Primary Site >> Colorectal Cancer

Gene >> CDK4

1.
Journal: Cell. 1995 Jul 28;82(2):287-96.
Title: Trypanosome invasion of mammalian cells requires activation of the TGF beta signaling pathway.
Author: Ming, M|Ewen, M E|Pereira, M E
PMID: 7628017
2.
Journal: Nihon Rinsho. 1996 Apr;54(4):965-71.
Title: [RB gene expression in gastrointestinal tract].
Author: Monden, T|Yamamoto, H|Ikeda, K|Izawa, H|Tsujie, M|Ohnishi, T|Miyoshi, Y|Sekimoto, M|Tomita, N|Monden, M
PMID: 8920658
3.
Journal: Nihon Rinsho. 1996 Apr;54(4):1054-9.
Title: [Cyclin D, CDK4 and p16 expression in colorectal cancer].
Author: Ikeda, K|Monden, T|Tsujie, M|Izawa, H|Yamamoto, H|Ohnishi, T|Ohue, M|Sekimoto, M|Tomita, N|Monden, M
PMID: 8920673
4.
Journal: Cancer Res. 1997 May 1;57(9):1638-43.
Title: Decreased transforming growth factor beta type II receptor expression in intestinal adenomas from Min/+ mice is associated with increased cyclin D1 and cyclin-dependent kinase 4 expression.
Author: Zhang, T|Nanney, L B|Peeler, M O|Williams, C S|Lamps, L|Heppner, K J|DuBois, R N|Beauchamp, R D
PMID: 9134999
5.
Journal: Semin Surg Oncol. 1998 Jan-Feb;14(1):3-12.
Title: Molecular changes during the genesis of human gliomas.
Author: Sehgal, A
PMID: 9407626
6.
Journal: Cancer Res. 1998 Jan 1;58(1):109-13.
Title: Novel mutations in the p16/CDKN2A binding region of the cyclin-dependent kinase-4 gene.
Author: Tsao, H|Benoit, E|Sober, A J|Thiele, C|Haluska, F G
PMID: 9426066
7.
Journal: J Biol Chem. 1998 Jan 16;273(3):1662-9.
Title: Disruption of fibronectin binding to the alpha 5 beta 1 integrin stimulates the expression of cyclin-dependent kinases and DNA synthesis through activation of extracellular signal-regulated kinase.
Author: Gong, J|Ko, T C|Brattain, M G
PMID: 9430710
8.
Journal: Int J Oncol. 1998 Sep;13(3):611-7.
Title: gamma-Linolenic acid blocks cell cycle progression by regulating phosphorylation of p27kip1 and p57kip2 and their interactions with other cycle regulators in cancer cells.
Author: Jiang, W G|Bryce, R P|Horrobin, D F|Mansel, R E
PMID: 9683802
9.
Journal: Am J Physiol. 1998 Nov;275(5 Pt 1):C1193-200.
Title: Caco-2 intestinal cell differentiation is associated with G1 arrest and suppression of CDK2 and CDK4.
Author: Ding, Q M|Ko, T C|Evers, B M
PMID: 9814966
10.
Journal: Cancer. 1999 Feb 1;85(3):546-53.
Title: Amplified CDK2 and cdc2 activities in primary colorectal carcinoma.
Author: Kim, J H|Kang, M J|Park, C U|Kwak, H J|Hwang, Y|Koh, G Y
PMID: 10091728
11.
Journal: Mol Cell Biol. 1999 May;19(5):3916-28.
Title: Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a).
Author: Mitra, J|Dai, C Y|Somasundaram, K|El-Deiry, W S|Satyamoorthy, K|Herlyn, M|Enders, G H
PMID: 10207115
12.
Journal: Anticancer Res. 1999 Jan-Feb;19(1B):741-8.
Title: Differential cyclin-dependent kinase expression and activation in human colon cancer.
Author: Salh, B|Bergman, D|Marotta, A|Pelech, S L
PMID: 10216486
13.
Journal: Exp Cell Res. 1999 Jun 15;249(2):240-7.
Title: NA22598, a novel antitumor compound, reduces cyclin D1 levels, arrests cell cycle at G1 phase, and inhibits anchorage-independent growth of human tumor cells.
Author: Kawada, M|Kuwahara, A|Nishikiori, T|Mizuno, S|Uehara, Y
PMID: 10366423
14.
Journal: Curr Pharm Des. 2000 Mar;6(4):379-92.
Title: Cell cycle molecular targets in novel anticancer drug discovery.
Author: Buolamwini, J K
PMID: 10788588
15.
Journal: Mol Cell Biol Res Commun. 2000 Jun;3(6):352-9.
Title: Downregulation of cyclin D1 alters cdk 4- and cdk 2-specific phosphorylation of retinoblastoma protein.
Author: Yu, B|Lane, M E|Pestell, R G|Albanese, C|Wadler, S
PMID: 11032757
16.
Journal: Cancer Chemother Pharmacol. 2000;46(4):293-304.
