Primary Site >> Colorectal Cancer
Gene >> CDK8
| 1. | |||||||||||
| Journal: | Nature. 2008 Sep 25;455(7212):547-51. | ||||||||||
| Title: | CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. | ||||||||||
| Author: | Firestein, Ron|Bass, Adam J|Kim, So Young|Dunn, Ian F|Silver, Serena J|Guney, Isil|Freed, Ellen|Ligon, Azra H|Vena, Natalie|Ogino, Shuji|Chheda, Milan G|Tamayo, Pablo|Finn, Stephen|Shrestha, Yashaswi|Boehm, Jesse S|Jain, Supriya|Bojarski, Emeric|Mermel, C | ||||||||||
| PMID: | 18794900 | ||||||||||
| 2. | |||||||||||
| Journal: | Cancer Res. 2009 Oct 15;69(20):7899-901. | ||||||||||
| Title: | Revving the Throttle on an oncogene: CDK8 takes the driver seat. | ||||||||||
| Author: | Firestein, Ron|Hahn, William C | ||||||||||
| PMID: | 19808961 | ||||||||||
| 3. | |||||||||||
| Journal: | Int J Cancer. 2010 Jun 15;126(12):2863-73. | ||||||||||
| Title: | CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival. | ||||||||||
| Author: | Firestein, Ron|Shima, Kaori|Nosho, Katsuhiko|Irahara, Natsumi|Baba, Yoshifumi|Bojarski, Emeric|Giovannucci, Edward L|Hahn, William C|Fuchs, Charles S|Ogino, Shuji | ||||||||||
| PMID: | 19790197 | ||||||||||
| 4. | |||||||||||
| Journal: | Neoplasia. 2010 May;12(5):415-24. | ||||||||||
| Title: | Silibinin suppresses growth of human colorectal carcinoma SW480 cells in culture and xenograft through down-regulation of beta-catenin-dependent signaling. | ||||||||||
| Author: | Kaur, Manjinder|Velmurugan, Balaiya|Tyagi, Alpna|Agarwal, Chapla|Singh, Rana P|Agarwal, Rajesh | ||||||||||
| PMID: | 20454513 | ||||||||||
| 5. | |||||||||||
| Journal: | Oncol Rep. 2010 Jul;24(1):285-91. | ||||||||||
| Title: | Role of CDK8 and beta-catenin in colorectal adenocarcinoma. | ||||||||||
| Author: | Seo, Jong-Og|Han, Song Iy|Lim, Sung-Chul | ||||||||||
| PMID: | 20514474 | ||||||||||
| 6. | |||||||||||
| Journal: | Nature. 2010 Dec 23;468(7327):1105-9. | ||||||||||
| Title: | The histone variant macroH2A suppresses melanoma progression through regulation of CDK8. | ||||||||||
| Author: | Kapoor, Avnish|Goldberg, Matthew S|Cumberland, Lara K|Ratnakumar, Kajan|Segura, Miguel F|Emanuel, Patrick O|Menendez, Silvia|Vardabasso, Chiara|Leroy, Gary|Vidal, Claudia I|Polsky, David|Osman, Iman|Garcia, Benjamin A|Hernando, Eva|Bernstein, Emily | ||||||||||
| PMID: | 21179167 | ||||||||||
| 7. | |||||||||||
| Journal: | BMC Syst Biol. 2011 Feb 26;5:35. | ||||||||||
| Title: | A Boolean-based systems biology approach to predict novel genes associated with cancer: Application to colorectal cancer. | ||||||||||
| Author: | Nagaraj, Shivashankar H|Reverter, Antonio | ||||||||||
| PMID: | 21352556 | ||||||||||
| 8. | |||||||||||
| Journal: | J Genet Genomics. 2011 Oct 20;38(10):439-52. | ||||||||||
| Title: | Dysregulation of CDK8 and Cyclin C in tumorigenesis. | ||||||||||
| Author: | Xu, Wu|Ji, Jun-Yuan | ||||||||||
