Primary Site >> Colorectal Cancer
Gene >> CDK4
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Trypanosome invasion of mammalian cells requires activation of the TGF beta signaling pathway. PMID: 7628017 |
Ref: [RB gene expression in gastrointestinal tract]. PMID: 8920658 Ref: [Cyclin D, CDK4 and p16 expression in colorectal cancer]. PMID: 8920673 |
Ref: Decreased transforming growth factor beta type II receptor expression in intestinal adenomas from Min/+ mice is associated with increased cyclin D1 and cyclin-dependent kinase 4 expression. PMID: 9134999 |
Ref: Molecular changes during the genesis of human gliomas. PMID: 9407626 Ref: Novel mutations in the p16/CDKN2A binding region of the cyclin-dependent kinase-4 gene. PMID: 9426066 Ref: Disruption of fibronectin binding to the alpha 5 beta 1 integrin stimulates the expression of cyclin-dependent kinases and DNA synthesis through activation of extracellular signal-regulated kinase. PMID: 9430710 Ref: gamma-Linolenic acid blocks cell cycle progression by regulating phosphorylation of p27kip1 and p57kip2 and their interactions with other cycle regulators in cancer cells. PMID: 9683802 Ref: Caco-2 intestinal cell differentiation is associated with G1 arrest and suppression of CDK2 and CDK4. PMID: 9814966 |
Ref: Amplified CDK2 and cdc2 activities in primary colorectal carcinoma. PMID: 10091728 Ref: Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a). PMID: 10207115 Ref: Differential cyclin-dependent kinase expression and activation in human colon cancer. PMID: 10216486 Ref: NA22598, a novel antitumor compound, reduces cyclin D1 levels, arrests cell cycle at G1 phase, and inhibits anchorage-independent growth of human tumor cells. PMID: 10366423 |
Ref: Cell cycle molecular targets in novel anticancer drug discovery. PMID: 10788588 Ref: Downregulation of cyclin D1 alters cdk 4- and cdk 2-specific phosphorylation of retinoblastoma protein. PMID: 11032757 Ref: Expression of pRB, cyclin/cyclin-dependent kinases and E2F1/DP-1 in human tumor lines in cell culture and in xenograft tissues and response to cell cycle agents. PMID: 11052627 Ref: Mechanism of cell cycle arrest caused by histone deacetylase inhibitors in human carcinoma cells. PMID: 11132966 |
Ref: Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosal. PMID: 11212250 Ref: Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4. PMID: 11259469 Ref: Downregulation of the cyclin D1/Cdk4 complex occurs during resveratrol-induced cell cycle arrest in colon cancer cell lines. PMID: 11481417 |
Ref: Antitumor effects of miconazole on human colon carcinoma xenografts in nude mice through induction of apoptosis and G0/G1 cell cycle arrest. PMID: 11922774 Ref: Monoterpenes inhibit proliferation of human colon cancer cells by modulating cell cycle-related protein expression. PMID: 12175534 Ref: SU9516, a cyclin-dependent kinase 2 inhibitor, promotes accumulation of high molecular weight E2F complexes in human colon carcinoma cells. PMID: 12234612 Ref: Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells. PMID: 12376477 Ref: Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 2. Probing the indeno ring substituent pattern. PMID: 12431050 Ref: Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest. PMID: 12460790 |
Ref: Proliferation of cancer cells despite CDK2 inhibition. PMID: 12676582 Ref: [Stat3 signal transduction pathway orchestrates G1 to S cell cycle transition in colon cancer cells]. PMID: 12920809 Ref: p21-dependent inhibition of colon cancer cell growth by mevastatin is independent of inhibition of G1 cyclin-dependent kinases. PMID: 12930830 Ref: Expressing patterns of p16 and CDK4 correlated to prognosis in colorectal carcinoma. PMID: 14562378 Ref: Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells. PMID: 14614451 |