Title: Expression of pRB, cyclin/cyclin-dependent kinases and E2F1/DP-1 in human tumor lines in cell culture and in xenograft tissues and response to cell cycle agents.
Author: Lu, K|Shih, C|Teicher, B A
PMID: 11052627
17.
Journal: J Antibiot (Tokyo). 2000 Oct;53(10):1191-200.
Title: Mechanism of cell cycle arrest caused by histone deacetylase inhibitors in human carcinoma cells.
Author: Kim, Y B|Ki, S W|Yoshida, M|Horinouchi, S
PMID: 11132966
18.
Journal: Cancer Res. 2001 Jan 15;61(2):565-9.
Title: Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosal.
Author: Yang, W C|Mathew, J|Velcich, A|Edelmann, W|Kucherlapati, R|Lipkin, M|Yang, K|Augenlicht, L H
PMID: 11212250
19.
Journal: J Natl Cancer Inst. 2001 Mar 21;93(6):436-46.
Title: Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4.
Author: Soni, R|O'Reilly, T|Furet, P|Muller, L|Stephan, C|Zumstein-Mecker, S|Fretz, H|Fabbro, D|Chaudhuri, B
PMID: 11259469
20.
Journal: J Nutr. 2001 Aug;131(8):2197-203.
Title: Downregulation of the cyclin D1/Cdk4 complex occurs during resveratrol-induced cell cycle arrest in colon cancer cell lines.
Author: Wolter, F|Akoglu, B|Clausnitzer, A|Stein, J
PMID: 11481417
21.
Journal: Toxicol Appl Pharmacol. 2002 Apr 1;180(1):22-35.
Title: Antitumor effects of miconazole on human colon carcinoma xenografts in nude mice through induction of apoptosis and G0/G1 cell cycle arrest.
Author: Wu, Chih-Hsiung|Jeng, Jiiang-Huei|Wang, Ying-Jan|Tseng, Chia-Jen|Liang, Yu-Chih|Chen, Chien-Ho|Lee, Horng-Mo|Lin, Jen-Kun|Lin, Chien-Huang|Lin, Shyr-Yi|Li, Chung-Pei|Ho, Yuan-Soon
PMID: 11922774
22.
Journal: Cancer Lett. 2002 Jul 26;181(2):187-94.
Title: Monoterpenes inhibit proliferation of human colon cancer cells by modulating cell cycle-related protein expression.
Author: Bardon, Sylvie|Foussard, Valerie|Fournel, Sophie|Loubat, Agnes
PMID: 12175534
23.
Journal: Biochem Pharmacol. 2002 Oct 1;64(7):1091-100.
Title: SU9516, a cyclin-dependent kinase 2 inhibitor, promotes accumulation of high molecular weight E2F complexes in human colon carcinoma cells.
Author: Yu, Bo|Lane, Maureen E|Wadler, Scott
PMID: 12234612
24.
Journal: Carcinogenesis. 2002 Oct;23(10):1677-84.
Title: Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells.
Author: Pan, Min-Hsiung|Chen, Wei-Jen|Lin-Shiau, Shoei-Yn|Ho, Chi-Tang|Lin, Jen-Kun
PMID: 12376477
25.
Journal: J Med Chem. 2002 Nov 21;45(24):5224-32.
Title: Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 2. Probing the indeno ring substituent pattern.
Author: Nugiel, David A|Vidwans, Anup|Etzkorn, Anna-Marie|Rossi, Karen A|Benfield, Pamela A|Burton, Catherine R|Cox, Sarah|Doleniak, Deborah|Seitz, Steven P
PMID: 12431050
26.
Journal: Eur J Cancer. 2002 Dec;38(18):2446-54.
Title: Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest.
Author: Murillo, G|Salti, G I|Kosmeder, J W 2nd|Pezzuto, J M|Mehta, R G
PMID: 12460790
27.
Journal: Cancer Cell. 2003 Mar;3(3):233-45.
Title: Proliferation of cancer cells despite CDK2 inhibition.
Author: Tetsu, Osamu|McCormick, Frank
PMID: 12676582
28.
Journal: Beijing Da Xue Xue Bao. 2003 Feb 18;35(1):50-3.
Title: [Stat3 signal transduction pathway orchestrates G1 to S cell cycle transition in colon cancer cells].
Author: Ma, Xiangtao|Wang, Shan|Du, Ruyu|Ye, Yingjiang|Wang, Shu|Yan, Feifei|Cui, Zhirong
PMID: 12920809
29.
Journal: J Biol Chem. 2003 Oct 31;278(44):43586-94. Epub 2003 Aug 19.
Title: p21-dependent inhibition of colon cancer cell growth by mevastatin is independent of inhibition of G1 cyclin-dependent kinases.
Author: Ukomadu, Chinweike|Dutta, Anindya
PMID: 12930830
30.
Journal: World J Gastroenterol. 2003 Oct;9(10):2202-6.
Title: Expressing patterns of p16 and CDK4 correlated to prognosis in colorectal carcinoma.