| PMID: | 22035865 | ||||||||||
| 9. | |||||||||||
| Journal: | J Exp Clin Cancer Res. 2011 Nov 22;30:109. | ||||||||||
| Title: | Effects of cyclin-dependent kinase 8 specific siRNA on the proliferation and apoptosis of colon cancer cells. | ||||||||||
| Author: | He, Song-Bing|Yuan, Yin|Wang, Lei|Yu, Min-Jing|Zhu, Yi-Bei|Zhu, Xing-Guo | ||||||||||
| PMID: | 22104393 | ||||||||||
| 10. | |||||||||||
| Journal: | Cancer Res. 2012 Apr 15;72(8):2129-39. | ||||||||||
| Title: | CDK8 maintains tumor dedifferentiation and embryonic stem cell pluripotency. | ||||||||||
| Author: | Adler, Adam S|McCleland, Mark L|Truong, Tom|Lau, Shari|Modrusan, Zora|Soukup, Tim M|Roose-Girma, Merone|Blackwood, Elizabeth M|Firestein, Ron | ||||||||||
| PMID: | 22345154 | ||||||||||
| 11. | |||||||||||
| Journal: | J Virol. 2012 May;86(10):5742-51. | ||||||||||
| Title: | Retroviral cyclin enhances cyclin-dependent kinase-8 activity. | ||||||||||
| Author: | Rovnak, Joel|Brewster, Connie D|Quackenbush, Sandra L | ||||||||||
| PMID: | 22379099 | ||||||||||
| 12. | |||||||||||
| Journal: | Cell Cycle. 2013 Mar 15;12(6):987-99. | ||||||||||
| Title: | Tumor-suppressive effects of CDK8 in endometrial cancer cells. | ||||||||||
| Author: | Gu, Weiting|Wang, Chenguang|Li, Weihua|Hsu, Fu-Ning|Tian, Lifeng|Zhou, Jie|Yuan, Cunzhong|Xie, Xiao-Jun|Jiang, Tao|Addya, Sankar|Tai, Yanhong|Kong, Beihua|Ji, Jun-Yuan | ||||||||||
| PMID: | 23454913 | ||||||||||
| 13. | |||||||||||
| Journal: | Toxicology. 2013 Oct 4;312:36-47. | ||||||||||
| Title: | Wogonin induced G1 cell cycle arrest by regulating Wnt/beta-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells. | ||||||||||
| Author: | He, Licheng|Lu, Na|Dai, Qinsheng|Zhao, Yue|Zhao, Li|Wang, Hu|Li, Zhiyu|You, Qidong|Guo, Qinglong | ||||||||||
| PMID: | 23907061 | ||||||||||
| 14. | |||||||||||
| Journal: | Hum Mutat. 2014 Sep;35(9):1136-41. | ||||||||||
| Title: | Mutations in Exon 1 highlight the role of MED12 in uterine leiomyomas. | ||||||||||
| Author: | Kampjarvi, Kati|Park, Min Ju|Mehine, Miika|Kim, Nam Hee|Clark, Alison D|Butzow, Ralf|Bohling, Tom|Bohm, Jan|Mecklin, Jukka-Pekka|Jarvinen, Heikki|Tomlinson, Ian P M|van der Spuy, Zephne M|Sjoberg, Jari|Boyer, Thomas G|Vahteristo, Pia | ||||||||||
| PMID: | 24980722 | ||||||||||
| 15. | |||||||||||
| Journal: | Cancer Lett. 2015 Jan 28;356(2 Pt B):613-27. | ||||||||||
| Title: | Mutated K-ras activates CDK8 to stimulate the epithelial-to-mesenchymal transition in pancreatic cancer in part via the Wnt/beta-catenin signaling pathway. | ||||||||||
| Author: | Xu, Wei|Wang, Ziwei|Zhang, Wei|Qian, Kun|Li, Hui|Kong, Dequan|Li, Yuqiang|Tang, Yucheng | ||||||||||
| PMID: | 25305448 | ||||||||||
| 16. | |||||||||||
| Journal: | J Virol. 2015 May;89(10):5450-61. | ||||||||||
| Title: | Retroviral cyclin controls cyclin-dependent kinase 8-mediated transcription elongation and reinitiation. | ||||||||||
