Primary Site >> Colorectal Cancer
Gene >> CDK2
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism. PMID: 7591958 Ref: Concurrent amplification of cyclin E and CDK2 genes in colorectal carcinomas. PMID: 7601562 Ref: Coexpression of cdk2/cdc2 and retinoblastoma gene products in colorectal cancer. PMID: 7779716 |
Ref: [RB gene expression in gastrointestinal tract]. PMID: 8920658 Ref: Suppression of cancer cell growth by adenovirus expressing p21(WAF1/CIP1) deficient in PCNA interaction. PMID: 9816291 |
Ref: Disruption of fibronectin binding to the alpha 5 beta 1 integrin stimulates the expression of cyclin-dependent kinases and DNA synthesis through activation of extracellular signal-regulated kinase. PMID: 9430710 Ref: Mutated p21(WAF1/CIP1/SDI1) lacking CDK-inhibitory activity fails to prevent apoptosis in human colorectal carcinoma cells. PMID: 9488034 Ref: Cdk2/cdc2 expression in colon carcinogenesis and effects of cdk2/cdc2 inhibitor in colon cancer cells. PMID: 9664116 Ref: Caco-2 intestinal cell differentiation is associated with G1 arrest and suppression of CDK2 and CDK4. PMID: 9814966 |
Ref: Comparative effects of overexpression of p27Kip1 and p21Cip1/Waf1 on growth and differentiation in human colon carcinoma cells. PMID: 9926925 Ref: Absence of the cell cycle inhibitor p27Kip1 protein predicts poor outcome in patients with stage I-III colorectal cancer. PMID: 10030411 Ref: Amplified CDK2 and cdc2 activities in primary colorectal carcinoma. PMID: 10091728 Ref: Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. PMID: 10201372 Ref: Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a). PMID: 10207115 Ref: Differential cyclin-dependent kinase expression and activation in human colon cancer. PMID: 10216486 Ref: NA22598, a novel antitumor compound, reduces cyclin D1 levels, arrests cell cycle at G1 phase, and inhibits anchorage-independent growth of human tumor cells. PMID: 10366423 Ref: G1-checkpoint function including a cyclin-dependent kinase 2 regulatory pathway as potential determinant of 7-hydroxystaurosporine (UCN-01)-induced apoptosis and G1-phase accumulation. PMID: 10665655 |
Ref: Cell cycle molecular targets in novel anticancer drug discovery. PMID: 10788588 Ref: Changes in E2F binding after phenylbutyrate-induced differentiation of Caco-2 colon cancer cells. PMID: 10914745 Ref: Downregulation of cyclin D1 alters cdk 4- and cdk 2-specific phosphorylation of retinoblastoma protein. PMID: 11032757 Ref: Expression of pRB, cyclin/cyclin-dependent kinases and E2F1/DP-1 in human tumor lines in cell culture and in xenograft tissues and response to cell cycle agents. PMID: 11052627 Ref: A vitamin D3 analog induces a G1-phase arrest in CaCo-2 cells by inhibiting cdk2 and cdk6: roles of cyclin E, p21Waf1, and p27Kip1. PMID: 11089522 Ref: Mechanism of cell cycle arrest caused by histone deacetylase inhibitors in human carcinoma cells. PMID: 11132966 Ref: Inhibition of X-ray and doxorubicin-induced apoptosis by butyrolactone I, a CDK-specific inhibitor, in human tumor cells. PMID: 11329882 |
Ref: Synergistic effects of dexamethasone and genistein on the expression of Cdk inhibitor p21WAF1/CIP1 in human hepatocellular and colorectal carcinoma cells. PMID: 11295047 Ref: Upregulated expression of angiogenesis genes and down regulation of cell cycle genes in human colorectal cancer tissue determined by cDNA macroarray. PMID: 11299727 Ref: Curcumin induced modulation of cell cycle and apoptosis in gastric and colon cancer cells. PMID: 11396178 Ref: Polyamine depletion arrests growth of IEC-6 and Caco-2 cells by different mechanisms. PMID: 11408253 Ref: HMG-CoA reductase inhibitor mevastatin enhances the growth inhibitory effect of butyrate in the colorectal carcinoma cell line Caco-2. PMID: 11408350 Ref: Downregulation of the