Primary Site >> Colorectal Cancer

Gene >> CDK2

1.
Journal: Jpn J Cancer Res. 1995 Sep;86(9):819-27.
Title: Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism.
Author: Ohashi, M|Sugikawa, E|Nakanishi, N
PMID: 7591958
2.
Journal: Int J Cancer. 1995 Jul 4;62(1):25-8.
Title: Concurrent amplification of cyclin E and CDK2 genes in colorectal carcinomas.
Author: Kitahara, K|Yasui, W|Kuniyasu, H|Yokozaki, H|Akama, Y|Yunotani, S|Hisatsugu, T|Tahara, E
PMID: 7601562
3.
Journal: Br J Cancer. 1995 Jun;71(6):1231-6.
Title: Coexpression of cdk2/cdc2 and retinoblastoma gene products in colorectal cancer.
Author: Yamamoto, H|Monden, T|Ikeda, K|Izawa, H|Fukuda, K|Fukunaga, M|Tomita, N|Shimano, T|Shiozaki, H|Monden, M
PMID: 7779716
4.
Journal: Nihon Rinsho. 1996 Apr;54(4):965-71.
Title: [RB gene expression in gastrointestinal tract].
Author: Monden, T|Yamamoto, H|Ikeda, K|Izawa, H|Tsujie, M|Ohnishi, T|Miyoshi, Y|Sekimoto, M|Tomita, N|Monden, M
PMID: 8920658
5.
Journal: Clin Cancer Res. 1996 Jul;2(7):1221-9.
Title: Suppression of cancer cell growth by adenovirus expressing p21(WAF1/CIP1) deficient in PCNA interaction.
Author: Prabhu, N S|Blagosklonny, M V|Zeng, Y X|Wu, G S|Waldman, T|El-Deiry, W S
PMID: 9816291
6.
Journal: J Biol Chem. 1998 Jan 16;273(3):1662-9.
Title: Disruption of fibronectin binding to the alpha 5 beta 1 integrin stimulates the expression of cyclin-dependent kinases and DNA synthesis through activation of extracellular signal-regulated kinase.
Author: Gong, J|Ko, T C|Brattain, M G
PMID: 9430710
7.
Journal: Oncogene. 1998 Feb 12;16(6):705-12.
Title: Mutated p21(WAF1/CIP1/SDI1) lacking CDK-inhibitory activity fails to prevent apoptosis in human colorectal carcinoma cells.
Author: Lu, Y|Yamagishi, N|Yagi, T|Takebe, H
PMID: 9488034
8.
Journal: Int J Oncol. 1998 Aug;13(2):233-9.
Title: Cdk2/cdc2 expression in colon carcinogenesis and effects of cdk2/cdc2 inhibitor in colon cancer cells.
Author: Yamamoto, H|Monden, T|Miyoshi, H|Izawa, H|Ikeda, K|Tsujie, M|Ohnishi, T|Sekimoto, M|Tomita, N|Monden, M
PMID: 9664116
9.
Journal: Am J Physiol. 1998 Nov;275(5 Pt 1):C1193-200.
Title: Caco-2 intestinal cell differentiation is associated with G1 arrest and suppression of CDK2 and CDK4.
Author: Ding, Q M|Ko, T C|Evers, B M
PMID: 9814966
10.
Journal: Oncogene. 1999 Jan 7;18(1):103-15.
Title: Comparative effects of overexpression of p27Kip1 and p21Cip1/Waf1 on growth and differentiation in human colon carcinoma cells.
Author: Yamamoto, H|Soh, J W|Shirin, H|Xing, W Q|Lim, J T|Yao, Y|Slosberg, E|Tomita, N|Schieren, I|Weinstein, I B
PMID: 9926925
11.
Journal: Ann Surg Oncol. 1999 Jan-Feb;6(1):19-25.
Title: Absence of the cell cycle inhibitor p27Kip1 protein predicts poor outcome in patients with stage I-III colorectal cancer.
Author: Belluco, C|Esposito, G|Bertorelle, R|Del Mistro, A|Fassina, A|Vieceli, G|Chieco-Bianchi, L|Nitti, D|Lise, M
PMID: 10030411
12.
Journal: Cancer. 1999 Feb 1;85(3):546-53.
Title: Amplified CDK2 and cdc2 activities in primary colorectal carcinoma.
Author: Kim, J H|Kang, M J|Park, C U|Kwak, H J|Hwang, Y|Koh, G Y
PMID: 10091728
13.
Journal: Nature. 1999 Apr 1;398(6726):422-6.
Title: Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.
Author: Tetsu, O|McCormick, F
PMID: 10201372
14.
Journal: Mol Cell Biol. 1999 May;19(5):3916-28.
Title: Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a).
Author: Mitra, J|Dai, C Y|Somasundaram, K|El-Deiry, W S|Satyamoorthy, K|Herlyn, M|Enders, G H
PMID: 10207115
15.
Journal: Anticancer Res. 1999 Jan-Feb;19(1B):741-8.
Title: Differential cyclin-dependent kinase expression and activation in human colon cancer.
Author: Salh, B|Bergman, D|Marotta, A|Pelech, S L
PMID: 10216486
16.
Journal: Exp Cell Res. 1999 Jun 15;249(2):240-7.
Title: NA22598, a novel antitumor compound, reduces cyclin D1 levels, arrests cell cycle at G1 phase, and inhibits anchorage-independent growth of human tumor cells.
Author: Kawada, M|Kuwahara, A|Nishikiori, T|Mizuno, S|Uehara, Y
PMID: 10366423
17.
Journal: Jpn J Cancer Res. 1999 Dec;90(12):1364-72.
Title: G1-checkpoint function including a cyclin-dependent kinase 2 regulatory pathway as potential determinant of 7-hydroxystaurosporine (UCN-01)-induced apoptosis and G1-phase accumulation.
Author: Akiyama, T|Sugiyama, K|Shimizu, M|Tamaoki, T|Akinaga, S
PMID: 10665655
18.
Journal: Curr Pharm Des. 2000 Mar;6(4):379-92.
Title: Cell cycle molecular targets in novel anticancer drug discovery.
Author: Buolamwini, J K
PMID: 10788588
19.
Journal: Clin Cancer Res. 2000 Jul;6(7):2951-8.
Title: Changes in E2F binding after phenylbutyrate-induced differentiation of Caco-2 colon cancer cells.
Author: Wang, Q M|Feinman, R|Kashanchi, F|Houghton, J M|Studzinski, G P|Harrison, L E
PMID: 10914745
20.
Journal: Mol Cell Biol Res Commun. 2000 Jun;3(6):352-9.
Title: Downregulation of cyclin D1 alters cdk 4- and cdk 2-specific phosphorylation of retinoblastoma protein.
Author: Yu, B|Lane, M E|Pestell, R G|Albanese, C|Wadler, S
PMID: 11032757
21.
Journal: Cancer Chemother Pharmacol. 2000;46(4):293-304.
Title: Expression of pRB, cyclin/cyclin-dependent kinases and E2F1/DP-1 in human tumor lines in cell culture and in xenograft tissues and response to cell cycle agents.
Author: Lu, K|Shih, C|Teicher, B A
PMID: 11052627
22.
Journal: Endocrinology. 2000 Nov;141(11):3931-9.