| Author: | Birkenheuer, Claire H|Brewster, Connie D|Quackenbush, Sandra L|Rovnak, Joel | ||||||||||
| PMID: | 25741012 | ||||||||||
| 17. | |||||||||||
| Journal: | J Pathol. 2015 Dec;237(4):508-19. | ||||||||||
| Title: | Cdk8 deletion in the Apc(Min) murine tumour model represses EZH2 activity and accelerates tumourigenesis. | ||||||||||
| Author: | McCleland, Mark L|Soukup, Tim M|Liu, Scot D|Esensten, Jonathan H|de Sousa e Melo, Felipe|Yaylaoglu, Murat|Warming, Soren|Roose-Girma, Merone|Firestein, Ron | ||||||||||
| PMID: | 26235356 | ||||||||||
| 18. | |||||||||||
| Journal: | Biomed Pharmacother. 2015 Aug;74:153-7. | ||||||||||
| Title: | Downregulation of CDK-8 inhibits colon cancer hepatic metastasis by regulating Wnt/beta-catenin pathway. | ||||||||||
| Author: | Cai, Wen-Song|Shen, Fei|Feng, Zhe|Chen, Ji-Wei|Liu, Qi-Cai|Li, Er-Mao|Xu, Bo|Cao, Jie | ||||||||||
| PMID: | 26349978 | ||||||||||
| 19. | |||||||||||
| Journal: | J Med Chem. 2016 Feb 11;59(3):1078-101. | ||||||||||
| Title: | Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19. | ||||||||||
| Author: | Mallinger, Aurelie|Schiemann, Kai|Rink, Christian|Stieber, Frank|Calderini, Michel|Crumpler, Simon|Stubbs, Mark|Adeniji-Popoola, Olajumoke|Poeschke, Oliver|Busch, Michael|Czodrowski, Paul|Musil, Djordje|Schwarz, Daniel|Ortiz-Ruiz, Maria-Jesus|Schneider, R | ||||||||||
| PMID: | 26796641 | ||||||||||
| 20. | |||||||||||
| Journal: | EBioMedicine. 2016 Nov;13:113-124. | ||||||||||
| Title: | H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-beta-Catenin Signaling in Colorectal Cancer. | ||||||||||
| Author: | Ohtsuka, Masahisa|Ling, Hui|Ivan, Cristina|Pichler, Martin|Matsushita, Daisuke|Goblirsch, Matthew|Stiegelbauer, Verena|Shigeyasu, Kunitoshi|Zhang, Xinna|Chen, Meng|Vidhu, Fnu|Bartholomeusz, Geoffrey A|Toiyama, Yuji|Kusunoki, Masato|Doki, Yuichiro|Mori, Ma | ||||||||||
| PMID: | 27789274 | ||||||||||
| 21. | |||||||||||
| Journal: | J Med Chem. 2016 Oct 27;59(20):9337-9349. | ||||||||||
| Title: | Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening. | ||||||||||
| Author: | Czodrowski, Paul|Mallinger, Aurelie|Wienke, Dirk|Esdar, Christina|Poschke, Oliver|Busch, Michael|Rohdich, Felix|Eccles, Suzanne A|Ortiz-Ruiz, Maria-Jesus|Schneider, Richard|Raynaud, Florence I|Clarke, Paul A|Musil, Djordje|Schwarz, Daniel|Dale, Trevor|Urb | ||||||||||
| PMID: | 27490956 | ||||||||||
| 22. | |||||||||||
| Journal: | Am J Transl Res. 2016 May 15;8(5):2088-96. eCollection 2016. | ||||||||||
| Title: | Tumor-suppressive microRNA-195-5p regulates cell growth and inhibits cell cycle by targeting cyclin dependent kinase 8 in colon cancer. | ||||||||||
| Author: | Luo, Qifeng|Zhang, Zhenyu|Dai, Zhenling|Basnet, Shiva|Li, Shuping|Xu, Bin|Ge, Haiyan | ||||||||||
| PMID: | 27347317 | ||||||||||
| 23. | |||||||||||
| Journal: | ACS Med Chem Lett. 2016 Mar 28;7(6):573-8. | ||||||||||