cyclin D1/Cdk4 complex occurs during resveratrol-induced cell cycle arrest in colon cancer cell lines. PMID: 11481417 Ref: Tributyrin, an oral butyrate analogue, induces apoptosis through the activation of caspase-3. PMID: 11485828 Ref: DNA alkylation-induced phosphorylation of p53 and activation of kinases in colon cancer cells. PMID: 11494044 Ref: A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cells. PMID: 11507069 Ref: Inactivation of p21 by E1A leads to the induction of apoptosis in DNA-damaged cells. PMID: 11559818 Ref: Cell cycle regulation in the G1 phase: a promising target for the development of new chemotherapeutic anticancer agents. PMID: 11562278 Ref: Expression of cyclin E and cyclin-dependent kinase 2 correlates with metastasis and prognosis in colorectal carcinoma. PMID: 11567224 Ref: The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax. PMID: 11574543 Ref: Activation of cyclin E-dependent kinase activity in colorectal cancer. PMID: 11680595 Ref: Induction of cyclin E and inhibition of DNA synthesis by the novel acronycine derivative S23906-1 precede the irreversible arrest of tumor cells in S phase leading to apoptosis. PMID: 11723246 |
Ref: Transforming growth factor beta 1 induces proliferation in colon carcinoma cells by Ras-dependent, smad-independent down-regulation of p21cip1. PMID: 11784716 Ref: Resveratrol, a chemopreventive agent, disrupts the cell cycle control of human SW480 colorectal tumor cells. PMID: 12119558 Ref: Butyrate and aspirin in combination have an enhanced effect on apoptosis in human colorectal cancer cells. PMID: 12131661 Ref: Monoterpenes inhibit proliferation of human colon cancer cells by modulating cell cycle-related protein expression. PMID: 12175534 Ref: p107 Expression in colorectal tumours rises during carcinogenesis and falls during invasion. PMID: 12204665 Ref: SU9516, a cyclin-dependent kinase 2 inhibitor, promotes accumulation of high molecular weight E2F complexes in human colon carcinoma cells. PMID: 12234612 Ref: Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells. PMID: 12376477 Ref: Hygrolidin induces p21 expression and abrogates cell cycle progression at G1 and S phases. PMID: 12379237 Ref: Cyclin A correlates with carcinogenesis and metastasis, and p27(kip1) correlates with lymphatic invasion, in colorectal neoplasms. PMID: 12395374 Ref: Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 2. Probing the indeno ring substituent pattern. PMID: 12431050 Ref: In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine). PMID: 12432547 Ref: E7070: a novel synthetic sulfonamide targeting the cell cycle progression for the treatment of cancer. PMID: 12439332 |
Ref: Proliferation of cancer cells despite CDK2 inhibition. PMID: 12676582 Ref: Transforming growth factor beta 1 increases the stability of p21/WAF1/CIP1 protein and inhibits CDK2 kinase activity in human colon carcinoma FET cells. PMID: 12810668 Ref: [Stat3 signal transduction pathway orchestrates G1 to S cell cycle transition in colon cancer cells]. PMID: 12920809 Ref: p21-dependent inhibition of colon cancer cell growth by mevastatin is independent of inhibition of G1 cyclin-dependent kinases. PMID: 12930830 Ref: Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells. PMID: 14614451 Ref: Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. PMID: 14625550 Ref: Cell cycle dysregulation induced by cytoplasm of Lactococcus lactis ssp lactis in SNUC2A, a colon cancer cell line. PMID: 14690796 |