Author: Zhao, Po|Hu, Ying-Chuan|Talbot, Ian C
PMID: 14562378
31.
Journal: Oncogene. 2003 Nov 13;22(51):8271-82.
Title: Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells.
Author: Agarwal, Chapla|Singh, Rana P|Dhanalakshmi, Sivanandhan|Tyagi, Anil K|Tecklenburg, Marianne|Sclafani, Robert A|Agarwal, Rajesh
PMID: 14614451
32.
Journal: Cancer Res. 2004 Jan 1;64(1):262-72.
Title: The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway.
Author: Whittaker, Steven R|Walton, Mike I|Garrett, Michelle D|Workman, Paul
PMID: 14729633
33.
Journal: Cancer Res. 2004 Jun 1;64(11):3885-91.
Title: Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1.
Author: Benzeno, Sharon|Narla, Goutham|Allina, Jorge|Cheng, George Z|Reeves, Helen L|Banck, Michaela S|Odin, Joseph A|Diehl, J Alan|Germain, Doris|Friedman, Scott L
PMID: 15172998
34.
Journal: Int J Oncol. 2004 Jul;25(1):231-6.
Title: Synthetic bile acid derivatives inhibit cell proliferation and induce apoptosis in HT-29 human colon cancer cells.
Author: Park, Sang Eun|Choi, Hye Joung|Yee, Su Bog|Chung, Hae Young|Suh, Hongsuk|Choi, Yung Hyun|Yoo, Young Hyun|Kim, Nam Deuk
PMID: 15202011
35.
Journal: Mol Cancer Ther. 2004 Jun;3(6):755-62.
Title: Identification of 4-anilino-3-quinolinecarbonitrile inhibitors of mitogen-activated protein/extracellular signal-regulated kinase 1 kinase.
Author: Mallon, Robert|Feldberg, Larry|Kim, Steven|Collins, Karen|Wojciechowicz, Donald|Kohler, Constance|Kovacs, Diana|Discafani, Carolyn|Zhang, Nan|Wu, Biqi|Floyd, Brawner|Powell, Dennis|Berger, Dan
PMID: 15210862
36.
Journal: J Biol Chem. 2004 Sep 17;279(38):40237-44. Epub 2004 Jul 22.
Title: Autocrine and exogenous transforming growth factor beta control cell cycle inhibition through pathways with different sensitivity.
Author: Wang, Jing|Sergina, Natalia|Ko, Tien C|Gong, Jiangeng|Brattain, Michael G
PMID: 15271980
37.
Journal: Am J Physiol Cell Physiol. 2004 Dec;287(6):C1541-6. Epub 2004 Aug 18.
Title: Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1).
Author: Goke, R|Barth, P|Schmidt, A|Samans, B|Lankat-Buttgereit, B
PMID: 15317660
38.
Journal: World J Gastroenterol. 2004 Dec 1;10(23):3441-54.
Title: Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
Author: Xu, Xiao-Li|Yu, Jian|Zhang, Hong-Yu|Sun, Meng-Hong|Gu, Jun|Du, Xiang|Shi, Da-Ren|Wang, Peng|Yang, Zhen-Hua|Zhu, Jing-De
PMID: 15526363
39.
Journal: Mol Cancer Ther. 2004 Nov;3(11):1427-38.
Title: Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts.
Author: Fry, David W|Harvey, Patricia J|Keller, Paul R|Elliott, William L|Meade, Maryanne|Trachet, Erin|Albassam, Mudher|Zheng, XianXian|Leopold, Wilbur R|Pryer, Nancy K|Toogood, Peter L
PMID: 15542782
40.
Journal: Cancer Res. 2004 Dec 15;64(24):9086-92.
Title: Tetrandrine induces early G1 arrest in human colon carcinoma cells by down-regulating the activity and inducing the degradation of G1-S-specific cyclin-dependent kinases and by inducing p53 and p21Cip1.
Author: Meng, Ling-Hua|Zhang, Hongliang|Hayward, Larry|Takemura, Haruyuki|Shao, Rong-Guang|Pommier, Yves
PMID: 15604277
41.
Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004 Jun;29(3):261-5.
Title: [Effects of celecoxib on the proliferation and apoptosis of human colorectal cancer cell line HT-29].
Author: Peng, Jie|Zhang, Gui-Ying|Xiao, Zhi-Qiang
PMID: 16136956
42.
Journal: Eur J Nutr. 2005 Mar;44(3):143-56.
Title: Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro.
Author: van Erk, Marjan J|Roepman, Paul|van der Lende, Ted R|Stierum, Rob H|Aarts, Jac M M J G|van Bladeren, Peter J|van Ommen, Ben
PMID: 15309432
43.
Journal: J Biol Chem. 2005 Mar 4;280(9):7634-44. Epub 2004 Dec 17.
Title: Tumor necrosis factor alpha-dependent drug resistance to purine and pyrimidine analogues in human colon tumor cells mediated through IKK.