| Title: | 2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19. | ||||||||||
| Author: | Mallinger, Aurelie|Schiemann, Kai|Rink, Christian|Sejberg, Jimmy|Honey, Mark A|Czodrowski, Paul|Stubbs, Mark|Poeschke, Oliver|Busch, Michael|Schneider, Richard|Schwarz, Daniel|Musil, Djordje|Burke, Rosemary|Urbahns, Klaus|Workman, Paul|Wienke, Dirk|Clarke | ||||||||||
| PMID: | 27326329 | ||||||||||
| 24. | |||||||||||
| Journal: | Cell Rep. 2016 Jun 28;16(1):37-47. | ||||||||||
| Title: | The TIP60 Complex Is a Conserved Coactivator of HIF1A. | ||||||||||
| Author: | Perez-Perri, Joel I|Dengler, Veronica L|Audetat, K Audrey|Pandey, Ahwan|Bonner, Elizabeth A|Urh, Marjeta|Mendez, Jacqui|Daniels, Danette L|Wappner, Pablo|Galbraith, Matthew D|Espinosa, Joaquin M | ||||||||||
| PMID: | 27320910 | ||||||||||
| 25. | |||||||||||
| Journal: | ACS Med Chem Lett. 2016 Jan 6;7(3):223-8. | ||||||||||
| Title: | Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells. | ||||||||||
| Author: | Koehler, Michael F T|Bergeron, Philippe|Blackwood, Elizabeth M|Bowman, Krista|Clark, Kevin R|Firestein, Ron|Kiefer, James R|Maskos, Klaus|McCleland, Mark L|Orren, Linda|Salphati, Laurent|Schmidt, Steve|Schneider, Elisabeth V|Wu, Jiansheng|Beresini, Mauree | ||||||||||
| PMID: | 26985305 | ||||||||||
| 26. | |||||||||||
| Journal: | Bioorg Med Chem Lett. 2016 Mar 1;26(5):1443-51. | ||||||||||
| Title: | Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore. | ||||||||||
| Author: | Schiemann, Kai|Mallinger, Aurelie|Wienke, Dirk|Esdar, Christina|Poeschke, Oliver|Busch, Michael|Rohdich, Felix|Eccles, Suzanne A|Schneider, Richard|Raynaud, Florence I|Czodrowski, Paul|Musil, Djordje|Schwarz, Daniel|Urbahns, Klaus|Blagg, Julian | ||||||||||
| PMID: | 26852363 | ||||||||||
| 27. | |||||||||||
| Journal: | J Chem Inf Model. 2017 Mar 27;57(3):413-416. | ||||||||||
| Title: | In Search of Novel CDK8 Inhibitors by Virtual Screening. | ||||||||||
| Author: | Kumarasiri, Malika|Teo, Theodosia|Yu, Mingfeng|Philip, Stephen|Basnet, Sunita K C|Albrecht, Hugo|Sykes, Matthew J|Wang, Peng|Wang, Shudong | ||||||||||
| PMID: | 28191946 | ||||||||||
| 28. | |||||||||||
| Journal: | Chem Cent J. 2017 Sep 18;11(1):89. | ||||||||||
| Title: | Synthesis, molecular docking and biological evaluation of bis-pyrimidine Schiff base derivatives. | ||||||||||
| Author: | Kumar, Sanjiv|Lim, Siong Meng|Ramasamy, Kalavathy|Vasudevan, Mani|Shah, Syed Adnan Ali|Selvaraj, Manikandan|Narasimhan, Balasubramanian | ||||||||||
| PMID: | 29086867 | ||||||||||
| 29. | |||||||||||
| Journal: | Cell Rep. 2017 Nov 7;21(6):1495-1506. | ||||||||||
| Title: | CDK8 Kinase Activity Promotes Glycolysis. | ||||||||||
| Author: | Galbraith, Matthew D|Andrysik, Zdenek|Pandey, Ahwan|Hoh, Maria|Bonner, Elizabeth A|Hill, Amanda A|Sullivan, Kelly D|Espinosa, Joaquin M | ||||||||||
| PMID: | 29117556 | ||||||||||
| 30. | |||||||||||