Ref: The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway. PMID: 14729633 Ref: Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1. PMID: 15172998 Ref: Synthetic bile acid derivatives inhibit cell proliferation and induce apoptosis in HT-29 human colon cancer cells. PMID: 15202011 Ref: Identification of 4-anilino-3-quinolinecarbonitrile inhibitors of mitogen-activated protein/extracellular signal-regulated kinase 1 kinase. PMID: 15210862 Ref: Autocrine and exogenous transforming growth factor beta control cell cycle inhibition through pathways with different sensitivity. PMID: 15271980 Ref: Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1). PMID: 15317660 Ref: Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. PMID: 15526363 Ref: Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. PMID: 15542782 Ref: Tetrandrine induces early G1 arrest in human colon carcinoma cells by down-regulating the activity and inducing the degradation of G1-S-specific cyclin-dependent kinases and by inducing p53 and p21Cip1. PMID: 15604277 Ref: [Effects of celecoxib on the proliferation and apoptosis of human colorectal cancer cell line HT-29]. PMID: 16136956 |
Ref: Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. PMID: 15309432 Ref: Tumor necrosis factor alpha-dependent drug resistance to purine and pyrimidine analogues in human colon tumor cells mediated through IKK. PMID: 15611081 Ref: Effect of indomethacin on cell cycle proteins in colon cancer cell lines. PMID: 15786552 Ref: Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models. PMID: 15841378 Ref: Inhibition of colon cancer cell proliferation by the dietary compound conjugated linoleic acid is mediated by the CDK inhibitor p21CIP1/WAF1. PMID: 15880444 Ref: Molecular mechanisms of econazole-induced toxicity on human colon cancer cells: G0/G1 cell cycle arrest and caspase 8-independent apoptotic signaling pathways. PMID: 15919146 Ref: Smad7 induces tumorigenicity by blocking TGF-beta-induced growth inhibition and apoptosis. PMID: 15922743 Ref: Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. PMID: 16082211 Ref: Escherichia coli verotoxin 1 mediates apoptosis in human HCT116 colon cancer cells by inducing overexpression of the GADD family of genes and S phase arrest. PMID: 16297916 Ref: Fisetin inhibits the activities of cyclin-dependent kinases leading to cell cycle arrest in HT-29 human colon cancer cells. PMID: 16317137 Ref: Correlation between the expressions of gastrin, somatostatin and cyclin and cyclin-depend kinase in colorectal cancer. PMID: 16437675 |
Ref: Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations. PMID: 16108056 Ref: Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators. PMID: 16434969 Ref: Trans-10,cis-12, not cis-9,trans-11, conjugated linoleic acid inhibits G1-S progression in HT-29 human colon cancer cells. PMID: 16549447 Ref: Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway. PMID: 16574813 Ref: [Antisense to CDK4 inhibits the growth of human colon cancer cells HT29]. PMID: 16681978 Ref: Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity. PMID: 17064073 Ref: Aberrant cytological localization of p16 and CDK4 in colorectal epithelia in the normal adenoma carcinoma sequence. PMID: 17072968 |
Ref: Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin. PMID: 16901994 Ref: Induction of apoptosis and cell-cycle arrest in human colon cancer cells by meclizine. PMID: 17222494 Ref: p38-mediated inactivation of cyclin D1/cyclin-dependent kinase 4 stimulates nucleolar translocation of RelA and apoptosis in colorectal cancer cells. PMID: 17308107 Ref: Gene profile analysis of colorectal cancer cell lines by cDNA macroarray. PMID: 17390045 Ref: p21(Waf1/Cip1/Sdi1) mediates retinoblastoma protein degradation. PMID: 17486059 Ref: CDK4 inhibitors and apoptosis: a novel mechanism requiring nucleolar targeting of RelA. PMID: 17525529 Ref: Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases. PMID: 17804748 |
Ref: Growth inhibition of human hepatic carcinoma HepG2 cells by fucoxanthin is associated with down-regulation of cyclin D. PMID: 18230364 Ref: Mucronulatol from Caribbean propolis exerts cytotoxic effects on human tumor cell lines. PMID: 18538108 Ref: Role of human aquaporin 5 in colorectal carcinogenesis. PMID: 18583321 Ref: Inhibition of cell-cycle progression in human colorectal carcinoma Lovo cells by andrographolide. PMID: 18619950 Ref: Benzylidene derivatives of andrographolide inhibit growth of breast and colon cancer cells in vitro by inducing G(1) arrest and apoptosis. PMID: 18806812 |