Title: A vitamin D3 analog induces a G1-phase arrest in CaCo-2 cells by inhibiting cdk2 and cdk6: roles of cyclin E, p21Waf1, and p27Kip1.
Author: Scaglione-Sewell, B A|Bissonnette, M|Skarosi, S|Abraham, C|Brasitus, T A
PMID: 11089522
23.
Journal: J Antibiot (Tokyo). 2000 Oct;53(10):1191-200.
Title: Mechanism of cell cycle arrest caused by histone deacetylase inhibitors in human carcinoma cells.
Author: Kim, Y B|Ki, S W|Yoshida, M|Horinouchi, S
PMID: 11132966
24.
Journal: J Radiat Res. 2000 Dec;41(4):341-8.
Title: Inhibition of X-ray and doxorubicin-induced apoptosis by butyrolactone I, a CDK-specific inhibitor, in human tumor cells.
Author: Lu, Y|Takebe, H|Yagi, T
PMID: 11329882
25.
Journal: Int J Oncol. 2001 May;18(5):997-1002.
Title: Synergistic effects of dexamethasone and genistein on the expression of Cdk inhibitor p21WAF1/CIP1 in human hepatocellular and colorectal carcinoma cells.
Author: Park, J H|Oh, E J|Choi, Y H|Kang, C D|Kang, H S|Kim, D K|Kang, K I|Yoo, M A
PMID: 11295047
26.
Journal: Anticancer Res. 2001 Jan-Feb;21(1A):137-43.
Title: Upregulated expression of angiogenesis genes and down regulation of cell cycle genes in human colorectal cancer tissue determined by cDNA macroarray.
Author: Tsunoda, T|Nakamura, T|Ishimoto, K|Yamaue, H|Tanimura, H|Saijo, N|Nishio, K
PMID: 11299727
27.
Journal: Anticancer Res. 2001 Mar-Apr;21(2A):873-8.
Title: Curcumin induced modulation of cell cycle and apoptosis in gastric and colon cancer cells.
Author: Moragoda, L|Jaszewski, R|Majumdar, A P
PMID: 11396178
28.
Journal: Am J Physiol Gastrointest Liver Physiol. 2001 Jul;281(1):G37-43.
Title: Polyamine depletion arrests growth of IEC-6 and Caco-2 cells by different mechanisms.
Author: Ray, R M|McCormack, S A|Johnson, L R
PMID: 11408253
29.
Journal: Carcinogenesis. 2001 Jul;22(7):1061-7.
Title: HMG-CoA reductase inhibitor mevastatin enhances the growth inhibitory effect of butyrate in the colorectal carcinoma cell line Caco-2.
Author: Wachtershauser, A|Akoglu, B|Stein, J
PMID: 11408350
30.
Journal: J Nutr. 2001 Aug;131(8):2197-203.
Title: Downregulation of the cyclin D1/Cdk4 complex occurs during resveratrol-induced cell cycle arrest in colon cancer cell lines.
Author: Wolter, F|Akoglu, B|Clausnitzer, A|Stein, J
PMID: 11481417
31.
Journal: Cancer Lett. 2001 Sep 28;171(1):57-65.
Title: Tributyrin, an oral butyrate analogue, induces apoptosis through the activation of caspase-3.
Author: Clarke, K O|Feinman, R|Harrison, L E
PMID: 11485828
32.
Journal: Int J Oncol. 2001 Sep;19(3):613-6.
Title: DNA alkylation-induced phosphorylation of p53 and activation of kinases in colon cancer cells.
Author: Jaiswal, A S|Narayan, S
PMID: 11494044
33.
Journal: Cancer Res. 2001 Aug 15;61(16):6170-7.
Title: A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cells.
Author: Lane, M E|Yu, B|Rice, A|Lipson, K E|Liang, C|Sun, L|Tang, C|McMahon, G|Pestell, R G|Wadler, S
PMID: 11507069
34.
Journal: J Virol. 2001 Oct;75(20):9844-56.
Title: Inactivation of p21 by E1A leads to the induction of apoptosis in DNA-damaged cells.
Author: Chattopadhyay, D|Ghosh, M K|Mal, A|Harter, M L
PMID: 11559818
35.
Journal: Curr Med Chem. 2001 Oct;8(12):1487-503.
Title: Cell cycle regulation in the G1 phase: a promising target for the development of new chemotherapeutic anticancer agents.
Author: Owa, T|Yoshino, H|Yoshimatsu, K|Nagasu, T
PMID: 11562278
36.
Journal: Hum Pathol. 2001 Sep;32(9):945-53.
Title: Expression of cyclin E and cyclin-dependent kinase 2 correlates with metastasis and prognosis in colorectal carcinoma.
Author: Li, J Q|Miki, H|Ohmori, M|Wu, F|Funamoto, Y
PMID: 11567224
37.
Journal: J Biol Chem. 2001 Nov 30;276(48):45201-6.
Title: The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax.
Author: Samuel, T|Weber, H O|Rauch, P|Verdoodt, B|Eppel, J T|McShea, A|Hermeking, H|Funk, J O
PMID: 11574543
38.
Journal: Dig Dis Sci. 2001 Oct;46(10):2187-98.
Title: Activation of cyclin E-dependent kinase activity in colorectal cancer.
Author: Cam, W R|Masaki, T|Shiratori, T Y|Kato, N|Okamoto, M|Yamaji, Y|Igarashi, K|Sano, T|Omata, M
PMID: 11680595
39.
Journal: Mol Pharmacol. 2001 Dec;60(6):1383-91.
Title: Induction of cyclin E and inhibition of DNA synthesis by the novel acronycine derivative S23906-1 precede the irreversible arrest of tumor cells in S phase leading to apoptosis.
Author: Leonce, S|Perez, V|Lambel, S|Peyroulan, D|Tillequin, F|Michel, S|Koch, M|Pfeiffer, B|Atassi, G|Hickman, J A|Pierre, A
PMID: 11723246
40.
Journal: J Biol Chem. 2002 Mar 22;277(12):9870-9. Epub 2002 Jan 9.
Title: Transforming growth factor beta 1 induces proliferation in colon carcinoma cells by Ras-dependent, smad-independent down-regulation of p21cip1.
Author: Yan, Zhongfa|Kim, Geum-Yi|Deng, Xiaobing|Friedman, Eileen
PMID: 11784716
41.
Journal: Int J Mol Med. 2002 Aug;10(2):193-9.
Title: Resveratrol, a chemopreventive agent, disrupts the cell cycle control of human SW480 colorectal tumor cells.
Author: Delmas, Delmas|Passilly-Degrace, Patricia|Jannin, Brigitte|Cherkaoui Malki, Mustapha|Latruffe, Norbert
PMID: 12119558
42.
Journal: Eur J Cancer Prev. 2002 Jun;11(3):271-81.
Title: Butyrate and aspirin in combination have an enhanced effect on apoptosis in human colorectal cancer cells.
Author: Menzel, T|Schauber, J|Kreth, F|Kudlich, T|Melcher, R|Gostner, A|Scheppach, W|Luhrs, H
PMID: 12131661
43.
Journal: Cancer Lett. 2002 Jul 26;181(2):187-94.
Title: Monoterpenes inhibit proliferation of human colon cancer cells by modulating cell cycle-related protein expression.
Author: Bardon, Sylvie|Foussard, Valerie|Fournel, Sophie|Loubat, Agnes
PMID: 12175534
44.
