation of the telomerase catalytic subunit and telomere elongation. Sensitivity of resistant cells to combination treatment with a telomerase inhibitor. | ||||||||||
| Author: | Incles, Christopher M|Schultes, Christoph M|Kelland, Lloyd R|Neidle, Stephen | ||||||||||
| PMID: | 14573759 | ||||||||||
| 2. | |||||||||||
| Journal: | Cancer Res. 2004 Jan 1;64(1):262-72. | ||||||||||
| Title: | The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway. | ||||||||||
| Author: | Whittaker, Steven R|Walton, Mike I|Garrett, Michelle D|Workman, Paul | ||||||||||
| PMID: | 14729633 | ||||||||||
| 3. | |||||||||||
| Journal: | Cancer Res. 2007 Sep 1;67(17):8325-34. | ||||||||||
| Title: | Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases. | ||||||||||
| Author: | Bettayeb, Karima|Tirado, Oscar M|Marionneau-Lambot, Severine|Ferandin, Yoan|Lozach, Olivier|Morris, Jonathan C|Mateo-Lozano, Silvia|Drueckes, Peter|Schachtele, Christoph|Kubbutat, Michael H G|Liger, Francois|Marquet, Bernard|Joseph, Benoit|Echalier, Aude| | ||||||||||
| PMID: | 17804748 | ||||||||||
| 4. | |||||||||||
| Journal: | Cancer Res. 2008 Apr 1;68(7):2312-20. | ||||||||||
| Title: | The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner. | ||||||||||
| Author: | Ambrosini, Grazia|Seelman, Sharon L|Qin, Li-Xuan|Schwartz, Gary K | ||||||||||
| PMID: | 18381438 | ||||||||||
| 5. | |||||||||||
| Journal: | Cancer Prev Res (Phila). 2009 Sep;2(9):800-6. | ||||||||||
| Title: | Chemoprevention of mouse intestinal tumorigenesis by the cyclin-dependent kinase inhibitor SNS-032. | ||||||||||
| Author: | Boquoi, Amelie|Chen, Tina|Enders, Greg H | ||||||||||
| PMID: | 19723896 | ||||||||||
| 6. | |||||||||||
| Journal: | Bioorg Med Chem. 2011 Nov 15;19(22):6949-65. | ||||||||||
| Title: | Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors. | ||||||||||
| Author: | Wilson, Stuart C|Atrash, Butrus|Barlow, Clare|Eccles, Susan|Fischer, Peter M|Hayes, Angela|Kelland, Lloyd|Jackson, Wayne|Jarman, Michael|Mirza, Amin|Moreno, Javier|Nutley, Bernard P|Raynaud, Florence I|Sheldrake, Peter|Walton, Mike|Westwood, Robert|Whitta | ||||||||||
| PMID: | 21982796 | ||||||||||
| 7. | |||||||||||
| Journal: | Eur J Med Chem. 2012 Nov;57:311-22. | ||||||||||
| Title: | Synthesis and biological evaluation of imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents. | ||||||||||
| Author: | Lukasik, Pawel M|Elabar, Sherifa|Lam, Frankie|Shao, Hao|Liu, Xiangrui|Abbas, Abdullah Y|Wang, Shudong | ||||||||||
| PMID: | 23085105 | ||||||||||
| 8. | |||||||||||
| Journal: | J Biol Regul Homeost Agents. 2015 Oct-Dec;29(4):823-8. | ||||||||||
| Title: | The profile of melatonin receptors gene expression and genes associated with their activity in colorectal cancer: a preliminary report. | ||||||||||
| Author: | Ziolko, E|Kokot, T|Skubis, A|Sikora, B|Szota-Czyz, J|Kruszniewska-Rajs, C|Wierzgon, J|Mazurek, U|Grochowska-Niedworok, E|Muc-Wierzgon, M | ||||||||||
| PMID: | 26753642 | ||||||||||
| 9. | |||||||||||
| Journal: | Drug Resist Updat. 2017 Nov;33-35:36-42. | ||||||||||
| Title: | TAK-ing aim at chemoresistance: The emerging role of MAP3K7 as a target for cancer therapy. | ||||||||||
| Author: | Santoro, Raffaela|Carbone, Carmine|Piro, Geny|Chiao, Paul J|Melisi, Davide | ||||||||||
| PMID: | 29145973 | ||||||||||
| 10. | |||||||||||
| Journal: | Mol Oncol. 2018 Mar;12(3):287-304. | ||||||||||
| Title: | Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor. | ||||||||||
| Author: | Whittaker, Steven R|Barlow, Clare|Martin, Mathew P|Mancusi, Caterina|Wagner, Steve|Self, Annette|Barrie, Elaine|Te Poele, Robert|Sharp, Swee|Brown, Nathan|Wilson, Stuart|Jackson, Wayne|Fischer, Peter M|Clarke, Paul A|Walton, Michael I|McDonald, Edward|Bla | ||||||||||
| PMID: | 29063678 | ||||||||||
| 11. | |||||||||||
| Journal: | Mol Cell Biol. 2018 May 15;38(11). pii: MCB.00573-17. | ||||||||||
| Title: | Depletion of Mediator Kinase Module Subunits Represses Superenhancer-Associated Genes in Colon Cancer Cells. | ||||||||||
| Author: | Kuuluvainen, Emilia|Domenech-Moreno, Eva|Niemela, Elina H|Makela, Tomi P | ||||||||||
| PMID: | 29507187 | ||||||||||
| 12. | |||||||||||
| Journal: | Mol Cancer Ther. 2018 Jun;17(6):1156-1166. | ||||||||||
| Title: | ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment. | ||||||||||
| Author: | Patel, Hetal|Periyasamy, Manikandan|Sava, Georgina P|Bondke, Alexander|Slafer, Brian W|Kroll, Sebastian H B|Barbazanges, Marion|Starkey, Richard|Ottaviani, Silvia|Harrod, Alison|Aboagye, Eric O|Buluwela, Laki|Fuchter, Matthew J|Barrett, Anthony G M|Coombe | ||||||||||
| PMID: | 29545334 | ||||||||||
| 13. | |||||||||||
| Journal: | Eur J Med Chem. 2018 Sep 13;158:896-916. | ||||||||||
| Title: | Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4- yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor. | ||||||||||
| Author: | Wang, Beilei|Wu, Jiaxin|Wu, Yun|Chen, Cheng|Zou, Fengming|Wang, Aoli|Wu, Hong|Hu, Zhenquan|Jiang, Zongru|Liu, Qingwang|Wang, Wei|Zhang, Yicong|Liu, Feiyang|Zhao, Ming|Hu, Jie|Huang, Tao|Ge, Juan|Wang, Li|Ren, Tao|Wang, Yuxin|Liu, Jing|Liu, Qingsong | ||||||||||
| PMID: | 30253346 | ||||||||||