Ref: Establishment of a colonic adenoma cell line (GEKI-2): spectral karyotype analysis and functional characterization. PMID: 14648095 Ref: The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway. PMID: 14729633 Ref: Abrogation of Chk1-mediated S/G2 checkpoint by UCN-01 enhances ara-C-induced cytotoxicity in human colon cancer cells. PMID: 15169628 Ref: Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1. PMID: 15172998 Ref: Correlation of Skp2 with carcinogenesis, invasion, metastasis, and prognosis in colorectal tumors. PMID: 15201993 Ref: Synthetic bile acid derivatives inhibit cell proliferation and induce apoptosis in HT-29 human colon cancer cells. PMID: 15202011 Ref: Thermal enhancement of oxaliplatin-induced inhibition of cell proliferation and cell cycle progression in human carcinoma cell lines. PMID: 15204521 Ref: Autocrine and exogenous transforming growth factor beta control cell cycle inhibition through pathways with different sensitivity. PMID: 15271980 Ref: Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1). PMID: 15317660 Ref: P21Cip1 is a critical mediator of the cytotoxic action of thymidylate synthase inhibitors in colorectal carcinoma cells. PMID: 15342418 Ref: Tetrandrine induces early G1 arrest in human colon carcinoma cells by down-regulating the activity and inducing the degradation of G1-S-specific cyclin-dependent kinases and by inducing p53 and p21Cip1. PMID: 15604277 Ref: [Effects of celecoxib on the proliferation and apoptosis of human colorectal cancer cell line HT-29]. PMID: 16136956 |
Ref: Ciglitazone-induced cellular anti-proliferation increases p27kip1 protein levels through both increased transcriptional activity and inhibition of proteasome degradation. PMID: 15763423 Ref: Effect of indomethacin on cell cycle proteins in colon cancer cell lines. PMID: 15786552 Ref: Kruppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damage. PMID: 15806166 Ref: Modulation of CDK2-AP1 (p12(DOC-1)) expression in human colorectal cancer. PMID: 15806176 Ref: Inhibition of colon cancer cell proliferation by the dietary compound conjugated linoleic acid is mediated by the CDK inhibitor p21CIP1/WAF1. PMID: 15880444 Ref: Molecular mechanisms of econazole-induced toxicity on human colon cancer cells: G0/G1 cell cycle arrest and caspase 8-independent apoptotic signaling pathways. PMID: 15919146 Ref: Effects of p21cip1/waf1 overexpression on growth, apoptosis and differentiation in human colon carcinoma cells. PMID: 15942645 Ref: Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation. PMID: 16027724 Ref: Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. PMID: 16082211 Ref: Aberrant splicing of cables gene, a CDK regulator, in human cancers. PMID: 16177568 Ref: Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry. PMID: 16226712 Ref: Escherichia coli verotoxin 1 mediates apoptosis in human HCT116 colon cancer cells by inducing overexpression of the GADD family of genes and S phase arrest. PMID: 16297916 Ref: Correlation between the expressions of gastrin, somatostatin and cyclin and cyclin-depend kinase in colorectal cancer. PMID: 16437675 |
Ref: Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators. PMID: 16434969 Ref: Trans-10,cis-12, not cis-9,trans-11, conjugated linoleic acid inhibits G1-S progression in HT-29 human colon cancer cells. PMID: 16549447 Ref: Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway. PMID: 16574813 Ref: Discovery and evaluation of dual CDK1 and CDK2 inhibitors. PMID: 16618755 Ref: Inhibition of colon cancer (HT-29) cell proliferation by a triterpenoid isolated from Azadirachta indica is accompanied by cell cycle arrest and up-regulation of p21. PMID: 16858664 Ref: Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity. PMID: 17064073 |