Journal: Eur J Cancer. 2002 Sep;38(14):1838-48.
Title: p107 Expression in colorectal tumours rises during carcinogenesis and falls during invasion.
Author: Wu, F|Li, J Q|Miki, H|Nishioka, M|Fujita, J|Ohmori, M|Imaida, K|Kuriyama, S
PMID: 12204665
45.
Journal: Biochem Pharmacol. 2002 Oct 1;64(7):1091-100.
Title: SU9516, a cyclin-dependent kinase 2 inhibitor, promotes accumulation of high molecular weight E2F complexes in human colon carcinoma cells.
Author: Yu, Bo|Lane, Maureen E|Wadler, Scott
PMID: 12234612
46.
Journal: Carcinogenesis. 2002 Oct;23(10):1677-84.
Title: Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells.
Author: Pan, Min-Hsiung|Chen, Wei-Jen|Lin-Shiau, Shoei-Yn|Ho, Chi-Tang|Lin, Jen-Kun
PMID: 12376477
47.
Journal: Biochem Biophys Res Commun. 2002 Oct 18;298(1):178-83.
Title: Hygrolidin induces p21 expression and abrogates cell cycle progression at G1 and S phases.
Author: Kawada, Manabu|Usami, Ihomi|Ohba, Shun|Someno, Tetsuya|Kim, Jin|Hayakawa, Yoichi|Nose, Kiyoshi|Ishizuka, Masaaki
PMID: 12379237
48.
Journal: Hum Pathol. 2002 Oct;33(10):1006-15.
Title: Cyclin A correlates with carcinogenesis and metastasis, and p27(kip1) correlates with lymphatic invasion, in colorectal neoplasms.
Author: Li, Jia-Qing|Miki, Hiroshi|Wu, Fei|Saoo, Kousuke|Nishioka, Mikio|Ohmori, Masaki|Imaida, Katsumi
PMID: 12395374
49.
Journal: J Med Chem. 2002 Nov 21;45(24):5224-32.
Title: Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 2. Probing the indeno ring substituent pattern.
Author: Nugiel, David A|Vidwans, Anup|Etzkorn, Anna-Marie|Rossi, Karen A|Benfield, Pamela A|Burton, Catherine R|Cox, Sarah|Doleniak, Deborah|Seitz, Steven P
PMID: 12431050
50.
Journal: Int J Cancer. 2002 Dec 10;102(5):463-8.
Title: In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine).
Author: McClue, Steven J|Blake, David|Clarke, Rosemary|Cowan, Angela|Cummings, Lorna|Fischer, Peter M|MacKenzie, Mairi|Melville, Jean|Stewart, Kevin|Wang, Shudong|Zhelev, Nikolai|Zheleva, Daniella|Lane, David P
PMID: 12432547
51.
Journal: Anticancer Drugs. 2002 Nov;13(10):989-97.
Title: E7070: a novel synthetic sulfonamide targeting the cell cycle progression for the treatment of cancer.
Author: Van Kesteren, Charlotte|Beijnen, Jos H|Schellens, Jan H M
PMID: 12439332
52.
Journal: Cancer Cell. 2003 Mar;3(3):233-45.
Title: Proliferation of cancer cells despite CDK2 inhibition.
Author: Tetsu, Osamu|McCormick, Frank
PMID: 12676582
53.
Journal: Cancer Res. 2003 Jun 15;63(12):3340-6.
Title: Transforming growth factor beta 1 increases the stability of p21/WAF1/CIP1 protein and inhibits CDK2 kinase activity in human colon carcinoma FET cells.
Author: Gong, JianGen|Ammanamanchi, Sudhakar|Ko, Tien C|Brattain, Michael G
PMID: 12810668
54.
Journal: Beijing Da Xue Xue Bao. 2003 Feb 18;35(1):50-3.
Title: [Stat3 signal transduction pathway orchestrates G1 to S cell cycle transition in colon cancer cells].
Author: Ma, Xiangtao|Wang, Shan|Du, Ruyu|Ye, Yingjiang|Wang, Shu|Yan, Feifei|Cui, Zhirong
PMID: 12920809
55.
Journal: J Biol Chem. 2003 Oct 31;278(44):43586-94. Epub 2003 Aug 19.
Title: p21-dependent inhibition of colon cancer cell growth by mevastatin is independent of inhibition of G1 cyclin-dependent kinases.
Author: Ukomadu, Chinweike|Dutta, Anindya
PMID: 12930830
56.
Journal: Oncogene. 2003 Nov 13;22(51):8271-82.
Title: Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells.
Author: Agarwal, Chapla|Singh, Rana P|Dhanalakshmi, Sivanandhan|Tyagi, Anil K|Tecklenburg, Marianne|Sclafani, Robert A|Agarwal, Rajesh
PMID: 14614451
57.
Journal: Nat Genet. 2003 Dec;35(4):323-30. Epub 2003 Nov 16.
Title: Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice.
Author: Aoki, Koji|Tamai, Yoshitaka|Horiike, Shigeo|Oshima, Masanobu|Taketo, Makoto M
PMID: 14625550
58.
Journal: Nutr Cancer. 2003;46(2):197-201.
Title: Cell cycle dysregulation induced by cytoplasm of Lactococcus lactis ssp lactis in SNUC2A, a colon cancer cell line.
Author: Kim, Ji Yeon|Woo, Hee Jong|Kim, Young-Suk|Kim, Kyoung Heon|Lee, Hyong Joo
PMID: 14690796
59.
Journal: Int J Colorectal Dis. 2004 Jan;19(1):12-7.
Title: Establishment of a colonic adenoma cell line (GEKI-2): spectral karyotype analysis and functional characterization.
Author: Menzel, Thomas|Melcher, Ralph|Koehler, Sigrid|Dusel, Gerda|Backhaus, Kerstin|Ott, German|Breithaupt, Wolfram|Al-Taie, Oliver|Schauber, Jurgen|Gostner, Andrea|Scheppach, Wolfgang|Luhrs, Hardi
PMID: 14648095
60.
Journal: Cancer Res. 2004 Jan 1;64(1):262-72.
Title: The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway.
Author: Whittaker, Steven R|Walton, Mike I|Garrett, Michelle D|Workman, Paul
PMID: 14729633
61.
Journal: Acta Pharmacol Sin. 2004 Jun;25(6):756-62.
Title: Abrogation of Chk1-mediated S/G2 checkpoint by UCN-01 enhances ara-C-induced cytotoxicity in human colon cancer cells.
Author: Shao, Rong-Guang|Cao, Chun-Xia|Pommier, Yves
PMID: 15169628
62.
Journal: Cancer Res. 2004 Jun 1;64(11):3885-91.
Title: Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1.
Author: Benzeno, Sharon|Narla, Goutham|Allina, Jorge|Cheng, George Z|Reeves, Helen L|Banck, Michaela S|Odin, Joseph A|Diehl, J Alan|Germain, Doris|Friedman, Scott L
PMID: 15172998
63.
Journal: Int J Oncol. 2004 Jul;25(1):87-95.
Title: Correlation of Skp2 with carcinogenesis, invasion, metastasis, and prognosis in colorectal tumors.
Author: Li, Jia-Qing|Wu, Fei|Masaki, Tsutomu|Kubo, Akihito|Fujita, Jiro|Dixon, Dan A|Beauchamp, R Daniel|Ishida, Toshihiko|Kuriyama, Shigeki|Imaida, Katsumi
PMID: 15201993
64.