Ref: Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors. PMID: 18931700 Ref: Cell kinetics and gene expression changes in colorectal cancer patients given resistant starch: a randomised controlled trial. PMID: 18978177 Ref: TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway. PMID: 19208363 Ref: Curcumin synergizes the growth inhibitory properties of Indian toad (Bufo melanostictus Schneider) skin-derived factor (BM-ANF1) in HCT-116 colon cancer cells. PMID: 19331178 Ref: Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cells. PMID: 19480695 Ref: Smad2 and Smad3 phosphorylated at both linker and COOH-terminal regions transmit malignant TGF-beta signal in later stages of human colorectal cancer. PMID: 19531654 Ref: Mirk regulates the exit of colon cancer cells from quiescence. PMID: 19542220 Ref: Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression. PMID: 19561401 Ref: Depletion of PI3K p85alpha induces cell cycle arrest and apoptosis in colorectal cancer cells. PMID: 19885597 Ref: Xanthorrhizol, a natural sesquiterpenoid, induces apoptosis and growth arrest in HCT116 human colon cancer cells. PMID: 19926935 |
Ref: Differential antineoplastic effects of butyrate in cells with and without a functioning DNA mismatch repair. PMID: 20043265 Ref: Inhibition of aldose reductase prevents growth factor-induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in human colon cancer cells. PMID: 20354121 Ref: Gankyrin promotes the proliferation of human pancreatic cancer. PMID: 20483533 Ref: Suppression of NF-kappaB and GSK-3beta is involved in colon cancer cell growth inhibition by the PPAR agonist troglitazone. PMID: 20540935 Ref: Relation between normal rectal methylation, smoking status, and the presence or absence of colorectal adenomas. PMID: 20572039 Ref: Increased angiogenesis in Cdk4(R24C/R24C):Apc(+/Min) intestinal tumors. PMID: 20603602 Ref: Inhibition of cell growth and potentiation of tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis by a phenanthroindolizidine alkaloid antofine in human colon cancer cells. PMID: 20674553 Ref: Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss. PMID: 20736363 Ref: IGFBP-rP1, a potential molecule associated with colon cancer differentiation. PMID: 20977730 Ref: miRNA-145 inhibits non-small cell lung cancer cell proliferation by targeting c-Myc. PMID: 21092188 |
Ref: G-protein-coupled receptor for short-chain fatty acids suppresses colon cancer. PMID: 20979106 Ref: Functional interaction of Ugene and EBV infection mediates tumorigenic effects. PMID: 21317926 Ref: Cytotoxic and antineoplastic activity of timosaponin A-III for human colon cancer cells. PMID: 21370894 Ref: LYG-202 inhibits the proliferation of human colorectal carcinoma HCT-116 cells through induction of G1/S cell cycle arrest and apoptosis via p53 and p21(WAF1/Cip1) expression. PMID: 21491996 Ref: Antitumor effects of a novel benzonaphthofurandione derivative (8e) on the human colon cancer cells in vitro and in vivo through cell cycle arrest accompanied with the modulation of EGFR and mTOR signaling. PMID: 21600193 Ref: Acetylbritannilactone suppresses growth via upregulation of kruppel-like transcription factor 4 expression in HT-29 colorectal cancer cells. PMID: 21811764 Ref: Valproate inhibits colon cancer growth through cell cycle modification in vivo and in vitro. PMID: 22977502 |