Ref: Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin. PMID: 16901994 Ref: Induction of apoptosis and cell-cycle arrest in human colon cancer cells by meclizine. PMID: 17222494 Ref: Surfactin from Bacillus subtilis displays anti-proliferative effect via apoptosis induction, cell cycle arrest and survival signaling suppression. PMID: 17292358 Ref: Inhibition of G1/S transition potentiates oxaliplatin-induced cell death in colon cancer cell lines. PMID: 17343830 Ref: p21(Waf1/Cip1/Sdi1) mediates retinoblastoma protein degradation. PMID: 17486059 Ref: A del T poly T (8) mutation in the 3' untranslated region (UTR) of the CDK2-AP1 gene is functionally significant causing decreased mRNA stability resulting in decreased CDK2-AP1 expression in human microsatellite unstable (MSI) colorectal cancer (CRC). PMID: 17689689 Ref: Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases. PMID: 17804748 |
Ref: Medroxyprogesterone acetate inhibits proliferation of colon cancer cell lines by modulating cell cycle-related protein expression. PMID: 18202593 Ref: p27 Kip1 nuclear localization and cyclin-dependent kinase inhibitory activity are regulated by glycogen synthase kinase-3 in human colon cancer cells. PMID: 18408738 Ref: Mesalazine negatively regulates CDC25A protein expression and promotes accumulation of colon cancer cells in S phase. PMID: 18495657 Ref: Inhibition of cell-cycle progression in human colorectal carcinoma Lovo cells by andrographolide. PMID: 18619950 Ref: Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress. PMID: 18663430 Ref: c-myc antisense oligonucleotides sensitize human colorectal cancer cells to chemotherapeutic drugs. PMID: 18802399 |
Ref: Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cells. PMID: 2670081 Ref: Indirect participation of Hsp90 in the regulation of the cyclin E turnover. PMID: 18977205 Ref: Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines. PMID: 19174555 Ref: Curcumin synergizes the growth inhibitory properties of Indian toad (Bufo melanostictus Schneider) skin-derived factor (BM-ANF1) in HCT-116 colon cancer cells. PMID: 19331178 Ref: Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3'-diindolylmethane in HT-29 human colon cancer cells. PMID: 19480695 Ref: E2F4 expression is required for cell cycle progression of normal intestinal crypt cells and colorectal cancer cells. PMID: 19562678 Ref: Tumor repressive functions of estrogen receptor beta in SW480 colon cancer cells. PMID: 19602591 Ref: Chemoprevention of mouse intestinal tumorigenesis by the cyclin-dependent kinase inhibitor SNS-032. PMID: 19723896 Ref: Synergistic effects of lovastatin and celecoxib on caveolin-1 and its down-stream signaling molecules: Implications for colon cancer prevention. PMID: 19787257 Ref: Xanthorrhizol, a natural sesquiterpenoid, induces apoptosis and growth arrest in HCT116 human colon cancer cells. PMID: 19926935 |
Ref: The synergistic anticancer effect of troglitazone combined with aspirin causes cell cycle arrest and apoptosis in human lung cancer cells. PMID: 19908241 Ref: Inhibition of aldose reductase prevents growth factor-induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in human colon cancer cells. PMID: 20354121 Ref: 5,5-Diphenyl-2-thiohydantoin-N10 (DPTH-N10) suppresses proliferation of cultured colon cancer cell line COLO-205 by inhibiting DNA synthesis and activating apoptosis. PMID: 20449574 Ref: Functional characterisation of cell cycle-related kinase (CCRK) in colorectal cancer carcinogenesis. PMID: 20466538 Ref: Gankyrin promotes the proliferation of human pancreatic cancer. PMID: 20483533 Ref: Targeted disruption of Nemo-like kinase inhibits tumor cell growth by simultaneous suppression of cyclin D1 and CDK2 in human hepatocellular carcinoma. PMID: 20512928 Ref: Suppression of NF-kappaB and GSK-3beta is involved in colon cancer cell growth inhibition by the PPAR agonist troglitazone. PMID: 20540935 Ref: A glycoprotein from Laminaria japonica induces apoptosis in HT-29 colon cancer cells. PMID: 20615460 Ref: Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells. PMID: 20630104 Ref: cDNA microarray gene expression profiling of hedgehog signaling pathway inhibition in human colon cancer cells. PMID: 20957031 Ref: Effects of DCA on Cell Cycle Proteins in Colonocytes. PMID: 21152226 |