Journal: Int J Oncol. 2004 Jul;25(1):231-6.
Title: Synthetic bile acid derivatives inhibit cell proliferation and induce apoptosis in HT-29 human colon cancer cells.
Author: Park, Sang Eun|Choi, Hye Joung|Yee, Su Bog|Chung, Hae Young|Suh, Hongsuk|Choi, Yung Hyun|Yoo, Young Hyun|Kim, Nam Deuk
PMID: 15202011
65.
Journal: Int J Hyperthermia. 2004 Jun;20(4):405-19.
Title: Thermal enhancement of oxaliplatin-induced inhibition of cell proliferation and cell cycle progression in human carcinoma cell lines.
Author: Atallah, D|Marsaud, V|Radanyi, C|Kornprobst, M|Rouzier, R|Elias, D|Renoir, J-M
PMID: 15204521
66.
Journal: J Biol Chem. 2004 Sep 17;279(38):40237-44. Epub 2004 Jul 22.
Title: Autocrine and exogenous transforming growth factor beta control cell cycle inhibition through pathways with different sensitivity.
Author: Wang, Jing|Sergina, Natalia|Ko, Tien C|Gong, Jiangeng|Brattain, Michael G
PMID: 15271980
67.
Journal: Am J Physiol Cell Physiol. 2004 Dec;287(6):C1541-6. Epub 2004 Aug 18.
Title: Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1).
Author: Goke, R|Barth, P|Schmidt, A|Samans, B|Lankat-Buttgereit, B
PMID: 15317660
68.
Journal: Cancer Res. 2004 Sep 1;64(17):6296-303.
Title: P21Cip1 is a critical mediator of the cytotoxic action of thymidylate synthase inhibitors in colorectal carcinoma cells.
Author: Geller, James I|Szekely-Szucs, Kinga|Petak, Istvan|Doyle, Belinda|Houghton, Janet A
PMID: 15342418
69.
Journal: Cancer Res. 2004 Dec 15;64(24):9086-92.
Title: Tetrandrine induces early G1 arrest in human colon carcinoma cells by down-regulating the activity and inducing the degradation of G1-S-specific cyclin-dependent kinases and by inducing p53 and p21Cip1.
Author: Meng, Ling-Hua|Zhang, Hongliang|Hayward, Larry|Takemura, Haruyuki|Shao, Rong-Guang|Pommier, Yves
PMID: 15604277
70.
Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004 Jun;29(3):261-5.
Title: [Effects of celecoxib on the proliferation and apoptosis of human colorectal cancer cell line HT-29].
Author: Peng, Jie|Zhang, Gui-Ying|Xiao, Zhi-Qiang
PMID: 16136956
71.
Journal: Cell Signal. 2005 Jul;17(7):809-16. Epub 2004 Nov 24.
Title: Ciglitazone-induced cellular anti-proliferation increases p27kip1 protein levels through both increased transcriptional activity and inhibition of proteasome degradation.
Author: Chen, Fei|Harrison, Lawrence E
PMID: 15763423
72.
Journal: World J Gastroenterol. 2005 Mar 21;11(11):1693-6.
Title: Effect of indomethacin on cell cycle proteins in colon cancer cell lines.
Author: Xu, Mei-Hua|Zhang, Gui-Ying
PMID: 15786552
73.
Journal: Oncogene. 2005 Jun 9;24(25):4017-25.
Title: Kruppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damage.
Author: Yoon, Hong S|Ghaleb, Amr M|Nandan, Mandayam O|Hisamuddin, Irfan M|Dalton, William Brian|Yang, Vincent W
PMID: 15806166
74.
Journal: Oncogene. 2005 May 19;24(22):3657-68.
Title: Modulation of CDK2-AP1 (p12(DOC-1)) expression in human colorectal cancer.
Author: Yuan, Ziquan|Gaba, Anu G|Kent, Tara Sotsky|Bennett, Anna|Miller, Agnes|Weber, Thomas K
PMID: 15806176
75.
Journal: J Cell Physiol. 2005 Oct;205(1):107-13.
Title: Inhibition of colon cancer cell proliferation by the dietary compound conjugated linoleic acid is mediated by the CDK inhibitor p21CIP1/WAF1.
Author: Lim, Do Y|Tyner, Angela L|Park, Jae-Bong|Lee, Jae-Yong|Choi, Yung H|Park, Jung H Y
PMID: 15880444
76.
Journal: Food Chem Toxicol. 2005 Oct;43(10):1483-95.
Title: Molecular mechanisms of econazole-induced toxicity on human colon cancer cells: G0/G1 cell cycle arrest and caspase 8-independent apoptotic signaling pathways.
Author: Ho, Yuan-Soon|Wu, Chih-Hsiung|Chou, Hsiao-Min|Wang, Ying-Jan|Tseng, How|Chen, Chien-Ho|Chen, Li-Ching|Lee, Chia-Hwa|Lin, Shyr-Yi
PMID: 15919146
77.
Journal: Int J Oncol. 2005 Jul;27(1):69-76.
Title: Effects of p21cip1/waf1 overexpression on growth, apoptosis and differentiation in human colon carcinoma cells.
Author: Izawa, Hikaru|Yamamoto, Hirofumi|Damdinsuren, Bazarragchaa|Ikeda, Kimimasa|Tsujie, Masaki|Suzuki, Rei|Kitani, Kotaro|Seki, Yosuke|Hayashi, Taro|Takemasa, Ichiro|Ikeda, Masataka|Ohue, Masayuki|Sekimoto, Mitsugu|Monden, Takushi|Monden, Morito
PMID: 15942645
78.
Journal: Oncogene. 2005 Dec 1;24(54):7955-63.
Title: Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation.
Author: Gross, Isabelle|Lhermitte, Benoit|Domon-Dell, Claire|Duluc, Isabelle|Martin, Elisabeth|Gaiddon, Christian|Kedinger, Michele|Freund, Jean-Noel
PMID: 16027724
79.
Journal: Cell Cycle. 2005 Sep;4(9):1201-15.
Title: Molecular targets and anticancer potential of indole-3-carbinol and its derivatives.
Author: Aggarwal, Bharat B|Ichikawa, Haruyo
PMID: 16082211
80.
Journal: Cancer Biol Ther. 2005 Nov;4(11):1211-5. Epub 2005 Nov 8.
Title: Aberrant splicing of cables gene, a CDK regulator, in human cancers.
Author: Zhang, Hui|Duan, Hai Ou|Kirley, Sandra D|Zukerberg, Lawrence R|Wu, Chin-Lee
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Journal: Biochem Biophys Res Commun. 2005 Dec 2;337(4):1176-84. Epub 2005 Oct 6.
Title: Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry.
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Journal: FEBS Lett. 2005 Dec 5;579(29):6604-10.
Title: Escherichia coli verotoxin 1 mediates apoptosis in human HCT116 colon cancer cells by inducing overexpression of the GADD family of genes and S phase arrest.
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Journal: World J Gastroenterol. 2005 Dec 7;11(45):7211-7.
Title: Correlation between the expressions of gastrin, somatostatin and cyclin and cyclin-depend kinase in colorectal cancer.
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Journal: Oncogene. 2006 May 25;25(22):3123-38.
Title: Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators.
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Journal: J Nutr. 2006 Apr;136(4):893-8.