Author: Wang, Ling-Chi|Okitsu, Cindy Yen|Zandi, Ebrahim
PMID: 15611081
44.
Journal: World J Gastroenterol. 2005 Mar 21;11(11):1693-6.
Title: Effect of indomethacin on cell cycle proteins in colon cancer cell lines.
Author: Xu, Mei-Hua|Zhang, Gui-Ying
PMID: 15786552
45.
Journal: Cancer Chemother Pharmacol. 2005 Aug;56(2):126-37.
Title: Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models.
Author: Smith, Victoria|Sausville, Edward A|Camalier, Richard F|Fiebig, Heinz-Herbert|Burger, Angelika M
PMID: 15841378
46.
Journal: J Cell Physiol. 2005 Oct;205(1):107-13.
Title: Inhibition of colon cancer cell proliferation by the dietary compound conjugated linoleic acid is mediated by the CDK inhibitor p21CIP1/WAF1.
Author: Lim, Do Y|Tyner, Angela L|Park, Jae-Bong|Lee, Jae-Yong|Choi, Yung H|Park, Jung H Y
PMID: 15880444
47.
Journal: Food Chem Toxicol. 2005 Oct;43(10):1483-95.
Title: Molecular mechanisms of econazole-induced toxicity on human colon cancer cells: G0/G1 cell cycle arrest and caspase 8-independent apoptotic signaling pathways.
Author: Ho, Yuan-Soon|Wu, Chih-Hsiung|Chou, Hsiao-Min|Wang, Ying-Jan|Tseng, How|Chen, Chien-Ho|Chen, Li-Ching|Lee, Chia-Hwa|Lin, Shyr-Yi
PMID: 15919146
48.
Journal: Exp Cell Res. 2005 Jul 1;307(1):231-46. Epub 2005 Apr 19.
Title: Smad7 induces tumorigenicity by blocking TGF-beta-induced growth inhibition and apoptosis.
Author: Halder, Sunil K|Beauchamp, R Daniel|Datta, Pran K
PMID: 15922743
49.
Journal: Cell Cycle. 2005 Sep;4(9):1201-15.
Title: Molecular targets and anticancer potential of indole-3-carbinol and its derivatives.
Author: Aggarwal, Bharat B|Ichikawa, Haruyo
PMID: 16082211
50.
Journal: FEBS Lett. 2005 Dec 5;579(29):6604-10.
Title: Escherichia coli verotoxin 1 mediates apoptosis in human HCT116 colon cancer cells by inducing overexpression of the GADD family of genes and S phase arrest.
Author: Bhattacharjee, Rabindra N|Park, Kwon-Sam|Uematsu, Satoshi|Okada, Kazuhisa|Hoshino, Katsuaki|Takeda, Kiyoshi|Takeuchi, Osamu|Akira, Shizuo|Iida, Tetsuya|Honda, Takeshi
PMID: 16297916
51.
Journal: J Nutr. 2005 Dec;135(12):2884-90.
Title: Fisetin inhibits the activities of cyclin-dependent kinases leading to cell cycle arrest in HT-29 human colon cancer cells.
Author: Lu, Xianghua|Jung, Jae in|Cho, Han Jin|Lim, Do Young|Lee, Hyun Sook|Chun, Hyang Sook|Kwon, Dae Young|Park, Jung Han Yoon
PMID: 16317137
52.
Journal: World J Gastroenterol. 2005 Dec 7;11(45):7211-7.
Title: Correlation between the expressions of gastrin, somatostatin and cyclin and cyclin-depend kinase in colorectal cancer.
Author: Wu, Pei|Mao, Jia-Ding|Yan, Jing-Yi|Rui, Jing|Zhao, You-Cai|Li, Xian-Hai|Xu, Guo-Qiang
PMID: 16437675
53.
Journal: Int J Cancer. 2006 Feb 1;118(3):600-8.
Title: Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations.
Author: Grady, William M|Willis, Joseph E|Trobridge, Patty|Romero-Gallo, Judith|Munoz, Nina|Olechnowicz, Joseph|Ferguson, Kelly|Gautam, Shiva|Markowitz, Sanford D
PMID: 16108056
54.
Journal: Oncogene. 2006 May 25;25(22):3123-38.
Title: Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators.
Author: Cerda, S R|Mustafi, R|Little, H|Cohen, G|Khare, S|Moore, C|Majumder, P|Bissonnette, M
PMID: 16434969
55.
Journal: J Nutr. 2006 Apr;136(4):893-8.
Title: Trans-10,cis-12, not cis-9,trans-11, conjugated linoleic acid inhibits G1-S progression in HT-29 human colon cancer cells.
Author: Cho, Han Jin|Kim, Eun Ji|Lim, Soon Sung|Kim, Mi Kyung|Sung, Mi-Kyung|Kim, Jong-Sang|Park, Jung Han Yoon
PMID: 16549447
56.
Journal: Glycobiology. 2006 Jul;16(7):573-83. Epub 2006 Mar 30.
Title: Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway.