| Journal: | Oncotarget. 2017 Dec 15;9(3):3394-3405. | ||||||||||
| Title: | Copy number profiles of paired primary and metastatic colorectal cancers. | ||||||||||
| Author: | Kawamata, Futoshi|Patch, Ann-Marie|Nones, Katia|Bond, Catherine|McKeone, Diane|Pearson, Sally-Ann|Homma, Shigenori|Liu, Cheng|Fennell, Lochlan|Dumenil, Troy|Hartel, Gunter|Kobayasi, Nozomi|Yokoo, Hideki|Fukai, Moto|Nishihara, Hiroshi|Kamiyama, Toshiya|Bur | ||||||||||
| PMID: | 29423054 | ||||||||||
| 31. | |||||||||||
| Journal: | J Biol Chem. 2018 Mar 30;293(13):4870-4882. | ||||||||||
| Title: | Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19. | ||||||||||
| Author: | Park, Min Ju|Shen, Hailian|Spaeth, Jason M|Tolvanen, Jaana H|Failor, Courtney|Knudtson, Jennifer F|McLaughlin, Jessica|Halder, Sunil K|Yang, Qiwei|Bulun, Serdar E|Al-Hendy, Ayman|Schenken, Robert S|Aaltonen, Lauri A|Boyer, Thomas G | ||||||||||
| PMID: | 29440396 | ||||||||||
| 32. | |||||||||||
| Journal: | Mol Cell Biol. 2018 May 15;38(11). pii: MCB.00573-17. | ||||||||||
| Title: | Depletion of Mediator Kinase Module Subunits Represses Superenhancer-Associated Genes in Colon Cancer Cells. | ||||||||||
| Author: | Kuuluvainen, Emilia|Domenech-Moreno, Eva|Niemela, Elina H|Makela, Tomi P | ||||||||||
| PMID: | 29507187 | ||||||||||
| 33. | |||||||||||
| Journal: | J Comput Aided Mol Des. 2018 Jun;32(6):671-685. | ||||||||||
| Title: | A molecular dynamics investigation of CDK8/CycC and ligand binding: conformational flexibility and implication in drug discovery. | ||||||||||
| Author: | Cholko, Timothy|Chen, Wei|Tang, Zhiye|Chang, Chia-En A | ||||||||||
| PMID: | 29737445 | ||||||||||
| 34. | |||||||||||
| Journal: | Br J Cancer. 2018 Jul;119(2):230-240. | ||||||||||
| Title: | Integrative analysis of oncogenic fusion genes and their functional impact in colorectal cancer. | ||||||||||
| Author: | Choi, Yuri|Kwon, Chae Hwa|Lee, Seon Jin|Park, Joonghoon|Shin, Jong-Yeon|Park, Do Youn | ||||||||||
| PMID: | 29955133 | ||||||||||
| 35. | |||||||||||
| Journal: | Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6760-E6769. | ||||||||||
| Title: | Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation. | ||||||||||
| Author: | Zhou, Jiuli|Zeng, Yongji|Cui, Lian|Chen, Xingcheng|Stauffer, Seth|Wang, Zhan|Yu, Fang|Lele, Subodh M|Talmon, Geoffrey A|Black, Adrian R|Chen, Yuanhong|Dong, Jixin | ||||||||||
| PMID: | 29967145 | ||||||||||
| 36. | |||||||||||
| Journal: | Cancer Res. 2018 Sep 5. pii: 0008-5472.CAN-18-1583. | ||||||||||
| Title: | CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix metalloproteinases. | ||||||||||
| Author: | Liang, Jiaxin|Chen, Mengqian|Hughes, Daniel|Chumanevich, Alexander A|Altilia, Serena|Kaza, Vimala|Lim, Chang-Uk|Kiaris, Hippokratis|Mythreye, Karthikeyan|Pena, Maria Marjorette|Broude, Eugenia V|Roninson, Igor B | ||||||||||
| PMID: | 30185549 | ||||||||||