Primary Site >> Esophagus Cancer

Gene >> CDK4

Journal: Hum Mol Genet. 1995 Oct;4(10):1883-7.
Title: Intragenic mutations of CDKN2B and CDKN2A in primary human esophageal cancers.
Author: Suzuki, H|Zhou, X|Yin, J|Lei, J|Jiang, H Y|Suzuki, Y|Chan, T|Hannon, G J|Mergner, W J|Abraham, J M
PMID: 8595411
Journal: Oncogene. 1995 Feb 2;10(3):619-22.
Title: MTS-1 (CDKN2) tumor suppressor gene deletions are a frequent event in esophagus squamous cancer and pancreatic adenocarcinoma cell lines.
Author: Liu, Q|Yan, Y X|McClure, M|Nakagawa, H|Fujimura, F|Rustgi, A K
PMID: 7845688
Journal: Nihon Rinsho. 1996 Apr;54(4):965-71.
Title: [RB gene expression in gastrointestinal tract].
Author: Monden, T|Yamamoto, H|Ikeda, K|Izawa, H|Tsujie, M|Ohnishi, T|Miyoshi, Y|Sekimoto, M|Tomita, N|Monden, M
PMID: 8920658
Journal: Zhonghua Bing Li Xue Za Zhi. 1996 Dec;25(6):336-9.
Title: [The expression of Rb, p16 and cyclin D1 in 41 esophageal cancers].
Author: Zheng, J|Zhou, C|Xiao, F
PMID: 9388858
Journal: J Exp Ther Oncol. 1996 Jan;1(1):7-12.
Title: Expression of cyclin D1, CDK4 and p27KIP1 is associated with the p16MTS1 gene status in human esophageal carcinoma cell lines.
Author: Kitahara, K|Yasui, W|Yokozaki, H|Semba, S|Hamamoto, T|Hisatsugu, T|Tahara, E
PMID: 9414383
Journal: Carcinogenesis. 1997 Jun;18(6):1139-48.
Title: Increased expression of the P27KIP1 protein in human esophageal cancer cell lines that over-express cyclin D1.
Author: Doki, Y|Imoto, M|Han, E K|Sgambato, A|Weinstein, I B
PMID: 9214595
Journal: Int J Oncol. 1998 Sep;13(3):455-60.
Title: Effect of cyclin D1 and associated proteins on proliferation of esophageal squamous cell carcinoma.
Author: Shamma, A|Doki, Y|Shiozaki, H|Tsujinaka, T|Inoue, M|Yano, M|Kimura, Y|Yamamoto, M|Monden, M
PMID: 9683778
Journal: Carcinogenesis. 2000 Aug;21(8):1537-46.
Title: A potential mechanism for fumonisin B(1)-mediated hepatocarcinogenesis: cyclin D1 stabilization associated with activation of Akt and inhibition of GSK-3beta activity.
Author: Ramljak, D|Calvert, R J|Wiesenfeld, P W|Diwan, B A|Catipovic, B|Marasas, W F|Victor, T C|Anderson, L M|Gelderblom, W C
PMID: 10910956
Journal: Cancer Res. 2000 Aug 15;60(16):4589-95.
Title: Early deregulation of the the p16ink4a-cyclin D1/cyclin-dependent kinase 4-retinoblastoma pathway in cell proliferation-driven esophageal tumorigenesis in zinc-deficient rats.
Author: Fong, L Y|Nguyen, V T|Farber, J L|Huebner, K|Magee, P N
PMID: 10969811
Journal: Int J Oncol. 2001 Jan;18(1):151-5.
Title: Insufficient effect of p27(KIP1) to inhibit cyclin D1 in human esophageal cancer in vitro.
Author: Anayama, T|Furihata, M|Takeuchi, T|Sonobe, H|Sasaguri, S|Matsumoto, M|Ohtsuki, Y
PMID: 11115553
Journal: Exp Mol Pathol. 2002 Dec;73(3):198-208.
Title: MDM2 and CDK4 expression in carcinosarcoma of the esophagus: comparison with squamous cell carcinoma and review of the literature.
Author: Nikitakis, Nikolaos G|Drachenberg, Cinthia B|Papadimitriou, John C
PMID: 12565795
Journal: Cancer Res. 2003 Nov 1;63(21):7056-61.
Title: An alternatively spliced cyclin D1 isoform, cyclin D1b, is a nuclear oncogene.