Title: Trans-10,cis-12, not cis-9,trans-11, conjugated linoleic acid inhibits G1-S progression in HT-29 human colon cancer cells.
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Journal: Glycobiology. 2006 Jul;16(7):573-83. Epub 2006 Mar 30.
Title: Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway.
Author: Choi, Hee-Jung|Chung, Tae-Wook|Kang, Sung-Koo|Lee, Young-Choon|Ko, Jeong-Heon|Kim, Jong-Guk|Kim, Cheorl-Ho
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Journal: Cancer Res. 2006 Apr 15;66(8):4299-308.
Title: Discovery and evaluation of dual CDK1 and CDK2 inhibitors.
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Journal: Planta Med. 2006 Aug;72(10):917-23.
Title: Inhibition of colon cancer (HT-29) cell proliferation by a triterpenoid isolated from Azadirachta indica is accompanied by cell cycle arrest and up-regulation of p21.
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Journal: J Med Chem. 2006 Nov 2;49(22):6549-60.
Title: Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity.
Author: Chu, Xin-Jie|DePinto, Wanda|Bartkovitz, David|So, Sung-Sau|Vu, Binh T|Packman, Kathryn|Lukacs, Christine|Ding, Qingjie|Jiang, Nan|Wang, Ka|Goelzer, Petra|Yin, Xuefeng|Smith, Melissa A|Higgins, Brian X|Chen, Yingsi|Xiang, Qing|Moliterni, John|Kaplan, Geral
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Journal: Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G66-75.
Title: Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin.
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Journal: Food Chem Toxicol. 2007 Jun;45(6):935-44.
Title: Induction of apoptosis and cell-cycle arrest in human colon cancer cells by meclizine.
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Journal: FEBS Lett. 2007 Mar 6;581(5):865-71.
Title: Surfactin from Bacillus subtilis displays anti-proliferative effect via apoptosis induction, cell cycle arrest and survival signaling suppression.
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Journal: Biochem Pharmacol. 2007 Jun 1;73(11):1715-26. Epub 2007 Feb 4.
Title: Inhibition of G1/S transition potentiates oxaliplatin-induced cell death in colon cancer cell lines.
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Journal: Oncogene. 2007 Oct 18;26(48):6954-8. Epub 2007 May 7.
Title: p21(Waf1/Cip1/Sdi1) mediates retinoblastoma protein degradation.
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Title: A del T poly T (8) mutation in the 3' untranslated region (UTR) of the CDK2-AP1 gene is functionally significant causing decreased mRNA stability resulting in decreased CDK2-AP1 expression in human microsatellite unstable (MSI) colorectal cancer (CRC).
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Journal: Cancer Res. 2007 Sep 1;67(17):8325-34.
Title: Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases.
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Journal: Menopause. 2008 May-Jun;15(3):442-53.
Title: Medroxyprogesterone acetate inhibits proliferation of colon cancer cell lines by modulating cell cycle-related protein expression.
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Journal: Cell Death Differ. 2008 May;15(5):908-19.
Title: p27 Kip1 nuclear localization and cyclin-dependent kinase inhibitory activity are regulated by glycogen synthase kinase-3 in human colon cancer cells.
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Journal: Carcinogenesis. 2008 Jun;29(6):1258-66.
Title: Mesalazine negatively regulates CDC25A protein expression and promotes accumulation of colon cancer cells in S phase.
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Journal: Chem Biol Interact. 2008 Aug 11;174(3):201-10.
Title: Inhibition of cell-cycle progression in human colorectal carcinoma Lovo cells by andrographolide.
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Journal: Naunyn Schmiedebergs Arch Pharmacol. 2008 Dec;378(6):599-608.
Title: Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress.
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Journal: Tumour Biol. 2008;29(5):287-303.
Title: c-myc antisense oligonucleotides sensitize human colorectal cancer cells to chemotherapeutic drugs.
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Journal: BMC Gastroenterol. 2009 May 29;9:39.
Title: Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cells.
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Journal: Biochem Pharmacol. 2009 Jan 15;77(2):151-8.
Title: Indirect participation of Hsp90 in the regulation of the cyclin E turnover.
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Journal: Mol Cancer Ther. 2009 Feb;8(2):324-32.
Title: Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines.
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Journal: Anticancer Res. 2009 Jan;29(1):395-401.
Title: Curcumin synergizes the growth inhibitory properties of Indian toad (Bufo melanostictus Schneider) skin-derived factor (BM-ANF1) in HCT-116 colon cancer cells.
Author: Giri, Biplab|Gomes, Antony|Sengupta, Radha|Banerjee, Sanjeev|Nautiyal, Jyoti|Sarkar, Fazlul H|Majumdar, Adhip P N
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Journal: BMC Gastroenterol. 2009 May 29;9:39.
Title: Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cells.
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Journal: J Cell Physiol. 2009 Nov;221(2):350-8.
Title: E2F4 expression is required for cell cycle progression of normal intestinal crypt cells and colorectal cancer cells.
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Journal: Cancer Res. 2009 Aug 1;69(15):6100-6.
Title: Tumor repressive functions of estrogen receptor beta in SW480 colon cancer cells.
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Journal: Cancer Prev Res (Phila). 2009 Sep;2(9):800-6.
Title: Chemoprevention of mouse intestinal tumorigenesis by the cyclin-dependent kinase inhibitor SNS-032.
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Journal: Int J Oncol. 2009 Nov;35(5):1037-43.
Title: Synergistic effects of lovastatin and celecoxib on caveolin-1 and its down-stream signaling molecules: Implications for colon cancer prevention.
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Journal: J Pharmacol Sci. 2009 Nov;111(3):276-84.
Title: Xanthorrhizol, a natural sesquiterpenoid, induces apoptosis and growth arrest in HCT116 human colon cancer cells.
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Journal: Mol Carcinog. 2010 Mar;49(3):235-46.
Title: The synergistic anticancer effect of troglitazone combined with aspirin causes cell cycle arrest and apoptosis in human lung cancer cells.
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Journal: Mol Cancer Ther. 2010 Apr;9(4):813-24.
Title: Inhibition of aldose reductase prevents growth factor-induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in human colon cancer cells.
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Title: 5,5-Diphenyl-2-thiohydantoin-N10 (DPTH-N10) suppresses proliferation of cultured colon cancer cell line COLO-205 by inhibiting DNA synthesis and activating apoptosis.
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Journal: Eur J Cancer. 2010 Jun;46(9):1752-61.
Title: Functional characterisation of cell cycle-related kinase (CCRK) in colorectal cancer carcinogenesis.
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Journal: Cancer Lett. 2010 Nov 1;297(1):9-17.
Title: Gankyrin promotes the proliferation of human pancreatic cancer.
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Journal: J Cell Biochem. 2010 Jun 1;110(3):687-96.
Title: Targeted disruption of Nemo-like kinase inhibits tumor cell growth by simultaneous suppression of cyclin D1 and CDK2 in human hepatocellular carcinoma.
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Journal: Chem Biol Interact. 2010 Oct 6;188(1):75-85.
Title: Suppression of NF-kappaB and GSK-3beta is involved in colon cancer cell growth inhibition by the PPAR agonist troglitazone.
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Title: A glycoprotein from Laminaria japonica induces apoptosis in HT-29 colon cancer cells.
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Journal: BMC Cancer. 2010 Jul 15;10:370.
