Primary Site >> Colorectal Cancer

Gene >> CDK9

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Ref: Acquired cellular resistance to flavopiridol in a human colon carcinoma cell line involves up-regulation of the telomerase catalytic subunit and telomere elongation. Sensitivity of resistant cells to combination treatment with a telomerase inhibitor.
PMID: 14573759
 Ref: The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway.
PMID: 14729633
 Ref: Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases.
PMID: 17804748
 Ref: The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner.
PMID: 18381438
 Ref: Chemoprevention of mouse intestinal tumorigenesis by the cyclin-dependent kinase inhibitor SNS-032.
PMID: 19723896
 Ref: Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors.
PMID: 21982796
 Ref: Synthesis and biological evaluation of imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents.
PMID: 23085105
 Ref: The profile of melatonin receptors gene expression and genes associated with their activity in colorectal cancer: a preliminary report.
PMID: 26753642
 Ref: TAK-ing aim at chemoresistance: The emerging role of MAP3K7 as a target for cancer therapy.
PMID: 29145973
 Ref: Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor.
PMID: 29063678
Ref: Depletion of Mediator Kinase Module Subunits Represses Superenhancer-Associated Genes in Colon Cancer Cells.
PMID: 29507187
Ref: ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment.
PMID: 29545334
Ref: Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4- yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor.
PMID: 30253346