Author: Lu, Fengmin|Gladden, Andrew B|Diehl, J Alan
PMID: 14612495
Journal: Zhonghua Zhong Liu Za Zhi. 2004 Oct;26(10):612-4.
Title: [Flow cytometric detection and significance of four cyclins in esophageal cancer].
Author: Du, Yun|Wang, Xiao-ling|Wu, Guo-xiang|Wang, Yong-jun|Yang, Hui-chai|Zuo, Lian-fu
PMID: 15634523
Journal: Int J Cancer. 2006 Aug 1;119(3):508-14.
Title: Id-1 promotes proliferation of p53-deficient esophageal cancer cells.
Author: Hui, Cheuk Man|Cheung, Pak Yan|Ling, Ming Tat|Tsao, Sai Wah|Wang, Xianghong|Wong, Yong Chuan|Cheung, Annie L M
PMID: 16506209
Journal: Oncogene. 2006 Oct 12;25(47):6291-303.
Title: Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1.
Author: Benzeno, S|Lu, F|Guo, M|Barbash, O|Zhang, F|Herman, J G|Klein, P S|Rustgi, A|Diehl, J A
PMID: 16732330
Journal: J Thorac Cardiovasc Surg. 2007 Mar;133(3):763-9.
Title: Cytogenetic characterization and gene expression profiling in the rat reflux-induced esophageal tumor model.
Author: Bonde, Pramod|Sui, Guoping|Dhara, Surajit|Wang, Jiaai|Broor, Apoorv|Kim, Irene F|Wiley, John E|Marti, Guy|Duncan, Mark|Jaffee, Elizabeth|Montgomery, Elizabeth|Maitra, Anirban|Harmon, John W
PMID: 17320581
Journal: Clin Cancer Res. 2011 Jan 1;17(1):46-55.
Title: Characterization of tumor-suppressive function of SOX6 in human esophageal squamous cell carcinoma.
Author: Qin, Yan-Ru|Tang, Hong|Xie, Fajun|Liu, Haibo|Zhu, Yinghui|Ai, Jiaoyu|Chen, Leilei|Li, Yan|Kwong, Dora L|Fu, Li|Guan, Xin-Yuan
PMID: 21084391
Journal: Oncol Lett. 2011 Nov;2(6):1203-1211. Epub 2011 Sep 2.
Title: Impaired nuclear export of tumor-derived c-terminal truncated cyclin D1 mutant in ESCC cancer.
Author: Hao, Meili|Chen, Xiangmei|Zhang, Ting|Shen, Tao|Xie, Qing|Xing, Xiujuan|Gu, Hongxi|Lu, Fengmin
PMID: 22848289
Journal: Asian Pac J Cancer Prev. 2012;13(7):3233-8.
Title: MSP58 knockdown inhibits the proliferation of esophageal squamous cell carcinoma in vitro and in vivo.
Author: Xu, Chun-Sheng|Zheng, Jian-Yong|Zhang, Hai-Long|Zhao, Hua-Dong|Zhang, Jing|Wu, Guo-Qiang|Wu, Lin|Wang, Qing|Wang, Wei-Zhong|Zhang, Jian
PMID: 22994740
Journal: Int J Oncol. 2013 Feb;42(2):517-24.
Title: Antitumor effect of metformin in esophageal cancer: in vitro study.
Author: Kobayashi, Mitsuyoshi|Kato, Kiyohito|Iwama, Hisakazu|Fujihara, Shintaro|Nishiyama, Noriko|Mimura, Shima|Toyota, Yuka|Nomura, Takako|Nomura, Kei|Tani, Joji|Miyoshi, Hisaaki|Kobara, Hideki|Mori, Hirohito|Murao, Koji|Masaki, Tsutomu
PMID: 23229592
Journal: Biomed Pharmacother. 2013 Jun;67(5):417-24.
Title: Initiation of apoptosis, cell cycle arrest and autophagy of esophageal cancer cells by dihydroartemisinin.
Author: Du, Xiao-Xue|Li, Yan-Jing|Wu, Chun-Long|Zhou, Jian-Hua|Han, Yu|Sui, Hong|Wei, Xiao-Li|Liu, Lei|Huang, Peng|Yuan, Heng-Heng|Zhang, Ting-Ting|Zhang, Wen-Jie|Xie, Rui|Lang, Xiao-Hui|Jia, De-Xin|Bai, Yu-Xian
PMID: 23582790
Journal: Cancer Sci. 2013 Nov;104(11):1544-51.