Ref: Down-regulation of phospho-non-receptor Src tyrosine kinases contributes to growth inhibition of cervical cancer cells. PMID: 20532678 Ref: Impact of cell-proliferation-associated gene expression on 2-deoxy-2-[(18)f]fluoro-D-glucose (FDG) kinetics as measured by dynamic positron emission tomography (dPET) in colorectal tumors. PMID: 21153447 Ref: Suppression of colonic polyposis by homeoprotein CDX2 through its nontranscriptional function that stabilizes p27Kip1. PMID: 21224344 Ref: 6,7,4'-trihydroxyisoflavone inhibits HCT-116 human colon cancer cell proliferation by targeting CDK1 and CDK2. PMID: 21258042 Ref: Cytotoxic and antineoplastic activity of timosaponin A-III for human colon cancer cells. PMID: 21370894 Ref: MicroRNA-342 inhibits colorectal cancer cell proliferation and invasion by directly targeting DNA methyltransferase 1. PMID: 21565830 Ref: Antitumor effects of a novel benzonaphthofurandione derivative (8e) on the human colon cancer cells in vitro and in vivo through cell cycle arrest accompanied with the modulation of EGFR and mTOR signaling. PMID: 21600193 Ref: Thermostable direct hemolysin downregulates human colon carcinoma cell proliferation with the involvement of E-cadherin, and beta-catenin/Tcf-4 signaling. PMID: 21625458 Ref: Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors. PMID: 21982796 Ref: Valproate inhibits colon cancer growth through cell cycle modification in vivo and in vitro. PMID: 22977502 |
Ref: A high-fat diet increases angiogenesis, solid tumor growth, and lung metastasis of CT26 colon cancer cells in obesity-resistant BALB/c mice. PMID: 21919080 Ref: The p53-p21WAF1 checkpoint pathway plays a protective role in preventing DNA rereplication induced by abrogation of FOXF1 function. PMID: 21964066 Ref: Specific activity of cyclin-dependent kinase I is a new potential predictor of tumour recurrence in stage II colon cancer. PMID: 22108518 Ref: Gene expression profiles of tumor regression grade in locally advanced rectal cancer after neoadjuvant chemoradiotherapy. PMID: 22711167 Ref: Chloroquine enhances the chemotherapeutic activity of 5-fluorouracil in a colon cancer cell line via cell cycle alteration. PMID: 22716215 Ref: Effects of activin and TGFbeta on p21 in colon cancer. PMID: 22761777 Ref: Crocetin induces cytotoxicity in colon cancer cells via p53-independent mechanisms. PMID: 23098467 |
Ref: Cladosporol a stimulates G1-phase arrest of the cell cycle by up-regulation of p21(waf1/cip1) expression in human colon carcinoma HT-29 cells. PMID: 22025467 Ref: Design, synthesis and inhibitory activities of naringenin derivatives on human colon cancer cells. PMID: 23177257 Ref: Suppression of Src/ERK and GSK-3/beta-catenin signaling by pinosylvin inhibits the growth of human colorectal cancer cells. PMID: 23333577 Ref: Interactions between SAP155 and FUSE-binding protein-interacting repressor bridges c-Myc and P27Kip1 expression. PMID: 23594796 Ref: [Effect of cell cycle-related novel gene CACUL1 on the apoptosis of colorectal cancer cells in vitro]. PMID: 23643261 Ref: APRIL depletion induces cell cycle arrest and apoptosis through blocking TGF-beta1/ERK signaling pathway in human colorectal cancer cells. PMID: 23867993 Ref: Wogonin induced G1 cell cycle arrest by regulating Wnt/beta-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells. PMID: 23907061 Ref: Activation of P27kip1-cyclin D1/E-CDK2 pathway by polysaccharide from Phellinus linteus leads to S-phase arrest in HT-29 cells. PMID: 24060681 Ref: Plant-derived mAbs have effective anti-cancer activities by increasing ganglioside expression in colon cancers. PMID: 24078119 Ref: Hinokitiol inhibits cell growth through induction of S-phase arrest and apoptosis in human colon cancer cells and suppresses tumor growth in a mouse xenograft experiment. PMID: 24308647 Ref: Kaempferol Induces Cell Cycle Arrest in HT-29 Human Colon Cancer Cells. PMID: 25337553 |