Title: Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells.
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Journal: PLoS One. 2010 Oct 1;5(10). pii: e13054.
Title: cDNA microarray gene expression profiling of hedgehog signaling pathway inhibition in human colon cancer cells.
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Title: Effects of DCA on Cell Cycle Proteins in Colonocytes.
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Journal: Med Oncol. 2011 Dec;28(4):1495-506.
Title: Down-regulation of phospho-non-receptor Src tyrosine kinases contributes to growth inhibition of cervical cancer cells.
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Journal: Mol Imaging Biol. 2011 Dec;13(6):1290-300.
Title: Impact of cell-proliferation-associated gene expression on 2-deoxy-2-[(18)f]fluoro-D-glucose (FDG) kinetics as measured by dynamic positron emission tomography (dPET) in colorectal tumors.
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Title: Suppression of colonic polyposis by homeoprotein CDX2 through its nontranscriptional function that stabilizes p27Kip1.
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Journal: Carcinogenesis. 2011 Apr;32(4):629-35.
Title: 6,7,4'-trihydroxyisoflavone inhibits HCT-116 human colon cancer cell proliferation by targeting CDK1 and CDK2.
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Title: Cytotoxic and antineoplastic activity of timosaponin A-III for human colon cancer cells.
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Journal: Carcinogenesis. 2011 Jul;32(7):1033-42.
Title: MicroRNA-342 inhibits colorectal cancer cell proliferation and invasion by directly targeting DNA methyltransferase 1.
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Title: Antitumor effects of a novel benzonaphthofurandione derivative (8e) on the human colon cancer cells in vitro and in vivo through cell cycle arrest accompanied with the modulation of EGFR and mTOR signaling.
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Title: Thermostable direct hemolysin downregulates human colon carcinoma cell proliferation with the involvement of E-cadherin, and beta-catenin/Tcf-4 signaling.
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Journal: Bioorg Med Chem. 2011 Nov 15;19(22):6949-65.
Title: Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors.
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Journal: Exp Ther Med. 2011 Mar;2(2):301-307.
Title: Valproate inhibits colon cancer growth through cell cycle modification in vivo and in vitro.
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Journal: Mol Carcinog. 2012 Nov;51(11):869-80.
Title: A high-fat diet increases angiogenesis, solid tumor growth, and lung metastasis of CT26 colon cancer cells in obesity-resistant BALB/c mice.
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Title: The p53-p21WAF1 checkpoint pathway plays a protective role in preventing DNA rereplication induced by abrogation of FOXF1 function.
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Title: Specific activity of cyclin-dependent kinase I is a new potential predictor of tumour recurrence in stage II colon cancer.
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Title: Gene expression profiles of tumor regression grade in locally advanced rectal cancer after neoadjuvant chemoradiotherapy.
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Title: Chloroquine enhances the chemotherapeutic activity of 5-fluorouracil in a colon cancer cell line via cell cycle alteration.
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Title: Effects of activin and TGFbeta on p21 in colon cancer.
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Journal: Asian Pac J Cancer Prev. 2012;13(8):3757-61.
Title: Crocetin induces cytotoxicity in colon cancer cells via p53-independent mechanisms.
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Title: Cladosporol a stimulates G1-phase arrest of the cell cycle by up-regulation of p21(waf1/cip1) expression in human colon carcinoma HT-29 cells.
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Title: Design, synthesis and inhibitory activities of naringenin derivatives on human colon cancer cells.
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Journal: Food Chem Toxicol. 2013 May;55:424-33.
Title: Suppression of Src/ERK and GSK-3/beta-catenin signaling by pinosylvin inhibits the growth of human colorectal cancer cells.
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Journal: Mol Cancer Res. 2013 Jul;11(7):689-98.
Title: Interactions between SAP155 and FUSE-binding protein-interacting repressor bridges c-Myc and P27Kip1 expression.
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Title: APRIL depletion induces cell cycle arrest and apoptosis through blocking TGF-beta1/ERK signaling pathway in human colorectal cancer cells.
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Journal: Toxicology. 2013 Oct 4;312:36-47.
Title: Wogonin induced G1 cell cycle arrest by regulating Wnt/beta-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells.
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Title: Activation of P27kip1-cyclin D1/E-CDK2 pathway by polysaccharide from Phellinus linteus leads to S-phase arrest in HT-29 cells.
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Title: Plant-derived mAbs have effective anti-cancer activities by increasing ganglioside expression in colon cancers.
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Journal: J Nat Prod. 2013 Dec 27;76(12):2195-202.
Title: Hinokitiol inhibits cell growth through induction of S-phase arrest and apoptosis in human colon cancer cells and suppresses tumor growth in a mouse xenograft experiment.
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Title: Chemopreventive effects of an HDAC2-selective inhibitor on rat colon carcinogenesis and APCmin/+ mouse intestinal tumorigenesis.
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Title: Curcumin suppresses proliferation of colon cancer cells by targeting CDK2.
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Title: Resveratrol inhibits proliferation in human colorectal carcinoma cells by inducing G1/Sphase cell cycle arrest and apoptosis through caspase/cyclinCDK pathways.
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Title: Fucoxanthin induces growth arrest and apoptosis in human bladder cancer T24 cells by up-regulation of p21 and down-regulation of mortalin.
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Journal: Zhonghua Zhong Liu Za Zhi. 2014 Jul;36(7):496-500.
Title: [Effects of small interfering RNA silencing MACC-1 expression on cell proliferation, cell cycle and invasion ability of cervical cancer SiHa cells].
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Title: Celecoxib prevents colitis associated colon carcinogenesis: an upregulation of apoptosis.
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Title: miR-31 promotes proliferation of colon cancer cells by targeting E2F2.
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Title: Downregulation of telomerase activity by diclofenac and curcumin is associated with cell cycle arrest and induction of apoptosis in colon cancer.
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Title: Cell cycle regulation and apoptotic cell death in experimental colon carcinogenesis: intervening with cyclooxygenase-2 inhibitors.
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Title: Ethanol extract of Innotus obliquus (Chaga mushroom) induces G1 cell cycle arrest in HT-29 human colon cancer cells.
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Journal: Oncol Rep. 2015 Sep;34(3):1178-84.
Title: Widdrol, a sesquiterpene isolated from Juniperus chinensis, inhibits angiogenesis by targeting vascular endothelial growth factor receptor 2 signaling.
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Title: Characterization of a Pyrazolo[4,3-d]pyrimidine Inhibitor of Cyclin-Dependent Kinases 2 and 5 and Aurora A With Pro-Apoptotic and Anti-Angiogenic Activity In Vitro.
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Title: Adapalene inhibits the activity of cyclin-dependent kinase 2 in colorectal carcinoma.
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Title: Jianpi Huayu Decoction Inhibits Proliferation in Human Colorectal Cancer Cells (SW480) by Inducing G0/G1-Phase Cell Cycle Arrest and Apoptosis.
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Title: Hesperidin inhibits HeLa cell proliferation through apoptosis mediated by endoplasmic reticulum stress pathways and cell cycle arrest.
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Title: A-kinase anchor protein 4 (AKAP4) a promising therapeutic target of colorectal cancer.
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Title: Crude extract of Rheum palmatum L. Induces cell cycle arrest S phase and apoptosis through mitochondrial-dependent pathways in U-2 OS human osteosarcoma cells.