Author: Choi, Hee-Jung|Chung, Tae-Wook|Kang, Sung-Koo|Lee, Young-Choon|Ko, Jeong-Heon|Kim, Jong-Guk|Kim, Cheorl-Ho
PMID: 16574813
57.
Journal: Zhonghua Yi Xue Za Zhi. 2006 Mar 28;86(12):846-9.
Title: [Antisense to CDK4 inhibits the growth of human colon cancer cells HT29].
Author: Ye, Ying-jiang|Zhu, Xue-guang|Wang, Shan|Wang, Yong-chao|Sang, Jian-li
PMID: 16681978
58.
Journal: J Med Chem. 2006 Nov 2;49(22):6549-60.
Title: Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity.
Author: Chu, Xin-Jie|DePinto, Wanda|Bartkovitz, David|So, Sung-Sau|Vu, Binh T|Packman, Kathryn|Lukacs, Christine|Ding, Qingjie|Jiang, Nan|Wang, Ka|Goelzer, Petra|Yin, Xuefeng|Smith, Melissa A|Higgins, Brian X|Chen, Yingsi|Xiang, Qing|Moliterni, John|Kaplan, Geral
PMID: 17064073
59.
Journal: World J Gastroenterol. 2006 Oct 21;12(39):6391-6.
Title: Aberrant cytological localization of p16 and CDK4 in colorectal epithelia in the normal adenoma carcinoma sequence.
Author: Zhao, Po|Mao, Xin|Talbot, Ian C
PMID: 17072968
60.
Journal: Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G66-75.
Title: Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin.
Author: Lim, Do Y|Jeong, Yoonhwa|Tyner, Angela L|Park, Jung H Y
PMID: 16901994
61.
Journal: Food Chem Toxicol. 2007 Jun;45(6):935-44.
Title: Induction of apoptosis and cell-cycle arrest in human colon cancer cells by meclizine.
Author: Lin, Jiunn-Chang|Ho, Yuan-Soon|Lee, Jie-Jen|Liu, Chien-Liang|Yang, Tsen-Long|Wu, Chih-Hsiung
PMID: 17222494
62.
Journal: Cancer Res. 2007 Feb 15;67(4):1660-9.
Title: p38-mediated inactivation of cyclin D1/cyclin-dependent kinase 4 stimulates nucleolar translocation of RelA and apoptosis in colorectal cancer cells.
Author: Thoms, Hazel C|Dunlop, Malcolm G|Stark, Lesley A
PMID: 17308107
63.
Journal: Oncol Rep. 2007 May;17(5):1061-5.
Title: Gene profile analysis of colorectal cancer cell lines by cDNA macroarray.
Author: Saito, Noboru|Kameoka, Shingo|Furukawa, Ryuji
PMID: 17390045
64.
Journal: Oncogene. 2007 Oct 18;26(48):6954-8. Epub 2007 May 7.
Title: p21(Waf1/Cip1/Sdi1) mediates retinoblastoma protein degradation.
Author: Broude, E V|Swift, M E|Vivo, C|Chang, B-D|Davis, B M|Kalurupalle, S|Blagosklonny, M V|Roninson, I B
PMID: 17486059
65.
Journal: Cell Cycle. 2007 Jun 1;6(11):1293-7. Epub 2007 Jun 19.
Title: CDK4 inhibitors and apoptosis: a novel mechanism requiring nucleolar targeting of RelA.
Author: Thoms, Hazel C|Dunlop, Malcolm G|Stark, Lesley A
PMID: 17525529
66.
Journal: Cancer Res. 2007 Sep 1;67(17):8325-34.
Title: Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases.
Author: Bettayeb, Karima|Tirado, Oscar M|Marionneau-Lambot, Severine|Ferandin, Yoan|Lozach, Olivier|Morris, Jonathan C|Mateo-Lozano, Silvia|Drueckes, Peter|Schachtele, Christoph|Kubbutat, Michael H G|Liger, Francois|Marquet, Bernard|Joseph, Benoit|Echalier, Aude|
PMID: 17804748
67.
Journal: Biochim Biophys Acta. 2008 Apr;1780(4):743-9.
Title: Growth inhibition of human hepatic carcinoma HepG2 cells by fucoxanthin is associated with down-regulation of cyclin D.
Author: Das, Swadesh K|Hashimoto, Takashi|Kanazawa, Kazuki
PMID: 18230364
68.
Journal: Int J Clin Pharmacol Ther. 2008 May;46(5):226-35.
Title: Mucronulatol from Caribbean propolis exerts cytotoxic effects on human tumor cell lines.
Author: Diaz-Carballo, D|Freista Hler, M|Malak, S|Bardenheuer, W|Reusch, H P
PMID: 18538108
69.
Journal: Am J Pathol. 2008 Aug;173(2):518-25.
Title: Role of human aquaporin 5 in colorectal carcinogenesis.
Author: Kang, Sung Koo|Chae, Young Kwang|Woo, Janghee|Kim, Myoung Sook|Park, Jong Chul|Lee, Juna|Soria, Jean Charles|Jang, Se Jin|Sidransky, David|Moon, Chulso
PMID: 18583321
70.