Ref: Chemopreventive effects of an HDAC2-selective inhibitor on rat colon carcinogenesis and APCmin/+ mouse intestinal tumorigenesis. PMID: 24218540 Ref: Cyclin-dependent kinases regulate apoptosis of intestinal epithelial cells. PMID: 24242917 Ref: CCNG2 expression is downregulated in colorectal carcinoma and its clinical significance. PMID: 24307622 Ref: Curcumin suppresses proliferation of colon cancer cells by targeting CDK2. PMID: 24550143 Ref: A functional role for Smad7 in sustaining colon cancer cell growth and survival. PMID: 24556688 Ref: Resveratrol inhibits proliferation in human colorectal carcinoma cells by inducing G1/Sphase cell cycle arrest and apoptosis through caspase/cyclinCDK pathways. PMID: 25050564 Ref: Fucoxanthin induces growth arrest and apoptosis in human bladder cancer T24 cells by up-regulation of p21 and down-regulation of mortalin. PMID: 25187415 Ref: [Effects of small interfering RNA silencing MACC-1 expression on cell proliferation, cell cycle and invasion ability of cervical cancer SiHa cells]. PMID: 25327653 Ref: Celecoxib prevents colitis associated colon carcinogenesis: an upregulation of apoptosis. PMID: 25443739 |
Ref: miR-31 promotes proliferation of colon cancer cells by targeting E2F2. PMID: 25362258 Ref: Downregulation of telomerase activity by diclofenac and curcumin is associated with cell cycle arrest and induction of apoptosis in colon cancer. PMID: 25744732 Ref: Cell cycle regulation and apoptotic cell death in experimental colon carcinogenesis: intervening with cyclooxygenase-2 inhibitors. PMID: 25825916 Ref: Ethanol extract of Innotus obliquus (Chaga mushroom) induces G1 cell cycle arrest in HT-29 human colon cancer cells. PMID: 25861415 Ref: Widdrol, a sesquiterpene isolated from Juniperus chinensis, inhibits angiogenesis by targeting vascular endothelial growth factor receptor 2 signaling. PMID: 26133679 Ref: Characterization of a Pyrazolo[4,3-d]pyrimidine Inhibitor of Cyclin-Dependent Kinases 2 and 5 and Aurora A With Pro-Apoptotic and Anti-Angiogenic Activity In Vitro. PMID: 26198005 Ref: Adapalene inhibits the activity of cyclin-dependent kinase 2 in colorectal carcinoma. PMID: 26398439 Ref: Jianpi Huayu Decoction Inhibits Proliferation in Human Colorectal Cancer Cells (SW480) by Inducing G0/G1-Phase Cell Cycle Arrest and Apoptosis. PMID: 26457107 Ref: Hesperidin inhibits HeLa cell proliferation through apoptosis mediated by endoplasmic reticulum stress pathways and cell cycle arrest. PMID: 26459308 Ref: A-kinase anchor protein 4 (AKAP4) a promising therapeutic target of colorectal cancer. PMID: 26590805 |
Ref: Crude extract of Rheum palmatum L. Induces cell cycle arrest S phase and apoptosis through mitochondrial-dependent pathways in U-2 OS human osteosarcoma cells. PMID: 25689151 Ref: Cyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway. PMID: 26028036 Ref: FAM172A is a tumor suppressor in colorectal carcinoma. PMID: 26637224 Ref: Mus81 knockdown improves chemosensitivity of hepatocellular carcinoma cells by inducing S-phase arrest and promoting apoptosis through CHK1 pathway. PMID: 26714930 Ref: Phosphorylated retinoblastoma protein is a potential predictive marker of irinotecan efficacy for colorectal cancer. PMID: 26783196 Ref: Decreasing CNPY2 Expression Diminishes Colorectal Tumor Growth and Development through Activation of p53 Pathway. PMID: 26835537 Ref: Flavokawain C Inhibits Cell Cycle and Promotes Apoptosis, Associated with Endoplasmic Reticulum Stress and Regulation