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Title: Cyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway.
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Title: FAM172A is a tumor suppressor in colorectal carcinoma.
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Journal: Cancer Med. 2016 Feb;5(2):370-85.
Title: Mus81 knockdown improves chemosensitivity of hepatocellular carcinoma cells by inducing S-phase arrest and promoting apoptosis through CHK1 pathway.
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Journal: Int J Oncol. 2016 Mar;48(3):1297-304.
Title: Phosphorylated retinoblastoma protein is a potential predictive marker of irinotecan efficacy for colorectal cancer.
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Title: Decreasing CNPY2 Expression Diminishes Colorectal Tumor Growth and Development through Activation of p53 Pathway.
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Journal: PLoS One. 2016 Feb 9;11(2):e0148775.
Title: Flavokawain C Inhibits Cell Cycle and Promotes Apoptosis, Associated with Endoplasmic Reticulum Stress and Regulation of MAPKs and Akt Signaling Pathways in HCT 116 Human Colon Carcinoma Cells.
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Journal: Cell Biol Int. 2016 May;40(5):560-8.
Title: The AhR is involved in the regulation of LoVo cell proliferation through cell cycle-associated proteins.
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Title: Covalent Modification of CDK2 by 4-Hydroxynonenal as a Mechanism of Inhibition of Cell Cycle Progression.
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Title: Deoxyelephantopin from Elephantopus scaber Inhibits HCT116 Human Colorectal Carcinoma Cell Growth through Apoptosis and Cell Cycle Arrest.
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Journal: Oncol Res. 2016;23(5):237-48.
Title: Raltitrexed Inhibits HepG2 Cell Proliferation via G0/G1 Cell Cycle Arrest.
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Title: IGF2 knockdown in two colorectal cancer cell lines decreases survival, adhesion and modulates survival-associated genes.
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Title: Protocatechualdehyde Induces S-Phase Arrest and Apoptosis by Stimulating the p27(KIP1)-Cyclin A/D1-CDK2 and Mitochondrial Apoptotic Pathways in HT-29 Cells.
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Journal: Oncol Res. 2016;24(3):171-9.
Title: Downregulation of CREB Promotes Cell Proliferation by Mediating G1/S Phase Transition in Hodgkin Lymphoma.
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Journal: Biochim Biophys Acta. 2016 Oct;1862(10):1926-37.
Title: Novel miR-5582-5p functions as a tumor suppressor by inducing apoptosis and cell cycle arrest in cancer cells through direct targeting of GAB1, SHC1, and CDK2.
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Title: Combined PI3K and CDK2 inhibition induces cell death and enhances in vivo antitumour activity in colorectal cancer.
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Journal: Sci Rep. 2016 Sep 15;6:33532.
Title: BG-4, a novel anticancer peptide from bitter gourd (Momordica charantia), promotes apoptosis in human colon cancer cells.
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Title: Serine/arginine-rich splicing factor 7 regulates p21-dependent growth arrest in colon cancer cells.
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Journal: BMC Complement Altern Med. 2016 Oct 1;16(1):384.
Title: Methylferulate from Tamarix aucheriana inhibits growth and enhances chemosensitivity of human colorectal cancer cells: possible mechanism of action.
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Journal: Oncotarget. 2016 Nov 29;7(48):79017-79031.
Title: ING4 suppresses tumor angiogenesis and functions as a prognostic marker in human colorectal cancer.
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Title: MicroRNA-195 suppresses colorectal cancer cells proliferation via targeting FGF2 and regulating Wnt/beta-catenin pathway.
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Journal: Sci Rep. 2016 Dec 6;6:38128.
Title: New arylated benzo[h]quinolines induce anti-cancer activity by oxidative stress-mediated DNA damage.
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Journal: Mol Carcinog. 2017 Jan;56(1):18-35.
Title: Lebein, a snake venom disintegrin, suppresses human colon cancer cells proliferation and tumor-induced angiogenesis through cell cycle arrest, apoptosis induction and inhibition of VEGF expression.
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Journal: Oncogene. 2017 May 4;36(18):2491-2502.
Title: A CDK2 activity signature predicts outcome in CDK2-low cancers.
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Journal: Biomed Pharmacother. 2017 Jan;85:733-739.
Title: NOX2-ROS-HIF-1alpha signaling is critical for the inhibitory effect of oleanolic acid on rectal cancer cell proliferation.
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Journal: Mol Carcinog. 2017 Apr;56(4):1361-1371.
Title: The role of metastasis-associated in colon cancer 1 (MACC1) in endometrial carcinoma tumorigenesis and progression.
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Journal: Food Funct. 2017 Mar 22;8(3):1052-1060.
Title: Identification of terpenoids from Rubus corchorifolius L. f. leaves and their anti-proliferative effects on human cancer cells.
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Title: Novel ent-Kaurane Diterpenoid from Rubus corchorifolius L. f. Inhibits Human Colon Cancer Cell Growth via Inducing Cell Cycle Arrest and Apoptosis.
Author: Chen, Xuexiang|Wu, Xian|Ouyang, Wen|Gu, Min|Gao, Zili|Song, Mingyue|Chen, Yunjiao|Lin, Yanyin|Cao, Yong|Xiao, Hang
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Journal: Nanotechnology. 2017 Mar 7;28(13):135103.
Title: Preparation of carotenoid extracts and nanoemulsions from Lycium barbarum L. and their effects on growth of HT-29 colon cancer cells.
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Journal: Clin Res Hepatol Gastroenterol. 2017 Oct;41(5):592-601.
Title: Mus81 knockdown sensitizes colon cancer cells to chemotherapeutic drugs by activating CHK1 pathway.
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Title: TGFbeta engages MEK/ERK to differentially regulate benign and malignant pancreas cell function.
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Journal: Exp Biol Med (Maywood). 2017 May;242(10):1034-1043.
Title: The soy-derived peptide Vglycin inhibits the growth of colon cancer cells in vitro and in vivo.
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Journal: Mar Drugs. 2017 May 30;15(6). pii: md15060154.
Title: Induction of p53-Independent Apoptosis and G1 Cell Cycle Arrest by Fucoidan in HCT116 Human Colorectal Carcinoma Cells.
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Journal: PLoS One. 2017 Jul 14;12(7):e0181183.
Title: Ursodeoxycholic acid inhibits the proliferation of colon cancer cells by regulating oxidative stress and cancer stem-like cell growth.
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Journal: Mar Drugs. 2017 Jul 20;15(7). pii: md15070221.
Title: Mertensene, a Halogenated Monoterpene, Induces G2/M Cell Cycle Arrest and Caspase Dependent Apoptosis of Human Colon Adenocarcinoma HT29 Cell Line through the Modulation of ERK-1/-2, AKT and NF-kappaB Signaling.
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Journal: Oncol Lett. 2017 Aug;14(2):2223-2231.
Title: p53 performs an essential role in mediating the oncogenic stimulus triggered by loss of expression of neurofibromatosis type 2 during in vitro tumor progression.
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Journal: Sci Rep. 2017 Aug 8;7(1):7599.
Title: Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites.
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Journal: Anticancer Drugs. 2017 Sep;28(8):831-840.
Title: Synergistic antitumor effect of 3-bromopyruvate and 5-fluorouracil against human colorectal cancer through cell cycle arrest and induction of apoptosis.