Ref: 4-O-methylhonokiol inhibits colon tumor growth via p21-mediated suppression of NF-kappaB activity. PMID: 21820300 Ref: Role of p21 as a determinant of 1,6-Bis[4-(4-amino-3-hydroxyphenoxy)phenyl] diamantane response in human HCT-116 colon carcinoma cells. PMID: 22076474 Ref: Stat6 activity-related Th2 cytokine profile and tumor growth advantage of human colorectal cancer cells in vitro and in vivo. PMID: 22108090 Ref: Pien Tze Huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model. PMID: 22218594 Ref: PAK1-dependent MAPK pathway activation is required for colorectal cancer cell proliferation. PMID: 22252525 Ref: The chemopreventive agent ursodeoxycholic acid inhibits proliferation of colon carcinoma cells by suppressing c-Myc expression. PMID: 22395148 Ref: Loss of desmocollin 1-3 and homeobox genes PITX1 and CDX2 are associated with tumor progression and survival in colorectal carcinoma. PMID: 22438068 Ref: Triptolide inhibits colon-rectal cancer cells proliferation by induction of G1 phase arrest through upregulation of p21. PMID: 22464014 Ref: Triplex DNA-binding proteins are associated with clinical outcomes revealed by proteomic measurements in patients with colorectal cancer. PMID: 22682314 Ref: Methyl nomilinate from citrus can modulate cell cycle regulators to induce cytotoxicity in human colon cancer (SW480) cells in vitro. PMID: 22728232 Ref: Hedyotis diffusa Willd inhibits colorectal cancer growth in vivo via inhibition of STAT3 signaling pathway. PMID: 22754353 Ref: Novel germline CDK4 mutations in patients with head and neck cancer. PMID: 22932448 Ref: Co-crystalization and in vitro biological characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors. PMID: 22984537 Ref: MSP58 knockdown inhibits the proliferation of esophageal squamous cell carcinoma in vitro and in vivo. PMID: 22994740 Ref: Inactivation of the Dlc1 gene cooperates with downregulation of p15INK4b and p16Ink4a, leading to neoplastic transformation and poor prognosis in human cancer. PMID: 23010077 Ref: Hedyotis diffusa Willd extract inhibits HT-29 cell proliferation via cell cycle arrest. PMID: 23139718 Ref: Pien Tze Huang inhibits the proliferation of human colon carcinoma cells by arresting G1/S cell cycle progression. PMID: 23205099 |
Ref: Cladosporol a stimulates G1-phase arrest of the cell cycle by up-regulation of p21(waf1/cip1) expression in human colon carcinoma HT-29 cells. PMID: 22025467 Ref: Identification of novel driver tumor suppressors through functional interrogation of putative passenger mutations in colorectal cancer. PMID: 22753261 Ref: Suppression of Src/ERK and GSK-3/beta-catenin signaling by pinosylvin inhibits the growth of human colorectal cancer cells. PMID: 23333577 Ref: Scutellaria barbata D. Don induces G1/S arrest via modulation of p53 and Akt pathways in human colon carcinoma cells. PMID: 23354912 Ref: Boletus edulis biologically active biopolymers induce cell cycle arrest in human colon adenocarcinoma cells. PMID: 23370594 Ref: Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions. PMID: 23434653 Ref: Chemoprevention utility of silibinin and Cdk4 pathway inhibition in Apc(-/+) mice. PMID: 23530816 Ref: Small interfering RNA targeting Rac1 sensitizes colon cancer to dihydroartemisinin-induced cell cycle arrest and inhibited cell migration by suppressing NFkappaB activity. PMID: 23559092 Ref: Patchouli alcohol, an essential oil of Pogostemon cablin, exhibits anti-tumorigenic activity in human colorectal cancer cells. PMID: 23602914 Ref: Spica prunellae promotes cancer cell apoptosis, inhibits cell proliferation and tumor angiogenesis in a mouse model of colorectal cancer via suppression of stat3 pathway. PMID: 23800091 Ref: Plant-derived mAbs have effective anti-cancer activities by increasing ganglioside expression in colon cancers. PMID: 24078119 Ref: Gastrin promotes intestinal polyposis through cholecystokinin-B receptor-mediated proliferative signaling and fostering tumor microenvironment. PMID: 24101389 Ref: Spica Prunellae extract inhibits the proliferation of human colon carcinoma cells via the regulation of the cell cycle. PMID: 24137475 Ref: Kaempferol Induces Cell Cycle Arrest in HT-29 Human Colon Cancer Cells. PMID: 25337553 |