Journal: Chem Biol Interact. 2008 Aug 11;174(3):201-10.
Title: Inhibition of cell-cycle progression in human colorectal carcinoma Lovo cells by andrographolide.
Author: Shi, Ming-Der|Lin, Hui-Hsuan|Lee, Yi-Che|Chao, Jian-Kang|Lin, Rong-An|Chen, Jing-Hsien
PMID: 18619950
71.
Journal: Br J Pharmacol. 2008 Nov;155(5):641-54.
Title: Benzylidene derivatives of andrographolide inhibit growth of breast and colon cancer cells in vitro by inducing G(1) arrest and apoptosis.
Author: Jada, S R|Matthews, C|Saad, M S|Hamzah, A S|Lajis, N H|Stevens, M F G|Stanslas, J
PMID: 18806812
72.
Journal: Oncogene. 2009 Jan 15;28(2):157-69.
Title: Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors.
Author: Smith, J R|Clarke, P A|de Billy, E|Workman, P
PMID: 18931700
73.
Journal: Gut. 2009 Mar;58(3):413-20.
Title: Cell kinetics and gene expression changes in colorectal cancer patients given resistant starch: a randomised controlled trial.
Author: Dronamraju, S S|Coxhead, J M|Kelly, S B|Burn, J|Mathers, J C
PMID: 18978177
74.
Journal: Gastroenterology. 2009 May;136(5):1680-8.e7.
Title: TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway.
Author: Trobridge, Patty|Knoblaugh, Sue|Washington, M Kay|Munoz, Nina M|Tsuchiya, Karen D|Rojas, Andres|Song, Xiaoling|Ulrich, Cornelia M|Sasazuki, Takehiko|Shirasawa, Senji|Grady, William M
PMID: 19208363
75.
Journal: Anticancer Res. 2009 Jan;29(1):395-401.
Title: Curcumin synergizes the growth inhibitory properties of Indian toad (Bufo melanostictus Schneider) skin-derived factor (BM-ANF1) in HCT-116 colon cancer cells.
Author: Giri, Biplab|Gomes, Antony|Sengupta, Radha|Banerjee, Sanjeev|Nautiyal, Jyoti|Sarkar, Fazlul H|Majumdar, Adhip P N
PMID: 19331178
76.
Journal: BMC Gastroenterol. 2009 May 29;9:39.
Title: Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cells.
Author: Choi, Hyun Ju|Lim, Do Young|Park, Jung Han Yoon
PMID: 19480695
77.
Journal: Cancer Res. 2009 Jul 1;69(13):5321-30.
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Title: Role of SMC1A overexpression as a predictor of poor prognosis in late stage colorectal cancer.
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Title: [Mechanism of thioridazine-induced apoptosis of human colorectal cancer SW480 cells].
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Title: Smad2/3 linker phosphorylation is a possible marker of cancer stem cells and correlates with carcinogenesis in a mouse model of colitis-associated colorectal cancer.
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Title: Exome Sequencing of Normal and Isogenic Transformed Human Colonic Epithelial Cells (HCECs) Reveals Novel Genes Potentially Involved in the Early Stages of Colorectal Tumorigenesis.
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Title: Targeting of multiple oncogenic signaling pathways by Hsp90 inhibitor alone or in combination with berberine for treatment of colorectal cancer.
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Title: Growth inhibitory and chemo-sensitization effects of naringenin, a natural flavanone purified from Thymus vulgaris, on human breast and colorectal cancer.
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Title: Jianpi Huayu Decoction Inhibits Proliferation in Human Colorectal Cancer Cells (SW480) by Inducing G0/G1-Phase Cell Cycle Arrest and Apoptosis.
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Title: Anticolorectal cancer effects and pharmacokinetic application of 2, 2-Bis [4-(4-amino-3-hydroxyphenoxy) phenyl] adamantane.
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Journal: Clin Cancer Res. 2016 Jan 15;22(2):405-14.
Title: Sensitivity of KRAS-Mutant Colorectal Cancers to Combination Therapy That Cotargets MEK and CDK4/6.
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Journal: Oncotarget. 2016 Jan 5;7(1):961-75.
Title: Knockdown of linc-POU3F3 suppresses the proliferation, apoptosis, and migration resistance of colorectal cancer.
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Title: Dual inhibition of COX-2/5-LOX blocks colon cancer proliferation, migration and invasion in vitro.
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Title: Pristimerin demonstrates anticancer potential in colorectal cancer cells by inducing G1 phase arrest and apoptosis and suppressing various pro-survival signaling proteins.
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Journal: Neoplasma. 2016;63(2):193-200.
Title: Chidamide and 5-flurouracil show a synergistic antitumor effect on human colon cancer xenografts in nude mice.
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Title: Anti-tumor role of Bacillus subtilis fmbJ-derived fengycin on human colon cancer HT29 cell line.