of MAPKs and Akt Signaling Pathways in HCT 116 Human Colon Carcinoma Cells. PMID: 26859847 Ref: The AhR is involved in the regulation of LoVo cell proliferation through cell cycle-associated proteins. PMID: 26861731 Ref: Covalent Modification of CDK2 by 4-Hydroxynonenal as a Mechanism of Inhibition of Cell Cycle Progression. PMID: 26910110 Ref: Deoxyelephantopin from Elephantopus scaber Inhibits HCT116 Human Colorectal Carcinoma Cell Growth through Apoptosis and Cell Cycle Arrest. PMID: 27007366 Ref: Raltitrexed Inhibits HepG2 Cell Proliferation via G0/G1 Cell Cycle Arrest. PMID: 27098147 Ref: IGF2 knockdown in two colorectal cancer cell lines decreases survival, adhesion and modulates survival-associated genes. PMID: 27337954 Ref: Protocatechualdehyde Induces S-Phase Arrest and Apoptosis by Stimulating the p27(KIP1)-Cyclin A/D1-CDK2 and Mitochondrial Apoptotic Pathways in HT-29 Cells. PMID: 27447597 Ref: Downregulation of CREB Promotes Cell Proliferation by Mediating G1/S Phase Transition in Hodgkin Lymphoma. PMID: 27458098 Ref: Novel miR-5582-5p functions as a tumor suppressor by inducing apoptosis and cell cycle arrest in cancer cells through direct targeting of GAB1, SHC1, and CDK2. PMID: 27475256 Ref: Combined PI3K and CDK2 inhibition induces cell death and enhances in vivo antitumour activity in colorectal cancer. PMID: 27529512 Ref: BG-4, a novel anticancer peptide from bitter gourd (Momordica charantia), promotes apoptosis in human colon cancer cells. PMID: 27628414 Ref: Serine/arginine-rich splicing factor 7 regulates p21-dependent growth arrest in colon cancer cells. PMID: 27644562 Ref: Methylferulate from Tamarix aucheriana inhibits growth and enhances chemosensitivity of human colorectal cancer cells: possible mechanism of action. PMID: 27716288 Ref: ING4 suppresses tumor angiogenesis and functions as a prognostic marker in human colorectal cancer. PMID: 27806345 Ref: MicroRNA-195 suppresses colorectal cancer cells proliferation via targeting FGF2 and regulating Wnt/beta-catenin pathway. PMID: 27904776 Ref: New arylated benzo[h]quinolines induce anti-cancer activity by oxidative stress-mediated DNA damage. PMID: 27922047 |
Ref: Lebein, a snake venom disintegrin, suppresses human colon cancer cells proliferation and tumor-induced angiogenesis through cell cycle arrest, apoptosis induction and inhibition of VEGF expression. PMID: 26824338 Ref: A CDK2 activity signature predicts outcome in CDK2-low cancers. PMID: 27819669 Ref: NOX2-ROS-HIF-1alpha signaling is critical for the inhibitory effect of oleanolic acid on rectal cancer cell proliferation. PMID: 27938946 Ref: The role of metastasis-associated in colon cancer 1 (MACC1) in endometrial carcinoma tumorigenesis and progression. PMID: 27991682 Ref: Identification of terpenoids from Rubus corchorifolius L. f. leaves and their anti-proliferative effects on human cancer cells. PMID: 28134947 Ref: Novel ent-Kaurane Diterpenoid from Rubus corchorifolius L. f. Inhibits Human Colon Cancer Cell Growth via Inducing Cell Cycle Arrest and Apoptosis. PMID: 28169543 Ref: Preparation of carotenoid extracts and nanoemulsions from Lycium barbarum L. and their effects on growth of HT-29 colon cancer cells. PMID: 28266352 Ref: Mus81 knockdown sensitizes colon cancer cells to chemotherapeutic drugs by activating CHK1 pathway. PMID: 28291626 Ref: TGFbeta engages MEK/ERK to differentially regulate benign and malignant pancreas cell function. PMID: 28368414 Ref: The soy-derived peptide Vglycin inhibits the growth of colon cancer cells in vitro and in vivo. PMID: 28492347 Ref: Induction of p53-Independent Apoptosis and G1 Cell Cycle Arrest by Fucoidan in HCT116 Human Colorectal Carcinoma Cells. PMID: 28555064 Ref: Ursodeoxycholic acid inhibits the proliferation of colon cancer cells by regulating