Ref: Reg4-induced mitogenesis involves Akt-GSK3beta-beta-Catenin-TCF-4 signaling in human colorectal cancer. PMID: 24151146 Ref: Scutellaria Barbata D Don Inhibits Colorectal Cancer Growth via Suppression of Multiple Signaling Pathways. PMID: 24231788 Ref: PD-0332991 induces G1 arrest of colorectal carcinoma cells through inhibition of the cyclin-dependent kinase-6 and retinoblastoma protein axis. PMID: 24765199 Ref: Anti-proliferative and pro-apoptotic activity of whole extract and isolated indicaxanthin from Opuntia ficus-indica associated with re-activation of the onco-suppressor p16(INK4a) gene in human colorectal carcinoma (Caco-2) cells. PMID: 24937448 Ref: Anti cancer effects of Cnidium officinale Makino extract mediated through apoptosis and cell cycle arrest in the HT-29 human colorectal cancer cell line. PMID: 25040960 Ref: Resveratrol inhibits proliferation in human colorectal carcinoma cells by inducing G1/Sphase cell cycle arrest and apoptosis through caspase/cyclinCDK pathways. PMID: 25050564 Ref: Involvement of ERK1/2, p38 MAPK, and PI3K/Akt signaling pathways in the regulation of cell cycle progression by PTHrP in colon adenocarcinoma cells. PMID: 25051885 Ref: Essential oil of Pinus koraiensis inhibits cell proliferation and migration via inhibition of p21-activated kinase 1 pathway in HCT116 colorectal cancer cells. PMID: 25074784 Ref: Mutant NRASQ61 shares signaling similarities across various cancer types--potential implications for future therapies. PMID: 25277205 Ref: Celecoxib prevents colitis associated colon carcinogenesis: an upregulation of apoptosis. PMID: 25443739 |
Ref: Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins. PMID: 24292678 Ref: Bile acids regulate nuclear receptor (Nur77) expression and intracellular location to control proliferation and apoptosis. PMID: 25232032 Ref: Patrinia scabiosaefolia inhibits the proliferation of colorectal cancer in vitro and in vivo via G1/S cell cycle arrest. PMID: 25500894 Ref: Myeloid cell leukemia-1 is associated with tumor progression by inhibiting apoptosis and enhancing angiogenesis in colorectal cancer. PMID: 25628923 Ref: Analysis of BAP1 Germline Gene Mutation in Young Uveal Melanoma Patients. PMID: 25687217 Ref: Cyclin-dependent kinase pathway aberrations in diverse malignancies: clinical and molecular characteristics. PMID: 25695927 Ref: Downregulation of telomerase activity by diclofenac and curcumin is associated with cell cycle arrest and induction of apoptosis in colon cancer. PMID: 25744732 Ref: Cell cycle regulation and apoptotic cell death in experimental colon carcinogenesis: intervening with cyclooxygenase-2 inhibitors. PMID: 25825916 Ref: Ethanol extract of Innotus obliquus (Chaga mushroom) induces G1 cell cycle arrest in HT-29 human colon cancer cells. PMID: 25861415 Ref: Role of SMC1A overexpression as a predictor of poor prognosis in late stage colorectal cancer. PMID: 25884313 Ref: [Mechanism of thioridazine-induced apoptosis of human colorectal cancer SW480 cells]. PMID: 25907934 Ref: Smad2/3 linker phosphorylation is a possible marker of cancer stem cells and correlates with carcinogenesis in a mouse model of colitis-associated colorectal cancer. PMID: 25908723 Ref: Exome Sequencing of Normal and Isogenic Transformed Human Colonic Epithelial Cells (HCECs) Reveals Novel Genes Potentially Involved in the Early Stages of Colorectal Tumorigenesis. PMID: 25923178 Ref: Targeting of multiple oncogenic signaling pathways by Hsp90 inhibitor alone or in combination with berberine for treatment of colorectal cancer. PMID: 25982393 Ref: Growth inhibitory and chemo-sensitization effects of naringenin, a natural flavanone purified from Thymus vulgaris, on human breast and colorectal cancer. PMID: 26074733 Ref: Jianpi Huayu Decoction Inhibits Proliferation in Human Colorectal Cancer Cells (SW480) by Inducing G0/G1-Phase Cell Cycle Arrest and Apoptosis. PMID: 26457107 Ref: Syntenin controls migration, growth, proliferation, and cell cycle progression in cancer cells. PMID: 26539120 Ref: A-kinase anchor protein 4 (AKAP4) a promising therapeutic target of colorectal cancer. PMID: 26590805 Ref: Anticolorectal cancer effects and pharmacokinetic application of 2, 2-Bis [4-(4-amino-3-hydroxyphenoxy) phenyl] adamantane. PMID: 26628962 |