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Title: Phosphorylated retinoblastoma protein is a potential predictive marker of irinotecan efficacy for colorectal cancer.
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Journal: PLoS One. 2016 Feb 9;11(2):e0148775.
Title: Flavokawain C Inhibits Cell Cycle and Promotes Apoptosis, Associated with Endoplasmic Reticulum Stress and Regulation of MAPKs and Akt Signaling Pathways in HCT 116 Human Colon Carcinoma Cells.
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Journal: Cell Biol Int. 2016 May;40(5):560-8.
Title: The AhR is involved in the regulation of LoVo cell proliferation through cell cycle-associated proteins.
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Title: SRJ09, a promising anticancer drug lead: Elucidation of mechanisms of antiproliferative and apoptogenic effects and assessment of in vivo antitumor efficacy.
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Title: Deoxyelephantopin from Elephantopus scaber Inhibits HCT116 Human Colorectal Carcinoma Cell Growth through Apoptosis and Cell Cycle Arrest.
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Title: Efficacy of the combination of MEK and CDK4/6 inhibitors in vitro and in vivo in KRAS mutant colorectal cancer models.
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Title: microRNA-374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway.
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Journal: Cancer Discov. 2016 Jul;6(7):740-53.
Title: Efficacy and Safety of Abemaciclib, an Inhibitor of CDK4 and CDK6, for Patients with Breast Cancer, Non-Small Cell Lung Cancer, and Other Solid Tumors.
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Title: An Association Map on the Effect of Flavonoids on the Signaling Pathways in Colorectal Cancer.
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Title: CDK4/6 Inhibitors: Promising Opportunities beyond Breast Cancer.
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Title: Downregulation of CREB Promotes Cell Proliferation by Mediating G1/S Phase Transition in Hodgkin Lymphoma.
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Title: Secoisolariciresinol diglucoside rich extract of L. usitatissimum prevents diabetic colon cancer through inhibition of CDK4.
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Title: Anti-cancer activity of Psoralea fructus through the downregulation of cyclin D1 and CDK4 in human colorectal cancer cells.
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Journal: J Agric Food Chem. 2016 Oct 11.
Title: Stereoisomers of Astaxanthin Inhibit Human Colon Cancer Cell Growth by Inducing G2/M Cell Cycle Arrest and Apoptosis.
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Title: High expression of CREPT promotes tumor growth and is correlated with poor prognosis in colorectal cancer.
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Title: c-Myc is regulated by HIF-2alpha in chronic hypoxia and influences sensitivity to 5-FU in colon cancer.
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Journal: Mol Carcinog. 2017 Jan;56(1):18-35.
Title: Lebein, a snake venom disintegrin, suppresses human colon cancer cells proliferation and tumor-induced angiogenesis through cell cycle arrest, apoptosis induction and inhibition of VEGF expression.
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Title: pathTiMEx: Joint Inference of Mutually Exclusive Cancer Pathways and Their Progression Dynamics.
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Journal: Food Funct. 2017 Mar 22;8(3):1052-1060.
Title: Identification of terpenoids from Rubus corchorifolius L. f. leaves and their anti-proliferative effects on human cancer cells.
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Title: Novel ent-Kaurane Diterpenoid from Rubus corchorifolius L. f. Inhibits Human Colon Cancer Cell Growth via Inducing Cell Cycle Arrest and Apoptosis.
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Title: LncRNA SNHG12 promotes cell growth and inhibits cell apoptosis in colorectal cancer cells.
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Title: Cell-Cycle Regulation Accounts for Variability in Ki-67 Expression Levels.
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Journal: Cell Cycle. 2017 Jun 18;16(12):1193-1200.
Title: The CDK4/6 inhibitor palbociclib synergizes with irinotecan to promote colorectal cancer cell death under hypoxia.
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Journal: Mar Drugs. 2017 May 30;15(6). pii: md15060154.
Title: Induction of p53-Independent Apoptosis and G1 Cell Cycle Arrest by Fucoidan in HCT116 Human Colorectal Carcinoma Cells.
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Journal: Oncol Rep. 2017 Jul;38(1):31-42.
Title: Synthetic lethal interaction of CDK inhibition and autophagy inhibition in human solid cancer cell lines.
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Journal: Gene. 2017 Sep 5;627:255-262.
Title: ICT1 predicts a poor survival and correlated with cell proliferation in diffuse large B-cell lymphoma.
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Title: Ursodeoxycholic acid inhibits the proliferation of colon cancer cells by regulating oxidative stress and cancer stem-like cell growth.
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Title: Mertensene, a Halogenated Monoterpene, Induces G2/M Cell Cycle Arrest and Caspase Dependent Apoptosis of Human Colon Adenocarcinoma HT29 Cell Line through the Modulation of ERK-1/-2, AKT and NF-kappaB Signaling.
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Journal: Anticancer Drugs. 2017 Sep;28(8):831-840.
Title: Synergistic antitumor effect of 3-bromopyruvate and 5-fluorouracil against human colorectal cancer through cell cycle arrest and induction of apoptosis.