oxidative stress and cancer stem-like cell growth. PMID: 28708871 Ref: Mertensene, a Halogenated Monoterpene, Induces G2/M Cell Cycle Arrest and Caspase Dependent Apoptosis of Human Colon Adenocarcinoma HT29 Cell Line through the Modulation of ERK-1/-2, AKT and NF-kappaB Signaling. PMID: 28726723 Ref: p53 performs an essential role in mediating the oncogenic stimulus triggered by loss of expression of neurofibromatosis type 2 during in vitro tumor progression. PMID: 28789444 Ref: Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites. PMID: 28790461 Ref: Synergistic antitumor effect of 3-bromopyruvate and 5-fluorouracil against human colorectal cancer through cell cycle arrest and induction of apoptosis. PMID: 28816773 Ref: Synthesis and biological evaluation of N9-cis-cyclobutylpurine derivatives for use as cyclin-dependent kinase (CDK) inhibitors. PMID: 28827110 Ref: Salicylic acid metabolites and derivatives inhibit CDK activity: Novel insights into aspirin's chemopreventive effects against colorectal cancer. PMID: 29075787 Ref: Inhibition of cell cycle progression by the hydroxytyrosol-cetuximab combination yields enhanced chemotherapeutic efficacy in colon cancer cells. PMID: 29137335 Ref: Antitumor effect of Quercetin on Y79 retinoblastoma cells via activation of JNK and p38 MAPK pathways. PMID: 29237430 Ref: Cyclin-dependent kinase 2 inhibitor SU9516 increases sensitivity of colorectal carcinoma cells Caco-2 but not HT29 to BH3 mimetic ABT-737. PMID: 29372687 |
Ref: Curcumol induces cell cycle arrest in colon cancer cells via reactive oxygen species and Akt/ GSK3beta/cyclin D1 pathway. PMID: 28684297 Ref: Cellular Prion Protein Enhances Drug Resistance of Colorectal Cancer Cells via Regulation of a Survival Signal Pathway. PMID: 28822989 Ref: Simvastatin induces G1 arrest by up-regulating GSK3beta and down-regulating CDK4/cyclin D1 and CDK2/cyclin E1 in human primary colorectal cancer cells. PMID: 28833099 Ref: Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor. PMID: 29063678 Ref: NPTX1 inhibits colon cancer cell proliferation through down-regulating cyclin A2 and CDK2 expression. PMID: 29345391 Ref: CCRK is a novel signalling hub exploitable in cancer immunotherapy. PMID: 29360538 Ref: miR-522-3p Promotes Tumorigenesis in Human Colorectal Cancer via Targeting Bloom Syndrome Protein. PMID: 29386092 Ref: P16 promotes the growth and mobility potential of breast cancer both in vitro and in vivo: the key role of the activation of IL-6/JAK2/STAT3 signaling. PMID: 29388151 Ref: Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy. PMID: 29435174 Ref: ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment. PMID: 29545334 Ref: A Network Pharmacology Approach to Uncover the Multiple Mechanisms of Hedyotis diffusa Willd. on Colorectal Cancer. PMID: 29619072 Ref: The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. Part 1: the suppression of cell proliferation, promotion of apoptosis and arrest of the cell cycle. PMID: 29645049 Ref: 1,2,3,4,6-Penta-O-galloyl-beta-d-glucose suppresses colon cancer through induction of tumor suppressor. PMID: 29778287 Ref: Down-Regulated LncRNA-HOTAIR Suppressed Colorectal Cancer Cell Proliferation, Invasion, and Migration by Mediating p21. PMID: 29808247 Ref: IL-33 notably inhibits the growth of colon cancer cells. PMID: 29963144 Ref: High Spy1 expression predicts poor prognosis in colorectal cancer. PMID: 30147372 Ref: Total ginsenosides of Chinese ginseng induces cell cycle arrest and apoptosis in colorectal carcinoma HT-29 cells. PMID: 30197678 Ref: Chaetominine induces cell cycle arrest in human leukemia K562 and colon cancer SW1116 cells. PMID: 30214601 Ref: Rhomboid domain-containing protein 1 promotes breast cancer progression by regulating the p-Akt and CDK2 levels. PMID: 30286765 |