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Journal: Bioorg Med Chem Lett. 2017 Sep 15;27(18):4399-4404.
Title: Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors.
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Journal: Int J Oncol. 2017 Dec;51(6):1661-1673.
Title: Salicylic acid metabolites and derivatives inhibit CDK activity: Novel insights into aspirin's chemopreventive effects against colorectal cancer.
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Journal: Oncotarget. 2017 Aug 24;8(47):83207-83224.
Title: Inhibition of cell cycle progression by the hydroxytyrosol-cetuximab combination yields enhanced chemotherapeutic efficacy in colon cancer cells.
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Journal: BMC Complement Altern Med. 2017 Dec 13;17(1):531.
Title: Antitumor effect of Quercetin on Y79 retinoblastoma cells via activation of JNK and p38 MAPK pathways.
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Title: Cyclin-dependent kinase 2 inhibitor SU9516 increases sensitivity of colorectal carcinoma cells Caco-2 but not HT29 to BH3 mimetic ABT-737.
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Title: Curcumol induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3beta/cyclin D1 pathway.
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Journal: Biomol Ther (Seoul). 2018 May 1;26(3):313-321.
Title: Cellular Prion Protein Enhances Drug Resistance of Colorectal Cancer Cells via Regulation of a Survival Signal Pathway.
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Title: Simvastatin induces G1 arrest by up-regulating GSK3beta and down-regulating CDK4/cyclin D1 and CDK2/cyclin E1 in human primary colorectal cancer cells.
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Title: Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor.
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Journal: Cell Biol Int. 2018 May;42(5):589-597.
Title: NPTX1 inhibits colon cancer cell proliferation through down-regulating cyclin A2 and CDK2 expression.
Author: Peng, Xiaofeng|Pan, Kangming|Zhao, Wenli|Zhang, Jianzhu|Yuan, Shicheng|Wen, Xiang|Zhou, Wenquan|Yu, Zhijin
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Journal: Pharmacol Ther. 2018 Jun;186:138-151.
Title: CCRK is a novel signalling hub exploitable in cancer immunotherapy.
Author: Mok, Myth T|Zhou, Jingying|Tang, Wenshu|Zeng, Xuezhen|Oliver, Antony W|Ward, Simon E|Cheng, Alfred S
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Journal: Oncol Res. 2018 Aug 23;26(7):1113-1121.
Title: miR-522-3p Promotes Tumorigenesis in Human Colorectal Cancer via Targeting Bloom Syndrome Protein.
Author: Shuai, Feng|Wang, Bo|Dong, Shuxiao
PMID: 29386092
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Journal: Mol Cell Biochem. 2018 Sep;446(1-2):137-148.
Title: P16 promotes the growth and mobility potential of breast cancer both in vitro and in vivo: the key role of the activation of IL-6/JAK2/STAT3 signaling.
Author: Wang, Le|Zhan, Xiangwen|Shen, Xiaomeng|Li, Mingzhe|Yang, Jianming|Yu, Wenhua|Chen, Hao|Jin, Bo|Mao, Zebin
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Journal: Oncotarget. 2017 Dec 28;9(4):5216-5232.
Title: Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy.
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Journal: Mol Cancer Ther. 2018 Jun;17(6):1156-1166.
Title: ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment.
Author: Patel, Hetal|Periyasamy, Manikandan|Sava, Georgina P|Bondke, Alexander|Slafer, Brian W|Kroll, Sebastian H B|Barbazanges, Marion|Starkey, Richard|Ottaviani, Silvia|Harrod, Alison|Aboagye, Eric O|Buluwela, Laki|Fuchter, Matthew J|Barrett, Anthony G M|Coombe
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Journal: Evid Based Complement Alternat Med. 2018 Feb 12;2018:6517034.
Title: A Network Pharmacology Approach to Uncover the Multiple Mechanisms of Hedyotis diffusa Willd. on Colorectal Cancer.
Author: Liu, Xinkui|Wu, Jiarui|Zhang, Dan|Wang, Kaihuan|Duan, Xiaojiao|Zhang, Xiaomeng
PMID: 29619072
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Journal: Food Funct. 2018 Apr 25;9(4):2145-2157.
Title: The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. Part 1: the suppression of cell proliferation, promotion of apoptosis and arrest of the cell cycle.
Author: Afrin, Sadia|Giampieri, Francesca|Gasparrini, Massimiliano|Forbes-Hernandez, Tamara Y|Cianciosi, Danila|Reboredo-Rodriguez, Patricia|Amici, Adolfo|Quiles, Jose L|Battino, Maurizio
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Journal: Bioorg Med Chem Lett. 2018 Jul 1;28(12):2117-2123.
Title: 1,2,3,4,6-Penta-O-galloyl-beta-d-glucose suppresses colon cancer through induction of tumor suppressor.
Author: Kawk, Sang Hee|Kang, Ye Rim|Kim, Yoon Hee
PMID: 29778287
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Journal: Dig Dis Sci. 2018 Sep;63(9):2320-2331.
Title: Down-Regulated LncRNA-HOTAIR Suppressed Colorectal Cancer Cell Proliferation, Invasion, and Migration by Mediating p21.
Author: Lin, Kai|Jiang, Hong|Zhang, Ling-Ling|Jiang, Yi|Yang, Yu-Xian|Qiu, Guo-Dong|She, Yu-Qi|Zheng, Jie-Ting|Chen, Chen|Fang, Ling|Zhang, Shu-Yao
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Journal: Oncol Lett. 2018 Jul;16(1):769-774.
Title: IL-33 notably inhibits the growth of colon cancer cells.
Author: Chen, Xuhui|Lu, Kuanchang|Timko, Noah J|Weir, Dylan M|Zhu, Ziwen|Qin, Chenglu|Mann, Jeffery D|Bai, Qian|Xiao, Huaping|Nicholl, Michael B|Wakefield, Mark R|Fang, Yujiang
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Journal: Cancer Manag Res. 2018 Aug 16;10:2757-2765.
Title: High Spy1 expression predicts poor prognosis in colorectal cancer.
Author: Jin, Qin|Liu, Gang|Bao, Luri|Ma, Yuzhen|Qi, Huidong|Yun, Zhizhong|Dai, Yanfeng|Zhang, Shu
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Journal: Oncol Lett. 2018 Oct;16(4):4640-4648.
Title: Total ginsenosides of Chinese ginseng induces cell cycle arrest and apoptosis in colorectal carcinoma HT-29 cells.
Author: Li, Ting|Sun, Wan|Dong, Xiaoqiao|Yu, Wenhua|Cai, Jianyong|Yuan, Qiang|Shan, Letian|Efferth, Thomas
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Journal: Oncol Lett. 2018 Oct;16(4):4671-4678.
Title: Chaetominine induces cell cycle arrest in human leukemia K562 and colon cancer SW1116 cells.
Author: Yao, Jingyun|Xiao, Jianbo|Wei, Xing|Lu, Yanhua
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Journal: Cell Commun Signal. 2018 Oct 4;16(1):65.
Title: Rhomboid domain-containing protein 1 promotes breast cancer progression by regulating the p-Akt and CDK2 levels.
Author: Zhang, Xin|Zhao, Yuechao|Wang, Changjun|Ju, Hongge|Liu, Wenjie|Zhang, Xiaohui|Miao, Shiying|Wang, Linfang|Sun, Qiang|Song, Wei
PMID: 30286765