Title: Upregulation of Ying Yang 1 (YY1) suppresses esophageal squamous cell carcinoma development through heme oxygenase-1.
Author: Luo, Judong|Zhou, Xifa|Ge, Xin|Liu, Pengfei|Cao, Jianping|Lu, Xujing|Ling, Yang|Zhang, Shuyu
PMID: 23919806
Journal: Int J Oncol. 2015 Jan;46(1):299-307.
Title: Combination of SNX-2112 with 5-FU exhibits antagonistic effect in esophageal cancer cells.
Author: Liu, Yuting|Wang, Xiao|Wang, Ying|Zhang, Yi|Zheng, Kai|Yan, Haizhao|Zhang, Li|Chen, Wenbo|Wang, Xiaoyan|Liu, Qiuying|Wang, Shaoxiang|Wang, Yifei
PMID: 25333998
Journal: Chin J Nat Med. 2015 Jun;13(6):428-37.
Title: Marsdenia tenacissima extract induces G0/G1 cell cycle arrest in human esophageal carcinoma cells by inhibiting mitogen-activated protein kinase (MAPK) signaling pathway.
Author: Fan, Wei|Sun, Li|Zhou, Jing-Qian|Zhang, Cang|Qin, Song|Tang, Ying|Liu, Yang|Lin, Sen-Sen|Yuan, Sheng-Tao
PMID: 26073339
Journal: Int J Mol Med. 2016 Jul;38(1):113-22.
Title: miR-1 suppresses the growth of esophageal squamous cell carcinoma in vivo and in vitro through the downregulation of MET, cyclin D1 and CDK4 expression.
Author: Jiang, Sen|Zhao, Chao|Yang, Xiaodi|Li, Xiangyang|Pan, Qing|Huang, Haijin|Wen, Xuyang|Shan, Husheng|Li, Qianwen|Du, Yunxiang|Zhao, Yaping
PMID: 27247259
Journal: Genet Mol Res. 2016 Jun 3;15(2).
Title: miR-124 radiosensitizes human esophageal cancer cell TE-1 by targeting CDK4.
Author: Zhang, Y H|Wang, Q Q|Li, H|Ye, T|Gao, F|Liu, Y C
PMID: 27323123
Journal: Med Sci Monit. 2016 Jul 25;22:2624-34.
Title: Thioridazine Sensitizes Esophageal Carcinoma Cell Lines to Radiotherapy-Induced Apoptosis In Vitro and In Vivo.
Author: Li, Hongxia|Juan, Li|Xia, Leiming|Wang, Yi|Bao, Yangyi|Sun, Guoping
PMID: 27453171
Journal: Gastroenterol Res Pract. 2016;2016:2968106. Epub 2016 Oct 12.
Title: Identification of the Key Genes and Pathways in Esophageal Carcinoma.
Author: Su, Peng|Wen, Shiwang|Zhang, Yuefeng|Li, Yong|Xu, Yanzhao|Zhu, Yonggang|Lv, Huilai|Zhang, Fan|Wang, Mingbo|Tian, Ziqiang
PMID: 27818681
Journal: Biomed Pharmacother. 2017 Jun;90:517-523.
Title: miRNA-200c enhances radiosensitivity of esophageal cancer by cell cycle arrest and targeting P21.
Author: Zheng, Ruzhen|Liu, Yuehua|Zhang, Xiaoling|Zhao, Pengjun|Deng, Qinghua
PMID: 28402920
Journal: Cancer Sci. 2018 Jan;109(1):193-198.
Title: Phase I study of single-agent ribociclib in Japanese patients with advanced solid tumors.
Author: Doi, Toshihiko|Hewes, Becker|Kakizume, Tomoyuki|Tajima, Takeshi|Ishikawa, Norifumi|Yamada, Yasuhide
PMID: 29059492
Journal: Oncol Rep. 2018 Jan;39(1):71-80.
Title: miR-486 functions as a tumor suppressor in esophageal cancer by targeting CDK4/BCAS2.
Author: Lang, Baoping|Zhao, Song
PMID: 29115564
Journal: Biochem Biophys Res Commun. 2018 Apr 6;498(3):424-430.
Title: Oncogene RPA1 promotes proliferation of hepatocellular carcinoma via CDK4/Cyclin-D pathway.
Author: Wang, Jingcheng|Yang, Tian|Chen, Hui|Li, Hui|Zheng, Shusen
PMID: 29477843