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Title: Inhibition of cell cycle progression by the hydroxytyrosol-cetuximab combination yields enhanced chemotherapeutic efficacy in colon cancer cells.
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Title: [Effects of LncRNA H19 on Proliferation of Human Colorectal Cancer SW620 Cells].
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Title: Curcumol induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3beta/cyclin D1 pathway.
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Journal: Biomol Ther (Seoul). 2018 May 1;26(3):313-321.
Title: Cellular Prion Protein Enhances Drug Resistance of Colorectal Cancer Cells via Regulation of a Survival Signal Pathway.
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Title: Simvastatin induces G1 arrest by up-regulating GSK3beta and down-regulating CDK4/cyclin D1 and CDK2/cyclin E1 in human primary colorectal cancer cells.
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Journal: Mol Med Rep. 2018 Jan;17(1):358-365.
Title: Hedyotis diffusa Willd inhibits proliferation and induces apoptosis of 5FU resistant colorectal cancer cells by regulating the PI3K/AKT signaling pathway.
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Journal: Cell Metab. 2018 Jan 9;27(1):118-135.e8.
Title: mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis.
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Journal: Cancer Sci. 2018 Mar;109(3):656-665.
Title: Cdc37 facilitates cell survival of colorectal carcinoma via activating the CDK4 signaling pathway.
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Journal: Am J Chin Med. 2018;46(1):191-207.
Title: Vitex rotundifolia Fruit Suppresses the Proliferation of Human Colorectal Cancer Cells through Down-regulation of Cyclin D1 and CDK4 via Proteasomal-Dependent Degradation and Transcriptional Inhibition.
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Title: Oncogene RPA1 promotes proliferation of hepatocellular carcinoma via CDK4/Cyclin-D pathway.
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Journal: J Enzyme Inhib Med Chem. 2018 Dec;33(1):546-557.
Title: Anticancer evaluation and molecular modeling of multi-targeted kinase inhibitors based pyrido[2,3-d]pyrimidine scaffold.
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Journal: Cell Prolif. 2018 Aug;51(4):e12451.
Title: Coroglaucigenin induces senescence and autophagy in colorectal cancer cells.
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Title: Expression of factors and key components associated with the PI3K signaling pathway in colon cancer.
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Journal: Food Funct. 2018 Apr 25;9(4):2145-2157.
Title: The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. Part 1: the suppression of cell proliferation, promotion of apoptosis and arrest of the cell cycle.
Author: Afrin, Sadia|Giampieri, Francesca|Gasparrini, Massimiliano|Forbes-Hernandez, Tamara Y|Cianciosi, Danila|Reboredo-Rodriguez, Patricia|Amici, Adolfo|Quiles, Jose L|Battino, Maurizio
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Journal: Biomed Pharmacother. 2018 Jun;102:1037-1044.
Title: Astragaloside IV inhibits cell proliferation of colorectal cancer cell lines through down-regulation of B7-H3.
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Title: [Role of allograft inflammatory factor-1 in regulating the proliferation, migration and apoptosis of colorectal cancer cells].
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Title: Triggering of cancer cell cycle arrest by a novel scorpion venom-derived peptide-Gonearrestide.
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Title: Anti-inflammation and Anti-Cancer Activity of Ethanol Extract of Antarctic Freshwater Microalga, Micractinium sp.
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Title: Total ginsenosides of Chinese ginseng induces cell cycle arrest and apoptosis in colorectal carcinoma HT-29 cells.
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Journal: Front Pharmacol. 2018 Aug 29;9:986.
Title: Gomisin A Suppresses Colorectal Lung Metastasis by Inducing AMPK/p38-Mediated Apoptosis and Decreasing Metastatic Abilities of Colorectal Cancer Cells.
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Title: Evaluation of the effect of 2-(2,4-dihydroxyphenyl)-4H-benzofuro[3,2-d][1,3]thiazin-4-one on colon cells and its anticancer potential.
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Title: Baicalein Inhibits Proliferation Activity of Human Colorectal Cancer Cells HCT116 Through Downregulation of Ezrin.
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Journal: Bull Cancer. 2018 Oct 8. pii: S0007-4551(18)30275-3.
Title: PTBP1 promotes tumorigenesis by regulating apoptosis and cell cycle in colon cancer.
Author: Li, Xiaona|Han, Fei|Liu, Wenbin|Shi, Xiaoyan
PMID: 30309622
218.
Journal: Pharmaceutics. 2018 Oct 23;10(4). pii: pharmaceutics10040198.
Title: An Intrinsic Mitochondrial Pathway Is Required for Phytic Acid-Chitosan-Iron Oxide Nanocomposite (Phy-CS-MNP) to Induce G(0)/G(1) Cell Cycle Arrest and Apoptosis in the Human Colorectal Cancer (HT-29) Cell Line.
Author: Tan, Bee Ling|Norhaizan, Mohd Esa|Chan, Lee Chin
PMID: 30360519