Primary Site >> Esophagus Cancer
Gene >> CDK4
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Ref: MTS-1 (CDKN2) tumor suppressor gene deletions are a frequent event in esophagus squamous cancer and pancreatic adenocarcinoma cell lines. PMID: 7845688 Ref: Intragenic mutations of CDKN2B and CDKN2A in primary human esophageal cancers. PMID: 8595411 |
Ref: [RB gene expression in gastrointestinal tract]. PMID: 8920658 Ref: [The expression of Rb, p16 and cyclin D1 in 41 esophageal cancers]. PMID: 9388858 Ref: Expression of cyclin D1, CDK4 and p27KIP1 is associated with the p16MTS1 gene status in human esophageal carcinoma cell lines. PMID: 9414383 |
Ref: Increased expression of the P27KIP1 protein in human esophageal cancer cell lines that over-express cyclin D1. PMID: 9214595 |
Ref: Effect of cyclin D1 and associated proteins on proliferation of esophageal squamous cell carcinoma. PMID: 9683778 |
Ref: A potential mechanism for fumonisin B(1)-mediated hepatocarcinogenesis: cyclin D1 stabilization associated with activation of Akt and inhibition of GSK-3beta activity. PMID: 10910956 Ref: Early deregulation of the the p16ink4a-cyclin D1/cyclin-dependent kinase 4-retinoblastoma pathway in cell proliferation-driven esophageal tumorigenesis in zinc-deficient rats. PMID: 10969811 |
Ref: Insufficient effect of p27(KIP1) to inhibit cyclin D1 in human esophageal cancer in vitro. PMID: 11115553 |
Ref: MDM2 and CDK4 expression in carcinosarcoma of the esophagus: comparison with squamous cell carcinoma and review of the literature. PMID: 12565795 |
Ref: An alternatively spliced cyclin D1 isoform, cyclin D1b, is a nuclear oncogene. PMID: 14612495 |
Ref: [Flow cytometric detection and significance of four cyclins in esophageal cancer]. PMID: 15634523 |
Ref: Id-1 promotes proliferation of p53-deficient esophageal cancer cells. PMID: 16506209 Ref: Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1. PMID: 16732330 |
Ref: Cytogenetic characterization and gene expression profiling in the rat reflux-induced esophageal tumor model. PMID: 17320581 |
Ref: Characterization of tumor-suppressive function of SOX6 in human esophageal squamous cell carcinoma. PMID: 21084391 Ref: Impaired nuclear export of tumor-derived c-terminal truncated cyclin D1 mutant in ESCC cancer. PMID: 22848289 |
Ref: MSP58 knockdown inhibits the proliferation of esophageal squamous cell carcinoma in vitro and in vivo. PMID: 22994740 |
Ref: Antitumor effect of metformin in esophageal cancer: in vitro study. PMID: 23229592 Ref: Initiation of apoptosis, cell cycle arrest and autophagy of esophageal cancer cells by dihydroartemisinin. PMID: 23582790 Ref: Upregulation of Ying Yang 1 (YY1) suppresses esophageal squamous cell carcinoma development through heme oxygenase-1. PMID: 23919806 |
Ref: Combination of SNX-2112 with 5-FU exhibits antagonistic effect in esophageal cancer cells. PMID: 25333998 Ref: Marsdenia tenacissima extract induces G0/G1 cell cycle arrest in human esophageal carcinoma cells by inhibiting mitogen-activated protein kinase (MAPK) signaling pathway. PMID: 26073339 |
Ref: miR-1 suppresses the growth of esophageal squamous cell carcinoma in vivo and in vitro through the downregulation of MET, cyclin D1 and CDK4 expression. PMID: 27247259 Ref: miR-124 radiosensitizes human esophageal cancer cell TE-1 by targeting CDK4. PMID: 27323123 Ref: Thioridazine Sensitizes Esophageal Carcinoma Cell Lines to Radiotherapy-Induced Apoptosis In Vitro and In Vivo. PMID: 27453171 Ref: Identification of the Key Genes and Pathways in Esophageal Carcinoma. PMID: 27818681 |
Ref: miRNA-200c enhances radiosensitivity of esophageal cancer by cell cycle arrest and targeting P21. PMID: 28402920 |
Ref: Phase I study of single-agent ribociclib in Japanese patients with advanced solid tumors. PMID: 29059492 Ref: miR-486 functions as a tumor suppressor in esophageal cancer by targeting CDK4/BCAS2. PMID: 29115564 Ref: Oncogene RPA1 promotes proliferation of hepatocellular carcinoma via CDK4/Cyclin-D pathway. PMID: 29477843 |