Ref: Sensitivity of KRAS-Mutant Colorectal Cancers to Combination Therapy That Cotargets MEK and CDK4/6. PMID: 26369631 Ref: Knockdown of linc-POU3F3 suppresses the proliferation, apoptosis, and migration resistance of colorectal cancer. PMID: 26510906 Ref: Dual inhibition of COX-2/5-LOX blocks colon cancer proliferation, migration and invasion in vitro. PMID: 26707712 Ref: Pristimerin demonstrates anticancer potential in colorectal cancer cells by inducing G1 phase arrest and apoptosis and suppressing various pro-survival signaling proteins. PMID: 26718323 Ref: Chidamide and 5-flurouracil show a synergistic antitumor effect on human colon cancer xenografts in nude mice. PMID: 26774139 Ref: Anti-tumor role of Bacillus subtilis fmbJ-derived fengycin on human colon cancer HT29 cell line. PMID: 26774143 Ref: Phosphorylated retinoblastoma protein is a potential predictive marker of irinotecan efficacy for colorectal cancer. PMID: 26783196 Ref: Flavokawain C Inhibits Cell Cycle and Promotes Apoptosis, Associated with Endoplasmic Reticulum Stress and Regulation of MAPKs and Akt Signaling Pathways in HCT 116 Human Colon Carcinoma Cells. PMID: 26859847 Ref: The AhR is involved in the regulation of LoVo cell proliferation through cell cycle-associated proteins. PMID: 26861731 Ref: SRJ09, a promising anticancer drug lead: Elucidation of mechanisms of antiproliferative and apoptogenic effects and assessment of in vivo antitumor efficacy. PMID: 26940565 Ref: Deoxyelephantopin from Elephantopus scaber Inhibits HCT116 Human Colorectal Carcinoma Cell Growth through Apoptosis and Cell Cycle Arrest. PMID: 27007366 Ref: Efficacy of the combination of MEK and CDK4/6 inhibitors in vitro and in vivo in KRAS mutant colorectal cancer models. PMID: 27167191 Ref: microRNA-374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway. PMID: 27191497 Ref: Knockdown of linc-UFC1 suppresses proliferation and induces apoptosis of colorectal cancer. PMID: 27195675 Ref: Efficacy and Safety of Abemaciclib, an Inhibitor of CDK4 and CDK6, for Patients with Breast Cancer, Non-Small Cell Lung Cancer, and Other Solid Tumors. PMID: 27217383 Ref: An Association Map on the Effect of Flavonoids on the Signaling Pathways in Colorectal Cancer. PMID: 27226778 Ref: CDK4/6 Inhibitors: Promising Opportunities beyond Breast Cancer. PMID: 27371575 Ref: Downregulation of CREB Promotes Cell Proliferation by Mediating G1/S Phase Transition in Hodgkin Lymphoma. PMID: 27458098 Ref: Secoisolariciresinol diglucoside rich extract of L. usitatissimum prevents diabetic colon cancer through inhibition of CDK4. PMID: 27470575 Ref: Anti-cancer activity of Psoralea fructus through the downregulation of cyclin D1 and CDK4 in human colorectal cancer cells. PMID: 27670681 Ref: Stereoisomers of Astaxanthin Inhibit Human Colon Cancer Cell Growth by Inducing G2/M Cell Cycle Arrest and Apoptosis. PMID: 27726394 Ref: High expression of CREPT promotes tumor growth and is correlated with poor prognosis in colorectal cancer. PMID: 27773816 Ref: c-Myc is regulated by HIF-2alpha in chronic hypoxia and influences sensitivity to 5-FU in colon cancer. PMID: 27793037 |
Ref: Lebein, a snake venom disintegrin, suppresses human colon cancer cells proliferation and tumor-induced angiogenesis through cell cycle arrest, apoptosis induction and inhibition of VEGF expression. PMID: 26824338 Ref: pathTiMEx: Joint Inference of Mutually Exclusive Cancer Pathways and Their Progression Dynamics. PMID: 27936934 Ref: Identification of terpenoids from Rubus corchorifolius L. f. leaves and their anti-proliferative effects on human cancer cells. PMID: 28134947 Ref: Novel ent-Kaurane Diterpenoid from Rubus corchorifolius L. f. Inhibits Human Colon Cancer Cell Growth via Inducing Cell Cycle Arrest and Apoptosis. PMID: 28169543 Ref: LncRNA SNHG12 promotes cell growth and inhibits cell apoptosis in colorectal cancer cells. PMID: 28225893 Ref: Cell-Cycle Regulation Accounts for Variability in Ki-67 Expression Levels. PMID: 28283655 Ref: The CDK4/6 inhibitor palbociclib synergizes with irinotecan to promote colorectal cancer cell death under hypoxia. PMID: 28486050 Ref: Induction of p53-Independent Apoptosis and G1 Cell Cycle Arrest by Fucoidan in HCT116 Human Colorectal Carcinoma Cells. PMID: 28555064 Ref: Synthetic lethal interaction of CDK inhibition and autophagy inhibition in human solid cancer