Primary Site >> Colorectal Cancer
Gene >> CDK8
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. PMID: 18794900 |
Ref: Revving the Throttle on an oncogene: CDK8 takes the driver seat. PMID: 19808961 |
Ref: CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival. PMID: 19790197 Ref: Silibinin suppresses growth of human colorectal carcinoma SW480 cells in culture and xenograft through down-regulation of beta-catenin-dependent signaling. PMID: 20454513 Ref: Role of CDK8 and beta-catenin in colorectal adenocarcinoma. PMID: 20514474 Ref: The histone variant macroH2A suppresses melanoma progression through regulation of CDK8. PMID: 21179167 |
Ref: A Boolean-based systems biology approach to predict novel genes associated with cancer: Application to colorectal cancer. PMID: 21352556 Ref: Dysregulation of CDK8 and Cyclin C in tumorigenesis. PMID: 22035865 Ref: Effects of cyclin-dependent kinase 8 specific siRNA on the proliferation and apoptosis of colon cancer cells. PMID: 22104393 |
Ref: CDK8 maintains tumor dedifferentiation and embryonic stem cell pluripotency. PMID: 22345154 Ref: Retroviral cyclin enhances cyclin-dependent kinase-8 activity. PMID: 22379099 |
Ref: Tumor-suppressive effects of CDK8 in endometrial cancer cells. PMID: 23454913 Ref: Wogonin induced G1 cell cycle arrest by regulating Wnt/beta-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells. PMID: 23907061 |
Ref: Mutations in Exon 1 highlight the role of MED12 in uterine leiomyomas. PMID: 24980722 |
Ref: Mutated K-ras activates CDK8 to stimulate the epithelial-to-mesenchymal transition in pancreatic cancer in part via the Wnt/beta-catenin signaling pathway. PMID: 25305448 Ref: Retroviral cyclin controls cyclin-dependent kinase 8-mediated transcription elongation and reinitiation. PMID: 25741012 Ref: Cdk8 deletion in the Apc(Min) murine tumour model represses EZH2 activity and accelerates tumourigenesis. PMID: 26235356 Ref: Downregulation of CDK-8 inhibits colon cancer hepatic metastasis by regulating Wnt/beta-catenin pathway. PMID: 26349978 |
Ref: Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19. PMID: 26796641 Ref: Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore. PMID: 26852363 Ref: Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells. PMID: 26985305 Ref: The TIP60 Complex Is a Conserved Coactivator of HIF1A. PMID: 27320910 Ref: 2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19. PMID: 27326329 Ref: Tumor-suppressive microRNA-195-5p regulates cell growth and inhibits cell cycle by targeting cyclin dependent kinase 8 in colon cancer. PMID: 27347317 Ref: Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening. PMID: 27490956 Ref: H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-beta-Catenin Signaling in Colorectal Cancer. PMID: 27789274 |
Ref: In Search of Novel CDK8 Inhibitors by Virtual Screening. PMID: 28191946 Ref: Synthesis, molecular docking and biological evaluation of bis-pyrimidine Schiff base derivatives. PMID: 29086867 Ref: CDK8 Kinase Activity Promotes Glycolysis. PMID: 29117556 |
Ref: Copy number profiles of paired primary and metastatic colorectal cancers. PMID: 29423054 Ref: Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19. PMID: 29440396 Ref: Depletion of Mediator Kinase Module Subunits Represses Superenhancer-Associated Genes in Colon Cancer Cells. PMID: 29507187 Ref: A molecular dynamics investigation of CDK8/CycC and ligand binding: conformational flexibility and implication in drug discovery. PMID: 29737445 Ref: Integrative analysis of oncogenic fusion genes and their functional impact in colorectal cancer. PMID: 29955133 Ref: Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation. PMID: 29967145 Ref: CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix metalloproteinases. PMID: 30185549 |