cell lines. PMID: 28560460 Ref: ICT1 predicts a poor survival and correlated with cell proliferation in diffuse large B-cell lymphoma. PMID: 28629825 Ref: Ursodeoxycholic acid inhibits the proliferation of colon cancer cells by regulating oxidative stress and cancer stem-like cell growth. PMID: 28708871 Ref: Mertensene, a Halogenated Monoterpene, Induces G2/M Cell Cycle Arrest and Caspase Dependent Apoptosis of Human Colon Adenocarcinoma HT29 Cell Line through the Modulation of ERK-1/-2, AKT and NF-kappaB Signaling. PMID: 28726723 Ref: Synergistic antitumor effect of 3-bromopyruvate and 5-fluorouracil against human colorectal cancer through cell cycle arrest and induction of apoptosis. PMID: 28816773 Ref: Inhibition of cell cycle progression by the hydroxytyrosol-cetuximab combination yields enhanced chemotherapeutic efficacy in colon cancer cells. PMID: 29137335 Ref: [Effects of LncRNA H19 on Proliferation of Human Colorectal Cancer SW620 Cells]. PMID: 29260518 |
Ref: Curcumol induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3beta/cyclin D1 pathway. PMID: 28684297 Ref: Cellular Prion Protein Enhances Drug Resistance of Colorectal Cancer Cells via Regulation of a Survival Signal Pathway. PMID: 28822989 Ref: Simvastatin induces G1 arrest by up-regulating GSK3beta and down-regulating CDK4/cyclin D1 and CDK2/cyclin E1 in human primary colorectal cancer cells. PMID: 28833099 Ref: Hedyotis diffusa Willd inhibits proliferation and induces apoptosis of 5FU resistant colorectal cancer cells by regulating the PI3K/AKT signaling pathway. PMID: 29115462 Ref: mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis. PMID: 29275959 Ref: Cdc37 facilitates cell survival of colorectal carcinoma via activating the CDK4 signaling pathway. PMID: 29288563 Ref: Vitex rotundifolia Fruit Suppresses the Proliferation of Human Colorectal Cancer Cells through Down-regulation of Cyclin D1 and CDK4 via Proteasomal-Dependent Degradation and Transcriptional Inhibition. PMID: 29298515 Ref: Oncogene RPA1 promotes proliferation of hepatocellular carcinoma via CDK4/Cyclin-D pathway. PMID: 29477843 Ref: Anticancer evaluation and molecular modeling of multi-targeted kinase inhibitors based pyrido[2,3-d]pyrimidine scaffold. PMID: 29482389 Ref: Coroglaucigenin induces senescence and autophagy in colorectal cancer cells. PMID: 29484762 Ref: Expression of factors and key components associated with the PI3K signaling pathway in colon cancer. PMID: 29552187 Ref: The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. Part 1: the suppression of cell proliferation, promotion of apoptosis and arrest of the cell cycle. PMID: 29645049 Ref: Astragaloside IV inhibits cell proliferation of colorectal cancer cell lines through down-regulation of B7-H3. PMID: 29710520 Ref: [Role of allograft inflammatory factor-1 in regulating the proliferation, migration and apoptosis of colorectal cancer cells]. PMID: 29891445 Ref: Triggering of cancer cell cycle arrest by a novel scorpion venom-derived peptide-Gonearrestide. PMID: 29993185 Ref: Anti-inflammation and Anti-Cancer Activity of Ethanol Extract of Antarctic Freshwater Microalga, Micractinium sp. PMID: 30008606 Ref: Total ginsenosides of Chinese ginseng induces cell cycle arrest and apoptosis in colorectal carcinoma HT-29 cells. PMID: 30197678 Ref: Gomisin A Suppresses Colorectal Lung Metastasis by Inducing AMPK/p38-Mediated Apoptosis and Decreasing Metastatic Abilities of Colorectal Cancer Cells. PMID: 30210348 Ref: Evaluation of the effect of 2-(2,4-dihydroxyphenyl)-4H-benzofuro[3,2-d][1,3]thiazin-4-one on colon cells and its anticancer potential. PMID: 30220832 Ref: Baicalein Inhibits Proliferation Activity of Human Colorectal Cancer Cells HCT116 Through Downregulation of Ezrin. PMID: 30244250 Ref: PTBP1 promotes tumorigenesis by regulating apoptosis and cell cycle in colon cancer. PMID: 30309622 Ref: An Intrinsic Mitochondrial Pathway Is Required for Phytic Acid-Chitosan-Iron Oxide Nanocomposite (Phy-CS-MNP) to Induce G(0)/G(1) Cell Cycle Arrest and Apoptosis in the Human Colorectal Cancer (HT-29) Cell Line. PMID: 30360519 |